Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   


RGD ID: 619943
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Defb1
Name: defensin beta 1
Acc ID: CHEBI:135938
Term: lasofoxifene
Definition: A member of the class of tetralins that is 5,6,7,8-tetrahydronaphthalen-2-ol in which the hydrogens at positions 5 and 6 are replaced by 4-[2-(pyrrolidin-1-yl)ethoxy]phenyl and phenyl groups, respectively (the 5R,6S-stereoisomer). It is a selective estrogen receptor modulator indicated for the prevention and treatment of osteoporosis in post-menopausal women.
Chemical ID: MESH:C111332
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Defb1multiple interactionsISORGD:7326906480464CTD[Progesterone co-treated with Lasofoxifene] results in increased expression of DEFB1 mRNA

Go Back to source page   Continue to Ontology report