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ONTOLOGY REPORT - ANNOTATIONS


Term:axitinib
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Accession:CHEBI:66910 term browser browse the term
Definition:An indazole substituted at position 3 by a 2-(pyridin-2-yl)vinyl group and at position 6 by a 2-(N-methylaminocarboxy)phenylsulfanyl group. Used for the treatment of advanced renal cell carcinoma after failure of a first line systemic treatment.
Synonyms:exact_synonym: N-methyl-2-({3-[(E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl}sulfanyl)benzamide
 related_synonym: AG-013736;   Formula=C22H18N4OS;   InChI=1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+;   InChIKey=RITAVMQDGBJQJZ-FMIVXFBMSA-N;   Inlyta;   N-methyl-2-({3-[(E)-2-(pyridin-2-yl)vinyl]-1H-indazol-6-yl}sulfanyl)benzamide;   SMILES=CNC(=O)c1ccccc1Sc1ccc2c(\\C=C\\c3ccccn3)n[nH]c2c1;   axitinibum
 xref: CAS:319460-85-0 "ChemIDplus";   CAS:319460-85-0 "KEGG DRUG";   Drug_Central:4225 "DrugCentral";   KEGG:D03218
 xref_mesh: MESH:C503983
 xref: PMID:20740300 "Europe PMC";   PMID:21301929 "Europe PMC";   PMID:21670972 "Europe PMC";   PMID:22168366 "Europe PMC";   PMID:22170007 "Europe PMC";   PMID:22248343 "Europe PMC";   PMID:22504156 "Europe PMC";   PMID:22545314 "Europe PMC";   PMID:22549112 "Europe PMC";   PMID:22644797 "Europe PMC";   PMID:22683928 "Europe PMC";   PMID:22699078 "Europe PMC";   PMID:22706540 "Europe PMC";   PMID:22733795 "Europe PMC";   PMID:22787405 "Europe PMC";   Reaxys:11333336 "Reaxys";   Wikipedia:Axitinib


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axitinib term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nos3 nitric oxide synthase 3 JBrowse link 4 7,321,908 7,342,404 RGD:6480464
G Pak1 p21 (RAC1) activated kinase 1 JBrowse link 1 162,768,156 162,883,356 RGD:6480464
G Thbs1 thrombospondin 1 JBrowse link 3 109,862,120 109,873,466 RGD:6480464
G Vegfa vascular endothelial growth factor A JBrowse link 9 17,340,341 17,355,681 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19669
    role 19613
      application 19235
        pharmaceutical 19097
          drug 19097
            antineoplastic agent 16555
              axitinib 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 19669
    subatomic particle 19665
      composite particle 19665
        hadron 19665
          baryon 19665
            nucleon 19665
              atomic nucleus 19665
                atom 19665
                  main group element atom 19545
                    p-block element atom 19545
                      carbon group element atom 19428
                        carbon atom 19420
                          organic molecular entity 19420
                            organic group 18343
                              organic divalent group 18334
                                organodiyl group 18334
                                  carbonyl group 18222
                                    carbonyl compound 18222
                                      carboxylic acid 17923
                                        carboacyl group 16943
                                          univalent carboacyl group 16943
                                            carbamoyl group 16622
                                              carboxamide 16622
                                                monocarboxylic acid amide 13180
                                                  arenecarboxamide 6406
                                                    benzamides 6406
                                                      axitinib 4
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.