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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:axitinib
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Accession:CHEBI:66910 term browser browse the term
Definition:An indazole substituted at position 3 by a 2-(pyridin-2-yl)vinyl group and at position 6 by a 2-(N-methylaminocarboxy)phenylsulfanyl group. Used for the treatment of advanced renal cell carcinoma after failure of a first line systemic treatment.
Synonyms:exact_synonym: N-methyl-2-({3-[(E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl}sulfanyl)benzamide
 related_synonym: AG-013736;   Formula=C22H18N4OS;   InChI=1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+;   InChIKey=RITAVMQDGBJQJZ-FMIVXFBMSA-N;   Inlyta;   N-methyl-2-({3-[(E)-2-(pyridin-2-yl)vinyl]-1H-indazol-6-yl}sulfanyl)benzamide;   SMILES=CNC(=O)c1ccccc1Sc1ccc2c(\\C=C\\c3ccccn3)n[nH]c2c1;   axitinibum
 xref: CAS:319460-85-0;   Drug_Central:4225;   KEGG:D03218
 xref_mesh: MESH:C503983
 xref: PMID:20740300;   PMID:21301929;   PMID:21670972;   PMID:22168366;   PMID:22170007;   PMID:22248343;   PMID:22504156;   PMID:22545314;   PMID:22549112;   PMID:22644797;   PMID:22683928;   PMID:22699078;   PMID:22706540;   PMID:22733795;   PMID:22787405;   Reaxys:11333336;   Wikipedia:Axitinib


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axitinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
ISO PD 0325901 promotes the reaction [Axitinib results in decreased phosphorylation of MAPK1 protein] CTD PMID:27560553 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
ISO PD 0325901 promotes the reaction [Axitinib results in decreased phosphorylation of MAPK3 protein] CTD PMID:27560553 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO axitinib inhibits the reaction [VEGFA protein results in increased phosphorylation of NOS3 protein] CTD PMID:27044328 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 multiple interactions ISO axitinib inhibits the reaction [VEGFA protein results in increased phosphorylation of PAK1 protein] CTD PMID:27044328 NCBI chr 1:162,768,156...162,883,356
Ensembl chr 1:162,768,156...162,883,355
JBrowse link
G Thbs1 thrombospondin 1 multiple interactions EXP axitinib inhibits the reaction [Cyclophosphamide results in increased expression of THBS1 protein] CTD PMID:18202011 NCBI chr 3:109,862,120...109,873,466
Ensembl chr 3:109,862,117...109,873,466
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO axitinib inhibits the reaction [VEGFA protein results in increased phosphorylation of NOS3 protein]; axitinib inhibits the reaction [VEGFA protein results in increased phosphorylation of PAK1 protein] CTD PMID:27044328 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      application 19391
        pharmaceutical 19272
          drug 19272
            antineoplastic agent 16982
              axitinib 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic acid 18060
                                        carboacyl group 17346
                                          univalent carboacyl group 17346
                                            carbamoyl group 17132
                                              carboxamide 17132
                                                monocarboxylic acid amide 14551
                                                  arenecarboxamide 6507
                                                    benzamides 6507
                                                      axitinib 6
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