Foxp3 (forkhead box P3) - Rat Genome Database

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Gene: Foxp3 (forkhead box P3) Ictidomys tridecemlineatus
Analyze
Symbol: Foxp3
Name: forkhead box P3
RGD ID: 12613499
Description: ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity (inferred); INVOLVED IN alpha-beta T cell proliferation (ortholog); B cell homeostasis (ortholog); CD4-positive, alpha-beta T cell differentiation (ortholog); ASSOCIATED WITH Acute-On-Chronic Liver Failure (ortholog); adult T-cell leukemia/lymphoma (ortholog); Airway Remodeling (ortholog); FOUND IN nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: forkhead box protein P3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X34,877,987 - 34,897,169 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367211,118,782 - 1,132,308 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367211,118,376 - 1,125,282 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute-On-Chronic Liver Failure  (ISO)
adult T-cell leukemia/lymphoma  (ISO)
Airway Remodeling  (ISO)
allergic disease  (ISO)
anemia  (ISO)
Animal Toxoplasmosis  (ISO)
anogenital venereal wart  (ISO)
asthma  (ISO)
autistic disorder  (ISO)
bacterial pneumonia  (ISO)
Breast Neoplasms  (ISO)
bronchiolitis obliterans  (ISO)
cervical squamous cell carcinoma  (ISO)
chlamydia  (ISO)
Chronic Hepatitis B  (ISO)
Chronic Hepatitis C  (ISO)
colorectal cancer  (ISO)
congenital disorder of glycosylation type IIm  (ISO)
cutaneous leishmaniasis  (ISO)
dermatitis  (ISO)
diabetes mellitus  (ISO)
Dysbiosis  (ISO)
endometriosis  (ISO)
Endotoxemia  (ISO)
Epstein-Barr virus infectious disease  (ISO)
Experimental Arthritis  (ISO)
Experimental Autoimmune Myocarditis  (ISO)
Experimental Autoimmune Neuritis  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
genetic disease  (ISO)
graft-versus-host disease  (ISO)
hepatitis B  (ISO)
hepatitis C  (ISO)
hepatocellular carcinoma  (ISO)
Hydranencephaly with Renal Aplasia-Dysplasia  (ISO)
Hydrops Fetalis  (ISO)
hypertension  (ISO)
hypothyroidism  (ISO)
immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome  (ISO)
infectious mononucleosis  (ISO)
intrahepatic cholangiocarcinoma  (ISO)
Korean hemorrhagic fever  (ISO)
Lung Injury  (ISO)
Lung Neoplasms  (ISO)
malaria  (ISO)
multidrug-resistant tuberculosis  (ISO)
Neuralgia  (ISO)
neurodegeneration with brain iron accumulation 5  (ISO)
Neurodevelopmental Disorders  (ISO)
occupational dermatitis  (ISO)
papillomavirus infectious disease  (ISO)
pleural tuberculosis  (ISO)
polycystic ovary syndrome  (ISO)
primary biliary cholangitis  (ISO)
pulmonary tuberculosis  (ISO)
Recurrent Respiratory Papillomatosis  (ISO)
rheumatoid arthritis  (ISO)
Sepsis  (ISO)
spermatogenic failure 3  (ISO)
Spinal Cord Injuries  (ISO)
Squamous Intraepithelial Lesions of the Cervix  (ISO)
syndromic X-linked intellectual disability Lubs type  (ISO)
syphilis  (ISO)
Transplant Rejection  (ISO)
tropical spastic paraparesis  (ISO)
type 1 diabetes mellitus  (ISO)
vaccinia  (ISO)
Wiskott-Aldrich syndrome  (ISO)
Wound Infection  (ISO)
X-linked epilepsy with variable learning disabilities and behavior disorders  (ISO)
X-linked severe congenital neutropenia  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
alpha-beta T cell proliferation  (IEA,ISO)
B cell homeostasis  (IEA,ISO)
CD4-positive, alpha-beta T cell differentiation  (IEA,ISO)
CD4-positive, alpha-beta T cell proliferation  (IEA,ISO)
CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation  (IEA,ISO)
chromatin remodeling  (IEA,ISO)
DNA-templated transcription  (IEA,ISO)
establishment of endothelial blood-brain barrier  (ISO)
gene expression  (IEA,ISO)
immature T cell proliferation in thymus  (IEA,ISO)
inflammatory response  (IEA,ISO)
isotype switching to IgE isotypes  (IEA,ISO)
lymphocyte proliferation  (IEA,ISO)
myeloid cell homeostasis  (IEA,ISO)
negative regulation of alpha-beta T cell proliferation  (IEA,ISO)
negative regulation of CD4-positive, alpha-beta T cell proliferation  (IEA,ISO)
negative regulation of cell population proliferation  (IEA)
negative regulation of chronic inflammatory response  (IEA,ISO)
negative regulation of cytokine production  (IEA)
negative regulation of defense response to virus  (ISO)
negative regulation of DNA-templated transcription  (IEA,ISO)
