CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: anti-ulcer drug
Accession: CHEBI:49201
browse the term
Definition: One of various classes of drugs with different action mechanisms used to treat or ameliorate peptic ulcer or irritation of the gastrointestinal tract.
Synonyms: related_synonym: anti-ulcer agent; anti-ulcer agents; anti-ulcer drugs
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Akt1
AKT serine/threonine kinase 1
increases phosphorylation multiple interactions
ISO
16,16-Dimethylprostaglandin E2 results in increased phosphorylation of AKT1 protein EGFR affects the reaction [16,16-Dimethylprostaglandin E2 results in increased phosphorylation of AKT1 protein]
CTD
PMID:15578100
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Bax
BCL2 associated X, apoptosis regulator
increases response to substance affects localization
ISO
BAX results in increased susceptibility to 16,16-Dimethylprostaglandin E2 16,16-Dimethylprostaglandin E2 affects the localization of BAX protein
CTD
PMID:15578100
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Egfr
epidermal growth factor receptor
multiple interactions
ISO
EGFR affects the reaction [16,16-Dimethylprostaglandin E2 results in increased phosphorylation of AKT1 protein]
CTD
PMID:15578100
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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Hpgd
15-hydroxyprostaglandin dehydrogenase
increases activity
ISO
16,16-Dimethylprostaglandin E2 results in increased activity of HPGD protein
CTD
PMID:14736730
NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228
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Mpo
myeloperoxidase
multiple interactions
EXP
16,16-Dimethylprostaglandin E2 inhibits the reaction [Indomethacin results in increased activity of MPO protein]
CTD
PMID:11686837 PMID:11855677 PMID:11991626 PMID:18306037
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Nos2
nitric oxide synthase 2
multiple interactions
EXP
16,16-Dimethylprostaglandin E2 inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]; 16,16-Dimethylprostaglandin E2 inhibits the reaction [Indomethacin results in increased expression of NOS2 mRNA]
CTD
PMID:11686837 PMID:11855677 PMID:11991626 PMID:15610444 PMID:18306037
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions increases expression
ISO EXP
Flurbiprofen inhibits the reaction [16,16-Dimethylprostaglandin E2 results in increased expression of PTGS2 mRNA] 16,16-Dimethylprostaglandin E2 inhibits the reaction [SC 560 results in increased expression of PTGS2 mRNA]
CTD
PMID:9099957 PMID:15610444
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Tnf
tumor necrosis factor
multiple interactions
ISO
16,16-Dimethylprostaglandin E2 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF]
CTD
PMID:9298541
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression
EXP
5-hydroxymethylomeprazole results in increased expression of CYP1A1 protein
CTD
PMID:10103034
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Acaca
acetyl-CoA carboxylase alpha
multiple interactions
ISO
amlexanox inhibits the reaction [Palmitic Acid results in increased expression of ACACA mRNA]
CTD
PMID:32905826
NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
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Adgre1
adhesion G protein-coupled receptor E1
multiple interactions decreases expression
ISO
amlexanox inhibits the reaction [Palmitic Acid results in increased expression of ADGRE1 mRNA] amlexanox results in decreased expression of ADGRE1 mRNA
CTD
PMID:32905826
NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000
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Arg1
arginase 1
multiple interactions
ISO
amlexanox affects the reaction [Palmitic Acid affects the expression of ARG1 mRNA]; amlexanox inhibits the reaction [Palmitic Acid results in decreased expression of ARG1 protein]
CTD
PMID:32905826
NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions decreases expression
ISO
amlexanox inhibits the reaction [Acetaminophen results in increased expression of BAX protein]; amlexanox inhibits the reaction [Palmitic Acid results in increased expression of BAX protein] amlexanox results in decreased expression of BAX protein
CTD
PMID:31697998 PMID:32905826
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
multiple interactions
ISO
amlexanox inhibits the reaction [Acetaminophen results in decreased expression of BCL2 protein]; amlexanox inhibits the reaction [Palmitic Acid results in decreased expression of BCL2 protein]
CTD
PMID:31697998 PMID:32905826
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Casp3
caspase 3
multiple interactions
ISO
amlexanox inhibits the reaction [Palmitic Acid results in increased cleavage of CASP3 protein]
CTD
PMID:32905826
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Ccl2
C-C motif chemokine ligand 2
multiple interactions
ISO
amlexanox inhibits the reaction [Acetaminophen results in increased expression of CCL2 mRNA]
CTD
PMID:31697998
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Cd14
CD14 molecule
multiple interactions
ISO
amlexanox inhibits the reaction [Palmitic Acid results in increased expression of CD14 mRNA]
CTD
PMID:32905826
NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
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Cd68
Cd68 molecule
multiple interactions
ISO
amlexanox inhibits the reaction [Palmitic Acid results in increased expression of CD68 mRNA]
CTD
PMID:32905826
NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697
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Cpt1a
carnitine palmitoyltransferase 1A
multiple interactions
ISO
amlexanox inhibits the reaction [Palmitic Acid results in decreased expression of CPT1A mRNA]
CTD
PMID:32905826
NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
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Cxcl2
C-X-C motif chemokine ligand 2
multiple interactions
ISO
amlexanox inhibits the reaction [Acetaminophen results in increased expression of CXCL2 mRNA]
CTD
PMID:31697998
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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Cxcl3
C-X-C motif chemokine ligand 3
multiple interactions
ISO
amlexanox inhibits the reaction [Acetaminophen results in increased expression of CXCL1 mRNA]
CTD
PMID:31697998
NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
multiple interactions
ISO
amlexanox inhibits the reaction [Palmitic Acid results in increased expression of CYP2E1 mRNA]; amlexanox inhibits the reaction [Palmitic Acid results in increased expression of CYP2E1 protein]
CTD
PMID:32905826
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Dgat1
diacylglycerol O-acyltransferase 1
multiple interactions
ISO
amlexanox inhibits the reaction [Palmitic Acid results in increased expression of DGAT1 mRNA]
CTD
PMID:32905826
NCBI chr 7:108,223,860...108,235,413
Ensembl chr 7:108,218,524...108,234,299
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Fasn
fatty acid synthase
multiple interactions
ISO
amlexanox inhibits the reaction [Palmitic Acid results in increased expression of FASN mRNA]
CTD
PMID:32905826
NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
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Fgf1
fibroblast growth factor 1
multiple interactions
ISO
[amlexanox binds to FGF1 protein] inhibits the reaction [cupric chloride results in increased oxidation of FGF1 protein]; amlexanox binds to and results in increased stability of and results in decreased secretion of FGF1 protein; amlexanox inhibits the reaction [FGF1 protein binds to FGF1 protein]
CTD
PMID:16300395
NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
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Gclc
glutamate-cysteine ligase, catalytic subunit
multiple interactions increases expression
ISO
[Acetaminophen co-treated with amlexanox co-treated with dorsomorphin] affects the expression of GCLC mRNA; [Acetaminophen co-treated with amlexanox] affects the expression of GCLC mRNA amlexanox results in increased expression of GCLC mRNA
CTD
PMID:31697998
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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Gclm
glutamate cysteine ligase, modifier subunit
multiple interactions
ISO
[Acetaminophen co-treated with amlexanox co-treated with dorsomorphin] affects the expression of GCLM mRNA
CTD
PMID:31697998
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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Gpt
glutamic--pyruvic transaminase
multiple interactions
ISO
amlexanox inhibits the reaction [Acetaminophen results in increased expression of GPT protein]; dorsomorphin inhibits the reaction [amlexanox inhibits the reaction [Acetaminophen results in increased expression of GPT protein]]
CTD
PMID:31697998
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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Gpx1
glutathione peroxidase 1
affects localization
ISO
amlexanox affects the localization of GPX1 mRNA mutant form
CTD
PMID:28743738
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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Hmox1
heme oxygenase 1
multiple interactions increases expression
ISO
[amlexanox co-treated with Acetaminophen] results in increased expression of HMOX1 mRNA; [amlexanox co-treated with Palmitic Acid] results in increased expression of HMOX1 mRNA; amlexanox promotes the reaction [Acetaminophen results in increased expression of HMOX1 protein]; dorsomorphin inhibits the reaction [[amlexanox co-treated with Acetaminophen] results in increased expression of HMOX1 mRNA] amlexanox results in increased expression of HMOX1 mRNA
CTD
PMID:31697998 PMID:32905826
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Ifnb1
interferon beta 1
multiple interactions
ISO
amlexanox inhibits the reaction [Palmitic Acid results in increased expression of IFNB1 mRNA]; amlexanox inhibits the reaction [Paraquat results in increased secretion of IFNB1 protein]
CTD
PMID:32763286 PMID:32905826
NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523
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Ikbke
inhibitor of nuclear factor kappa B kinase subunit epsilon
decreases activity multiple interactions
ISO
amlexanox results in decreased activity of IKBKE protein amlexanox inhibits the reaction [Acetaminophen results in increased phosphorylation of IKBKE protein]; amlexanox inhibits the reaction [Palmitic Acid results in increased phosphorylation of IKBKE protein]
CTD
PMID:25321315 PMID:31697998 PMID:32905826
NCBI chr13:42,712,154...42,738,470
Ensembl chr13:42,712,159...42,737,143
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Il10
interleukin 10
multiple interactions
ISO
amlexanox affects the reaction [Palmitic Acid affects the expression of IL10 mRNA]; amlexanox inhibits the reaction [Palmitic Acid results in decreased expression of IL10 protein]
CTD
PMID:32905826
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il1b
interleukin 1 beta
multiple interactions
ISO
amlexanox inhibits the reaction [Acetaminophen results in increased expression of IL1B mRNA]; amlexanox inhibits the reaction [Palmitic Acid results in increased expression of IL1B mRNA]; amlexanox inhibits the reaction [Palmitic Acid results in increased secretion of IL1B protein]; amlexanox inhibits the reaction [Paraquat results in increased secretion of IL1B protein]
CTD
PMID:31697998 PMID:32763286 PMID:32905826
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il6
interleukin 6
multiple interactions
ISO
amlexanox inhibits the reaction [Acetaminophen results in increased expression of IL6 mRNA]; amlexanox inhibits the reaction [Palmitic Acid results in increased expression of IL6 mRNA]; amlexanox inhibits the reaction [Palmitic Acid results in increased secretion of IL6 protein]
CTD
PMID:31697998 PMID:32905826
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Irf3
interferon regulatory factor 3
multiple interactions
ISO
amlexanox inhibits the reaction [Palmitic Acid results in increased phosphorylation of IRF3 protein]; amlexanox inhibits the reaction [Paraquat affects the localization of IRF3 protein]
CTD
PMID:32763286 PMID:32905826
NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935
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Nfe2l2
NFE2 like bZIP transcription factor 2
increases expression multiple interactions
ISO
amlexanox results in increased expression of NFE2L2 protein [Acetaminophen co-treated with amlexanox] results in increased expression of NFE2L2 protein; amlexanox inhibits the reaction [Acetaminophen results in decreased expression of NFE2L2 protein]; dorsomorphin inhibits the reaction [amlexanox inhibits the reaction [Acetaminophen results in decreased expression of NFE2L2 protein]]
CTD
PMID:31697998
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nos2
nitric oxide synthase 2
multiple interactions
ISO
amlexanox inhibits the reaction [Palmitic Acid results in increased expression of NOS2 mRNA]; amlexanox inhibits the reaction [Palmitic Acid results in increased expression of NOS2 protein]; mifobate inhibits the reaction [amlexanox inhibits the reaction [Palmitic Acid results in increased expression of NOS2 mRNA]]
CTD
PMID:32905826
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Nqo1
NAD(P)H quinone dehydrogenase 1
multiple interactions
ISO
dorsomorphin inhibits the reaction [[Acetaminophen co-treated with amlexanox] affects the expression of NQO1 mRNA]
CTD
PMID:31697998
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Ppara
peroxisome proliferator activated receptor alpha
multiple interactions
ISO
amlexanox inhibits the reaction [Palmitic Acid results in decreased expression of PPARA mRNA]; amlexanox inhibits the reaction [Palmitic Acid results in decreased expression of PPARA protein]; amlexanox promotes the reaction [Palmitic Acid results in increased expression of PPARA protein]
CTD
PMID:32905826
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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Prkaa1
protein kinase AMP-activated catalytic subunit alpha 1
increases phosphorylation multiple interactions
ISO
amlexanox results in increased phosphorylation of PRKAA1 protein [Acetaminophen co-treated with amlexanox] results in increased phosphorylation of PRKAA1 protein; amlexanox inhibits the reaction [Acetaminophen results in decreased phosphorylation of PRKAA1 protein]; dorsomorphin inhibits the reaction [amlexanox inhibits the reaction [Acetaminophen results in decreased phosphorylation of PRKAA1 protein]]
CTD
PMID:31697998
NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
amlexanox inhibits the reaction [Acetaminophen results in increased phosphorylation of RELA protein]; amlexanox inhibits the reaction [Paraquat affects the localization of RELA protein]
CTD
PMID:31697998 PMID:32763286
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Srebf1
sterol regulatory element binding transcription factor 1
decreases expression multiple interactions
ISO
amlexanox results in decreased expression of SREBF1 mRNA amlexanox inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 mRNA]
CTD
PMID:32905826
NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
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Tbk1
TANK-binding kinase 1
decreases activity decreases phosphorylation multiple interactions
ISO
amlexanox results in decreased activity of TBK1 protein amlexanox results in decreased phosphorylation of TBK1 protein amlexanox inhibits the reaction [Acetaminophen results in increased phosphorylation of TBK1 protein]; amlexanox inhibits the reaction [Palmitic Acid results in increased phosphorylation of TBK1 protein]; amlexanox inhibits the reaction [Paraquat results in increased phosphorylation of TBK1 protein]
