CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: lasofoxifene
Accession: CHEBI:135938
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Definition: A member of the class of tetralins that is 5,6,7,8-tetrahydronaphthalen-2-ol in which the hydrogens at positions 5 and 6 are replaced by 4-[2-(pyrrolidin-1-yl)ethoxy]phenyl and phenyl groups, respectively (the 5R,6S-stereoisomer). It is a selective estrogen receptor modulator indicated for the prevention and treatment of osteoporosis in post-menopausal women.
Synonyms: exact_synonym: (5R,6S)-6-phenyl-5-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-5,6,7,8-tetrahydronaphthalen-2-ol
related_synonym: (-)-cis-(5R,6S)-6-phenyl-5-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-5,6,7,8-tetrahydronaphthalen-2-ol; (-)-cis-5,6,7,8-tetrahydro-6-phenyl-5-(p-(2-(1-pyrrolidinyl)ethoxy)phenyl)-2-naphthol; CP-336,156; CP-336156; Formula=C28H31NO2; InChI=1S/C28H31NO2/c30-24-11-15-27-23(20-24)10-14-26(21-6-2-1-3-7-21)28(27)22-8-12-25(13-9-22)31-19-18-29-16-4-5-17-29/h1-3,6-9,11-13,15,20,26,28,30H,4-5,10,14,16-19H2/t26-,28+/m1/s1; InChIKey=GXESHMAMLJKROZ-IAPPQJPRSA-N; Oporia; SMILES=[H][C@@]1(CCC2=CC(O)=CC=C2[C@@]1([H])C1=CC=C(OCCN2CCCC2)C=C1)C1=CC=CC=C1; lasofoxifeno; lasofoxifenum
alt_id: CHEBI:41282
xref: CAS:180916-16-9; DrugBank:DB06202; Drug_Central:4308
xref_mesh: MESH:C111332
xref: PDBeChem:C3D; PMCID:PMC6553177; PMID:10566027; PMID:10746637; PMID:11112634; PMID:11316005; PMID:15801869; PMID:17456742; PMID:19898646; PMID:20181970; PMID:20446861; PMID:20568309; PMID:20568310; PMID:21080249; PMID:23604900; PMID:24275139; PMID:26424839; PMID:9528995; Wikipedia:Lasofoxifene
G
Ar
androgen receptor
increases expression
EXP
Lasofoxifene results in increased expression of AR protein
CTD
PMID:16837883
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
G
Areg
amphiregulin
multiple interactions increases expression
ISO
Lasofoxifene inhibits the reaction [Estrogens, Conjugated (USP) results in increased expression of AREG mRNA] Lasofoxifene results in increased expression of AREG mRNA
CTD
PMID:19022889
NCBI chr14:16,972,185...16,981,443
Ensembl chr14:16,972,187...16,981,535
G
Defb1
defensin beta 1
multiple interactions
ISO
[Progesterone co-treated with Lasofoxifene] results in increased expression of DEFB1 mRNA
CTD
PMID:18367319
NCBI chr16:70,298,862...70,313,604
Ensembl chr16:70,298,863...70,313,604
G
Esr2
estrogen receptor 2
increases expression
EXP
Lasofoxifene results in increased expression of ESR2 protein
CTD
PMID:16837883
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
G
Ido1
indoleamine 2,3-dioxygenase 1
increases expression multiple interactions
ISO
Lasofoxifene results in increased expression of IDO1 mRNA Lasofoxifene inhibits the reaction [Estradiol results in increased expression of IDO1 mRNA]
CTD
PMID:18367319
NCBI chr16:67,430,654...67,442,726
Ensembl chr16:67,430,578...67,442,730
G
Mmp2
matrix metallopeptidase 2
increases activity
EXP
Lasofoxifene results in increased activity of MMP2 protein
CTD
PMID:15576828
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
G
P2ry14
purinergic receptor P2Y14
multiple interactions
ISO
Lasofoxifene inhibits the reaction [Estradiol results in increased expression of P2RY14 mRNA]
CTD
PMID:18367319
NCBI chr 2:143,372,697...143,413,213
Ensembl chr 2:143,372,697...143,413,141
G
Pgr
progesterone receptor
increases expression
EXP
Lasofoxifene results in increased expression of PGR protein
CTD
PMID:16837883
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
G
Spink1
serine peptidase inhibitor, Kazal type 1
multiple interactions
ISO
[Progesterone co-treated with Lasofoxifene] results in increased expression of SPINK1 mRNA
CTD
PMID:18367319
NCBI chr18:35,870,723...35,882,693
Ensembl chr18:35,824,550...35,882,642
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