negative regulation of gene expression  (IEA,ISO)
negative regulation of immune response  (IEA)
negative regulation of inflammatory response  (IEA,ISO)
negative regulation of interleukin-10 production  (IEA,ISO)
negative regulation of interleukin-17 production  (IEA)
negative regulation of interleukin-2 production  (IEA,ISO)
negative regulation of interleukin-4 production  (IEA,ISO)
negative regulation of interleukin-5 production  (IEA,ISO)
negative regulation of interleukin-6 production  (IEA,ISO)
negative regulation of isotype switching to IgE isotypes  (IEA,ISO)
negative regulation of lymphocyte proliferation  (IEA,ISO)
negative regulation of T cell cytokine production  (IEA)
negative regulation of T cell proliferation  (IEA,ISO)
negative regulation of T-helper 17 cell differentiation  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
negative regulation of tumor necrosis factor production  (IEA,ISO)
negative regulation of type II interferon production  (IEA,ISO)
positive regulation of CD4-positive, alpha-beta T cell differentiation  (IEA,ISO)
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation  (IEA,ISO)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of immature T cell proliferation in thymus  (IEA,ISO)
positive regulation of interleukin-4 production  (IEA,ISO)
positive regulation of peripheral T cell tolerance induction  (IEA,ISO)
positive regulation of regulatory T cell differentiation  (IEA,ISO)
positive regulation of T cell anergy  (IEA,ISO)
positive regulation of T cell tolerance induction  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of transforming growth factor beta1 production  (IEA,ISO)
regulation of DNA-templated transcription  (IEA)
regulation of immunoglobulin production  (IEA,ISO)
regulation of isotype switching to IgG isotypes  (IEA,ISO)
regulation of T cell anergy  (IEA)
regulation of transcription by RNA polymerase II  (IEA,ISO)
regulatory T cell differentiation  (IEA,ISO)
response to lipopolysaccharide  (ISO)
response to rapamycin  (ISO)
response to virus  (IEA)
T cell activation  (IEA,ISO)
T cell anergy  (IEA,ISO)
T cell mediated immunity  (IEA,ISO)
T cell proliferation  (IEA,ISO)
T cell receptor signaling pathway  (IEA,ISO)
T cell tolerance induction  (IEA,ISO)
tolerance induction  (IEA,ISO)
tolerance induction to self antigen  (IEA,ISO)
transcription by RNA polymerase II  (IEA,ISO)
transforming growth factor beta1 production  (IEA,ISO)

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA)
nucleoplasm  (IEA)
nucleus  (IEA,ISO)

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Foxp3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X34,877,987 - 34,897,169 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367211,118,782 - 1,132,308 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367211,118,376 - 1,125,282 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FOXP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X49,250,438 - 49,264,710 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX49,250,438 - 49,264,800 (-)EnsemblGRCh38hg38GRCh38
GRCh37X49,106,899 - 49,121,172 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X48,994,354 - 49,008,232 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X48,863,780 - 48,877,659NCBI
CeleraX52,543,105 - 52,557,472 (+)NCBICelera
Cytogenetic MapXp11.23NCBI
HuRefX46,763,332 - 46,777,541 (-)NCBIHuRef
CHM1_1X49,139,199 - 49,153,588 (-)NCBICHM1_1
T2T-CHM13v2.0X48,662,300 - 48,676,549 (-)NCBIT2T-CHM13v2.0
Foxp3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X7,445,915 - 7,461,482 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX7,439,883 - 7,461,484 (+)EnsemblGRCm39 Ensembl
GRCm38X7,579,676 - 7,595,243 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX7,573,644 - 7,595,245 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X7,156,819 - 7,172,360 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X6,736,652 - 6,752,193 (+)NCBIMGSCv36mm8
CeleraX3,876,537 - 3,892,077 (-)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX3.41NCBI
Foxp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X17,580,380 - 17,601,181 (-)NCBIGRCr8
