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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:anti-ulcer drug
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Accession:CHEBI:49201 term browser browse the term
Definition:One of various classes of drugs with different action mechanisms used to treat or ameliorate peptic ulcer or irritation of the gastrointestinal tract.
Synonyms:related_synonym: anti-ulcer agent;   anti-ulcer agents;   anti-ulcer drugs



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16,16-dimethylprostaglandin E2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
ISO 16,16-Dimethylprostaglandin E2 results in increased phosphorylation of AKT1 protein
EGFR affects the reaction [16,16-Dimethylprostaglandin E2 results in increased phosphorylation of AKT1 protein]
CTD PMID:15578100 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases response to substance
affects localization
ISO BAX results in increased susceptibility to 16,16-Dimethylprostaglandin E2
16,16-Dimethylprostaglandin E2 affects the localization of BAX protein
CTD PMID:15578100 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO EGFR affects the reaction [16,16-Dimethylprostaglandin E2 results in increased phosphorylation of AKT1 protein] CTD PMID:15578100 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase increases activity ISO 16,16-Dimethylprostaglandin E2 results in increased activity of HPGD protein CTD PMID:14736730 NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP 16,16-Dimethylprostaglandin E2 inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:11686837 PMID:11855677 PMID:11991626 PMID:18306037 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP 16,16-Dimethylprostaglandin E2 inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]; 16,16-Dimethylprostaglandin E2 inhibits the reaction [Indomethacin results in increased expression of NOS2 mRNA] CTD PMID:11686837 PMID:11855677 PMID:11991626 PMID:15610444 PMID:18306037 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO
EXP
Flurbiprofen inhibits the reaction [16,16-Dimethylprostaglandin E2 results in increased expression of PTGS2 mRNA]
16,16-Dimethylprostaglandin E2 inhibits the reaction [SC 560 results in increased expression of PTGS2 mRNA]
CTD PMID:9099957 PMID:15610444 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 16,16-Dimethylprostaglandin E2 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF] CTD PMID:9298541 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
5'-hydroxyomeprazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression EXP 5-hydroxymethylomeprazole results in increased expression of CYP1A1 protein CTD PMID:10103034 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
amlexanox term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha multiple interactions ISO amlexanox inhibits the reaction [Palmitic Acid results in increased expression of ACACA mRNA] CTD PMID:32905826 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 multiple interactions
decreases expression
ISO amlexanox inhibits the reaction [Palmitic Acid results in increased expression of ADGRE1 mRNA]
amlexanox results in decreased expression of ADGRE1 mRNA
CTD PMID:32905826 NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000
JBrowse link
G Arg1 arginase 1 multiple interactions ISO amlexanox affects the reaction [Palmitic Acid affects the expression of ARG1 mRNA]; amlexanox inhibits the reaction [Palmitic Acid results in decreased expression of ARG1 protein] CTD PMID:32905826 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
decreases expression
ISO amlexanox inhibits the reaction [Acetaminophen results in increased expression of BAX protein]; amlexanox inhibits the reaction [Palmitic Acid results in increased expression of BAX protein]
amlexanox results in decreased expression of BAX protein
CTD PMID:31697998 PMID:32905826 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO amlexanox inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]; amlexanox inhibits the reaction [Palmitic Acid results in decreased expression of BCL2 protein] CTD PMID:31697998 PMID:32905826 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Casp3 caspase 3 multiple interactions ISO amlexanox inhibits the reaction [Palmitic Acid results in increased cleavage of CASP3 protein] CTD PMID:32905826 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO amlexanox inhibits the reaction [Acetaminophen results in increased expression of CCL2 mRNA] CTD PMID:31697998 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cd14 CD14 molecule multiple interactions ISO amlexanox inhibits the reaction [Palmitic Acid results in increased expression of CD14 mRNA] CTD PMID:32905826 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
JBrowse link
G Cd68 Cd68 molecule multiple interactions ISO amlexanox inhibits the reaction [Palmitic Acid results in increased expression of CD68 mRNA] CTD PMID:32905826 NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A multiple interactions ISO amlexanox inhibits the reaction [Palmitic Acid results in decreased expression of CPT1A mRNA] CTD PMID:32905826 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO amlexanox inhibits the reaction [Acetaminophen results in increased expression of CXCL2 mRNA] CTD PMID:31697998 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 multiple interactions ISO amlexanox inhibits the reaction [Acetaminophen results in increased expression of CXCL1 mRNA] CTD PMID:31697998 NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO amlexanox inhibits the reaction [Palmitic Acid results in increased expression of CYP2E1 mRNA]; amlexanox inhibits the reaction [Palmitic Acid results in increased expression of CYP2E1 protein] CTD PMID:32905826 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 multiple interactions ISO amlexanox inhibits the reaction [Palmitic Acid results in increased expression of DGAT1 mRNA] CTD PMID:32905826 NCBI chr 7:108,223,860...108,235,413
Ensembl chr 7:108,218,524...108,234,299
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO amlexanox inhibits the reaction [Palmitic Acid results in increased expression of FASN mRNA] CTD PMID:32905826 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fgf1 fibroblast growth factor 1 multiple interactions ISO [amlexanox binds to FGF1 protein] inhibits the reaction [cupric chloride results in increased oxidation of FGF1 protein]; amlexanox binds to and results in increased stability of and results in decreased secretion of FGF1 protein; amlexanox inhibits the reaction [FGF1 protein binds to FGF1 protein] CTD PMID:16300395 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression
ISO [Acetaminophen co-treated with amlexanox co-treated with dorsomorphin] affects the expression of GCLC mRNA; [Acetaminophen co-treated with amlexanox] affects the expression of GCLC mRNA
amlexanox results in increased expression of GCLC mRNA
CTD PMID:31697998 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO [Acetaminophen co-treated with amlexanox co-treated with dorsomorphin] affects the expression of GCLM mRNA CTD PMID:31697998 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO amlexanox inhibits the reaction [Acetaminophen results in increased expression of GPT protein]; dorsomorphin inhibits the reaction [amlexanox inhibits the reaction [Acetaminophen results in increased expression of GPT protein]] CTD PMID:31697998 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gpx1 glutathione peroxidase 1 affects localization ISO amlexanox affects the localization of GPX1 mRNA mutant form CTD PMID:28743738 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO [amlexanox co-treated with Acetaminophen] results in increased expression of HMOX1 mRNA; [amlexanox co-treated with Palmitic Acid] results in increased expression of HMOX1 mRNA; amlexanox promotes the reaction [Acetaminophen results in increased expression of HMOX1 protein]; dorsomorphin inhibits the reaction [[amlexanox co-treated with Acetaminophen] results in increased expression of HMOX1 mRNA]
amlexanox results in increased expression of HMOX1 mRNA
CTD PMID:31697998 PMID:32905826 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO amlexanox inhibits the reaction [Palmitic Acid results in increased expression of IFNB1 mRNA]; amlexanox inhibits the reaction [Paraquat results in increased secretion of IFNB1 protein] CTD PMID:32763286 PMID:32905826 NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523
JBrowse link
G Ikbke inhibitor of nuclear factor kappa B kinase subunit epsilon decreases activity
multiple interactions
ISO amlexanox results in decreased activity of IKBKE protein
amlexanox inhibits the reaction [Acetaminophen results in increased phosphorylation of IKBKE protein]; amlexanox inhibits the reaction [Palmitic Acid results in increased phosphorylation of IKBKE protein]
CTD PMID:25321315 PMID:31697998 PMID:32905826 NCBI chr13:42,712,154...42,738,470
Ensembl chr13:42,712,159...42,737,143
JBrowse link
G Il10 interleukin 10 multiple interactions ISO amlexanox affects the reaction [Palmitic Acid affects the expression of IL10 mRNA]; amlexanox inhibits the reaction [Palmitic Acid results in decreased expression of IL10 protein] CTD PMID:32905826 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO amlexanox inhibits the reaction [Acetaminophen results in increased expression of IL1B mRNA]; amlexanox inhibits the reaction [Palmitic Acid results in increased expression of IL1B mRNA]; amlexanox inhibits the reaction [Palmitic Acid results in increased secretion of IL1B protein]; amlexanox inhibits the reaction [Paraquat results in increased secretion of IL1B protein] CTD PMID:31697998 PMID:32763286 PMID:32905826 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO amlexanox inhibits the reaction [Acetaminophen results in increased expression of IL6 mRNA]; amlexanox inhibits the reaction [Palmitic Acid results in increased expression of IL6 mRNA]; amlexanox inhibits the reaction [Palmitic Acid results in increased secretion of IL6 protein] CTD PMID:31697998 PMID:32905826 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Irf3 interferon regulatory factor 3 multiple interactions ISO amlexanox inhibits the reaction [Palmitic Acid results in increased phosphorylation of IRF3 protein]; amlexanox inhibits the reaction [Paraquat affects the localization of IRF3 protein] CTD PMID:32763286 PMID:32905826 NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression
multiple interactions
ISO amlexanox results in increased expression of NFE2L2 protein
[Acetaminophen co-treated with amlexanox] results in increased expression of NFE2L2 protein; amlexanox inhibits the reaction [Acetaminophen results in decreased expression of NFE2L2 protein]; dorsomorphin inhibits the reaction [amlexanox inhibits the reaction [Acetaminophen results in decreased expression of NFE2L2 protein]]
CTD PMID:31697998 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO amlexanox inhibits the reaction [Palmitic Acid results in increased expression of NOS2 mRNA]; amlexanox inhibits the reaction [Palmitic Acid results in increased expression of NOS2 protein]; mifobate inhibits the reaction [amlexanox inhibits the reaction [Palmitic Acid results in increased expression of NOS2 mRNA]] CTD PMID:32905826 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO dorsomorphin inhibits the reaction [[Acetaminophen co-treated with amlexanox] affects the expression of NQO1 mRNA] CTD PMID:31697998 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO amlexanox inhibits the reaction [Palmitic Acid results in decreased expression of PPARA mRNA]; amlexanox inhibits the reaction [Palmitic Acid results in decreased expression of PPARA protein]; amlexanox promotes the reaction [Palmitic Acid results in increased expression of PPARA protein] CTD PMID:32905826 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 increases phosphorylation
multiple interactions
ISO amlexanox results in increased phosphorylation of PRKAA1 protein
[Acetaminophen co-treated with amlexanox] results in increased phosphorylation of PRKAA1 protein; amlexanox inhibits the reaction [Acetaminophen results in decreased phosphorylation of PRKAA1 protein]; dorsomorphin inhibits the reaction [amlexanox inhibits the reaction [Acetaminophen results in decreased phosphorylation of PRKAA1 protein]]
CTD PMID:31697998 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO amlexanox inhibits the reaction [Acetaminophen results in increased phosphorylation of RELA protein]; amlexanox inhibits the reaction [Paraquat affects the localization of RELA protein] CTD PMID:31697998 PMID:32763286 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression
multiple interactions
ISO amlexanox results in decreased expression of SREBF1 mRNA
amlexanox inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 mRNA]
CTD PMID:32905826 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Tbk1 TANK-binding kinase 1 decreases activity
decreases phosphorylation
multiple interactions
ISO amlexanox results in decreased activity of TBK1 protein
amlexanox results in decreased phosphorylation of TBK1 protein
amlexanox inhibits the reaction [Acetaminophen results in increased phosphorylation of TBK1 protein]; amlexanox inhibits the reaction [Palmitic Acid results in increased phosphorylation of TBK1 protein]; amlexanox inhibits the reaction [Paraquat results in increased phosphorylation of TBK1 protein]
CTD PMID:25321315 PMID:31697998 PMID:32763286 PMID:32905826 NCBI chr 7:57,077,830...57,110,868
Ensembl chr 7:57,077,830...57,110,892
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO amlexanox inhibits the reaction [Acetaminophen results in increased expression of TNF mRNA]; amlexanox inhibits the reaction [Palmitic Acid results in increased expression of TNF mRNA]; amlexanox inhibits the reaction [Palmitic Acid results in increased secretion of TNF protein] CTD PMID:31697998 PMID:32905826 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Upf1 UPF1, RNA helicase and ATPase affects localization ISO amlexanox affects the localization of UPF1 protein CTD PMID:28743738 NCBI chr16:19,076,594...19,097,365
Ensembl chr16:19,076,322...19,096,568
JBrowse link
artesunate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions
decreases expression
ISO Deferoxamine inhibits the reaction [Artesunate results in decreased expression of ACTA2 mRNA]
Artesunate results in decreased expression of ACTA2 mRNA; Artesunate results in decreased expression of ACTA2 protein
Artesunate inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]
CTD PMID:30551460 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 affects localization ISO artesunate affects the localization of AIFM1 protein CTD PMID:24704559 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256
JBrowse link
G Ar androgen receptor multiple interactions ISO artesunate binds to and results in decreased activity of AR protein CTD PMID:25752796 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Atg12 autophagy related 12 increases expression ISO Artesunate results in increased expression of ATG12 mRNA CTD PMID:30551460 NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418
JBrowse link
G Atg3 autophagy related 3 increases expression ISO Artesunate results in increased expression of ATG3 mRNA CTD PMID:30551460 NCBI chr11:55,624,914...55,653,249
Ensembl chr11:55,624,917...55,653,224
JBrowse link
G Atg5 autophagy related 5 increases expression ISO Artesunate results in increased expression of ATG5 mRNA CTD PMID:30551460 NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO
EXP
Artesunate results in increased expression of BAX protein
[1,2-Dimethylhydrazine co-treated with artesunate] results in increased expression of BAX protein
CTD PMID:24704559 PMID:29031619 PMID:33002460 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO
EXP
Artesunate results in decreased expression of BCL2 protein
3-methyladenine inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; acadesine promotes the reaction [Artesunate results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; dorsomorphin inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; Sirolimus promotes the reaction [Artesunate results in decreased expression of BCL2 protein]
[1,2-Dimethylhydrazine co-treated with artesunate] results in decreased expression of BCL2 protein
CTD PMID:24704559 PMID:29031619 PMID:33002460 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bst1 bone marrow stromal cell antigen 1 increases response to substance ISO BST1 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr14:67,253,706...67,270,203
Ensembl chr14:67,252,998...67,270,180
JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage
multiple interactions
ISO artesunate results in increased activity of CASP3 protein
Artesunate results in increased cleavage of CASP3 protein
3-methyladenine inhibits the reaction [Artesunate results in increased cleavage of CASP3 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [Artesunate results in increased cleavage of CASP3 protein]; Sirolimus promotes the reaction [Artesunate results in increased cleavage of CASP3 protein]
CTD PMID:19513562 PMID:24704559 PMID:33002460 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 affects expression ISO artesunate affects the expression of CASP9 protein CTD PMID:24704559 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase increases expression
decreases response to substance
ISO artesunate results in increased expression of CAT protein
CAT protein results in decreased susceptibility to artesunate
CTD PMID:19513562 PMID:20144594 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cct2 chaperonin containing TCP1 subunit 2 decreases response to substance ISO CCT2 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 7:52,692,725...52,705,478
Ensembl chr 7:52,692,725...52,706,944
JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions
increases phosphorylation
ISO APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of CHEK1 protein] CTD PMID:31664825 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions
increases phosphorylation
ISO APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of CHEK2 protein] CTD PMID:31664825 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
JBrowse link
G Clip4 CAP-GLY domain containing linker protein family, member 4 increases response to substance ISO CLIP4 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr 6:23,616,280...23,697,625
Ensembl chr 6:23,616,281...23,677,874
JBrowse link
G Coq8a coenzyme Q8A decreases response to substance ISO COQ8A mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr13:91,904,731...91,933,588
Ensembl chr13:91,904,739...91,931,431
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CTNNB1 protein] CTD PMID:29031619 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Dbh dopamine beta-hydroxylase increases response to substance ISO DBH mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248
JBrowse link
G Des desmin multiple interactions
decreases expression
ISO Deferoxamine inhibits the reaction [Artesunate results in decreased expression of DES mRNA]
Artesunate results in decreased expression of DES mRNA; Artesunate results in decreased expression of DES protein
CTD PMID:30551460 NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO artesunate binds to and results in decreased activity of ESR1 protein CTD PMID:25752796 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO artesunate results in increased expression of FAS protein CTD PMID:19513562 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Flna filamin A increases response to substance ISO FLNA mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr  X:152,007,758...152,034,266
Ensembl chr  X:152,007,758...152,031,052
JBrowse link
G Fn1 fibronectin 1 multiple interactions
decreases expression
ISO Deferoxamine inhibits the reaction [Artesunate results in decreased expression of FN1 mRNA]
Artesunate results in decreased expression of FN1 mRNA; Artesunate results in decreased expression of FN1 protein
CTD PMID:30551460 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Fth1 ferritin heavy chain 1 decreases expression
multiple interactions
ISO Artesunate results in decreased expression of FTH1 mRNA; Artesunate results in decreased expression of FTH1 protein
Chloroquine inhibits the reaction [Artesunate results in decreased expression of FTH1 mRNA]
CTD PMID:30551460 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
JBrowse link
G Fzd7 frizzled class receptor 7 increases response to substance ISO FZD7 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr 9:60,931,433...60,934,252
Ensembl chr 9:60,930,875...60,935,781
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit affects response to substance
decreases response to substance
ISO GCLC mRNA affects the susceptibility to artesunate
GCLC mRNA results in decreased susceptibility to artesunate
CTD PMID:15796179 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit decreases response to substance ISO GCLM mRNA results in decreased susceptibility to artesunate CTD PMID:15796179 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gpx4 glutathione peroxidase 4 decreases activity
multiple interactions
ISO Artesunate results in decreased activity of GPX4 protein
Artesunate inhibits the reaction [Carbon Tetrachloride results in increased expression of GPX4 protein]
CTD PMID:30551460 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
JBrowse link
G Gstm4 glutathione S-transferase mu 4 affects response to substance ISO GSTM4 mRNA affects the susceptibility to artesunate CTD PMID:15796179 NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases expression ISO artesunate results in decreased expression of GSTP1 protein CTD PMID:19513562 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Gstt2 glutathione S-transferase theta 2 affects response to substance ISO GSTT2 mRNA affects the susceptibility to artesunate CTD PMID:15796179 NCBI chr20:12,819,617...12,823,288
Ensembl chr20:12,819,170...12,823,288
JBrowse link
G Gstz1 glutathione S-transferase zeta 1 affects response to substance ISO GSTZ1 mRNA affects the susceptibility to artesunate CTD PMID:15796179 NCBI chr 6:106,794,594...106,805,284
Ensembl chr 6:106,794,074...106,805,284
JBrowse link
G H2ax H2A.X variant histone multiple interactions
increases phosphorylation
ISO APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of H2AX protein] CTD PMID:31664825 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Artesunate inhibits the reaction [Ethanol results in increased expression of IL1B protein]; Artesunate inhibits the reaction [Glucose results in increased expression of IL1B mRNA]; Artesunate inhibits the reaction [Glucose results in increased secretion of IL1B protein] CTD PMID:27474069 PMID:30031708 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions EXP Artesunate inhibits the reaction [Ethanol results in increased expression of IL6 protein]; Artesunate inhibits the reaction [Glucose results in increased expression of IL6 mRNA]; Artesunate inhibits the reaction [Glucose results in increased secretion of IL6 protein] CTD PMID:27474069 PMID:30031708 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Itgb1 integrin subunit beta 1 increases response to substance ISO ITGB1 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases lipidation
ISO 3-methyladenine inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; acadesine promotes the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; Acetylcysteine inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; dorsomorphin inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; Sirolimus promotes the reaction [Artesunate results in increased lipidation of MAP1LC3B protein] CTD PMID:33002460 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Mgst3 microsomal glutathione S-transferase 3 affects response to substance ISO MGST3 mRNA affects the susceptibility to artesunate CTD PMID:15796179 NCBI chr13:79,526,541...79,547,479
Ensembl chr13:79,526,541...79,547,411
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions EXP artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MKI67 protein] CTD PMID:29031619 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
EXP
ISO
artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MMP9 protein]
Chloroquine inhibits the reaction [Artesunate results in decreased expression of MMP9 mRNA]
CTD PMID:29031619 PMID:30551460 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP artesunate inhibits the reaction [Ethanol results in increased activity of MPO protein] CTD PMID:27474069 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mthfd2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase decreases response to substance ISO MTHFD2 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases phosphorylation
ISO acadesine promotes the reaction [Artesunate results in decreased phosphorylation of MTOR protein]; Acetylcysteine inhibits the reaction [Artesunate results in decreased phosphorylation of MTOR protein]; dorsomorphin inhibits the reaction [Artesunate results in decreased phosphorylation of MTOR protein] CTD PMID:33002460 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions EXP artesunate inhibits the reaction [Glucose results in increased expression of MYD88 protein] CTD PMID:30031708 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
JBrowse link
G Naca nascent polypeptide associated complex subunit alpha decreases response to substance ISO NACA mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 7:468,862...481,992
Ensembl chr 7:469,723...481,992
JBrowse link
G Nckap1 NCK-associated protein 1 increases response to substance ISO NCKAP1 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr 3:65,417,450...65,491,769
Ensembl chr 3:65,417,453...65,492,217
JBrowse link
G Ncoa4 nuclear receptor coactivator 4 multiple interactions
decreases expression
ISO Chloroquine inhibits the reaction [Artesunate results in decreased expression of NCOA4 mRNA]
Artesunate results in decreased expression of NCOA4 mRNA; Artesunate results in decreased expression of NCOA4 protein
CTD PMID:30551460 NCBI chr16:7,389,222...7,409,564
Ensembl chr16:7,366,542...7,409,641
Ensembl chr16:7,366,542...7,409,641
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects localization ISO artesunate affects the localization of NFE2L2 protein CTD PMID:26340163 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP artesunate inhibits the reaction [Glucose results in increased expression of NLRP3 protein] CTD PMID:30031708 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO Artesunate results in increased cleavage of PARP1 protein
3-methyladenine inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; acadesine promotes the reaction [Artesunate results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; dorsomorphin inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; Sirolimus promotes the reaction [Artesunate results in increased cleavage of PARP1 protein]
CTD PMID:24704559 PMID:33002460 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PCNA protein] CTD PMID:29031619 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pgr progesterone receptor multiple interactions ISO artesunate binds to and results in increased activity of PGR protein CTD PMID:25752796 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Carbon Tetrachloride results in increased susceptibility to Artesunate] which results in increased expression of PTGS2 mRNA; [Carbon Tetrachloride results in increased susceptibility to Artesunate] which results in increased expression of PTGS2 protein CTD PMID:30551460 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP artesunate inhibits the reaction [Ethanol results in increased expression of RELA protein]; artesunate inhibits the reaction [Glucose results in increased phosphorylation of RELA protein] CTD PMID:27474069 PMID:30031708 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rpa2 replication protein A2 increases phosphorylation ISO Artesunate results in increased phosphorylation of RPA2 protein CTD PMID:31664825 NCBI chr 5:144,976,789...144,989,445
Ensembl chr 5:144,976,748...144,987,350
JBrowse link
G Rpl41 ribosomal protein L41 decreases response to substance ISO RPL41 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 7:977,885...978,965 JBrowse link
G Rpl6 ribosomal protein L6 decreases response to substance ISO RPL6 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr12:35,347,493...35,352,011
Ensembl chr12:35,347,497...35,351,921
JBrowse link
G Rpl7 ribosomal protein L7 decreases response to substance ISO RPL7 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 5:3,217,184...3,220,192 JBrowse link
G Rps12 ribosomal protein S12 decreases response to substance ISO RPS12 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 1:21,680,854...21,683,010
Ensembl chr 1:21,680,852...21,683,014
JBrowse link
G Rps15a ribosomal protein S15a decreases response to substance ISO RPS15A mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 1:172,420,151...172,427,021
Ensembl chr 1:172,419,761...172,426,995
JBrowse link
G Rps6 ribosomal protein S6 decreases response to substance ISO RPS6 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602
JBrowse link
G Slc25a19 solute carrier family 25 member 19 decreases response to substance ISO SLC25A19 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr10:100,853,554...100,867,517
Ensembl chr10:100,847,168...100,867,447
JBrowse link
G Sp1 Sp1 transcription factor decreases expression ISO artesunate results in decreased expression of SP1 protein CTD PMID:19513562 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
decreases expression
ISO Chloroquine inhibits the reaction [Artesunate results in decreased expression of SQSTM1 protein]
Artesunate results in decreased expression of SQSTM1 mRNA; Artesunate results in decreased expression of SQSTM1 protein
CTD PMID:30551460 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Srsf2 serine and arginine rich splicing factor 2 decreases response to substance ISO SRSF2 mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr10:102,052,158...102,055,365
Ensembl chr10:102,052,314...102,055,338
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression
multiple interactions
ISO Artesunate results in increased expression of TIMP1 mRNA
Chloroquine inhibits the reaction [Artesunate results in increased expression of TIMP1 mRNA]
CTD PMID:30551460 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP artesunate inhibits the reaction [Glucose results in increased expression of TLR4 protein] CTD PMID:30031708 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP artesunate inhibits the reaction [Ethanol results in increased expression of TNF protein]; artesunate inhibits the reaction [Glucose results in increased expression of TNF mRNA]; artesunate inhibits the reaction [Glucose results in increased secretion of TNF protein] CTD PMID:27474069 PMID:30031708 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions
ISO Artesunate results in increased expression of TP53 protein
Artesunate inhibits the reaction [TPT1 protein binds to TP53 protein]
CTD PMID:33259807 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tpt1 tumor protein, translationally-controlled 1 affects response to substance
multiple interactions
ISO TPT1 protein affects the susceptibility to artesunate
Artesunate binds to and results in decreased expression of TPT1 protein; Artesunate inhibits the reaction [TPT1 protein binds to TP53 protein]
CTD PMID:15878303 PMID:33259807 NCBI chr15:51,156,728...51,159,629
Ensembl chr15:51,146,154...51,159,625
JBrowse link
G Tufm Tu translation elongation factor, mitochondrial decreases response to substance ISO TUFM mRNA results in decreased susceptibility to artesunate CTD PMID:20144594 NCBI chr 1:181,073,788...181,077,395
Ensembl chr 1:181,073,788...181,077,395
JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 increases phosphorylation
multiple interactions
ISO Artesunate results in increased phosphorylation of ULK1 protein
acadesine promotes the reaction [Artesunate results in increased phosphorylation of ULK1 protein]; Acetylcysteine inhibits the reaction [Artesunate results in increased phosphorylation of ULK1 protein]; dorsomorphin inhibits the reaction [Artesunate results in increased phosphorylation of ULK1 protein]
CTD PMID:33002460 NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of VEGFA protein] CTD PMID:29031619 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Yy1 YY1 transcription factor decreases expression ISO artesunate results in decreased expression of YY1 protein CTD PMID:19513562 NCBI chr 6:127,706,739...127,736,499
Ensembl chr 6:127,707,596...127,732,747
JBrowse link
G Zbtb4 zinc finger and BTB domain containing 4 increases response to substance ISO ZBTB4 mRNA results in increased susceptibility to artesunate CTD PMID:20144594 NCBI chr10:54,480,698...54,501,492
Ensembl chr10:54,485,071...54,501,492
JBrowse link
balsalazide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mpo myeloperoxidase decreases activity ISO balsalazide results in decreased activity of MPO protein CTD PMID:19296261 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
cimetidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 affects transport
multiple interactions
ISO ABCG2 protein affects the transport of Cimetidine
Cimetidine inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]
CTD PMID:15365089 PMID:15722455 PMID:26907376 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Adh1c alcohol dehydrogenase 1C (class I), gamma polypeptide multiple interactions ISO Cimetidine inhibits the reaction [ADH1C protein results in increased oxidation of Ethanol] CTD PMID:23220590 NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892
JBrowse link
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide multiple interactions ISO Cimetidine inhibits the reaction [ADH4 protein results in increased oxidation of Ethanol] CTD PMID:23220590 NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591
JBrowse link
G Adh5 alcohol dehydrogenase 5 (class III), chi polypeptide multiple interactions ISO Cimetidine inhibits the reaction [ADH5 protein results in increased oxidation of S-hydroxymethylglutathione] CTD PMID:23220590 NCBI chr 2:226,975,184...226,987,591
Ensembl chr 2:226,947,466...226,987,591
JBrowse link
G Adh7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide multiple interactions ISO Cimetidine inhibits the reaction [ADH7 protein results in increased oxidation of Ethanol] CTD PMID:23220590 NCBI chr 2:226,748,724...226,763,183
Ensembl chr 2:226,741,788...226,763,182
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO Cimetidine promotes the reaction [Metformin results in decreased expression of ADIPOQ mRNA] CTD PMID:20956498 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Ahr aryl hydrocarbon receptor affects expression
multiple interactions
ISO Cimetidine affects the expression of AHR protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of AHR protein
CTD PMID:22733800 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 multiple interactions ISO Cimetidine inhibits the reaction [ALDH1A1 protein results in increased oxidation of Acetaldehyde] CTD PMID:23220590 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 multiple interactions ISO Cimetidine inhibits the reaction [ALDH3A1 protein results in increased oxidation of benzaldehyde] CTD PMID:23220590 NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases activity ISO Cimetidine results in increased activity of APAF1 protein CTD PMID:17273750 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
JBrowse link
G Ar androgen receptor multiple interactions
decreases expression
ISO
EXP
Cimetidine inhibits the reaction [Dihydrotestosterone binds to AR protein]
Cimetidine results in decreased expression of AR protein
CTD PMID:6835285 PMID:26021711 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO Cimetidine results in increased expression of BAX protein
Cimetidine inhibits the reaction [Ethanol results in increased expression of BAX protein]
CTD PMID:20127008 PMID:27983966 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO Cimetidine results in decreased expression of BCL2 protein
Cimetidine inhibits the reaction [Ethanol results in decreased expression of BCL2 protein]
CTD PMID:20127008 PMID:27983966 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Casp1 caspase 1 increases activity
multiple interactions
ISO Cimetidine results in increased activity of CASP1 protein
CASP1 protein affects the reaction [Cimetidine results in increased expression of IL18 protein]
CTD PMID:16723495 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp12 caspase 12 multiple interactions ISO Cimetidine inhibits the reaction [Ethanol results in increased expression of CASP12 protein] CTD PMID:27983966 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases expression
ISO
EXP
Cimetidine results in increased activity of CASP3 protein
Cimetidine inhibits the reaction [Ethanol results in increased expression of CASP3 protein]
Cimetidine results in increased expression of CASP3 protein
CTD PMID:17273750 PMID:20127008 PMID:26021711 PMID:27983966 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 increases activity ISO Cimetidine results in increased activity of CASP7 protein CTD PMID:17273750 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 increases activity ISO Cimetidine results in increased activity of CASP8 protein CTD PMID:17273750 PMID:20127008 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity ISO Cimetidine results in increased activity of CASP9 protein CTD PMID:17273750 PMID:20127008 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Cimetidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 protein] CTD PMID:12107048 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cd14 CD14 molecule decreases expression ISO Cimetidine results in decreased expression of CD14 protein CTD PMID:11556524 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
JBrowse link
G Cst3 cystatin C multiple interactions ISO Cimetidine inhibits the reaction [Cisplatin results in increased expression of CST3] CTD PMID:22525860 NCBI chr 3:136,336,923...136,340,796
Ensembl chr 3:136,336,920...136,340,822
JBrowse link
G Ctsd cathepsin D decreases activity EXP Cimetidine results in decreased activity of CTSD protein CTD PMID:12903910 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
JBrowse link
G Ctsl cathepsin L decreases activity EXP Cimetidine results in decreased activity of CTSL protein CTD PMID:12903910 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases expression
decreases activity
ISO Cimetidine inhibits the reaction [Cocaine results in increased expression of CYP1A1 protein]
Cimetidine results in decreased expression of CYP1A1 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of CYP1A1 protein
Cimetidine results in decreased activity of CYP1A1 protein
CTD PMID:11856816 PMID:22733800 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity
ISO Cimetidine inhibits the reaction [CYP1A2 protein results in increased metabolism of Tacrine]; NADP promotes the reaction [Cimetidine inhibits the reaction [CYP1A2 protein results in increased metabolism of Tacrine]]; styrofoam analog promotes the reaction [Cimetidine results in decreased activity of CYP1A2 protein] CTD PMID:7946932 PMID:19909766 PMID:31863871 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 decreases expression
multiple interactions
decreases activity
ISO Cimetidine results in decreased expression of CYP2B6 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of CYP2B6 protein
Cimetidine results in decreased activity of CYP2B6 protein
CTD PMID:22733800 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions
decreases activity
EXP
ISO
Cimetidine inhibits the reaction [CYP2C11 protein results in increased glutathionylation of lamotrigine]
Cimetidine results in decreased activity of CYP2C9 protein
styrofoam analog promotes the reaction [Cimetidine results in decreased activity of CYP2C9 protein]
CTD PMID:19909766 PMID:19961160 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity
multiple interactions
ISO
EXP
Cimetidine results in decreased activity of CYP2D6 protein
Cimetidine inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan]
styrofoam analog promotes the reaction [Cimetidine results in decreased activity of CYP2D6 protein]
CTD PMID:17651725 PMID:19909766 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression
multiple interactions
ISO Cimetidine results in decreased expression of CYP2E1 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of CYP2E1 protein
CTD PMID:22733800 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 multiple interactions ISO Cimetidine inhibits the reaction [Cocaine results in increased expression of CYP2J2 protein] CTD PMID:11856816 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
decreases expression
decreases activity
ISO [Monocrotophos co-treated with Cimetidine] results in increased expression of CYP3A4 protein; Cimetidine inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Nifedipine]; styrofoam analog promotes the reaction [Cimetidine results in decreased activity of CYP3A4 protein]
Cimetidine results in decreased expression of CYP3A4 protein
CTD PMID:2271712 PMID:16041596 PMID:18846481 PMID:19909766 PMID:22733800 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO Cimetidine inhibits the reaction [Ethanol results in increased expression of DDIT3 protein] CTD PMID:27983966 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO Cimetidine inhibits the reaction [EGFR protein results in increased phosphorylation of EGFR protein]
[Cimetidine results in decreased abundance of Cyclic AMP] inhibits the reaction [EGFR protein results in increased phosphorylation of EGFR protein]
CTD PMID:17295779 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Fshb follicle stimulating hormone subunit beta affects expression ISO Cimetidine affects the expression of FSHB protein CTD PMID:435711 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G Gast gastrin affects expression ISO Cimetidine affects the expression of GAST protein CTD PMID:12503773 NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496
JBrowse link
G Gstp1 glutathione S-transferase pi 1 affects expression
multiple interactions
ISO Cimetidine affects the expression of GSTP1 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of GSTP1 protein
CTD PMID:22733800 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP [piperine co-treated with Cimetidine co-treated with Pyruvates] inhibits the reaction [Puromycin Aminonucleoside results in increased expression of HMOX1 protein] CTD PMID:12806184 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hrh1 histamine receptor H 1 multiple interactions ISO Cimetidine inhibits the reaction [HRH1 results in decreased susceptibility to Morphine] CTD PMID:14569158 NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455
JBrowse link
G Hrh2 histamine receptor H 2 multiple interactions
decreases activity
increases expression
ISO
EXP
[Cimetidine binds to and results in decreased activity of HRH2 protein] results in decreased susceptibility to [Histamine co-treated with [Oxygen deficiency co-treated with Oxygen]]; [Cimetidine binds to and results in decreased activity of HRH2 protein] which affects the susceptibility to Metformin; [Cimetidine binds to and results in decreased activity of HRH2 protein] which results in decreased abundance of Cyclic AMP; Burimamide inhibits the reaction [[Cyclic AMP binds to and results in decreased activity of HRH2 protein] which results in decreased abundance of Cimetidine]; Cimetidine binds to and results in decreased activity of HRH2 protein; Cimetidine binds to and results in increased activity of HRH2 protein; Cimetidine inhibits the reaction [HRH2 protein promotes the reaction [Histamine results in increased expression of IL16 protein]]
Cimetidine results in decreased activity of HRH2 protein
[Cimetidine binds to and results in decreased activity of HRH2 protein] which results in decreased susceptibility to clobenpropit; Cimetidine binds to and results in decreased activity of HRH2 protein; Cimetidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH2 protein] which results in decreased susceptibility to Scopolamine]
Cimetidine binds to and results in increased activity of HRH2 protein; Cimetidine inhibits the reaction [HRH2 results in decreased susceptibility to Morphine]; HRH2 protein affects the reaction [Cimetidine results in increased expression of IL18 protein]
Cimetidine results in increased expression of HRH2 protein
CTD PMID:1912125 PMID:2461127 PMID:6522242 PMID:9681472 PMID:12235264 More... NCBI chr17:10,366,004...10,407,791
Ensembl chr17:10,368,298...10,407,631
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO Cimetidine inhibits the reaction [Ethanol results in increased expression of HSPA5 protein] CTD PMID:27983966 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO Cimetidine results in decreased expression of ICAM1 protein CTD PMID:17189874 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifng interferon gamma multiple interactions
increases expression
ISO Cimetidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]]
Cimetidine results in increased expression of IFNG mRNA; Cimetidine results in increased expression of IFNG protein
CTD PMID:10569698 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il16 interleukin 16 multiple interactions ISO Cimetidine inhibits the reaction [HRH2 protein promotes the reaction [Histamine results in increased expression of IL16 protein]] CTD PMID:12235264 NCBI chr 1:137,617,702...137,718,022
Ensembl chr 1:137,617,944...137,718,130
JBrowse link
G Il18 interleukin 18 multiple interactions
increases expression
ISO CASP1 protein affects the reaction [Cimetidine results in increased expression of IL18 protein]; Famotidine inhibits the reaction [Cimetidine results in increased expression of IL18 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Cimetidine results in increased expression of IL18 protein]; Ranitidine inhibits the reaction [Cimetidine results in increased expression of IL18 protein]
HRH2 protein affects the reaction [Cimetidine results in increased expression of IL18 protein]
CTD PMID:16723495 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Cimetidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Cimetidine inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein] CTD PMID:12065299 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Itga4 integrin subunit alpha 4 decreases expression ISO Cimetidine results in decreased expression of ITGA4 protein CTD PMID:11556524 NCBI chr 3:64,162,764...64,235,010
Ensembl chr 3:64,163,085...64,233,715
JBrowse link
G Itgax integrin subunit alpha X decreases expression ISO Cimetidine results in decreased expression of ITGAX protein CTD PMID:11556524 NCBI chr 1:182,709,653...182,740,709
Ensembl chr 1:182,719,609...182,740,698
JBrowse link
G Lrp1 LDL receptor related protein 1 decreases expression ISO Cimetidine results in decreased expression of LRP1 protein CTD PMID:11556524 NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910
JBrowse link
G Ncam1 neural cell adhesion molecule 1 decreases expression ISO Cimetidine results in decreased expression of NCAM mRNA; Cimetidine results in decreased expression of NCAM protein CTD PMID:17273750 NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO Cimetidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Cimetidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of NFKB1 protein] CTD PMID:12065299 PMID:12107048 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 decreases expression
multiple interactions
ISO Cimetidine results in decreased expression of NR1I2 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of NR1I2 protein
CTD PMID:22733800 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 decreases expression
multiple interactions
ISO Cimetidine results in decreased expression of NR1I3 protein
[Monocrotophos co-treated with Cimetidine] results in increased expression of NR1I3 protein
CTD PMID:22733800 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Ntf3 neurotrophin 3 multiple interactions EXP Cimetidine inhibits the reaction [Histamine results in increased expression of NTF3 protein] CTD PMID:21276809 NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596
JBrowse link
G Pde4b phosphodiesterase 4B multiple interactions ISO Cimetidine inhibits the reaction [Histamine results in increased expression of PDE4B mRNA] CTD PMID:11131300 NCBI chr 5:116,799,819...117,369,155
Ensembl chr 5:116,799,971...117,367,696
JBrowse link
G Prl prolactin affects expression ISO Cimetidine affects the expression of PRL protein CTD PMID:435711 PMID:9037573 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Prok1 prokineticin 1 decreases expression EXP Cimetidine results in decreased expression of PROK1 protein CTD PMID:26021711 NCBI chr 2:194,850,539...194,859,343
Ensembl chr 2:194,853,991...194,859,250
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Cimetidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Cimetidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of RELA protein]
Cimetidine inhibits the reaction [Ethanol results in increased expression of RELA protein]
CTD PMID:12065299 PMID:12107048 PMID:24300194 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Selp selectin P decreases expression ISO Cimetidine results in decreased expression of SELP protein CTD PMID:17189874 NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845
JBrowse link
G Slc22a1 solute carrier family 22 member 1 increases uptake
multiple interactions
EXP
ISO
SLC22A1 protein results in increased uptake of Cimetidine
Cimetidine inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]
CTD PMID:16006492 PMID:19357179 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions
increases transport
decreases response to substance
increases uptake
ISO
EXP
1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A2 protein results in increased uptake of Cimetidine]; Cimetidine inhibits the reaction [SLC22A2 protein affects the transport of Tetraethylammonium]; Cimetidine inhibits the reaction [SLC22A2 protein polymorphism results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Cimetidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Cimetidine inhibits the reaction [SLC22A2 protein results in increased uptake of Ethidium]; p-Aminohippuric Acid inhibits the reaction [SLC22A2 protein results in increased uptake of Cimetidine]
SLC22A2 protein results in increased transport of Cimetidine
SLC22A2 gene polymorphism results in decreased susceptibility to Cimetidine
CTD PMID:15496291 PMID:16006492 PMID:18230276 PMID:19357179 PMID:21599003 More... NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions
increases transport
ISO Cimetidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Cimetidine inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]; Cimetidine inhibits the reaction [SLC22A3 protein results in increased uptake of Metformin]
Cimetidine inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium]
SLC22A3 protein results in increased transport of Cimetidine
CTD PMID:10966924 PMID:18253050 PMID:19357179 PMID:21697722 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions
increases uptake
ISO 1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A6 protein results in increased uptake of Cimetidine]; Cimetidine inhibits the reaction [SLC22A6 protein affects the transport of p-Aminohippuric Acid]; p-Aminohippuric Acid inhibits the reaction [SLC22A6 protein results in increased uptake of Cimetidine] CTD PMID:15496291 PMID:16006492 PMID:16098483 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
JBrowse link
G Slc22a7 solute carrier family 22 member 7 increases uptake
multiple interactions
ISO SLC22A7 protein results in increased uptake of Cimetidine
Cimetidine inhibits the reaction [SLC22A7 protein results in increased uptake of Glutarates]
CTD PMID:12065749 PMID:16006492 NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921
JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions
increases uptake
affects transport
ISO
EXP
Cimetidine inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Probenecid inhibits the reaction [SLC22A8 protein affects the transport of Cimetidine]
SLC22A8 protein results in increased uptake of Cimetidine
Cimetidine inhibits the reaction [SLC22A8 protein results in increased uptake of p-Aminohippuric Acid]
estradiol-17 beta-glucuronide inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; estrone sulfate inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; Famotidine inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; p-Aminohippuric Acid inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; Penicillin G inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; Probenecid inhibits the reaction [SLC22A8 protein affects the transport of Cimetidine]; Probenecid promotes the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; Ranitidine inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]
CTD PMID:10224140 PMID:11306713 PMID:15100168 PMID:15319347 PMID:15496291 More... NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
JBrowse link
G Slc47a1 solute carrier family 47 member 1 affects transport
multiple interactions
decreases activity
ISO SLC47A1 protein affects the transport of Cimetidine
Cimetidine inhibits the reaction [SLC47A1 protein results in increased uptake of Cadmium]
Cimetidine inhibits the reaction [SLC47A1 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Cimetidine inhibits the reaction [SLC47A1 protein results in increased uptake of Cadmium]
Cimetidine results in decreased activity of SLC47A1 protein
CTD PMID:16928787 PMID:21599003 PMID:27871888 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Cimetidine inhibits the reaction [SLC47A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Cimetidine inhibits the reaction [SLC47A2 protein results in increased uptake of Cadmium] CTD PMID:21599003 PMID:27871888 NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904
JBrowse link
G Slc9a3 solute carrier family 9 member A3 multiple interactions EXP [piperine co-treated with Cimetidine co-treated with Pyruvates] inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of SLC9A3 protein] CTD PMID:12806184 NCBI chr 1:29,124,633...29,167,912
Ensembl chr 1:29,124,674...29,167,417
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Cimetidine inhibits the reaction [Dimaprit inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]
Cimetidine inhibits the reaction [Cocaine results in increased expression of TNF protein]
CTD PMID:9088875 PMID:11856816 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
cisapride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Cisapride results in decreased activity of ABCB11 protein CTD PMID:23956101 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions ISO Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA] CTD PMID:31150804 NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929
JBrowse link
G Ctsk cathepsin K multiple interactions ISO Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA] CTD PMID:31150804 NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases activity ISO Cisapride results in decreased activity of CYP2C9 protein CTD PMID:15306208 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
affects metabolic processing
affects chemical synthesis
decreases activity
ISO Cisapride inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]
CYP3A4 protein affects the metabolism of Cisapride
CYP3A4 protein affects the chemical synthesis of Cisapride metabolite
Cisapride results in decreased activity of CYP3A4 protein
CTD PMID:11717173 PMID:15306208 PMID:19299527 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Dcstamp dendrocyte expressed seven transmembrane protein multiple interactions ISO Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA] CTD PMID:31150804 NCBI chr 7:70,807,455...70,822,067
Ensembl chr 7:70,807,581...70,822,078
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA] CTD PMID:31150804 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity
affects localization
affects binding
ISO beta-Cyclodextrins analog inhibits the reaction [Cisapride results in decreased activity of KCNH2 protein]; Cisapride binds to and results in decreased activity of KCNH2 protein; Cisapride inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Cisapride affects the localization of KCNH2 protein mutant form
Cisapride binds to KCNH2 protein
CTD PMID:9395068 PMID:10531299 PMID:11005845 PMID:11741928 PMID:12388285 More... NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA] CTD PMID:31150804 NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028
JBrowse link
G Scn5a sodium voltage-gated channel alpha subunit 5 increases localization ISO Cisapride results in increased localization of SCN5A protein mutant form CTD PMID:16301357 NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Cisapride inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]; Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA]; Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA] CTD PMID:31150804 NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445
JBrowse link
diethyl malate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle affects expression ISO diethyl malate affects the expression of ACTA2 mRNA CTD PMID:24814887 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Actc1 actin, alpha, cardiac muscle 1 affects expression ISO diethyl malate affects the expression of ACTC1 mRNA CTD PMID:24814887 NCBI chr 3:100,811,987...100,817,523
Ensembl chr 3:100,811,987...100,817,523
JBrowse link
G Actn3 actinin alpha 3 affects expression ISO diethyl malate affects the expression of ACTN3 mRNA CTD PMID:24814887 NCBI chr 1:202,159,081...202,175,012
Ensembl chr 1:202,159,082...202,175,012
JBrowse link
G Adcy1 adenylate cyclase 1 affects expression ISO diethyl malate affects the expression of ADCY1 mRNA CTD PMID:24814887 NCBI chr14:81,911,240...82,020,594
Ensembl chr14:81,911,099...82,028,969
JBrowse link
G Adh1c alcohol dehydrogenase 1C (class I), gamma polypeptide affects expression ISO diethyl malate affects the expression of ADH1 mRNA CTD PMID:24814887 NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892
JBrowse link
G Agt angiotensinogen affects expression ISO diethyl malate affects the expression of AGT mRNA CTD PMID:24814887 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G C3 complement C3 affects expression ISO diethyl malate affects the expression of C3 mRNA CTD PMID:24814887 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
JBrowse link
G Cacnb2 calcium voltage-gated channel auxiliary subunit beta 2 affects expression ISO diethyl malate affects the expression of CACNB2 mRNA CTD PMID:24814887 NCBI chr17:77,564,630...77,910,000
Ensembl chr17:77,564,460...77,909,106
JBrowse link
G Cacnb4 calcium voltage-gated channel auxiliary subunit beta 4 affects expression ISO diethyl malate affects the expression of CACNB4 mRNA CTD PMID:24814887 NCBI chr 3:36,906,771...37,169,165
Ensembl chr 3:36,910,427...37,168,944
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions
affects expression
ISO S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of CAMK2A mRNA] CTD PMID:24814887 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
JBrowse link
G Cbr2 carbonyl reductase 2 affects expression ISO diethyl malate affects the expression of CBR2 mRNA CTD PMID:24814887 NCBI chr10:106,008,535...106,012,838
Ensembl chr10:105,991,589...106,013,001
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 affects expression ISO diethyl malate affects the expression of CCL20 mRNA CTD PMID:24814887 NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 affects expression ISO diethyl malate affects the expression of CCL7 mRNA CTD PMID:24814887 NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
JBrowse link
G Ccl9 C-C motif chemokine ligand 9 affects expression ISO diethyl malate affects the expression of CCL6 mRNA CTD PMID:24814887 NCBI chr10:68,366,486...68,371,408
Ensembl chr10:68,366,487...68,371,369
JBrowse link
G Col11a1 collagen type XI alpha 1 chain affects expression ISO diethyl malate affects the expression of COL11A1 mRNA CTD PMID:24814887 NCBI chr 2:201,820,715...202,013,853
Ensembl chr 2:201,820,715...202,013,853
JBrowse link
G Col2a1 collagen type II alpha 1 chain affects expression ISO diethyl malate affects the expression of COL2A1 mRNA CTD PMID:24814887 NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546
JBrowse link
G Col3a1 collagen type III alpha 1 chain affects expression ISO diethyl malate affects the expression of COL3A1 mRNA CTD PMID:24814887 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
JBrowse link
G Col6a1 collagen type VI alpha 1 chain affects expression ISO diethyl malate affects the expression of COL6A1 mRNA CTD PMID:24814887 NCBI chr20:11,906,105...11,924,599
Ensembl chr20:11,905,957...11,924,597
JBrowse link
G Comp cartilage oligomeric matrix protein affects expression ISO diethyl malate affects the expression of COMP mRNA CTD PMID:24814887 NCBI chr16:19,047,206...19,055,584
Ensembl chr16:19,047,207...19,055,845
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 affects expression
multiple interactions
ISO diethyl malate affects the expression of CXCL12 mRNA
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of CXCL12 mRNA]
CTD PMID:24814887 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 affects expression ISO diethyl malate affects the expression of CXCL1 mRNA CTD PMID:24814887 NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cxcl6 C-X-C motif chemokine ligand 6 affects expression ISO diethyl malate affects the expression of CXCL5 mRNA CTD PMID:24814887 NCBI chr14:17,310,790...17,312,250
Ensembl chr14:17,310,426...17,313,093
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 affects expression ISO diethyl malate affects the expression of CYP2J9 mRNA CTD PMID:24814887 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
JBrowse link
G Dapk2 death-associated protein kinase 2 affects expression ISO diethyl malate affects the expression of DAPK2 mRNA CTD PMID:24814887 NCBI chr 8:66,706,536...66,825,567
Ensembl chr 8:66,706,609...66,825,567
JBrowse link
G Dhrs3 dehydrogenase/reductase 3 affects expression ISO diethyl malate affects the expression of DHRS3 mRNA CTD PMID:24814887 NCBI chr 5:156,747,939...156,782,420
Ensembl chr 5:156,747,962...156,782,417
JBrowse link
G Dhx58 DEXH-box helicase 58 affects expression ISO diethyl malate affects the expression of DHX58 mRNA CTD PMID:24814887 NCBI chr10:85,620,352...85,631,776
Ensembl chr10:85,620,357...85,631,525
JBrowse link
G Edar ectodysplasin-A receptor affects expression ISO diethyl malate affects the expression of EDAR mRNA CTD PMID:24814887 NCBI chr20:26,587,836...26,666,543
Ensembl chr20:26,587,839...26,666,494
JBrowse link
G Ednra endothelin receptor type A affects expression ISO diethyl malate affects the expression of EDNRA mRNA CTD PMID:24814887 NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049
JBrowse link
G Epas1 endothelial PAS domain protein 1 affects expression ISO diethyl malate affects the expression of EPAS1 mRNA CTD PMID:24814887 NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228
JBrowse link
G Epha7 Eph receptor A7 affects expression ISO diethyl malate affects the expression of EPHA7 mRNA CTD PMID:24814887 NCBI chr 5:42,975,353...43,128,703
Ensembl chr 5:42,975,405...43,127,112
JBrowse link
G Ephb2 Eph receptor B2 affects expression ISO diethyl malate affects the expression of EPHB2 mRNA CTD PMID:24814887 NCBI chr 5:148,889,574...149,077,027
Ensembl chr 5:148,897,246...149,077,059
JBrowse link
G Ephb6 Eph receptor B6 affects expression ISO diethyl malate affects the expression of EPHB6 mRNA CTD PMID:24814887 NCBI chr 4:70,491,973...70,507,230
Ensembl chr 4:70,491,973...70,507,230
JBrowse link
G Fgf10 fibroblast growth factor 10 affects expression ISO diethyl malate affects the expression of FGF10 mRNA CTD PMID:24814887 NCBI chr 2:50,801,171...50,878,218
Ensembl chr 2:50,800,992...50,876,866
JBrowse link
G Fgf18 fibroblast growth factor 18 multiple interactions
affects expression
ISO S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of FGF18 mRNA] CTD PMID:24814887 NCBI chr10:17,706,011...17,737,702
Ensembl chr10:17,706,174...17,736,818
JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 affects expression ISO diethyl malate affects the expression of FGFR2 mRNA CTD PMID:24814887 NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626
JBrowse link
G Fst follistatin affects expression ISO diethyl malate affects the expression of FST mRNA CTD PMID:24814887 NCBI chr 2:46,123,260...46,130,584
Ensembl chr 2:46,123,439...46,130,571
JBrowse link
G Fzd2 frizzled class receptor 2 affects expression ISO diethyl malate affects the expression of FZD2 mRNA CTD PMID:24814887 NCBI chr10:87,561,866...87,563,776
Ensembl chr10:87,561,326...87,565,334
JBrowse link
G Fzd7 frizzled class receptor 7 affects expression ISO diethyl malate affects the expression of FZD7 mRNA CTD PMID:24814887 NCBI chr 9:60,931,433...60,934,252
Ensembl chr 9:60,930,875...60,935,781
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit affects expression ISO diethyl malate affects the expression of GCLC mRNA CTD PMID:24814887 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions
affects expression
ISO S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of GCLM mRNA] CTD PMID:24814887 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Ggt6 gamma-glutamyl transferase 6 affects expression ISO diethyl malate affects the expression of GGT6 mRNA CTD PMID:24814887 NCBI chr10:57,051,977...57,054,900
Ensembl chr10:57,051,825...57,067,260
JBrowse link
G Gli2 GLI family zinc finger 2 affects expression ISO diethyl malate affects the expression of GLI2 mRNA CTD PMID:24814887 NCBI chr13:29,946,882...30,163,589
Ensembl chr13:29,946,809...30,163,574
JBrowse link
G Gnao1 G protein subunit alpha o1 affects expression ISO diethyl malate affects the expression of GNAO1 mRNA CTD PMID:24814887 NCBI chr19:11,034,874...11,192,531
Ensembl chr19:11,035,956...11,192,493
JBrowse link
G Gng7 G protein subunit gamma 7 affects expression ISO diethyl malate affects the expression of GNG7 mRNA CTD PMID:24814887 NCBI chr 7:8,697,458...8,761,239
Ensembl chr 7:8,697,521...8,761,240
JBrowse link
G Gsr glutathione-disulfide reductase affects expression ISO diethyl malate affects the expression of GSR mRNA CTD PMID:24814887 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gss glutathione synthetase multiple interactions
affects expression
ISO S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of GSS mRNA] CTD PMID:24814887 NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 multiple interactions
affects expression
ISO S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of GSTA1 mRNA] CTD PMID:24814887 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
JBrowse link
G Gucy1a1 guanylate cyclase 1 soluble subunit alpha 1 affects expression ISO diethyl malate affects the expression of GUCY1A1 mRNA CTD PMID:24814887 NCBI chr 2:167,418,615...167,482,293
Ensembl chr 2:167,418,640...167,481,671
JBrowse link
G Gucy1b1 guanylate cyclase 1 soluble subunit beta 1 affects expression ISO diethyl malate affects the expression of GUCY1B1 mRNA CTD PMID:24814887 NCBI chr 2:167,348,824...167,398,983
Ensembl chr 2:167,348,825...167,398,916
JBrowse link
G Hck HCK proto-oncogene, Src family tyrosine kinase affects expression ISO diethyl malate affects the expression of HCK mRNA CTD PMID:24814887 NCBI chr 3:141,571,587...141,614,696
Ensembl chr 3:141,571,587...141,614,693
JBrowse link
G Hgf hepatocyte growth factor affects expression ISO diethyl malate affects the expression of HGF mRNA CTD PMID:24814887 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
JBrowse link
G Igf1 insulin-like growth factor 1 affects expression ISO diethyl malate affects the expression of IGF1 mRNA CTD PMID:24814887 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Il15 interleukin 15 affects expression ISO diethyl malate affects the expression of IL15 mRNA CTD PMID:24814887 NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820
JBrowse link
G Il18 interleukin 18 affects expression ISO diethyl malate affects the expression of IL18 mRNA CTD PMID:24814887 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Irag1 inositol 1,4,5-triphosphate receptor associated 1 affects expression ISO diethyl malate affects the expression of IRAG1 mRNA CTD PMID:24814887 NCBI chr 1:164,981,716...165,094,232
Ensembl chr 1:164,981,716...165,094,176
JBrowse link
G Irf7 interferon regulatory factor 7 affects expression ISO diethyl malate affects the expression of IRF7 mRNA CTD PMID:24814887 NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832
JBrowse link
G Isg15 ISG15 ubiquitin-like modifier affects expression ISO diethyl malate affects the expression of ISG15 mRNA CTD PMID:24814887 NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435
JBrowse link
G Itga11 integrin subunit alpha 11 affects expression ISO diethyl malate affects the expression of ITGA11 mRNA CTD PMID:24814887 NCBI chr 8:63,145,998...63,254,714
Ensembl chr 8:63,146,001...63,254,407
JBrowse link
G Itga3 integrin subunit alpha 3 affects expression ISO diethyl malate affects the expression of ITGA3 mRNA CTD PMID:24814887 NCBI chr10:79,990,160...80,022,206
Ensembl chr10:79,990,161...80,022,118
JBrowse link
G Kcnmb4 potassium calcium-activated channel subfamily M regulatory beta subunit 4 affects expression ISO diethyl malate affects the expression of KCNMB4 mRNA CTD PMID:24814887 NCBI chr 7:52,066,145...52,119,098
Ensembl chr 7:52,066,136...52,119,278
JBrowse link
G Lama1 laminin subunit alpha 1 affects expression ISO diethyl malate affects the expression of LAMA1 mRNA CTD PMID:24814887 NCBI chr 9:107,692,770...107,816,847
Ensembl chr 9:107,692,770...107,817,478
JBrowse link
G Lama4 laminin subunit alpha 4 affects expression ISO diethyl malate affects the expression of LAMA4 mRNA CTD PMID:24814887 NCBI chr20:42,392,268...42,533,347
Ensembl chr20:42,392,268...42,533,347
JBrowse link
G Mapk1 mitogen activated protein kinase 1 affects phosphorylation
multiple interactions
ISO diethyl malate affects the phosphorylation of MAPK1 protein
S-ethyl glutathione inhibits the reaction [diethyl malate affects the phosphorylation of MAPK1 protein]
CTD PMID:24814887 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 affects phosphorylation
multiple interactions
ISO diethyl malate affects the phosphorylation of MAPK3 protein
S-ethyl glutathione inhibits the reaction [diethyl malate affects the phosphorylation of MAPK3 protein]
CTD PMID:24814887 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Myl9 myosin light chain 9 affects expression ISO diethyl malate affects the expression of MYL9 mRNA CTD PMID:24814887 NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333
JBrowse link
G Odc1 ornithine decarboxylase 1 affects expression ISO diethyl malate affects the expression of ODC1 mRNA CTD PMID:24814887 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
JBrowse link
G Pdgfb platelet derived growth factor subunit B affects expression
multiple interactions
ISO diethyl malate affects the expression of PDGFB mRNA
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of PDGFB mRNA]
CTD PMID:24814887 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
JBrowse link
G Pdgfd platelet derived growth factor D affects expression ISO diethyl malate affects the expression of PDGFD mRNA CTD PMID:24814887 NCBI chr 8:3,488,448...3,722,395
Ensembl chr 8:3,488,423...3,722,395
JBrowse link
G Pf4 platelet factor 4 affects expression ISO diethyl malate affects the expression of PF4 mRNA CTD PMID:24814887 NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365
JBrowse link
G Pik3ip1 phosphoinositide-3-kinase interacting protein 1 affects expression ISO diethyl malate affects the expression of PIK3IP1 mRNA CTD PMID:24814887 NCBI chr14:78,204,668...78,216,616
Ensembl chr14:78,204,053...78,216,608
JBrowse link
G Plxnc1 plexin C1 affects expression ISO diethyl malate affects the expression of PLXNC1 mRNA CTD PMID:24814887 NCBI chr 7:29,390,038...29,543,985
Ensembl chr 7:29,390,048...29,543,779
JBrowse link
G Prkg1 protein kinase cGMP-dependent 1 affects expression ISO diethyl malate affects the expression of PRKG1 mRNA CTD PMID:24814887 NCBI chr 1:228,409,605...229,638,794
Ensembl chr 1:228,408,947...229,639,080
JBrowse link
G Ptgis prostaglandin I2 synthase affects expression ISO diethyl malate affects the expression of PTGIS mRNA CTD PMID:24814887 NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451
JBrowse link
G Ramp2 receptor activity modifying protein 2 affects expression ISO diethyl malate affects the expression of RAMP2 mRNA CTD PMID:24814887 NCBI chr10:86,187,366...86,190,692
Ensembl chr10:86,188,812...86,231,829
JBrowse link
G Rgs3 regulator of G-protein signaling 3 affects expression ISO diethyl malate affects the expression of RGS3 mRNA CTD PMID:24814887 NCBI chr 5:76,022,038...76,161,895
Ensembl chr 5:76,022,001...76,161,894
JBrowse link
G Rig1 RNA sensor RIG-1 affects expression ISO diethyl malate affects the expression of RIGI mRNA CTD PMID:24814887 NCBI chr 5:55,321,351...55,369,947
Ensembl chr 5:55,321,235...55,370,819
JBrowse link
G RT1-DMb RT1 class II, locus DMb affects expression ISO diethyl malate affects the expression of H2-DMB1 mRNA CTD PMID:24814887 NCBI chr20:4,693,102...4,700,340
Ensembl chr20:4,693,103...4,700,340
JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 affects expression ISO diethyl malate affects the expression of H2-M3 mRNA CTD PMID:24814887 NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117
JBrowse link
G Runx1t1 RUNX1 partner transcriptional co-repressor 1 affects expression ISO diethyl malate affects the expression of RUNX1T1 mRNA CTD PMID:24814887 NCBI chr 5:27,187,674...27,338,070
Ensembl chr 5:27,187,551...27,335,592
JBrowse link
G Sema3b semaphorin 3B affects expression ISO diethyl malate affects the expression of SEMA3B mRNA CTD PMID:24814887 NCBI chr 8:108,271,663...108,280,326
Ensembl chr 8:108,271,666...108,282,919
JBrowse link
G Sema4g semaphorin 4G affects expression ISO diethyl malate affects the expression of SEMA4G mRNA CTD PMID:24814887 NCBI chr 1:243,849,979...243,865,343
Ensembl chr 1:243,853,854...243,865,341
JBrowse link
G Sema5a semaphorin 5A affects expression ISO diethyl malate affects the expression of SEMA5A mRNA CTD PMID:24814887 NCBI chr 2:83,309,843...83,741,084
Ensembl chr 2:83,309,843...83,741,084
JBrowse link
G Stat1 signal transducer and activator of transcription 1 affects expression ISO diethyl malate affects the expression of STAT1 mRNA CTD PMID:24814887 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
JBrowse link
G Tgfb2 transforming growth factor, beta 2 affects expression
multiple interactions
ISO diethyl malate affects the expression of TGFB2 mRNA
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of TGFB2 mRNA]
CTD PMID:24814887 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
JBrowse link
G Thbs1 thrombospondin 1 affects expression ISO diethyl malate affects the expression of THBS1 mRNA CTD PMID:24814887 NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440
JBrowse link
G Thbs2 thrombospondin 2 affects expression ISO diethyl malate affects the expression of THBS2 mRNA CTD PMID:24814887 NCBI chr 1:55,670,394...55,699,789
Ensembl chr 1:55,670,394...55,699,789
JBrowse link
G Tnc tenascin C affects expression ISO diethyl malate affects the expression of TNC mRNA CTD PMID:24814887 NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B affects expression ISO diethyl malate affects the expression of TNFRSF11B mRNA CTD PMID:24814887 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538
JBrowse link
G Tnnt1 troponin T1, slow skeletal type affects expression ISO diethyl malate affects the expression of TNNT1 mRNA CTD PMID:24814887 NCBI chr 1:69,306,362...69,316,721
Ensembl chr 1:69,306,362...69,316,721
JBrowse link
G Tslp thymic stromal lymphopoietin affects expression ISO diethyl malate affects the expression of TSLP mRNA CTD PMID:24814887 NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548
JBrowse link
esomeprazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
ISO Mycophenolic Acid promotes the reaction [Esomeprazole results in increased expression of CYP1A1 mRNA] CTD PMID:25929522 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
eupatilin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CCL2 mRNA] CTD PMID:21565208 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases activity
ISO [[eupatilin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [eupatilin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam CTD PMID:31756459 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL1B mRNA] CTD PMID:21565208 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 mRNA] CTD PMID:21565208 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:21565208 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of NOS2 mRNA]; eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of NOS2 protein] CTD PMID:21565208 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of PTGS2 mRNA]; eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of PTGS2 protein] CTD PMID:21565208 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 affects the localization of RELA protein] CTD PMID:21565208 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions ISO eupatilin inhibits the reaction [SLC2A1 protein results in increased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose] CTD PMID:36870413 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF mRNA] CTD PMID:21565208 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
famotidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcyap1 adenylate cyclase activating polypeptide 1 multiple interactions ISO Famotidine inhibits the reaction [ADCYAP1 protein affects the secretion of Acids] CTD PMID:20388963 NCBI chr 9:113,102,632...113,122,500
Ensembl chr 9:113,103,718...113,109,773
JBrowse link
G Agt angiotensinogen multiple interactions EXP Famotidine inhibits the reaction [Indomethacin results in increased expression of AGT protein] CTD PMID:27645307 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Braf B-Raf proto-oncogene, serine/threonine kinase decreases activity ISO Famotidine results in decreased activity of BRAF protein CTD PMID:20823850 NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463
JBrowse link
G Car12 carbonic anhydrase 12 multiple interactions ISO Famotidine binds to and results in decreased activity of CA12 protein CTD PMID:30344913 NCBI chr 8:67,274,739...67,330,428
Ensembl chr 8:67,274,359...67,330,440
JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions ISO Famotidine binds to and results in decreased activity of CA2 protein CTD PMID:30344913 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
JBrowse link
G Car6 carbonic anhydrase 6 multiple interactions ISO Famotidine binds to and results in decreased activity of CA6 protein CTD PMID:30344913 NCBI chr 5:160,658,104...160,676,644
Ensembl chr 5:160,658,105...160,676,644
JBrowse link
G Car7 carbonic anhydrase 7 multiple interactions ISO Famotidine binds to and results in decreased activity of CA7 protein CTD PMID:30344913 NCBI chr19:429,063...438,478
Ensembl chr19:429,075...438,467
JBrowse link
G Cat catalase multiple interactions EXP Famotidine inhibits the reaction [Indomethacin results in decreased activity of CAT protein]; Famotidine inhibits the reaction [Indomethacin results in increased activity of CAT protein]; Quercetin promotes the reaction [Famotidine inhibits the reaction [Indomethacin results in decreased activity of CAT protein]] CTD PMID:18726076 PMID:19034656 PMID:19497431 PMID:25926722 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cd80 Cd80 molecule multiple interactions ISO Famotidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein]] CTD PMID:12538815 NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
increases expression
ISO Famotidine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CTNNB1 mRNA]
Famotidine results in increased expression of CTNNB1 mRNA
CTD PMID:31563592 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 increases expression EXP Famotidine results in increased expression of CXCL1 protein CTD PMID:12023551 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 multiple interactions ISO Famotidine inhibits the reaction [CYP2C19 gene affects the susceptibility to Lansoprazole] CTD PMID:15963082 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO [Famotidine co-treated with Sucralfate] results in increased expression of FGF2 mRNA CTD PMID:17717918 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Fgf21 fibroblast growth factor 21 increases expression ISO Famotidine results in increased expression of FGF21 protein CTD PMID:8774986 NCBI chr 1:96,083,360...96,084,911
Ensembl chr 1:96,083,441...96,090,454
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Famotidine inhibits the reaction [[Dimaprit binds to and results in increased activity of HRH2 protein] which results in increased expression of FOS mRNA]; Famotidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH2 protein] which results in increased expression of FOS mRNA] CTD PMID:9187264 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions EXP Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG1 protein]]; Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein]] CTD PMID:15363660 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
JBrowse link
G Gabra3 gamma-aminobutyric acid type A receptor subunit alpha 3 multiple interactions EXP Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG1 protein]]; Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:15363660 NCBI chr  X:150,244,745...150,501,566
Ensembl chr  X:150,261,607...150,501,559
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions EXP Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG1 protein]]; Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein]]; Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG1 protein]]; Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:15363660 NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251
JBrowse link
G Gabrg1 gamma-aminobutyric acid type A receptor subunit gamma 1 multiple interactions EXP Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG1 protein]]; Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG1 protein]] CTD PMID:15363660 NCBI chr14:37,396,217...37,469,606
Ensembl chr14:37,396,294...37,635,956
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions EXP Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:15363660 NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346
JBrowse link
G Gast gastrin affects expression
increases expression
ISO
EXP
Famotidine affects the expression of GAST protein
Famotidine results in increased expression of GAST protein
CTD PMID:12503773 PMID:17652263 NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496
JBrowse link
G Ghrl ghrelin and obestatin prepropeptide multiple interactions EXP Famotidine inhibits the reaction [GHRL protein results in increased secretion of Acids] CTD PMID:16838121 NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO Famotidine inhibits the reaction [Dizocilpine Maleate results in decreased phosphorylation of and results in increased activity of GSK3B protein]; Famotidine inhibits the reaction [Dizocilpine Maleate results in increased expression of GSK3B mRNA] CTD PMID:31563592 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Hrh2 histamine receptor H 2 multiple interactions
decreases activity
increases expression
ISO
EXP
[Famotidine binds to and results in decreased activity of HRH2 protein] which affects the susceptibility to Metformin; Famotidine binds to and results in decreased activity of HRH2 protein; Famotidine inhibits the reaction [[Dimaprit binds to and results in increased activity of HRH2 protein] which results in increased expression of FOS mRNA]; Famotidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH2 protein] which results in increased expression of FOS mRNA]
Famotidine results in decreased activity of HRH2 protein
[Famotidine binds to and results in decreased activity of HRH2 protein] which affects the susceptibility to Histamine
Famotidine results in increased expression of HRH2 protein
CTD PMID:9187264 PMID:9681472 PMID:12832840 PMID:15961859 PMID:16632449 More... NCBI chr17:10,366,004...10,407,791
Ensembl chr17:10,368,298...10,407,631
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A decreases expression
multiple interactions
EXP Famotidine results in decreased expression of HSPA1A protein
Zinc Compounds analog inhibits the reaction [Famotidine results in decreased expression of HSPA1A protein]; Zinc Sulfate inhibits the reaction [Famotidine results in decreased expression of HSPA1A protein]
CTD PMID:16945336 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]] CTD PMID:11752121 PMID:12364868 PMID:12538815 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifng interferon gamma multiple interactions ISO Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]
Famotidine inhibits the reaction [Dimaprit inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNG protein]]
CTD PMID:11752121 PMID:12364868 PMID:19277450 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]] CTD PMID:11752121 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il12a interleukin 12A multiple interactions ISO Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]] CTD PMID:11752121 PMID:12364868 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
JBrowse link
G Il12b interleukin 12B multiple interactions ISO Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]] CTD PMID:11752121 PMID:12364868 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il18 interleukin 18 multiple interactions ISO Famotidine inhibits the reaction [Cimetidine results in increased expression of IL18 protein]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]] CTD PMID:11752121 PMID:12364868 PMID:16723495 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
[Famotidine co-treated with Sucralfate] results in decreased expression of IL1B mRNA
Famotidine inhibits the reaction [Ethanol results in increased expression of IL1B protein]; Famotidine inhibits the reaction [Indomethacin results in increased expression of IL1B mRNA]
CTD PMID:17717918 PMID:27474069 PMID:27645307 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 multiple interactions ISO Famotidine inhibits the reaction [Dimaprit inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein]] CTD PMID:19277450 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il4 interleukin 4 multiple interactions ISO Famotidine inhibits the reaction [Dimaprit inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL4 protein]] CTD PMID:19277450 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 multiple interactions EXP Famotidine inhibits the reaction [Ethanol results in increased expression of IL6 protein]; Famotidine inhibits the reaction [Ethanol results in increased secretion of IL6 protein] CTD PMID:17603938 PMID:27474069 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Famotidine inhibits the reaction [Histamine results in increased phosphorylation of MAPK1 protein] CTD PMID:17656145 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Famotidine inhibits the reaction [Histamine results in increased phosphorylation of MAPK3 protein] CTD PMID:17656145 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO Famotidine inhibits the reaction [Histamine results in increased expression of MMP1 mRNA]; Famotidine inhibits the reaction [Histamine results in increased secretion of MMP1 protein] CTD PMID:17656145 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP Famotidine inhibits the reaction [Ethanol results in increased expression of and results in increased activity of MMP9 protein]; Famotidine inhibits the reaction [Ethanol results in increased expression of MMP9 mRNA]; Famotidine inhibits the reaction [Ethanol results in increased secretion of and results in increased activity of MMP9 protein]; Famotidine inhibits the reaction [Ethanol results in increased secretion of MMP9 protein] CTD PMID:17603938 PMID:22257724 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpo myeloperoxidase multiple interactions
increases expression
ISO
EXP
Famotidine inhibits the reaction [Acids results in increased activity of MPO protein]
Famotidine results in increased expression of MPO protein
Famotidine inhibits the reaction [Ethanol results in increased activity of MPO protein]; Famotidine inhibits the reaction [Indomethacin results in increased activity of MPO protein]; Famotidine promotes the reaction [Chlorpheniramine results in decreased activity of MPO protein]; Quercetin promotes the reaction [Famotidine inhibits the reaction [Indomethacin results in increased activity of MPO protein]]
CTD PMID:12023551 PMID:16091555 PMID:16437673 PMID:17603938 PMID:18726076 More... NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nppb natriuretic peptide B decreases expression EXP Famotidine results in decreased expression of NPPB protein CTD PMID:30310171 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
JBrowse link
G Ntf3 neurotrophin 3 multiple interactions EXP [Pyrilamine co-treated with Famotidine co-treated with ciproxifan] inhibits the reaction [Histamine results in increased expression of NTF3 protein]; [Pyrilamine co-treated with Famotidine] inhibits the reaction [Histamine results in increased expression of NTF3 protein]; Famotidine inhibits the reaction [Histamine results in increased expression of NTF3 protein] CTD PMID:21276809 NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP [Famotidine co-treated with Indomethacin] promotes the reaction [Acetic Acid results in increased expression of PCNA protein]; Famotidine promotes the reaction [Acetic Acid results in increased expression of PCNA protein] CTD PMID:18853145 PMID:19251492 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Ppp3ca protein phosphatase 3 catalytic subunit alpha decreases expression EXP Famotidine results in decreased expression of PPP3CA protein CTD PMID:30310171 NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974
JBrowse link
G Prdx3 peroxiredoxin 3 increases expression EXP Famotidine results in increased expression of PRDX3 protein CTD PMID:30310171 NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111
JBrowse link
G Prl prolactin increases expression ISO Famotidine results in increased expression of PRL protein CTD PMID:8104296 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions EXP Famotidine inhibits the reaction [Indomethacin results in increased expression of PTGS1 mRNA] CTD PMID:27645307 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Famotidine inhibits the reaction [Indomethacin results in increased expression of PTGS2 mRNA] CTD PMID:27645307 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Famotidine inhibits the reaction [Ethanol results in increased expression of RELA protein] CTD PMID:27474069 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G RT1-A2 RT1 class Ia, locus A2 affects expression ISO Famotidine affects the expression of HLA-E mRNA CTD PMID:25811541 NCBI chr20:4,870,939...4,910,183 JBrowse link
G RT1-DMb RT1 class II, locus DMb affects expression ISO Famotidine affects the expression of HLA-DMB mRNA CTD PMID:25811541 NCBI chr20:4,693,102...4,700,340
Ensembl chr20:4,693,103...4,700,340
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions EXP Heparin promotes the reaction [[Famotidine co-treated with Lipopolysaccharides] results in increased expression of SERPINE1 protein] CTD PMID:16401727 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Slc19a3 solute carrier family 19 member 3 multiple interactions
increases uptake
ISO Famotidine inhibits the reaction [SLC19A3 protein results in increased uptake of Metformin]; Famotidine inhibits the reaction [SLC19A3 protein results in increased uptake of Thiamine]
SLC19A3 protein results in increased uptake of Famotidine
CTD PMID:26528626 NCBI chr 9:84,275,722...84,299,368
Ensembl chr 9:84,277,024...84,299,337
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions
increases uptake
affects transport
ISO
EXP
Famotidine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
SLC22A1 protein results in increased uptake of Famotidine
SLC22A1 protein affects the transport of Famotidine
CTD PMID:16006492 PMID:16141367 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
JBrowse link
G Slc22a2 solute carrier family 22 member 2 increases uptake
multiple interactions
ISO
EXP
SLC22A2 protein results in increased uptake of Famotidine
Famotidine inhibits the reaction [SLC22A2 protein affects the transport of Tetraethylammonium]; Famotidine inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Famotidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD PMID:15496291 PMID:16006492 PMID:16141367 PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions
decreases activity
ISO Famotidine inhibits the reaction [SLC22A3 protein affects the transport of 1-Methyl-4-phenylpyridinium]; Famotidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
Famotidine results in decreased activity of SLC22A3 protein
CTD PMID:16141367 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions
increases uptake
ISO
EXP
estrone sulfate inhibits the reaction [SLC22A8 protein results in increased uptake of Famotidine]; Famotidine inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Probenecid inhibits the reaction [SLC22A8 protein affects the transport of Famotidine]
Famotidine inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; Penicillin G inhibits the reaction [SLC22A8 protein results in increased uptake of Famotidine]; Probenecid inhibits the reaction [SLC22A8 protein affects the transport of Famotidine]; Probenecid promotes the reaction [SLC22A8 protein results in increased uptake of Famotidine]
Famotidine inhibits the reaction [SLC22A8 protein results in increased uptake of p-Aminohippuric Acid]
CTD PMID:15100168 PMID:15319347 PMID:15496291 PMID:16006492 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Famotidine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Famotidine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904
JBrowse link
G Tacr1 tachykinin receptor 1 multiple interactions ISO Famotidine inhibits the reaction [Acids affects the localization of TACR1 protein] CTD PMID:16091555 NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
ISO
EXP
Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]
Famotidine results in increased secretion of TNF protein
Famotidine inhibits the reaction [Dimaprit inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TNF protein]]
Famotidine inhibits the reaction [Ethanol results in increased expression of TNF protein]; Famotidine inhibits the reaction [Ethanol results in increased secretion of TNF protein]; Famotidine inhibits the reaction [Indomethacin results in increased expression of TNF mRNA]
CTD PMID:11752121 PMID:12538815 PMID:17603938 PMID:17698507 PMID:19277450 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
hydrocortisone succinate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [hydrocortisone hemisuccinate co-treated with Dimethyl Sulfoxide] results in increased expression of CYP1A2 CTD PMID:18347083 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [hydrocortisone hemisuccinate co-treated with Dimethyl Sulfoxide] results in increased expression of CYP3A4 CTD PMID:18347083 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G F2 coagulation factor II, thrombin affects expression ISO hydrocortisone hemisuccinate affects the expression of F2 protein CTD PMID:12542493 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
JBrowse link
G Il18 interleukin 18 decreases secretion ISO hydrocortisone hemisuccinate results in decreased secretion of IL18 protein CTD PMID:20421217 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1b interleukin 1 beta decreases secretion ISO hydrocortisone hemisuccinate results in decreased secretion of IL1B protein CTD PMID:20421217 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 decreases secretion ISO hydrocortisone hemisuccinate results in decreased secretion of IL6 protein CTD PMID:20421217 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Tnf tumor necrosis factor decreases secretion ISO hydrocortisone hemisuccinate results in decreased secretion of TNF protein CTD PMID:20421217 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
lansoprazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO Lansoprazole results in increased expression of ABCA1 protein
Lansoprazole results in increased expression of ABCA1 mRNA; Lansoprazole results in increased expression of ABCA1 protein
CTD PMID:20060385 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects response to substance ISO ABCB1 affects the susceptibility to Lansoprazole CTD PMID:19238367 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Apoe apolipoprotein E increases expression ISO Lansoprazole results in increased expression of APOE mRNA; Lansoprazole results in increased expression of APOE protein CTD PMID:20060385 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Aqp4 aquaporin 4 increases expression ISO Lansoprazole results in increased expression of AQP4 mRNA; Lansoprazole results in increased expression of AQP4 protein CTD PMID:20437101 NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Lansoprazole inhibits the reaction [Diatrizoate Meglumine results in decreased expression of BCL2 mRNA] CTD PMID:28412091 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G C1qa complement C1q A chain decreases expression EXP Lansoprazole results in decreased expression of C1QA mRNA CTD PMID:25626140 NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534
JBrowse link
G C1qc complement C1q C chain decreases expression EXP Lansoprazole results in decreased expression of C1QC mRNA CTD PMID:25626140 NCBI chr 5:149,127,412...149,130,757
Ensembl chr 5:149,127,415...149,131,017
JBrowse link
G C4bpa complement component 4 binding protein, alpha decreases expression EXP Lansoprazole results in decreased expression of C4BPA mRNA CTD PMID:25626140 NCBI chr13:42,075,715...42,111,205
Ensembl chr13:42,075,717...42,111,205
JBrowse link
G C4bpb complement component 4 binding protein, beta decreases expression EXP Lansoprazole results in decreased expression of C4BPB mRNA CTD PMID:25626140 NCBI chr13:42,120,798...42,131,515
Ensembl chr13:42,120,798...42,131,817
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
Lansoprazole inhibits the reaction [Demecolcine results in increased activity of CASP3 protein]
Lansoprazole inhibits the reaction [Diatrizoate Meglumine results in increased expression of CASP3 mRNA]; Lansoprazole inhibits the reaction [Ethanol results in increased expression of CASP3 protein]
CTD PMID:12530016 PMID:28412091 PMID:29339218 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase multiple interactions EXP Lansoprazole inhibits the reaction [Ethanol results in decreased activity of CAT protein]; Lansoprazole inhibits the reaction [Indomethacin results in increased activity of CAT protein] CTD PMID:18726076 PMID:29339218 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cfi complement factor I decreases expression EXP Lansoprazole results in decreased expression of CFI mRNA CTD PMID:25626140 NCBI chr 2:218,389,079...218,430,565
Ensembl chr 2:218,387,990...218,430,561
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases expression
multiple interactions
EXP Lansoprazole results in decreased expression of CXCL1 mRNA; Lansoprazole results in decreased expression of CXCL1 protein
Lansoprazole inhibits the reaction [Indomethacin results in increased expression of CXCL1 mRNA]; Lansoprazole inhibits the reaction [Indomethacin results in increased expression of CXCL1 protein]
CTD PMID:15334676 PMID:16328016 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity
decreases activity
increases expression
ISO
EXP
Lansoprazole results in increased activity of CYP1A1 promoter
Lansoprazole results in decreased activity of CYP1A1 protein
Lansoprazole results in increased expression of CYP1A1 mRNA; Lansoprazole results in increased expression of CYP1A1 protein
CTD PMID:8169844 PMID:8647108 PMID:8900397 PMID:9041675 PMID:9152597 More... NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO
EXP
Lansoprazole results in increased expression of CYP1A2 mRNA; Lansoprazole results in increased expression of CYP1A2 protein CTD PMID:8169844 PMID:9152597 PMID:9744552 PMID:12623754 PMID:14550749 More... NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression
decreases activity
ISO Lansoprazole results in increased expression of CYP1B1 mRNA
Lansoprazole results in decreased activity of CYP1B1 protein
CTD PMID:12623754 PMID:33814510 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP Lansoprazole results in increased expression of CYP2B1 protein CTD PMID:9152597 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP Lansoprazole results in increased expression of CYP2B2 protein CTD PMID:9152597 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 increases hydroxylation
multiple interactions
ISO CYP2C9 protein results in increased hydroxylation of Lansoprazole
CYP2C18 protein results in increased hydroxylation of Lansoprazole
Lansoprazole inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Diclofenac]
CTD PMID:7870052 PMID:8627562 PMID:12975331 PMID:15258107 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 affects response to substance
