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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:lasofoxifene
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Accession:CHEBI:135938 term browser browse the term
Definition:A member of the class of tetralins that is 5,6,7,8-tetrahydronaphthalen-2-ol in which the hydrogens at positions 5 and 6 are replaced by 4-[2-(pyrrolidin-1-yl)ethoxy]phenyl and phenyl groups, respectively (the 5R,6S-stereoisomer). It is a selective estrogen receptor modulator indicated for the prevention and treatment of osteoporosis in post-menopausal women.
Synonyms:exact_synonym: (5R,6S)-6-phenyl-5-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-5,6,7,8-tetrahydronaphthalen-2-ol
 related_synonym: (-)-cis-(5R,6S)-6-phenyl-5-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-5,6,7,8-tetrahydronaphthalen-2-ol;   (-)-cis-5,6,7,8-tetrahydro-6-phenyl-5-(p-(2-(1-pyrrolidinyl)ethoxy)phenyl)-2-naphthol;   CP-336,156;   CP-336156;   Formula=C28H31NO2;   InChI=1S/C28H31NO2/c30-24-11-15-27-23(20-24)10-14-26(21-6-2-1-3-7-21)28(27)22-8-12-25(13-9-22)31-19-18-29-16-4-5-17-29/h1-3,6-9,11-13,15,20,26,28,30H,4-5,10,14,16-19H2/t26-,28+/m1/s1;   InChIKey=GXESHMAMLJKROZ-IAPPQJPRSA-N;   Oporia;   SMILES=[H][C@@]1(CCC2=CC(O)=CC=C2[C@@]1([H])C1=CC=C(OCCN2CCCC2)C=C1)C1=CC=CC=C1;   lasofoxifeno;   lasofoxifenum
 alt_id: CHEBI:41282
 xref: CAS:180916-16-9;   DrugBank:DB06202;   Drug_Central:4308
 xref_mesh: MESH:C111332
 xref: PDBeChem:C3D;   PMCID:PMC6553177;   PMID:10566027;   PMID:10746637;   PMID:11112634;   PMID:11316005;   PMID:15801869;   PMID:17456742;   PMID:19898646;   PMID:20181970;   PMID:20446861;   PMID:20568309;   PMID:20568310;   PMID:21080249;   PMID:23604900;   PMID:24275139;   PMID:26424839;   PMID:9528995;   Wikipedia:Lasofoxifene



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lasofoxifene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor increases expression EXP Lasofoxifene results in increased expression of AR protein CTD PMID:16837883 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Areg amphiregulin multiple interactions
increases expression
ISO Lasofoxifene inhibits the reaction [Estrogens, Conjugated (USP) results in increased expression of AREG mRNA]
Lasofoxifene results in increased expression of AREG mRNA
CTD PMID:19022889 NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535
JBrowse link
G Defb1 defensin beta 1 multiple interactions ISO [Progesterone co-treated with Lasofoxifene] results in increased expression of DEFB1 mRNA CTD PMID:18367319 NCBI chr16:70,298,862...70,313,604
Ensembl chr16:70,298,863...70,313,604
JBrowse link
G Esr2 estrogen receptor 2 increases expression EXP Lasofoxifene results in increased expression of ESR2 protein CTD PMID:16837883 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 increases expression
multiple interactions
ISO Lasofoxifene results in increased expression of IDO1 mRNA
Lasofoxifene inhibits the reaction [Estradiol results in increased expression of IDO1 mRNA]
CTD PMID:18367319 NCBI chr16:67,430,684...67,442,459
Ensembl chr16:67,430,578...67,442,730
JBrowse link
G Mmp2 matrix metallopeptidase 2 increases activity EXP Lasofoxifene results in increased activity of MMP2 protein CTD PMID:15576828 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G P2ry14 purinergic receptor P2Y14 multiple interactions ISO Lasofoxifene inhibits the reaction [Estradiol results in increased expression of P2RY14 mRNA] CTD PMID:18367319 NCBI chr 2:143,372,697...143,413,213
Ensembl chr 2:143,372,697...143,413,141
JBrowse link
G Pgr progesterone receptor increases expression EXP Lasofoxifene results in increased expression of PGR protein CTD PMID:16837883 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Spink1 serine peptidase inhibitor, Kazal type 1 multiple interactions ISO [Progesterone co-treated with Lasofoxifene] results in increased expression of SPINK1 mRNA CTD PMID:18367319 NCBI chr18:35,870,723...35,882,693
Ensembl chr18:35,824,550...35,882,642
JBrowse link

Term paths to the root
Path 1
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  CHEBI ontology 19800
    role 19751
      application 19498
        pharmaceutical 19356
          drug 19356
            antineoplastic agent 17359
              lasofoxifene 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic molecule 19549
                              organic cyclic compound 19343
                                carbocyclic compound 18316
                                  carbopolycyclic compound 17029
                                    carbobicyclic compound 5822
                                      naphthalenes 3766
                                        hydroxynaphthalene 255
                                          naphthols 246
                                            lasofoxifene 9
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