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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:axitinib
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Accession:CHEBI:66910 term browser browse the term
Definition:An indazole substituted at position 3 by a 2-(pyridin-2-yl)vinyl group and at position 6 by a 2-(N-methylaminocarboxy)phenylsulfanyl group. Used for the treatment of advanced renal cell carcinoma after failure of a first line systemic treatment.
Synonyms:exact_synonym: N-methyl-2-({3-[(E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl}sulfanyl)benzamide
 related_synonym: AG-013736;   Formula=C22H18N4OS;   InChI=1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+;   InChIKey=RITAVMQDGBJQJZ-FMIVXFBMSA-N;   Inlyta;   N-methyl-2-({3-[(E)-2-(pyridin-2-yl)vinyl]-1H-indazol-6-yl}sulfanyl)benzamide;   SMILES=CNC(=O)c1ccccc1Sc1ccc2c(\\C=C\\c3ccccn3)n[nH]c2c1;   axitinibum
 xref: CAS:319460-85-0;   Drug_Central:4225;   KEGG:D03218
 xref_mesh: MESH:C503983
 xref: PMID:20740300;   PMID:21301929;   PMID:21670972;   PMID:22168366;   PMID:22170007;   PMID:22248343;   PMID:22504156;   PMID:22545314;   PMID:22549112;   PMID:22644797;   PMID:22683928;   PMID:22699078;   PMID:22706540;   PMID:22733795;   PMID:22787405;   Reaxys:11333336;   Wikipedia:Axitinib


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axitinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
decreases activity		 ISO [Axitinib results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Loperamide CTD PMID:31299239 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation		 ISO mirdametinib promotes the reaction [Axitinib results in decreased phosphorylation of MAPK1 protein] CTD PMID:27560553 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation		 ISO mirdametinib promotes the reaction [Axitinib results in decreased phosphorylation of MAPK3 protein] CTD PMID:27560553 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO axitinib inhibits the reaction [VEGFA protein results in increased phosphorylation of NOS3 protein] CTD PMID:27044328 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 multiple interactions ISO axitinib inhibits the reaction [VEGFA protein results in increased phosphorylation of PAK1 protein] CTD PMID:27044328 NCBI chr 1:152,111,172...152,226,390
Ensembl chr 1:152,111,188...152,226,383 		JBrowse link
G Thbs1 thrombospondin 1 multiple interactions EXP axitinib inhibits the reaction [Cyclophosphamide results in increased expression of THBS1 protein] CTD PMID:18202011 NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440 		JBrowse link
G Tp53 tumor protein p53 affects activity ISO Axitinib affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO axitinib inhibits the reaction [VEGFA protein results in increased phosphorylation of NOS3 protein]; axitinib inhibits the reaction [VEGFA protein results in increased phosphorylation of PAK1 protein] CTD PMID:27044328 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
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  CHEBI ontology 19811
    role 19818
      application 19630
        pharmaceutical 19503
          drug 19471
            antineoplastic agent 17769
              axitinib 8
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            heteroorganic entity 19459
                              organochalcogen compound 19222
                                organooxygen compound 19137
                                  carbon oxoacid 18597
                                    carboxylic acid 18594
                                      carboacyl group 17675
                                        univalent carboacyl group 17675
                                          carbamoyl group 17524
                                            carboxamide 17547
                                              monocarboxylic acid amide 15660
                                                arenecarboxamide 8245
                                                  benzamides 8250
                                                    axitinib 8
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