increases expression
decreases activity
increases hydroxylation
affects metabolic processing
increases metabolic processing
decreases metabolic processing
multiple interactions
ISO
EXP
CYP2C19 gene affects the susceptibility to Lansoprazole; CYP2C19 gene polymorphism affects the susceptibility to Lansoprazole
Lansoprazole results in increased expression of CYP2C6V1 mRNA; Lansoprazole results in increased expression of CYP2C6V1 protein
Lansoprazole results in decreased activity of CYP2C19 protein
CYP2C19 protein results in increased hydroxylation of Lansoprazole
CYP2C19 protein affects the metabolism of Lansoprazole
CYP2C19 protein results in increased metabolism of Lansoprazole; Lansoprazole results in increased metabolism of CYP2C19 protein
CYP2C19 gene polymorphism results in decreased metabolism of Lansoprazole
CYP2C19 affects the reaction [Lansoprazole affects the susceptibility to Tacrolimus]; CYP2C19 affects the susceptibility to [Tacrolimus co-treated with Lansoprazole]; CYP2C19 gene mutant form affects the susceptibility to [Lansoprazole co-treated with Tacrolimus]; Famotidine inhibits the reaction [CYP2C19 gene affects the susceptibility to Lansoprazole]; Lansoprazole inhibits the reaction [CYP2C19 protein results in increased hydroxylation of Mephenytoin]
CTD PMID:8627562 PMID:8930576 PMID:9152597 PMID:9272410 PMID:11829200 More... NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 affects metabolic processing
increases hydroxylation
ISO CYP2C8 protein affects the metabolism of Lansoprazole
CYP2C8 protein results in increased hydroxylation of Lansoprazole
CTD PMID:7870052 PMID:8627562
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases degradation
multiple interactions
ISO Lansoprazole results in decreased degradation of CYP2E1 protein
Lansoprazole results in increased expression of and results in increased activity of CYP2E1 protein
CTD PMID:36243147 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing
increases hydroxylation
increases expression
affects metabolic processing
ISO CYP3A4 protein results in increased metabolism of Lansoprazole
CYP3A4 protein results in increased hydroxylation of Lansoprazole
Lansoprazole results in increased expression of CYP3A4 mRNA; Lansoprazole results in increased expression of CYP3A4 protein
CYP3A4 protein affects the metabolism of Lansoprazole
CTD PMID:7870052 PMID:8627562 PMID:8930576 PMID:9744552 PMID:10859152 More... NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions ISO CYP3A5 affects the susceptibility to [Tacrolimus co-treated with Lansoprazole] CTD PMID:17377957 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Cyp4a1 cytochrome P450, family 4, subfamily a, polypeptide 1 increases expression EXP Lansoprazole results in increased expression of CYP4A1 protein CTD PMID:9152597 NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464
JBrowse link
G Egfr epidermal growth factor receptor increases expression ISO Lansoprazole results in increased expression of EGFR protein CTD PMID:9881512 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Fas Fas cell surface death receptor multiple interactions EXP Lansoprazole inhibits the reaction [Ethanol results in increased expression of FAS protein] CTD PMID:29339218 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand multiple interactions EXP Lansoprazole inhibits the reaction [Ethanol results in increased expression of FASLG protein] CTD PMID:29339218 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fgf2 fibroblast growth factor 2 decreases expression ISO Lansoprazole results in decreased expression of FGF2 protein CTD PMID:9881512 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
JBrowse link
G Fgf21 fibroblast growth factor 21 increases expression ISO Lansoprazole results in increased expression of FGF21 protein CTD PMID:8774986 NCBI chr 1:96,083,360...96,084,911
Ensembl chr 1:96,083,441...96,090,454
JBrowse link
G Gast gastrin increases expression ISO
EXP
Lansoprazole results in increased expression of GAST protein CTD PMID:7750667 PMID:8792694 PMID:11680587 PMID:11975934 PMID:12189558 More... NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions ISO Lansoprazole inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] CTD PMID:23769903 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Hamp hepcidin antimicrobial peptide increases expression ISO Lansoprazole results in increased expression of HAMP mRNA CTD PMID:31669099 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
increases activity
ISO
EXP
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lansoprazole results in increased expression of HMOX1 mRNA]; Lansoprazole results in increased activity of and results in increased expression of HMOX1 protein
Lansoprazole inhibits the reaction [Diatrizoate Meglumine results in increased expression of HMOX1 mRNA]; NFE2L2 mRNA affects the reaction [Lansoprazole results in increased expression of HMOX1 mRNA]; NFE2L2 mRNA affects the reaction [Lansoprazole results in increased expression of HMOX1 protein]; U 0126 inhibits the reaction [Lansoprazole results in increased expression of HMOX1 protein]
Lansoprazole results in increased expression of HMOX1 mRNA; Lansoprazole results in increased expression of HMOX1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lansoprazole results in increased activity of HMOX1 promoter]
CTD PMID:16712795 PMID:19628634 PMID:19764090 PMID:28412091 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Ifng interferon gamma multiple interactions
decreases expression
ISO Lansoprazole inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]
Lansoprazole results in decreased expression of IFNG mRNA
CTD PMID:16932910 PMID:19232345 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 multiple interactions EXP Lansoprazole inhibits the reaction [Ethanol results in decreased expression of IL10 protein] CTD PMID:29339218 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1b interleukin 1 beta decreases expression
multiple interactions
ISO
EXP
Lansoprazole results in decreased expression of IL1B mRNA
Lansoprazole inhibits the reaction [Ethanol results in increased expression of IL1B protein]
CTD PMID:16932910 PMID:29339218 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions
ISO
EXP
Lansoprazole results in decreased expression of IL6 mRNA
Lansoprazole inhibits the reaction [Diatrizoate Meglumine results in increased expression of IL6 mRNA]
CTD PMID:16932910 PMID:28412091 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 increases oxidation EXP Lansoprazole results in increased oxidation of KEAP1 protein CTD PMID:19628634 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions
increases expression
EXP Lansoprazole inhibits the reaction [LHB protein results in increased abundance of Testosterone]
Lansoprazole results in increased expression of LHB protein
CTD PMID:7589908 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation EXP Lansoprazole results in increased phosphorylation of MAPK1 protein CTD PMID:19628634 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation EXP Lansoprazole results in increased phosphorylation of MAPK3 protein CTD PMID:19628634 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapt microtubule-associated protein tau affects binding ISO Lansoprazole binds to MAPT protein alternative form CTD PMID:20110603 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Lansoprazole inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MPO protein]; Lansoprazole inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:17151854 PMID:17895592 PMID:18726076 PMID:24337826 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases expression
increases phosphorylation
EXP Lansoprazole inhibits the reaction [Diatrizoate Meglumine results in increased expression of NFE2L2 mRNA]; NFE2L2 mRNA affects the reaction [Lansoprazole results in increased expression of HMOX1 mRNA]; NFE2L2 mRNA affects the reaction [Lansoprazole results in increased expression of HMOX1 protein]
Lansoprazole results in increased expression of NFE2L2 mRNA
Lansoprazole results in increased phosphorylation of NFE2L2 protein
CTD PMID:19628634 PMID:28412091 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP Lansoprazole inhibits the reaction [Ethanol results in decreased expression of and results in increased phosphorylation of NFKBIA protein] CTD PMID:29339218 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 increases activity ISO Lansoprazole results in increased activity of NR1H2 protein CTD PMID:20060385 NCBI chr 1:95,041,967...95,047,358
Ensembl chr 1:95,041,967...95,047,377
JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases activity ISO Lansoprazole results in increased activity of NR1H3 protein CTD PMID:20060385 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO Lansoprazole results in increased activity of NR1I2 protein CTD PMID:25455453 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Phospho1 phosphoethanolamine/phosphocholine phosphatase 1 decreases activity ISO Lansoprazole results in decreased activity of PHOSPHO1 protein CTD PMID:17227223 NCBI chr10:80,762,062...80,769,596
Ensembl chr10:80,760,792...80,770,342
JBrowse link
G Pomc proopiomelanocortin increases expression ISO Lansoprazole results in increased expression of POMC protein CTD PMID:16524691 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
EXP AG-041R inhibits the reaction [Lansoprazole results in increased expression of PTGS2 protein] CTD PMID:12438555 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Lansoprazole inhibits the reaction [Ethanol results in decreased expression of and results in increased phosphorylation of RELA protein] CTD PMID:29339218 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Retsat retinol saturase decreases expression EXP Lansoprazole results in decreased expression of RETSAT mRNA CTD PMID:25626140 NCBI chr 4:104,653,306...104,662,069
Ensembl chr 4:104,653,155...104,668,310
JBrowse link
G Serping1 serpin family G member 1 decreases expression EXP Lansoprazole results in decreased expression of SERPING1 mRNA CTD PMID:25626140 NCBI chr 3:69,842,726...69,852,583
Ensembl chr 3:69,842,739...69,852,034
JBrowse link
G Shh sonic hedgehog signaling molecule decreases expression ISO Lansoprazole results in decreased expression of SHH mRNA CTD PMID:20437101 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Lansoprazole inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions ISO [Lansoprazole results in decreased activity of SLC22A8 protein] which results in decreased uptake of Indican CTD PMID:36243147 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
JBrowse link
G Tgfa transforming growth factor alpha increases expression ISO Lansoprazole results in increased expression of TGFA protein CTD PMID:9881512 NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO Lansoprazole results in increased expression of TGFB1 protein CTD PMID:36243147 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO
EXP
Lansoprazole inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]
Lansoprazole inhibits the reaction [Ethanol results in increased expression of TNF protein]
Lansoprazole results in decreased expression of TNF mRNA
CTD PMID:16932910 PMID:19232345 PMID:29339218 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP Lansoprazole inhibits the reaction [Diatrizoate Meglumine results in increased expression of TP53 mRNA] CTD PMID:28412091 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression EXP Lansoprazole results in increased expression of UGT1A1 mRNA CTD PMID:25626140 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 increases expression EXP Lansoprazole results in increased expression of UGT2B1 mRNA CTD PMID:25626140 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
JBrowse link
malathion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acbd5 acyl-CoA binding domain containing 5 increases expression ISO Malathion results in increased expression of ACBD5 mRNA CTD PMID:37047231 NCBI chr17:85,206,178...85,248,909
Ensembl chr17:85,206,303...85,248,215
JBrowse link
G Ache acetylcholinesterase multiple interactions
decreases activity
ISO
EXP
[Malathion co-treated with Dichlorvos] results in decreased activity of ACHE protein; Obidoxime Chloride inhibits the reaction [Malathion results in decreased activity of ACHE protein]; Oximes analog inhibits the reaction [Malathion results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Malathion results in decreased activity of ACHE protein]
[Endosulfan co-treated with Malathion] results in decreased activity of ACHE protein; [Malathion co-treated with Permethrin] results in decreased activity of ACHE protein; [Malathion co-treated with Permethrin] results in increased activity of ACHE protein; Taurine inhibits the reaction [Malathion results in decreased activity of ACHE protein]; zinc chloride inhibits the reaction [Malathion results in decreased activity of ACHE protein]
CTD PMID:2380476 PMID:4859365 PMID:14713564 PMID:18617161 PMID:19429256 More... NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Acot6 acyl-CoA thioesterase 6 decreases expression ISO Malathion results in decreased expression of ACOT6 mRNA CTD PMID:37047231 NCBI chr 6:103,732,372...103,741,446
Ensembl chr 6:103,732,372...103,741,446
JBrowse link
G Acsm1 acyl-CoA synthetase medium-chain family member 1 decreases expression ISO Malathion results in decreased expression of ACSM1 mRNA CTD PMID:17311802 NCBI chr 1:173,985,715...174,020,565
Ensembl chr 1:173,984,672...174,025,495
JBrowse link
G Adam11 ADAM metallopeptidase domain 11 increases methylation ISO Malathion results in increased methylation of ADAM11 promoter CTD PMID:37047231 NCBI chr10:87,724,115...87,742,773
Ensembl chr10:87,724,234...87,741,562
JBrowse link
G Adam32 ADAM metallopeptidase domain 32 decreases expression ISO Malathion results in decreased expression of ADAM32 mRNA CTD PMID:37047231 NCBI chr16:67,102,384...67,212,163
Ensembl chr16:67,102,320...67,212,161
JBrowse link
G Adamts12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 decreases expression ISO Malathion results in decreased expression of ADAMTS12 mRNA CTD PMID:37047231 NCBI chr 2:60,032,873...60,327,629
Ensembl chr 2:60,032,873...60,327,629
JBrowse link
G Adamts20 ADAM metallopeptidase with thrombospondin type 1 motif, 20 decreases expression ISO Malathion results in decreased expression of ADAMTS20 mRNA CTD PMID:37047231 NCBI chr 7:125,396,227...125,528,020
Ensembl chr 7:125,397,734...125,527,777
JBrowse link
G Adamts6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 increases expression ISO Malathion results in increased expression of ADAMTS6 mRNA CTD PMID:37047231 NCBI chr 2:35,421,483...35,633,305
Ensembl chr 2:35,421,510...35,633,298
JBrowse link
G Add3 adducin 3 increases expression EXP Malathion results in increased expression of ADD3 mRNA CTD PMID:19784758 NCBI chr 1:252,147,341...252,255,126
Ensembl chr 1:252,147,386...252,255,124
JBrowse link
G Adm adrenomedullin increases expression ISO Malathion results in increased expression of ADM mRNA CTD PMID:37047231 NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654
JBrowse link
G Adra2a adrenoceptor alpha 2A increases expression ISO Malathion results in increased expression of ADRA2A mRNA CTD PMID:37047231 NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365
JBrowse link
G Aff1 ALF transcription elongation factor 1 increases expression ISO Malathion results in increased expression of AFF1 mRNA mutant form CTD PMID:28624474 NCBI chr14:5,861,188...6,024,196
Ensembl chr14:5,863,961...6,024,729
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO [prothioconazole co-treated with terbutylazine co-treated with bitertanol co-treated with cypermethrin co-treated with Malathion] results in increased activity of AHR protein CTD PMID:25684042 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 increases expression ISO Malathion results in increased expression of AKR1C1 mRNA CTD PMID:16079077 PMID:18214805 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 increases expression ISO Malathion results in increased expression of AKR1C2 mRNA CTD PMID:16079077 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
JBrowse link
G Akr1e2 aldo-keto reductase family 1, member E2 decreases expression ISO Malathion results in decreased expression of AKR1E2 mRNA CTD PMID:37047231 NCBI chr17:65,735,909...65,750,441
Ensembl chr17:65,735,943...65,750,441
JBrowse link
G Alkal2 ALK and LTK ligand 2 increases expression ISO Malathion results in increased expression of ALKAL2 mRNA CTD PMID:37047231 NCBI chr 6:47,495,645...47,505,235
Ensembl chr 6:47,495,782...47,505,234
JBrowse link
G Amot angiomotin decreases expression ISO Malathion results in decreased expression of AMOT mRNA CTD PMID:37047231 NCBI chr  X:108,982,399...109,041,265
Ensembl chr  X:108,984,022...109,041,272
JBrowse link
G Angptl2 angiopoietin-like 2 decreases expression ISO Malathion results in decreased expression of ANGPTL2 mRNA CTD PMID:37047231 NCBI chr 3:16,517,185...16,547,024
Ensembl chr 3:16,517,420...16,548,178
JBrowse link
G Angptl4 angiopoietin-like 4 decreases methylation
increases expression
ISO Malathion results in decreased methylation of ANGPTL4 promoter
Malathion results in increased expression of ANGPTL4 mRNA
CTD PMID:37047231 NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519
JBrowse link
G Ank1 ankyrin 1 decreases expression ISO Malathion results in decreased expression of ANK1 mRNA CTD PMID:37047231 NCBI chr16:68,876,294...69,054,963
Ensembl chr16:68,877,504...69,054,759
JBrowse link
G Ankrd55 ankyrin repeat domain 55 increases expression ISO Malathion results in increased expression of ANKRD55 mRNA CTD PMID:37047231 NCBI chr 2:43,883,877...43,983,820
Ensembl chr 2:43,883,857...43,983,680
JBrowse link
G Aplf aprataxin and PNKP like factor decreases expression ISO Malathion results in decreased expression of APLF mRNA CTD PMID:37047231 NCBI chr 4:120,070,471...120,122,656
Ensembl chr 4:120,070,471...120,122,633
JBrowse link
G Aqp12a aquaporin 12A decreases expression ISO Malathion results in decreased expression of AQP12A mRNA CTD PMID:37047231 NCBI chr 9:93,554,527...93,560,011
Ensembl chr 9:93,554,527...93,560,011
JBrowse link
G Aqp9 aquaporin 9 increases expression ISO Malathion results in increased expression of AQP9 mRNA CTD PMID:37047231 NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395
JBrowse link
G Ar androgen receptor multiple interactions
decreases expression
ISO
EXP
[terbutylazine co-treated with bitertanol co-treated with propiconazole co-treated with cypermethrin co-treated with Malathion] inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; [terbutylazine co-treated with bitertanol co-treated with propiconazole co-treated with cypermethrin co-treated with Malathion] results in decreased activity of AR protein
Malathion results in decreased expression of AR mRNA
CTD PMID:23871939 PMID:36336997 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Armc3 armadillo repeat containing 3 decreases expression ISO Malathion results in decreased expression of ARMC3 mRNA CTD PMID:37047231 NCBI chr17:81,814,087...81,917,534
Ensembl chr17:81,832,518...81,917,531
JBrowse link
G Arnt2 aryl hydrocarbon receptor nuclear translocator 2 decreases expression ISO Malathion results in decreased expression of ARNT2 mRNA CTD PMID:37047231 NCBI chr 1:138,236,235...138,392,868
Ensembl chr 1:138,189,940...138,393,153
JBrowse link
G Asic5 acid sensing ion channel subunit family member 5 increases expression ISO Malathion results in increased expression of ASIC5 mRNA CTD PMID:37047231 NCBI chr 2:167,307,984...167,336,812
Ensembl chr 2:167,307,984...167,336,812
JBrowse link
G Atp2b3 ATPase plasma membrane Ca2+ transporting 3 decreases expression ISO Malathion results in decreased expression of ATP2B3 mRNA CTD PMID:37047231 NCBI chr  X:151,216,483...151,289,069
Ensembl chr  X:151,216,507...151,286,775
JBrowse link
G B4galt1 beta-1,4-galactosyltransferase 1 decreases expression ISO Malathion results in decreased expression of B4GALT1 mRNA CTD PMID:32069766 NCBI chr 5:55,935,614...55,982,461
Ensembl chr 5:55,935,615...55,982,461
JBrowse link
G B9d1 B9 domain containing 1 decreases expression ISO Malathion results in decreased expression of B9D1 mRNA CTD PMID:37047231 NCBI chr10:46,186,222...46,196,309
Ensembl chr10:46,186,691...46,196,008
JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
increases expression
multiple interactions
EXP
ISO
Malathion results in decreased expression of BAX mRNA
Malathion results in increased expression of BAX protein
crocin inhibits the reaction [Malathion results in increased expression of BAX protein]
Plant Extracts inhibits the reaction [Malathion results in increased expression of BAX protein]; Polyphenols inhibits the reaction [Malathion results in increased expression of BAX protein]
Acetylcysteine inhibits the reaction [Malathion results in increased expression of BAX protein]
CTD PMID:23774768 PMID:30769050 PMID:32120800 PMID:35274200 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bche butyrylcholinesterase multiple interactions
increases activity
decreases activity
ISO
EXP
Obidoxime Chloride inhibits the reaction [Malathion results in decreased activity of BCHE protein]
Malathion results in increased activity of BCHE protein
CTD PMID:17364237 PMID:18617161 PMID:21983245 PMID:25180440 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
increases expression
multiple interactions
EXP
ISO
Malathion results in decreased expression of BCL2 mRNA
Malathion results in increased expression of BCL2 mRNA
Malathion results in increased expression of BCL2 protein
Acetylcysteine inhibits the reaction [Malathion results in decreased expression of BCL2 protein]
CTD PMID:23774768 PMID:30673264 PMID:30769050 PMID:32120800 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bdnf brain-derived neurotrophic factor decreases secretion
increases methylation
ISO Malathion results in decreased secretion of BDNF protein
Malathion results in increased methylation of BDNF protein
CTD PMID:35292247 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Bmi1 BMI1 proto-oncogene, polycomb ring finger increases expression ISO Malathion results in increased expression of BMI1 mRNA CTD PMID:32069766 NCBI chr17:81,332,175...81,341,625
Ensembl chr17:81,332,214...81,388,690
JBrowse link
G Brd7 bromodomain containing 7 increases expression ISO Malathion results in increased expression of BRD7 mRNA CTD PMID:18214912 NCBI chr19:18,708,792...18,737,497
Ensembl chr19:18,709,022...18,737,494
JBrowse link
G Bsnd barttin CLCNK type accessory subunit beta increases expression ISO Malathion results in increased expression of BSND mRNA CTD PMID:37047231 NCBI chr 5:121,251,774...121,260,571
Ensembl chr 5:121,251,774...121,260,571
JBrowse link
G Btg1 BTG anti-proliferation factor 1 decreases expression ISO Malathion results in decreased expression of BTG1 mRNA CTD PMID:32069766 NCBI chr 7:31,341,391...31,343,649
Ensembl chr 7:31,341,027...31,343,649
JBrowse link
G Bub1 BUB1 mitotic checkpoint serine/threonine kinase decreases expression ISO Malathion results in decreased expression of BUB1 mRNA CTD PMID:16079077 NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650
JBrowse link
G C16h10orf53 similar to human chromosome 10 open reading frame 53 decreases expression ISO Malathion results in decreased expression of C10ORF53 mRNA CTD PMID:37047231 NCBI chr16:7,634,207...7,644,876
Ensembl chr16:7,634,207...7,644,876
JBrowse link
G C1ql2 complement C1q like 2 decreases expression ISO Malathion results in decreased expression of C1QL2 mRNA CTD PMID:37047231 NCBI chr13:31,471,150...31,472,685
Ensembl chr13:31,471,150...31,472,689
JBrowse link
G C2h3orf80 similar to human chromosome 3 open reading frame 80 decreases expression ISO Malathion results in decreased expression of C3ORF80 mRNA CTD PMID:37047231 NCBI chr 2:153,125,312...153,128,124
Ensembl chr 2:153,125,676...153,126,419
JBrowse link
G C3h11orf96 similar to human chromosome 11 open reading frame 96 increases expression ISO Malathion results in increased expression of C11ORF96 mRNA CTD PMID:37047231 NCBI chr 3:79,920,125...79,921,368
Ensembl chr 3:79,920,129...79,921,523
JBrowse link
G C3h15orf48 similar to human chromosome 15 open reading frame 48 increases expression ISO Malathion results in increased expression of C15ORF48 mRNA CTD PMID:37047231 NCBI chr 3:109,719,952...109,723,505
Ensembl chr 3:109,719,897...109,724,006
Ensembl chr 3:109,719,897...109,724,006
JBrowse link
G C5h8orf34 similar to human chromosome 8 open reading frame 34 decreases expression ISO Malathion results in decreased expression of C8ORF34 mRNA CTD PMID:37047231 NCBI chr 5:7,237,968...7,777,119
Ensembl chr 5:7,238,853...7,776,769
JBrowse link
G C7h12orf54 similar to human chromosome 12 open reading frame 54 decreases expression ISO Malathion results in decreased expression of C12ORF54 mRNA CTD PMID:37047231 NCBI chr 7:129,529,811...129,548,676 JBrowse link
G Cabp7 calcium binding protein 7 decreases expression ISO Malathion results in decreased expression of CABP7 mRNA CTD PMID:37047231 NCBI chr14:79,598,822...79,609,172
Ensembl chr14:79,598,827...79,609,240
JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C increases expression ISO Malathion results in increased expression of CACNA1C mRNA CTD PMID:37047231 NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648
JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha multiple interactions EXP Malathion promotes the reaction [NGF protein results in increased expression of CAMK2A mRNA] CTD PMID:28385489 NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
JBrowse link
G Camk2b calcium/calmodulin-dependent protein kinase II beta multiple interactions EXP Malathion promotes the reaction [NGF protein results in increased expression of CAMK2B mRNA] CTD PMID:28385489 NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994
JBrowse link
G Capn8 calpain 8 decreases expression ISO Malathion results in decreased expression of CAPN8 mRNA CTD PMID:37047231 NCBI chr13:94,252,218...94,316,146
Ensembl chr13:94,253,054...94,316,146
JBrowse link
G Cartpt CART prepropeptide increases expression ISO Malathion results in increased expression of CARTPT mRNA CTD PMID:37047231 NCBI chr 2:31,255,098...31,257,452
Ensembl chr 2:31,255,098...31,290,713
JBrowse link
G Casp3 caspase 3 increases activity
increases cleavage
multiple interactions
increases expression
ISO
EXP
Malathion results in increased activity of CASP3 protein
Malathion results in increased cleavage of CASP3 protein
Malathion results in increased activity of and results in increased cleavage of CASP3 protein; Metoclopramide inhibits the reaction [Malathion results in increased activity of and results in increased cleavage of CASP3 protein]
Acetylcysteine inhibits the reaction [Malathion results in increased cleavage of CASP3 protein]
Malathion results in increased expression of CASP3 mRNA
[Vitamin E co-treated with Selenium] inhibits the reaction [Malathion results in increased expression of CASP3 mRNA]; crocin inhibits the reaction [Malathion results in increased cleavage of CASP3 protein]; Levodopa inhibits the reaction [Malathion results in increased cleavage of CASP3 protein]
CTD PMID:12505448 PMID:19815060 PMID:21628957 PMID:27941166 PMID:29027213 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp4 caspase 4 decreases expression ISO Malathion results in decreased expression of CASP4 mRNA CTD PMID:32069766 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
JBrowse link
G Casp8 caspase 8 increases activity ISO Malathion results in increased activity of CASP8 protein CTD PMID:12505448 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity
increases cleavage
multiple interactions
increases expression
ISO
EXP
Malathion results in increased activity of CASP9 protein
Malathion results in increased cleavage of CASP9 protein
Acetylcysteine inhibits the reaction [Malathion results in increased cleavage of CASP9 protein]
[Vitamin E co-treated with Selenium] inhibits the reaction [Malathion results in increased expression of CASP9 mRNA]; crocin inhibits the reaction [Malathion results in increased cleavage of CASP9 protein]; Levodopa inhibits the reaction [Malathion results in increased cleavage of CASP9 protein]
CTD PMID:12505448 PMID:21628957 PMID:27941166 PMID:30769050 PMID:35274200 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions
decreases expression
decreases activity
increases activity
EXP
ISO
[Dimethoate co-treated with Malathion] results in increased activity of CAT protein; [Selenium co-treated with Vitamin E] inhibits the reaction [Malathion results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Malathion results in increased activity of CAT protein]; alpha-Tocopherol inhibits the reaction [Malathion results in increased activity of CAT protein]; Pentoxifylline inhibits the reaction [Malathion results in increased activity of CAT protein]; Taurine inhibits the reaction [Malathion results in decreased activity of CAT protein]; Vitamin E inhibits the reaction [Malathion results in increased activity of CAT protein]; zinc chloride inhibits the reaction [Malathion results in decreased activity of CAT protein]
Malathion results in decreased expression of CAT protein
[Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Malathion results in increased activity of CAT protein]; Acetylcysteine inhibits the reaction [Malathion results in decreased activity of CAT protein]; Ascorbic Acid inhibits the reaction [Malathion results in increased activity of CAT protein]; Vitamin E inhibits the reaction [Malathion results in increased activity of CAT protein]
[Malathion co-treated with 1,4-bis(4-hydroxyiminomethylpyridinium)butane dibromide] results in increased activity of CAT protein; [Malathion co-treated with pralidoxime] results in increased activity of CAT protein; lavender oil inhibits the reaction [Malathion results in decreased expression of CAT protein]; Plant Extracts inhibits the reaction [Malathion results in decreased activity of CAT protein]; Polyphenols inhibits the reaction [Malathion results in decreased activity of CAT protein]
CTD PMID:11834209 PMID:18655177 PMID:19429256 PMID:20194575 PMID:21628957 More... NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cbfb core-binding factor subunit beta increases expression ISO Malathion results in increased expression of CBFB mRNA CTD PMID:32069766 NCBI chr19:33,049,162...33,092,752
Ensembl chr19:33,049,172...33,092,751
JBrowse link
G Ccdc126 coiled-coil domain containing 126 increases expression ISO Malathion results in increased expression of CCDC126 mRNA CTD PMID:37047231 NCBI chr 4:78,297,625...78,318,655
Ensembl chr 4:78,297,551...78,318,655
JBrowse link
G Cck cholecystokinin increases expression EXP Malathion results in increased expression of CCK mRNA CTD PMID:19784758 NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084
JBrowse link
G Ccl1 C-C motif chemokine ligand 1 increases expression ISO Malathion results in increased expression of CCL1 mRNA CTD PMID:37047231 NCBI chr10:67,128,331...67,131,109
Ensembl chr10:67,128,331...67,131,159
JBrowse link
G Ccl19 C-C motif chemokine ligand 19 increases expression ISO Malathion results in increased expression of CCL19 mRNA CTD PMID:37047231 NCBI chr 5:56,963,364...56,965,308
Ensembl chr 5:56,963,364...56,965,308
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression ISO Malathion results in increased expression of CCL20 mRNA CTD PMID:37047231 NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO Malathion results in increased expression of CCL3 mRNA CTD PMID:37047231 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 increases expression ISO Malathion results in increased expression of CCL7 mRNA CTD PMID:37047231 NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
JBrowse link
G Ccm2l CCM2 like scaffold protein increases expression ISO Malathion results in increased expression of CCM2L mRNA CTD PMID:37047231 NCBI chr 3:141,533,470...141,549,136
Ensembl chr 3:141,533,511...141,549,140
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO Malathion results in decreased expression of CCNA2 protein CTD PMID:30769050 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Malathion results in decreased expression of CCNB1 protein CTD PMID:30769050 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccne1 cyclin E1 decreases expression ISO Malathion results in decreased expression of CCNE1 protein CTD PMID:30769050 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Ccser1 coiled-coil serine-rich protein 1 increases expression ISO Malathion results in increased expression of CCSER1 mRNA CTD PMID:37047231 NCBI chr 4:90,153,873...91,391,441
Ensembl chr 4:90,292,780...91,388,786
JBrowse link
G Cd14 CD14 molecule decreases expression ISO Malathion results in decreased expression of CD14 mRNA CTD PMID:32069766 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
JBrowse link
G Cd274 CD274 molecule increases expression ISO Malathion results in increased expression of CD274 mRNA CTD PMID:37047231 NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450
JBrowse link
G Cd36 CD36 molecule increases expression ISO Malathion results in increased expression of CD36 mRNA CTD PMID:32069766 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
JBrowse link
G Cd5 Cd5 molecule decreases expression ISO Malathion results in decreased expression of CD5 mRNA CTD PMID:32069766 NCBI chr 1:207,365,337...207,386,313
Ensembl chr 1:207,365,337...207,386,313
JBrowse link
G Cd69 Cd69 molecule increases expression ISO Malathion results in increased expression of CD69 mRNA CTD PMID:37047231 NCBI chr 4:162,725,446...162,733,364
Ensembl chr 4:162,725,446...162,733,542
JBrowse link
G Cdc20 cell division cycle 20 decreases expression ISO Malathion results in decreased expression of CDC20 mRNA CTD PMID:18214805 NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512
JBrowse link
G Cdk15 cyclin-dependent kinase 15 increases expression ISO Malathion results in increased expression of CDK15 mRNA CTD PMID:37047231 NCBI chr 9:60,710,787...60,803,638
Ensembl chr 9:60,711,715...60,802,777
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression
increases expression
ISO Malathion results in decreased expression of CDK2 protein
Malathion results in increased expression of CDK2 mRNA
CTD PMID:30769050 PMID:32069766 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cebpg CCAAT/enhancer binding protein gamma increases expression ISO Malathion results in increased expression of CEBPG mRNA CTD PMID:32069766 NCBI chr 1:87,683,060...87,692,772
Ensembl chr 1:87,684,019...87,694,569
JBrowse link
G Cenpf centromere protein F decreases expression ISO Malathion results in decreased expression of CENPF mRNA CTD PMID:16079077 NCBI chr13:101,184,127...101,229,714
Ensembl chr13:101,184,127...101,229,669
JBrowse link
G Ces1d carboxylesterase 1D increases expression ISO Malathion results in increased expression of CES1 mRNA CTD PMID:17311802 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
JBrowse link
G Cfap157 cilia and flagella associated protein 157 decreases expression ISO Malathion results in decreased expression of CFAP157 mRNA CTD PMID:37047231 NCBI chr 3:16,066,521...16,073,504
Ensembl chr 3:16,066,521...16,073,495
JBrowse link
G Cfap91 cilia and flagella associated protein 91 decreases expression ISO Malathion results in decreased expression of CFAP91 mRNA CTD PMID:37047231 NCBI chr11:62,413,613...62,457,281
Ensembl chr11:62,413,602...62,457,293
JBrowse link
G Cfb complement factor B increases expression ISO Malathion results in increased expression of CFB mRNA CTD PMID:37047231 NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505
JBrowse link
G Ch25h cholesterol 25-hydroxylase increases expression ISO Malathion results in increased expression of CH25H mRNA CTD PMID:37047231 NCBI chr 1:232,014,877...232,016,195
Ensembl chr 1:232,014,880...232,016,195
JBrowse link
G Cldn12 claudin 12 increases expression ISO Malathion results in increased expression of CLDN12 mRNA CTD PMID:37047231 NCBI chr 4:28,522,659...28,533,647
Ensembl chr 4:28,522,678...28,533,801
JBrowse link
G Cldn22 claudin 22 decreases expression ISO Malathion results in decreased expression of CLDN22 mRNA CTD PMID:37047231 NCBI chr16:44,422,344...44,423,370
Ensembl chr16:44,422,345...44,423,354
JBrowse link
G Cldn5 claudin 5 multiple interactions
decreases expression
EXP [Malathion co-treated with Lead] results in decreased expression of CLDN5 protein
Malathion results in decreased expression of CLDN5 protein
CTD PMID:20970449 NCBI chr11:82,212,822...82,214,248
Ensembl chr11:82,211,475...82,214,992
JBrowse link
G Cma1 chymase 1 decreases expression ISO Malathion results in decreased expression of CMA1 mRNA CTD PMID:37047231 NCBI chr15:29,417,451...29,420,233
Ensembl chr15:29,417,451...29,420,233
JBrowse link
G Cntn4 contactin 4 increases expression ISO Malathion results in increased expression of CNTN4 mRNA CTD PMID:37047231 NCBI chr 4:138,624,584...139,622,499
Ensembl chr 4:139,099,152...139,621,090
JBrowse link
G Col1a2 collagen type I alpha 2 chain increases expression ISO Malathion results in increased expression of COL1A2 mRNA CTD PMID:32069766 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
JBrowse link
G Cpne9 copine family member 9 decreases expression ISO Malathion results in decreased expression of CPNE9 mRNA CTD PMID:37047231 NCBI chr 4:146,429,961...146,454,335
Ensembl chr 4:146,430,792...146,454,333
JBrowse link
G Cpz carboxypeptidase Z decreases expression ISO Malathion results in decreased expression of CPZ mRNA CTD PMID:37047231 NCBI chr14:75,223,692...75,246,946
Ensembl chr14:75,223,605...75,246,945
JBrowse link
G Crh corticotropin releasing hormone multiple interactions
decreases expression
EXP caffeic acid inhibits the reaction [Malathion results in decreased expression of CRH mRNA] CTD PMID:20233601 PMID:25404496 NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
JBrowse link
G Crisp3 cysteine-rich secretory protein 3 decreases expression ISO Malathion results in decreased expression of CRISP3 mRNA CTD PMID:37047231 NCBI chr 9:20,432,051...20,472,663
Ensembl chr 9:20,450,908...20,472,658
JBrowse link
G Crispld2 cysteine-rich secretory protein LCCL domain containing 2 decreases expression EXP Malathion results in decreased expression of CRISPLD2 mRNA CTD PMID:19784758 NCBI chr19:48,053,153...48,111,485
Ensembl chr19:48,053,287...48,110,465
JBrowse link
G Csf2 colony stimulating factor 2 increases expression EXP
ISO
Malathion results in increased expression of CSF2 protein
Malathion results in increased expression of CSF2 mRNA
CTD PMID:34778934 PMID:37047231 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Csf3 colony stimulating factor 3 increases expression ISO Malathion results in increased expression of CSF3 mRNA CTD PMID:37047231 NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603
JBrowse link
G Ctsd cathepsin D increases expression ISO Malathion results in increased expression of CTSD protein CTD PMID:8812242 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
JBrowse link
G Cxcl11 C-X-C motif chemokine ligand 11 increases expression ISO Malathion results in increased expression of CXCL11 mRNA CTD PMID:37047231 NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,689,424...15,692,271
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions
increases expression
ISO Plant Extracts inhibits the reaction [Malathion results in increased expression of CYBB protein]; Polyphenols inhibits the reaction [Malathion results in increased expression of CYBB protein] CTD PMID:32120800 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:13,359,430...13,392,586
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression
multiple interactions
ISO Malathion results in decreased expression of CYP11A1 mRNA
lavender oil inhibits the reaction [Malathion results in decreased expression of CYP11A1 mRNA]
CTD PMID:30409133 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions EXP [bitertanol co-treated with propiconazole co-treated with cypermethrin co-treated with Malathion co-treated with terbutylazine] results in increased expression of CYP19A1 mRNA CTD PMID:23954766 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects metabolic processing
increases expression
ISO CYP1A2 protein affects the metabolism of Malathion
Malathion results in increased expression of CYP1A2 mRNA
CTD PMID:15557345 PMID:22310298 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 increases expression ISO Malathion results in increased expression of CYP27B1 mRNA CTD PMID:37047231 NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 affects metabolic processing
multiple interactions
increases expression
decreases activity
ISO CYP2B6 protein affects the metabolism of Malathion
Malathion promotes the reaction [isomalathion results in increased expression of CYP2B6 mRNA]
Malathion results in increased expression of CYP2B6 mRNA
Malathion results in decreased activity of CYP2B6 protein
CTD PMID:15557345 PMID:22310298 PMID:24333466 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases activity
multiple interactions
ISO Malathion results in decreased activity of CYP2C9 protein
Malathion inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]
CTD PMID:20183062 PMID:22634058 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases activity
ISO Malathion inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone]
Malathion results in decreased activity of CYP2E1 protein
CTD PMID:22634058 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases expression
affects metabolic processing
ISO [Malathion co-treated with isomalathion] results in increased expression of CYP3A4 mRNA
Malathion results in increased expression of CYP3A4 mRNA
CYP3A4 protein affects the metabolism of Malathion
CTD PMID:15557345 PMID:17110060 PMID:22310298 PMID:24333466 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects metabolic processing
increases expression
ISO CYP3A5 protein affects the metabolism of Malathion
Malathion results in increased expression of CYP3A5 mRNA
CTD PMID:17110060 PMID:37047231 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 multiple interactions ISO [Insecticides results in increased abundance of Malathion] which affects the methylation of CYP8B1 gene CTD PMID:34516295 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
JBrowse link
G Dcn decorin increases expression ISO Malathion results in increased expression of DCN mRNA CTD PMID:37047231 NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270
JBrowse link
G Ddc dopa decarboxylase affects binding
increases expression
ISO Malathion binds to [DDC protein binds to Pyridoxal Phosphate]; Malathion binds to DDC protein
Malathion results in increased expression of DDC mRNA
CTD PMID:35151785 PMID:37047231 NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208
JBrowse link
G Ddr1 discoidin domain receptor tyrosine kinase 1 decreases expression ISO Malathion results in decreased expression of DDR1 mRNA CTD PMID:37047231 NCBI chr20:3,042,494...3,064,442
Ensembl chr20:3,044,320...3,064,468
JBrowse link
G Ddx11 DEAD/H-box helicase 11 increases expression ISO Malathion results in increased expression of DDX11 mRNA CTD PMID:32069766 NCBI chr 9:105,833,234...105,862,844
Ensembl chr 9:105,833,504...105,862,550
JBrowse link
G Dio1 iodothyronine deiodinase 1 decreases expression ISO Malathion results in decreased expression of DIO1 mRNA CTD PMID:37047231 NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970
JBrowse link
G Disc1 DISC1 scaffold protein increases expression ISO Malathion results in increased expression of DISC1 mRNA CTD PMID:37047231 NCBI chr19:53,014,201...53,223,617
Ensembl chr19:53,014,616...53,219,778
JBrowse link
G Dkk2 dickkopf WNT signaling pathway inhibitor 2 increases expression ISO Malathion results in increased expression of DKK2 mRNA CTD PMID:37047231 NCBI chr 2:220,568,338...220,660,225
Ensembl chr 2:220,568,338...220,660,225
JBrowse link
G Dlg2 discs large MAGUK scaffold protein 2 increases expression ISO Malathion results in increased expression of DLG2 mRNA CTD PMID:37047231 NCBI chr 1:144,451,653...146,503,949
Ensembl chr 1:144,451,472...146,499,475
JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases expression EXP Malathion results in decreased expression of DNMT1 mRNA CTD PMID:36370973 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha affects expression EXP Malathion affects the expression of DNMT3A mRNA CTD PMID:36370973 NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687
JBrowse link
G Dnmt3b DNA methyltransferase 3 beta affects expression EXP Malathion affects the expression of DNMT3B mRNA CTD PMID:36370973 NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124
JBrowse link
G Doc2b double C2 domain beta decreases expression ISO Malathion results in decreased expression of DOC2B mRNA CTD PMID:37047231 NCBI chr10:60,628,029...60,653,267
Ensembl chr10:60,628,029...60,653,267
JBrowse link
G Dsp desmoplakin increases expression ISO Malathion results in increased expression of DSP mRNA CTD PMID:37047231 NCBI chr17:26,623,602...26,671,692
Ensembl chr17:26,623,588...26,671,800
JBrowse link
G Dspp dentin sialophosphoprotein decreases expression ISO Malathion results in decreased expression of DSPP mRNA CTD PMID:37047231 NCBI chr14:5,565,562...5,571,669
Ensembl chr14:5,565,629...5,571,672
JBrowse link
G Dtna dystrobrevin, alpha decreases expression ISO Malathion results in decreased expression of DTNA mRNA CTD PMID:37047231 NCBI chr18:14,687,193...14,944,232
Ensembl chr18:14,587,852...14,944,261
JBrowse link
G Duox1 dual oxidase 1 multiple interactions
increases expression
ISO Plant Extracts inhibits the reaction [Malathion results in increased expression of DUOX1 protein]; Polyphenols inhibits the reaction [Malathion results in increased expression of DUOX1 protein] CTD PMID:32120800 NCBI chr 3:109,260,526...109,295,588
Ensembl chr 3:109,262,397...109,295,563
JBrowse link
G Dusp1 dual specificity phosphatase 1 decreases expression ISO Malathion results in decreased expression of DUSP1 mRNA CTD PMID:32069766 NCBI chr10:16,680,478...16,683,275 JBrowse link
G Dusp5 dual specificity phosphatase 5 increases expression ISO Malathion results in increased expression of DUSP5 mRNA CTD PMID:37047231 NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818
JBrowse link
G Dvl1 dishevelled segment polarity protein 1 increases expression ISO Malathion results in increased expression of DVL1 mRNA CTD PMID:18204794 NCBI chr 5:166,456,989...166,468,733
Ensembl chr 5:166,456,686...166,468,664
JBrowse link
G Ebi3 Epstein-Barr virus induced 3 increases expression ISO Malathion results in increased expression of EBI3 mRNA CTD PMID:37047231 NCBI chr 9:774,252...787,544
Ensembl chr 9:783,617...787,544
JBrowse link
G Edn1 endothelin 1 increases expression ISO Malathion results in increased expression of EDN1 mRNA CTD PMID:37047231 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Ednrb endothelin receptor type B decreases expression ISO Malathion results in decreased expression of EDNRB mRNA CTD PMID:37047231 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
JBrowse link
G Efcab9 EF-hand calcium binding domain 9 increases expression ISO Malathion results in increased expression of EFCAB9 mRNA CTD PMID:37047231 NCBI chr10:17,107,123...17,112,282
Ensembl chr10:17,107,123...17,112,289
JBrowse link
G Ehbp1 EH domain binding protein 1 increases response to substance ISO EHBP1 gene SNP results in increased susceptibility to Malathion CTD PMID:23593118 NCBI chr14:96,093,327...96,380,502
Ensembl chr14:96,093,327...96,345,332
JBrowse link
G En1 engrailed homeobox 1 decreases expression ISO Malathion results in decreased expression of EN1 mRNA CTD PMID:37047231 NCBI chr13:31,750,892...31,756,477
Ensembl chr13:31,751,545...31,755,943
JBrowse link
G Enkur enkurin, TRPC channel interacting protein increases expression ISO Malathion results in increased expression of ENKUR mRNA CTD PMID:37047231 NCBI chr17:83,690,105...83,714,756
Ensembl chr17:83,690,797...83,714,408
JBrowse link
G Epha10 EPH receptor A10 increases expression ISO Malathion results in increased expression of EPHA10 mRNA CTD PMID:37047231 NCBI chr 5:137,139,588...137,175,637
Ensembl chr 5:137,140,735...137,174,157
JBrowse link
G Epha4 Eph receptor A4 increases expression ISO Malathion results in increased expression of EPHA4 mRNA CTD PMID:32069766 NCBI chr 9:78,815,460...78,958,139
Ensembl chr 9:78,815,460...78,958,139
JBrowse link
G Ephx1 epoxide hydrolase 1 decreases expression ISO Malathion results in decreased expression of EPHX1 mRNA CTD PMID:17311802 NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235
JBrowse link
G Epop elongin BC and polycomb repressive complex 2 associated protein increases expression ISO Malathion results in increased expression of EPOP mRNA CTD PMID:37047231 NCBI chr10:82,624,392...82,625,912
Ensembl chr10:82,624,392...82,625,912
JBrowse link
G Eps8l1 EPS8-like 1 increases expression ISO Malathion results in increased expression of EPS8L1 mRNA CTD PMID:32069766 NCBI chr 1:69,343,202...69,359,778
Ensembl chr 1:69,344,243...69,363,524
JBrowse link
G Erbb4 erb-b2 receptor tyrosine kinase 4 increases expression ISO Malathion results in increased expression of ERBB4 mRNA CTD PMID:37047231 NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595
JBrowse link
G Esr1 estrogen receptor 1 decreases activity ISO Malathion results in decreased activity of ESR1 protein CTD PMID:22562034 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Etv6 ETS variant transcription factor 6 increases expression ISO Malathion results in increased expression of ETV6 mRNA mutant form CTD PMID:28624474 NCBI chr 4:166,849,031...167,085,211
Ensembl chr 4:166,847,686...167,084,992
JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO Malathion results in increased expression of F3 mRNA CTD PMID:37047231 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Fam124a family with sequence similarity 124 member A increases expression ISO Malathion results in increased expression of FAM124A mRNA CTD PMID:37047231 NCBI chr15:36,799,836...36,855,062
Ensembl chr15:36,799,877...36,853,683
JBrowse link
G Fam227b family with sequence similarity 227, member B decreases expression ISO Malathion results in decreased expression of FAM227B mRNA CTD PMID:37047231 NCBI chr 3:113,226,662...113,392,396
Ensembl chr 3:113,233,205...113,392,320
JBrowse link
G Fam229b family with sequence similarity 229, member B decreases expression ISO Malathion results in decreased expression of FAM229B mRNA CTD PMID:37047231 NCBI chr20:42,538,853...42,552,355
Ensembl chr20:42,538,868...42,552,248
JBrowse link
G Fgf22 fibroblast growth factor 22 decreases expression ISO Malathion results in decreased expression of FGF22 mRNA CTD PMID:37047231 NCBI chr 7:9,947,632...9,956,918
Ensembl chr 7:9,948,071...9,950,486