CTD
PMID:25321315 PMID:31697998 PMID:32763286 PMID:32905826
NCBI chr 7:57,077,830...57,110,868
Ensembl chr 7:57,077,830...57,110,892
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Tnf
tumor necrosis factor
multiple interactions
ISO
amlexanox inhibits the reaction [Acetaminophen results in increased expression of TNF mRNA]; amlexanox inhibits the reaction [Palmitic Acid results in increased expression of TNF mRNA]; amlexanox inhibits the reaction [Palmitic Acid results in increased secretion of TNF protein]
CTD
PMID:31697998 PMID:32905826
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Upf1
UPF1, RNA helicase and ATPase
affects localization
ISO
amlexanox affects the localization of UPF1 protein
CTD
PMID:28743738
NCBI chr16:19,076,594...19,097,365
Ensembl chr16:19,076,322...19,096,568
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Acta2
actin alpha 2, smooth muscle
multiple interactions decreases expression
ISO
Deferoxamine inhibits the reaction [Artesunate results in decreased expression of ACTA2 mRNA] Artesunate results in decreased expression of ACTA2 mRNA; Artesunate results in decreased expression of ACTA2 protein Artesunate inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]
CTD
PMID:30551460
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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Aifm1
apoptosis inducing factor, mitochondria associated 1
affects localization
ISO
artesunate affects the localization of AIFM1 protein
CTD
PMID:24704559
NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
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Ar
androgen receptor
multiple interactions
ISO
artesunate binds to and results in decreased activity of AR protein
CTD
PMID:25752796
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Atg12
autophagy related 12
increases expression
ISO
Artesunate results in increased expression of ATG12 mRNA
CTD
PMID:30551460
NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418
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Atg3
autophagy related 3
increases expression
ISO
Artesunate results in increased expression of ATG3 mRNA
CTD
PMID:30551460
NCBI chr11:55,624,914...55,653,249
Ensembl chr11:55,624,917...55,653,224
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Atg5
autophagy related 5
increases expression
ISO
Artesunate results in increased expression of ATG5 mRNA
CTD
PMID:30551460
NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209
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Bax
BCL2 associated X, apoptosis regulator
increases expression multiple interactions
ISO EXP
Artesunate results in increased expression of BAX protein [1,2-Dimethylhydrazine co-treated with artesunate] results in increased expression of BAX protein
CTD
PMID:24704559 PMID:29031619 PMID:33002460
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
decreases expression multiple interactions
ISO EXP
Artesunate results in decreased expression of BCL2 protein 3-methyladenine inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; acadesine promotes the reaction [Artesunate results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; dorsomorphin inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; Sirolimus promotes the reaction [Artesunate results in decreased expression of BCL2 protein] [1,2-Dimethylhydrazine co-treated with artesunate] results in decreased expression of BCL2 protein
CTD
PMID:24704559 PMID:29031619 PMID:33002460
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bst1
bone marrow stromal cell antigen 1
increases response to substance
ISO
BST1 mRNA results in increased susceptibility to artesunate
CTD
PMID:20144594
NCBI chr14:67,253,706...67,270,203
Ensembl chr14:67,252,998...67,270,180
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Casp3
caspase 3
increases activity increases cleavage multiple interactions
ISO
artesunate results in increased activity of CASP3 protein Artesunate results in increased cleavage of CASP3 protein 3-methyladenine inhibits the reaction [Artesunate results in increased cleavage of CASP3 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [Artesunate results in increased cleavage of CASP3 protein]; Sirolimus promotes the reaction [Artesunate results in increased cleavage of CASP3 protein]
CTD
PMID:19513562 PMID:24704559 PMID:33002460
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp9
caspase 9
affects expression
ISO
artesunate affects the expression of CASP9 protein
CTD
PMID:24704559
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cat
catalase
increases expression decreases response to substance
ISO
artesunate results in increased expression of CAT protein CAT protein results in decreased susceptibility to artesunate
CTD
PMID:19513562 PMID:20144594
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Cct2
chaperonin containing TCP1 subunit 2
decreases response to substance
ISO
CCT2 mRNA results in decreased susceptibility to artesunate
CTD
PMID:20144594
NCBI chr 7:52,692,725...52,705,478
Ensembl chr 7:52,692,725...52,706,944
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Chek1
checkpoint kinase 1
multiple interactions increases phosphorylation
ISO
APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of CHEK1 protein]
CTD
PMID:31664825
NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
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Chek2
checkpoint kinase 2
multiple interactions increases phosphorylation
ISO
APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of CHEK2 protein]
CTD
PMID:31664825
NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
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Clip4
CAP-GLY domain containing linker protein family, member 4
increases response to substance
ISO
CLIP4 mRNA results in increased susceptibility to artesunate
CTD
PMID:20144594
NCBI chr 6:23,616,280...23,697,625
Ensembl chr 6:23,616,281...23,677,874
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Coq8a
coenzyme Q8A
decreases response to substance
ISO
COQ8A mRNA results in decreased susceptibility to artesunate
CTD
PMID:20144594
NCBI chr13:91,904,731...91,933,588
Ensembl chr13:91,904,739...91,931,431
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Ctnnb1
catenin beta 1
multiple interactions
EXP
artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of CTNNB1 protein]
CTD
PMID:29031619
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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Dbh
dopamine beta-hydroxylase
increases response to substance
ISO
DBH mRNA results in increased susceptibility to artesunate
CTD
PMID:20144594
NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248
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Des
desmin
multiple interactions decreases expression
ISO
Deferoxamine inhibits the reaction [Artesunate results in decreased expression of DES mRNA] Artesunate results in decreased expression of DES mRNA; Artesunate results in decreased expression of DES protein
CTD
PMID:30551460
NCBI chr 9:76,850,979...76,858,695
Ensembl chr 9:76,850,982...76,858,699
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Esr1
estrogen receptor 1
multiple interactions
ISO
artesunate binds to and results in decreased activity of ESR1 protein
CTD
PMID:25752796
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
G
Fas
Fas cell surface death receptor
increases expression
ISO
artesunate results in increased expression of FAS protein
CTD
PMID:19513562
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Flna
filamin A
increases response to substance
ISO
FLNA mRNA results in increased susceptibility to artesunate
CTD
PMID:20144594
NCBI chr X:152,007,758...152,034,266
Ensembl chr X:152,007,758...152,031,052
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Fn1
fibronectin 1
multiple interactions decreases expression
ISO
Deferoxamine inhibits the reaction [Artesunate results in decreased expression of FN1 mRNA] Artesunate results in decreased expression of FN1 mRNA; Artesunate results in decreased expression of FN1 protein
CTD
PMID:30551460
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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Fth1
ferritin heavy chain 1
decreases expression multiple interactions
ISO
Artesunate results in decreased expression of FTH1 mRNA; Artesunate results in decreased expression of FTH1 protein Chloroquine inhibits the reaction [Artesunate results in decreased expression of FTH1 mRNA]
CTD
PMID:30551460
NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
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Fzd7
frizzled class receptor 7
increases response to substance
ISO
FZD7 mRNA results in increased susceptibility to artesunate
CTD
PMID:20144594
NCBI chr 9:60,931,433...60,934,252
Ensembl chr 9:60,930,875...60,935,781
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Gclc
glutamate-cysteine ligase, catalytic subunit
affects response to substance decreases response to substance
ISO
GCLC mRNA affects the susceptibility to artesunate GCLC mRNA results in decreased susceptibility to artesunate
CTD
PMID:15796179
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
G
Gclm
glutamate cysteine ligase, modifier subunit
decreases response to substance
ISO
GCLM mRNA results in decreased susceptibility to artesunate
CTD
PMID:15796179
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
G
Gpx4
glutathione peroxidase 4
decreases activity multiple interactions
ISO
Artesunate results in decreased activity of GPX4 protein Artesunate inhibits the reaction [Carbon Tetrachloride results in increased expression of GPX4 protein]
CTD
PMID:30551460
NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
G
Gstm4
glutathione S-transferase mu 4
affects response to substance
ISO
GSTM4 mRNA affects the susceptibility to artesunate
CTD
PMID:15796179
NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323
G
Gstp1
glutathione S-transferase pi 1
decreases expression
ISO
artesunate results in decreased expression of GSTP1 protein
CTD
PMID:19513562
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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Gstt2
glutathione S-transferase theta 2
affects response to substance
ISO
GSTT2 mRNA affects the susceptibility to artesunate
CTD
PMID:15796179
NCBI chr20:12,819,617...12,823,288
Ensembl chr20:12,819,170...12,823,288
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Gstz1
glutathione S-transferase zeta 1
affects response to substance
ISO
GSTZ1 mRNA affects the susceptibility to artesunate
CTD
PMID:15796179
NCBI chr 6:106,794,594...106,805,284
Ensembl chr 6:106,794,074...106,805,284
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H2ax
H2A.X variant histone
multiple interactions increases phosphorylation
ISO
APOBEC3C protein promotes the reaction [Artesunate results in increased phosphorylation of H2AX protein]
CTD
PMID:31664825
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
G
Il1b
interleukin 1 beta
multiple interactions
EXP
Artesunate inhibits the reaction [Ethanol results in increased expression of IL1B protein]; Artesunate inhibits the reaction [Glucose results in increased expression of IL1B mRNA]; Artesunate inhibits the reaction [Glucose results in increased secretion of IL1B protein]
CTD
PMID:27474069 PMID:30031708
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il6
interleukin 6
multiple interactions
EXP
Artesunate inhibits the reaction [Ethanol results in increased expression of IL6 protein]; Artesunate inhibits the reaction [Glucose results in increased expression of IL6 mRNA]; Artesunate inhibits the reaction [Glucose results in increased secretion of IL6 protein]
CTD
PMID:27474069 PMID:30031708
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Itgb1
integrin subunit beta 1
increases response to substance
ISO
ITGB1 mRNA results in increased susceptibility to artesunate
CTD
PMID:20144594
NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
G
Map1lc3b
microtubule-associated protein 1 light chain 3 beta
multiple interactions increases lipidation
ISO
3-methyladenine inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; acadesine promotes the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; Acetylcysteine inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; dorsomorphin inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; Sirolimus promotes the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]
CTD
PMID:33002460
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
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Mgst3
microsomal glutathione S-transferase 3
affects response to substance
ISO
MGST3 mRNA affects the susceptibility to artesunate
CTD
PMID:15796179
NCBI chr13:79,526,541...79,547,479
Ensembl chr13:79,526,541...79,547,411
G
Mki67
marker of proliferation Ki-67
multiple interactions
EXP
artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MKI67 protein]
CTD
PMID:29031619
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
G
Mmp9
matrix metallopeptidase 9
multiple interactions decreases expression
EXP ISO
artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of MMP9 protein] Chloroquine inhibits the reaction [Artesunate results in decreased expression of MMP9 mRNA]
CTD
PMID:29031619 PMID:30551460
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
G
Mpo
myeloperoxidase
multiple interactions
EXP
artesunate inhibits the reaction [Ethanol results in increased activity of MPO protein]
CTD
PMID:27474069
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
G
Mthfd2
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
decreases response to substance
ISO
MTHFD2 mRNA results in decreased susceptibility to artesunate
CTD
PMID:20144594
NCBI chr 4:115,811,135...115,822,663
Ensembl chr 4:115,811,139...115,822,608
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Mtor
mechanistic target of rapamycin kinase
multiple interactions decreases phosphorylation
ISO
acadesine promotes the reaction [Artesunate results in decreased phosphorylation of MTOR protein]; Acetylcysteine inhibits the reaction [Artesunate results in decreased phosphorylation of MTOR protein]; dorsomorphin inhibits the reaction [Artesunate results in decreased phosphorylation of MTOR protein]
CTD
PMID:33002460
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
G
Myd88
MYD88, innate immune signal transduction adaptor
multiple interactions
EXP
artesunate inhibits the reaction [Glucose results in increased expression of MYD88 protein]
CTD
PMID:30031708
NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
G
Naca
nascent polypeptide associated complex subunit alpha
decreases response to substance
ISO
NACA mRNA results in decreased susceptibility to artesunate
CTD
PMID:20144594
NCBI chr 7:468,862...481,992
Ensembl chr 7:469,723...481,992
G
Nckap1
NCK-associated protein 1
increases response to substance
ISO
NCKAP1 mRNA results in increased susceptibility to artesunate
CTD
PMID:20144594
NCBI chr 3:65,417,450...65,491,769
Ensembl chr 3:65,417,453...65,492,217
G
Ncoa4
nuclear receptor coactivator 4
multiple interactions decreases expression
ISO
Chloroquine inhibits the reaction [Artesunate results in decreased expression of NCOA4 mRNA] Artesunate results in decreased expression of NCOA4 mRNA; Artesunate results in decreased expression of NCOA4 protein
CTD
PMID:30551460
NCBI chr16:7,389,222...7,409,564
Ensembl chr16:7,366,542...7,409,641 Ensembl chr16:7,366,542...7,409,641
G
Nfe2l2
NFE2 like bZIP transcription factor 2
