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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:axitinib
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Accession:CHEBI:66910 term browser browse the term
Definition:An indazole substituted at position 3 by a 2-(pyridin-2-yl)vinyl group and at position 6 by a 2-(N-methylaminocarboxy)phenylsulfanyl group. Used for the treatment of advanced renal cell carcinoma after failure of a first line systemic treatment.
Synonyms:exact_synonym: N-methyl-2-({3-[(E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl}sulfanyl)benzamide
 related_synonym: AG-013736;   Formula=C22H18N4OS;   InChI=1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+;   InChIKey=RITAVMQDGBJQJZ-FMIVXFBMSA-N;   Inlyta;   N-methyl-2-({3-[(E)-2-(pyridin-2-yl)vinyl]-1H-indazol-6-yl}sulfanyl)benzamide;   SMILES=CNC(=O)c1ccccc1Sc1ccc2c(\\C=C\\c3ccccn3)n[nH]c2c1;   axitinibum
 xref: CAS:319460-85-0;   Drug_Central:4225;   KEGG:D03218
 xref_mesh: MESH:C503983
 xref: PMID:20740300;   PMID:21301929;   PMID:21670972;   PMID:22168366;   PMID:22170007;   PMID:22248343;   PMID:22504156;   PMID:22545314;   PMID:22549112;   PMID:22644797;   PMID:22683928;   PMID:22699078;   PMID:22706540;   PMID:22733795;   PMID:22787405;   Reaxys:11333336;   Wikipedia:Axitinib


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axitinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
decreases activity
ISO [Axitinib results in decreased activity of CYP3A4 protein] which results in decreased metabolism of Loperamide CTD PMID:31299239 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
ISO PD 0325901 promotes the reaction [Axitinib results in decreased phosphorylation of MAPK1 protein] CTD PMID:27560553 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
ISO PD 0325901 promotes the reaction [Axitinib results in decreased phosphorylation of MAPK3 protein] CTD PMID:27560553 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO axitinib inhibits the reaction [VEGFA protein results in increased phosphorylation of NOS3 protein] CTD PMID:27044328 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Pak1 p21 (RAC1) activated kinase 1 multiple interactions ISO axitinib inhibits the reaction [VEGFA protein results in increased phosphorylation of PAK1 protein] CTD PMID:27044328 NCBI chr 1:152,111,172...152,226,390
Ensembl chr 1:152,111,188...152,226,383
JBrowse link
G Thbs1 thrombospondin 1 multiple interactions EXP axitinib inhibits the reaction [Cyclophosphamide results in increased expression of THBS1 protein] CTD PMID:18202011 NCBI chr 3:105,056,286...105,071,445
Ensembl chr 3:105,056,292...105,071,440
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO axitinib inhibits the reaction [VEGFA protein results in increased phosphorylation of NOS3 protein]; axitinib inhibits the reaction [VEGFA protein results in increased phosphorylation of PAK1 protein] CTD PMID:27044328 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

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  CHEBI ontology 19821
    role 19769
      application 19481
        pharmaceutical 19329
          drug 19329
            antineoplastic agent 17317
              axitinib 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic group 18737
                              organic divalent group 18728
                                organodiyl group 18728
                                  carbonyl group 18675
                                    carbonyl compound 18675
                                      carboxylic acid 18373
                                        carboacyl group 17485
                                          univalent carboacyl group 17485
                                            carbamoyl group 17299
                                              carboxamide 17299
                                                monocarboxylic acid amide 15008
                                                  arenecarboxamide 7262
                                                    benzamides 7262
                                                      axitinib 7
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