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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:procainamide
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Accession:CHEBI:8428 term browser browse the term
Definition:A benzamide that is 4-aminobenzamide substituted on the amide N by a 2-(diethylamino)ethyl group. It is a pharmaceutical antiarrhythmic agent used for the medical treatment of cardiac arrhythmias.
Synonyms:exact_synonym: 4-amino-N-[2-(diethylamino)ethyl]benzamide
 related_synonym: Biocoryl;   Formula=C13H21N3O;   InChI=1S/C13H21N3O/c1-3-16(4-2)10-9-15-13(17)11-5-7-12(14)8-6-11/h5-8H,3-4,9-10,14H2,1-2H3,(H,15,17);   InChIKey=REQCZEXYDRLIBE-UHFFFAOYSA-N;   SMILES=CCN(CC)CCNC(=O)c1ccc(N)cc1;   p-Amino-N-(2-diethylaminoethyl)benzamide;   p-Aminobenzoic diethylaminoethylamide;   procainamida;   procainamidum
 xref: CAS:51-06-9;   DrugBank:DB01035;   Drug_Central:2270;   KEGG:C07401;   KEGG:D08421;   LINCS:LSM-3681
 xref_mesh: MESH:D011342
 xref: PMID:16230360;   PMID:2494958;   PMID:29276243;   PMID:29494946;   Reaxys:2214285;   Wikipedia:Procainamide


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procainamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases expression ISO Procainamide results in increased expression of CDKN2A protein CTD PMID:17938735 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149 		JBrowse link
G Foxp3 forkhead box P3 increases expression ISO Procainamide results in increased expression of FOXP3 protein CTD PMID:19109157 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838 		JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 increases expression ISO
EXP		 Procainamide results in increased expression of HSD11B2 mRNA CTD PMID:15489962 NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions ISO Procainamide binds to and results in decreased activity of KCNH2 protein CTD PMID:15272206 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO [[MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of Procainamide] which results in increased expression of MPO protein modified form; [MPO protein co-treated with Hydrogen Peroxide co-treated with 5,5-dimethyl-1-pyrroline-1-oxide] results in increased metabolism of Procainamide CTD PMID:20199096 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Nat1 N-acetyltransferase 1 increases acetylation ISO NAT1 protein results in increased acetylation of Procainamide CTD PMID:16003948 NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Nat2 N-acetyltransferase 2 affects acetylation ISO NAT2 protein affects the acetylation of Procainamide CTD PMID:15930747 NCBI chr16:22,207,362...22,238,513
Ensembl chr16:22,208,194...22,238,520 		JBrowse link
G Rassf1 Ras association domain family member 1 increases expression ISO Procainamide results in increased expression of RASSF1 protein CTD PMID:17938735 NCBI chr 8:108,225,023...108,236,164
Ensembl chr 8:108,225,023...108,236,164 		JBrowse link
G Slc22a16 solute carrier family 22 member 16 multiple interactions ISO Procainamide inhibits the reaction [SLC22A16 protein results in increased uptake of Tetraethylammonium] CTD PMID:15963465 NCBI chr20:43,972,808...44,068,447
Ensembl chr20:43,972,836...44,065,019 		JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions ISO Procainamide inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium analog] CTD PMID:10966924 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612 		JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Procainamide analog inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Procainamide inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637 		JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Procainamide analog inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Procainamide inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904 		JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Procainamide results in increased expression of WIPI1 mRNA CTD PMID:15342952 NCBI chr10:94,542,946...94,580,174
Ensembl chr10:94,542,946...94,579,846 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19890
    role 19839
      application 19703
        pharmaceutical 19518
          drug 19538
            cardiovascular drug 8649
              anti-arrhythmia drug 1542
                procainamide 13
                  procainamide hydrochloride 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19890
    subatomic particle 19867
      composite particle 19888
        hadron 19888
          baryon 19888
            nucleon 19867
              atomic nucleus 19888
                atom 19888
                  main group element atom 19806
                    p-block element atom 19806
                      carbon group element atom 19746
                        carbon atom 19743
                          organic molecular entity 19743
                            heteroorganic entity 19502
                              organochalcogen compound 19264
                                organooxygen compound 19180
                                  carbon oxoacid 18666
                                    carboxylic acid 18663
                                      carboacyl group 17715
                                        univalent carboacyl group 17690
                                          carbamoyl group 17566
                                            carboxamide 17566
                                              monocarboxylic acid amide 15721
                                                arenecarboxamide 8254
                                                  benzamides 8254
                                                    procainamide 13
                                                      procainamide hydrochloride 0
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