affects localization
ISO
artesunate affects the localization of NFE2L2 protein
CTD
PMID:26340163
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
G
Nlrp3
NLR family, pyrin domain containing 3
multiple interactions
EXP
artesunate inhibits the reaction [Glucose results in increased expression of NLRP3 protein]
CTD
PMID:30031708
NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
G
Parp1
poly (ADP-ribose) polymerase 1
increases cleavage multiple interactions
ISO
Artesunate results in increased cleavage of PARP1 protein 3-methyladenine inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; acadesine promotes the reaction [Artesunate results in increased cleavage of PARP1 protein]; Acetylcysteine inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; dorsomorphin inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; Sirolimus promotes the reaction [Artesunate results in increased cleavage of PARP1 protein]
CTD
PMID:24704559 PMID:33002460
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
G
Pcna
proliferating cell nuclear antigen
multiple interactions
EXP
artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of PCNA protein]
CTD
PMID:29031619
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
G
Pgr
progesterone receptor
multiple interactions
ISO
artesunate binds to and results in increased activity of PGR protein
CTD
PMID:25752796
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
[Carbon Tetrachloride results in increased susceptibility to Artesunate] which results in increased expression of PTGS2 mRNA; [Carbon Tetrachloride results in increased susceptibility to Artesunate] which results in increased expression of PTGS2 protein
CTD
PMID:30551460
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
EXP
artesunate inhibits the reaction [Ethanol results in increased expression of RELA protein]; artesunate inhibits the reaction [Glucose results in increased phosphorylation of RELA protein]
CTD
PMID:27474069 PMID:30031708
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
G
Rpa2
replication protein A2
increases phosphorylation
ISO
Artesunate results in increased phosphorylation of RPA2 protein
CTD
PMID:31664825
NCBI chr 5:144,976,789...144,989,445
Ensembl chr 5:144,976,748...144,987,350
G
Rpl41
ribosomal protein L41
decreases response to substance
ISO
RPL41 mRNA results in decreased susceptibility to artesunate
CTD
PMID:20144594
NCBI chr 7:977,885...978,965
G
Rpl6
ribosomal protein L6
decreases response to substance
ISO
RPL6 mRNA results in decreased susceptibility to artesunate
CTD
PMID:20144594
NCBI chr12:35,347,493...35,352,011
Ensembl chr12:35,347,497...35,351,921
G
Rpl7
ribosomal protein L7
decreases response to substance
ISO
RPL7 mRNA results in decreased susceptibility to artesunate
CTD
PMID:20144594
NCBI chr 5:3,217,184...3,220,192
G
Rps12
ribosomal protein S12
decreases response to substance
ISO
RPS12 mRNA results in decreased susceptibility to artesunate
CTD
PMID:20144594
NCBI chr 1:21,680,854...21,683,010
Ensembl chr 1:21,680,852...21,683,014
G
Rps15a
ribosomal protein S15a
decreases response to substance
ISO
RPS15A mRNA results in decreased susceptibility to artesunate
CTD
PMID:20144594
NCBI chr 1:172,420,151...172,427,021
Ensembl chr 1:172,419,761...172,426,995
G
Rps6
ribosomal protein S6
decreases response to substance
ISO
RPS6 mRNA results in decreased susceptibility to artesunate
CTD
PMID:20144594
NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602 Ensembl chr 5:101,371,136...101,374,602
G
Slc25a19
solute carrier family 25 member 19
decreases response to substance
ISO
SLC25A19 mRNA results in decreased susceptibility to artesunate
CTD
PMID:20144594
NCBI chr10:100,853,554...100,867,517
Ensembl chr10:100,847,168...100,867,447
G
Sp1
Sp1 transcription factor
decreases expression
ISO
artesunate results in decreased expression of SP1 protein
CTD
PMID:19513562
NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
G
Sqstm1
sequestosome 1
multiple interactions decreases expression
ISO
Chloroquine inhibits the reaction [Artesunate results in decreased expression of SQSTM1 protein] Artesunate results in decreased expression of SQSTM1 mRNA; Artesunate results in decreased expression of SQSTM1 protein
CTD
PMID:30551460
NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
G
Srsf2
serine and arginine rich splicing factor 2
decreases response to substance
ISO
SRSF2 mRNA results in decreased susceptibility to artesunate
CTD
PMID:20144594
NCBI chr10:102,052,158...102,055,365
Ensembl chr10:102,052,314...102,055,338
G
Timp1
TIMP metallopeptidase inhibitor 1
increases expression multiple interactions
ISO
Artesunate results in increased expression of TIMP1 mRNA Chloroquine inhibits the reaction [Artesunate results in increased expression of TIMP1 mRNA]
CTD
PMID:30551460
NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664
G
Tlr4
toll-like receptor 4
multiple interactions
EXP
artesunate inhibits the reaction [Glucose results in increased expression of TLR4 protein]
CTD
PMID:30031708
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
G
Tnf
tumor necrosis factor
multiple interactions
EXP
artesunate inhibits the reaction [Ethanol results in increased expression of TNF protein]; artesunate inhibits the reaction [Glucose results in increased expression of TNF mRNA]; artesunate inhibits the reaction [Glucose results in increased secretion of TNF protein]
CTD
PMID:27474069 PMID:30031708
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Tp53
tumor protein p53
increases expression multiple interactions
ISO
Artesunate results in increased expression of TP53 protein Artesunate inhibits the reaction [TPT1 protein binds to TP53 protein]
CTD
PMID:33259807
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
G
Tpt1
tumor protein, translationally-controlled 1
affects response to substance multiple interactions
ISO
TPT1 protein affects the susceptibility to artesunate Artesunate binds to and results in decreased expression of TPT1 protein; Artesunate inhibits the reaction [TPT1 protein binds to TP53 protein]
CTD
PMID:15878303 PMID:33259807
NCBI chr15:51,156,728...51,159,629
Ensembl chr15:51,146,154...51,159,625
G
Tufm
Tu translation elongation factor, mitochondrial
decreases response to substance
ISO
TUFM mRNA results in decreased susceptibility to artesunate
CTD
PMID:20144594
NCBI chr 1:181,073,788...181,077,395
Ensembl chr 1:181,073,788...181,077,395
G
Ulk1
unc-51 like autophagy activating kinase 1
increases phosphorylation multiple interactions
ISO
Artesunate results in increased phosphorylation of ULK1 protein acadesine promotes the reaction [Artesunate results in increased phosphorylation of ULK1 protein]; Acetylcysteine inhibits the reaction [Artesunate results in increased phosphorylation of ULK1 protein]; dorsomorphin inhibits the reaction [Artesunate results in increased phosphorylation of ULK1 protein]
CTD
PMID:33002460
NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966
G
Vegfa
vascular endothelial growth factor A
multiple interactions
EXP
artesunate inhibits the reaction [1,2-Dimethylhydrazine results in increased expression of VEGFA protein]
CTD
PMID:29031619
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
G
Yy1
YY1 transcription factor
decreases expression
ISO
artesunate results in decreased expression of YY1 protein
CTD
PMID:19513562
NCBI chr 6:127,706,739...127,736,499
Ensembl chr 6:127,707,596...127,732,747
G
Zbtb4
zinc finger and BTB domain containing 4
increases response to substance
ISO
ZBTB4 mRNA results in increased susceptibility to artesunate
CTD
PMID:20144594
NCBI chr10:54,480,698...54,501,492
Ensembl chr10:54,485,071...54,501,492
G
Mpo
myeloperoxidase
decreases activity
ISO
balsalazide results in decreased activity of MPO protein
CTD
PMID:19296261
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
G
Abcg2
ATP binding cassette subfamily G member 2
affects transport multiple interactions
ISO
ABCG2 protein affects the transport of Cimetidine Cimetidine inhibits the reaction [ABCG2 protein results in increased export of bisbenzimide ethoxide trihydrochloride]
CTD
PMID:15365089 PMID:15722455 PMID:26907376
NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
G
Adh1c
alcohol dehydrogenase 1C (class I), gamma polypeptide
multiple interactions
ISO
Cimetidine inhibits the reaction [ADH1C protein results in increased oxidation of Ethanol]
CTD
PMID:23220590
NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892
G
Adh4
alcohol dehydrogenase 4 (class II), pi polypeptide
multiple interactions
ISO
Cimetidine inhibits the reaction [ADH4 protein results in increased oxidation of Ethanol]
CTD
PMID:23220590
NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591
G
Adh5
alcohol dehydrogenase 5 (class III), chi polypeptide
multiple interactions
ISO
Cimetidine inhibits the reaction [ADH5 protein results in increased oxidation of S-hydroxymethylglutathione]
CTD
PMID:23220590
NCBI chr 2:226,975,184...226,987,591
Ensembl chr 2:226,947,466...226,987,591
G
Adh7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
multiple interactions
ISO
Cimetidine inhibits the reaction [ADH7 protein results in increased oxidation of Ethanol]
CTD
PMID:23220590
NCBI chr 2:226,748,724...226,763,183
Ensembl chr 2:226,741,788...226,763,182
G
Adipoq
adiponectin, C1Q and collagen domain containing
multiple interactions
ISO
Cimetidine promotes the reaction [Metformin results in decreased expression of ADIPOQ mRNA]
CTD
PMID:20956498
NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
G
Ahr
aryl hydrocarbon receptor
affects expression multiple interactions
ISO
Cimetidine affects the expression of AHR protein [Monocrotophos co-treated with Cimetidine] results in increased expression of AHR protein
CTD
PMID:22733800
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
G
Aldh1a1
aldehyde dehydrogenase 1 family, member A1
multiple interactions
ISO
Cimetidine inhibits the reaction [ALDH1A1 protein results in increased oxidation of Acetaldehyde]
CTD
PMID:23220590
NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
G
Aldh3a1
aldehyde dehydrogenase 3 family, member A1
multiple interactions
ISO
Cimetidine inhibits the reaction [ALDH3A1 protein results in increased oxidation of benzaldehyde]
CTD
PMID:23220590
NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681
G
Apaf1
apoptotic peptidase activating factor 1
increases activity
ISO
Cimetidine results in increased activity of APAF1 protein
CTD
PMID:17273750
NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
G
Ar
androgen receptor
multiple interactions decreases expression
ISO EXP
Cimetidine inhibits the reaction [Dihydrotestosterone binds to AR protein] Cimetidine results in decreased expression of AR protein
CTD
PMID:6835285 PMID:26021711
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
G
Bax
BCL2 associated X, apoptosis regulator
increases expression multiple interactions
ISO
Cimetidine results in increased expression of BAX protein Cimetidine inhibits the reaction [Ethanol results in increased expression of BAX protein]
CTD
PMID:20127008 PMID:27983966
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
G
Bcl2
BCL2, apoptosis regulator
decreases expression multiple interactions
ISO
Cimetidine results in decreased expression of BCL2 protein Cimetidine inhibits the reaction [Ethanol results in decreased expression of BCL2 protein]
CTD
PMID:20127008 PMID:27983966
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
G
Casp1
caspase 1
increases activity multiple interactions
ISO
Cimetidine results in increased activity of CASP1 protein CASP1 protein affects the reaction [Cimetidine results in increased expression of IL18 protein]
CTD
PMID:16723495
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
G
Casp12
caspase 12
multiple interactions
ISO
Cimetidine inhibits the reaction [Ethanol results in increased expression of CASP12 protein]
CTD
PMID:27983966
NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
G
Casp3
caspase 3
increases activity multiple interactions increases expression
ISO EXP
Cimetidine results in increased activity of CASP3 protein Cimetidine inhibits the reaction [Ethanol results in increased expression of CASP3 protein] Cimetidine results in increased expression of CASP3 protein
CTD
PMID:17273750 PMID:20127008 PMID:26021711 PMID:27983966
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
G
Casp7
caspase 7
increases activity
ISO
Cimetidine results in increased activity of CASP7 protein
CTD
PMID:17273750
NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
G
Casp8
caspase 8
increases activity
ISO
Cimetidine results in increased activity of CASP8 protein
CTD
PMID:17273750 PMID:20127008
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
G
Casp9
caspase 9
increases activity
ISO
Cimetidine results in increased activity of CASP9 protein
CTD
PMID:17273750 PMID:20127008
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
G
Ccl2
C-C motif chemokine ligand 2
multiple interactions
ISO
Cimetidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CCL2 protein]
CTD
PMID:12107048
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Cd14
CD14 molecule
decreases expression
ISO
Cimetidine results in decreased expression of CD14 protein
CTD
PMID:11556524
NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
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Cst3
cystatin C
multiple interactions
ISO
Cimetidine inhibits the reaction [Cisplatin results in increased expression of CST3]
CTD
PMID:22525860
NCBI chr 3:136,336,923...136,340,796
Ensembl chr 3:136,336,920...136,340,822
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Ctsd
cathepsin D
decreases activity
EXP
Cimetidine results in decreased activity of CTSD protein
CTD
PMID:12903910
NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
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Ctsl
cathepsin L
decreases activity
EXP
Cimetidine results in decreased activity of CTSL protein
CTD
PMID:12903910
NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions decreases expression decreases activity
ISO
Cimetidine inhibits the reaction [Cocaine results in increased expression of CYP1A1 protein] Cimetidine results in decreased expression of CYP1A1 protein [Monocrotophos co-treated with Cimetidine] results in increased expression of CYP1A1 protein Cimetidine results in decreased activity of CYP1A1 protein
CTD
PMID:11856816 PMID:22733800
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
multiple interactions decreases activity
ISO
Cimetidine inhibits the reaction [CYP1A2 protein results in increased metabolism of Tacrine]; NADP promotes the reaction [Cimetidine inhibits the reaction [CYP1A2 protein results in increased metabolism of Tacrine]]; styrofoam analog promotes the reaction [Cimetidine results in decreased activity of CYP1A2 protein]
CTD
PMID:7946932 PMID:19909766 PMID:31863871
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
decreases expression multiple interactions decreases activity
ISO
Cimetidine results in decreased expression of CYP2B6 protein [Monocrotophos co-treated with Cimetidine] results in increased expression of CYP2B6 protein Cimetidine results in decreased activity of CYP2B6 protein
CTD
PMID:22733800
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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Cyp2c11
cytochrome P450, subfamily 2, polypeptide 11
multiple interactions decreases activity
EXP ISO
Cimetidine inhibits the reaction [CYP2C11 protein results in increased glutathionylation of lamotrigine] Cimetidine results in decreased activity of CYP2C9 protein styrofoam analog promotes the reaction [Cimetidine results in decreased activity of CYP2C9 protein]