JBrowse link
G Fgf6 fibroblast growth factor 6 increases expression ISO Malathion results in increased expression of FGF6 mRNA CTD PMID:32069766 NCBI chr 4:159,854,913...159,863,447
Ensembl chr 4:159,854,913...159,863,447
JBrowse link
G Fgfbp1 fibroblast growth factor binding protein 1 increases expression ISO Malathion results in increased expression of FGFBP1 mRNA CTD PMID:37047231 NCBI chr14:67,103,686...67,107,492
Ensembl chr14:67,104,545...67,107,496
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 increases expression ISO Malathion results in increased expression of FGFR1 mRNA CTD PMID:32069766 NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350
JBrowse link
G Fgg fibrinogen gamma chain decreases expression ISO Malathion results in decreased expression of FGG mRNA CTD PMID:37047231 NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322
JBrowse link
G Filip1l filamin A interacting protein 1-like increases expression ISO Malathion results in increased expression of FILIP1L mRNA CTD PMID:37047231 NCBI chr11:42,937,353...43,177,085
Ensembl chr11:42,940,467...43,177,415
JBrowse link
G Flt4 Fms related receptor tyrosine kinase 4 increases expression ISO Malathion results in increased expression of FLT4 mRNA CTD PMID:37047231 NCBI chr10:33,913,725...33,954,770
Ensembl chr10:33,913,608...33,954,770
JBrowse link
G Foxo1 forkhead box O1 decreases expression
increases methylation
multiple interactions
EXP Malathion results in decreased expression of FOXO1 mRNA
Malathion results in increased methylation of FOXO1 promoter
[Malathion results in increased methylation of FOXO1 promoter] which results in decreased expression of FOXO1 mRNA
CTD PMID:36370973 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
JBrowse link
G Foxo4 forkhead box O4 increases expression ISO Malathion results in increased expression of FOXO4 mRNA CTD PMID:32069766 NCBI chr  X:66,385,241...66,392,115
Ensembl chr  X:66,385,558...66,392,115
JBrowse link
G Fshr follicle stimulating hormone receptor increases expression ISO Malathion results in increased expression of FSHR mRNA CTD PMID:32069766 NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase multiple interactions
increases activity
EXP [Malathion co-treated with Carbaryl] results in increased activity of G6PD protein; Plant Extracts inhibits the reaction [[Malathion co-treated with Carbaryl] results in increased activity of G6PD protein]
Malathion results in increased activity of G6PD protein
CTD PMID:27214522 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gad1 glutamate decarboxylase 1 affects binding ISO Malathion binds to [GAD1 protein binds to Pyridoxal Phosphate]; Malathion binds to GAD1 protein CTD PMID:35151785 NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333
JBrowse link
G Gad2 glutamate decarboxylase 2 affects binding ISO Malathion binds to [GAD2 protein binds to Pyridoxal Phosphate]; Malathion binds to GAD2 protein CTD PMID:35151785 NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155
JBrowse link
G Galnt16 polypeptide N-acetylgalactosaminyltransferase 16 increases expression ISO Malathion results in increased expression of GALNT16 mRNA CTD PMID:37047231 NCBI chr 6:100,168,943...100,250,718
Ensembl chr 6:100,170,306...100,250,705
JBrowse link
G Garin2 golgi associated RAB2 interactor family member 2 decreases expression ISO Malathion results in decreased expression of GARIN2 mRNA CTD PMID:37047231 NCBI chr 6:97,489,562...97,534,729
Ensembl chr 6:97,490,368...97,534,763
JBrowse link
G Gas2 growth arrest-specific 2 increases expression ISO Malathion results in increased expression of GAS2 mRNA CTD PMID:37047231 NCBI chr 1:101,452,361...101,582,619
Ensembl chr 1:101,482,591...101,582,619
JBrowse link
G Gata4 GATA binding protein 4 decreases expression ISO Malathion results in decreased expression of GATA4 mRNA CTD PMID:37047231 NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636
JBrowse link
G Gbp1 guanylate binding protein 1 increases expression ISO Malathion results in increased expression of GBP1 mRNA CTD PMID:37047231 NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,398,163...231,432,131
Ensembl chr 2:231,398,163...231,432,131
JBrowse link
G Gbp3 guanylate binding protein 3 increases expression ISO Malathion results in increased expression of GBP3 mRNA CTD PMID:37047231 NCBI chr 2:231,460,032...231,500,266
Ensembl chr 2:231,486,062...231,493,098
JBrowse link
G Gbp5 guanylate binding protein 5 increases expression ISO Malathion results in increased expression of GBP5 mRNA CTD PMID:37047231 NCBI chr 2:231,237,748...231,257,071
Ensembl chr 2:231,237,748...231,257,061
JBrowse link
G Gk glycerol kinase multiple interactions
increases activity
EXP Acetylcysteine inhibits the reaction [Malathion results in increased activity of GK protein] CTD PMID:25449180 NCBI chr  X:50,162,089...50,238,707
Ensembl chr  X:50,163,123...50,238,631
JBrowse link
G Gk2 glycerol kinase 2 decreases expression EXP Malathion results in decreased expression of GK2 mRNA CTD PMID:25449180 NCBI chr14:12,107,071...12,108,923
Ensembl chr14:12,107,020...12,128,473
JBrowse link
G Gmnc geminin coiled-coil domain containing increases expression ISO Malathion results in increased expression of GMNC mRNA CTD PMID:37047231 NCBI chr11:73,836,255...73,847,698
Ensembl chr11:73,814,533...73,847,328
JBrowse link
G Gnai1 G protein subunit alpha i1 increases expression ISO Malathion results in increased expression of GNAI1 mRNA CTD PMID:37047231 NCBI chr 4:16,814,000...16,898,119
Ensembl chr 4:16,814,001...16,896,417
JBrowse link
G Gnai2 G protein subunit alpha i2 decreases expression ISO Malathion results in decreased expression of GNAI2 mRNA CTD PMID:32069766 NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979
JBrowse link
G Got1l1 glutamic-oxaloacetic transaminase 1-like 1 increases expression ISO Malathion results in increased expression of GOT1L1 mRNA CTD PMID:37047231 NCBI chr16:64,860,308...64,873,656
Ensembl chr16:64,860,704...64,866,162
JBrowse link
G Gp5 glycoprotein V (platelet) increases expression ISO Malathion results in increased expression of GP5 mRNA CTD PMID:37047231 NCBI chr11:70,443,613...70,446,705
Ensembl chr11:70,443,613...70,446,705
JBrowse link
G Gpr179 G protein-coupled receptor 179 decreases expression ISO Malathion results in decreased expression of GPR179 mRNA CTD PMID:37047231 NCBI chr10:82,324,568...82,340,448
Ensembl chr10:82,337,771...82,340,448
JBrowse link
G Gps2 G protein pathway suppressor 2 decreases expression ISO Malathion results in decreased expression of GPS2 mRNA CTD PMID:32069766 NCBI chr10:54,637,360...54,640,542
Ensembl chr10:54,637,455...54,640,650
JBrowse link
G Gpt glutamic--pyruvic transaminase increases activity EXP Malathion results in increased activity of GPT protein CTD PMID:25180440 PMID:36370973 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gramd4 GRAM domain containing 4 decreases expression ISO Malathion results in decreased expression of GRAMD4 mRNA CTD PMID:32069766 NCBI chr 7:117,150,398...117,224,056
Ensembl chr 7:117,150,374...117,224,053
JBrowse link
G Grk1 G protein-coupled receptor kinase 1 increases expression ISO Malathion results in increased expression of GRK1 mRNA CTD PMID:37047231 NCBI chr16:76,122,501...76,135,792
Ensembl chr16:76,123,842...76,135,792
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases expression EXP Malathion results in increased expression of GSK3B mRNA CTD PMID:25449180 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
decreases activity
ISO
EXP
[Hexachlorocyclohexane co-treated with Malathion] results in decreased activity of GSR protein
zinc chloride inhibits the reaction [Malathion results in decreased activity of GSR protein]
CTD PMID:16718366 PMID:19429256 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases expression ISO Malathion results in decreased expression of GSTP1 mRNA CTD PMID:32069766 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Gzmb granzyme B decreases expression
multiple interactions
ISO Malathion results in decreased expression of GZMB protein
Plant Extracts inhibits the reaction [Malathion results in decreased expression of GZMB protein]; Polyphenols inhibits the reaction [Malathion results in decreased expression of GZMB protein]
CTD PMID:32120800 NCBI chr15:30,343,352...30,346,814
Ensembl chr15:30,173,603...30,346,814
JBrowse link
G H19 H19 imprinted maternally expressed transcript increases expression ISO Malathion results in increased expression of H19 mRNA CTD PMID:37047231 NCBI chr 1:197,730,698...197,733,374
Ensembl chr 1:197,730,698...197,733,134
JBrowse link
G Has1 hyaluronan synthase 1 increases expression ISO Malathion results in increased expression of HAS1 mRNA CTD PMID:37047231 NCBI chr 1:58,693,411...58,705,653
Ensembl chr 1:58,693,411...58,705,397
JBrowse link
G Hbegf heparin-binding EGF-like growth factor increases expression ISO Malathion results in increased expression of HBEGF mRNA CTD PMID:37047231 NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441
JBrowse link
G Hdc histidine decarboxylase affects binding ISO Malathion binds to [HDC protein binds to Pyridoxal Phosphate]; Malathion binds to HDC protein CTD PMID:35151785 NCBI chr 3:113,847,256...113,865,334
Ensembl chr 3:113,847,260...113,865,341
JBrowse link
G Hilpda hypoxia inducible lipid droplet-associated increases expression ISO Malathion results in increased expression of HILPDA mRNA CTD PMID:37047231 NCBI chr 4:57,871,088...57,874,048
Ensembl chr 4:57,871,110...57,874,557
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP Malathion results in increased expression of HMOX1 protein CTD PMID:34778934 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hnmt histamine N-methyltransferase decreases expression ISO Malathion results in decreased expression of HNMT mRNA CTD PMID:37047231 NCBI chr 3:6,591,804...6,623,821
Ensembl chr 3:6,591,463...6,624,012
JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions
increases expression
ISO [Malathion co-treated with Estrogens] results in increased expression of HRAS mRNA
Malathion results in increased expression of HRAS mRNA; Malathion results in increased expression of HRAS protein
CTD PMID:18204794 PMID:19787260 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 multiple interactions
decreases expression
ISO
EXP
lavender oil inhibits the reaction [Malathion results in decreased expression of HSD17B3 mRNA] CTD PMID:30409133 PMID:36336997 NCBI chr17:1,027,229...1,058,554
Ensembl chr17:1,027,229...1,058,554
JBrowse link
G Hsf2bp heat shock transcription factor 2 binding protein increases expression ISO Malathion results in increased expression of HSF2BP mRNA CTD PMID:37047231 NCBI chr20:10,035,562...10,123,059
Ensembl chr20:10,035,562...10,121,242
JBrowse link
G Hspb2 heat shock protein family B (small) member 2 increases expression ISO Malathion results in increased expression of HSPB2 protein CTD PMID:19607909 NCBI chr 8:51,093,267...51,094,528
Ensembl chr 8:51,081,342...51,094,533
JBrowse link
G Htatip2 HIV-1 Tat interactive protein 2 decreases expression ISO Malathion results in decreased expression of HTATIP2 mRNA CTD PMID:32069766 NCBI chr 1:99,473,411...99,488,632
Ensembl chr 1:99,469,245...99,488,629
JBrowse link
G Htra4 HtrA serine peptidase 4 decreases expression ISO Malathion results in decreased expression of HTRA4 mRNA CTD PMID:37047231 NCBI chr16:67,001,605...67,015,074
Ensembl chr16:67,001,605...67,015,074
JBrowse link
G Ido1 indoleamine 2,3-dioxygenase 1 increases expression ISO Malathion results in increased expression of IDO1 mRNA CTD PMID:37047231 NCBI chr16:67,430,654...67,442,726
Ensembl chr16:67,430,578...67,442,730
JBrowse link
G Ifi44l interferon-induced protein 44-like increases expression ISO Malathion results in increased expression of IFI44L mRNA CTD PMID:37047231 NCBI chr 2:240,668,742...240,706,425
Ensembl chr 2:240,668,713...240,706,359
JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO Malathion inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA] CTD PMID:18177342 NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523
JBrowse link
G Ifng interferon gamma decreases expression
multiple interactions
increases expression
EXP
ISO
Malathion results in decreased expression of IFNG protein
Plant Extracts inhibits the reaction [Malathion results in decreased expression of IFNG protein]; Polyphenols inhibits the reaction [Malathion results in decreased expression of IFNG protein]
Malathion results in increased expression of IFNG mRNA
Acetylcysteine inhibits the reaction [Malathion results in increased expression of IFNG mRNA]; Taurine inhibits the reaction [Malathion results in increased expression of IFNG mRNA]
CTD PMID:19145326 PMID:24810974 PMID:25180440 PMID:28987951 PMID:32120800 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il11 interleukin 11 increases expression ISO Malathion results in increased expression of IL11 mRNA CTD PMID:37047231 NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129
JBrowse link
G Il13 interleukin 13 increases expression ISO Malathion results in increased expression of IL13 mRNA CTD PMID:37047231 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il13ra2 interleukin 13 receptor subunit alpha 2 increases expression ISO Malathion results in increased expression of IL13RA2 mRNA CTD PMID:32069766 NCBI chr  X:111,002,590...111,074,053
Ensembl chr  X:111,002,592...111,072,381
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Malathion results in increased expression of IL1A mRNA CTD PMID:37047231 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
EXP
ISO
Acetylcysteine inhibits the reaction [Malathion results in increased expression of IL1B mRNA]; Taurine inhibits the reaction [Malathion results in increased expression of IL1B mRNA] CTD PMID:24810974 PMID:25180440 PMID:28987951 PMID:37047231 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il1r2 interleukin 1 receptor type 2 decreases expression EXP Malathion results in decreased expression of IL1R2 mRNA CTD PMID:19784758 NCBI chr 9:42,384,280...42,424,726
Ensembl chr 9:42,384,433...42,424,725
JBrowse link
G Il2 interleukin 2 multiple interactions
decreases expression
ISO Plant Extracts inhibits the reaction [Malathion results in decreased expression of IL2 protein]; Polyphenols inhibits the reaction [Malathion results in decreased expression of IL2 protein] CTD PMID:32120800 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il23a interleukin 23 subunit alpha increases expression ISO Malathion results in increased expression of IL23A mRNA CTD PMID:37047231 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
JBrowse link
G Il24 interleukin 24 increases expression ISO Malathion results in increased expression of IL24 mRNA CTD PMID:37047231 NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
JBrowse link
G Il36g interleukin 36, gamma increases expression ISO Malathion results in increased expression of IL36G mRNA CTD PMID:37047231 NCBI chr 3:6,948,323...6,954,485
Ensembl chr 3:6,948,297...6,954,480
JBrowse link
G Il4 interleukin 4 decreases expression
multiple interactions
ISO Malathion results in decreased expression of IL4 protein
Plant Extracts inhibits the reaction [Malathion results in decreased expression of IL4 protein]; Polyphenols inhibits the reaction [Malathion results in decreased expression of IL4 protein]
CTD PMID:32120800 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression
EXP
ISO
Acetylcysteine inhibits the reaction [Malathion results in increased expression of IL6 mRNA] CTD PMID:24810974 PMID:25180440 PMID:37047231 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Inhba inhibin subunit beta A increases expression
decreases methylation
ISO Malathion results in increased expression of INHBA mRNA
Malathion results in decreased methylation of INHBA promoter
CTD PMID:37047231 NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982
JBrowse link
G Ins1 insulin 1 increases expression EXP Malathion results in increased expression of INS1 protein CTD PMID:25449180 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 increases expression ISO Malathion results in increased expression of IRAK1 mRNA CTD PMID:32069766 NCBI chr  X:151,768,621...151,778,521
Ensembl chr  X:151,768,777...151,778,521
JBrowse link
G Irak2 interleukin-1 receptor-associated kinase 2 increases expression ISO Malathion results in increased expression of IRAK2 mRNA CTD PMID:37047231 NCBI chr 4:146,786,004...146,842,615
Ensembl chr 4:146,786,100...146,842,602
JBrowse link
G Irx2 iroquois homeobox 2 increases expression ISO Malathion results in increased expression of IRX2 mRNA CTD PMID:37047231 NCBI chr 1:30,660,960...30,666,378
Ensembl chr 1:30,660,960...30,666,378
JBrowse link
G Itgb8 integrin subunit beta 8 decreases methylation
increases expression
ISO Malathion results in decreased methylation of ITGB8 promoter
Malathion results in increased expression of ITGB8 mRNA
CTD PMID:37047231 NCBI chr 6:140,125,002...140,208,261
Ensembl chr 6:140,127,203...140,208,476
JBrowse link
G Kazn kazrin, periplakin interacting protein decreases expression ISO Malathion results in decreased expression of KAZN mRNA CTD PMID:37047231 NCBI chr 5:154,392,793...155,381,567
Ensembl chr 5:154,392,793...154,779,074
JBrowse link
G Kcnh5 potassium voltage-gated channel subfamily H member 5 increases expression ISO Malathion results in increased expression of KCNH5 mRNA CTD PMID:37047231 NCBI chr 6:93,615,174...93,908,107
Ensembl chr 6:93,624,529...93,908,107
JBrowse link
G Kcnma1 potassium calcium-activated channel subfamily M alpha 1 increases methylation
decreases expression
ISO Malathion results in increased methylation of KCNMA1 promoter
Malathion results in decreased expression of KCNMA1 mRNA
CTD PMID:37047231 NCBI chr15:302,480...1,007,675
Ensembl chr15:302,214...1,001,198
JBrowse link
G Kif6 kinesin family member 6 decreases expression ISO Malathion results in decreased expression of KIF6 mRNA CTD PMID:37047231 NCBI chr 9:11,076,203...11,373,205
Ensembl chr 9:11,072,824...11,373,006
JBrowse link
G Kmt2a lysine methyltransferase 2A increases mutagenesis
increases expression
ISO Malathion results in increased mutagenesis of KMT2A gene
Malathion results in increased expression of KMT2A mRNA mutant form
CTD PMID:28624474 NCBI chr 8:45,116,763...45,193,320
Ensembl chr 8:45,118,814...45,193,181
JBrowse link
G Krt14 keratin 14 increases expression ISO Malathion results in increased expression of KRT14 mRNA CTD PMID:37047231 NCBI chr10:85,137,786...85,142,054
Ensembl chr10:85,066,802...85,171,799
JBrowse link
G Krt17 keratin 17 increases expression ISO Malathion results in increased expression of KRT17 mRNA CTD PMID:37047231 NCBI chr10:85,178,673...85,183,392
Ensembl chr10:85,178,675...85,183,392
JBrowse link
G Krtap27-1 keratin associated protein 27-1 increases expression ISO Malathion results in increased expression of KRTAP27-1 mRNA CTD PMID:37047231 NCBI chr11:27,980,875...27,982,002 JBrowse link
G L1td1 LINE-1 type transposase domain containing 1 affects expression
multiple interactions
increases methylation
EXP Malathion affects the expression of L1TD1 mRNA
[Malathion results in increased methylation of L1TD1 promoter] which affects the expression of L1TD1 mRNA
CTD PMID:36370973 NCBI chr 5:113,373,193...113,386,088
Ensembl chr 5:113,379,870...113,385,730
JBrowse link
G Lat linker for activation of T cells increases expression EXP Malathion results in increased expression of LAT mRNA CTD PMID:19784758 NCBI chr 1:180,936,536...180,941,561
Ensembl chr 1:180,936,534...180,941,578
JBrowse link
G Lcorl ligand dependent nuclear receptor corepressor-like increases expression ISO Malathion results in increased expression of LCORL mRNA CTD PMID:37047231 NCBI chr14:65,271,339...65,407,732
Ensembl chr14:65,271,135...65,404,174
JBrowse link
G Lelp1 late cornified envelope-like proline-rich 1 decreases expression ISO Malathion results in decreased expression of LELP1 mRNA CTD PMID:37047231
G Lemd1 LEM domain containing 1 increases expression ISO Malathion results in increased expression of LEMD1 mRNA CTD PMID:37047231 NCBI chr13:43,631,705...43,697,765
Ensembl chr13:43,665,926...43,697,948
JBrowse link
G Lgals1 galectin 1 decreases expression ISO Malathion results in decreased expression of LGALS1 mRNA CTD PMID:32069766 NCBI chr 7:110,485,239...110,488,345
Ensembl chr 7:110,481,392...110,488,345
JBrowse link
G Lif LIF, interleukin 6 family cytokine increases expression ISO Malathion results in increased expression of LIF mRNA CTD PMID:37047231 NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482
JBrowse link
G Lin28b lin-28 homolog B increases expression ISO Malathion results in increased expression of LIN28B mRNA CTD PMID:37047231 NCBI chr20:48,865,329...48,964,769
Ensembl chr20:48,869,485...48,955,077
JBrowse link
G Lingo1 leucine rich repeat and Ig domain containing 1 decreases expression ISO Malathion results in decreased expression of LINGO1 mRNA CTD PMID:37047231 NCBI chr 8:57,011,272...57,193,496
Ensembl chr 8:57,010,007...57,196,544
JBrowse link
G Lmbr1 limb development membrane protein 1 increases expression ISO Malathion results in increased expression of LMBR1 mRNA CTD PMID:37047231 NCBI chr 4:5,974,687...6,146,348
Ensembl chr 4:5,974,750...6,146,368
JBrowse link
G LOC120095955 mucin-12-like decreases expression ISO Malathion results in decreased expression of MUC12 mRNA CTD PMID:37047231 NCBI chr12:19,486,041...19,493,995 JBrowse link
G Lpcat4 lysophosphatidylcholine acyltransferase 4 increases expression ISO Malathion results in increased expression of LPCAT4 mRNA CTD PMID:32069766 NCBI chr 3:99,044,729...99,052,963
Ensembl chr 3:99,044,729...99,052,875
JBrowse link
G Lrguk leucine-rich repeats and guanylate kinase domain containing decreases expression ISO Malathion results in decreased expression of LRGUK mRNA CTD PMID:37047231 NCBI chr 4:62,647,222...62,770,268
Ensembl chr 4:62,647,264...62,770,319
JBrowse link
G Lrp3 LDL receptor related protein 3 decreases expression ISO Malathion results in decreased expression of LRP3 mRNA CTD PMID:37047231 NCBI chr 1:87,843,815...87,859,147
Ensembl chr 1:87,844,868...87,859,110
JBrowse link
G Lypd1 Ly6/Plaur domain containing 1 decreases expression ISO Malathion results in decreased expression of LYPD1 mRNA CTD PMID:37047231 NCBI chr13:37,326,459...37,368,515
Ensembl chr13:37,326,464...37,368,493
JBrowse link
G Lzts1 leucine zipper tumor suppressor 1 increases expression ISO Malathion results in increased expression of LZTS1 mRNA CTD PMID:37047231 NCBI chr16:20,542,756...20,598,204
Ensembl chr16:20,542,809...20,598,203
JBrowse link
G Lzts2 leucine zipper tumor suppressor 2 decreases expression ISO Malathion results in decreased expression of LZTS2 mRNA CTD PMID:32069766 NCBI chr 1:243,876,665...243,888,489
Ensembl chr 1:243,880,022...243,888,423
JBrowse link
G Macrod2 mono-ADP ribosylhydrolase 2 decreases expression ISO Malathion results in decreased expression of MACROD2 mRNA CTD PMID:37047231 NCBI chr 3:127,720,066...129,737,511
Ensembl chr 3:127,720,181...129,734,492
JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 decreases expression ISO Malathion results in decreased expression of MAP2K3 mRNA CTD PMID:32069766 NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492
JBrowse link
G Marchf3 membrane associated ring-CH-type finger 3 increases expression ISO Malathion results in increased expression of MARCHF3 mRNA CTD PMID:37047231 NCBI chr18:50,237,218...50,389,343
Ensembl chr18:50,237,230...50,389,150
JBrowse link
G Mbp myelin basic protein decreases expression ISO Malathion results in decreased expression of MBP mRNA CTD PMID:37047231 NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404
JBrowse link
G Mcm2 minichromosome maintenance complex component 2 multiple interactions
increases expression
ISO [Malathion co-treated with Estrogens] results in increased expression of MCM2 mRNA
Malathion results in increased expression of MCM2 mRNA
CTD PMID:18204794 NCBI chr 4:121,346,434...121,360,962
Ensembl chr 4:121,346,434...121,360,847
JBrowse link
G Meis1 Meis homeobox 1 decreases expression ISO Malathion results in decreased expression of MEIS1 mRNA CTD PMID:37047231 NCBI chr14:93,155,426...93,294,373
Ensembl chr14:93,155,419...93,294,265
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases expression ISO Malathion results in increased expression of MET mRNA CTD PMID:37047231 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
JBrowse link
G Mfsd2a MFSD2 lysolipid transporter A, lysophospholipid increases expression ISO Malathion results in increased expression of MFSD2A mRNA CTD PMID:37047231 NCBI chr 5:135,225,801...135,240,744
Ensembl chr 5:135,225,816...135,240,690
JBrowse link
G Mill1 MHC I like leukocyte 1 increases expression ISO Malathion results in increased expression of MICA mRNA CTD PMID:32069766 NCBI chr 1:78,372,798...78,398,932
Ensembl chr 1:78,372,802...78,398,930
JBrowse link
G Mmp1 matrix metallopeptidase 1 increases expression ISO Malathion results in increased expression of MMP1 mRNA CTD PMID:37047231 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mmp10 matrix metallopeptidase 10 increases expression ISO Malathion results in increased expression of MMP10 mRNA CTD PMID:37047231 NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748
JBrowse link
G Mmp12 matrix metallopeptidase 12 increases expression ISO Malathion results in increased expression of MMP12 mRNA CTD PMID:37047231 NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611
JBrowse link
G Mmp3 matrix metallopeptidase 3 increases expression ISO Malathion results in increased expression of MMP3 mRNA CTD PMID:37047231 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
JBrowse link
G Mpo myeloperoxidase multiple interactions
increases activity
EXP Acetylcysteine inhibits the reaction [Malathion results in increased activity of MPO protein] CTD PMID:24810974 PMID:25180440 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I decreases expression ISO Malathion results in decreased expression of COX1 mRNA CTD PMID:18214912 NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
JBrowse link
G Mt-co3 mitochondrially encoded cytochrome c oxidase III decreases expression ISO Malathion results in decreased expression of COX3 mRNA CTD PMID:18214912 NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382
JBrowse link
G Mt1-ps3 metallothionein 1, pseudogene 3 increases expression ISO Malathion results in increased expression of MT1E mRNA CTD PMID:37047231 NCBI chr17:74,786,652...74,787,040
Ensembl chr17:74,786,654...74,787,135
JBrowse link
G Mt2A metallothionein 2A increases expression ISO Malathion results in increased expression of MT2A mRNA CTD PMID:37047231 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
JBrowse link
G Mybphl myosin binding protein H-like increases expression ISO Malathion results in increased expression of MYBPHL mRNA CTD PMID:37047231 NCBI chr 2:196,005,297...196,018,826
Ensembl chr 2:196,005,325...196,018,824
JBrowse link
G Myo1b myosin Ib increases expression ISO Malathion results in increased expression of MYO1B mRNA CTD PMID:37047231 NCBI chr 9:49,690,043...49,852,373
Ensembl chr 9:49,690,086...49,850,798
JBrowse link
G Myzap myocardial zonula adherens protein increases expression ISO Malathion results in increased expression of MYZAP mRNA CTD PMID:37047231 NCBI chr 8:72,155,817...72,243,036
Ensembl chr 8:72,131,530...72,243,036
JBrowse link
G Ndufs7 NADH:ubiquinone oxidoreductase core subunit S7 decreases expression ISO Malathion results in decreased expression of NDUFS7 mRNA CTD PMID:37047231 NCBI chr 7:9,452,556...9,460,135
Ensembl chr 7:9,450,392...9,460,195
JBrowse link
G Nefh neurofilament heavy chain affects expression
increases expression
EXP Malathion affects the expression of NEFH mRNA
Malathion results in increased expression of NEFH mRNA
CTD PMID:22954530 PMID:28385489 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
JBrowse link
G Nek10 NIMA-related kinase 10 decreases expression ISO Malathion results in decreased expression of NEK10 mRNA CTD PMID:37047231 NCBI chr15:10,387,063...10,564,177
Ensembl chr15:10,381,140...10,559,722
JBrowse link
G Neu4 neuraminidase 4 increases expression ISO Malathion results in increased expression of NEU4 mRNA CTD PMID:37047231 NCBI chr 9:94,396,920...94,402,576
Ensembl chr 9:94,396,920...94,402,576
JBrowse link
G Neurl3 neuralized E3 ubiquitin protein ligase 3 increases expression ISO Malathion results in increased expression of NEURL3 mRNA CTD PMID:37047231 NCBI chr 9:38,494,486...38,503,352
Ensembl chr 9:38,494,489...38,502,649
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases activity ISO Malathion results in increased activity of NFE2L2 protein CTD PMID:30114225 PMID:30203046 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfib nuclear factor I/B decreases expression ISO Malathion results in decreased expression of NFIB mRNA CTD PMID:37047231 NCBI chr 5:96,759,208...96,974,001
Ensembl chr 5:96,764,653...96,975,479
JBrowse link
G Ngf nerve growth factor multiple interactions EXP Malathion promotes the reaction [NGF protein results in increased expression of CAMK2A mRNA]; Malathion promotes the reaction [NGF protein results in increased expression of CAMK2B mRNA] CTD PMID:28385489 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Ninj1 ninjurin 1 decreases expression ISO Malathion results in decreased expression of NINJ1 mRNA CTD PMID:32069766 NCBI chr17:15,452,804...15,461,684
Ensembl chr17:15,452,813...15,461,704
JBrowse link
G Nnt nicotinamide nucleotide transhydrogenase decreases expression ISO Malathion results in decreased expression of NNT mRNA CTD PMID:37047231 NCBI chr 2:51,411,413...51,505,125
Ensembl chr 2:51,411,413...51,504,823
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression EXP Malathion results in increased expression of NOS2 mRNA CTD PMID:20233601 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO Malathion results in increased expression of NQO1 mRNA CTD PMID:17311802 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases expression
increases activity
ISO Malathion results in increased expression of NR1I3 mRNA
Malathion results in increased activity of NR1I3 protein
CTD PMID:22310298 PMID:28927721 PMID:30203046 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression ISO Malathion results in increased expression of NR4A1 mRNA CTD PMID:37047231 NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 decreases methylation
increases expression
ISO Malathion results in decreased methylation of NR4A3 promoter
Malathion results in increased expression of NR4A3 mRNA
CTD PMID:37047231 NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733
JBrowse link
G Ntn1 netrin 1 increases expression ISO Malathion results in increased expression of NTN1 mRNA CTD PMID:37047231 NCBI chr10:52,899,933...53,098,591
Ensembl chr10:52,899,934...53,085,326
JBrowse link
G Ntrk2 neurotrophic receptor tyrosine kinase 2 increases expression ISO Malathion results in increased expression of NTRK2 mRNA CTD PMID:32069766 NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
JBrowse link
G Ocln occludin multiple interactions
decreases expression
EXP [Malathion co-treated with Lead] results in decreased expression of OCLN protein
Malathion results in decreased expression of OCLN protein
CTD PMID:20970449 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
JBrowse link
G Ocstamp osteoclast stimulatory transmembrane protein increases expression ISO Malathion results in increased expression of OCSTAMP mRNA CTD PMID:37047231 NCBI chr 3:154,131,113...154,141,611
Ensembl chr 3:154,132,328...154,136,991
JBrowse link
G Odam odontogenic, ameloblast associated decreases expression ISO Malathion results in decreased expression of ODAM mRNA CTD PMID:37047231 NCBI chr14:20,193,286...20,202,517
Ensembl chr14:20,193,302...20,202,517
JBrowse link
G Odf2l outer dense fiber of sperm tails 2-like decreases expression ISO Malathion results in decreased expression of ODF2L mRNA CTD PMID:37047231 NCBI chr 2:234,036,049...234,072,751
Ensembl chr 2:234,033,652...234,072,747
JBrowse link
G Olr1433 olfactory receptor 1433 increases expression ISO Malathion results in increased expression of OR2W3 mRNA CTD PMID:37047231 NCBI chr10:43,042,427...43,046,293
Ensembl chr10:43,037,857...43,046,701
JBrowse link
G Olr1523 olfactory receptor 1523 decreases expression ISO Malathion results in decreased expression of OR4D1 mRNA CTD PMID:37047231 NCBI chr10:72,708,272...72,709,213
Ensembl chr10:72,707,063...72,715,311
JBrowse link
G Olr35 olfactory receptor 35 decreases expression ISO Malathion results in decreased expression of OR2AT4 mRNA CTD PMID:37047231 NCBI chr 1:153,994,678...154,043,281
Ensembl chr 1:154,041,306...154,043,257
JBrowse link
G Omg oligodendrocyte-myelin glycoprotein affects expression ISO Malathion affects the expression of OMG mRNA CTD PMID:37047231 NCBI chr10:64,461,350...64,464,084
Ensembl chr10:64,461,350...64,464,084
JBrowse link
G Opn5 opsin 5 decreases expression ISO Malathion results in decreased expression of OPN5 mRNA CTD PMID:37047231 NCBI chr 9:18,368,393...18,416,098
Ensembl chr 9:18,368,416...18,415,476
JBrowse link
G Or4f7 olfactory receptor family 4 subfamily F member 7 decreases expression ISO Malathion results in decreased expression of OR4F29 mRNA CTD PMID:37047231 NCBI chr 3:98,482,895...98,483,833
Ensembl chr 3:98,481,730...98,489,462
JBrowse link
G Or4f7c olfactory receptor family 4 subfamily F member 7C decreases expression ISO Malathion results in decreased expression of OR4F21 mRNA CTD PMID:37047231 NCBI chr 3:98,458,889...98,459,827
Ensembl chr 3:98,457,871...98,464,794
JBrowse link
G Or6c2 olfactory receptor family 6 subfamily C member 2 decreases expression ISO Malathion results in decreased expression of OR6C2 mRNA CTD PMID:37047231 NCBI chr 7:2,188,601...2,189,539 JBrowse link
G Or9g4 olfactory receptor family 9 subfamily G member 4 decreases expression ISO Malathion results in decreased expression of OR9G4 mRNA CTD PMID:37047231 NCBI chr 3:70,727,963...70,728,901
Ensembl chr 3:70,726,935...70,732,439
JBrowse link
G P2rx1 purinergic receptor P2X 1 increases expression EXP Malathion results in increased expression of P2RX1 mRNA CTD PMID:19784758 NCBI chr10:57,618,586...57,633,648
Ensembl chr10:57,618,586...57,633,623
JBrowse link
G Palmd palmdelphin decreases expression ISO Malathion results in decreased expression of PALMD mRNA CTD PMID:37047231 NCBI chr 2:204,889,526...204,941,355
Ensembl chr 2:204,889,533...204,941,519
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO Malathion results in increased cleavage of PARP1 protein
Metoclopramide inhibits the reaction [Malathion results in increased cleavage of PARP1 protein]
CTD PMID:29027213 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pax1 paired box 1 increases expression ISO Malathion results in increased expression of PAX1 mRNA CTD PMID:32069766 NCBI chr 3:134,792,330...134,801,637
Ensembl chr 3:134,789,182...134,801,636
JBrowse link
G Pcdh15 protocadherin related 15 decreases expression ISO Malathion results in decreased expression of PCDH15 mRNA CTD PMID:37047231 NCBI chr20:13,997,094...15,496,446
Ensembl chr20:13,963,565...15,494,719
JBrowse link
G Pcdhb19 protocadherin beta 19 decreases expression ISO Malathion results in decreased expression of PCDHB12 mRNA CTD PMID:37047231 NCBI chr18:29,204,838...29,207,646 JBrowse link
G Pcdhgb1 protocadherin gamma subfamily B, 1 increases expression ISO Malathion results in increased expression of PCDHGB1 mRNA CTD PMID:37047231 NCBI chr18:29,501,739...29,508,024 JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions
increases expression
EXP Acetylcysteine inhibits the reaction [Malathion results in increased expression of PCK1 mRNA] CTD PMID:25449180 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions
increases expression
ISO Atropine inhibits the reaction [Malathion results in increased expression of PCNA] CTD PMID:12762645 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pde6c phosphodiesterase 6C decreases expression ISO Malathion results in decreased expression of PDE6C mRNA CTD PMID:37047231 NCBI chr 1:235,909,583...235,965,435
Ensembl chr 1:235,909,775...235,965,315
JBrowse link
G Pdia2 protein disulfide isomerase family A, member 2 decreases expression ISO Malathion results in decreased expression of PDIA2 mRNA CTD PMID:37047231 NCBI chr10:15,215,824...15,218,937
Ensembl chr10:15,215,824...15,220,931
JBrowse link
G Pebp1 phosphatidylethanolamine binding protein 1 decreases expression ISO Malathion results in decreased expression of PEBP1 mRNA CTD PMID:32069766 NCBI chr12:39,302,864...39,307,064
Ensembl chr12:39,302,840...39,307,862
JBrowse link
G Peg10 paternally expressed 10 increases expression ISO Malathion results in increased expression of PEG10 mRNA CTD PMID:37047231 NCBI chr 4:32,842,441...32,855,639
Ensembl chr 4:32,848,493...32,852,621
JBrowse link
G Pfn1 profilin 1 decreases expression ISO Malathion results in decreased expression of PFN1 mRNA CTD PMID:32069766 NCBI chr10:55,365,263...55,367,968
Ensembl chr10:55,365,262...55,527,631
JBrowse link
G Phb1 prohibitin 1 decreases expression ISO Malathion results in decreased expression of PHB1 mRNA CTD PMID:32069766 NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042
JBrowse link
G Pitx1 paired-like homeodomain 1 decreases expression ISO Malathion results in decreased expression of PITX1 mRNA CTD PMID:37047231 NCBI chr17:8,794,134...8,800,292
Ensembl chr17:8,794,134...8,800,291
JBrowse link
G Plat plasminogen activator, tissue type decreases expression ISO Malathion results in decreased expression of PLAT mRNA CTD PMID:16079077 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
JBrowse link
G Plau plasminogen activator, urokinase increases expression ISO Malathion results in increased expression of PLAU mRNA CTD PMID:32069766 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
JBrowse link
G Plaur plasminogen activator, urokinase receptor increases expression ISO Malathion results in increased expression of PLAUR mRNA CTD PMID:37047231 NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595
JBrowse link
G Plcb4 phospholipase C, beta 4 increases expression ISO Malathion results in increased expression of PLCB4 mRNA CTD PMID:37047231 NCBI chr 3:122,952,965...123,322,522
Ensembl chr 3:122,953,196...123,322,392
JBrowse link
G Plekhd1 pleckstrin homology and coiled-coil domain containing D1 decreases expression ISO Malathion results in decreased expression of PLEKHD1 mRNA CTD PMID:37047231 NCBI chr 6:100,340,655...100,371,942
Ensembl chr 6:100,340,655...100,371,941
JBrowse link
G Plin1 perilipin 1 increases expression ISO Malathion results in increased expression of PLIN1 mRNA CTD PMID:37047231 NCBI chr 1:133,664,294...133,676,854
Ensembl chr 1:133,664,892...133,676,828
JBrowse link
G Plin2 perilipin 2 increases expression ISO Malathion results in increased expression of PLIN2 mRNA CTD PMID:37047231 NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319
JBrowse link
G Plp1 proteolipid protein 1 decreases expression ISO Malathion results in decreased expression of PLP1 mRNA CTD PMID:37047231 NCBI chr  X:100,184,039...100,201,035
Ensembl chr  X:100,185,767...100,201,032
JBrowse link
G Pls3 plastin 3 increases expression ISO Malathion results in increased expression of PLS3 mRNA CTD PMID:37047231 NCBI chr  X:111,589,193...111,683,908
Ensembl chr  X:111,589,254...111,683,891
JBrowse link
G Plvap plasmalemma vesicle associated protein decreases expression ISO Malathion results in decreased expression of PLVAP mRNA CTD PMID:37047231 NCBI chr16:18,184,985...18,197,301
Ensembl chr16:18,184,975...18,197,301
JBrowse link
G Pml PML nuclear body scaffold decreases expression ISO Malathion results in decreased expression of PML mRNA CTD PMID:32069766 NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression ISO Malathion results in decreased expression of PPARA mRNA CTD PMID:25689681 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Prkd1 protein kinase D1 increases expression ISO Malathion results in increased expression of PRKD1 mRNA CTD PMID:32069766 NCBI chr 6:67,725,193...68,039,002
Ensembl chr 6:67,725,905...68,039,042
JBrowse link
G Prox2 prospero homeobox 2 decreases expression ISO Malathion results in decreased expression of PROX2 mRNA CTD PMID:37047231 NCBI chr 6:104,731,385...104,758,619
Ensembl chr 6:104,733,002...104,742,093
JBrowse link
G Proz protein Z, vitamin K-dependent plasma glycoprotein decreases expression ISO Malathion results in decreased expression of PROZ mRNA CTD PMID:37047231 NCBI chr16:76,450,013...76,463,558
Ensembl chr16:76,450,013...76,463,480
JBrowse link
G Ptcra pre T-cell antigen receptor alpha decreases expression ISO Malathion results in decreased expression of PTCRA mRNA CTD PMID:37047231 NCBI chr 9:14,218,907...14,229,141
Ensembl chr 9:14,218,802...14,229,235
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO Malathion results in increased expression of PTGS2 mRNA; Malathion results in increased expression of PTGS2 protein CTD PMID:30673264 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Pygl glycogen phosphorylase L multiple interactions
increases expression
EXP Acetylcysteine inhibits the reaction [Malathion results in increased expression of PYGL mRNA] CTD PMID:25449180 NCBI chr 6:88,697,598...88,740,260
Ensembl chr 6:88,697,593...88,740,310
JBrowse link
G Rab11fip3 RAB11 family interacting protein 3 increases expression ISO Malathion results in increased expression of RAB11FIP3 mRNA CTD PMID:32069766 NCBI chr10:15,002,650...15,086,382
Ensembl chr10:15,002,926...15,118,479
JBrowse link
G Rab3c RAB3C, member RAS oncogene family decreases expression ISO Malathion results in decreased expression of RAB3C mRNA CTD PMID:37047231 NCBI chr 2:41,627,720...41,843,541
Ensembl chr 2:41,627,720...41,843,749
JBrowse link
G Rapgef5 Rap guanine nucleotide exchange factor 5 increases expression ISO Malathion results in increased expression of RAPGEF5 mRNA CTD PMID:37047231 NCBI chr 6:138,445,184...138,679,943
Ensembl chr 6:138,437,991...138,679,936
JBrowse link
G Rbp3 retinol binding protein 3 decreases expression ISO Malathion results in decreased expression of RBP3 mRNA CTD PMID:37047231 NCBI chr16:9,267,538...9,276,006
Ensembl chr16:9,267,538...9,276,006
JBrowse link
G Rbp7 retinol binding protein 7 decreases expression ISO Malathion results in decreased expression of RBP7 mRNA CTD PMID:37047231 NCBI chr 5:159,889,723...159,894,338
Ensembl chr 5:159,889,723...159,894,339
JBrowse link
G Redic1 regulator of DNA class I crossover intermediates 1 decreases expression ISO Malathion results in decreased expression of REDIC1 mRNA CTD PMID:37047231 NCBI chr 7:122,318,495...122,386,002
Ensembl chr 7:122,318,499...122,385,983
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases expression
multiple interactions
EXP
ISO
Malathion results in increased expression of RELA mRNA
Taurine inhibits the reaction [Malathion results in increased expression of RELA mRNA]
CTD PMID:28987951 PMID:30673264 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Reln reelin increases expression ISO Malathion results in increased expression of RELN mRNA CTD PMID:37047231 NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211
JBrowse link
G Rfc3 replication factor C subunit 3 decreases expression ISO Malathion results in decreased expression of RFC3 mRNA CTD PMID:16079077 NCBI chr12:1,000,987...1,011,778
Ensembl chr12:1,000,994...1,011,778
JBrowse link
G Rft1 RFT1 homolog decreases expression ISO Malathion results in decreased expression of RFT1 mRNA CTD PMID:37047231 NCBI chr16:5,827,063...5,861,120
Ensembl chr16:5,827,088...5,861,120
JBrowse link
G Rhoa ras homolog family member A decreases activity ISO Malathion results in decreased activity of RHOA protein CTD PMID:37270087 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Rhox13 Rhox homeobox family member 13 increases expression ISO Malathion results in increased expression of RHOXF1 mRNA CTD PMID:37047231 NCBI chr  X:116,911,226...116,917,758
Ensembl chr  X:116,911,329...116,917,644
JBrowse link
G Rimbp2 RIMS binding protein 2 decreases expression ISO Malathion results in decreased expression of RIMBP2 mRNA CTD PMID:37047231 NCBI chr12:27,747,615...27,946,256
Ensembl chr12:27,747,980...27,956,763
JBrowse link
G Rnase6 ribonuclease A family member k6 increases expression EXP Malathion results in increased expression of RNASE6 mRNA CTD PMID:19784758 NCBI chr15:24,354,305...24,357,289
Ensembl chr15:24,354,303...24,357,328
JBrowse link
G Rnf170 ring finger protein 170 increases expression ISO Malathion results in increased expression of RNF170 mRNA CTD PMID:37047231 NCBI chr16:65,928,886...65,954,092
Ensembl chr16:65,928,895...65,954,083
JBrowse link
G Rnf183 ring finger protein 183 increases expression ISO Malathion results in increased expression of RNF183 mRNA CTD PMID:37047231 NCBI chr 5:75,877,111...75,886,253
Ensembl chr 5:75,876,003...75,886,191
JBrowse link
G Robo4 roundabout guidance receptor 4 decreases expression ISO Malathion results in decreased expression of ROBO4 mRNA CTD PMID:37047231 NCBI chr 8:37,119,953...37,133,887
Ensembl chr 8:37,119,988...37,132,519
JBrowse link
G Rph3a rabphilin 3A decreases expression ISO Malathion results in decreased expression of RPH3A mRNA CTD PMID:37047231 NCBI chr12:35,542,389...35,618,901
Ensembl chr12:35,542,728...35,617,592
JBrowse link
G Rrad RRAD, Ras related glycolysis inhibitor and calcium channel regulator increases expression ISO Malathion results in increased expression of RRAD mRNA CTD PMID:37047231 NCBI chr19:354,184...357,424
Ensembl chr19:354,198...357,417
JBrowse link
G Rs1 retinoschisin 1 increases expression ISO Malathion results in increased expression of RS1 mRNA CTD PMID:37047231 NCBI chr  X:33,962,440...33,992,203
Ensembl chr  X:33,963,657...33,992,115
JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 increases expression ISO Malathion results in increased expression of RSAD2 mRNA CTD PMID:37047231 NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699
JBrowse link
G Rspo2 R-spondin 2 decreases expression ISO Malathion results in decreased expression of RSPO2 mRNA CTD PMID:37047231 NCBI chr 7:74,096,378...74,239,398
Ensembl chr 7:74,103,090...74,238,933
JBrowse link
G RT1-A2 RT1 class Ia, locus A2 decreases expression ISO Malathion results in decreased expression of HLA-E mRNA CTD PMID:32069766 NCBI chr20:4,870,939...4,910,183 JBrowse link
G RT1-CE16 RT1 class I, locus CE16 decreases expression ISO Malathion results in decreased expression of HLA-A mRNA CTD PMID:32069766 NCBI chr20:3,257,109...3,260,747
Ensembl chr20:3,257,123...3,279,563
JBrowse link
G Runx1 RUNX family transcription factor 1 increases expression ISO Malathion results in increased expression of RUNX1 mRNA mutant form CTD PMID:28624474 NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542
JBrowse link
G S100a1 S100 calcium binding protein A1 decreases expression ISO Malathion results in decreased expression of S100A1 mRNA CTD PMID:37047231 NCBI chr 2:175,993,922...175,998,765
Ensembl chr 2:175,993,922...175,999,544
JBrowse link
G Scg5 secretogranin V increases expression ISO Malathion results in increased expression of SCG5 mRNA CTD PMID:37047231 NCBI chr 3:100,544,101...100,588,558
Ensembl chr 3:100,544,099...100,588,463
JBrowse link
G Scn9a sodium voltage-gated channel alpha subunit 9 decreases expression ISO Malathion results in decreased expression of SCN9A mRNA CTD PMID:37047231 NCBI chr 3:51,145,148...51,293,342
Ensembl chr 3:51,145,146...51,293,516
JBrowse link
G Serpinb2 serpin family B member 2 increases expression ISO Malathion results in increased expression of SERPINB2 mRNA CTD PMID:37047231 NCBI chr13:23,537,312...23,551,823
Ensembl chr13:23,541,400...23,550,408
JBrowse link
G Sftpb surfactant protein B decreases expression ISO Malathion results in decreased expression of SFTPB mRNA CTD PMID:37047231 NCBI chr 4:104,359,303...104,368,439
Ensembl chr 4:104,359,396...104,368,436
JBrowse link
G Sgpp2 sphingosine-1-phosphate phosphatase 2 increases expression ISO Malathion results in increased expression of SGPP2 mRNA CTD PMID:37047231 NCBI chr 9:79,762,658...79,884,665
Ensembl chr 9:79,763,284...79,880,457
JBrowse link
G Shc1 SHC adaptor protein 1 increases expression ISO Malathion results in increased expression of SHC1 mRNA CTD PMID:32069766 NCBI chr 2:174,837,937...174,849,538
Ensembl chr 2:174,837,930...174,849,536
JBrowse link
G Shisa3 shisa family member 3 increases expression ISO Malathion results in increased expression of SHISA3 mRNA CTD PMID:37047231 NCBI chr14:40,563,672...40,568,244
Ensembl chr14:40,563,673...40,568,244
JBrowse link
G Shisa9 shisa family member 9 increases expression ISO Malathion results in increased expression of SHISA9 mRNA CTD PMID:37047231 NCBI chr10:3,335,616...3,629,334
Ensembl chr10:3,337,979...3,627,773
JBrowse link
G Shtn1 shootin 1 decreases expression ISO Malathion results in decreased expression of SHTN1 mRNA CTD PMID:37047231 NCBI chr 1:258,121,966...258,225,861
Ensembl chr 1:258,121,968...258,228,265
JBrowse link
G Slc14a1 solute carrier family 14 member 1 (Kidd blood group) decreases expression ISO Malathion results in decreased expression of SLC14A1 mRNA CTD PMID:37047231 NCBI chr18:71,565,453...71,608,807
Ensembl chr18:71,565,454...71,595,146
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Malathion inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium] CTD PMID:23770354 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO Malathion inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:21561794 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
JBrowse link
G Slc4a5 solute carrier family 4 member 5 decreases expression ISO Malathion results in decreased expression of SLC4A5 mRNA CTD PMID:37047231 NCBI chr 4:115,710,101...115,810,330
Ensembl chr 4:115,725,592...115,810,323
JBrowse link
G Slco4a1 solute carrier organic anion transporter family, member 4a1 increases expression ISO Malathion results in increased expression of SLCO4A1 mRNA CTD PMID:37047231 NCBI chr 3:167,559,177...167,578,307
Ensembl chr 3:167,559,316...167,578,305
JBrowse link
G Smim32 small integral membrane protein 32 decreases expression ISO Malathion results in decreased expression of SMIM32 mRNA CTD PMID:37047231 NCBI chr17:7,853,492...7,857,235 JBrowse link
G Snca synuclein alpha increases expression
multiple interactions
EXP Malathion results in increased expression of SNCA mRNA; Malathion results in increased expression of SNCA protein
crocin inhibits the reaction [Malathion results in increased expression of SNCA mRNA]; crocin inhibits the reaction [Malathion results in increased expression of SNCA protein]; Levodopa inhibits the reaction [Malathion results in increased expression of SNCA mRNA]; Levodopa inhibits the reaction [Malathion results in increased expression of SNCA protein]
CTD PMID:35274200 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
JBrowse link
