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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:bronchiolitis obliterans
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Accession:DOID:2799 term browser browse the term
Definition:A obstructive lung disease involving obstruction of the bronchioles due to inflammation and fibrosis which occurs as a complication of various lung conditions or physiological insults. (DO)
Synonyms:exact_synonym: Constrictive Bronchiolitides;   Constrictive Bronchiolitis;   Exudative Bronchiolitides;   Exudative Bronchiolitis;   Obliterative Bronchiolitis;   Proliferative Bronchiolitides;   Proliferative Bronchiolitis;   bronchiolitis exudativa;   bronchiolitis fibrosa obliterans
 primary_id: MESH:D001989
 xref: EFO:0007183;   GARD:9551;   NCI:C62580
For additional species annotation, visit the Alliance of Genome Resources.

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bronchiolitis obliterans term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adora2a adenosine A2a receptor ISO RGD PMID:19766783 RGD:4890362 NCBI chrNW_004936619:597,970...618,564
Ensembl chrNW_004936619:608,441...616,779 		JBrowse link
G Ccl17 C-C motif chemokine ligand 17 ISO RGD PMID:18785972 RGD:4145604 NCBI chrNW_004936475:9,475,013...9,476,326
Ensembl chrNW_004936475:9,474,961...9,476,398 		JBrowse link
G Ccl22 C-C motif chemokine ligand 22 ISO RGD PMID:20628341 RGD:4891471 NCBI chrNW_004936475:9,432,505...9,436,240
Ensembl chrNW_004936475:9,432,505...9,436,240 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ISO mRNA:increased expression:lung (rat) RGD PMID:14611812 PMID:19840961 RGD:2307195 RGD:4889978 NCBI chrNW_004936490:253,279...259,947
Ensembl chrNW_004936490:253,034...259,965 		JBrowse link
G Cd86 CD86 molecule ISO RGD PMID:11266944 RGD:2307206 NCBI chrNW_004936536:8,414,491...8,481,712 JBrowse link
G Csf2 colony stimulating factor 2 ISO associated with Respiratory Aspiration;protein:increased expression:serum RGD PMID:18557728 RGD:2317286 NCBI chrNW_004936647:3,081,896...3,083,864
Ensembl chrNW_004936647:3,081,896...3,083,864 		JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 ISO protein:increased expression:respiratory system fluid/secretion RGD PMID:12097412 PMID:16709871 RGD:5135441 RGD:5135451 NCBI chrNW_004936676:60,869...63,028
Ensembl chrNW_004936676:60,621...63,106 		JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 ISO protein:increased expression:respiratory system fluid/secretion RGD PMID:12097412 RGD:5135451 NCBI chrNW_004936676:72,383...73,697
Ensembl chrNW_004936676:71,667...73,738 		JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 ISO protein:increased expression:respiratory system fluid/secretion RGD PMID:12097412 PMID:16709871 RGD:5135441 RGD:5135451 NCBI chrNW_004936676:33,580...40,323
Ensembl chrNW_004936676:32,128...40,329 		JBrowse link
G Cxcr3 C-X-C motif chemokine receptor 3 ISO RGD PMID:12097412 PMID:16709871 RGD:5135441 RGD:5135451 NCBI chrNW_004936762:66,636...69,694
Ensembl chrNW_004936762:66,636...69,373 		JBrowse link
G Edn1 endothelin 1 ISO human gene in a rat model RGD PMID:9595474 RGD:8662402 NCBI chrNW_004936534:885,489...892,292
Ensembl chrNW_004936534:885,287...891,772 		JBrowse link
G Foxp3 forkhead box P3 ISO mRNA:increased expression:lung RGD PMID:19840961 RGD:4889978 NCBI chrNW_004936721:1,118,376...1,125,282
Ensembl chrNW_004936721:1,118,782...1,132,308 		JBrowse link
G Hmox1 heme oxygenase 1 ISO RGD PMID:12973103 RGD:4145412 NCBI chrNW_004936492:5,042,353...5,049,216
Ensembl chrNW_004936492:5,042,330...5,049,311 		JBrowse link
G Ifng interferon gamma ISO CTD Direct Evidence: therapeutic CTD PMID:16137903 NCBI chrNW_004936545:6,139,130...6,144,543
Ensembl chrNW_004936545:6,139,116...6,148,452 		JBrowse link
G Il13 interleukin 13 ISO protein:increased expression:bronchoalveolar lavage fluid RGD PMID:17182591 RGD:4146242 NCBI chrNW_004936647:2,529,933...2,532,503