CTD
PMID:19909766 PMID:19961160
NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
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Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
decreases activity multiple interactions
ISO EXP
Cimetidine results in decreased activity of CYP2D6 protein Cimetidine inhibits the reaction [CYP2D6 protein results in increased metabolism of Dextromethorphan] styrofoam analog promotes the reaction [Cimetidine results in decreased activity of CYP2D6 protein]
CTD
PMID:17651725 PMID:19909766
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
decreases expression multiple interactions
ISO
Cimetidine results in decreased expression of CYP2E1 protein [Monocrotophos co-treated with Cimetidine] results in increased expression of CYP2E1 protein
CTD
PMID:22733800
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Cyp2j4
cytochrome P450, family 2, subfamily j, polypeptide 4
multiple interactions
ISO
Cimetidine inhibits the reaction [Cocaine results in increased expression of CYP2J2 protein]
CTD
PMID:11856816
NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
multiple interactions decreases expression decreases activity
ISO
[Monocrotophos co-treated with Cimetidine] results in increased expression of CYP3A4 protein; Cimetidine inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Nifedipine]; styrofoam analog promotes the reaction [Cimetidine results in decreased activity of CYP3A4 protein] Cimetidine results in decreased expression of CYP3A4 protein
CTD
PMID:2271712 PMID:16041596 PMID:18846481 PMID:19909766 PMID:22733800
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Ddit3
DNA-damage inducible transcript 3
multiple interactions
ISO
Cimetidine inhibits the reaction [Ethanol results in increased expression of DDIT3 protein]
CTD
PMID:27983966
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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Egfr
epidermal growth factor receptor
multiple interactions
ISO
Cimetidine inhibits the reaction [EGFR protein results in increased phosphorylation of EGFR protein] [Cimetidine results in decreased abundance of Cyclic AMP] inhibits the reaction [EGFR protein results in increased phosphorylation of EGFR protein]
CTD
PMID:17295779
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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Fshb
follicle stimulating hormone subunit beta
affects expression
ISO
Cimetidine affects the expression of FSHB protein
CTD
PMID:435711
NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
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Gast
gastrin
affects expression
ISO
Cimetidine affects the expression of GAST protein
CTD
PMID:12503773
NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496
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Gstp1
glutathione S-transferase pi 1
affects expression multiple interactions
ISO
Cimetidine affects the expression of GSTP1 protein [Monocrotophos co-treated with Cimetidine] results in increased expression of GSTP1 protein
CTD
PMID:22733800
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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Hmox1
heme oxygenase 1
multiple interactions
EXP
[piperine co-treated with Cimetidine co-treated with Pyruvates] inhibits the reaction [Puromycin Aminonucleoside results in increased expression of HMOX1 protein]
CTD
PMID:12806184
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Hrh1
histamine receptor H 1
multiple interactions
ISO
Cimetidine inhibits the reaction [HRH1 results in decreased susceptibility to Morphine]
CTD
PMID:14569158
NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455
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Hrh2
histamine receptor H 2
multiple interactions decreases activity increases expression
ISO EXP
[Cimetidine binds to and results in decreased activity of HRH2 protein] results in decreased susceptibility to [Histamine co-treated with [Oxygen deficiency co-treated with Oxygen]]; [Cimetidine binds to and results in decreased activity of HRH2 protein] which affects the susceptibility to Metformin; [Cimetidine binds to and results in decreased activity of HRH2 protein] which results in decreased abundance of Cyclic AMP; Burimamide inhibits the reaction [[Cyclic AMP binds to and results in decreased activity of HRH2 protein] which results in decreased abundance of Cimetidine]; Cimetidine binds to and results in decreased activity of HRH2 protein; Cimetidine binds to and results in increased activity of HRH2 protein; Cimetidine inhibits the reaction [HRH2 protein promotes the reaction [Histamine results in increased expression of IL16 protein]] Cimetidine results in decreased activity of HRH2 protein [Cimetidine binds to and results in decreased activity of HRH2 protein] which results in decreased susceptibility to clobenpropit; Cimetidine binds to and results in decreased activity of HRH2 protein; Cimetidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH2 protein] which results in decreased susceptibility to Scopolamine] Cimetidine binds to and results in increased activity of HRH2 protein; Cimetidine inhibits the reaction [HRH2 results in decreased susceptibility to Morphine]; HRH2 protein affects the reaction [Cimetidine results in increased expression of IL18 protein] Cimetidine results in increased expression of HRH2 protein
CTD
PMID:1912125 PMID:2461127 PMID:6522242 PMID:9681472 PMID:12235264 PMID:14569158 PMID:15961859 PMID:16488453 PMID:16632449 PMID:16723495 PMID:19215234 PMID:21276809 PMID:22926047 More...
NCBI chr17:10,366,004...10,407,791
Ensembl chr17:10,368,298...10,407,631
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Hspa5
heat shock protein family A (Hsp70) member 5
multiple interactions
ISO
Cimetidine inhibits the reaction [Ethanol results in increased expression of HSPA5 protein]
CTD
PMID:27983966
NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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Icam1
intercellular adhesion molecule 1
decreases expression
ISO
Cimetidine results in decreased expression of ICAM1 protein
CTD
PMID:17189874
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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Ifng
interferon gamma
multiple interactions increases expression
ISO
Cimetidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]] Cimetidine results in increased expression of IFNG mRNA; Cimetidine results in increased expression of IFNG protein
CTD
PMID:10569698
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Il16
interleukin 16
multiple interactions
ISO
Cimetidine inhibits the reaction [HRH2 protein promotes the reaction [Histamine results in increased expression of IL16 protein]]
CTD
PMID:12235264
NCBI chr 1:137,617,702...137,718,022
Ensembl chr 1:137,617,944...137,718,130
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Il18
interleukin 18
multiple interactions increases expression
ISO
CASP1 protein affects the reaction [Cimetidine results in increased expression of IL18 protein]; Famotidine inhibits the reaction [Cimetidine results in increased expression of IL18 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Cimetidine results in increased expression of IL18 protein]; Ranitidine inhibits the reaction [Cimetidine results in increased expression of IL18 protein] HRH2 protein affects the reaction [Cimetidine results in increased expression of IL18 protein]
CTD
PMID:16723495
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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Il1b
interleukin 1 beta
multiple interactions
ISO
Cimetidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Cimetidine inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]
CTD
PMID:12065299
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Itga4
integrin subunit alpha 4
decreases expression
ISO
Cimetidine results in decreased expression of ITGA4 protein
CTD
PMID:11556524
NCBI chr 3:64,162,764...64,235,010
Ensembl chr 3:64,163,085...64,233,715
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Itgax
integrin subunit alpha X
decreases expression
ISO
Cimetidine results in decreased expression of ITGAX protein
CTD
PMID:11556524
NCBI chr 1:182,709,653...182,740,709
Ensembl chr 1:182,719,609...182,740,698
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Lrp1
LDL receptor related protein 1
decreases expression
ISO
Cimetidine results in decreased expression of LRP1 protein
CTD
PMID:11556524
NCBI chr 7:63,380,325...63,461,029
Ensembl chr 7:63,380,356...63,460,910
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Ncam1
neural cell adhesion molecule 1
decreases expression
ISO
Cimetidine results in decreased expression of NCAM mRNA; Cimetidine results in decreased expression of NCAM protein
CTD
PMID:17273750
NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014
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Nfkb1
nuclear factor kappa B subunit 1
multiple interactions
ISO
Cimetidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Cimetidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of NFKB1 protein]
CTD
PMID:12065299 PMID:12107048
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
decreases expression multiple interactions
ISO
Cimetidine results in decreased expression of NR1I2 protein [Monocrotophos co-treated with Cimetidine] results in increased expression of NR1I2 protein
CTD
PMID:22733800
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Nr1i3
nuclear receptor subfamily 1, group I, member 3
decreases expression multiple interactions
ISO
Cimetidine results in decreased expression of NR1I3 protein [Monocrotophos co-treated with Cimetidine] results in increased expression of NR1I3 protein
CTD
PMID:22733800
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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Ntf3
neurotrophin 3
multiple interactions
EXP
Cimetidine inhibits the reaction [Histamine results in increased expression of NTF3 protein]
CTD
PMID:21276809
NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596
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Pde4b
phosphodiesterase 4B
multiple interactions
ISO
Cimetidine inhibits the reaction [Histamine results in increased expression of PDE4B mRNA]
CTD
PMID:11131300
NCBI chr 5:116,799,819...117,369,155
Ensembl chr 5:116,799,971...117,367,696
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Prl
prolactin
affects expression
ISO
Cimetidine affects the expression of PRL protein
CTD
PMID:435711 PMID:9037573
NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
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Prok1
prokineticin 1
decreases expression
EXP
Cimetidine results in decreased expression of PROK1 protein
CTD
PMID:26021711
NCBI chr 2:194,850,539...194,859,343
Ensembl chr 2:194,853,991...194,859,250
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
Cimetidine inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; Cimetidine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of and results in increased activity of RELA protein] Cimetidine inhibits the reaction [Ethanol results in increased expression of RELA protein]
CTD
PMID:12065299 PMID:12107048 PMID:24300194
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Selp
selectin P
decreases expression
ISO
Cimetidine results in decreased expression of SELP protein
CTD
PMID:17189874
NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845
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Slc22a1
solute carrier family 22 member 1
increases uptake multiple interactions
EXP ISO
SLC22A1 protein results in increased uptake of Cimetidine Cimetidine inhibits the reaction [SLC22A1 protein results in increased uptake of Ethidium]
CTD
PMID:16006492 PMID:19357179
NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
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Slc22a2
solute carrier family 22 member 2
multiple interactions increases transport decreases response to substance increases uptake
ISO EXP
1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A2 protein results in increased uptake of Cimetidine]; Cimetidine inhibits the reaction [SLC22A2 protein affects the transport of Tetraethylammonium]; Cimetidine inhibits the reaction [SLC22A2 protein polymorphism results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Cimetidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Cimetidine inhibits the reaction [SLC22A2 protein results in increased uptake of Ethidium]; p-Aminohippuric Acid inhibits the reaction [SLC22A2 protein results in increased uptake of Cimetidine] SLC22A2 protein results in increased transport of Cimetidine SLC22A2 gene polymorphism results in decreased susceptibility to Cimetidine
CTD
PMID:15496291 PMID:16006492 PMID:18230276 PMID:19357179 PMID:21599003 PMID:22525860 More...
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Slc22a3
solute carrier family 22 member 3
multiple interactions increases transport
ISO
Cimetidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Cimetidine inhibits the reaction [SLC22A3 protein results in increased uptake of Ethidium]; Cimetidine inhibits the reaction [SLC22A3 protein results in increased uptake of Metformin] Cimetidine inhibits the reaction [SLC22A3 protein results in increased uptake of Tetraethylammonium] SLC22A3 protein results in increased transport of Cimetidine
CTD
PMID:10966924 PMID:18253050 PMID:19357179 PMID:21697722
NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
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Slc22a6
solute carrier family 22 member 6
multiple interactions increases uptake
ISO
1-Methyl-4-phenylpyridinium inhibits the reaction [SLC22A6 protein results in increased uptake of Cimetidine]; Cimetidine inhibits the reaction [SLC22A6 protein affects the transport of p-Aminohippuric Acid]; p-Aminohippuric Acid inhibits the reaction [SLC22A6 protein results in increased uptake of Cimetidine]
CTD
PMID:15496291 PMID:16006492 PMID:16098483
NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
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Slc22a7
solute carrier family 22 member 7
increases uptake multiple interactions
ISO
SLC22A7 protein results in increased uptake of Cimetidine Cimetidine inhibits the reaction [SLC22A7 protein results in increased uptake of Glutarates]
CTD
PMID:12065749 PMID:16006492
NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921
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Slc22a8
solute carrier family 22 member 8
multiple interactions increases uptake affects transport
ISO EXP
Cimetidine inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Probenecid inhibits the reaction [SLC22A8 protein affects the transport of Cimetidine] SLC22A8 protein results in increased uptake of Cimetidine Cimetidine inhibits the reaction [SLC22A8 protein results in increased uptake of p-Aminohippuric Acid] estradiol-17 beta-glucuronide inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; estrone sulfate inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; Famotidine inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; p-Aminohippuric Acid inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; Penicillin G inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; Probenecid inhibits the reaction [SLC22A8 protein affects the transport of Cimetidine]; Probenecid promotes the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; Ranitidine inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]
CTD
PMID:10224140 PMID:11306713 PMID:15100168 PMID:15319347 PMID:15496291 PMID:16006492 PMID:16098483 More...
NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
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Slc47a1
solute carrier family 47 member 1
affects transport multiple interactions decreases activity
ISO
SLC47A1 protein affects the transport of Cimetidine Cimetidine inhibits the reaction [SLC47A1 protein results in increased uptake of Cadmium] Cimetidine inhibits the reaction [SLC47A1 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Cimetidine inhibits the reaction [SLC47A1 protein results in increased uptake of Cadmium] Cimetidine results in decreased activity of SLC47A1 protein
CTD
PMID:16928787 PMID:21599003 PMID:27871888
NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
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Slc47a2
solute carrier family 47 member 2
multiple interactions
ISO
Cimetidine inhibits the reaction [SLC47A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Cimetidine inhibits the reaction [SLC47A2 protein results in increased uptake of Cadmium]
CTD
PMID:21599003 PMID:27871888
NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904
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Slc9a3
solute carrier family 9 member A3
multiple interactions
EXP
[piperine co-treated with Cimetidine co-treated with Pyruvates] inhibits the reaction [Puromycin Aminonucleoside results in decreased expression of SLC9A3 protein]
CTD
PMID:12806184
NCBI chr 1:29,124,633...29,167,912
Ensembl chr 1:29,124,674...29,167,417
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Tnf
tumor necrosis factor
multiple interactions
ISO
Cimetidine inhibits the reaction [Dimaprit inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]] Cimetidine inhibits the reaction [Cocaine results in increased expression of TNF protein]
CTD
PMID:9088875 PMID:11856816
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Abcb11
ATP binding cassette subfamily B member 11
decreases activity
ISO
Cisapride results in decreased activity of ABCB11 protein
CTD
PMID:23956101
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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Acp5
acid phosphatase 5, tartrate resistant
multiple interactions
ISO
Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]
CTD
PMID:31150804
NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929
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Ctsk
cathepsin K
multiple interactions
ISO
Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]
CTD
PMID:31150804
NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550
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Cyp2c11
cytochrome P450, subfamily 2, polypeptide 11
decreases activity
ISO
Cisapride results in decreased activity of CYP2C9 protein
CTD
PMID:15306208
NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
multiple interactions affects metabolic processing affects chemical synthesis decreases activity
ISO
Cisapride inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] CYP3A4 protein affects the metabolism of Cisapride CYP3A4 protein affects the chemical synthesis of Cisapride metabolite Cisapride results in decreased activity of CYP3A4 protein
CTD
PMID:11717173 PMID:15306208 PMID:19299527
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Dcstamp
dendrocyte expressed seven transmembrane protein
multiple interactions
ISO
Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA]
CTD
PMID:31150804
NCBI chr 7:70,807,455...70,822,067
Ensembl chr 7:70,807,581...70,822,078
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions
ISO
Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]
CTD
PMID:31150804
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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Kcnh2
potassium voltage-gated channel subfamily H member 2
multiple interactions decreases activity affects localization affects binding
ISO
beta-Cyclodextrins analog inhibits the reaction [Cisapride results in decreased activity of KCNH2 protein]; Cisapride binds to and results in decreased activity of KCNH2 protein; Cisapride inhibits the reaction [KCNH2 protein results in increased transport of Thallium] Cisapride affects the localization of KCNH2 protein mutant form Cisapride binds to KCNH2 protein
CTD
PMID:9395068 PMID:10531299 PMID:11005845 PMID:11741928 PMID:12388285 PMID:15272206 PMID:15306208 PMID:15671647 PMID:15740727 PMID:17513944 PMID:18701618 PMID:19260734 PMID:19583963 PMID:21158687 PMID:24052561 PMID:24830940 PMID:27553911 PMID:28551711 PMID:30561737 More...
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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Nfatc1
nuclear factor of activated T-cells 1
multiple interactions
ISO
Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]
CTD
PMID:31150804
NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028
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Scn5a
sodium voltage-gated channel alpha subunit 5
increases localization
ISO
Cisapride results in increased localization of SCN5A protein mutant form
CTD
PMID:16301357
NCBI chr 8:119,220,905...119,318,816
Ensembl chr 8:119,220,905...119,318,769
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Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Cisapride inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Tnfsf11
TNF superfamily member 11
multiple interactions
ISO
Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]; Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA]; Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of FOS mRNA]; Cisapride inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]
CTD
PMID:31150804
NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445
G
Acta2
actin alpha 2, smooth muscle
affects expression
ISO
diethyl malate affects the expression of ACTA2 mRNA
CTD
PMID:24814887
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
G
Actc1
actin, alpha, cardiac muscle 1
affects expression
ISO
diethyl malate affects the expression of ACTC1 mRNA
CTD
PMID:24814887
NCBI chr 3:100,811,987...100,817,523
Ensembl chr 3:100,811,987...100,817,523
G
Actn3
actinin alpha 3
affects expression
ISO
diethyl malate affects the expression of ACTN3 mRNA
CTD
PMID:24814887
NCBI chr 1:202,159,081...202,175,012
Ensembl chr 1:202,159,082...202,175,012
G
Adcy1
adenylate cyclase 1
affects expression
ISO
diethyl malate affects the expression of ADCY1 mRNA
CTD
PMID:24814887
NCBI chr14:81,911,240...82,020,594
Ensembl chr14:81,911,099...82,028,969
G
Adh1c
alcohol dehydrogenase 1C (class I), gamma polypeptide
affects expression
ISO
diethyl malate affects the expression of ADH1 mRNA
CTD
PMID:24814887
NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892
G
Agt
angiotensinogen
affects expression
ISO
diethyl malate affects the expression of AGT mRNA
CTD
PMID:24814887
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
G
C3
complement C3
affects expression
ISO
diethyl malate affects the expression of C3 mRNA
CTD
PMID:24814887
NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
G
Cacnb2
calcium voltage-gated channel auxiliary subunit beta 2
affects expression
ISO
diethyl malate affects the expression of CACNB2 mRNA
CTD
PMID:24814887
NCBI chr17:77,564,630...77,910,000
Ensembl chr17:77,564,460...77,909,106
G
Cacnb4
calcium voltage-gated channel auxiliary subunit beta 4
affects expression
ISO
diethyl malate affects the expression of CACNB4 mRNA
CTD
PMID:24814887
NCBI chr 3:36,906,771...37,169,165
Ensembl chr 3:36,910,427...37,168,944
G
Camk2a
calcium/calmodulin-dependent protein kinase II alpha
multiple interactions affects expression
ISO
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of CAMK2A mRNA]
CTD
PMID:24814887
NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
G
Cbr2
carbonyl reductase 2
affects expression
ISO
diethyl malate affects the expression of CBR2 mRNA
CTD
PMID:24814887
NCBI chr10:106,008,535...106,012,838
Ensembl chr10:105,991,589...106,013,001
G
Ccl20
C-C motif chemokine ligand 20
affects expression
ISO
diethyl malate affects the expression of CCL20 mRNA
CTD
PMID:24814887
NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
G
Ccl7
C-C motif chemokine ligand 7
affects expression
ISO
diethyl malate affects the expression of CCL7 mRNA
CTD
PMID:24814887
NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
G
Ccl9
C-C motif chemokine ligand 9
affects expression
ISO
diethyl malate affects the expression of CCL6 mRNA
CTD
PMID:24814887
NCBI chr10:68,366,486...68,371,408
Ensembl chr10:68,366,487...68,371,369
G
Col11a1
collagen type XI alpha 1 chain
affects expression
ISO
diethyl malate affects the expression of COL11A1 mRNA
CTD
PMID:24814887
NCBI chr 2:201,820,715...202,013,853
Ensembl chr 2:201,820,715...202,013,853
G
Col2a1
collagen type II alpha 1 chain
affects expression
ISO
diethyl malate affects the expression of COL2A1 mRNA
CTD
PMID:24814887
NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546
G
Col3a1
collagen type III alpha 1 chain
affects expression
ISO
diethyl malate affects the expression of COL3A1 mRNA
CTD
PMID:24814887
NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
G
Col6a1
collagen type VI alpha 1 chain
affects expression
ISO
diethyl malate affects the expression of COL6A1 mRNA
CTD
PMID:24814887
NCBI chr20:11,906,105...11,924,599
Ensembl chr20:11,905,957...11,924,597
G
Comp
cartilage oligomeric matrix protein
affects expression
ISO
diethyl malate affects the expression of COMP mRNA
CTD
PMID:24814887
NCBI chr16:19,047,206...19,055,584
Ensembl chr16:19,047,207...19,055,845
G
Cxcl12
C-X-C motif chemokine ligand 12
affects expression multiple interactions
ISO
diethyl malate affects the expression of CXCL12 mRNA S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of CXCL12 mRNA]
CTD
PMID:24814887
NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
G
Cxcl3
C-X-C motif chemokine ligand 3
affects expression
ISO
diethyl malate affects the expression of CXCL1 mRNA
CTD
PMID:24814887
NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
G
Cxcl6
C-X-C motif chemokine ligand 6
affects expression
ISO
diethyl malate affects the expression of CXCL5 mRNA
CTD
PMID:24814887
NCBI chr14:17,310,790...17,312,250
Ensembl chr14:17,310,426...17,313,093
G
Cyp2j4
cytochrome P450, family 2, subfamily j, polypeptide 4
affects expression
ISO
diethyl malate affects the expression of CYP2J9 mRNA
CTD
PMID:24814887
NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
G
Dapk2
death-associated protein kinase 2
affects expression
ISO
diethyl malate affects the expression of DAPK2 mRNA
CTD
PMID:24814887
NCBI chr 8:66,706,536...66,825,567
Ensembl chr 8:66,706,609...66,825,567
G
Dhrs3
dehydrogenase/reductase 3
affects expression
ISO
diethyl malate affects the expression of DHRS3 mRNA
CTD
PMID:24814887
NCBI chr 5:156,747,939...156,782,420
Ensembl chr 5:156,747,962...156,782,417
G
Dhx58
DEXH-box helicase 58
affects expression
ISO
diethyl malate affects the expression of DHX58 mRNA
CTD
PMID:24814887
NCBI chr10:85,620,352...85,631,776
Ensembl chr10:85,620,357...85,631,525
G
Edar
ectodysplasin-A receptor
affects expression
ISO
diethyl malate affects the expression of EDAR mRNA
CTD
PMID:24814887
NCBI chr20:26,587,836...26,666,543
Ensembl chr20:26,587,839...26,666,494
G
Ednra
endothelin receptor type A
affects expression
ISO
diethyl malate affects the expression of EDNRA mRNA
CTD
PMID:24814887
NCBI chr19:30,233,540...30,303,727
Ensembl chr19:30,233,571...30,297,049
G
Epas1
endothelial PAS domain protein 1
affects expression
ISO
diethyl malate affects the expression of EPAS1 mRNA
CTD
PMID:24814887
NCBI chr 6:7,790,236...7,871,717
Ensembl chr 6:7,790,647...7,871,228
G
Epha7
Eph receptor A7
affects expression
ISO
diethyl malate affects the expression of EPHA7 mRNA
CTD
PMID:24814887
NCBI chr 5:42,975,353...43,128,703
Ensembl chr 5:42,975,405...43,127,112
G
Ephb2
Eph receptor B2
affects expression
ISO
diethyl malate affects the expression of EPHB2 mRNA
CTD
PMID:24814887
NCBI chr 5:148,889,574...149,077,027
Ensembl chr 5:148,897,246...149,077,059
G
Ephb6
Eph receptor B6
affects expression
ISO
diethyl malate affects the expression of EPHB6 mRNA
CTD
PMID:24814887
NCBI chr 4:70,491,973...70,507,230
Ensembl chr 4:70,491,973...70,507,230
G
Fgf10
fibroblast growth factor 10
affects expression
ISO
diethyl malate affects the expression of FGF10 mRNA
CTD
PMID:24814887
NCBI chr 2:50,801,171...50,878,218
Ensembl chr 2:50,800,992...50,876,866
G
Fgf18
fibroblast growth factor 18
multiple interactions affects expression
ISO
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of FGF18 mRNA]
CTD
PMID:24814887
NCBI chr10:17,706,011...17,737,702
Ensembl chr10:17,706,174...17,736,818
G
Fgfr2
fibroblast growth factor receptor 2
affects expression
ISO
diethyl malate affects the expression of FGFR2 mRNA
CTD
PMID:24814887
NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626
G
Fst
follistatin
affects expression
ISO
diethyl malate affects the expression of FST mRNA
CTD
PMID:24814887
NCBI chr 2:46,123,260...46,130,584
Ensembl chr 2:46,123,439...46,130,571
G
Fzd2
frizzled class receptor 2
affects expression
ISO
diethyl malate affects the expression of FZD2 mRNA
CTD
PMID:24814887
NCBI chr10:87,561,866...87,563,776
Ensembl chr10:87,561,326...87,565,334
G
Fzd7
frizzled class receptor 7
affects expression
ISO
diethyl malate affects the expression of FZD7 mRNA
CTD
PMID:24814887
NCBI chr 9:60,931,433...60,934,252
Ensembl chr 9:60,930,875...60,935,781
G
Gclc
glutamate-cysteine ligase, catalytic subunit
affects expression
ISO
diethyl malate affects the expression of GCLC mRNA
CTD
PMID:24814887
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
G
Gclm
glutamate cysteine ligase, modifier subunit
multiple interactions affects expression
ISO
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of GCLM mRNA]
CTD
PMID:24814887
NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
G
Ggt6
gamma-glutamyl transferase 6
affects expression
ISO
diethyl malate affects the expression of GGT6 mRNA
CTD
PMID:24814887
NCBI chr10:57,051,977...57,054,900
Ensembl chr10:57,051,825...57,067,260
G
Gli2
GLI family zinc finger 2
affects expression
ISO
diethyl malate affects the expression of GLI2 mRNA
CTD
PMID:24814887
NCBI chr13:29,946,882...30,163,589
Ensembl chr13:29,946,809...30,163,574
G
Gnao1
G protein subunit alpha o1
affects expression
ISO
diethyl malate affects the expression of GNAO1 mRNA
CTD
PMID:24814887
NCBI chr19:11,034,874...11,192,531
Ensembl chr19:11,035,956...11,192,493
G
Gng7
G protein subunit gamma 7
affects expression
ISO
diethyl malate affects the expression of GNG7 mRNA
CTD
PMID:24814887
NCBI chr 7:8,697,458...8,761,239
Ensembl chr 7:8,697,521...8,761,240
G
Gsr
glutathione-disulfide reductase
affects expression
ISO
diethyl malate affects the expression of GSR mRNA
CTD
PMID:24814887
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
G
Gss
glutathione synthetase
multiple interactions affects expression
ISO
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of GSS mRNA]
CTD
PMID:24814887
NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198
G
Gsta5
glutathione S-transferase alpha 5
multiple interactions affects expression
ISO
S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of GSTA1 mRNA]
CTD
PMID:24814887
NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
G
Gucy1a1
guanylate cyclase 1 soluble subunit alpha 1
affects expression
ISO
diethyl malate affects the expression of GUCY1A1 mRNA
CTD
PMID:24814887
NCBI chr 2:167,418,615...167,482,293
Ensembl chr 2:167,418,640...167,481,671
G
Gucy1b1
guanylate cyclase 1 soluble subunit beta 1
affects expression
ISO
diethyl malate affects the expression of GUCY1B1 mRNA
CTD
PMID:24814887
NCBI chr 2:167,348,824...167,398,983
Ensembl chr 2:167,348,825...167,398,916
G
Hck
HCK proto-oncogene, Src family tyrosine kinase
affects expression
ISO
diethyl malate affects the expression of HCK mRNA
CTD
PMID:24814887
NCBI chr 3:141,571,587...141,614,696
Ensembl chr 3:141,571,587...141,614,693
G
Hgf
hepatocyte growth factor
affects expression
ISO
diethyl malate affects the expression of HGF mRNA