mRatBN7.2X14,908,494 - 14,924,994 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX14,908,494 - 14,923,838 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX19,722,817 - 19,738,131 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X20,345,005 - 20,360,319 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X16,610,149 - 16,625,463 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X15,753,175 - 15,768,648 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,753,175 - 15,768,522 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X16,544,710 - 16,565,562 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X26,950,006 - 26,965,329 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
CeleraX14,991,861 - 15,007,179 (-)NCBICelera
Cytogenetic MapXq12NCBI
Foxp3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955543731,707 - 742,606 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955543731,707 - 742,606 (-)NCBIChiLan1.0ChiLan1.0
FOXP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X50,742,581 - 50,759,396 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X50,745,946 - 50,762,762 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X41,550,462 - 41,567,492 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X49,402,652 - 49,417,029 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX49,402,652 - 49,417,029 (-)Ensemblpanpan1.1panPan2
FOXP3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X42,331,229 - 42,362,841 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX42,344,108 - 42,350,758 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX16,722,772 - 16,729,421 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X42,484,818 - 42,504,672 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX42,482,908 - 42,492,386 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X42,469,693 - 42,476,343 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X42,457,152 - 42,463,801 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X42,552,106 - 42,558,755 (-)NCBIUU_Cfam_GSD_1.0
FOXP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX43,303,785 - 43,322,968 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X43,303,777 - 43,328,164 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X48,151,901 - 48,175,580 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FOXP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X46,349,890 - 46,365,133 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607611,912,136 - 11,927,083 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Foxp3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624893995,182 - 1,008,679 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624893995,145 - 1,008,492 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_021735537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAESOR010000614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSSTOT00000004419   ⟹   ENSSTOP00000003963
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_0049367211,118,782 - 1,132,308 (-)Ensembl
RefSeq Acc Id: XM_021735537   ⟹   XP_021591212
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2X34,877,987 - 34,897,169 (-)NCBI
SpeTri2.0NW_0049367211,118,376 - 1,125,282 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_021591212 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000003963.2
GenBank Protein KAG3272107 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_021591212   ⟸   XM_021735537
- UniProtKB: I3M475 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSTOP00000003963   ⟸   ENSSTOT00000004419
Protein Domains
Fork-head


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000004416 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000004419.3 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.10 UniProtKB/TrEMBL
  1.20.5.340 UniProtKB/TrEMBL
InterPro FH_FOXP3 UniProtKB/TrEMBL
  Fork_head_dom UniProtKB/TrEMBL
  FOXP-CC UniProtKB/TrEMBL
  TF_fork_head_CS_2 UniProtKB/TrEMBL
  WH-like_DNA-bd_sf UniProtKB/TrEMBL
  WH_DNA-bd_sf UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/TrEMBL
NCBI Gene Foxp3 ENTREZGENE
PANTHER FORKHEAD BOX P, ISOFORM C UniProtKB/TrEMBL
  FORKHEAD BOX PROTEIN P3 UniProtKB/TrEMBL
Pfam Forkhead UniProtKB/TrEMBL
  FOXP-CC UniProtKB/TrEMBL
PRINTS FORKHEAD UniProtKB/TrEMBL
PROSITE FORK_HEAD_2 UniProtKB/TrEMBL
  FORK_HEAD_3 UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_1 UniProtKB/TrEMBL
SMART SM00339 UniProtKB/TrEMBL
Superfamily-SCOP SSF46785 UniProtKB/TrEMBL
UniProt I3M475 ENTREZGENE, UniProtKB/TrEMBL