G Sntg1 syntrophin, gamma 1 decreases expression ISO Malathion results in decreased expression of SNTG1 mRNA CTD PMID:37047231 NCBI chr 5:9,980,550...10,794,666
Ensembl chr 5:9,981,115...10,791,181
JBrowse link
G Socs3 suppressor of cytokine signaling 3 decreases expression ISO Malathion results in decreased expression of SOCS3 mRNA CTD PMID:32069766 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
JBrowse link
G Sod1 superoxide dismutase 1 increases activity
decreases expression
multiple interactions
EXP
ISO
Malathion results in increased activity of SOD1 protein
Malathion results in decreased expression of SOD1 protein
lavender oil inhibits the reaction [Malathion results in decreased expression of SOD1 protein]
alpha-Tocopherol inhibits the reaction [Malathion results in increased activity of SOD1 protein]
CTD PMID:20194575 PMID:30409133 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions
decreases expression
EXP
ISO
alpha-Tocopherol inhibits the reaction [Malathion results in increased activity of SOD2 protein]; Malathion results in increased expression of and results in increased activity of SOD2 protein
lavender oil inhibits the reaction [Malathion results in decreased expression of SOD2 protein]
CTD PMID:20194575 PMID:30409133 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Spata17 spermatogenesis associated 17 decreases expression ISO Malathion results in decreased expression of SPATA17 mRNA CTD PMID:37047231 NCBI chr13:98,605,986...98,784,855
Ensembl chr13:98,605,986...98,784,929
JBrowse link
G Spdya speedy/RINGO cell cycle regulator family member A increases expression ISO Malathion results in increased expression of SPDYA mRNA CTD PMID:37047231 NCBI chr 6:23,905,574...23,954,926
Ensembl chr 6:23,910,223...23,954,850
JBrowse link
G Spink13 serine peptidase inhibitor Kazal type 13 decreases expression ISO Malathion results in decreased expression of SPINK13 mRNA CTD PMID:37047231 NCBI chr18:56,064,839...56,206,257
Ensembl chr18:56,064,839...56,206,257
JBrowse link
G Spink4 serine peptidase inhibitor, Kazal type 4 decreases expression ISO Malathion results in decreased expression of SPINK4 mRNA CTD PMID:37047231 NCBI chr 5:56,043,936...56,064,841
Ensembl chr 5:55,981,624...56,064,795
JBrowse link
G Srsf5 serine and arginine rich splicing factor 5 decreases expression EXP Malathion results in decreased expression of SRSF5 mRNA CTD PMID:19784758 NCBI chr 6:100,605,165...100,610,192
Ensembl chr 6:100,605,456...100,610,177
JBrowse link
G Sspo SCO-spondin decreases expression ISO Malathion results in decreased expression of SSPOP mRNA CTD PMID:37047231 NCBI chr 4:77,394,915...77,450,526
Ensembl chr 4:77,397,059...77,450,412
JBrowse link
G Sst somatostatin decreases expression ISO Malathion results in decreased expression of SST mRNA CTD PMID:37047231 NCBI chr11:76,956,896...76,958,173
Ensembl chr11:76,956,896...76,958,173
JBrowse link
G Sstr2 somatostatin receptor 2 increases expression ISO Malathion results in increased expression of SSTR2 mRNA CTD PMID:37047231 NCBI chr10:98,664,204...98,671,370
Ensembl chr10:98,664,216...98,674,351
JBrowse link
G St6gal2 ST6 beta-galactoside alpha-2,6-sialyltransferase 2 increases expression ISO Malathion results in increased expression of ST6GAL2 mRNA CTD PMID:37047231 NCBI chr 9:9,181,744...9,274,161
Ensembl chr 9:9,182,399...9,269,697
JBrowse link
G St8sia1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 increases expression EXP Malathion results in increased expression of ST8SIA1 mRNA CTD PMID:19784758 NCBI chr 4:175,782,989...175,921,338
Ensembl chr 4:175,789,947...175,920,708
JBrowse link
G St8sia4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 increases expression ISO Malathion results in increased expression of ST8SIA4 mRNA CTD PMID:37047231 NCBI chr 9:95,990,131...96,084,661
Ensembl chr 9:95,993,503...96,084,653
JBrowse link
G Star steroidogenic acute regulatory protein decreases expression
multiple interactions
ISO Malathion results in decreased expression of STAR mRNA
lavender oil inhibits the reaction [Malathion results in decreased expression of STAR mRNA]
CTD PMID:30409133 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation EXP Malathion results in decreased phosphorylation of STAT3 protein CTD PMID:34778934 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Stat5b signal transducer and activator of transcription 5B decreases activity ISO Malathion results in decreased activity of STAT5B protein CTD PMID:30114225 NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668
JBrowse link
G Stk36 serine/threonine kinase 36 decreases expression ISO Malathion results in decreased expression of STK36 mRNA CTD PMID:37047231 NCBI chr 9:76,176,922...76,204,423
Ensembl chr 9:76,176,920...76,204,422
JBrowse link
G Stra6 signaling receptor and transporter of retinol STRA6 decreases expression ISO Malathion results in decreased expression of STRA6 mRNA CTD PMID:37047231 NCBI chr 8:58,548,899...58,568,861
Ensembl chr 8:58,549,736...58,568,860
JBrowse link
G Tcf7l1 transcription factor 7 like 1 increases expression ISO Malathion results in increased expression of TCF7L1 mRNA CTD PMID:37047231 NCBI chr 4:104,680,734...104,846,086
Ensembl chr 4:104,680,739...104,845,287
JBrowse link
G Tchhl1 trichohyalin-like 1 decreases expression ISO Malathion results in decreased expression of TCHHL1 mRNA CTD PMID:37047231 NCBI chr 2:179,134,941...179,138,467
Ensembl chr 2:179,135,796...179,138,202
JBrowse link
G Tdrd1 tudor domain containing 1 increases expression ISO Malathion results in increased expression of TDRD1 mRNA CTD PMID:37047231 NCBI chr 1:255,871,939...255,919,222
Ensembl chr 1:255,875,887...255,915,871
JBrowse link
G Tdrd6 tudor domain containing 6 increases expression ISO Malathion results in increased expression of TDRD6 mRNA CTD PMID:37047231 NCBI chr 9:17,344,033...17,359,348
Ensembl chr 9:17,344,026...17,359,344
JBrowse link
G Tdrp testis development related protein decreases expression ISO Malathion results in decreased expression of TDRP mRNA CTD PMID:37047231 NCBI chr16:75,624,047...75,652,635
Ensembl chr16:75,624,907...75,652,420
JBrowse link
G Tek TEK receptor tyrosine kinase increases expression ISO Malathion results in increased expression of TEK mRNA CTD PMID:32069766 NCBI chr 5:109,607,077...109,733,805
Ensembl chr 5:109,607,077...109,733,804
JBrowse link
G Tet1 tet methylcytosine dioxygenase 1 affects expression EXP Malathion affects the expression of TET1 mRNA CTD PMID:36370973 NCBI chr20:25,761,042...25,840,926
Ensembl chr20:25,768,120...25,833,052
JBrowse link
G Tet2 tet methylcytosine dioxygenase 2 decreases expression EXP Malathion results in decreased expression of TET2 mRNA CTD PMID:36370973 NCBI chr 2:221,988,645...222,072,813
Ensembl chr 2:221,988,645...222,072,534
JBrowse link
G Tet3 tet methylcytosine dioxygenase 3 affects expression EXP Malathion affects the expression of TET3 mRNA CTD PMID:36370973 NCBI chr 4:115,867,412...115,964,433
Ensembl chr 4:115,871,265...115,964,193
JBrowse link
G Tfpi2 tissue factor pathway inhibitor 2 increases expression ISO Malathion results in increased expression of TFPI2 mRNA CTD PMID:37047231 NCBI chr 4:31,981,786...31,986,707
Ensembl chr 4:31,982,178...31,986,600
JBrowse link
G Tfrc transferrin receptor increases expression ISO Malathion results in increased expression of TFRC mRNA CTD PMID:32069766 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
JBrowse link
G Tg thyroglobulin decreases expression EXP Malathion results in decreased expression of TG mRNA; Malathion results in decreased expression of TG protein CTD PMID:29143548 NCBI chr 7:98,418,293...98,603,210
Ensembl chr 7:98,418,293...98,603,210
JBrowse link
G Tifab TIFA inhibitor decreases expression ISO Malathion results in decreased expression of TIFAB mRNA CTD PMID:37047231 NCBI chr17:8,433,406...8,436,541
Ensembl chr17:8,431,635...8,436,592
JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 decreases expression EXP Malathion results in decreased expression of TIMP3 mRNA CTD PMID:19784758 NCBI chr 7:17,520,827...17,571,850
Ensembl chr 7:17,521,919...17,571,839
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions
decreases expression
EXP [Malathion co-treated with Lead] results in decreased expression of TJP1 protein
Malathion results in decreased expression of TJP1 protein
CTD PMID:20970449 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
JBrowse link
G Tjp2 tight junction protein 2 multiple interactions
decreases expression
EXP [Malathion co-treated with Lead] results in decreased expression of TJP2 protein
Malathion results in decreased expression of TJP2 protein
CTD PMID:20970449 NCBI chr 1:221,709,745...221,838,291
Ensembl chr 1:221,709,745...221,838,295
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions
increases expression
ISO Plant Extracts inhibits the reaction [Malathion results in increased expression of TLR4 protein]; Polyphenols inhibits the reaction [Malathion results in increased expression of TLR4 protein] CTD PMID:32120800 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tlr8 toll-like receptor 8 increases expression ISO Malathion results in increased expression of TLR8 mRNA CTD PMID:32069766 NCBI chr  X:27,091,780...27,116,092
Ensembl chr  X:27,091,778...27,116,549
JBrowse link
G Tmem114 transmembrane protein 114 decreases expression ISO Malathion results in decreased expression of TMEM114 mRNA CTD PMID:37047231 NCBI chr10:7,168,998...7,185,251
Ensembl chr10:7,169,746...7,185,251
JBrowse link
G Tmem158 transmembrane protein 158 increases expression ISO Malathion results in increased expression of TMEM158 mRNA CTD PMID:37047231 NCBI chr 8:122,913,675...122,914,673
Ensembl chr 8:122,913,675...122,914,673
JBrowse link
G Tmem241 transmembrane protein 241 decreases expression ISO Malathion results in decreased expression of TMEM241 mRNA CTD PMID:37047231 NCBI chr18:3,168,072...3,318,340
Ensembl chr18:3,168,067...3,318,293
JBrowse link
G Tmem65 transmembrane protein 65 increases expression ISO Malathion results in increased expression of TMEM65 mRNA CTD PMID:37047231 NCBI chr 7:90,336,997...90,378,930
Ensembl chr 7:90,274,142...90,379,474
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
EXP
ISO
Malathion results in increased expression of TNF mRNA
Taurine inhibits the reaction [Malathion results in increased expression of TNF mRNA]
CTD PMID:28987951 PMID:37047231 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfaip6 TNF alpha induced protein 6 increases expression ISO Malathion results in increased expression of TNFAIP6 mRNA CTD PMID:37047231 NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649
JBrowse link
G Tnfaip8l3 TNF alpha induced protein 8 like 3 decreases expression ISO Malathion results in decreased expression of TNFAIP8L3 mRNA CTD PMID:37047231 NCBI chr 8:54,413,503...54,455,512
Ensembl chr 8:54,414,457...54,500,079
JBrowse link
G Tnfsf15 TNF superfamily member 15 affects expression ISO Malathion affects the expression of TNFSF15 mRNA CTD PMID:37047231 NCBI chr 5:77,134,885...77,156,171
Ensembl chr 5:77,139,878...77,156,228
JBrowse link
G Tnip3 TNFAIP3 interacting protein 3 increases expression ISO Malathion results in increased expression of TNIP3 mRNA CTD PMID:37047231 NCBI chr 4:94,867,258...94,908,780
Ensembl chr 4:94,811,097...94,907,605
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO
EXP
Atropine inhibits the reaction [Malathion results in increased expression of TP53 protein]
Plant Extracts inhibits the reaction [Malathion results in increased expression of TRP53 protein]; Polyphenols inhibits the reaction [Malathion results in increased expression of TRP53 protein]
[Vitamin E co-treated with Selenium] inhibits the reaction [Malathion results in increased expression of TP53 mRNA]
Malathion results in increased expression of TP53 mRNA; Malathion results in increased expression of TP53 protein
CTD PMID:12505448 PMID:12762645 PMID:18204794 PMID:19787260 PMID:21628957 More... NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tp53i3 tumor protein p53 inducible protein 3 increases expression
multiple interactions
ISO Malathion results in increased expression of TP53I3 mRNA
[Malathion co-treated with Estrogens] results in increased expression of TP53I3 mRNA
CTD PMID:18204794 NCBI chr 6:27,818,327...27,825,753 JBrowse link
G Tpd52l3 TPD52 like 3 decreases expression ISO Malathion results in decreased expression of TPD52L3 mRNA CTD PMID:37047231 NCBI chr 1:227,781,173...227,785,040
Ensembl chr 1:227,773,724...227,784,467
JBrowse link
G Tpr translocated promoter region, nuclear basket protein increases expression ISO Malathion results in increased expression of TPR mRNA CTD PMID:32069766 NCBI chr13:62,424,312...62,487,502
Ensembl chr13:62,424,312...62,487,496
JBrowse link
G Tram1l1 translocation associated membrane protein 1-like 1 increases expression ISO Malathion results in increased expression of TRAM1L1 mRNA CTD PMID:37047231 NCBI chr 2:212,511,130...212,513,311 JBrowse link
G Trim35 tripartite motif-containing 35 decreases expression ISO Malathion results in decreased expression of TRIM35 mRNA CTD PMID:32069766 NCBI chr15:40,493,697...40,510,246
Ensembl chr15:40,493,755...40,510,240
JBrowse link
G Trpc1 transient receptor potential cation channel, subfamily C, member 1 increases expression EXP Malathion results in increased expression of TRPC1 mRNA; Malathion results in increased expression of TRPC1 protein CTD PMID:22674931 NCBI chr 8:96,263,322...96,314,220
Ensembl chr 8:96,263,329...96,314,276
JBrowse link
G Trpc4 transient receptor potential cation channel, subfamily C, member 4 increases expression
decreases expression
EXP
ISO
Malathion results in increased expression of TRPC4 mRNA; Malathion results in increased expression of TRPC4 protein
Malathion results in decreased expression of TRPC4 mRNA
CTD PMID:22674931 PMID:37047231 NCBI chr 2:138,307,676...138,476,856
Ensembl chr 2:138,308,084...138,476,768
JBrowse link
G Trpc5os TRPC5 opposite strand increases expression ISO Malathion results in increased expression of TRPC5OS mRNA CTD PMID:37047231 NCBI chr  X:108,025,172...108,044,201
Ensembl chr  X:108,024,924...108,046,581
JBrowse link
G Tshr thyroid stimulating hormone receptor decreases expression EXP Malathion results in decreased expression of TSHR protein CTD PMID:29143548 NCBI chr 6:110,341,585...110,475,297
Ensembl chr 6:110,341,581...110,474,538
JBrowse link
G Ttc9 tetratricopeptide repeat domain 9 decreases expression ISO Malathion results in decreased expression of TTC9 mRNA CTD PMID:37047231 NCBI chr 6:101,333,274...101,368,110
Ensembl chr 6:101,333,141...101,368,110
JBrowse link
G Tusc2 tumor suppressor 2, mitochondrial calcium regulator decreases expression ISO Malathion results in decreased expression of TUSC2 mRNA CTD PMID:32069766 NCBI chr 8:108,236,838...108,240,056
Ensembl chr 8:108,236,838...108,240,056
JBrowse link
G Twist1 twist family bHLH transcription factor 1 increases expression ISO Malathion results in increased expression of TWIST1 mRNA CTD PMID:32069766 NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653
JBrowse link
G Txnrd3 thioredoxin reductase 3 decreases expression ISO Malathion results in decreased expression of TXNRD3 mRNA CTD PMID:37047231 NCBI chr 4:122,072,548...122,112,493
Ensembl chr 4:122,072,548...122,112,491
JBrowse link
G Tyms thymidylate synthetase decreases expression ISO Malathion results in decreased expression of TYMS mRNA CTD PMID:16079077 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536
JBrowse link
G Ubd ubiquitin D increases expression ISO Malathion results in increased expression of UBD mRNA CTD PMID:37047231 NCBI chr20:1,385,487...1,387,438
Ensembl chr20:1,385,864...1,408,639
Ensembl chr20:1,385,864...1,408,639
JBrowse link
G Umodl1 uromodulin-like 1 increases expression ISO Malathion results in increased expression of UMODL1 mRNA CTD PMID:37047231 NCBI chr20:9,027,751...9,087,133
Ensembl chr20:9,025,724...9,087,146
JBrowse link
G Usp2 ubiquitin specific peptidase 2 increases expression ISO Malathion results in increased expression of USP2 mRNA CTD PMID:37047231 NCBI chr 8:44,411,457...44,439,668
Ensembl chr 8:44,411,607...44,438,331
JBrowse link
G Usp27x ubiquitin specific peptidase 27, X-linked increases expression ISO Malathion results in increased expression of USP27X mRNA CTD PMID:37047231 NCBI chr  X:15,123,620...15,126,855
Ensembl chr  X:15,124,596...15,125,912
JBrowse link
G Vhl von Hippel-Lindau tumor suppressor decreases expression ISO Malathion results in decreased expression of VHL mRNA CTD PMID:32069766 NCBI chr 4:146,772,483...146,779,376
Ensembl chr 4:146,772,468...146,779,377
JBrowse link
G Vpreb3 V-set pre-B cell surrogate light chain 3 increases expression ISO Malathion results in increased expression of VPREB3 mRNA CTD PMID:32069766 NCBI chr20:12,717,421...12,718,785
Ensembl chr20:12,716,779...12,719,520
JBrowse link
G Wbp2nl WBP2 N-terminal like decreases expression ISO Malathion results in decreased expression of WBP2NL mRNA CTD PMID:37047231 NCBI chr 7:113,814,793...113,831,974
Ensembl chr 7:113,814,992...113,831,333
JBrowse link
G Wfdc6a WAP four-disulfide core domain 6A decreases expression ISO Malathion results in decreased expression of WFDC6 mRNA CTD PMID:37047231 NCBI chr 3:153,305,336...153,309,144
Ensembl chr 3:153,305,336...153,309,144
JBrowse link
G Wipf3 WAS/WASL interacting protein family, member 3 decreases expression ISO Malathion results in decreased expression of WIPF3 mRNA CTD PMID:37047231 NCBI chr 4:83,550,075...83,629,929
Ensembl chr 4:83,550,468...83,629,386
JBrowse link
G Wt1 WT1 transcription factor increases expression ISO Malathion results in increased expression of WT1 mRNA CTD PMID:32069766 NCBI chr 3:91,566,540...91,613,653
Ensembl chr 3:91,567,001...91,613,643
JBrowse link
G Xkr4 XK related 4 decreases expression ISO Malathion results in decreased expression of XKR4 mRNA CTD PMID:37047231 NCBI chr 5:15,896,818...16,297,733
Ensembl chr 5:15,895,863...16,282,962
JBrowse link
G Zfp42 zinc finger protein 42 decreases expression ISO Malathion results in decreased expression of ZFP42 mRNA CTD PMID:37047231 NCBI chr16:48,836,463...48,845,443
Ensembl chr16:48,836,648...48,845,401
JBrowse link
G Zfpm2 zinc finger protein, multitype 2 increases expression ISO Malathion results in increased expression of ZFPM2 mRNA CTD PMID:37047231 NCBI chr 7:71,678,658...72,116,209
Ensembl chr 7:71,678,880...72,116,205
JBrowse link
G Zscan5b zinc finger and SCAN domain containing 5B decreases expression ISO Malathion results in decreased expression of ZSCAN5B mRNA CTD PMID:37047231 NCBI chr 1:67,666,684...67,674,238
Ensembl chr 1:67,666,691...67,674,238
JBrowse link
malic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO [Glutamic Acid co-treated with malic acid co-treated with Ubiquinone] inhibits the reaction [chromium hexavalent ion results in increased activity of CASP3 protein]; [Glutamic Acid co-treated with malic acid] inhibits the reaction [chromium hexavalent ion results in increased activity of CASP3 protein] CTD PMID:24732427 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions
decreases abundance
ISO Triazines inhibits the reaction [IDH2 protein mutant form results in decreased abundance of malic acid] CTD PMID:27469509 NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
JBrowse link
G Mdh1 malate dehydrogenase 1 increases expression ISO malic acid deficiency results in increased expression of MDH1 mRNA CTD PMID:26811028 NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO [[NR1H4 protein co-treated with Dietary Fats] results in increased susceptibility to caffeic acid phenethyl ester] which results in increased abundance of malic acid CTD PMID:28223344 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO malic acid results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
methylprednisolone succinate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ces2h carboxylesterase 2H multiple interactions
increases hydrolysis
EXP Dexamethasone promotes the reaction [CES2 protein results in increased hydrolysis of Methylprednisolone Hemisuccinate] CTD PMID:15794950 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
JBrowse link
misoprostol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adcyap1 adenylate cyclase activating polypeptide 1 multiple interactions EXP Misoprostol inhibits the reaction [ADCYAP1 protein results in increased secretion of Histamine] CTD PMID:11164953 NCBI chr 9:113,102,632...113,122,500
Ensembl chr 9:113,103,718...113,109,773
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Misoprostol inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein] CTD PMID:18602972 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Casp3 caspase 3 multiple interactions EXP Misoprostol inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein] CTD PMID:18602972 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase multiple interactions EXP Misoprostol inhibits the reaction [Cisplatin results in decreased expression of CAT protein] CTD PMID:21458517 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions EXP Misoprostol inhibits the reaction [(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride binds to and results in increased activity of CHRM1 protein] CTD PMID:2459756 NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356
JBrowse link
G Gast gastrin multiple interactions
decreases activity
EXP Misoprostol inhibits the reaction [GAST protein results in increased secretion of Histamine]
Misoprostol results in decreased activity of GAST protein
CTD PMID:2459756 PMID:11164953 NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Misoprostol inhibits the reaction [[IL23A co-treated with IL1B] results in increased expression of IL10] CTD PMID:19273625 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Misoprostol inhibits the reaction [[IL23A co-treated with IL1B] results in increased expression of IL10] CTD PMID:19273625 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il23a interleukin 23 subunit alpha multiple interactions
increases expression
ISO Misoprostol inhibits the reaction [[IL23A co-treated with IL1B] results in increased expression of IL10]
Misoprostol results in increased expression of IL23A mRNA
CTD PMID:19273625 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
JBrowse link
G Ptger1 prostaglandin E receptor 1 multiple interactions ISO [L-335677 binds to and results in decreased activity of PTGER1 protein] inhibits the reaction [Misoprostol results in increased susceptibility to Formaldehyde] CTD PMID:16360148 NCBI chr19:24,470,258...24,473,687
Ensembl chr19:24,467,532...24,473,559
JBrowse link
G Ptger2 prostaglandin E receptor 2 multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid binds to and results in decreased activity of PTGER2 protein] inhibits the reaction [Misoprostol results in increased susceptibility to Formaldehyde] CTD PMID:16360148 NCBI chr15:18,215,013...18,228,714
Ensembl chr15:18,217,285...18,228,714
JBrowse link
G Ptger3 prostaglandin E receptor 3 multiple interactions ISO [L-826266 binds to and results in decreased activity of PTGER3 protein] inhibits the reaction [Misoprostol results in decreased susceptibility to Formaldehyde] CTD PMID:16360148 NCBI chr 2:246,606,131...246,750,970
Ensembl chr 2:246,606,183...246,684,434
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
EXP 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide inhibits the reaction [Misoprostol results in increased expression of PTGS2 protein]; Indomethacin inhibits the reaction [Misoprostol results in increased expression of PTGS2 protein] CTD PMID:12428691 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Tac1 tachykinin, precursor 1 multiple interactions EXP Misoprostol promotes the reaction [Kallidin results in increased secretion of TAC1 protein] CTD PMID:16039053 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Misoprostol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF] CTD PMID:9298541 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
monomethyl succinate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO [alpha-ketoisocaproic acid co-treated with monomethyl succinate] inhibits the reaction [Palmitates results in decreased expression of SLC2A4 mRNA] CTD PMID:21802492 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO monomethyl succinate inhibits the reaction [bis((2-oxindol-3-ylimino)-2-(2-aminoethyl)pyridine-N,N')copper(II) results in increased expression of TP53 protein] CTD PMID:21548882 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
nizatidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calca calcitonin-related polypeptide alpha increases expression ISO Nizatidine results in increased expression of CALCA protein CTD PMID:12495560 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Tac1 tachykinin, precursor 1 increases expression ISO Nizatidine results in increased expression of TAC1 protein CTD PMID:12495560 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
JBrowse link
omeprazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO Omeprazole results in increased expression of ABCA1 mRNA CTD PMID:20060385 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Omeprazole results in decreased activity of ABCB11 protein CTD PMID:20829430 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects expression
multiple interactions
EXP
ISO
Omeprazole affects the expression of ABCB1A mRNA
Omeprazole promotes the reaction [Cisplatin results in increased expression of ABCB1 protein]
Omeprazole promotes the reaction [Cisplatin results in increased expression of ABCB1A protein]
CTD PMID:19483382 PMID:30452898 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 decreases expression ISO Omeprazole results in decreased expression of ABCB4 mRNA CTD PMID:12040753 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO [Omeprazole results in increased susceptibility to Cisplatin] which results in decreased expression of ABCC2 protein CTD PMID:35447140 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP Omeprazole results in increased expression of ABCC3 mRNA CTD PMID:19118567 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcc6 ATP binding cassette subfamily C member 6 affects expression EXP Omeprazole affects the expression of ABCC6 mRNA CTD PMID:19483382 NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases expression
multiple interactions
ISO Omeprazole results in increased expression of ABCG2 mRNA alternative form; Omeprazole results in increased expression of ABCG2 protein
Omeprazole inhibits the reaction [ABCG2 protein results in increased transport of lucifer yellow]
CTD PMID:20804740 PMID:31348918 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 affects expression EXP Omeprazole affects the expression of ABCG5 mRNA CTD PMID:19483382 NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563
JBrowse link
G Abhd1 abhydrolase domain containing 1 affects expression EXP Omeprazole affects the expression of ABHD1 mRNA CTD PMID:19483382 NCBI chr 6:25,422,526...25,427,514
Ensembl chr 6:25,422,526...25,427,514
JBrowse link
G Abhd14b abhydrolase domain containing 14b affects expression EXP Omeprazole affects the expression of ABHD14B mRNA CTD PMID:19483382 NCBI chr 8:107,087,157...107,092,122
Ensembl chr 8:107,088,069...107,092,119
JBrowse link
G Abhd17a abhydrolase domain containing 17A, depalmitoylase affects expression EXP Omeprazole affects the expression of ABHD17A mRNA CTD PMID:19483382 NCBI chr 7:9,124,332...9,132,762
Ensembl chr 7:9,124,332...9,130,762
JBrowse link
G Acaca acetyl-CoA carboxylase alpha affects expression EXP Omeprazole affects the expression of ACACA mRNA CTD PMID:19483382 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Acadl acyl-CoA dehydrogenase, long chain affects expression EXP Omeprazole affects the expression of ACADL mRNA CTD PMID:19483382 NCBI chr 9:68,333,981...68,372,149
Ensembl chr 9:68,333,980...68,372,220
JBrowse link
G Ace2 angiotensin converting enzyme 2 decreases expression EXP
ISO
Omeprazole results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Aco1 aconitase 1 affects expression EXP Omeprazole affects the expression of ACO1 mRNA CTD PMID:19483382 NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391
JBrowse link
G Aco2 aconitase 2 affects expression EXP Omeprazole affects the expression of ACO2 mRNA CTD PMID:19483382 NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261
JBrowse link
G Acot12 acyl-CoA thioesterase 12 affects expression EXP Omeprazole affects the expression of ACOT12 mRNA CTD PMID:19483382 NCBI chr 2:22,986,867...23,027,538
Ensembl chr 2:22,986,626...23,027,536
JBrowse link
G Acot4 acyl-CoA thioesterase 4 affects expression EXP Omeprazole affects the expression of ACOT4 mRNA CTD PMID:19483382 NCBI chr 6:103,668,699...103,674,037
Ensembl chr 6:103,668,753...103,673,917
JBrowse link
G Adam15 ADAM metallopeptidase domain 15 affects expression EXP Omeprazole affects the expression of ADAM15 mRNA CTD PMID:19483382 NCBI chr 2:174,754,629...174,765,136
Ensembl chr 2:174,754,633...174,765,113
JBrowse link
G Add1 adducin 1 affects expression EXP Omeprazole affects the expression of ADD1 mRNA CTD PMID:19483382 NCBI chr14:76,108,643...76,167,267
Ensembl chr14:76,108,654...76,167,182
JBrowse link
G Adh1c alcohol dehydrogenase 1C (class I), gamma polypeptide decreases expression ISO Omeprazole results in decreased expression of ADH1C mRNA CTD PMID:12040753 NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892
JBrowse link
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide affects expression EXP Omeprazole affects the expression of ADH4 mRNA CTD PMID:19483382 NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591
JBrowse link
G Adtrp androgen-dependent TFPI-regulating protein affects expression EXP Omeprazole affects the expression of ADTRP mRNA CTD PMID:19483382 NCBI chr17:22,907,758...22,993,834
Ensembl chr17:22,930,740...22,993,826
JBrowse link
G Afm afamin affects expression EXP Omeprazole affects the expression of AFM mRNA CTD PMID:19483382 NCBI chr14:17,531,022...17,563,868
Ensembl chr14:17,531,024...17,563,870
JBrowse link
G Agt angiotensinogen affects expression EXP Omeprazole affects the expression of AGT mRNA CTD PMID:19483382 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Agtr1a angiotensin II receptor, type 1a affects expression EXP Omeprazole affects the expression of AGTR1A mRNA CTD PMID:19483382 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
decreases activity
increases activity
increases expression
decreases expression
affects localization
increases response to substance
ISO
EXP
AG-879 inhibits the reaction [Omeprazole results in increased activity of AHR protein]; AHR protein affects the reaction [Omeprazole results in decreased expression of CXCR4 mRNA]; AHR protein affects the reaction [Omeprazole results in increased expression of HAMP mRNA]; AHR protein affects the susceptibility to [Omeprazole results in increased expression of CYP1A1 mRNA]; AHR protein affects the susceptibility to [Omeprazole results in increased expression of CYP1A2 mRNA]; AHR protein mutant form inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; AHR protein promotes the reaction [Omeprazole results in decreased expression of AHR mRNA]; AHR protein promotes the reaction [Omeprazole results in decreased expression of CYP1A1 mRNA]; BMX mRNA affects the reaction [Omeprazole results in increased activity of AHR protein]; Omeprazole binds to and results in increased activity of AHR protein; Omeprazole promotes the reaction [AHR protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [AHR protein binds to CYP1B1 promoter]; omeprazole sulfide inhibits the reaction [Omeprazole results in increased activity of AHR protein]; Puromycin inhibits the reaction [Omeprazole results in increased expression of AHR protein]
Omeprazole results in decreased activity of AHR protein
Omeprazole affects the localization of AHR protein
AHR protein results in increased susceptibility to Omeprazole
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of AHR mRNA; AHR protein promotes the reaction [Omeprazole results in increased expression of CYP1A1 protein]; Omeprazole affects the localization of [ARNT protein co-treated with AHR protein]
CTD PMID:9139728 PMID:9395520 PMID:14742684 PMID:16109480 PMID:20171196 More... NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 affects expression EXP Omeprazole affects the expression of AKR1A1 mRNA CTD PMID:19483382 NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674
JBrowse link
G Akr7a2 aldo-keto reductase family 7, member A2 affects expression EXP Omeprazole affects the expression of AKR7A2 mRNA CTD PMID:19483382 NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909
JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 affects expression
multiple interactions
EXP Omeprazole affects the expression of AKR7A3 mRNA
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of AKR7A3 mRNA
CTD PMID:19483382 PMID:22687989 NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 affects expression
multiple interactions
EXP Omeprazole affects the expression of ALDH1A1 mRNA
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of ALDH1A1 mRNA
CTD PMID:19483382 PMID:22687989 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 increases expression ISO Omeprazole results in increased expression of ALDH1A3 mRNA CTD PMID:12040753 NCBI chr 1:119,982,272...120,017,416
Ensembl chr 1:119,982,277...120,017,436
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member affects expression EXP Omeprazole affects the expression of ALDH2 mRNA CTD PMID:19483382 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521
JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 increases expression ISO Omeprazole results in increased expression of ALDH3A1 mRNA CTD PMID:12040753 NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681
JBrowse link
G Alkbh7 alkB homolog 7 affects expression EXP Omeprazole affects the expression of ALKBH7 mRNA CTD PMID:19483382 NCBI chr 9:1,838,886...1,841,044
Ensembl chr 9:1,838,811...1,841,044
JBrowse link
G Ankrd40 ankyrin repeat domain 40 increases expression EXP Omeprazole results in increased expression of TMPRSS2 mRNA CTD PMID:32808185 NCBI chr10:79,282,075...79,295,322
Ensembl chr10:79,282,075...79,295,320
JBrowse link
G Ap2m1 adaptor related protein complex 2 subunit mu 1 affects expression EXP Omeprazole affects the expression of AP2M1 mRNA CTD PMID:19483382 NCBI chr11:80,355,307...80,364,218
Ensembl chr11:80,328,041...80,364,140
JBrowse link
G Apcs amyloid P component, serum affects expression EXP Omeprazole affects the expression of APCS mRNA CTD PMID:19483382 NCBI chr13:85,373,219...85,374,195
Ensembl chr13:85,373,220...85,374,298
JBrowse link
G Apoa4 apolipoprotein A4 affects expression EXP Omeprazole affects the expression of APOA4 mRNA CTD PMID:19483382 NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469
JBrowse link
G Apoh apolipoprotein H affects expression EXP Omeprazole affects the expression of APOH mRNA CTD PMID:19483382 NCBI chr10:93,342,435...93,356,334
Ensembl chr10:93,310,977...93,356,329
JBrowse link
G Apool apolipoprotein O-like affects expression EXP Omeprazole affects the expression of APOOL mRNA CTD PMID:19483382 NCBI chr  X:77,377,723...77,443,672
Ensembl chr  X:77,377,781...77,443,900
JBrowse link
G Arg1 arginase 1 affects expression EXP Omeprazole affects the expression of ARG1 mRNA CTD PMID:19483382 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
JBrowse link
G Arl6ip1 ADP-ribosylation factor like GTPase 6 interacting protein 1 affects expression EXP Omeprazole affects the expression of ARL6IP1 mRNA CTD PMID:19483382 NCBI chr 1:172,430,475...172,439,990
Ensembl chr 1:172,430,489...172,439,994
JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions
affects localization
ISO
EXP
Omeprazole promotes the reaction [ARNT protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [ARNT protein binds to CYP1B1 promoter]
Omeprazole affects the localization of ARNT protein
Omeprazole affects the localization of [ARNT protein co-treated with AHR protein]
CTD PMID:9395520 PMID:21703235 PMID:25826687 NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
JBrowse link
G Asgr2 asialoglycoprotein receptor 2 affects expression EXP Omeprazole affects the expression of ASGR2 mRNA CTD PMID:19483382 NCBI chr10:54,821,407...54,834,624
Ensembl chr10:54,821,438...54,834,617
JBrowse link
G Atf5 activating transcription factor 5 affects expression EXP Omeprazole affects the expression of ATF5 mRNA CTD PMID:19483382 NCBI chr 1:95,295,602...95,299,755
Ensembl chr 1:95,295,610...95,299,707
JBrowse link
G Atp5f1e ATP synthase F1 subunit epsilon affects expression EXP Omeprazole affects the expression of ATP5F1E mRNA CTD PMID:19483382 NCBI chr 3:163,259,072...163,261,974
Ensembl chr 3:163,260,476...163,261,450
JBrowse link
G Atp6ap2 ATPase H+ transporting accessory protein 2 affects expression EXP Omeprazole affects the expression of ATP6AP2 mRNA CTD PMID:19483382 NCBI chr  X:10,183,983...10,210,948
Ensembl chr  X:10,183,068...10,210,918
JBrowse link
G Atp6v1a ATPase H+ transporting V1 subunit A affects expression EXP Omeprazole affects the expression of ATP6V1A mRNA CTD PMID:19483382 NCBI chr11:56,561,444...56,614,694
Ensembl chr11:56,560,974...56,614,694
JBrowse link
G Atp6v1f ATPase H+ transporting V1 subunit F affects expression EXP Omeprazole affects the expression of ATP6V1F mRNA CTD PMID:19483382 NCBI chr 4:58,067,666...58,070,628 JBrowse link
G Atp7a ATPase copper transporting alpha multiple interactions ISO Omeprazole inhibits the reaction [ATP7A protein results in increased activity of TYR protein]
Omeprazole inhibits the reaction [Copper affects the localization of ATP7A protein]; Omeprazole inhibits the reaction [cupric chloride affects the localization of ATP7A protein]
CTD PMID:25337692 NCBI chr  X:71,094,144...71,201,550
Ensembl chr  X:71,094,202...71,198,354
JBrowse link
G Baat bile acid CoA:amino acid N-acyltransferase affects expression EXP Omeprazole affects the expression of BAAT mRNA CTD PMID:19483382 NCBI chr 5:63,851,668...63,860,641
Ensembl chr 5:63,850,705...63,860,685
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Omeprazole inhibits the reaction [Cisplatin results in increased expression of BAX protein] CTD PMID:30452898 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO Omeprazole inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein] CTD PMID:30452898 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl6b BCL6B, transcription repressor affects expression EXP Omeprazole affects the expression of BCL6B mRNA CTD PMID:19483382 NCBI chr10:54,940,908...54,947,022
Ensembl chr10:54,940,909...54,945,974
JBrowse link
G Bltp3b bridge-like lipid transfer protein family member 3B affects expression EXP Omeprazole affects the expression of BLTP3B mRNA CTD PMID:19483382 NCBI chr 7:24,181,635...24,261,720
Ensembl chr 7:24,181,644...24,261,720
JBrowse link
G Bmf Bcl2 modifying factor affects expression EXP Omeprazole affects the expression of BMF mRNA CTD PMID:19483382 NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145
JBrowse link
G Bmx BMX non-receptor tyrosine kinase multiple interactions ISO BMX mRNA affects the reaction [Omeprazole results in increased activity of AHR protein] CTD PMID:21861773 NCBI chr  X:30,227,251...30,290,015
Ensembl chr  X:30,227,251...30,289,993
JBrowse link
G Bnip3 BCL2 interacting protein 3 affects expression EXP Omeprazole affects the expression of BNIP3 mRNA CTD PMID:19483382 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
JBrowse link
G Btf3 basic transcription factor 3 affects expression EXP Omeprazole affects the expression of BTF3 mRNA CTD PMID:19483382 NCBI chr 2:29,659,764...29,666,898
Ensembl chr 2:29,659,231...29,666,879
JBrowse link
G C1qa complement C1q A chain decreases expression EXP Omeprazole results in decreased expression of C1QA mRNA CTD PMID:25626140 NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534
JBrowse link
G C1qbp complement C1q binding protein affects expression EXP Omeprazole affects the expression of C1QBP mRNA CTD PMID:19483382 NCBI chr10:55,699,954...55,704,605
Ensembl chr10:55,699,954...55,704,649
JBrowse link
G C1qc complement C1q C chain decreases expression EXP Omeprazole results in decreased expression of C1QC mRNA CTD PMID:25626140 NCBI chr 5:149,127,412...149,130,757
Ensembl chr 5:149,127,415...149,131,017
JBrowse link
G C1s complement C1s affects expression EXP Omeprazole affects the expression of C1S mRNA CTD PMID:19483382 NCBI chr 4:157,430,249...157,442,438
Ensembl chr 4:157,430,117...157,442,303
JBrowse link
G C2cd2 C2 calcium-dependent domain containing 2 affects expression EXP Omeprazole affects the expression of C2CD2 mRNA CTD PMID:19483382 NCBI chr11:37,225,321...37,289,741
Ensembl chr11:37,227,415...37,289,739
JBrowse link
G C4bpa complement component 4 binding protein, alpha affects expression
decreases expression
EXP Omeprazole affects the expression of C4BPA mRNA
Omeprazole results in decreased expression of C4BPA mRNA
CTD PMID:19483382 PMID:25626140 NCBI chr13:42,075,715...42,111,205
Ensembl chr13:42,075,717...42,111,205
JBrowse link
G C4bpb complement component 4 binding protein, beta decreases expression EXP Omeprazole results in decreased expression of C4BPB mRNA CTD PMID:25626140 NCBI chr13:42,120,798...42,131,515
Ensembl chr13:42,120,798...42,131,817
JBrowse link
G C7 complement C7 affects expression EXP Omeprazole affects the expression of C7 mRNA CTD PMID:19483382 NCBI chr 2:54,088,116...54,165,102
Ensembl chr 2:54,088,116...54,158,535
JBrowse link
G C8b complement C8 beta chain affects expression EXP Omeprazole affects the expression of C8B mRNA CTD PMID:19483382 NCBI chr 5:119,535,009...119,572,565
Ensembl chr 5:119,535,146...119,572,565
JBrowse link
G Cadps2 calcium dependent secretion activator 2 affects expression EXP Omeprazole affects the expression of CADPS2 mRNA CTD PMID:19483382 NCBI chr 4:51,780,415...52,309,641
Ensembl chr 4:51,781,053...52,309,829
JBrowse link
G Caprin1 cell cycle associated protein 1 affects expression EXP Omeprazole affects the expression of CAPRIN1 mRNA CTD PMID:19483382 NCBI chr 3:90,152,305...90,230,447
Ensembl chr 3:90,153,620...90,230,502
JBrowse link
G Car2 carbonic anhydrase 2 affects expression EXP Omeprazole affects the expression of CA2 mRNA CTD PMID:19483382 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
JBrowse link
G Car3 carbonic anhydrase 3 affects expression EXP Omeprazole affects the expression of CAR3 mRNA CTD PMID:19483382 NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
affects expression
increases cleavage
ISO
EXP
Omeprazole analog results in increased activity of CASP3 protein; Omeprazole results in increased activity of CASP3 protein
Omeprazole inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]
Omeprazole inhibits the reaction [Ethanol results in increased activity of CASP3 protein]; Omeprazole inhibits the reaction [Ethanol results in increased expression of CASP3 mRNA]; Omeprazole inhibits the reaction [Indomethacin results in increased activity of CASP3 protein]
Omeprazole affects the expression of CASP3 mRNA
Omeprazole results in increased cleavage of CASP3 protein
CTD PMID:15461867 PMID:18336733 PMID:19251492 PMID:19483382 PMID:25637687 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases cleavage ISO Omeprazole analog results in increased cleavage of CASP8 protein CTD PMID:18336733 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Cat catalase increases activity
multiple interactions
EXP
ISO
Omeprazole results in increased activity of CAT protein
Omeprazole inhibits the reaction [Ethanol results in decreased activity of CAT protein]
Omeprazole inhibits the reaction [Acetic Acid results in increased activity of CAT protein]
CTD PMID:18547560 PMID:28849987 PMID:33245926 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cbr1 carbonyl reductase 1 affects expression EXP Omeprazole affects the expression of CBR1 mRNA CTD PMID:19483382 NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393
JBrowse link
G Cckbr cholecystokinin B receptor multiple interactions ISO [Omeprazole co-treated with CCKBR protein] results in increased expression of IER3 CTD PMID:17704804 NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:159,771,733...159,814,881
JBrowse link
G Ccnd1 cyclin D1 decreases expression EXP Omeprazole results in decreased expression of CCND1 mRNA CTD PMID:17202759 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Omeprazole results in increased expression of CDKN1A protein CTD PMID:27358234 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdo1 cysteine dioxygenase type 1 affects expression EXP Omeprazole affects the expression of CDO1 mRNA CTD PMID:19483382 NCBI chr18:39,432,473...39,447,253
Ensembl chr18:39,432,474...39,447,296
JBrowse link
G Cept1 choline/ethanolamine phosphotransferase 1 affects expression EXP Omeprazole affects the expression of CEPT1 mRNA CTD PMID:19483382 NCBI chr 2:193,994,220...194,036,141
Ensembl chr 2:193,993,447...194,035,578
JBrowse link
G Ces2h carboxylesterase 2H affects expression EXP Omeprazole affects the expression of CES2 mRNA CTD PMID:19483382 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
JBrowse link
G Cfi complement factor I affects expression
decreases expression
EXP Omeprazole affects the expression of CFI mRNA
Omeprazole results in decreased expression of CFI mRNA
CTD PMID:19483382 PMID:25626140 NCBI chr 2:218,389,079...218,430,565
Ensembl chr 2:218,387,990...218,430,561
JBrowse link
G Cftr CF transmembrane conductance regulator affects metabolic processing ISO CFTR protein affects the metabolism of Omeprazole CTD PMID:15319328 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
JBrowse link
G Chp1 calcineurin-like EF-hand protein 1 affects expression EXP Omeprazole affects the expression of CHP1 mRNA CTD PMID:19483382 NCBI chr 3:106,536,009...106,571,255
Ensembl chr 3:106,536,004...106,571,251
JBrowse link
G Cisd1 CDGSH iron sulfur domain 1 affects expression EXP Omeprazole affects the expression of CISD1 mRNA CTD PMID:19483382 NCBI chr20:17,255,302...17,268,688
Ensembl chr20:17,255,151...17,284,924
JBrowse link
G Clcn4 chloride voltage-gated channel 4 affects expression EXP Omeprazole affects the expression of CLCN4 mRNA CTD PMID:19483382 NCBI chr  X:23,729,194...23,795,391
Ensembl chr  X:23,729,338...23,793,238
JBrowse link
G Clpp caseinolytic mitochondrial matrix peptidase proteolytic subunit affects expression EXP Omeprazole affects the expression of CLPP mRNA CTD PMID:19483382 NCBI chr 9:1,831,680...1,837,700
Ensembl chr 9:1,830,311...1,837,693
JBrowse link
G Clptm1l CLPTM1-like affects expression EXP Omeprazole affects the expression of CLPTM1L mRNA CTD PMID:19483382 NCBI chr 1:29,667,545...29,683,530
Ensembl chr 1:29,667,545...29,683,530
JBrowse link
G Cmbl carboxymethylenebutenolidase homolog affects expression EXP Omeprazole affects the expression of CMBL mRNA CTD PMID:19483382 NCBI chr 2:82,569,257...82,591,007
Ensembl chr 2:82,571,888...82,591,009
JBrowse link
G Cmpk1 cytidine/uridine monophosphate kinase 1 affects expression EXP Omeprazole affects the expression of CMPK1 mRNA CTD PMID:19483382 NCBI chr 5:128,480,301...128,507,830
Ensembl chr 5:128,480,301...128,507,830
JBrowse link
G Copg1 COPI coat complex subunit gamma 1 affects expression EXP Omeprazole affects the expression of COPG1 mRNA CTD PMID:19483382 NCBI chr 4:120,366,540...120,392,502
Ensembl chr 4:120,366,542...120,415,616
JBrowse link
G Cops4 COP9 signalosome subunit 4 affects expression EXP Omeprazole affects the expression of COPS4 mRNA CTD PMID:19483382 NCBI chr14:9,078,579...9,108,788
Ensembl chr14:9,078,576...9,108,887
JBrowse link
G Coq3 coenzyme Q3 methyltransferase affects expression EXP Omeprazole affects the expression of COQ3 mRNA CTD PMID:19483382 NCBI chr 5:35,429,567...35,460,613
Ensembl chr 5:35,429,574...35,460,607
JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4i1 affects expression EXP Omeprazole affects the expression of COX4I1 mRNA CTD PMID:19483382 NCBI chr19:48,721,680...48,727,920
Ensembl chr19:48,721,199...48,727,921
JBrowse link
G Cpn1 carboxypeptidase N subunit 1 affects expression EXP Omeprazole affects the expression of CPN1 mRNA CTD PMID:19483382 NCBI chr 1:242,844,575...242,873,465
Ensembl chr 1:242,844,212...242,873,465
JBrowse link
G Cpq carboxypeptidase Q affects expression EXP Omeprazole affects the expression of CPQ mRNA CTD PMID:19483382 NCBI chr 7:64,264,025...64,830,867
Ensembl chr 7:64,264,081...64,724,546
JBrowse link
G Crem cAMP responsive element modulator affects expression EXP Omeprazole affects the expression of CREM mRNA CTD PMID:19483382 NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989
JBrowse link
G Csnk2b casein kinase 2 beta affects expression EXP Omeprazole affects the expression of CSNK2B mRNA CTD PMID:19483382 NCBI chr20:3,700,363...3,705,331
Ensembl chr20:3,698,733...3,707,133
JBrowse link
G Csrp1 cysteine and glycine-rich protein 1 affects expression EXP Omeprazole affects the expression of CSRP1 mRNA CTD PMID:19483382 NCBI chr13:47,158,171...47,179,388
Ensembl chr13:47,167,789...47,179,384
JBrowse link
G Ctnna1 catenin alpha 1 affects expression EXP Omeprazole affects the expression of CTNNA1 mRNA CTD PMID:19483382 NCBI chr18:26,728,246...26,860,911
Ensembl chr18:26,728,485...26,860,910
JBrowse link
G Ctsb cathepsin B decreases activity ISO Omeprazole results in decreased activity of CTSB protein CTD PMID:34871754 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
JBrowse link
G Ctsd cathepsin D multiple interactions EXP Omeprazole inhibits the reaction [Cysteamine results in increased expression of CTSD protein] CTD PMID:20165931 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
JBrowse link
G Ctse cathepsin E decreases expression EXP Omeprazole results in decreased expression of CTSE CTD PMID:7575556 NCBI chr13:43,091,954...43,114,509
Ensembl chr13:43,092,128...43,114,502
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression
multiple interactions
ISO Omeprazole results in decreased expression of CXCR4 mRNA
AHR protein affects the reaction [Omeprazole results in decreased expression of CXCR4 mRNA]
CTD PMID:25826687 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity
multiple interactions
decreases activity
increases expression
ISO
EXP
Omeprazole results in increased activity of CYP1A1 promoter
Omeprazole inhibits the reaction [Oxygen results in increased expression of CYP1A1 protein]; Omeprazole promotes the reaction [Oxygen results in decreased expression of CYP1A1 mRNA]
Omeprazole results in decreased activity of CYP1A1 protein
Omeprazole results in increased expression of CYP1A1 mRNA; Omeprazole results in increased expression of CYP1A1 protein