CTD
PMID:24814887
NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
G
Igf1
insulin-like growth factor 1
affects expression
ISO
diethyl malate affects the expression of IGF1 mRNA
CTD
PMID:24814887
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
G
Il15
interleukin 15
affects expression
ISO
diethyl malate affects the expression of IL15 mRNA
CTD
PMID:24814887
NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820
G
Il18
interleukin 18
affects expression
ISO
diethyl malate affects the expression of IL18 mRNA
CTD
PMID:24814887
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
G
Irag1
inositol 1,4,5-triphosphate receptor associated 1
affects expression
ISO
diethyl malate affects the expression of IRAG1 mRNA
CTD
PMID:24814887
NCBI chr 1:164,981,716...165,094,232
Ensembl chr 1:164,981,716...165,094,176
G
Irf7
interferon regulatory factor 7
affects expression
ISO
diethyl malate affects the expression of IRF7 mRNA
CTD
PMID:24814887
NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832
G
Isg15
ISG15 ubiquitin-like modifier
affects expression
ISO
diethyl malate affects the expression of ISG15 mRNA
CTD
PMID:24814887
NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435
G
Itga11
integrin subunit alpha 11
affects expression
ISO
diethyl malate affects the expression of ITGA11 mRNA
CTD
PMID:24814887
NCBI chr 8:63,145,998...63,254,714
Ensembl chr 8:63,146,001...63,254,407
G
Itga3
integrin subunit alpha 3
affects expression
ISO
diethyl malate affects the expression of ITGA3 mRNA
CTD
PMID:24814887
NCBI chr10:79,990,160...80,022,206
Ensembl chr10:79,990,161...80,022,118
G
Kcnmb4
potassium calcium-activated channel subfamily M regulatory beta subunit 4
affects expression
ISO
diethyl malate affects the expression of KCNMB4 mRNA
CTD
PMID:24814887
NCBI chr 7:52,066,145...52,119,098
Ensembl chr 7:52,066,136...52,119,278
G
Lama1
laminin subunit alpha 1
affects expression
ISO
diethyl malate affects the expression of LAMA1 mRNA
CTD
PMID:24814887
NCBI chr 9:107,692,770...107,816,847
Ensembl chr 9:107,692,770...107,817,478
G
Lama4
laminin subunit alpha 4
affects expression
ISO
diethyl malate affects the expression of LAMA4 mRNA
CTD
PMID:24814887
NCBI chr20:42,392,268...42,533,347
Ensembl chr20:42,392,268...42,533,347
G
Mapk1
mitogen activated protein kinase 1
affects phosphorylation multiple interactions
ISO
diethyl malate affects the phosphorylation of MAPK1 protein S-ethyl glutathione inhibits the reaction [diethyl malate affects the phosphorylation of MAPK1 protein]
CTD
PMID:24814887
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
G
Mapk3
mitogen activated protein kinase 3
affects phosphorylation multiple interactions
ISO
diethyl malate affects the phosphorylation of MAPK3 protein S-ethyl glutathione inhibits the reaction [diethyl malate affects the phosphorylation of MAPK3 protein]
CTD
PMID:24814887
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
G
Myl9
myosin light chain 9
affects expression
ISO
diethyl malate affects the expression of MYL9 mRNA
CTD
PMID:24814887
NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333
G
Odc1
ornithine decarboxylase 1
affects expression
ISO
diethyl malate affects the expression of ODC1 mRNA
CTD
PMID:24814887
NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
G
Pdgfb
platelet derived growth factor subunit B
affects expression multiple interactions
ISO
diethyl malate affects the expression of PDGFB mRNA S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of PDGFB mRNA]
CTD
PMID:24814887
NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984
G
Pdgfd
platelet derived growth factor D
affects expression
ISO
diethyl malate affects the expression of PDGFD mRNA
CTD
PMID:24814887
NCBI chr 8:3,488,448...3,722,395
Ensembl chr 8:3,488,423...3,722,395
G
Pf4
platelet factor 4
affects expression
ISO
diethyl malate affects the expression of PF4 mRNA
CTD
PMID:24814887
NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365
G
Pik3ip1
phosphoinositide-3-kinase interacting protein 1
affects expression
ISO
diethyl malate affects the expression of PIK3IP1 mRNA
CTD
PMID:24814887
NCBI chr14:78,204,668...78,216,616
Ensembl chr14:78,204,053...78,216,608
G
Plxnc1
plexin C1
affects expression
ISO
diethyl malate affects the expression of PLXNC1 mRNA
CTD
PMID:24814887
NCBI chr 7:29,390,038...29,543,985
Ensembl chr 7:29,390,048...29,543,779
G
Prkg1
protein kinase cGMP-dependent 1
affects expression
ISO
diethyl malate affects the expression of PRKG1 mRNA
CTD
PMID:24814887
NCBI chr 1:228,409,605...229,638,794
Ensembl chr 1:228,408,947...229,639,080
G
Ptgis
prostaglandin I2 synthase
affects expression
ISO
diethyl malate affects the expression of PTGIS mRNA
CTD
PMID:24814887
NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451
G
Ramp2
receptor activity modifying protein 2
affects expression
ISO
diethyl malate affects the expression of RAMP2 mRNA
CTD
PMID:24814887
NCBI chr10:86,187,366...86,190,692
Ensembl chr10:86,188,812...86,231,829
G
Rgs3
regulator of G-protein signaling 3
affects expression
ISO
diethyl malate affects the expression of RGS3 mRNA
CTD
PMID:24814887
NCBI chr 5:76,022,038...76,161,895
Ensembl chr 5:76,022,001...76,161,894
G
Rig1
RNA sensor RIG-1
affects expression
ISO
diethyl malate affects the expression of RIGI mRNA
CTD
PMID:24814887
NCBI chr 5:55,321,351...55,369,947
Ensembl chr 5:55,321,235...55,370,819
G
RT1-DMb
RT1 class II, locus DMb
affects expression
ISO
diethyl malate affects the expression of H2-DMB1 mRNA
CTD
PMID:24814887
NCBI chr20:4,693,102...4,700,340
Ensembl chr20:4,693,103...4,700,340
G
RT1-M3-1
RT1 class Ib, locus M3, gene 1
affects expression
ISO
diethyl malate affects the expression of H2-M3 mRNA
CTD
PMID:24814887
NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117
G
Runx1t1
RUNX1 partner transcriptional co-repressor 1
affects expression
ISO
diethyl malate affects the expression of RUNX1T1 mRNA
CTD
PMID:24814887
NCBI chr 5:27,187,674...27,338,070
Ensembl chr 5:27,187,551...27,335,592
G
Sema3b
semaphorin 3B
affects expression
ISO
diethyl malate affects the expression of SEMA3B mRNA
CTD
PMID:24814887
NCBI chr 8:108,271,663...108,280,326
Ensembl chr 8:108,271,666...108,282,919
G
Sema4g
semaphorin 4G
affects expression
ISO
diethyl malate affects the expression of SEMA4G mRNA
CTD
PMID:24814887
NCBI chr 1:243,849,979...243,865,343
Ensembl chr 1:243,853,854...243,865,341
G
Sema5a
semaphorin 5A
affects expression
ISO
diethyl malate affects the expression of SEMA5A mRNA
CTD
PMID:24814887
NCBI chr 2:83,309,843...83,741,084
Ensembl chr 2:83,309,843...83,741,084
G
Stat1
signal transducer and activator of transcription 1
affects expression
ISO
diethyl malate affects the expression of STAT1 mRNA
CTD
PMID:24814887
NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
G
Tgfb2
transforming growth factor, beta 2
affects expression multiple interactions
ISO
diethyl malate affects the expression of TGFB2 mRNA S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of TGFB2 mRNA]
CTD
PMID:24814887
NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
G
Thbs1
thrombospondin 1
affects expression
ISO
diethyl malate affects the expression of THBS1 mRNA
CTD
PMID:24814887
NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440
G
Thbs2
thrombospondin 2
affects expression
ISO
diethyl malate affects the expression of THBS2 mRNA
CTD
PMID:24814887
NCBI chr 1:55,670,394...55,699,789
Ensembl chr 1:55,670,394...55,699,789
G
Tnc
tenascin C
affects expression
ISO
diethyl malate affects the expression of TNC mRNA
CTD
PMID:24814887
NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624
G
Tnfrsf11b
TNF receptor superfamily member 11B
affects expression
ISO
diethyl malate affects the expression of TNFRSF11B mRNA
CTD
PMID:24814887
NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538
G
Tnnt1
troponin T1, slow skeletal type
affects expression
ISO
diethyl malate affects the expression of TNNT1 mRNA
CTD
PMID:24814887
NCBI chr 1:69,306,362...69,316,721
Ensembl chr 1:69,306,362...69,316,721
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Tslp
thymic stromal lymphopoietin
affects expression
ISO
diethyl malate affects the expression of TSLP mRNA
CTD
PMID:24814887
NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions increases expression
ISO
Mycophenolic Acid promotes the reaction [Esomeprazole results in increased expression of CYP1A1 mRNA]
CTD
PMID:25929522
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Ccl2
C-C motif chemokine ligand 2
multiple interactions
ISO
eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CCL2 mRNA]
CTD
PMID:21565208
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
multiple interactions increases activity
ISO
[[eupatilin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [eupatilin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam
CTD
PMID:31756459
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Il1b
interleukin 1 beta
multiple interactions
ISO
eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL1B mRNA]
CTD
PMID:21565208
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il6
interleukin 6
multiple interactions
ISO
eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 mRNA]
CTD
PMID:21565208
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Nfkbia
NFKB inhibitor alpha
multiple interactions
ISO
eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
CTD
PMID:21565208
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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Nos2
nitric oxide synthase 2
multiple interactions
ISO
eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of NOS2 mRNA]; eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of NOS2 protein]
CTD
PMID:21565208
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of PTGS2 mRNA]; eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of PTGS2 protein]
CTD
PMID:21565208
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 affects the localization of RELA protein]
CTD
PMID:21565208
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Slc2a1
solute carrier family 2 member 1
multiple interactions
ISO
eupatilin inhibits the reaction [SLC2A1 protein results in increased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose]
CTD
PMID:36870413
NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
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Tnf
tumor necrosis factor
multiple interactions
ISO
eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF mRNA]
CTD
PMID:21565208
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Adcyap1
adenylate cyclase activating polypeptide 1
multiple interactions
ISO
Famotidine inhibits the reaction [ADCYAP1 protein affects the secretion of Acids]
CTD
PMID:20388963
NCBI chr 9:113,102,632...113,122,500
Ensembl chr 9:113,103,718...113,109,773
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Agt
angiotensinogen
multiple interactions
EXP
Famotidine inhibits the reaction [Indomethacin results in increased expression of AGT protein]
CTD
PMID:27645307
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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Braf
B-Raf proto-oncogene, serine/threonine kinase
decreases activity
ISO
Famotidine results in decreased activity of BRAF protein
CTD
PMID:20823850
NCBI chr 4:68,375,484...68,510,652
Ensembl chr 4:68,384,649...68,510,463
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Car12
carbonic anhydrase 12
multiple interactions
ISO
Famotidine binds to and results in decreased activity of CA12 protein
CTD
PMID:30344913
NCBI chr 8:67,274,739...67,330,428
Ensembl chr 8:67,274,359...67,330,440
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Car2
carbonic anhydrase 2
multiple interactions
ISO
Famotidine binds to and results in decreased activity of CA2 protein
CTD
PMID:30344913
NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
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Car6
carbonic anhydrase 6
multiple interactions
ISO
Famotidine binds to and results in decreased activity of CA6 protein
CTD
PMID:30344913
NCBI chr 5:160,658,104...160,676,644
Ensembl chr 5:160,658,105...160,676,644
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Car7
carbonic anhydrase 7
multiple interactions
ISO
Famotidine binds to and results in decreased activity of CA7 protein
CTD
PMID:30344913
NCBI chr19:429,063...438,478
Ensembl chr19:429,075...438,467
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Cat
catalase
multiple interactions
EXP
Famotidine inhibits the reaction [Indomethacin results in decreased activity of CAT protein]; Famotidine inhibits the reaction [Indomethacin results in increased activity of CAT protein]; Quercetin promotes the reaction [Famotidine inhibits the reaction [Indomethacin results in decreased activity of CAT protein]]
CTD
PMID:18726076 PMID:19034656 PMID:19497431 PMID:25926722
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Cd80
Cd80 molecule
multiple interactions
ISO
Famotidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein]]
CTD
PMID:12538815
NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030
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Ctnnb1
catenin beta 1
multiple interactions increases expression
ISO
Famotidine inhibits the reaction [Dizocilpine Maleate results in decreased expression of CTNNB1 mRNA] Famotidine results in increased expression of CTNNB1 mRNA
CTD
PMID:31563592
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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Cxcl1
C-X-C motif chemokine ligand 1
increases expression
EXP
Famotidine results in increased expression of CXCL1 protein
CTD
PMID:12023551
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
multiple interactions
ISO
Famotidine inhibits the reaction [CYP2C19 gene affects the susceptibility to Lansoprazole]
CTD
PMID:15963082
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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Fgf2
fibroblast growth factor 2
multiple interactions
ISO
[Famotidine co-treated with Sucralfate] results in increased expression of FGF2 mRNA
CTD
PMID:17717918
NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
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Fgf21
fibroblast growth factor 21
increases expression
ISO
Famotidine results in increased expression of FGF21 protein
CTD
PMID:8774986
NCBI chr 1:96,083,360...96,084,911
Ensembl chr 1:96,083,441...96,090,454
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions
ISO
Famotidine inhibits the reaction [[Dimaprit binds to and results in increased activity of HRH2 protein] which results in increased expression of FOS mRNA]; Famotidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH2 protein] which results in increased expression of FOS mRNA]
CTD
PMID:9187264
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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Gabra1
gamma-aminobutyric acid type A receptor subunit alpha 1
multiple interactions
EXP
Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG1 protein]]; Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein]]
CTD
PMID:15363660
NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
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Gabra3
gamma-aminobutyric acid type A receptor subunit alpha 3
multiple interactions
EXP
Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG1 protein]]; Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG2 protein]]
CTD
PMID:15363660
NCBI chr X:150,244,745...150,501,566
Ensembl chr X:150,261,607...150,501,559
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Gabrb2
gamma-aminobutyric acid type A receptor subunit beta 2
multiple interactions
EXP
Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG1 protein]]; Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein]]; Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG1 protein]]; Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG2 protein]]
CTD
PMID:15363660
NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251
