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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:lasofoxifene
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Accession:CHEBI:135938 term browser browse the term
Definition:A member of the class of tetralins that is 5,6,7,8-tetrahydronaphthalen-2-ol in which the hydrogens at positions 5 and 6 are replaced by 4-[2-(pyrrolidin-1-yl)ethoxy]phenyl and phenyl groups, respectively (the 5R,6S-stereoisomer). It is a selective estrogen receptor modulator indicated for the prevention and treatment of osteoporosis in post-menopausal women.
Synonyms:exact_synonym: (5R,6S)-6-phenyl-5-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-5,6,7,8-tetrahydronaphthalen-2-ol
 related_synonym: (-)-cis-(5R,6S)-6-phenyl-5-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-5,6,7,8-tetrahydronaphthalen-2-ol;   (-)-cis-5,6,7,8-tetrahydro-6-phenyl-5-(p-(2-(1-pyrrolidinyl)ethoxy)phenyl)-2-naphthol;   CP-336,156;   CP-336156;   Formula=C28H31NO2;   InChI=1S/C28H31NO2/c30-24-11-15-27-23(20-24)10-14-26(21-6-2-1-3-7-21)28(27)22-8-12-25(13-9-22)31-19-18-29-16-4-5-17-29/h1-3,6-9,11-13,15,20,26,28,30H,4-5,10,14,16-19H2/t26-,28+/m1/s1;   InChIKey=GXESHMAMLJKROZ-IAPPQJPRSA-N;   Oporia;   SMILES=[H][C@@]1(CCC2=CC(O)=CC=C2[C@@]1([H])C1=CC=C(OCCN2CCCC2)C=C1)C1=CC=CC=C1;   lasofoxifeno;   lasofoxifenum
 alt_id: CHEBI:41282
 xref: CAS:180916-16-9;   DrugBank:DB06202;   Drug_Central:4308
 xref_mesh: MESH:C111332
 xref: PDBeChem:C3D;   PMCID:PMC6553177;   PMID:10566027;   PMID:10746637;   PMID:11112634;   PMID:11316005;   PMID:15801869;   PMID:17456742;   PMID:19898646;   PMID:20181970;   PMID:20446861;   PMID:20568309;   PMID:20568310;   PMID:21080249;   PMID:23604900;   PMID:24275139;   PMID:26424839;   PMID:9528995;   Wikipedia:Lasofoxifene



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lasofoxifene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor increases expression EXP Lasofoxifene results in increased expression of AR protein CTD PMID:16837883 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Areg amphiregulin multiple interactions
increases expression
ISO Lasofoxifene inhibits the reaction [Estrogens, Conjugated (USP) results in increased expression of AREG mRNA]
Lasofoxifene results in increased expression of AREG mRNA
CTD PMID:19022889 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535
JBrowse link
G Defb1 defensin beta 1 multiple interactions ISO [Progesterone co-treated with Lasofoxifene] results in increased expression of DEFB1 mRNA CTD PMID:18367319 NCBI chr16:70,298,862...70,313,604
Ensembl chr16:70,298,863...70,313,604
JBrowse link
G Esr2 estrogen receptor 2 increases expression EXP Lasofoxifene results in increased expression of ESR2 protein CTD PMID:16837883 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 increases expression
multiple interactions
ISO Lasofoxifene results in increased expression of IDO1 mRNA
Lasofoxifene inhibits the reaction [Estradiol results in increased expression of IDO1 mRNA]
CTD PMID:18367319 NCBI chr16:67,430,654...67,442,726
Ensembl chr16:67,430,578...67,442,730
JBrowse link
G Mmp2 matrix metallopeptidase 2 increases activity EXP Lasofoxifene results in increased activity of MMP2 protein CTD PMID:15576828 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G P2ry14 purinergic receptor P2Y14 multiple interactions ISO Lasofoxifene inhibits the reaction [Estradiol results in increased expression of P2RY14 mRNA] CTD PMID:18367319 NCBI chr 2:143,372,697...143,413,213
Ensembl chr 2:143,372,697...143,413,141
JBrowse link
G Pgr progesterone receptor increases expression EXP Lasofoxifene results in increased expression of PGR protein CTD PMID:16837883 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Spink1 serine peptidase inhibitor, Kazal type 1 multiple interactions ISO [Progesterone co-treated with Lasofoxifene] results in increased expression of SPINK1 mRNA CTD PMID:18367319 NCBI chr18:35,870,723...35,882,693
Ensembl chr18:35,824,550...35,882,642
JBrowse link

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  CHEBI ontology 19918
    role 19894
      application 19729
        pharmaceutical 19565
          drug 19565
            antineoplastic agent 17770
              lasofoxifene 9
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  CHEBI ontology 19918
    subatomic particle 19916
      composite particle 19916
        hadron 19916
          baryon 19916
            nucleon 19916
              atomic nucleus 19916
                atom 19916
                  main group element atom 19866
                    p-block element atom 19866
                      carbon group element atom 19811
                        carbon atom 19806
                          organic molecular entity 19806
                            organic molecule 19758
                              organic cyclic compound 19565
                                carbocyclic compound 18616
                                  carbopolycyclic compound 17208
                                    carbobicyclic compound 5886
                                      naphthalenes 3851
                                        hydroxynaphthalene 258
                                          naphthols 249
                                            lasofoxifene 9
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