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of CYP1A1 mRNA; AHR protein promotes the reaction [Omeprazole results in increased expression of CYP1A1 protein]; daidzein inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; daidzein inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; Genistein inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; Genistein inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; herbimycin inhibits the reaction [Omeprazole results in increased activity of CYP1A1 protein]; herbimycin inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; herbimycin inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; lavendustin A inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; Staurosporine inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; Tosyllysine Chloromethyl Ketone inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]
AHR protein affects the susceptibility to [Omeprazole results in increased expression of CYP1A1 mRNA]; AHR protein mutant form inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; AHR protein promotes the reaction [Omeprazole results in decreased expression of CYP1A1 mRNA]; herbimycin inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; Omeprazole promotes the reaction [AHR protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [ARNT protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [EP300 protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [NCOA1 protein binds to CYP1A1 promoter]
CTD PMID:8647108 PMID:8900397 PMID:9041675 PMID:9139728 PMID:9152597 More... NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases activity
increases expression
decreases activity
multiple interactions
ISO
EXP
Omeprazole results in increased activity of CYP1A2 promoter; Omeprazole results in increased activity of CYP1A2 protein
Omeprazole results in increased expression of CYP1A2 mRNA; Omeprazole results in increased expression of CYP1A2 protein
Omeprazole results in decreased activity of CYP1A2 protein
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of CYP1A2 mRNA
[Omeprazole results in increased expression of CYP1A2 protein] which results in decreased alkylation of Phenacetin; AHR protein affects the susceptibility to [Omeprazole results in increased expression of CYP1A2 mRNA]; Omeprazole results in increased expression of and results in increased activity of CYP1A2 protein
CTD PMID:9152597 PMID:9744552 PMID:12040753 PMID:12623754 PMID:12841937 More... NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
affects expression
decreases activity
increases expression
ISO Omeprazole promotes the reaction [AHR protein binds to CYP1B1 promoter]; Omeprazole promotes the reaction [ARNT protein binds to CYP1B1 promoter]; Omeprazole promotes the reaction [EP300 protein binds to CYP1B1 promoter]; Omeprazole promotes the reaction [NCOA1 protein binds to CYP1B1 promoter]
Omeprazole affects the expression of CYP1B1 mRNA
Omeprazole results in decreased activity of CYP1B1 protein
Omeprazole results in increased expression of CYP1B1 mRNA
CTD PMID:12040753 PMID:12623754 PMID:18420780 PMID:21703235 PMID:25826687 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 affects expression EXP Omeprazole affects the expression of CYP2A1 mRNA CTD PMID:19483382 NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP Omeprazole results in increased expression of CYP2B1 mRNA; Omeprazole results in increased expression of CYP2B1 protein CTD PMID:9152597 PMID:19118567 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression
affects expression
EXP Omeprazole results in increased expression of CYP2B2 protein
Omeprazole affects the expression of CYP2B2 mRNA
CTD PMID:9152597 PMID:19483382 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 affects expression
decreases activity
increases expression
increases activity
EXP
ISO
Omeprazole affects the expression of CYP2B3 mRNA
Omeprazole results in decreased activity of CYP2B10 protein
Omeprazole results in increased expression of CYP2B6 mRNA
Omeprazole results in increased activity of CYP2B6 protein
CTD PMID:17954527 PMID:18420780 PMID:19118567 PMID:19483382 PMID:22524704 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions ISO Omeprazole inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Diclofenac] CTD PMID:15258107 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases metabolic processing
decreases activity
multiple interactions
increases hydroxylation
increases metabolic processing
affects metabolic processing
ISO CYP2C19 gene alternative form results in decreased metabolism of Omeprazole
Omeprazole results in decreased activity of CYP2C19 protein
[5-bromotryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-chlorotryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-fluoro-alpha-methyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-fluorotryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-methyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [7-methyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [Chloramphenicol results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [Fluconazole results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [indopan results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [N,N-diallyl-5-methoxytryptamine results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [N,N-diisopropyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [Omeprazole results in decreased activity of CYP2C19 protein] which results in decreased chemical synthesis of 16-O-demethylaconitine metabolite; [Omeprazole results in decreased activity of CYP2C19 protein] which results in decreased chemical synthesis of Aconitine metabolite; [Tryptamines analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; Omeprazole affects the reaction [CYP2C19 protein affects the metabolism of Warfarin]; Omeprazole inhibits the reaction [CYP2C19 protein results in decreased methylation of adinazolam]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased chemical synthesis of 4-hydroxymephenytoin]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased hydroxylation of Mephenytoin]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased metabolism of auriculasin]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased metabolism of Fluoxetine]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased oxidation of 2-oxo-clopidogrel]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased oxidation of Clopidogrel]
CYP2C19 protein results in increased hydroxylation of Omeprazole
CYP2C19 protein results in increased metabolism of Omeprazole
CYP2C19 protein affects the metabolism of Omeprazole
CTD PMID:8930576 PMID:9600717 PMID:11752104 PMID:12464242 PMID:12467917 More... NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2d3 cytochrome P450, family 2, subfamily d, polypeptide 3 affects expression EXP Omeprazole affects the expression of CYP2D3 mRNA CTD PMID:19483382 NCBI chr 7:113,917,711...113,922,068
Ensembl chr 7:113,908,947...113,922,084
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects expression
decreases activity
EXP
ISO
Omeprazole affects the expression of CYP2D4 mRNA
Omeprazole results in decreased activity of CYP2D6 protein
CTD PMID:18420780 PMID:19483382 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO Omeprazole results in increased expression of and results in increased activity of CYP2E1 protein CTD PMID:15802389 PMID:36243147 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 affects expression EXP Omeprazole affects the expression of CYP2F4 mRNA CTD PMID:19483382 NCBI chr 1:82,416,107...82,429,897
Ensembl chr 1:82,416,130...82,429,896
JBrowse link
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 affects expression EXP Omeprazole affects the expression of CYP2J4 mRNA CTD PMID:19483382 NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
JBrowse link
G Cyp2t1 cytochrome P450, family 2, subfamily t, polypeptide 1 affects expression EXP Omeprazole affects the expression of CYP2T1 mRNA CTD PMID:19483382 NCBI chr 1:82,446,321...82,451,564
Ensembl chr 1:82,446,921...82,451,563
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects metabolic processing
increases metabolic processing
multiple interactions
increases expression
ISO CYP3A4 protein affects the metabolism of Omeprazole
CYP3A4 protein results in increased metabolism of Omeprazole
[Omeprazole results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; NR1I2 protein affects the reaction [Omeprazole results in increased expression of CYP3A4 mRNA]; Omeprazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]; Omeprazole results in increased expression of and results in increased activity of CYP3A4 protein
Omeprazole results in increased expression of CYP3A4 mRNA; Omeprazole results in increased expression of CYP3A4 protein
CTD PMID:7870052 PMID:8930576 PMID:9744552 PMID:12235278 PMID:12485723 More... NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 affects expression
increases expression
EXP Omeprazole affects the expression of CYP3A23-3A1 mRNA
Omeprazole results in increased expression of CYP3A23-3A1 mRNA
CTD PMID:19118567 PMID:19483382 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects expression
increases expression
EXP
ISO
Omeprazole affects the expression of CYP3A9 mRNA
Omeprazole results in increased expression of CYP3A5 mRNA
CTD PMID:19118567 PMID:19483382 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Cyp4a8 cytochrome P450, family 4, subfamily a, polypeptide 8 affects expression EXP Omeprazole affects the expression of CYP4A8 mRNA CTD PMID:19483382 NCBI chr 5:128,702,130...128,733,476
Ensembl chr 5:128,702,131...128,733,476
JBrowse link
G Cyp4f6 cytochrome P450, family 4, subfamily f, polypeptide 6 affects expression EXP Omeprazole affects the expression of CYP4F6 mRNA CTD PMID:19483382 NCBI chr 7:12,030,276...12,058,020
Ensembl chr 7:12,030,301...12,057,782
JBrowse link
G Dbi diazepam binding inhibitor affects expression EXP Omeprazole affects the expression of DBI mRNA CTD PMID:19483382 NCBI chr13:31,241,466...31,249,853
Ensembl chr13:31,206,988...31,268,693
JBrowse link
G Dcaf11 DDB1 and CUL4 associated factor 11 affects expression EXP Omeprazole affects the expression of DCAF11 mRNA CTD PMID:19483382 NCBI chr15:29,046,744...29,057,450
Ensembl chr15:29,046,826...29,057,669
JBrowse link
G Dcxr dicarbonyl and L-xylulose reductase affects expression EXP Omeprazole affects the expression of DCXR mRNA CTD PMID:19483382 NCBI chr10:106,006,404...106,008,293 JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Omeprazole results in increased expression of DDIT3 protein CTD PMID:27358234 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Decr1 2,4-dienoyl-CoA reductase 1 affects expression EXP Omeprazole affects the expression of DECR1 mRNA CTD PMID:19483382 NCBI chr 5:29,411,172...29,439,054
Ensembl chr 5:29,411,172...29,439,018
JBrowse link
G Dexi Dexi homolog affects expression EXP Omeprazole affects the expression of DEXI mRNA CTD PMID:19483382 NCBI chr10:5,126,021...5,138,746
Ensembl chr10:5,137,288...5,138,738
JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 affects expression EXP Omeprazole affects the expression of DGAT1 mRNA CTD PMID:19483382 NCBI chr 7:108,223,860...108,235,413
Ensembl chr 7:108,218,524...108,234,299
JBrowse link
G Dhcr24 24-dehydrocholesterol reductase affects expression EXP Omeprazole affects the expression of DHCR24 mRNA CTD PMID:19483382 NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137
JBrowse link
G Dhrs4 dehydrogenase/reductase 4 affects expression EXP Omeprazole affects the expression of DHRS4 mRNA CTD PMID:19483382 NCBI chr15:28,966,544...28,978,135
Ensembl chr15:28,966,553...28,978,127
JBrowse link
G Dhrs7b dehydrogenase/reductase 7B affects expression EXP Omeprazole affects the expression of DHRS7B mRNA CTD PMID:19483382 NCBI chr10:45,504,344...45,537,094
Ensembl chr10:45,504,426...45,537,076
JBrowse link
G Dhx16 DEAH-box helicase 16 affects expression EXP Omeprazole affects the expression of DHX16 mRNA CTD PMID:19483382 NCBI chr20:2,862,000...2,874,991
Ensembl chr20:2,862,000...2,874,948
JBrowse link
G Dmac2l distal membrane arm assembly component 2 like affects expression EXP Omeprazole affects the expression of DMAC2L mRNA CTD PMID:19483382 NCBI chr 6:88,205,580...88,223,934
Ensembl chr 6:88,205,700...88,223,933
JBrowse link
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 affects expression EXP Omeprazole affects the expression of DNAJC3 mRNA CTD PMID:19483382 NCBI chr15:96,025,605...96,068,585
Ensembl chr15:96,025,624...96,065,181
JBrowse link
G Dpp4 dipeptidylpeptidase 4 affects expression EXP Omeprazole affects the expression of DPP4 mRNA CTD PMID:19483382 NCBI chr 3:46,962,233...47,043,870
Ensembl chr 3:46,962,243...47,043,901
JBrowse link
G Dpyd dihydropyrimidine dehydrogenase affects expression EXP Omeprazole affects the expression of DPYD mRNA CTD PMID:19483382 NCBI chr 2:206,609,043...207,474,982
Ensembl chr 2:206,609,122...207,474,982
JBrowse link
G Ears2 glutamyl-tRNA synthetase 2, mitochondrial affects expression EXP Omeprazole affects the expression of EARS2 mRNA CTD PMID:19483382 NCBI chr 1:176,597,986...176,625,848
Ensembl chr 1:176,597,986...176,625,836
JBrowse link
G Echs1 enoyl-CoA hydratase, short chain 1 affects expression EXP Omeprazole affects the expression of ECHS1 mRNA CTD PMID:19483382 NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884
JBrowse link
G Eci1 enoyl-CoA delta isomerase 1 affects expression EXP Omeprazole affects the expression of ECI1 mRNA CTD PMID:19483382 NCBI chr10:13,456,715...13,470,061
Ensembl chr10:13,456,563...13,470,061
JBrowse link
G Eci2 enoyl-CoA delta isomerase 2 affects expression EXP Omeprazole affects the expression of ECI2 mRNA CTD PMID:19483382 NCBI chr17:29,850,884...29,886,781
Ensembl chr17:29,870,391...29,886,781
JBrowse link
G Eef1g eukaryotic translation elongation factor 1 gamma affects expression EXP Omeprazole affects the expression of EEF1G mRNA CTD PMID:19483382 NCBI chr 1:205,860,713...205,871,319
Ensembl chr 1:205,860,698...205,872,382
JBrowse link
G Egf epidermal growth factor multiple interactions ISO Omeprazole promotes the reaction [Indomethacin results in increased expression of EGF protein] CTD PMID:18431645 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Ehhadh enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase affects expression EXP Omeprazole affects the expression of EHHADH mRNA CTD PMID:19483382 NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188
JBrowse link
G Eif4a2 eukaryotic translation initiation factor 4A2 affects expression EXP Omeprazole affects the expression of EIF4A2 mRNA CTD PMID:19483382 NCBI chr11:77,764,126...77,770,810
Ensembl chr11:77,764,124...77,770,781
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 affects expression EXP Omeprazole affects the expression of EIF4EBP1 mRNA CTD PMID:19483382 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Eif4h eukaryotic translation initiation factor 4H affects expression EXP Omeprazole affects the expression of EIF4H mRNA CTD PMID:19483382 NCBI chr12:22,083,155...22,099,876
Ensembl chr12:22,082,835...22,099,876
JBrowse link
G Enc1 ectodermal-neural cortex 1 affects expression EXP Omeprazole affects the expression of ENC1 mRNA CTD PMID:19483382 NCBI chr 2:28,550,670...28,562,591
Ensembl chr 2:28,550,464...28,562,713
JBrowse link
G Eno1 enolase 1 affects expression EXP Omeprazole affects the expression of ENO1 mRNA CTD PMID:19483382 NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
JBrowse link
G Enpep glutamyl aminopeptidase affects expression EXP Omeprazole affects the expression of ENPEP mRNA CTD PMID:19483382 NCBI chr 2:217,781,985...217,851,947
Ensembl chr 2:217,782,005...217,851,947
JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 affects expression EXP Omeprazole affects the expression of ENPP1 mRNA CTD PMID:19483382 NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715
JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO Omeprazole promotes the reaction [EP300 protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [EP300 protein binds to CYP1B1 promoter] CTD PMID:21703235 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088
JBrowse link
G Epcam epithelial cell adhesion molecule affects expression EXP Omeprazole affects the expression of EPCAM mRNA CTD PMID:19483382 NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127
JBrowse link
G Erp29 endoplasmic reticulum protein 29 affects expression EXP Omeprazole affects the expression of ERP29 mRNA CTD PMID:19483382 NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376
JBrowse link
G Esd esterase D affects expression EXP Omeprazole affects the expression of ESD mRNA CTD PMID:19483382 NCBI chr15:50,043,634...50,063,134
Ensembl chr15:50,043,632...50,063,144
JBrowse link
G Etfb electron transfer flavoprotein subunit beta affects expression EXP Omeprazole affects the expression of ETFB mRNA CTD PMID:19483382 NCBI chr 1:93,851,908...93,866,072
Ensembl chr 1:93,851,858...93,866,068
JBrowse link
G Faah fatty acid amide hydrolase affects expression EXP Omeprazole affects the expression of FAAH mRNA CTD PMID:19483382 NCBI chr 5:129,479,774...129,499,018
Ensembl chr 5:129,479,824...129,498,677
JBrowse link
G Fads2 fatty acid desaturase 2 affects expression EXP Omeprazole affects the expression of FADS2 mRNA CTD PMID:19483382 NCBI chr 1:206,707,384...206,747,333
Ensembl chr 1:206,708,783...206,748,789
JBrowse link
G Fbp1 fructose-bisphosphatase 1 affects expression EXP Omeprazole affects the expression of FBP1 mRNA CTD PMID:19483382 NCBI chr17:2,207,271...2,230,076
Ensembl chr17:2,208,031...2,230,071
JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 affects expression EXP Omeprazole affects the expression of FDFT1 mRNA CTD PMID:19483382 NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287
JBrowse link
G Fdps farnesyl diphosphate synthase affects expression EXP Omeprazole affects the expression of FDPS mRNA CTD PMID:19483382 NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776
JBrowse link
G Fdx2 ferredoxin 2 affects expression EXP Omeprazole affects the expression of FDX2 mRNA CTD PMID:19483382 NCBI chr 8:19,604,916...19,609,832
Ensembl chr 8:19,604,916...19,609,849
JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 affects expression EXP Omeprazole affects the expression of FMO1 mRNA CTD PMID:19483382 NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647
JBrowse link
G Gamt guanidinoacetate N-methyltransferase affects expression EXP Omeprazole affects the expression of GAMT mRNA CTD PMID:19483382 NCBI chr 7:9,448,590...9,451,413
Ensembl chr 7:9,448,628...9,451,778
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase affects expression EXP Omeprazole affects the expression of GAPDH mRNA CTD PMID:19483382 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
JBrowse link
G Gast gastrin increases expression ISO
EXP
Omeprazole results in increased expression of GAST protein CTD PMID:11422300 PMID:12189558 PMID:12763636 PMID:15223672 PMID:16618411 More... NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496
JBrowse link
G Gbe1 1,4-alpha-glucan branching enzyme 1 affects expression EXP Omeprazole affects the expression of GBE1 mRNA CTD PMID:19483382 NCBI chr11:8,734,806...9,000,226
Ensembl chr11:8,734,820...9,000,210
JBrowse link
G Gchfr GTP cyclohydrolase I feedback regulator affects expression EXP Omeprazole affects the expression of GCHFR mRNA CTD PMID:19483382 NCBI chr 3:106,158,046...106,162,080
Ensembl chr 3:106,159,394...106,162,080
JBrowse link
G Ggh gamma-glutamyl hydrolase affects expression EXP Omeprazole affects the expression of GGH mRNA CTD PMID:19483382 NCBI chr 5:33,529,880...33,552,790
Ensembl chr 5:33,529,880...33,552,787
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions EXP [Omeprazole co-treated with Diethylnitrosamine] results in increased expression of GGT1 mRNA CTD PMID:22687989 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
JBrowse link
G Gjb1 gap junction protein, beta 1 affects expression EXP Omeprazole affects the expression of GJB1 mRNA CTD PMID:19483382 NCBI chr  X:66,501,848...66,509,783
Ensembl chr  X:66,501,820...66,509,925
JBrowse link
G Gpld1 glycosylphosphatidylinositol specific phospholipase D1 affects expression EXP Omeprazole affects the expression of GPLD1 mRNA CTD PMID:19483382 NCBI chr17:40,084,427...40,132,035
Ensembl chr17:40,084,617...40,126,939
JBrowse link
G Gpx1 glutathione peroxidase 1 affects expression EXP Omeprazole affects the expression of GPX1 mRNA CTD PMID:19483382 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gpx2 glutathione peroxidase 2 multiple interactions EXP [Omeprazole co-treated with Diethylnitrosamine] results in increased expression of GPX2 mRNA CTD PMID:22687989 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
JBrowse link
G Gpx4 glutathione peroxidase 4 affects expression EXP Omeprazole affects the expression of GPX4 mRNA CTD PMID:19483382 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
JBrowse link
G Grina glutamate ionotropic receptor NMDA type subunit associated protein 1 affects expression EXP Omeprazole affects the expression of GRINA mRNA CTD PMID:19483382 NCBI chr 7:107,962,194...107,965,372
Ensembl chr 7:107,962,207...107,965,366
JBrowse link
G Grpel1 GrpE-like 1, mitochondrial affects expression EXP Omeprazole affects the expression of GRPEL1 mRNA CTD PMID:19483382 NCBI chr14:74,292,023...74,298,243
Ensembl chr14:74,292,023...74,298,200
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases expression
multiple interactions
EXP Omeprazole results in increased expression of GSTA5 mRNA
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA
CTD PMID:17202759 PMID:22687989 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression EXP Omeprazole results in increased expression of GSTP1 mRNA CTD PMID:19118567 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Gstt1 glutathione S-transferase theta 1 affects expression EXP Omeprazole affects the expression of GSTT1 mRNA CTD PMID:19483382 NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
JBrowse link
G Gtf2h5 general transcription factor IIH subunit 5 affects expression EXP Omeprazole affects the expression of GTF2H5 mRNA CTD PMID:19483382 NCBI chr 1:46,656,804...46,663,512
Ensembl chr 1:46,656,859...46,664,939
JBrowse link
G Gzma granzyme A affects expression EXP Omeprazole affects the expression of GZMA mRNA CTD PMID:19483382 NCBI chr 2:44,740,569...44,752,502
Ensembl chr 2:44,740,569...44,752,493
JBrowse link
G H3f3b H3.3 histone B affects expression EXP Omeprazole affects the expression of H3F3B mRNA CTD PMID:19483382 NCBI chr10:101,256,484...101,258,716
Ensembl chr10:101,256,480...101,258,709
JBrowse link
G Hal histidine ammonia lyase affects expression EXP Omeprazole affects the expression of HAL mRNA CTD PMID:19483382 NCBI chr 7:28,007,449...28,037,701
Ensembl chr 7:28,006,972...28,037,701
JBrowse link
G Hamp hepcidin antimicrobial peptide increases expression
multiple interactions
increases secretion
ISO Omeprazole results in increased expression of HAMP mRNA
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Omeprazole results in increased expression of HAMP mRNA]; AHR protein affects the reaction [Omeprazole results in increased expression of HAMP mRNA]
Omeprazole results in increased expression of HAMP mRNA; Omeprazole results in increased expression of HAMP protein
Omeprazole results in increased secretion of HAMP protein
CTD PMID:31669099 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
JBrowse link
G Hao2 hydroxyacid oxidase 2 affects expression EXP Omeprazole affects the expression of HAO2 mRNA CTD PMID:19483382 NCBI chr 2:186,200,137...186,232,997
Ensembl chr 2:186,200,504...186,224,425
JBrowse link
G Hba-a2 hemoglobin alpha, adult chain 2 affects expression EXP Omeprazole affects the expression of HBA-A2 mRNA CTD PMID:19483382 NCBI chr10:15,323,830...15,324,677
Ensembl chr10:15,307,815...15,338,392
JBrowse link
G Hbb hemoglobin subunit beta affects expression EXP Omeprazole affects the expression of HBB mRNA CTD PMID:19483382 NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012
JBrowse link
G Hdc histidine decarboxylase affects expression
increases stability
increases expression
multiple interactions
EXP Omeprazole affects the expression of HDC mRNA
Omeprazole results in increased stability of HDC protein
Omeprazole results in increased expression of HDC mRNA
Omeprazole results in increased expression of and results in increased activity of HDC protein
CTD PMID:12763636 PMID:19483382 NCBI chr 3:113,847,256...113,865,334
Ensembl chr 3:113,847,260...113,865,341
JBrowse link
G Hgd homogentisate 1, 2-dioxygenase affects expression EXP Omeprazole affects the expression of HGD mRNA CTD PMID:19483382 NCBI chr11:63,086,750...63,138,325
Ensembl chr11:63,086,752...63,138,323
JBrowse link
G Hmgn1 high mobility group nucleosome binding domain 1 affects expression EXP Omeprazole affects the expression of HMGN1 mRNA CTD PMID:19483382 NCBI chr11:35,422,328...35,428,247
Ensembl chr11:35,422,328...35,428,254
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO Acetylcysteine promotes the reaction [Omeprazole results in increased expression of HMOX1 mRNA]; Acetylcysteine promotes the reaction [Omeprazole results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Omeprazole results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [Omeprazole results in increased expression of HMOX1 protein]; Omeprazole results in increased expression of and results in increased activity of HMOX1 protein
Omeprazole results in increased expression of HMOX1 mRNA; Omeprazole results in increased expression of HMOX1 protein
CTD PMID:16712795 PMID:27725188 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 affects expression EXP Omeprazole affects the expression of HPRT1 mRNA CTD PMID:19483382 NCBI chr  X:132,736,175...132,768,149
Ensembl chr  X:132,736,096...132,768,154
JBrowse link
G Hps5 HPS5, biogenesis of lysosomal organelles complex 2 subunit 2 affects expression EXP Omeprazole affects the expression of HPS5 mRNA CTD PMID:19483382 NCBI chr 1:97,281,626...97,320,945
Ensembl chr 1:97,247,598...97,321,019
JBrowse link
G Hsd17b4 hydroxysteroid (17-beta) dehydrogenase 4 affects expression EXP Omeprazole affects the expression of HSD17B4 mRNA CTD PMID:19483382 NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952
JBrowse link
G Hsdl2 hydroxysteroid dehydrogenase like 2 affects expression EXP Omeprazole affects the expression of HSDL2 mRNA CTD PMID:19483382 NCBI chr 5:74,443,933...74,479,104
Ensembl chr 5:74,443,872...74,479,839
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A decreases expression
multiple interactions
EXP Omeprazole results in decreased expression of HSPA1A mRNA; Omeprazole results in decreased expression of HSPA1A protein
Zinc Compounds analog inhibits the reaction [Omeprazole results in decreased expression of HSPA1A protein]; Zinc Sulfate inhibits the reaction [Omeprazole results in decreased expression of HSPA1A protein]
CTD PMID:15223672 PMID:16945336 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like multiple interactions EXP Omeprazole inhibits the reaction [Ethanol results in increased expression of HSPA1L mRNA] CTD PMID:25637687 NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571
JBrowse link
G Htra1 HtrA serine peptidase 1 affects expression EXP Omeprazole affects the expression of HTRA1 mRNA CTD PMID:19483382 NCBI chr 1:185,497,815...185,547,380
Ensembl chr 1:185,497,735...185,547,379
JBrowse link
G Ier3 immediate early response 3 multiple interactions ISO [Omeprazole co-treated with CCKBR protein] results in increased expression of IER3 CTD PMID:17704804 NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583
JBrowse link
G Ifng interferon gamma multiple interactions ISO Omeprazole inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein] CTD PMID:19232345 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Igf1 insulin-like growth factor 1 affects expression EXP Omeprazole affects the expression of IGF1 mRNA CTD PMID:19483382 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igfals insulin-like growth factor binding protein, acid labile subunit affects expression EXP Omeprazole affects the expression of IGFALS mRNA CTD PMID:19483382 NCBI chr10:13,897,468...13,903,920
Ensembl chr10:13,898,395...13,902,677
JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 affects expression EXP Omeprazole affects the expression of IGFBP2 mRNA CTD PMID:19483382 NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Omeprazole inhibits the reaction [Ethanol results in decreased expression of IL10 protein] CTD PMID:26970604 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Omeprazole inhibits the reaction [Cisplatin results in increased expression of IL1B protein] CTD PMID:32418911 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions EXP Omeprazole inhibits the reaction [Cisplatin results in increased expression of IL6 protein]; Omeprazole inhibits the reaction [Ethanol results in decreased expression of IL6 protein] CTD PMID:25637687 PMID:32418911 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Impa1 inositol monophosphatase 1 affects expression EXP Omeprazole affects the expression of IMPA1 mRNA CTD PMID:19483382 NCBI chr 2:91,462,781...91,484,057
Ensembl chr 2:91,462,799...91,484,313
JBrowse link
G Inhbe inhibin subunit beta E affects expression EXP Omeprazole affects the expression of INHBE mRNA CTD PMID:19483382 NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172
JBrowse link
G Isyna1 inositol-3-phosphate synthase 1 affects expression EXP Omeprazole affects the expression of ISYNA1 mRNA CTD PMID:19483382 NCBI chr16:18,839,143...18,841,979
Ensembl chr16:18,839,145...18,841,979
JBrowse link
G Itih4 inter-alpha-trypsin inhibitor heavy chain 4 affects expression EXP Omeprazole affects the expression of ITIH4 mRNA CTD PMID:19483382 NCBI chr16:6,080,539...6,095,710
Ensembl chr16:6,080,539...6,095,708
JBrowse link
G Jak1 Janus kinase 1 affects expression EXP Omeprazole affects the expression of JAK1 mRNA CTD PMID:19483382 NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926
JBrowse link
G Kdelr2 KDEL endoplasmic reticulum protein retention receptor 2 affects expression EXP Omeprazole affects the expression of KDELR2 mRNA CTD PMID:19483382 NCBI chr12:11,138,820...11,157,117
Ensembl chr12:11,138,820...11,157,153
JBrowse link
G Kdr kinase insert domain receptor affects expression
multiple interactions
EXP
ISO
Omeprazole affects the expression of KDR mRNA
Omeprazole promotes the reaction [Oxygen results in decreased expression of KDR protein]
CTD PMID:19483382 PMID:26272953 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
JBrowse link
G Krt8 keratin 8 affects expression EXP Omeprazole affects the expression of KRT8 mRNA CTD PMID:19483382 NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728
JBrowse link
G Lcat lecithin cholesterol acyltransferase affects expression EXP Omeprazole affects the expression of LCAT mRNA CTD PMID:19483382 NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231
JBrowse link
G Lcmt1 leucine carboxyl methyltransferase 1 affects expression EXP Omeprazole affects the expression of LCMT1 mRNA CTD PMID:19483382 NCBI chr 1:177,904,119...177,960,111
Ensembl chr 1:177,904,139...177,960,112
JBrowse link
G Lipc lipase C, hepatic type affects expression EXP Omeprazole affects the expression of LIPC mRNA CTD PMID:19483382 NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464
JBrowse link
G Lox lysyl oxidase affects expression EXP Omeprazole affects the expression of LOX mRNA CTD PMID:19483382 NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477
JBrowse link
G Lrp3 LDL receptor related protein 3 affects expression EXP Omeprazole affects the expression of LRP3 mRNA CTD PMID:19483382 NCBI chr 1:87,843,815...87,859,147
Ensembl chr 1:87,844,868...87,859,110
JBrowse link
G Man2b1 mannosidase, alpha, class 2B, member 1 affects expression EXP Omeprazole affects the expression of MAN2B1 mRNA CTD PMID:19483382 NCBI chr19:23,055,092...23,074,398
Ensembl chr19:23,055,097...23,074,389
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 affects expression EXP Omeprazole affects the expression of MAP2K2 mRNA CTD PMID:19483382 NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO Omeprazole inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK14 protein] CTD PMID:17406807 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Masp2 MBL associated serine protease 2 affects expression EXP Omeprazole affects the expression of MASP2 mRNA CTD PMID:19483382 NCBI chr 5:159,035,892...159,049,561
Ensembl chr 5:159,035,911...159,049,580
JBrowse link
G Me1 malic enzyme 1 affects expression
multiple interactions
EXP Omeprazole affects the expression of ME1 mRNA
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of ME1 mRNA
CTD PMID:19483382 PMID:22687989 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
JBrowse link
G Mmp14 matrix metallopeptidase 14 multiple interactions EXP Omeprazole inhibits the reaction [Indomethacin results in decreased expression of MMP14 protein] CTD PMID:16934674 NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP Omeprazole inhibits the reaction [Hydrogen Peroxide results in decreased activity of MMP2 protein] CTD PMID:16934674 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmut methylmalonyl-CoA mutase affects expression EXP Omeprazole affects the expression of MMUT mRNA CTD PMID:19483382 NCBI chr 9:19,928,720...19,956,985
Ensembl chr 9:19,928,727...19,957,046
JBrowse link
G Mpo myeloperoxidase multiple interactions
decreases activity
ISO
EXP
Omeprazole inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of MPO protein]; Omeprazole inhibits the reaction [Acids results in increased activity of MPO protein]
Omeprazole results in decreased activity of MPO protein
Omeprazole inhibits the reaction [Acetic Acid results in increased activity of MPO protein]; Omeprazole inhibits the reaction [Cysteamine results in increased expression of MPO protein]; Omeprazole inhibits the reaction [Ethanol results in increased activity of MPO protein]; Omeprazole inhibits the reaction [Indomethacin results in increased activity of MPO protein]
CTD PMID:16091555 PMID:17151854 PMID:20165931 PMID:25637687 PMID:27780710 More... NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mro maestro affects expression EXP Omeprazole affects the expression of MRO mRNA CTD PMID:19483382 NCBI chr18:67,450,186...67,467,593
Ensembl chr18:67,450,595...67,467,044
JBrowse link
G Mrpl2 mitochondrial ribosomal protein L2 affects expression EXP Omeprazole affects the expression of MRPL2 mRNA CTD PMID:19483382 NCBI chr 9:14,333,233...14,337,006
Ensembl chr 9:14,333,234...14,337,040
JBrowse link
G mrpl9 mitochondrial ribosomal protein L9 affects expression EXP Omeprazole affects the expression of MRPL9 mRNA CTD PMID:19483382 NCBI chr 2:182,082,012...182,086,758
Ensembl chr 2:182,076,369...182,087,095
JBrowse link
G Mug2 murinoglobulin 2 affects expression EXP Omeprazole affects the expression of PZP mRNA CTD PMID:19483382 NCBI chr 4:155,164,061...155,236,894
Ensembl chr 4:155,164,011...155,236,475
JBrowse link
G Myadm myeloid-associated differentiation marker affects expression EXP Omeprazole affects the expression of MYADM mRNA CTD PMID:19483382 NCBI chr 1:65,864,180...65,874,701
Ensembl chr 1:65,864,173...65,874,035
JBrowse link
G Mycbp2 MYC binding protein 2 affects expression EXP Omeprazole affects the expression of MYCBP2 mRNA CTD PMID:19483382 NCBI chr15:79,937,354...80,175,432
Ensembl chr15:79,937,354...80,175,498
JBrowse link
G Myo1d myosin ID affects expression EXP Omeprazole affects the expression of MYO1D mRNA CTD PMID:19483382 NCBI chr10:65,489,153...65,765,812
Ensembl chr10:65,489,154...65,766,349
JBrowse link
G Naa38 N(alpha)-acetyltransferase 38, NatC auxiliary subunit affects expression EXP Omeprazole affects the expression of NAA38 mRNA CTD PMID:19483382 NCBI chr10:54,117,754...54,118,913
Ensembl chr10:54,117,163...54,119,494
JBrowse link
G Nap1l1 nucleosome assembly protein 1-like 1 affects expression EXP Omeprazole affects the expression of NAP1L1 mRNA CTD PMID:19483382 NCBI chr 7:46,933,278...46,957,853
Ensembl chr 7:46,933,356...46,956,593
JBrowse link
G Nat8 N-acetyltransferase 8 affects expression EXP Omeprazole affects the expression of NAT8 mRNA CTD PMID:19483382 NCBI chr 4:118,279,521...118,284,671
Ensembl chr 4:118,270,954...118,281,763
JBrowse link
G Ncoa1 nuclear receptor coactivator 1 multiple interactions ISO Omeprazole promotes the reaction [NCOA1 protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [NCOA1 protein binds to CYP1B1 promoter] CTD PMID:21703235 NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664
JBrowse link
G Ndrg2 NDRG family member 2 affects expression EXP Omeprazole affects the expression of NDRG2 mRNA CTD PMID:19483382 NCBI chr15:24,600,981...24,609,621
Ensembl chr15:24,600,982...24,609,626
JBrowse link
G Ndufs5 NADH:ubiquinone oxidoreductase subunit S5 affects expression EXP Omeprazole affects the expression of NDUFS5 mRNA CTD PMID:19483382 NCBI chr 5:135,974,029...135,979,705
Ensembl chr 5:135,974,034...135,979,603
Ensembl chr14:135,974,034...135,979,603
Ensembl chr 2:135,974,034...135,979,603
JBrowse link
G Ndufv3 NADH:ubiquinone oxidoreductase subunit V3 affects expression EXP Omeprazole affects the expression of NDUFV3 mRNA CTD PMID:19483382 NCBI chr20:9,612,462...9,621,622
Ensembl chr20:9,612,431...9,623,074
Ensembl chr13:9,612,431...9,623,074
JBrowse link
G Neu2 neuraminidase 2 affects expression EXP Omeprazole affects the expression of NEU2 mRNA CTD PMID:19483382 NCBI chr 9:88,218,494...88,267,356
Ensembl chr 9:88,249,135...88,267,355
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO NFE2L2 protein affects the reaction [Omeprazole results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [Omeprazole results in increased expression of HMOX1 protein] CTD PMID:27725188 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP Omeprazole inhibits the reaction [Cisplatin results in decreased expression of NFKBIA protein] CTD PMID:32418911 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nfx1 nuclear transcription factor, X-box binding 1 affects expression EXP Omeprazole affects the expression of NFX1 mRNA CTD PMID:19483382 NCBI chr 5:56,104,945...56,162,912
Ensembl chr 5:56,105,234...56,162,912
JBrowse link
G Nipal2 NIPA-like domain containing 2 affects expression EXP Omeprazole affects the expression of NIPAL2 mRNA CTD PMID:19483382 NCBI chr 7:65,774,477...65,884,807
Ensembl chr 7:65,774,477...65,884,807
JBrowse link
G Nit1 nitrilase 1 affects expression EXP Omeprazole affects the expression of NIT1 mRNA CTD PMID:19483382 NCBI chr13:83,769,888...83,773,324
Ensembl chr13:83,765,941...83,773,332
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP Lipopolysaccharides inhibits the reaction [Omeprazole inhibits the reaction [Cisplatin results in increased expression of NLRP3 protein]]; Omeprazole inhibits the reaction [Cisplatin results in increased expression of NLRP3 protein] CTD PMID:32418911 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Nme2 NME/NM23 nucleoside diphosphate kinase 2 affects expression EXP Omeprazole affects the expression of NME2 mRNA CTD PMID:19483382 NCBI chr10:78,898,097...78,903,514
Ensembl chr10:78,897,770...78,903,538
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
EXP
ISO
Omeprazole results in increased expression of NQO1 mRNA
Omeprazole inhibits the reaction [Oxygen results in increased expression of NQO1 mRNA]; Omeprazole inhibits the reaction [Oxygen results in increased expression of NQO1 protein]
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of NQO1 mRNA
CTD PMID:17202759 PMID:22687989 PMID:26272953 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
ISO
EXP
[Omeprazole results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; NR1I2 protein affects the reaction [Omeprazole results in increased expression of CYP3A4 mRNA] CTD PMID:12695340 PMID:17041008 PMID:25680588 PMID:26187274 PMID:27732639 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 affects expression
decreases metabolic processing
increases expression
EXP
ISO
Omeprazole affects the expression of NR1I3 mRNA
NR1I3 gene mutant form results in decreased metabolism of Omeprazole
Omeprazole results in increased expression of NR1I3 mRNA
CTD PMID:19118567 PMID:19483382 PMID:27434302 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 affects expression EXP Omeprazole affects the expression of NR3C1 mRNA CTD PMID:19483382 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Oaf out at first homolog affects expression EXP Omeprazole affects the expression of OAF mRNA CTD PMID:19483382 NCBI chr 8:43,594,362...43,612,334
Ensembl chr 8:43,594,363...43,612,334
JBrowse link
G Obp3 alpha-2u globulin PGCL4 affects expression EXP Omeprazole affects the expression of OBP3 mRNA CTD PMID:19483382 NCBI chr 5:74,842,316...74,845,858
Ensembl chr 5:74,842,316...74,845,757
JBrowse link
G Ogdh oxoglutarate dehydrogenase affects expression EXP Omeprazole affects the expression of OGDH mRNA CTD PMID:19483382 NCBI chr14:81,150,021...81,217,479
Ensembl chr14:81,150,091...81,217,479
JBrowse link
G Olr59 olfactory receptor 59 affects expression EXP Omeprazole affects the expression of OLR59 mRNA CTD PMID:19483382 NCBI chr 1:157,193,051...157,227,707
Ensembl chr 1:157,193,080...157,211,179
JBrowse link
G Ostc oligosaccharyltransferase complex non-catalytic subunit affects expression EXP Omeprazole affects the expression of OSTC mRNA CTD PMID:19483382 NCBI chr 2:219,250,549...219,266,076
Ensembl chr 2:219,236,952...219,266,107
JBrowse link
G Otc ornithine transcarbamylase affects expression EXP Omeprazole affects the expression of OTC mRNA CTD PMID:19483382 NCBI chr  X:12,453,834...12,529,954
Ensembl chr  X:12,453,834...12,566,918
JBrowse link
G Pabpc4 poly(A) binding protein, cytoplasmic 4 affects expression EXP Omeprazole affects the expression of PABPC4 mRNA CTD PMID:19483382 NCBI chr 5:135,563,142...135,578,985
Ensembl chr 5:135,563,562...135,578,979
JBrowse link
G Paics phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase affects expression EXP Omeprazole affects the expression of PAICS mRNA CTD PMID:19483382 NCBI chr14:31,199,086...31,232,731
Ensembl chr14:31,173,541...31,232,635
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Omeprazole results in increased cleavage of PARP1 protein CTD PMID:15461867 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pc pyruvate carboxylase affects expression EXP Omeprazole affects the expression of PCX mRNA CTD PMID:19483382 NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380
JBrowse link
G Pccb propionyl-CoA carboxylase subunit beta affects expression EXP Omeprazole affects the expression of PCCB mRNA CTD PMID:19483382 NCBI chr 8:101,591,218...101,641,213
Ensembl chr 8:101,590,737...101,641,234
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP
ISO
[Omeprazole co-treated with Indomethacin] promotes the reaction [Acetic Acid results in increased expression of PCNA protein]; Omeprazole promotes the reaction [Acetic Acid results in increased expression of PCNA protein]
Omeprazole inhibits the reaction [Ethanol results in decreased expression of PCNA protein]
CTD PMID:19251492 PMID:26970604 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pcsk6 proprotein convertase subtilisin/kexin type 6 affects expression EXP Omeprazole affects the expression of PCSK6 mRNA CTD PMID:19483382 NCBI chr 1:119,428,978...119,627,626
Ensembl chr 1:119,429,265...119,627,596
JBrowse link
G Pctp phosphatidylcholine transfer protein affects expression EXP Omeprazole affects the expression of PCTP mRNA CTD PMID:19483382 NCBI chr10:74,808,887...74,856,260
Ensembl chr10:74,808,887...74,849,867
JBrowse link
G Pdcl3 phosducin-like 3 affects expression EXP Omeprazole affects the expression of PDCL3 mRNA CTD PMID:19483382 NCBI chr 9:41,234,322...41,243,769
Ensembl chr 9:41,234,234...41,243,735
JBrowse link
G Pdia3 protein disulfide isomerase family A, member 3 affects expression EXP Omeprazole affects the expression of PDIA3 mRNA CTD PMID:19483382 NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236
JBrowse link
G Pdia6 protein disulfide isomerase family A, member 6 affects expression EXP Omeprazole affects the expression of PDIA6 mRNA CTD PMID:19483382 NCBI chr 6:40,062,980...40,080,223
Ensembl chr 6:40,062,926...40,080,613
JBrowse link
G Pex19 peroxisomal biogenesis factor 19 affects expression EXP Omeprazole affects the expression of PEX19 mRNA CTD PMID:19483382 NCBI chr13:84,592,277...84,608,793
Ensembl chr13:84,592,312...84,608,608
JBrowse link
G Pgam1 phosphoglycerate mutase 1 affects expression EXP Omeprazole affects the expression of PGAM1 mRNA CTD PMID:19483382 NCBI chr 1:240,723,832...240,731,443
Ensembl chr 1:240,723,920...240,738,452
JBrowse link
G Pgrmc1 progesterone receptor membrane component 1 affects expression EXP Omeprazole affects the expression of PGRMC1 mRNA CTD PMID:19483382 NCBI chr  X:115,832,865...115,841,060
Ensembl chr  X:115,832,884...115,888,682
JBrowse link
G Phyh phytanoyl-CoA 2-hydroxylase affects expression EXP Omeprazole affects the expression of PHYH mRNA CTD PMID:19483382 NCBI chr17:73,329,461...73,346,359
Ensembl chr17:73,329,082...73,346,409
JBrowse link
G Pigp phosphatidylinositol glycan anchor biosynthesis, class P affects expression EXP Omeprazole affects the expression of PIGP mRNA CTD PMID:19483382 NCBI chr11:33,682,943...33,689,111
Ensembl chr11:33,682,948...33,689,321
JBrowse link
G Pklr pyruvate kinase L/R affects expression EXP Omeprazole affects the expression of PKLR mRNA CTD PMID:19483382 NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870
JBrowse link
G Pla2g4a phospholipase A2 group IVA increases phosphorylation
multiple interactions
ISO Omeprazole results in increased phosphorylation of PLA2G4A protein
4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Omeprazole results in increased phosphorylation of PLA2G4A protein]
CTD PMID:25797602 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266
JBrowse link
G Plbd1 phospholipase B domain containing 1 affects expression EXP Omeprazole affects the expression of PLBD1 mRNA CTD PMID:19483382 NCBI chr 4:169,472,983...169,529,277
Ensembl chr 4:169,472,983...169,529,277
JBrowse link
G Plg plasminogen affects expression EXP Omeprazole affects the expression of PLG mRNA CTD PMID:19483382 NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786
JBrowse link
G Pls3 plastin 3 affects expression EXP Omeprazole affects the expression of PLS3 mRNA CTD PMID:19483382 NCBI chr  X:111,589,193...111,683,908
Ensembl chr  X:111,589,254...111,683,891
JBrowse link
G Pon2 paraoxonase 2 affects expression EXP Omeprazole affects the expression of PON2 mRNA CTD PMID:19483382 NCBI chr 4:33,389,702...33,425,186
Ensembl chr 4:33,389,714...33,425,248
JBrowse link
G Pou2f2 POU class 2 homeobox 2 multiple interactions EXP
ISO
Omeprazole inhibits the reaction [Cisplatin results in increased expression of POU2F2 protein] CTD PMID:30452898 NCBI chr 1:80,682,330...80,769,756
Ensembl chr 1:80,685,741...80,724,261
JBrowse link
G Ppdpf pancreatic progenitor cell differentiation and proliferation factor affects expression EXP Omeprazole affects the expression of PPDPF mRNA CTD PMID:19483382 NCBI chr 3:168,299,309...168,301,040
Ensembl chr 3:168,299,791...168,301,036
JBrowse link
G Prdx2 peroxiredoxin 2 affects expression EXP Omeprazole affects the expression of PRDX2 mRNA CTD PMID:19483382 NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194
JBrowse link
G Prdx6 peroxiredoxin 6 affects expression EXP Omeprazole affects the expression of PRDX6 mRNA CTD PMID:19483382 NCBI chr13:73,528,746...73,539,295
Ensembl chr13:73,528,210...73,539,355
JBrowse link
G Prl prolactin increases expression ISO Omeprazole results in increased expression of PRL protein CTD PMID:20726208 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Proc protein C, inactivator of coagulation factors Va and VIIIa affects expression EXP Omeprazole affects the expression of PROC mRNA CTD PMID:19483382 NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133
JBrowse link
G Prpsap1 phosphoribosyl pyrophosphate synthetase-associated protein 1 affects expression EXP Omeprazole affects the expression of PRPSAP1 mRNA CTD PMID:19483382 NCBI chr10:101,701,094...101,750,753
Ensembl chr10:101,701,096...101,750,751
JBrowse link
G Psma6 proteasome 20S subunit alpha 6 affects expression EXP Omeprazole affects the expression of PSMA6 mRNA CTD PMID:19483382 NCBI chr 6:72,765,534...72,796,554
Ensembl chr 6:72,765,473...72,796,554
JBrowse link
G Psmb1 proteasome 20S subunit beta 1 affects expression EXP Omeprazole affects the expression of PSMB1 mRNA CTD PMID:19483382 NCBI chr 1:56,442,432...56,463,544
Ensembl chr 1:56,420,618...56,463,560
JBrowse link
G Psmb3 proteasome 20S subunit beta 3 affects expression EXP Omeprazole affects the expression of PSMB3 mRNA CTD PMID:19483382 NCBI chr10:82,697,425...82,704,521
Ensembl chr10:82,697,425...82,704,521
JBrowse link
G Psmc1 proteasome 26S subunit, ATPase 1 affects expression EXP Omeprazole affects the expression of PSMC1 mRNA CTD PMID:19483382 NCBI chr 6:119,392,833...119,405,233
Ensembl chr 6:119,392,855...119,410,123
JBrowse link
G Psmc3 proteasome 26S subunit, ATPase 3 affects expression EXP Omeprazole affects the expression of PSMC3 mRNA CTD PMID:19483382 NCBI chr 3:77,031,825...77,037,207
Ensembl chr 3:77,031,825...77,043,358
JBrowse link
G Psmc5 proteasome 26S subunit, ATPase 5 affects expression EXP Omeprazole affects the expression of PSMC5 mRNA CTD PMID:19483382 NCBI chr10:91,187,763...91,193,697
Ensembl chr10:91,187,743...91,213,135
JBrowse link
G Psmd1 proteasome 26S subunit, non-ATPase 1 affects expression EXP Omeprazole affects the expression of PSMD1 mRNA CTD PMID:19483382 NCBI chr 9:86,709,714...86,785,213
Ensembl chr 9:86,709,947...86,785,211
JBrowse link
G Psmd4 proteasome 26S subunit ubiquitin receptor, non-ATPase 4 affects expression EXP Omeprazole affects the expression of PSMD4 mRNA CTD PMID:19483382 NCBI chr 2:182,598,934...182,608,250
Ensembl chr 2:182,598,934...182,608,194
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP
ISO
[Omeprazole co-treated with beta-Naphthoflavone] results in increased expression of PTGS2 mRNA; [Omeprazole co-treated with beta-Naphthoflavone] results in increased expression of PTGS2 protein
Omeprazole inhibits the reaction [Ethanol results in increased expression of PTGS2 protein]
CTD PMID:23038005 PMID:26970604 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ptms parathymosin affects expression EXP Omeprazole affects the expression of PTMS mRNA CTD PMID:19483382 NCBI chr 4:157,722,384...157,726,575
Ensembl chr 4:157,722,386...157,727,009
JBrowse link
G Ptprf protein tyrosine phosphatase, receptor type, F affects expression EXP Omeprazole affects the expression of PTPRF mRNA CTD PMID:19483382 NCBI chr 5:131,741,959...131,824,000
Ensembl chr 5:131,742,754...131,810,023
JBrowse link
G Pttg1ip PTTG1 interacting protein affects expression EXP Omeprazole affects the expression of PTTG1IP mRNA CTD PMID:19483382 NCBI chr20:11,030,013...11,047,742