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Gabrg1
gamma-aminobutyric acid type A receptor subunit gamma 1
multiple interactions
EXP
Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG1 protein]]; Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG1 protein]]
CTD
PMID:15363660
NCBI chr14:37,396,217...37,469,606
Ensembl chr14:37,396,294...37,635,956
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Gabrg2
gamma-aminobutyric acid type A receptor subunit gamma 2
multiple interactions
EXP
Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Famotidine inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA3 protein binds to GABRB2 protein binds to GABRG2 protein]]
CTD
PMID:15363660
NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346
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Gast
gastrin
affects expression increases expression
ISO EXP
Famotidine affects the expression of GAST protein Famotidine results in increased expression of GAST protein
CTD
PMID:12503773 PMID:17652263
NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496
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Ghrl
ghrelin and obestatin prepropeptide
multiple interactions
EXP
Famotidine inhibits the reaction [GHRL protein results in increased secretion of Acids]
CTD
PMID:16838121
NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621
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Gsk3b
glycogen synthase kinase 3 beta
multiple interactions
ISO
Famotidine inhibits the reaction [Dizocilpine Maleate results in decreased phosphorylation of and results in increased activity of GSK3B protein]; Famotidine inhibits the reaction [Dizocilpine Maleate results in increased expression of GSK3B mRNA]
CTD
PMID:31563592
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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Hrh2
histamine receptor H 2
multiple interactions decreases activity increases expression
ISO EXP
[Famotidine binds to and results in decreased activity of HRH2 protein] which affects the susceptibility to Metformin; Famotidine binds to and results in decreased activity of HRH2 protein; Famotidine inhibits the reaction [[Dimaprit binds to and results in increased activity of HRH2 protein] which results in increased expression of FOS mRNA]; Famotidine inhibits the reaction [[Histamine binds to and results in increased activity of HRH2 protein] which results in increased expression of FOS mRNA] Famotidine results in decreased activity of HRH2 protein [Famotidine binds to and results in decreased activity of HRH2 protein] which affects the susceptibility to Histamine Famotidine results in increased expression of HRH2 protein
CTD
PMID:9187264 PMID:9681472 PMID:12832840 PMID:15961859 PMID:16632449 PMID:21276809 More...
NCBI chr17:10,366,004...10,407,791
Ensembl chr17:10,368,298...10,407,631
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Hspa1a
heat shock protein family A (Hsp70) member 1A
decreases expression multiple interactions
EXP
Famotidine results in decreased expression of HSPA1A protein Zinc Compounds analog inhibits the reaction [Famotidine results in decreased expression of HSPA1A protein]; Zinc Sulfate inhibits the reaction [Famotidine results in decreased expression of HSPA1A protein]
CTD
PMID:16945336
NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
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Icam1
intercellular adhesion molecule 1
multiple interactions
ISO
Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]]
CTD
PMID:11752121 PMID:12364868 PMID:12538815
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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Ifng
interferon gamma
multiple interactions
ISO
Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]] Famotidine inhibits the reaction [Dimaprit inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IFNG protein]]
CTD
PMID:11752121 PMID:12364868 PMID:19277450
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Il10
interleukin 10
multiple interactions
ISO
Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]
CTD
PMID:11752121
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il12a
interleukin 12A
multiple interactions
ISO
Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]
CTD
PMID:11752121 PMID:12364868
NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
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Il12b
interleukin 12B
multiple interactions
ISO
Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]
CTD
PMID:11752121 PMID:12364868
NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
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Il18
interleukin 18
multiple interactions
ISO
Famotidine inhibits the reaction [Cimetidine results in increased expression of IL18 protein]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]]
CTD
PMID:11752121 PMID:12364868 PMID:16723495
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
G
Il1b
interleukin 1 beta
multiple interactions
ISO EXP
[Famotidine co-treated with Sucralfate] results in decreased expression of IL1B mRNA Famotidine inhibits the reaction [Ethanol results in increased expression of IL1B protein]; Famotidine inhibits the reaction [Indomethacin results in increased expression of IL1B mRNA]
CTD
PMID:17717918 PMID:27474069 PMID:27645307
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il2
interleukin 2
multiple interactions
ISO
Famotidine inhibits the reaction [Dimaprit inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL2 protein]]
CTD
PMID:19277450
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
G
Il4
interleukin 4
multiple interactions
ISO
Famotidine inhibits the reaction [Dimaprit inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of IL4 protein]]
CTD
PMID:19277450
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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Il6
interleukin 6
multiple interactions
EXP
Famotidine inhibits the reaction [Ethanol results in increased expression of IL6 protein]; Famotidine inhibits the reaction [Ethanol results in increased secretion of IL6 protein]
CTD
PMID:17603938 PMID:27474069
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO
Famotidine inhibits the reaction [Histamine results in increased phosphorylation of MAPK1 protein]
CTD
PMID:17656145
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
Famotidine inhibits the reaction [Histamine results in increased phosphorylation of MAPK3 protein]
CTD
PMID:17656145
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Mmp1
matrix metallopeptidase 1
multiple interactions
ISO
Famotidine inhibits the reaction [Histamine results in increased expression of MMP1 mRNA]; Famotidine inhibits the reaction [Histamine results in increased secretion of MMP1 protein]
CTD
PMID:17656145
NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
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Mmp9
matrix metallopeptidase 9
multiple interactions
EXP
Famotidine inhibits the reaction [Ethanol results in increased expression of and results in increased activity of MMP9 protein]; Famotidine inhibits the reaction [Ethanol results in increased expression of MMP9 mRNA]; Famotidine inhibits the reaction [Ethanol results in increased secretion of and results in increased activity of MMP9 protein]; Famotidine inhibits the reaction [Ethanol results in increased secretion of MMP9 protein]
CTD
PMID:17603938 PMID:22257724
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Mpo
myeloperoxidase
multiple interactions increases expression
ISO EXP
Famotidine inhibits the reaction [Acids results in increased activity of MPO protein] Famotidine results in increased expression of MPO protein Famotidine inhibits the reaction [Ethanol results in increased activity of MPO protein]; Famotidine inhibits the reaction [Indomethacin results in increased activity of MPO protein]; Famotidine promotes the reaction [Chlorpheniramine results in decreased activity of MPO protein]; Quercetin promotes the reaction [Famotidine inhibits the reaction [Indomethacin results in increased activity of MPO protein]]
CTD
PMID:12023551 PMID:16091555 PMID:16437673 PMID:17603938 PMID:18726076 PMID:19034656 PMID:19497431 PMID:20723003 PMID:22257724 PMID:25926722 PMID:27474069 More...
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Nppb
natriuretic peptide B
decreases expression
EXP
Famotidine results in decreased expression of NPPB protein
CTD
PMID:30310171
NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
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Ntf3
neurotrophin 3
multiple interactions
EXP
[Pyrilamine co-treated with Famotidine co-treated with ciproxifan] inhibits the reaction [Histamine results in increased expression of NTF3 protein]; [Pyrilamine co-treated with Famotidine] inhibits the reaction [Histamine results in increased expression of NTF3 protein]; Famotidine inhibits the reaction [Histamine results in increased expression of NTF3 protein]
CTD
PMID:21276809
NCBI chr 4:158,914,984...158,984,453
Ensembl chr 4:158,914,957...158,984,596
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Pcna
proliferating cell nuclear antigen
multiple interactions
EXP
[Famotidine co-treated with Indomethacin] promotes the reaction [Acetic Acid results in increased expression of PCNA protein]; Famotidine promotes the reaction [Acetic Acid results in increased expression of PCNA protein]
CTD
PMID:18853145 PMID:19251492
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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Ppp3ca
protein phosphatase 3 catalytic subunit alpha
decreases expression
EXP
Famotidine results in decreased expression of PPP3CA protein
CTD
PMID:30310171
NCBI chr 2:225,165,981...225,440,978
Ensembl chr 2:225,165,766...225,438,974
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Prdx3
peroxiredoxin 3
increases expression
EXP
Famotidine results in increased expression of PRDX3 protein
CTD
PMID:30310171
NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111
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Prl
prolactin
increases expression
ISO
Famotidine results in increased expression of PRL protein
CTD
PMID:8104296
NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
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Ptgs1
prostaglandin-endoperoxide synthase 1
multiple interactions
EXP
Famotidine inhibits the reaction [Indomethacin results in increased expression of PTGS1 mRNA]
CTD
PMID:27645307
NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
EXP
Famotidine inhibits the reaction [Indomethacin results in increased expression of PTGS2 mRNA]
CTD
PMID:27645307
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
EXP
Famotidine inhibits the reaction [Ethanol results in increased expression of RELA protein]
CTD
PMID:27474069
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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RT1-A2
RT1 class Ia, locus A2
affects expression
ISO
Famotidine affects the expression of HLA-E mRNA
CTD
PMID:25811541
NCBI chr20:4,870,939...4,910,183
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RT1-DMb
RT1 class II, locus DMb
affects expression
ISO
Famotidine affects the expression of HLA-DMB mRNA
CTD
PMID:25811541
NCBI chr20:4,693,102...4,700,340
Ensembl chr20:4,693,103...4,700,340
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Serpine1
serpin family E member 1
multiple interactions
EXP
Heparin promotes the reaction [[Famotidine co-treated with Lipopolysaccharides] results in increased expression of SERPINE1 protein]
CTD
PMID:16401727
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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Slc19a3
solute carrier family 19 member 3
multiple interactions increases uptake
ISO
Famotidine inhibits the reaction [SLC19A3 protein results in increased uptake of Metformin]; Famotidine inhibits the reaction [SLC19A3 protein results in increased uptake of Thiamine] SLC19A3 protein results in increased uptake of Famotidine
CTD
PMID:26528626
NCBI chr 9:84,275,722...84,299,368
Ensembl chr 9:84,277,024...84,299,337
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Slc22a1
solute carrier family 22 member 1
multiple interactions increases uptake affects transport
ISO EXP
Famotidine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] SLC22A1 protein results in increased uptake of Famotidine SLC22A1 protein affects the transport of Famotidine
CTD
PMID:16006492 PMID:16141367
NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
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Slc22a2
solute carrier family 22 member 2
increases uptake multiple interactions
ISO EXP
SLC22A2 protein results in increased uptake of Famotidine Famotidine inhibits the reaction [SLC22A2 protein affects the transport of Tetraethylammonium]; Famotidine inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Famotidine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:15496291 PMID:16006492 PMID:16141367 PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Slc22a3
solute carrier family 22 member 3
multiple interactions decreases activity
ISO
Famotidine inhibits the reaction [SLC22A3 protein affects the transport of 1-Methyl-4-phenylpyridinium]; Famotidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] Famotidine results in decreased activity of SLC22A3 protein
CTD
PMID:16141367
NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
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Slc22a8
solute carrier family 22 member 8
multiple interactions increases uptake
ISO EXP
estrone sulfate inhibits the reaction [SLC22A8 protein results in increased uptake of Famotidine]; Famotidine inhibits the reaction [SLC22A8 protein affects the transport of estrone sulfate]; Probenecid inhibits the reaction [SLC22A8 protein affects the transport of Famotidine] Famotidine inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]; Penicillin G inhibits the reaction [SLC22A8 protein results in increased uptake of Famotidine]; Probenecid inhibits the reaction [SLC22A8 protein affects the transport of Famotidine]; Probenecid promotes the reaction [SLC22A8 protein results in increased uptake of Famotidine] Famotidine inhibits the reaction [SLC22A8 protein results in increased uptake of p-Aminohippuric Acid]
CTD
PMID:15100168 PMID:15319347 PMID:15496291 PMID:16006492
NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
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Slc47a1
solute carrier family 47 member 1
multiple interactions
ISO
Famotidine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
CTD
PMID:22419765
NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
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Slc47a2
solute carrier family 47 member 2
multiple interactions
ISO
Famotidine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
CTD
PMID:22419765
NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904
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Tacr1
tachykinin receptor 1
multiple interactions
ISO
Famotidine inhibits the reaction [Acids affects the localization of TACR1 protein]
CTD
PMID:16091555
NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733
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Tnf
tumor necrosis factor
multiple interactions increases secretion
ISO EXP
Famotidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]]; Famotidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]] Famotidine results in increased secretion of TNF protein Famotidine inhibits the reaction [Dimaprit inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TNF protein]] Famotidine inhibits the reaction [Ethanol results in increased expression of TNF protein]; Famotidine inhibits the reaction [Ethanol results in increased secretion of TNF protein]; Famotidine inhibits the reaction [Indomethacin results in increased expression of TNF mRNA]
CTD
PMID:11752121 PMID:12538815 PMID:17603938 PMID:17698507 PMID:19277450 PMID:27474069 PMID:27645307 More...
