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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2149
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Areg
Name: amphiregulin
Acc ID: CHEBI:135938
Term: lasofoxifene
Definition: A member of the class of tetralins that is 5,6,7,8-tetrahydronaphthalen-2-ol in which the hydrogens at positions 5 and 6 are replaced by 4-[2-(pyrrolidin-1-yl)ethoxy]phenyl and phenyl groups, respectively (the 5R,6S-stereoisomer). It is a selective estrogen receptor modulator indicated for the prevention and treatment of osteoporosis in post-menopausal women.
Chemical ID: MESH:C111332
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aregincreases expressionISORGD:7363826480464CTDLasofoxifene results in increased expression of AREG mRNA

PMID:19022889
Aregmultiple interactionsISORGD:7363826480464CTDLasofoxifene inhibits the reaction [Estrogens Conjugated USP results in increased expression of AREG mRNA]

PMID:19022889
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