Ensembl chr20:11,030,015...11,047,316
JBrowse link
G Pygl glycogen phosphorylase L affects expression EXP Omeprazole affects the expression of PYGL mRNA CTD PMID:19483382 NCBI chr 6:88,697,598...88,740,260
Ensembl chr 6:88,697,593...88,740,310
JBrowse link
G Rab5if RAB5 interacting factor affects expression EXP Omeprazole affects the expression of RAB5IF mRNA CTD PMID:19483382 NCBI chr 3:145,357,990...145,368,012
Ensembl chr 3:145,357,861...145,368,012
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO
[Omeprazole co-treated with Indomethacin] promotes the reaction [Acetic Acid results in increased expression of RELA protein]; Lipopolysaccharides inhibits the reaction [Omeprazole inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein]]; Omeprazole inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein]
Omeprazole inhibits the reaction [Cisplatin affects the localization of RELA protein]
CTD PMID:19251492 PMID:30452898 PMID:32418911 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Retsat retinol saturase increases expression EXP Omeprazole results in increased expression of RETSAT mRNA CTD PMID:25626140 NCBI chr 4:104,653,306...104,662,069
Ensembl chr 4:104,653,155...104,668,310
JBrowse link
G Rida reactive intermediate imine deaminase A homolog affects expression EXP Omeprazole affects the expression of RIDA mRNA CTD PMID:19483382 NCBI chr 7:65,691,429...65,705,257
Ensembl chr 7:65,691,435...65,705,716
JBrowse link
G Rnase4 ribonuclease A family member 4 affects expression EXP Omeprazole affects the expression of RNASE4 mRNA CTD PMID:19483382 NCBI chr15:24,312,765...24,330,112
Ensembl chr15:24,312,464...24,330,117
JBrowse link
G Rnf103 ring finger protein 103 affects expression EXP Omeprazole affects the expression of RNF103 mRNA CTD PMID:19483382 NCBI chr 4:103,526,456...103,542,529
Ensembl chr 4:103,526,502...103,555,919
JBrowse link
G Rnps1 RNA binding protein with serine rich domain 1 affects expression EXP Omeprazole affects the expression of RNPS1 mRNA CTD PMID:19483382 NCBI chr10:13,445,516...13,455,858
Ensembl chr10:13,445,653...13,455,858
JBrowse link
G Rpl11 ribosomal protein L11 affects expression EXP Omeprazole affects the expression of RPL11 mRNA CTD PMID:19483382 NCBI chr 5:148,274,060...148,277,708
Ensembl chr 5:148,274,069...148,277,599
JBrowse link
G Rpl13 ribosomal protein L13 affects expression EXP Omeprazole affects the expression of RPL13 mRNA CTD PMID:19483382 NCBI chr19:51,153,990...51,156,541
Ensembl chr19:51,153,924...51,163,014
JBrowse link
G Rpl15 ribosomal protein L15 affects expression EXP Omeprazole affects the expression of RPL15 mRNA CTD PMID:19483382 NCBI chr15:7,503,883...7,507,166
Ensembl chr15:7,503,883...7,507,165
JBrowse link
G Rpl17 ribosomal protein L17 affects expression EXP Omeprazole affects the expression of RPL17 mRNA CTD PMID:19483382 NCBI chr18:68,581,141...68,584,253
Ensembl chr18:68,581,098...68,584,253
JBrowse link
G Rpl23 ribosomal protein L23 affects expression EXP Omeprazole affects the expression of RPL23 mRNA CTD PMID:19483382 NCBI chr10:82,771,878...82,775,840
Ensembl chr10:82,771,538...82,775,870
JBrowse link
G Rpl3 ribosomal protein L3 affects expression EXP Omeprazole affects the expression of RPL3 mRNA CTD PMID:19483382 NCBI chr 7:111,622,255...111,627,640
Ensembl chr 7:111,621,610...111,636,468
JBrowse link
G Rpl32 ribosomal protein L32 affects expression EXP Omeprazole affects the expression of RPL32 mRNA CTD PMID:19483382 NCBI chr 4:148,864,048...148,867,612
Ensembl chr 4:148,864,044...148,867,612
JBrowse link
G Rpl4 ribosomal protein L4 affects expression EXP Omeprazole affects the expression of RPL4 mRNA CTD PMID:19483382 NCBI chr 8:64,671,177...64,676,301
Ensembl chr 8:64,671,160...64,676,306
JBrowse link
G Rpn2 ribophorin II affects expression EXP Omeprazole affects the expression of RPN2 mRNA CTD PMID:19483382 NCBI chr 3:145,941,787...145,989,271
Ensembl chr 3:145,941,839...145,989,543
JBrowse link
G Rps14 ribosomal protein S14 affects expression EXP Omeprazole affects the expression of RPS14 mRNA CTD PMID:19483382 NCBI chr18:54,227,854...54,232,638
Ensembl chr18:54,227,854...54,233,166
JBrowse link
G Rps18 ribosomal protein S18 affects expression EXP Omeprazole affects the expression of RPS18 mRNA CTD PMID:19483382 NCBI chr20:4,931,427...4,935,538
Ensembl chr10:101,204,500...101,205,146
Ensembl chr20:101,204,500...101,205,146
JBrowse link
G Rps19 ribosomal protein S19 affects expression EXP Omeprazole affects the expression of RPS19 mRNA CTD PMID:19483382 NCBI chr 1:80,480,718...80,486,511
Ensembl chr 1:80,480,951...80,486,508
JBrowse link
G Rps20 ribosomal protein S20 affects expression EXP Omeprazole affects the expression of RPS20 mRNA CTD PMID:19483382 NCBI chr 5:16,819,095...16,820,476
Ensembl chr 5:16,819,304...16,820,475
Ensembl chr 9:16,819,304...16,820,475
Ensembl chr 3:16,819,304...16,820,475
JBrowse link
G Rps3a ribosomal protein S3a affects expression EXP Omeprazole affects the expression of RPS3A mRNA CTD PMID:19483382 NCBI chr 2:171,524,685...171,529,054
Ensembl chr 2:171,524,500...171,529,055
JBrowse link
G Rps6 ribosomal protein S6 affects expression EXP Omeprazole affects the expression of RPS6 mRNA CTD PMID:19483382 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602
JBrowse link
G Rps8 ribosomal protein S8 affects expression EXP Omeprazole affects the expression of RPS8 mRNA CTD PMID:19483382 NCBI chr 5:130,630,362...130,632,932
Ensembl chr 5:130,629,716...130,633,268
JBrowse link
G Rras2 RAS related 2 affects expression EXP Omeprazole affects the expression of RRAS2 mRNA CTD PMID:19483382 NCBI chr 1:168,233,693...168,303,111
Ensembl chr 1:168,233,693...168,303,111
JBrowse link
G RT1-DMa RT1 class II, locus DMa affects expression ISO Omeprazole affects the expression of HLA-DMA mRNA CTD PMID:25811541 NCBI chr20:4,707,028...4,710,432
Ensembl chr20:4,707,028...4,710,432
JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 affects expression ISO Omeprazole affects the expression of HLA-G mRNA CTD PMID:25811541 NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117
JBrowse link
G RT1-S3 RT1 class Ib, locus S3 affects expression EXP Omeprazole affects the expression of RT1-S3 mRNA CTD PMID:19483382 NCBI chr20:2,670,654...2,675,411
Ensembl chr20:2,670,709...2,675,411
JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 affects expression EXP Omeprazole affects the expression of S1PR1 mRNA CTD PMID:19483382 NCBI chr 2:203,624,752...203,629,110
Ensembl chr 2:203,621,587...203,629,681
JBrowse link
G Sbspon somatomedin B and thrombospondin, type 1 domain containing affects expression EXP Omeprazole affects the expression of SBSPON mRNA CTD PMID:19483382 NCBI chr 5:3,402,763...3,433,338
Ensembl chr 5:3,402,648...3,435,420
JBrowse link
G Sdc2 syndecan 2 affects expression EXP Omeprazole affects the expression of SDC2 mRNA CTD PMID:19483382 NCBI chr 7:64,127,185...64,239,885
Ensembl chr 7:64,127,110...64,241,081
JBrowse link
G Sdhc succinate dehydrogenase complex subunit C affects expression EXP Omeprazole affects the expression of SDHC mRNA CTD PMID:19483382 NCBI chr13:83,544,652...83,565,560
Ensembl chr13:83,544,652...83,566,253
JBrowse link
G Sdhd succinate dehydrogenase complex subunit D affects expression EXP Omeprazole affects the expression of SDHD mRNA CTD PMID:19483382 NCBI chr 8:50,944,702...50,954,298
Ensembl chr 8:50,944,704...50,954,238
JBrowse link
G Sell selectin L decreases expression EXP Omeprazole results in decreased expression of SELL protein CTD PMID:17652263 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456
JBrowse link
G Serinc3 serine incorporator 3 affects expression EXP Omeprazole affects the expression of SERINC3 mRNA CTD PMID:19483382 NCBI chr 3:152,301,882...152,321,327
Ensembl chr 3:152,301,772...152,321,808
JBrowse link
G Serpina1 serpin family A member 1 affects expression EXP Omeprazole affects the expression of SERPINA1 mRNA CTD PMID:19483382 NCBI chr 6:122,866,314...122,888,339
Ensembl chr 6:122,866,312...122,888,339
JBrowse link
G Serpina10 serpin family A member 10 affects expression EXP Omeprazole affects the expression of SERPINA10 mRNA CTD PMID:19483382 NCBI chr 6:122,756,106...122,764,544
Ensembl chr 6:122,756,108...122,764,544
JBrowse link
G Serpina4 serpin family A member 4 affects expression EXP Omeprazole affects the expression of SERPINA4 mRNA CTD PMID:19483382 NCBI chr 6:122,999,970...123,009,083
Ensembl chr 6:122,999,900...123,009,082
JBrowse link
G Serpinf2 serpin family F member 2 affects expression EXP Omeprazole affects the expression of SERPINF2 mRNA CTD PMID:19483382 NCBI chr10:60,272,400...60,280,506
Ensembl chr10:60,272,400...60,281,243
JBrowse link
G Serping1 serpin family G member 1 decreases expression EXP Omeprazole results in decreased expression of SERPING1 mRNA CTD PMID:25626140 NCBI chr 3:69,842,726...69,852,583
Ensembl chr 3:69,842,739...69,852,034
JBrowse link
G Sfxn1 sideroflexin 1 affects expression EXP Omeprazole affects the expression of SFXN1 mRNA CTD PMID:19483382 NCBI chr17:10,486,250...10,522,640
Ensembl chr17:10,486,271...10,522,529
JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 affects expression EXP Omeprazole affects the expression of SHMT2 mRNA CTD PMID:19483382 NCBI chr 7:63,358,961...63,364,293
Ensembl chr 7:63,358,961...63,364,236
JBrowse link
G Slc22a1 solute carrier family 22 member 1 affects expression EXP Omeprazole affects the expression of SLC22A1 mRNA CTD PMID:19483382 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Omeprazole inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions EXP Dithioerythritol inhibits the reaction [Omeprazole inhibits the reaction [SLC22A5 protein results in increased transport of Carnitine]]; Omeprazole inhibits the reaction [SLC22A5 protein results in increased transport of Carnitine] CTD PMID:19041296 NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309
JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions ISO [Omeprazole results in decreased activity of SLC22A8 protein] which results in decreased uptake of Indican CTD PMID:36243147 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
JBrowse link
G Slc23a1 solute carrier family 23 member 1 affects expression EXP Omeprazole affects the expression of SLC23A1 mRNA CTD PMID:19483382 NCBI chr18:27,214,940...27,230,564
Ensembl chr18:27,216,281...27,230,697
JBrowse link
G Slc25a13 solute carrier family 25 member 13 affects expression EXP Omeprazole affects the expression of SLC25A13 mRNA CTD PMID:19483382 NCBI chr 4:34,179,224...34,361,912
Ensembl chr 4:34,179,224...34,361,902
JBrowse link
G Slc25a3 solute carrier family 25 member 3 affects expression EXP Omeprazole affects the expression of SLC25A3 mRNA CTD PMID:19483382 NCBI chr 7:25,611,937...25,619,401
Ensembl chr 7:25,586,725...25,667,727
JBrowse link
G Slc27a2 solute carrier family 27 member 2 affects expression EXP Omeprazole affects the expression of SLC27A2 mRNA CTD PMID:19483382 NCBI chr 3:113,804,728...113,842,208
Ensembl chr 3:113,804,728...113,842,208
JBrowse link
G Slc39a8 solute carrier family 39 member 8 affects expression EXP Omeprazole affects the expression of SLC39A8 mRNA CTD PMID:19483382 NCBI chr 2:224,171,787...224,319,326
Ensembl chr 2:224,256,654...224,319,129
JBrowse link
G Slc40a1 solute carrier family 40 member 1 decreases expression ISO Omeprazole results in decreased expression of SLC40A1 protein CTD PMID:31669099 NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481
JBrowse link
G Slc46a1 solute carrier family 46 member 1 affects expression EXP Omeprazole affects the expression of SLC46A1 mRNA CTD PMID:19483382 NCBI chr10:63,361,504...63,367,940
Ensembl chr10:63,361,486...63,368,848
JBrowse link
G Slc66a2 solute carrier family 66 member 2 affects expression EXP Omeprazole affects the expression of SLC66A2 mRNA CTD PMID:19483382 NCBI chr18:73,702,472...73,739,678
Ensembl chr18:73,702,564...73,739,676
JBrowse link
G Slc6a6 solute carrier family 6 member 6 affects expression EXP Omeprazole affects the expression of SLC6A6 mRNA CTD PMID:19483382 NCBI chr 4:124,195,186...124,268,880
Ensembl chr 4:124,195,218...124,268,875
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 increases expression ISO Omeprazole results in increased expression of SLCO1A2 mRNA CTD PMID:19118567 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO Omeprazole inhibits the reaction [Ethanol results in decreased activity of SOD1 protein] CTD PMID:28849987 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sppl2a signal peptide peptidase-like 2A affects expression EXP Omeprazole affects the expression of SPPL2A mRNA CTD PMID:19483382 NCBI chr 3:114,149,337...114,193,408
Ensembl chr 3:114,151,069...114,193,264
JBrowse link
G Srm spermidine synthase affects expression EXP Omeprazole affects the expression of SRM mRNA CTD PMID:19483382 NCBI chr 5:159,025,875...159,029,076
Ensembl chr 5:159,025,873...159,029,405
JBrowse link
G Srprb SRP receptor subunit beta affects expression EXP Omeprazole affects the expression of SRPRB mRNA CTD PMID:19483382 NCBI chr 8:103,768,685...103,782,632 JBrowse link
G Ssx2ip SSX family member 2 interacting protein affects expression EXP Omeprazole affects the expression of SSX2IP mRNA CTD PMID:19483382 NCBI chr 2:235,298,012...235,330,750
Ensembl chr 2:235,298,088...235,330,745
JBrowse link
G St3gal6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 affects expression EXP Omeprazole affects the expression of ST3GAL6 mRNA CTD PMID:19483382 NCBI chr11:42,061,282...42,121,801
Ensembl chr11:42,077,621...42,121,776
JBrowse link
G St6gal1 ST6 beta-galactoside alpha-2,6-sialyltransferase 1 affects expression EXP Omeprazole affects the expression of ST6GAL1 mRNA CTD PMID:19483382 NCBI chr11:77,526,837...77,653,474
Ensembl chr11:77,526,837...77,653,310
JBrowse link
G Suclg1 succinate-CoA ligase GDP/ADP-forming subunit alpha affects expression EXP Omeprazole affects the expression of SUCLG1 mRNA CTD PMID:19483382 NCBI chr 4:105,308,236...105,337,595
Ensembl chr 4:105,308,039...105,337,600
JBrowse link
G Surf4 surfeit 4 affects expression EXP Omeprazole affects the expression of SURF4 mRNA CTD PMID:19483382 NCBI chr 3:10,248,360...10,261,537
Ensembl chr 3:10,241,837...10,263,315
JBrowse link
G Synj2bp synaptojanin 2 binding protein affects expression EXP Omeprazole affects the expression of SYNJ2BP mRNA CTD PMID:19483382 NCBI chr 6:101,189,714...101,227,400
Ensembl chr 6:101,189,714...101,227,406
JBrowse link
G Tacr1 tachykinin receptor 1 multiple interactions ISO Omeprazole inhibits the reaction [Acids affects the localization of TACR1 protein] CTD PMID:16091555 NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO Omeprazole results in increased expression of TGFB1 protein CTD PMID:36243147 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tgfbi transforming growth factor, beta induced affects expression EXP Omeprazole affects the expression of TGFBI mRNA CTD PMID:19483382 NCBI chr17:7,955,603...7,984,903
Ensembl chr17:7,955,603...7,985,240
JBrowse link
G Thnsl2 threonine synthase-like 2 affects expression EXP Omeprazole affects the expression of THNSL2 mRNA CTD PMID:19483382 NCBI chr 4:103,112,974...103,132,122
Ensembl chr 4:103,112,963...103,132,017
JBrowse link
G Timm21 translocase of inner mitochondrial membrane 21 affects expression EXP Omeprazole affects the expression of TIMM21 mRNA CTD PMID:19483382 NCBI chr18:78,314,900...78,319,362
Ensembl chr18:78,314,909...78,319,454
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions EXP Omeprazole inhibits the reaction [Indomethacin results in increased expression of TIMP2 protein] CTD PMID:16934674 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611
JBrowse link
G Tkfc triokinase and FMN cyclase affects expression EXP Omeprazole affects the expression of TKFC mRNA CTD PMID:19483382 NCBI chr 1:207,238,230...207,253,035
Ensembl chr 1:207,236,557...207,252,737
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP Lipopolysaccharides inhibits the reaction [Omeprazole inhibits the reaction [Cisplatin results in increased expression of TLR4 protein]]; Omeprazole inhibits the reaction [Cisplatin results in increased expression of TLR4 protein] CTD PMID:32418911 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tmbim1 transmembrane BAX inhibitor motif containing 1 affects expression EXP Omeprazole affects the expression of TMBIM1 mRNA CTD PMID:19483382 NCBI chr 9:75,871,835...75,889,366
Ensembl chr 9:75,871,835...75,889,069
JBrowse link
G Tmco1 transmembrane and coiled-coil domains 1 affects expression EXP Omeprazole affects the expression of TMCO1 mRNA CTD PMID:19483382 NCBI chr13:79,460,229...79,483,557
Ensembl chr13:79,460,135...79,483,555
JBrowse link
G Tmed2 transmembrane p24 trafficking protein 2 affects expression EXP Omeprazole affects the expression of TMED2 mRNA CTD PMID:19483382 NCBI chr12:32,052,542...32,061,628
Ensembl chr12:32,052,543...32,071,903
JBrowse link
G Tmed7 transmembrane p24 trafficking protein 7 affects expression EXP Omeprazole affects the expression of TMED7 mRNA CTD PMID:19483382 NCBI chr18:39,318,564...39,325,640
Ensembl chr18:39,297,351...39,325,640
JBrowse link
G Tmem123 transmembrane protein 123 affects expression EXP Omeprazole affects the expression of TMEM123 mRNA CTD PMID:19483382 NCBI chr 8:4,922,077...4,952,228
Ensembl chr 8:4,922,098...4,952,224
JBrowse link
G Tmem97 transmembrane protein 97 affects expression EXP Omeprazole affects the expression of TMEM97 mRNA CTD PMID:19483382 NCBI chr10:63,438,228...63,447,311
Ensembl chr10:63,438,222...63,589,730
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
Omeprazole inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]
Omeprazole inhibits the reaction [Ethanol results in increased expression of TNF protein]
Omeprazole inhibits the reaction [Cisplatin results in increased expression of TNF protein]; Omeprazole inhibits the reaction [Ethanol results in decreased expression of TNF protein]
CTD PMID:19232345 PMID:25637687 PMID:26970604 PMID:30452898 PMID:32418911 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Txn1 thioredoxin 1 affects expression EXP Omeprazole affects the expression of TXN1 mRNA CTD PMID:19483382 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
JBrowse link
G Txnl1 thioredoxin-like 1 affects expression EXP Omeprazole affects the expression of TXNL1 mRNA CTD PMID:19483382 NCBI chr18:57,125,362...57,155,167
Ensembl chr18:57,125,369...57,165,266
JBrowse link
G Tyr tyrosinase multiple interactions
decreases expression
ISO Omeprazole affects the N-linked glycosylation of and results in increased degradation of TYR protein; Omeprazole inhibits the reaction [ATP7A protein results in increased activity of TYR protein]
Omeprazole results in decreased expression of TYR protein
CTD PMID:25337692 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207
JBrowse link
G Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1 affects expression EXP Omeprazole affects the expression of UBA52 mRNA CTD PMID:19483382 NCBI chr16:18,918,614...18,920,807
Ensembl chr16:18,900,616...18,920,807
JBrowse link
G Ube2n ubiquitin-conjugating enzyme E2N affects expression EXP Omeprazole affects the expression of UBE2N mRNA CTD PMID:19483382 NCBI chr 7:30,154,330...30,184,373
Ensembl chr 7:30,154,616...30,184,355
JBrowse link
G Ufd1 ubiquitin recognition factor in ER associated degradation 1 affects expression EXP Omeprazole affects the expression of UFD1 mRNA CTD PMID:19483382 NCBI chr11:82,161,618...82,185,107
Ensembl chr11:82,161,619...82,185,087
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression
affects expression
ISO
EXP
Omeprazole results in increased expression of UGT1A1 mRNA
Omeprazole affects the expression of UGT1A1 mRNA
CTD PMID:19118567 PMID:19483382 PMID:25626140 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases expression ISO Omeprazole results in increased expression of UGT1A2 mRNA; Omeprazole results in increased expression of UGT1A3 mRNA CTD PMID:19118567 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a3 UDP glycosyltransferase 1 family, polypeptide A3 increases expression ISO Omeprazole results in increased expression of UGT1A5 mRNA CTD PMID:19118567 NCBI chr 9:88,780,328...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases expression ISO Omeprazole results in increased expression of UGT1A4 mRNA CTD PMID:19118567 NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases expression
multiple interactions
EXP
ISO
Omeprazole results in increased expression of UGT1A6 mRNA
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of UGT1A6 mRNA
CTD PMID:19118567 PMID:22687989 NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases expression ISO Omeprazole results in increased expression of UGT1A9 mRNA CTD PMID:19118567 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 increases expression EXP Omeprazole results in increased expression of UGT2B1 mRNA CTD PMID:25626140 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
JBrowse link
G Uqcr11 ubiquinol-cytochrome c reductase, complex III subunit XI affects expression EXP Omeprazole affects the expression of UQCR11 mRNA CTD PMID:19483382 NCBI chr 7:9,305,042...9,309,753
Ensembl chr 7:9,305,058...9,309,750
JBrowse link
G Vnn1 vanin 1 affects expression EXP Omeprazole affects the expression of VNN1 mRNA CTD PMID:19483382 NCBI chr 1:21,537,084...21,547,395
Ensembl chr 1:21,537,094...21,547,395
JBrowse link
G Wdr26 WD repeat domain 26 affects expression EXP Omeprazole affects the expression of WDR26 mRNA CTD PMID:19483382 NCBI chr13:92,930,282...92,972,061
Ensembl chr13:92,930,285...92,977,295
JBrowse link
G Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma affects expression EXP Omeprazole affects the expression of YWHAG mRNA CTD PMID:19483382 NCBI chr12:20,744,500...20,772,828
Ensembl chr12:20,744,535...20,772,827
JBrowse link
G Zdhhc23 zinc finger DHHC-type palmitoyltransferase 23 affects expression EXP Omeprazole affects the expression of ZDHHC23 mRNA CTD PMID:19483382 NCBI chr11:56,718,702...56,735,063
Ensembl chr11:56,718,826...56,734,194
JBrowse link
G Zwint ZW10 interacting kinetochore protein affects expression EXP Omeprazole affects the expression of ZWINT mRNA CTD PMID:19483382 NCBI chr20:15,938,157...15,953,997
Ensembl chr20:15,938,157...15,953,957
JBrowse link
oxaloacetic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Got1 glutamic-oxaloacetic transaminase 1 increases expression ISO Oxaloacetic Acid results in increased expression of GOT1 mRNA CTD PMID:26811028 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
JBrowse link
G Mdh1 malate dehydrogenase 1 increases expression ISO Oxaloacetic Acid results in increased expression of MDH1 protein CTD PMID:26811028 NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925
JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II increases expression ISO Oxaloacetic Acid results in increased expression of COX2 mRNA; Oxaloacetic Acid results in increased expression of COX2 protein CTD PMID:26811028 NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha increases expression ISO Oxaloacetic Acid results in increased expression of PPARGC1A mRNA; Oxaloacetic Acid results in increased expression of PPARGC1A protein CTD PMID:23056435 PMID:26811028 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Ppargc1b PPARG coactivator 1 beta increases expression ISO Oxaloacetic Acid results in increased expression of PPARGC1B protein CTD PMID:26811028 NCBI chr18:54,758,891...54,861,103
Ensembl chr18:54,758,902...54,861,194
JBrowse link
G Pprc1 PPARG related coactivator 1 increases expression ISO Oxaloacetic Acid results in increased expression of PPRC1 mRNA; Oxaloacetic Acid results in increased expression of PPRC1 protein CTD PMID:26811028 NCBI chr 1:244,901,985...244,918,587
Ensembl chr 1:244,902,179...244,918,587
JBrowse link
G Sirt1 sirtuin 1 multiple interactions ISO Oxaloacetic Acid results in increased expression of and results in increased phosphorylation of SIRT1 protein CTD PMID:26811028 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
JBrowse link
G Tfam transcription factor A, mitochondrial increases expression ISO Oxaloacetic Acid results in increased expression of TFAM mRNA CTD PMID:26811028 NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292
JBrowse link
pantoprazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO pantoprazole results in increased expression of ABCA1 mRNA CTD PMID:20060385 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO pantoprazole promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide] CTD PMID:12702717 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO pantoprazole inhibits the reaction [ABCG2 protein affects the transport of 7-hydroxymethotrexate] CTD PMID:17032904 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G C1qa complement C1q A chain decreases expression EXP pantoprazole results in decreased expression of C1QA mRNA CTD PMID:25626140 NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534
JBrowse link
G C1qc complement C1q C chain decreases expression EXP pantoprazole results in decreased expression of C1QC mRNA CTD PMID:25626140 NCBI chr 5:149,127,412...149,130,757
Ensembl chr 5:149,127,415...149,131,017
JBrowse link
G C4bpa complement component 4 binding protein, alpha decreases expression EXP pantoprazole results in decreased expression of C4BPA mRNA CTD PMID:25626140 NCBI chr13:42,075,715...42,111,205
Ensembl chr13:42,075,717...42,111,205
JBrowse link
G C4bpb complement component 4 binding protein, beta decreases expression EXP pantoprazole results in decreased expression of C4BPB mRNA CTD PMID:25626140 NCBI chr13:42,120,798...42,131,515
Ensembl chr13:42,120,798...42,131,817
JBrowse link
G Casp3 caspase 3 multiple interactions EXP pantoprazole inhibits the reaction [Indomethacin results in increased activity of CASP3 protein] CTD PMID:18853145 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cfi complement factor I decreases expression EXP pantoprazole results in decreased expression of CFI mRNA CTD PMID:25626140 NCBI chr 2:218,389,079...218,430,565
Ensembl chr 2:218,387,990...218,430,561
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
decreases expression
EXP pantoprazole results in increased expression of CYP1A1 protein
pantoprazole results in decreased expression of CYP1A1 mRNA
CTD PMID:9152597 PMID:25626140 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression EXP pantoprazole results in increased expression of CYP1A2 mRNA; pantoprazole results in increased expression of CYP1A2 protein CTD PMID:9152597 PMID:25626140 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP pantoprazole results in increased expression of CYP2B1 protein CTD PMID:9152597 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP pantoprazole results in increased expression of CYP2B2 protein CTD PMID:9152597 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions ISO Pantoprazole inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Diclofenac] CTD PMID:15258107 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 affects response to substance
multiple interactions
decreases activity
increases metabolic processing
ISO CYP2C19 gene polymorphism affects the susceptibility to pantoprazole
pantoprazole inhibits the reaction [CYP2C19 protein results in increased hydroxylation of Mephenytoin]
pantoprazole results in decreased activity of CYP2C19 protein
CYP2C19 protein results in increased metabolism of pantoprazole
CTD PMID:8930576 PMID:15258107 PMID:20223877 PMID:21795468 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO Pantoprazole results in increased expression of and results in increased activity of CYP2E1 protein CTD PMID:36243147 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
multiple interactions
increases metabolic processing
ISO Pantoprazole results in increased expression of CYP3A4 protein
Pantoprazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]
CYP3A4 protein results in increased metabolism of Pantoprazole
CTD PMID:8930576 PMID:9744552 PMID:15258107 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Hamp hepcidin antimicrobial peptide increases expression ISO Pantoprazole results in increased expression of HAMP mRNA CTD PMID:31669099 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO pantoprazole decreases expression of JAK2 mRNA and decreases phosphorylation of JAK2 protein in gastrocnemius RGD PMID:28489606 RGD:127285673 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP pantoprazole inhibits the reaction [Indomethacin results in increased expression of MPO protein]; pantoprazole inhibits the reaction [Ketoprofen results in increased expression of MPO protein]; pantoprazole inhibits the reaction [Piroxicam results in increased expression of MPO protein] CTD PMID:16080005 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP [pantoprazole co-treated with Indomethacin] promotes the reaction [Acetic Acid results in increased expression of PCNA protein]; pantoprazole promotes the reaction [Acetic Acid results in increased expression of PCNA protein] CTD PMID:18853145 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Retsat retinol saturase increases expression EXP pantoprazole results in increased expression of RETSAT mRNA CTD PMID:25626140 NCBI chr 4:104,653,306...104,662,069
Ensembl chr 4:104,653,155...104,668,310
JBrowse link
G Serping1 serpin family G member 1 decreases expression EXP pantoprazole results in decreased expression of SERPING1 mRNA CTD PMID:25626140 NCBI chr 3:69,842,726...69,852,583
Ensembl chr 3:69,842,739...69,852,034
JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions ISO [Pantoprazole results in decreased activity of SLC22A8 protein] which results in decreased uptake of Indican CTD PMID:36243147 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression ISO Pantoprazole results in increased expression of TGFB1 protein CTD PMID:36243147 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression EXP pantoprazole results in increased expression of UGT1A1 mRNA CTD PMID:25626140 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 increases expression EXP pantoprazole results in increased expression of UGT2B1 mRNA CTD PMID:25626140 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
JBrowse link
pirenzepine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Avpr1a arginine vasopressin receptor 1A multiple interactions EXP Pirenzepine binds to and results in decreased activity of AVPR1A protein CTD PMID:11553362 NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215
JBrowse link
G Cd40 CD40 molecule multiple interactions ISO Pirenzepine inhibits the reaction [Carbachol results in increased expression of CD40 protein] CTD PMID:16879495 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 multiple interactions
affects binding
ISO
EXP
brucine affects the reaction [Pirenzepine analog binds to CHRM1 protein]; Pirenzepine inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]; Pirenzepine inhibits the reaction [Scopolamine Derivatives binds to CHRM1 protein]
Pirenzepine binds to and results in decreased activity of CHRM1 protein; Pirenzepine inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]
CTD PMID:8032910 PMID:9846649 PMID:11306684 PMID:12646291 PMID:15294002 More... NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356
JBrowse link
G Chrm5 cholinergic receptor, muscarinic 5 multiple interactions ISO Pirenzepine inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein] CTD PMID:9846649 NCBI chr 3:99,284,846...99,337,252
Ensembl chr 3:99,284,846...99,337,252
JBrowse link
G Egr1 early growth response 1 multiple interactions EXP Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of EGR1 mRNA] CTD PMID:7968354 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Egr2 early growth response 2 multiple interactions EXP Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of EGR2 mRNA] CTD PMID:7968354 NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA] CTD PMID:7968354 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA] CTD PMID:7968354 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
JBrowse link
plaunotol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Itgam integrin subunit alpha M multiple interactions ISO plaunotol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein] CTD PMID:10215738 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
JBrowse link
G Itgb2 integrin subunit beta 2 multiple interactions ISO plaunotol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGB2 protein] CTD PMID:10215738 NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600
JBrowse link
G Tnf tumor necrosis factor decreases expression ISO plaunotol results in decreased expression of TNF protein CTD PMID:10215738 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
rabeprazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C1qa complement C1q A chain decreases expression EXP Rabeprazole results in decreased expression of C1QA mRNA CTD PMID:25626140 NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534
JBrowse link
G C1qc complement C1q C chain decreases expression EXP Rabeprazole results in decreased expression of C1QC mRNA CTD PMID:25626140 NCBI chr 5:149,127,412...149,130,757
Ensembl chr 5:149,127,415...149,131,017
JBrowse link
G C4bpa complement component 4 binding protein, alpha decreases expression EXP Rabeprazole results in decreased expression of C4BPA mRNA CTD PMID:25626140 NCBI chr13:42,075,715...42,111,205
Ensembl chr13:42,075,717...42,111,205
JBrowse link
G C4bpb complement component 4 binding protein, beta decreases expression EXP Rabeprazole results in decreased expression of C4BPB mRNA CTD PMID:25626140 NCBI chr13:42,120,798...42,131,515
Ensembl chr13:42,120,798...42,131,817
JBrowse link
G Cfi complement factor I decreases expression EXP Rabeprazole results in decreased expression of CFI mRNA CTD PMID:25626140 NCBI chr 2:218,389,079...218,430,565
Ensembl chr 2:218,387,990...218,430,561
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
decreases activity
ISO
EXP
Rabeprazole results in increased expression of CYP1A1 mRNA; Rabeprazole results in increased expression of CYP1A1 protein
Rabeprazole results in decreased activity of CYP1A1 protein
CTD PMID:9041675 PMID:12623754 PMID:25626140 PMID:33814510 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO
EXP
Rabeprazole results in increased expression of CYP1A2 mRNA CTD PMID:12623754 PMID:25626140 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Rabeprazole results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 multiple interactions
affects response to substance
ISO CYP2C19 affects the susceptibility to [Tacrolimus co-treated with Rabeprazole]
CYP2C19 gene affects the susceptibility to Rabeprazole
CTD PMID:15903128 PMID:17377957 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions ISO CYP3A5 affects the susceptibility to [Tacrolimus co-treated with Rabeprazole] CTD PMID:17377957 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Hamp hepcidin antimicrobial peptide increases expression ISO Rabeprazole results in increased expression of HAMP mRNA CTD PMID:31669099 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
JBrowse link
G Pomc proopiomelanocortin increases expression ISO Rabeprazole results in increased expression of POMC protein CTD PMID:16524691 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Retsat retinol saturase increases expression EXP Rabeprazole results in increased expression of RETSAT mRNA CTD PMID:25626140 NCBI chr 4:104,653,306...104,662,069
Ensembl chr 4:104,653,155...104,668,310
JBrowse link
G Serping1 serpin family G member 1 decreases expression EXP Rabeprazole results in decreased expression of SERPING1 mRNA CTD PMID:25626140 NCBI chr 3:69,842,726...69,852,583
Ensembl chr 3:69,842,739...69,852,034
JBrowse link
G Slc18a2 solute carrier family 18 member A2 multiple interactions EXP Rabeprazole promotes the reaction [SLC18A2 protein results in increased secretion of Histamine] CTD PMID:14642791 NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Rabeprazole inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression EXP Rabeprazole results in increased expression of UGT1A1 mRNA CTD PMID:25626140 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 increases expression EXP Rabeprazole results in increased expression of UGT2B1 mRNA CTD PMID:25626140 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
JBrowse link
ranitidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions ISO
EXP
Ranitidine binds to and results in decreased activity of ACHE protein; Ranitidine inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]
Ranitidine affects the reaction [Paraoxon results in decreased activity of ACHE protein]
CTD PMID:15669026 PMID:15669039 PMID:16193528 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Ackr3 atypical chemokine receptor 3 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ACKR3 mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ACKR3 mRNA]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of ACKR3 mRNA] CTD PMID:16401727 PMID:16415329 NCBI chr 9:90,799,682...90,811,246
Ensembl chr 9:90,799,686...90,811,237
JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ADAMTS1 mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ADAMTS1 mRNA]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of ADAMTS1 mRNA] CTD PMID:16401727 PMID:16415329 NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103
JBrowse link
G Alb albumin multiple interactions EXP [Ranitidine co-treated with Diclofenac] results in decreased expression of ALB protein; Quercetin inhibits the reaction [[Ranitidine co-treated with Diclofenac] results in decreased expression of ALB protein] CTD PMID:28400101 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Aldoa aldolase, fructose-bisphosphate A multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ALDOA mRNA CTD PMID:16415329 NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182
JBrowse link
G Amotl2 angiomotin like 2 multiple interactions EXP Ranitidine inhibits the reaction [Lipopolysaccharides results in increased expression of AMOTL2 mRNA] CTD PMID:16415329 NCBI chr 8:103,303,368...103,319,161
Ensembl chr 8:103,302,992...103,318,910
JBrowse link
G Arhgef11 Rho guanine nucleotide exchange factor 11 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ARHGEF11 mRNA CTD PMID:16415329 NCBI chr 2:173,074,383...173,195,962
Ensembl chr 2:173,074,368...173,196,010
JBrowse link
G Atf3 activating transcription factor 3 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ATF3 mRNA; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of ATF3 mRNA] CTD PMID:16401727 PMID:16415329 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ATP1B1 mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ATP1B1 mRNA]; Ranitidine inhibits the reaction [Lipopolysaccharides results in decreased expression of ATP1B1 mRNA] CTD PMID:16401727 PMID:16415329 NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO
EXP
Ranitidine inhibits the reaction [Rotenone results in increased expression of BAX protein]
Ranitidine inhibits the reaction [Aspirin results in increased expression of BAX protein]
CTD PMID:19723537 PMID:30885738 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bche butyrylcholinesterase multiple interactions ISO Ranitidine binds to and results in decreased activity of BCHE protein; Ranitidine inhibits the reaction [Paraoxon results in decreased activity of BCHE protein] CTD PMID:15669026 PMID:16193528 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO Ranitidine inhibits the reaction [Rotenone results in decreased expression of BCL2 protein] CTD PMID:19723537 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bhlhe40 basic helix-loop-helix family, member e40 multiple interactions EXP Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of BHLHE40 mRNA] CTD PMID:16415329 NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774
JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions EXP Ranitidine inhibits the reaction [Lipopolysaccharides results in decreased expression of BMP2 mRNA] CTD PMID:16415329 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
JBrowse link
G Bnip3 BCL2 interacting protein 3 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of BNIP3 mRNA CTD PMID:16401727 PMID:16415329 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
JBrowse link
G Btg2 BTG anti-proliferation factor 2 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of BTG2 mRNA; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of BTG2 mRNA] CTD PMID:16401727 PMID:16415329 NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
JBrowse link
G Calca calcitonin-related polypeptide alpha increases expression ISO Ranitidine results in increased expression of CALCA protein CTD PMID:12495560 NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
Ranitidine inhibits the reaction [Rotenone results in increased cleavage of and results in increased activity of CASP3 protein]
Ranitidine inhibits the reaction [Aspirin results in increased expression of CASP3 mRNA]; Ranitidine inhibits the reaction [Aspirin results in increased expression of CASP3 protein]; Ranitidine inhibits the reaction [Indomethacin results in increased expression of CASP3 mRNA]; Ranitidine inhibits the reaction [Indomethacin results in increased expression of CASP3 protein]
CTD PMID:19723537 PMID:28648817 PMID:29523851 PMID:30580614 PMID:30885738 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Ranitidine inhibits the reaction [Rotenone results in increased cleavage of CASP9 protein] CTD PMID:19723537 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions EXP Ranitidine inhibits the reaction [Indomethacin results in decreased activity of CAT protein]; Ranitidine inhibits the reaction [Indomethacin results in increased activity of CAT protein] CTD PMID:16169175 PMID:16397915 PMID:17895592 PMID:18087811 PMID:18726076 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccnl1 cyclin L1 multiple interactions EXP Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of CCNL1 mRNA] CTD PMID:16415329 NCBI chr 2:150,184,865...150,199,524
Ensembl chr 2:150,184,798...150,197,368
JBrowse link
G Cd80 Cd80 molecule multiple interactions ISO Ranitidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein]] CTD PMID:12538815 NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030
JBrowse link
G Cdk6 cyclin-dependent kinase 6 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in decreased expression of CDK6 mRNA CTD PMID:16415329 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
JBrowse link
G Crem cAMP responsive element modulator multiple interactions EXP Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of CREM mRNA] CTD PMID:16415329 NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989
JBrowse link
G Csf3 colony stimulating factor 3 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of CSF3 mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of CSF3 mRNA] CTD PMID:16401727 NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603
JBrowse link
G Ctsl cathepsin L multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of CTSL mRNA CTD PMID:16415329 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases expression EXP Ranitidine results in decreased expression of CXCL1 protein CTD PMID:12023551 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of CXCL2 mRNA; [Ranitidine co-treated with Lipopolysaccharides] results in increased expression of CXCL2 protein; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of CXCL2 mRNA]; Heparin inhibits the reaction [Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of CXCL2 protein]]; Pentoxifylline inhibits the reaction [[Ranitidine co-treated with Lipopolysaccharides] results in increased expression of CXCL2 protein]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of CXCL2 mRNA]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of CXCL2 protein] CTD PMID:16401727 PMID:16415329 PMID:17698507 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Ddah1 dimethylarginine dimethylaminohydrolase 1 multiple interactions EXP Ranitidine inhibits the reaction [Indomethacin results in decreased expression of DDAH1 mRNA] CTD PMID:29523851 NCBI chr 2:234,667,499...234,800,322
Ensembl chr 2:234,667,491...234,799,339
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of DDIT4 mRNA CTD PMID:16415329 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
JBrowse link
G Dio3 iodothyronine deiodinase 3 multiple interactions EXP Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of DIO3 mRNA] CTD PMID:16415329 NCBI chr 6:129,285,747...129,287,608
Ensembl chr 6:129,285,749...129,286,660
JBrowse link
G Dusp1 dual specificity phosphatase 1 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of DUSP1 mRNA CTD PMID:16415329 NCBI chr10:16,680,478...16,683,275 JBrowse link
G Efna1 ephrin A1 multiple interactions EXP Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of EFNA1 mRNA] CTD PMID:16415329 NCBI chr 2:174,681,676...174,689,061
Ensembl chr 2:174,681,682...174,690,866
JBrowse link
G Egfl7 EGF-like-domain, multiple 7 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in decreased expression of EGFL7 mRNA CTD PMID:16415329 NCBI chr 3:9,404,622...9,416,879
Ensembl chr 3:9,407,520...9,416,879
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions EXP Ranitidine inhibits the reaction [Indomethacin results in increased expression of EGFR mRNA] CTD PMID:29523851 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of EGLN3 mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of EGLN3 mRNA] CTD PMID:16401727 PMID:16415329 NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766
JBrowse link
G Egr1 early growth response 1 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of EGR1 mRNA; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of EGR1 mRNA] CTD PMID:16401727 PMID:16415329 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions EXP Ranitidine inhibits the reaction [Lipopolysaccharides results in decreased expression of F3 mRNA] CTD PMID:16415329 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
JBrowse link
G Fgf23 fibroblast growth factor 23 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of FGF23 mRNA CTD PMID:16415329 NCBI chr 4:159,914,267...159,923,821
Ensembl chr 4:159,914,272...159,923,821
JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 affects metabolic processing ISO FMO3 protein affects the metabolism of Ranitidine CTD PMID:15286053 NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of FOS mRNA CTD PMID:16415329 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit multiple interactions EXP Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of FOSL2 mRNA] CTD PMID:16415329 NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034
JBrowse link
G Foxq1 forkhead box Q1 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of FOXQ1 mRNA CTD PMID:16415329 NCBI chr17:32,912,744...32,915,377
Ensembl chr17:32,912,744...32,915,377
Ensembl chr17:32,912,744...32,915,377
JBrowse link
G Fst follistatin multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of FST mRNA; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of FST mRNA] CTD PMID:16415329 NCBI chr 2:46,123,260...46,130,584
Ensembl chr 2:46,123,439...46,130,571
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of GADD45A mRNA CTD PMID:16415329 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gast gastrin affects expression
multiple interactions
ISO
EXP
Ranitidine affects the expression of GAST protein
Ranitidine inhibits the reaction [GAST protein modified form results in increased secretion of Acids]
CTD PMID:2470453 PMID:12503773 NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of GOT1 mRNA CTD PMID:16415329 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
JBrowse link
G Gzmb granzyme B multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of GZMB mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of GZMB mRNA] CTD PMID:16401727 NCBI chr15:30,343,352...30,346,814
Ensembl chr15:30,173,603...30,346,814
JBrowse link
G H2ac25 H2A clustered histone 25 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of H2A mRNA CTD PMID:16415329 NCBI chr10:43,733,702...43,735,254
Ensembl chr10:43,733,668...43,744,874
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP Ranitidine inhibits the reaction [Indomethacin results in decreased expression of HMOX1 mRNA]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA] CTD PMID:16415329 PMID:30580614 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in decreased expression of HNF4A mRNA CTD PMID:16415329 NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320
JBrowse link
G Homer1 homer scaffold protein 1 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of HOMER1 mRNA CTD PMID:16415329 NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785
JBrowse link
G Hoxa5 homeo box A5 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of HOXA5 mRNA CTD PMID:16415329 NCBI chr 4:81,302,341...81,306,234
Ensembl chr 4:81,302,353...81,306,234
JBrowse link
G Hrh2 histamine receptor H 2 multiple interactions
decreases activity
ISO
EXP
[Ranitidine binds to and results in decreased activity of HRH2 protein] which affects the susceptibility to Metformin; Ranitidine binds to and results in decreased activity of HRH2 protein; Ranitidine inhibits the reaction [tiotidine binds to HRH2 protein]
Ranitidine binds to and results in decreased activity of HRH2 protein; Ranitidine inhibits the reaction [Dimaprit binds to and results in increased activity of HRH2 protein]; Ranitidine inhibits the reaction [Melitten results in increased activity of HRH2 protein]
Ranitidine results in decreased activity of HRH2 protein
CTD PMID:6106871 PMID:6835285 PMID:7512805 PMID:9681472 PMID:9819373 More... NCBI chr17:10,366,004...10,407,791
Ensembl chr17:10,368,298...10,407,631
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of HSPA1A mRNA CTD PMID:16415329 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
JBrowse link
G Hspb8 heat shock protein family B (small) member 8 multiple interactions EXP Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of HSPB8 mRNA] CTD PMID:16415329 NCBI chr12:40,176,405...40,205,002
Ensembl chr12:40,176,532...40,191,185
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]] CTD PMID:11752121 PMID:12538815 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Id2 inhibitor of DNA binding 2 multiple interactions EXP Ranitidine inhibits the reaction [Lipopolysaccharides results in decreased expression of ID2 mRNA] CTD PMID:16415329 NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
JBrowse link
G Id4 inhibitor of DNA binding 4 multiple interactions EXP Ranitidine inhibits the reaction [Lipopolysaccharides results in decreased expression of ID4 mRNA] CTD PMID:16415329 NCBI chr17:16,389,387...16,391,956
Ensembl chr17:16,389,387...16,392,470
JBrowse link
G Ifng interferon gamma multiple interactions ISO
EXP
Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]]
