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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:lasofoxifene
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Accession:CHEBI:135938 term browser browse the term
Definition:A member of the class of tetralins that is 5,6,7,8-tetrahydronaphthalen-2-ol in which the hydrogens at positions 5 and 6 are replaced by 4-[2-(pyrrolidin-1-yl)ethoxy]phenyl and phenyl groups, respectively (the 5R,6S-stereoisomer). It is a selective estrogen receptor modulator indicated for the prevention and treatment of osteoporosis in post-menopausal women.
Synonyms:exact_synonym: (5R,6S)-6-phenyl-5-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-5,6,7,8-tetrahydronaphthalen-2-ol
 related_synonym: (-)-cis-(5R,6S)-6-phenyl-5-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-5,6,7,8-tetrahydronaphthalen-2-ol;   (-)-cis-5,6,7,8-tetrahydro-6-phenyl-5-(p-(2-(1-pyrrolidinyl)ethoxy)phenyl)-2-naphthol;   CP-336,156;   CP-336156;   Formula=C28H31NO2;   InChI=1S/C28H31NO2/c30-24-11-15-27-23(20-24)10-14-26(21-6-2-1-3-7-21)28(27)22-8-12-25(13-9-22)31-19-18-29-16-4-5-17-29/h1-3,6-9,11-13,15,20,26,28,30H,4-5,10,14,16-19H2/t26-,28+/m1/s1;   InChIKey=GXESHMAMLJKROZ-IAPPQJPRSA-N;   Oporia;   SMILES=[H][C@@]1(CCC2=CC(O)=CC=C2[C@@]1([H])C1=CC=C(OCCN2CCCC2)C=C1)C1=CC=CC=C1;   lasofoxifeno;   lasofoxifenum
 alt_id: CHEBI:41282
 xref: CAS:180916-16-9;   DrugBank:DB06202;   Drug_Central:4308
 xref_mesh: MESH:C111332
 xref: PDBeChem:C3D;   PMCID:PMC6553177;   PMID:10566027;   PMID:10746637;   PMID:11112634;   PMID:11316005;   PMID:15801869;   PMID:17456742;   PMID:19898646;   PMID:20181970;   PMID:20446861;   PMID:20568309;   PMID:20568310;   PMID:21080249;   PMID:23604900;   PMID:24275139;   PMID:26424839;   PMID:9528995;   Wikipedia:Lasofoxifene


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lasofoxifene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor increases expression EXP Lasofoxifene results in increased expression of AR protein CTD PMID:16837883 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Areg amphiregulin multiple interactions
increases expression
ISO Lasofoxifene inhibits the reaction [Estrogens, Conjugated (USP) results in increased expression of AREG mRNA]
Lasofoxifene results in increased expression of AREG mRNA
CTD PMID:19022889 NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179
JBrowse link
G Defb1 defensin beta 1 multiple interactions ISO [Progesterone co-treated with Lasofoxifene] results in increased expression of DEFB1 mRNA CTD PMID:18367319 NCBI chr16:75,294,385...75,309,127
Ensembl chr16:75,294,376...75,309,176
JBrowse link
G Esr2 estrogen receptor 2 increases expression EXP Lasofoxifene results in increased expression of ESR2 protein CTD PMID:16837883 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 increases expression
multiple interactions
ISO Lasofoxifene results in increased expression of IDO1 mRNA
Lasofoxifene inhibits the reaction [Estradiol results in increased expression of IDO1 mRNA]
CTD PMID:18367319 NCBI chr16:72,216,326...72,228,098
Ensembl chr16:72,216,326...72,228,098
JBrowse link
G Mmp2 matrix metallopeptidase 2 increases activity EXP Lasofoxifene results in increased activity of MMP2 protein CTD PMID:15576828 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G P2ry14 purinergic receptor P2Y14 multiple interactions ISO Lasofoxifene inhibits the reaction [Estradiol results in increased expression of P2RY14 mRNA] CTD PMID:18367319 NCBI chr 2:149,331,948...149,379,336
Ensembl chr 2:149,331,948...149,347,796
JBrowse link
G Pgr progesterone receptor increases expression EXP Lasofoxifene results in increased expression of PGR protein CTD PMID:16837883 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Spink1 serine peptidase inhibitor, Kazal type 1 multiple interactions ISO [Progesterone co-treated with Lasofoxifene] results in increased expression of SPINK1 mRNA CTD PMID:18367319 NCBI chr18:38,221,919...38,242,092
Ensembl chr18:38,221,681...38,242,119
JBrowse link

Term paths to the root
Path 1
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  CHEBI ontology 19883
    role 19833
      application 19505
        pharmaceutical 19375
          drug 19375
            antineoplastic agent 17034
              lasofoxifene 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19883
    subatomic particle 19881
      composite particle 19881
        hadron 19881
          baryon 19881
            nucleon 19881
              atomic nucleus 19881
                atom 19881
                  main group element atom 19771
                    p-block element atom 19771
                      carbon group element atom 19679
                        carbon atom 19668
                          organic molecular entity 19668
                            organic molecule 19596
                              organic cyclic compound 19407
                                carbocyclic compound 18312
                                  carbopolycyclic compound 17079
                                    carbobicyclic compound 5818
                                      naphthalenes 3757
                                        hydroxynaphthalene 245
                                          naphthols 238
                                            lasofoxifene 9
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