Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1588455
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Thbs1
Name: thrombospondin 1
Acc ID: CHEBI:66910
Term: axitinib
Definition: An indazole substituted at position 3 by a 2-(pyridin-2-yl)vinyl group and at position 6 by a 2-(N-methylaminocarboxy)phenylsulfanyl group. Used for the treatment of advanced renal cell carcinoma after failure of a first line systemic treatment.
Chemical ID: MESH:C503983
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Thbs1multiple interactionsEXP 6480464CTDaxitinib inhibits the reaction [Cyclophosphamide results in increased expression of THBS1 protein]PMID:18202011
Go Back to source page   Continue to Ontology report