[IFNG protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Ranitidine; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of IFNG mRNA]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of IFNG protein]
CTD PMID:10569698 PMID:11752121 PMID:16415329 PMID:17698507 PMID:19362101 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Ifrd1 interferon-related developmental regulator 1 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of IFRD1 mRNA CTD PMID:16415329 NCBI chr 6:57,269,395...57,317,833
Ensembl chr 6:57,269,384...57,288,990
JBrowse link
G Igsf10 immunoglobulin superfamily, member 10 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of IGSF10 mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of IGSF10 mRNA] CTD PMID:16401727 NCBI chr 2:143,575,710...143,605,044
Ensembl chr 2:143,576,070...143,604,773
JBrowse link
G Il10 interleukin 10 multiple interactions EXP
ISO
Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of IL10 protein]
Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]
CTD PMID:11752121 PMID:17698507 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il12a interleukin 12A multiple interactions ISO Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]; Ranitidine inhibits the reaction [Histamine results in decreased expression of IL12A protein] CTD PMID:9819373 PMID:11752121 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
JBrowse link
G Il12b interleukin 12B multiple interactions ISO Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]; Ranitidine inhibits the reaction [Histamine results in decreased expression of IL12B protein] CTD PMID:9819373 PMID:11752121 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
JBrowse link
G Il18 interleukin 18 multiple interactions ISO Ranitidine inhibits the reaction [Cimetidine results in increased expression of IL18 protein]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]] CTD PMID:11752121 PMID:16723495 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1a interleukin 1 alpha multiple interactions EXP [IFNG protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Ranitidine CTD PMID:19362101 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
EXP Pentoxifylline inhibits the reaction [Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; Ranitidine inhibits the reaction [Capsaicin results in increased expression of IL1B protein]; Ranitidine inhibits the reaction [Indomethacin results in increased expression of IL1B mRNA]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein]
Ranitidine results in increased expression of IL1B protein
CTD PMID:15265675 PMID:17698507 PMID:30580614 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il4 interleukin 4 multiple interactions EXP Ranitidine inhibits the reaction [Indomethacin results in increased expression of IL4 protein] CTD PMID:29523851 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of IL6 mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of IL6 mRNA]; Pentoxifylline inhibits the reaction [Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; Ranitidine inhibits the reaction [Capsaicin results in increased expression of IL6 protein]; Ranitidine inhibits the reaction [Indomethacin results in increased expression of IL6 protein]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:15265675 PMID:16401727 PMID:16415329 PMID:17698507 PMID:28648817 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Inhbe inhibin subunit beta E multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in decreased expression of INHBE mRNA CTD PMID:16415329 NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172
JBrowse link
G Insig1 insulin induced gene 1 multiple interactions EXP Ranitidine inhibits the reaction [Lipopolysaccharides results in decreased expression of INSIG1 mRNA] CTD PMID:16415329 NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952
JBrowse link
G Insig2 insulin induced gene 2 multiple interactions EXP Ranitidine inhibits the reaction [Lipopolysaccharides results in decreased expression of INSIG2 mRNA] CTD PMID:16415329 NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923
JBrowse link
G Irs2 insulin receptor substrate 2 multiple interactions EXP Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of IRS2 mRNA] CTD PMID:16415329 NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482
JBrowse link
G Itpkc inositol-trisphosphate 3-kinase C multiple interactions EXP Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of ITPKC mRNA] CTD PMID:16415329 NCBI chr 1:82,500,957...82,522,533
Ensembl chr 1:82,500,957...82,522,779
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of JUN mRNA] CTD PMID:16415329 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Klf4 KLF transcription factor 4 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of KLF4 mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of KLF4 mRNA] CTD PMID:16401727 PMID:16415329 NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602
JBrowse link
G Klf6 KLF transcription factor 6 multiple interactions EXP Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of KLF6 mRNA] CTD PMID:16415329 NCBI chr17:64,539,456...64,548,451
Ensembl chr17:64,531,463...64,588,570
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Ranitidine inhibits the reaction [Rotenone results in increased phosphorylation of MAPK1 protein] CTD PMID:19723537 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Ranitidine inhibits the reaction [Rotenone results in increased phosphorylation of MAPK3 protein] CTD PMID:19723537 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 increases expression
multiple interactions
EXP Ranitidine results in increased expression of MAPKAPK2 mRNA
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of MAPKAPK2 mRNA
CTD PMID:16401727 PMID:16415329 NCBI chr13:42,513,762...42,560,061
Ensembl chr13:42,513,762...42,560,457
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP Ranitidine inhibits the reaction [Ethanol results in increased secretion of and results in increased activity of MMP9 protein]; Ranitidine inhibits the reaction [Indomethacin results in increased expression of MMP9 protein] CTD PMID:17603938 PMID:29523851 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpo myeloperoxidase decreases expression
multiple interactions
EXP Ranitidine results in decreased expression of MPO protein
Ranitidine inhibits the reaction [Aspirin results in increased expression of MPO protein]; Ranitidine inhibits the reaction [Indomethacin results in increased activity of MPO protein]
CTD PMID:12023551 PMID:16169175 PMID:17895592 PMID:18726076 PMID:28648817 More... NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions EXP Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of MYC mRNA] CTD PMID:16415329 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nedd4l NEDD4 like E3 ubiquitin protein ligase multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of NEDD4L mRNA CTD PMID:16415329 NCBI chr18:58,393,759...58,726,709
Ensembl chr18:58,393,509...58,723,137
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP Ranitidine inhibits the reaction [Indomethacin results in decreased expression of NFE2L2 mRNA] CTD PMID:28648817 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Ngf nerve growth factor multiple interactions EXP Ranitidine inhibits the reaction [Capsaicin results in increased expression of NGF protein] CTD PMID:15265675 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Noct nocturnin multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of NOCT mRNA CTD PMID:16415329 NCBI chr 2:135,271,189...135,291,407
Ensembl chr 2:135,271,189...135,291,400
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Ranitidine inhibits the reaction [Indomethacin results in increased activity of NOS2 protein] CTD PMID:16169175 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP Ranitidine inhibits the reaction [Indomethacin results in decreased expression of NQO1 protein] CTD PMID:30580614 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of NR4A1 mRNA CTD PMID:16415329 NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of NUPR1 mRNA CTD PMID:16415329 NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281
JBrowse link
G P4ha1 prolyl 4-hydroxylase subunit alpha 1 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of P4HA1 mRNA CTD PMID:16415329 NCBI chr20:27,302,046...27,352,098
Ensembl chr20:27,302,141...27,352,786
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Ranitidine inhibits the reaction [Rotenone results in increased cleavage of PARP1 protein] CTD PMID:19723537 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pfkl phosphofructokinase, liver type multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of PFKL mRNA CTD PMID:16415329 NCBI chr20:10,664,285...10,686,324
Ensembl chr20:10,664,272...10,686,315
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A multiple interactions EXP Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of PPP1R15A mRNA] CTD PMID:16415329 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
JBrowse link
G Preb prolactin regulatory element binding multiple interactions EXP Ranitidine inhibits the reaction [Lipopolysaccharides results in increased expression of PREB mRNA] CTD PMID:16415329 NCBI chr 6:25,418,805...25,422,594
Ensembl chr 6:25,418,776...25,422,590
JBrowse link
G Prl prolactin affects expression
increases secretion
ISO Ranitidine affects the expression of PRL protein
Ranitidine results in increased secretion of PRL protein
CTD PMID:7878608 PMID:9037573 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of PTGS2 mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of PTGS2 mRNA]; Ranitidine inhibits the reaction [Indomethacin results in increased expression of PTGS2 mRNA]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] CTD PMID:16401727 PMID:16415329 PMID:29523851 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Pvr PVR cell adhesion molecule multiple interactions EXP Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of PVR mRNA] CTD PMID:16415329 NCBI chr 1:79,561,294...79,576,700
Ensembl chr 1:79,546,879...79,576,715
JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of RAC1 mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of RAC1 mRNA] CTD PMID:16401727 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Ranitidine inhibits the reaction [Indomethacin results in increased expression of RELA mRNA]; Ranitidine inhibits the reaction [Indomethacin results in increased expression of RELA protein] CTD PMID:28648817 PMID:30580614 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Ren renin affects activity ISO Ranitidine affects the activity of REN protein CTD PMID:1972605 NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
JBrowse link
G Rgs2 regulator of G-protein signaling 2 multiple interactions EXP Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of RGS2 mRNA] CTD PMID:16415329 NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385
JBrowse link
G Rgs4 regulator of G-protein signaling 4 multiple interactions EXP Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of RGS4 mRNA] CTD PMID:16415329 NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068
JBrowse link
G Rhob ras homolog family member B multiple interactions EXP Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of ARHB mRNA] CTD PMID:16415329 NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of SERPINE1 mRNA; Heparin inhibits the reaction [Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 protein]]; Pentoxifylline inhibits the reaction [Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 protein]]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 mRNA]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 protein] CTD PMID:16401727 PMID:16415329 PMID:17698507 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Sh2b2 SH2B adaptor protein 2 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of APS mRNA CTD PMID:16415329 NCBI chr12:20,427,057...20,456,845
Ensembl chr12:20,429,043...20,456,844
JBrowse link
G Shank3 SH3 and multiple ankyrin repeat domains 3 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in decreased expression of SHANK3 mRNA CTD PMID:16415329 NCBI chr 7:120,568,707...120,630,796
Ensembl chr 7:120,570,402...120,630,374
JBrowse link
G Sik1 salt-inducible kinase 1 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of SIK1 mRNA; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SIK1 mRNA] CTD PMID:16415329 NCBI chr20:9,949,407...9,959,036
Ensembl chr20:9,947,396...9,958,991
JBrowse link
G Slc16a6 solute carrier family 16, member 6 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of SLC16A6 mRNA CTD PMID:16415329 NCBI chr10:94,424,377...94,447,482
Ensembl chr10:94,426,244...94,448,779
JBrowse link
G Slc20a1 solute carrier family 20 member 1 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of SLC20A1 mRNA CTD PMID:16415329 NCBI chr 3:116,427,095...116,441,049
Ensembl chr 3:116,427,098...116,441,051
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions
increases uptake
affects transport
ISO
EXP
Ranitidine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Ranitidine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
SLC22A1 protein results in increased uptake of Ranitidine
SLC22A1 protein affects the transport of Ranitidine
CTD PMID:16006492 PMID:16141367 PMID:16263091 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
JBrowse link
G Slc22a2 solute carrier family 22 member 2 increases uptake
multiple interactions
ISO
EXP
SLC22A2 protein results in increased uptake of Ranitidine
Ranitidine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Ranitidine inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
CTD PMID:16006492 PMID:16141367 PMID:16263091 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc22a3 solute carrier family 22 member 3 multiple interactions ISO Ranitidine inhibits the reaction [SLC22A3 protein affects the transport of 1-Methyl-4-phenylpyridinium]; Ranitidine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Ranitidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:16141367 PMID:16263091 NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
JBrowse link
G Slc22a6 solute carrier family 22 member 6 increases uptake ISO SLC22A6 protein results in increased uptake of Ranitidine CTD PMID:16006492 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
JBrowse link
G Slc22a7 solute carrier family 22 member 7 increases uptake ISO SLC22A7 protein results in increased uptake of Ranitidine CTD PMID:16006492 NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921
JBrowse link
G Slc22a8 solute carrier family 22 member 8 increases uptake
multiple interactions
ISO
EXP
SLC22A8 protein results in increased uptake of Ranitidine
Penicillin G inhibits the reaction [SLC22A8 protein results in increased uptake of Ranitidine]; Probenecid promotes the reaction [SLC22A8 protein results in increased uptake of Ranitidine]; Ranitidine inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]
CTD PMID:15319347 PMID:16006492 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions EXP Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SLC2A1 mRNA] CTD PMID:16415329 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Slc38a2 solute carrier family 38, member 2 multiple interactions EXP Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SLC38A2 mRNA] CTD PMID:16415329 NCBI chr 7:127,851,267...127,863,482
Ensembl chr 7:127,851,267...127,863,436
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Ranitidine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Ranitidine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:22419765 NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904
JBrowse link
G Slc5a3 solute carrier family 5 member 3 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of SLC5A3 mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of SLC5A3 mRNA] CTD PMID:16401727 NCBI chr11:31,313,847...31,316,293
Ensembl chr11:31,295,476...31,318,883
JBrowse link
G Slk STE20-like kinase multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of SLK mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of SLK mRNA] CTD PMID:16401727 NCBI chr 1:246,473,712...246,529,643
Ensembl chr 1:246,473,712...246,526,530
JBrowse link
G Sphk1 sphingosine kinase 1 multiple interactions EXP Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SPHK1 mRNA] CTD PMID:16415329 NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240
JBrowse link
G Tac1 tachykinin, precursor 1 increases expression ISO Ranitidine results in increased expression of TAC1 protein CTD PMID:12495560 NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
JBrowse link
G Tfrc transferrin receptor multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of TFRC mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of TFRC mRNA] CTD PMID:16401727 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]
[IFNG protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Ranitidine; Ranitidine inhibits the reaction [Aspirin results in increased expression of TNF protein]; Ranitidine inhibits the reaction [Capsaicin results in increased expression of TNF protein]; Ranitidine inhibits the reaction [Indomethacin results in increased expression of TNF protein]; Ranitidine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]
CTD PMID:11752121 PMID:12023551 PMID:12538815 PMID:15265675 PMID:17698507 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfaip6 TNF alpha induced protein 6 multiple interactions EXP Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of TNFAIP6 mRNA] CTD PMID:16415329 NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649
JBrowse link
G Tnfrsf12a TNF receptor superfamily member 12A multiple interactions EXP Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of TNFRSF12A mRNA] CTD PMID:16415329 NCBI chr10:12,707,077...12,709,071
Ensembl chr10:12,689,890...12,709,045
JBrowse link
G Tpm3 tropomyosin 3 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of TPM3 mRNA CTD PMID:16415329 NCBI chr 2:175,517,198...175,545,014
Ensembl chr 2:175,517,226...175,545,013
JBrowse link
G Trak2 trafficking kinesin protein 2 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of TRAK2 mRNA CTD PMID:16415329 NCBI chr 9:60,348,531...60,414,036
Ensembl chr 9:60,350,012...60,413,996
JBrowse link
G Ube2b ubiquitin-conjugating enzyme E2B multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of UBE2B mRNA CTD PMID:16415329 NCBI chr10:36,248,434...36,263,379
Ensembl chr10:36,248,438...36,264,665
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of VEGFA mRNA CTD PMID:16415329 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Zbtb10 zinc finger and BTB domain containing 10 multiple interactions EXP [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ZBTB10 mRNA CTD PMID:16415329 NCBI chr 2:92,475,254...92,509,892
Ensembl chr 2:92,479,014...92,512,515
JBrowse link
G Zfyve27 zinc finger FYVE-type containing 27 multiple interactions EXP Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of ZFYVE27 mRNA] CTD PMID:16415329 NCBI chr 1:240,979,831...241,003,193
Ensembl chr 1:240,979,842...241,003,193
JBrowse link
SAICAR term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pkm pyruvate kinase M1/2 multiple interactions ISO Glucose deficiency promotes the reaction [SAICAR binds to and results in increased activity of PKM protein] CTD PMID:23086999 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
JBrowse link
sarpogrelate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acat1 acetyl-CoA acetyltransferase 1 multiple interactions ISO sarpogrelate inhibits the reaction [Serotonin results in increased expression of ACAT1 protein]; sarpogrelate metabolite inhibits the reaction [Serotonin results in increased expression of ACAT1 protein] CTD PMID:16157345 NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO sarpogrelate results in increased expression of ADIPOQ protein CTD PMID:18235151 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Adra1a adrenoceptor alpha 1A multiple interactions ISO sarpogrelate inhibits the reaction [Prazosin binds to ADRA1A protein] CTD PMID:11937776 NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500
JBrowse link
G Adra1b adrenoceptor alpha 1B multiple interactions ISO sarpogrelate inhibits the reaction [Prazosin binds to ADRA1B protein] CTD PMID:11937776 NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919
JBrowse link
G Adra1d adrenoceptor alpha 1D multiple interactions ISO sarpogrelate inhibits the reaction [Prazosin binds to ADRA1D protein] CTD PMID:11937776 NCBI chr 3:118,793,356...118,809,354
Ensembl chr 3:118,793,346...118,809,354
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO [sarpogrelate results in increased activity of AKT1 protein] inhibits the reaction [Serotonin results in increased ubiquitination of and results in increased degradation of IRS1 protein] CTD PMID:22975078 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 affects expression EXP sarpogrelate affects the expression of ATP2A2 mRNA; sarpogrelate affects the expression of ATP2A2 protein CTD PMID:18088389 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased expression of BAX protein]; Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased expression of BAX protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]]
Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]]
CTD PMID:34560070 PMID:35202708 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]; sarpogrelate inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]]
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]; sarpogrelate inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]]
CTD PMID:34560070 PMID:35202708 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]]
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]]
CTD PMID:34560070 PMID:35202708 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 multiple interactions ISO [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP9 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP9 protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP9 protein]]
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]; Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP9 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP9 protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP9 protein]]
CTD PMID:34560070 PMID:35202708 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
decreases expression
ISO sarpogrelate inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CCL2 protein]
sarpogrelate results in decreased expression of CCL2 protein
CTD PMID:18235151 PMID:26824242 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity
multiple interactions
ISO sarpogrelate metabolite results in decreased activity of CYP2D6 protein; sarpogrelate results in decreased activity of CYP2D6 protein
sarpogrelate inhibits the reaction [CYP2D6 protein results in decreased methylation of Dextromethorphan]; sarpogrelate metabolite inhibits the reaction [CYP2D6 protein results in decreased methylation of Dextromethorphan]
CTD PMID:24167220 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Ddc dopa decarboxylase multiple interactions ISO sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of DDC mRNA]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of DDC protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased expression of DDC protein]
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in increased expression of DDC mRNA]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of DDC mRNA]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of DDC protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased expression of DDC protein]
CTD PMID:34560070 PMID:35202708 NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208
JBrowse link
G Dnm1l dynamin 1-like multiple interactions ISO Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of DNM1L protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of DNM1L protein]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of DNM1L protein]]
Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of DNM1L protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of DNM1L protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in increased expression of DNM1L protein]]
CTD PMID:35202708 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
JBrowse link
G Fabp1 fatty acid binding protein 1 multiple interactions ISO sarpogrelate inhibits the reaction [Oxygen deficiency results in increased expression of FABP1 protein] CTD PMID:24107419 NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
JBrowse link
G Fis1 fission, mitochondrial 1 multiple interactions ISO Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of FIS1 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of FIS1 protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in increased expression of FIS1 protein]]
Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of FIS1 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of FIS1 protein]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of FIS1 protein]]
CTD PMID:35202708 NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]] CTD PMID:35202708 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B multiple interactions EXP sarpogrelate inhibits the reaction [Iodocyanopindolol binds to HTR1B protein]; sarpogrelate metabolite inhibits the reaction [Iodocyanopindolol binds to HTR1B protein] CTD PMID:8937629 NCBI chr 8:82,513,572...82,534,670
Ensembl chr 8:82,517,360...82,534,549
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions
affects binding
ISO
EXP
sarpogrelate binds to and results in decreased activity of HTR2A protein; sarpogrelate binds to and results in decreased activity of HTR2A protein mutant form; sarpogrelate metabolite binds to and results in decreased activity of HTR2A protein
sarpogrelate binds to HTR2A protein; sarpogrelate metabolite binds to HTR2A protein
CTD PMID:8937629 PMID:16974069 PMID:17031071 PMID:19672037 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C affects binding ISO sarpogrelate binds to HTR2C protein CTD PMID:16880620 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO sarpogrelate inhibits the reaction [Glucose results in increased expression of ICAM1 protein] CTD PMID:23111892 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Il18 interleukin 18 decreases expression ISO sarpogrelate results in decreased expression of IL18 protein CTD PMID:15080020 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased secretion of IL1B protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased secretion of IL1B protein]
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased expression of IL1B protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased expression of IL1B protein]
CTD PMID:34560070 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO sarpogrelate inhibits the reaction [Serotonin results in increased expression of and results in increased secretion of IL6 protein] CTD PMID:11076827 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO [sarpogrelate results in increased activity of AKT1 protein] inhibits the reaction [Serotonin results in increased ubiquitination of and results in increased degradation of IRS1 protein] CTD PMID:22975078 NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
JBrowse link
G Kdr kinase insert domain receptor multiple interactions ISO sarpogrelate inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of KDR protein] CTD PMID:27097221 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
JBrowse link
G Maoa monoamine oxidase A multiple interactions ISO [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in increased expression of MAOA mRNA]; [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased expression of MAOA protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of MAOA protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of MAOA mRNA]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of MAOA protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased expression of MAOA protein]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of MAOA protein]] CTD PMID:34560070 PMID:35202708 NCBI chr  X:6,032,172...6,098,308
Ensembl chr  X:6,030,795...6,099,593
JBrowse link
G Mfn1 mitofusin 1 multiple interactions ISO [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN1 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN1 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN1 protein]
Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN1 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN1 protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN1 protein]]
CTD PMID:35202708 NCBI chr 2:115,313,380...115,359,651
Ensembl chr 2:115,313,401...115,359,640
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions EXP sarpogrelate inhibits the reaction [Oxygen deficiency results in increased expression of MMP13 mRNA] CTD PMID:25931318 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
JBrowse link
G Mt-atp6 mitochondrially encoded ATP synthase membrane subunit 6 multiple interactions ISO Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ATP6 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ATP6 protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in decreased expression of ATP6 protein]]
Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ATP6 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ATP6 protein]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in decreased expression of ATP6 protein]]
CTD PMID:35202708 NCBI chr MT:7,919...8,599
NCBI chr MT:7,919...8,599
NCBI chr MT:7,919...8,599
Ensembl chr MT:7,919...8,599
JBrowse link
G Mt-cyb mitochondrially encoded cytochrome b multiple interactions ISO Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYTB protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYTB protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYTB protein]]
Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYTB protein]]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYTB protein]]
CTD PMID:35202708 NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
NCBI chr MT:14,136...15,278
Ensembl chr MT:14,136...15,278
JBrowse link
G Mt-nd1 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 multiple interactions ISO [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in decreased expression of ND1 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ND1 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ND1 protein]
Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ND1 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ND1 protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in decreased expression of ND1 protein]]
CTD PMID:35202708 NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
NCBI chr MT:2,740...3,694
Ensembl chr MT:2,740...3,694
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO sarpogrelate inhibits the reaction [Palmitic Acid results in increased activity of MTOR protein]; sarpogrelate inhibits the reaction [Serotonin results in increased activity of MTOR protein] CTD PMID:27133527 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP sarpogrelate promotes the reaction [Oxygen deficiency results in increased expression of NOS3 protein] CTD PMID:25931318 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 multiple interactions ISO sarpogrelate inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of PECAM1 protein] CTD PMID:27097221 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
JBrowse link
G Pln phospholamban affects expression EXP sarpogrelate affects the expression of PLN mRNA; sarpogrelate affects the expression of PLN protein CTD PMID:18088389 NCBI chr20:32,629,537...32,639,559 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP sarpogrelate inhibits the reaction [Serotonin results in increased expression of PTGS2 mRNA]; sarpogrelate inhibits the reaction [Serotonin results in increased expression of PTGS2 protein] CTD PMID:21262218 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein] CTD PMID:34560070 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Serpine2 serpin family E member 2 decreases expression
multiple interactions
ISO sarpogrelate results in decreased expression of SERPINE2 mRNA
sarpogrelate inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of SERPINE2 protein]; sarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased expression of SERPINE2 mRNA]; sarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein]
CTD PMID:24107419 PMID:27097221 NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826
JBrowse link
G Slc2a1 solute carrier family 2 member 1 affects expression EXP sarpogrelate affects the expression of SLC2A1 protein CTD PMID:21183729 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Slc2a4 solute carrier family 2 member 4 affects expression EXP sarpogrelate affects the expression of SLC2A4 protein CTD PMID:21183729 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Sorl1 sortilin related receptor 1 multiple interactions ISO sarpogrelate inhibits the reaction [Serotonin results in increased expression of SORL1 mRNA] CTD PMID:24650663 NCBI chr 8:42,341,704...42,504,435
Ensembl chr 8:42,341,704...42,504,513
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased phosphorylation of STAT3 protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased phosphorylation of STAT3 protein] CTD PMID:34560070 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO sarpogrelate inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TGFB1 protein]; sarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased expression of SERPINE2 mRNA]; sarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein] CTD PMID:24107419 PMID:27097221 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased secretion of TNF protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased secretion of TNF protein]
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased expression of TNF protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased expression of TNF protein]
CTD PMID:34560070 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tph1 tryptophan hydroxylase 1 multiple interactions ISO sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of TPH1 mRNA]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of TPH1 protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased expression of TPH1 protein]
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in increased expression of TPH1 mRNA]; [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in increased expression of TPH1 protein]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of TPH1 mRNA]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of TPH1 protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased expression of TPH1 protein]
CTD PMID:34560070 PMID:35202708 NCBI chr 1:97,157,375...97,178,415
Ensembl chr 1:97,157,409...97,178,344
JBrowse link
G Ugt1a5 UDP glucuronosyltransferase family 1 member A5 increases glucuronidation ISO UGT1A4 protein results in increased glucuronidation of sarpogrelate metabolite CTD PMID:23704698 NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of sarpogrelate metabolite CTD PMID:23704698 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO sarpogrelate inhibits the reaction [[Glucose co-treated with Serotonin] results in increased expression of VCAM1 protein] CTD PMID:22785018 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
succinic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [Oleanolic Acid analog binds to Succinic Acid] which results in increased expression of BAX mRNA; [Oleanolic Acid analog binds to Succinic Acid] which results in increased expression of BAX protein CTD PMID:31401087 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of BCL2L1 mRNA; [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of BCL2L1 protein CTD PMID:31401087 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Col2a1 collagen type II alpha 1 chain multiple interactions EXP [COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Succinic Acid; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Succinic Acid]; Dexamethasone inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Succinic Acid]; huang-lien-chieh-tu-tang inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Succinic Acid] CTD PMID:24709313 NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546
JBrowse link
G Dek DEK proto-oncogene multiple interactions ISO DEK protein affects the chemical synthesis of and affects the secretion of Succinic Acid CTD PMID:28558019 NCBI chr17:17,580,804...17,602,825
Ensembl chr17:17,580,843...17,602,808
JBrowse link
G Ercc6 ERCC excision repair 6, chromatin remodeling factor increases abundance ISO ERCC6 gene mutant form results in increased abundance of Succinic Acid CTD PMID:25440059 NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions EXP Succinic Acid inhibits the reaction [Rotenone affects the expression of HIF1A protein] CTD PMID:16034640 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Lepr leptin receptor affects abundance ISO LEPR affects the abundance of Succinic Acid CTD PMID:20567778 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of MYC mRNA; [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of MYC protein CTD PMID:31401087 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of NFKB1 mRNA CTD PMID:31401087 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 multiple interactions ISO [Glycerol co-treated with Succinic Acid co-treated with Glucose-6-Phosphate co-treated with Pantothenic Acid co-treated with Niacinamide] results in increased expression of NR4A1 mRNA CTD PMID:20505214 NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of PTGS2 mRNA; [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of PTGS2 protein CTD PMID:31401087 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of RELA mRNA CTD PMID:31401087 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Slc13a3 solute carrier family 13 member 3 affects binding ISO
EXP
Succinic Acid binds to SLC13A3 protein CTD PMID:12397032 NCBI chr 3:154,141,878...154,204,604
Ensembl chr 3:154,141,872...154,204,606
JBrowse link
G Slc22a25 solute carrier family 22, member 25 multiple interactions EXP Succinic Acid affects the reaction [SLC22A19 protein affects the transport of estrone sulfate]; Succinic Acid inhibits the reaction [SLC22A9 protein affects the transport of estrone sulfate] CTD PMID:16079298 PMID:18441515 NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions
increases activity
ISO [Succinic Acid results in increased activity of SLC22A6 protein] which results in increased uptake of p-Aminohippuric Acid CTD PMID:36958672 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions
increases activity
ISO [Succinic Acid results in increased activity of SLC22A8 protein] which results in increased uptake of p-Aminohippuric Acid CTD PMID:36958672 NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects abundance ISO SLCO1A4 protein affects the abundance of Succinic Acid CTD PMID:21561886 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of STAT3 mRNA CTD PMID:31401087 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
succinylcholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bche butyrylcholinesterase increases response to substance
increases metabolic processing
increases hydrolysis
affects hydrolysis
multiple interactions
decreases abundance
decreases hydrolysis
affects response to substance
ISO BCHE gene mutant form results in increased susceptibility to Succinylcholine; BCHE gene polymorphism results in increased susceptibility to Succinylcholine; BCHE protein mutant form results in increased susceptibility to Succinylcholine
BCHE protein results in increased metabolism of Succinylcholine
BCHE protein results in increased hydrolysis of Succinylcholine
BCHE protein mutant form affects the hydrolysis of Succinylcholine
[Dichlorvos results in decreased activity of BCHE protein] which results in increased susceptibility to Succinylcholine; Insecticides inhibits the reaction [BCHE protein results in increased metabolism of Succinylcholine]; Organophosphorus Compounds inhibits the reaction [BCHE protein results in increased metabolism of Succinylcholine]; Succinylcholine inhibits the reaction [BCHE protein results in increased hydrolysis of butyrylcholine]
BCHE protein results in decreased abundance of Succinylcholine
BCHE protein mutant form results in decreased hydrolysis of Succinylcholine
BCHE affects the susceptibility to Succinylcholine; BCHE gene mutant form affects the susceptibility to Succinylcholine; BCHE gene polymorphism affects the susceptibility to Succinylcholine; BCHE protein affects the susceptibility to Succinylcholine
CTD PMID:726855 PMID:900467 PMID:987736 PMID:1058931 PMID:1147298 More... NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions ISO Succinylcholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:14645658 NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions ISO Succinylcholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]] CTD PMID:14645658 NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
JBrowse link
G Mb myoglobin increases secretion ISO Succinylcholine results in increased secretion of MB protein CTD PMID:8217179 NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383
JBrowse link
suxibuzone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pklr pyruvate kinase L/R decreases activity EXP suxibuzone results in decreased activity of PKLR protein CTD PMID:3107799 NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870
JBrowse link
teprenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO geranylgeranylacetone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of and results in increased cleavage of CASP3 protein] CTD PMID:34732784 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO geranylgeranylacetone inhibits the reaction [Bleomycin results in decreased expression of CDH1 mRNA]; geranylgeranylacetone inhibits the reaction [Bleomycin results in decreased expression of CDH1 protein]
geranylgeranylacetone inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 mRNA]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]
CTD PMID:37307957 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]; geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of COL1A1 protein] CTD PMID:37307957 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Col1a2 collagen type I alpha 2 chain multiple interactions ISO geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of COL1A2 mRNA]; geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of COL1A2 protein] CTD PMID:37307957 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
JBrowse link
G Dlg1 discs large MAGUK scaffold protein 1 increases expression
multiple interactions
ISO geranylgeranylacetone results in increased expression of DLG1 mRNA; geranylgeranylacetone results in increased expression of DLG1 protein
geranylgeranylacetone promotes the reaction [[HSF1 protein binds to DLG1 promoter] which results in increased expression of DLG1 mRNA]; Niacinamide inhibits the reaction [geranylgeranylacetone results in increased expression of DLG1 mRNA]; resveratrol promotes the reaction [geranylgeranylacetone results in increased expression of DLG1 mRNA]
CTD PMID:21232033 NCBI chr11:68,911,883...69,103,230
Ensembl chr11:68,911,883...69,102,689
JBrowse link
G Edn1 endothelin 1 decreases expression EXP geranylgeranylacetone results in decreased expression of EDN1 protein CTD PMID:16324314 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of FN1 mRNA]; geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of FN1 protein] CTD PMID:37307957 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Hsf1 heat shock transcription factor 1 multiple interactions
affects response to substance
increases expression
ISO geranylgeranylacetone promotes the reaction [[HSF1 protein binds to DLG1 promoter] which results in increased expression of DLG1 mRNA]
HSF1 protein affects the susceptibility to geranylgeranylacetone
geranylgeranylacetone results in increased expression of HSF1 protein
CTD PMID:17189318 PMID:21232033 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A multiple interactions ISO geranylgeranylacetone promotes the reaction [Bleomycin results in increased expression of HSPA1A mRNA]; geranylgeranylacetone promotes the reaction [Ethanol results in increased expression of HSPA1A protein]
geranylgeranylacetone promotes the reaction [TGFB1 protein results in increased expression of HSPA1A mRNA]; geranylgeranylacetone promotes the reaction [TGFB1 protein results in increased expression of HSPA1A protein]
CTD PMID:17189318 PMID:37307957 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B multiple interactions ISO [Tetrachlorodibenzodioxin co-treated with geranylgeranylacetone] results in increased expression of HSPA1B mRNA; [Tetrachlorodibenzodioxin co-treated with geranylgeranylacetone] results in increased expression of HSPA1B protein; geranylgeranylacetone promotes the reaction [Bleomycin results in increased expression of HSPA1B mRNA]
geranylgeranylacetone promotes the reaction [TGFB1 protein results in increased expression of HSPA1B mRNA]; geranylgeranylacetone promotes the reaction [TGFB1 protein results in increased expression of HSPA1B protein]
CTD PMID:15340226 PMID:37307957 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240
JBrowse link
G Kcna5 potassium voltage-gated channel subfamily A member 5 increases expression ISO geranylgeranylacetone results in increased expression of KCNA5 protein CTD PMID:21232033 NCBI chr 4:159,354,689...159,358,173
Ensembl chr 4:159,350,097...159,357,697
JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 multiple interactions ISO geranylgeranylacetone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of MAP3K5 protein] CTD PMID:34732784 NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of NOX4 mRNA]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of NOX4 protein]
geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of NOX4 mRNA]
CTD PMID:37307957 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO geranylgeranylacetone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased cleavage of PARP1 protein] CTD PMID:34732784 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO geranylgeranylacetone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of RELA protein]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of RELA mRNA]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of RELA protein]
geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of RELA mRNA]
CTD PMID:34732784 PMID:37307957 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO geranylgeranylacetone inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 mRNA]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of NOX4 mRNA]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of NOX4 protein]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of RELA mRNA]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of RELA protein]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of VIM mRNA]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]; geranylgeranylacetone promotes the reaction [TGFB1 protein results in increased expression of HSPA1A mRNA]; geranylgeranylacetone promotes the reaction [TGFB1 protein results in increased expression of HSPA1A protein]; geranylgeranylacetone promotes the reaction [TGFB1 protein results in increased expression of HSPA1B mRNA]; geranylgeranylacetone promotes the reaction [TGFB1 protein results in increased expression of HSPA1B protein] CTD PMID:37307957 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Txn1 thioredoxin 1 multiple interactions ISO geranylgeranylacetone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TXN mRNA]; geranylgeranylacetone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TXN protein] CTD PMID:34732784 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
JBrowse link
G Vim vimentin multiple interactions ISO geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of VIM mRNA]; geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of VIM protein]
geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of VIM mRNA]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]
CTD PMID:37307957 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
thiomalic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Endog endonuclease G multiple interactions EXP [Hydrogen Peroxide co-treated with 2-thiomalic acid] affects the localization of ENDOG protein CTD PMID:16407272 NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932
JBrowse link
G Gpx1 glutathione peroxidase 1 decreases activity ISO 2-thiomalic acid results in decreased activity of GPX1 protein CTD PMID:21892612 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 2-thiomalic acid promotes the reaction [Asbestos, Crocidolite results in increased secretion of TNF protein] CTD PMID:10486238 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
tiquizium bromide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO thiaton results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP thiaton inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:11855677 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP thiaton inhibits the reaction [Indomethacin results in increased activity of NOS2 protein] CTD PMID:11855677 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19918
    role 19894
      application 19729
        pharmaceutical 19565
          drug 19565
            anti-ulcer drug 1189
              (11R,16S)-misoprostol + 15
              16,16-dimethylprostaglandin E2 8
              Yosprala 0
              alpha-methylene gamma-butyrolactone + 0
              amlexanox 37
              anisotropine methylbromide 0
              balsalazide + 1
              balsalazide disodium 0
              cetraxate 0
              cimetidine + 69
              cimetidine hydrochloride 0
              cisapride 12
              egualen 0
              egualen sodium 0
              esomeprazole + 407
              esomeprazole magnesium 0
              eupatilin 10
              famotidine + 61
              homatropine methylbromide 0
              lansoprazole 64
              misoprostol 15
              nizatidine 2
              omeprazole + 407
              oxmetidine 0
              pantoprazole 27
              pantoprazole sodium 0
              pibutidine 0
              pibutidine hydrochloride 0
              pifarnine 0
              pirenzepine + 8
              plaunotol 3
              proglumide + 0
              rabeprazole 18
              ranitidine + 136
              rohitukine 0
              sofalcone 0
              succinic acid + 656
              teprenone 18
              tiquizium + 3
              tiquizium bromide 3
              tridihexethyl + 0
              vedaprofen 0
paths to the root