CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: pirenzepine
Accession: CHEBI:8247
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Definition: A pyridobenzodiazepine that has formula C19H21N5O2.
Synonyms: exact_synonym: 11-[(4-methylpiperazin-1-yl)acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
related_synonym: 11-((4-Methyl-1-piperazinyl)acetyl)-5,11-dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-one; Formula=C19H21N5O2; InChI=1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26); InChIKey=RMHMFHUVIITRHF-UHFFFAOYSA-N; SMILES=CN1CCN(CC1)CC(=O)N1c2ccccc2C(=O)Nc2cccnc12; pirenzepina; pirenzepinum
xref: Beilstein:628987; CAS:28797-61-7; DrugBank:DB00670; Drug_Central:2200; KEGG:C07508; KEGG:D08389; LINCS:LSM-4001
xref_mesh: MESH:D010890
xref: Patent:FR1505795
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Avpr1a
arginine vasopressin receptor 1A
multiple interactions
EXP
Pirenzepine binds to and results in decreased activity of AVPR1A protein
CTD
PMID:11553362
NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215
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Cd40
CD40 molecule
multiple interactions
ISO
Pirenzepine inhibits the reaction [Carbachol results in increased expression of CD40 protein]
CTD
PMID:16879495
NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
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Chrm1
cholinergic receptor, muscarinic 1
multiple interactions affects binding
ISO EXP
brucine affects the reaction [Pirenzepine analog binds to CHRM1 protein]; Pirenzepine inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]; Pirenzepine inhibits the reaction [Scopolamine Derivatives binds to CHRM1 protein] Pirenzepine binds to and results in decreased activity of CHRM1 protein Pirenzepine binds to and results in decreased activity of CHRM1 protein; Pirenzepine inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]
CTD
PMID:8032910 PMID:9846649 PMID:11306684 PMID:12646291 PMID:15294002 PMID:18316702 More...
NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356
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Chrm5
cholinergic receptor, muscarinic 5
multiple interactions
ISO
Pirenzepine inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein]
CTD
PMID:9846649
NCBI chr 3:99,284,846...99,337,252
Ensembl chr 3:99,284,846...99,337,252
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Egr1
early growth response 1
multiple interactions
EXP
Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of EGR1 mRNA]
CTD
PMID:7968354
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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Egr2
early growth response 2
multiple interactions
EXP
Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of EGR2 mRNA]
CTD
PMID:7968354
NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions
EXP
Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA]
CTD
PMID:7968354
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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Junb
JunB proto-oncogene, AP-1 transcription factor subunit
multiple interactions
EXP
Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA]
CTD
PMID:7968354
NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
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