Ensembl chrNW_004936647:2,530,491...2,532,373 		JBrowse link
G Il13ra1 interleukin 13 receptor subunit alpha 1 ISO RGD PMID:17182591 RGD:4146242 NCBI chrNW_004936479:11,052,077...11,108,915
Ensembl chrNW_004936479:11,050,249...11,108,909 		JBrowse link
G Il13ra2 interleukin 13 receptor subunit alpha 2 ISO RGD PMID:17182591 RGD:4146242 NCBI chrNW_004936499:860,179...883,884
Ensembl chrNW_004936499:863,599...883,855 		JBrowse link
G Il17a interleukin 17A ISO mRNA:increased expression:trachea RGD PMID:20393404 RGD:4143277 NCBI chrNW_004936476:8,621,860...8,625,008
Ensembl chrNW_004936476:8,621,860...8,625,008 		JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO protein:increased expression:lung RGD PMID:11889437 RGD:4143176 NCBI chrNW_004936783:1,447,158...1,466,331
Ensembl chrNW_004936783:1,447,106...1,466,340 		JBrowse link
G Il6 interleukin 6 ISO RGD PMID:20393404 RGD:4143277 NCBI chrNW_004936549:7,015,595...7,016,246 JBrowse link
G LOC101968921 angiotensin-converting enzyme ISO RGD PMID:17097496 RGD:4140933 NCBI chrNW_004936541:4,157,847...4,178,156
Ensembl chrNW_004936541:4,157,393...4,178,177 		JBrowse link
G Mmp9 matrix metallopeptidase 9 ISO protein:increased expression, increased activity:bronchoalveolar lavage fluid RGD PMID:20417130 RGD:5130759 NCBI chrNW_004936514:7,038,240...7,045,873
Ensembl chrNW_004936514:7,037,639...7,045,793 		JBrowse link
G Muc1 mucin 1, cell surface associated ISO protein:increased expression:serum RGD PMID:16969297 RGD:5131273 NCBI chrNW_004936580:4,691,870...4,694,092 JBrowse link
G Nod2 nucleotide binding oligomerization domain containing 2 ISO RGD PMID:18158963 RGD:5131450 NCBI chrNW_004936475:3,708,069...3,742,845
Ensembl chrNW_004936475:3,713,362...3,745,982 		JBrowse link
G Nos2 nitric oxide synthase 2 ISO associated with lung transplantation; protein:increased expression:lung RGD PMID:11112135 RGD:4892082 NCBI chrNW_004936538:4,052,277...4,097,051
Ensembl chrNW_004936538:4,052,448...4,097,051 		JBrowse link
G Nos3 nitric oxide synthase 3 ISO protein:increased expression:lung RGD PMID:15136885 RGD:4892068 NCBI chrNW_004936527:6,427,147...6,445,770
Ensembl chrNW_004936527:6,427,093...6,446,534 		JBrowse link
G Scgb1a1 secretoglobin family 1A member 1 ISO associated with lung transplantation; protein:decreased expression:serum,bronchoalveolar lavage RGD PMID:11981419 RGD:5147386 NCBI chrNW_004936581:798,738...801,614
Ensembl chrNW_004936581:798,739...801,633 		JBrowse link
G Sftpd surfactant protein D ISO RGD PMID:18347569 RGD:4143500 NCBI chrNW_004936716:60,754...73,010
Ensembl chrNW_004936716:60,656...73,099 		JBrowse link
cryptogenic organizing pneumonia term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnfrsf1a TNF receptor superfamily member 1A ISO protein:increased expression:lung, macrophage (human) RGD PMID:21144722 RGD:5131112 NCBI chrNW_004936709:1,407,327...1,421,448
Ensembl chrNW_004936709:1,407,278...1,421,921 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B ISO protein:increased expression:lung, lymphocyte (human) RGD PMID:21144722 RGD:5131112 NCBI chrNW_004936474:908,414...935,765
Ensembl chrNW_004936474:908,485...934,177 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 14500
    disease of anatomical entity 14149
      Skin and Connective Tissue Diseases 6479
        connective tissue disease 5036
          interstitial lung disease 443
            bronchiolitis obliterans 30
              Organizing Pneumonia + 2
Path 2
Term Annotations click to browse term
  disease 14500
    disease of anatomical entity 14149
      respiratory system disease 3171
        lower respiratory tract disease 2032
          lung disease 1995
            obstructive lung disease 426
              bronchitis 77
                bronchiolitis 66
                  bronchiolitis obliterans 30
                    Organizing Pneumonia + 2
paths to the root