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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:Pancreatic Intraepithelial Neoplasia
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Accession:DOID:9004078 term browser browse the term
Definition:A histologically well-defined precursor to invasive ductal adenocarcinoma of the pancreas.
Synonyms:exact_synonym: PanIN
 primary_id: RDO:9000688


show annotations for term's descendants           Sort by:
Pancreatic Intraepithelial Neoplasia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agr2 anterior gradient 2, protein disulphide isomerase family member ISO protein:increased expression:pancreas RGD PMID:19714807 RGD:2325658 NCBI chr 6:52,708,602...52,729,378
Ensembl chr 6:52,708,602...52,729,371 		JBrowse link
G Bmi1 BMI1 proto-oncogene, polycomb ring finger ISO protein:increased expression:pancreatic acinar cell:
protein:increased expression:exocrine pancreas: 		RGD PMID:19585519 PMID:19585519 RGD:9491843, RGD:9491843 NCBI chr17:81,332,175...81,341,625
Ensembl chr17:81,332,214...81,388,690 		JBrowse link
G Cbx7 chromobox 7 disease_progression ISO protein:decreased expression:pancreas RGD PMID:20185297 RGD:9587360 NCBI chr 7:111,460,656...111,479,231
Ensembl chr 7:111,460,656...111,477,973 		JBrowse link
G Ccnd1 cyclin D1 disease_progression ISO protein:increased expression:pancreas (human) RGD PMID:12882690 PMID:11751405 RGD:13462061, RGD:13464129 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Dnmt1 DNA methyltransferase 1 ISO protein:increased expression:pancreas RGD PMID:19424621 RGD:9588974 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659 		JBrowse link
G Hdac1 histone deacetylase 1 ISO protein:increased expression:pancreas RGD PMID:19424621 RGD:9588974 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta severity
disease_progression		 ISO RGD PMID:22406536 PMID:22056382 RGD:13838740, RGD:13838742 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 18969
    disease of anatomical entity 18249
      endocrine system disease 6821
        endocrine gland cancer 2453
          pancreatic cancer 430
            Pancreatic Intraepithelial Neoplasia 7
Path 2
Term Annotations click to browse term
  disease 18969
    disease of cellular proliferation 7691
      cancer 5508
        organ system cancer 5262
          endocrine gland cancer 2453
            pancreatic cancer 430
              Pancreatic Intraepithelial Neoplasia 7
paths to the root