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
multiple interactions
ISO
[hydrocortisone hemisuccinate co-treated with Dimethyl Sulfoxide] results in increased expression of CYP1A2
CTD
PMID:18347083
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
multiple interactions
ISO
[hydrocortisone hemisuccinate co-treated with Dimethyl Sulfoxide] results in increased expression of CYP3A4
CTD
PMID:18347083
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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F2
coagulation factor II, thrombin
affects expression
ISO
hydrocortisone hemisuccinate affects the expression of F2 protein
CTD
PMID:12542493
NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
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Il18
interleukin 18
decreases secretion
ISO
hydrocortisone hemisuccinate results in decreased secretion of IL18 protein
CTD
PMID:20421217
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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Il1b
interleukin 1 beta
decreases secretion
ISO
hydrocortisone hemisuccinate results in decreased secretion of IL1B protein
CTD
PMID:20421217
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il6
interleukin 6
decreases secretion
ISO
hydrocortisone hemisuccinate results in decreased secretion of IL6 protein
CTD
PMID:20421217
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Tnf
tumor necrosis factor
decreases secretion
ISO
hydrocortisone hemisuccinate results in decreased secretion of TNF protein
CTD
PMID:20421217
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Abca1
ATP binding cassette subfamily A member 1
increases expression
ISO
Lansoprazole results in increased expression of ABCA1 protein Lansoprazole results in increased expression of ABCA1 mRNA; Lansoprazole results in increased expression of ABCA1 protein
CTD
PMID:20060385
NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
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Abcb1a
ATP binding cassette subfamily B member 1A
affects response to substance
ISO
ABCB1 affects the susceptibility to Lansoprazole
CTD
PMID:19238367
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Apoe
apolipoprotein E
increases expression
ISO
Lansoprazole results in increased expression of APOE mRNA; Lansoprazole results in increased expression of APOE protein
CTD
PMID:20060385
NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
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Aqp4
aquaporin 4
increases expression
ISO
Lansoprazole results in increased expression of AQP4 mRNA; Lansoprazole results in increased expression of AQP4 protein
CTD
PMID:20437101
NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856
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Bcl2
BCL2, apoptosis regulator
multiple interactions
EXP
Lansoprazole inhibits the reaction [Diatrizoate Meglumine results in decreased expression of BCL2 mRNA]
CTD
PMID:28412091
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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C1qa
complement C1q A chain
decreases expression
EXP
Lansoprazole results in decreased expression of C1QA mRNA
CTD
PMID:25626140
NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534
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C1qc
complement C1q C chain
decreases expression
EXP
Lansoprazole results in decreased expression of C1QC mRNA
CTD
PMID:25626140
NCBI chr 5:149,127,412...149,130,757
Ensembl chr 5:149,127,415...149,131,017
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C4bpa
complement component 4 binding protein, alpha
decreases expression
EXP
Lansoprazole results in decreased expression of C4BPA mRNA
CTD
PMID:25626140
NCBI chr13:42,075,715...42,111,205
Ensembl chr13:42,075,717...42,111,205
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C4bpb
complement component 4 binding protein, beta
decreases expression
EXP
Lansoprazole results in decreased expression of C4BPB mRNA
CTD
PMID:25626140
NCBI chr13:42,120,798...42,131,515
Ensembl chr13:42,120,798...42,131,817
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Casp3
caspase 3
multiple interactions
ISO EXP
Lansoprazole inhibits the reaction [Demecolcine results in increased activity of CASP3 protein] Lansoprazole inhibits the reaction [Diatrizoate Meglumine results in increased expression of CASP3 mRNA]; Lansoprazole inhibits the reaction [Ethanol results in increased expression of CASP3 protein]
CTD
PMID:12530016 PMID:28412091 PMID:29339218
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cat
catalase
multiple interactions
EXP
Lansoprazole inhibits the reaction [Ethanol results in decreased activity of CAT protein]; Lansoprazole inhibits the reaction [Indomethacin results in increased activity of CAT protein]
CTD
PMID:18726076 PMID:29339218
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Cfi
complement factor I
decreases expression
EXP
Lansoprazole results in decreased expression of CFI mRNA
CTD
PMID:25626140
NCBI chr 2:218,389,079...218,430,565
Ensembl chr 2:218,387,990...218,430,561
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Cxcl1
C-X-C motif chemokine ligand 1
decreases expression multiple interactions
EXP
Lansoprazole results in decreased expression of CXCL1 mRNA; Lansoprazole results in decreased expression of CXCL1 protein Lansoprazole inhibits the reaction [Indomethacin results in increased expression of CXCL1 mRNA]; Lansoprazole inhibits the reaction [Indomethacin results in increased expression of CXCL1 protein]
CTD
PMID:15334676 PMID:16328016
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases activity decreases activity increases expression
ISO EXP
Lansoprazole results in increased activity of CYP1A1 promoter Lansoprazole results in decreased activity of CYP1A1 protein Lansoprazole results in increased expression of CYP1A1 mRNA; Lansoprazole results in increased expression of CYP1A1 protein
CTD
PMID:8169844 PMID:8647108 PMID:8900397 PMID:9041675 PMID:9152597 PMID:9860486 PMID:10859152 PMID:12623754 PMID:14550749 PMID:18502397 PMID:25626140 PMID:33814510 More...
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
increases expression
ISO EXP
Lansoprazole results in increased expression of CYP1A2 mRNA; Lansoprazole results in increased expression of CYP1A2 protein
CTD
PMID:8169844 PMID:9152597 PMID:9744552 PMID:12623754 PMID:14550749 PMID:25626140 More...
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
increases expression decreases activity
ISO
Lansoprazole results in increased expression of CYP1B1 mRNA Lansoprazole results in decreased activity of CYP1B1 protein
CTD
PMID:12623754 PMID:33814510
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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Cyp2b1
cytochrome P450, family 2, subfamily b, polypeptide 1
increases expression
EXP
Lansoprazole results in increased expression of CYP2B1 protein
CTD
PMID:9152597
NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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Cyp2b2
cytochrome P450, family 2, subfamily b, polypeptide 2
increases expression
EXP
Lansoprazole results in increased expression of CYP2B2 protein
CTD
PMID:9152597
NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
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Cyp2c11
cytochrome P450, subfamily 2, polypeptide 11
increases hydroxylation multiple interactions
ISO
CYP2C9 protein results in increased hydroxylation of Lansoprazole CYP2C18 protein results in increased hydroxylation of Lansoprazole Lansoprazole inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Diclofenac]
CTD
PMID:7870052 PMID:8627562 PMID:12975331 PMID:15258107
NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
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Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
affects response to substance increases expression decreases activity increases hydroxylation affects metabolic processing increases metabolic processing decreases metabolic processing multiple interactions
ISO EXP
CYP2C19 gene affects the susceptibility to Lansoprazole; CYP2C19 gene polymorphism affects the susceptibility to Lansoprazole Lansoprazole results in increased expression of CYP2C6V1 mRNA; Lansoprazole results in increased expression of CYP2C6V1 protein Lansoprazole results in decreased activity of CYP2C19 protein CYP2C19 protein results in increased hydroxylation of Lansoprazole CYP2C19 protein affects the metabolism of Lansoprazole CYP2C19 protein results in increased metabolism of Lansoprazole; Lansoprazole results in increased metabolism of CYP2C19 protein CYP2C19 gene polymorphism results in decreased metabolism of Lansoprazole CYP2C19 affects the reaction [Lansoprazole affects the susceptibility to Tacrolimus]; CYP2C19 affects the susceptibility to [Tacrolimus co-treated with Lansoprazole]; CYP2C19 gene mutant form affects the susceptibility to [Lansoprazole co-treated with Tacrolimus]; Famotidine inhibits the reaction [CYP2C19 gene affects the susceptibility to Lansoprazole]; Lansoprazole inhibits the reaction [CYP2C19 protein results in increased hydroxylation of Mephenytoin]
CTD
PMID:8627562 PMID:8930576 PMID:9152597 PMID:9272410 PMID:11829200 PMID:11929404 PMID:12975331 PMID:14550749 PMID:15010519 PMID:15258107 PMID:15285851 PMID:15963082 PMID:17377957 PMID:19814645 PMID:21212520 PMID:21795468 More...
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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Cyp2c79
cytochrome P450, family 2, subfamily c, polypeptide 79
affects metabolic processing increases hydroxylation
ISO
CYP2C8 protein affects the metabolism of Lansoprazole CYP2C8 protein results in increased hydroxylation of Lansoprazole
CTD
PMID:7870052 PMID:8627562
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
decreases degradation multiple interactions
ISO
Lansoprazole results in decreased degradation of CYP2E1 protein Lansoprazole results in increased expression of and results in increased activity of CYP2E1 protein
CTD
PMID:36243147
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases metabolic processing increases hydroxylation increases expression affects metabolic processing
ISO
CYP3A4 protein results in increased metabolism of Lansoprazole CYP3A4 protein results in increased hydroxylation of Lansoprazole Lansoprazole results in increased expression of CYP3A4 mRNA; Lansoprazole results in increased expression of CYP3A4 protein CYP3A4 protein affects the metabolism of Lansoprazole
CTD
PMID:7870052 PMID:8627562 PMID:8930576 PMID:9744552 PMID:10859152 PMID:11829200 PMID:12975331 PMID:15010519 More...
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Cyp3a9
cytochrome P450, family 3, subfamily a, polypeptide 9
multiple interactions
ISO
CYP3A5 affects the susceptibility to [Tacrolimus co-treated with Lansoprazole]
CTD
PMID:17377957
NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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Cyp4a1
cytochrome P450, family 4, subfamily a, polypeptide 1
increases expression
EXP
Lansoprazole results in increased expression of CYP4A1 protein
CTD
PMID:9152597
NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464
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Egfr
epidermal growth factor receptor
increases expression
ISO
Lansoprazole results in increased expression of EGFR protein
CTD
PMID:9881512
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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Fas
Fas cell surface death receptor
multiple interactions
EXP
Lansoprazole inhibits the reaction [Ethanol results in increased expression of FAS protein]
CTD
PMID:29339218
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Faslg
Fas ligand
multiple interactions
EXP
Lansoprazole inhibits the reaction [Ethanol results in increased expression of FASLG protein]
CTD
PMID:29339218
NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
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Fgf2
fibroblast growth factor 2
decreases expression
ISO
Lansoprazole results in decreased expression of FGF2 protein
CTD
PMID:9881512
NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
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Fgf21
fibroblast growth factor 21
increases expression
ISO
Lansoprazole results in increased expression of FGF21 protein
CTD
PMID:8774986
NCBI chr 1:96,083,360...96,084,911
Ensembl chr 1:96,083,441...96,090,454
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Gast
gastrin
increases expression
ISO EXP
Lansoprazole results in increased expression of GAST protein
CTD
PMID:7750667 PMID:8792694 PMID:11680587 PMID:11975934 PMID:12189558 PMID:12438555 PMID:20095383 More...
NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496
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Gstp1
glutathione S-transferase pi 1
multiple interactions
ISO
Lansoprazole inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate]
CTD
PMID:23769903
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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Hamp
hepcidin antimicrobial peptide
increases expression
ISO
Lansoprazole results in increased expression of HAMP mRNA
CTD
PMID:31669099
NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
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Hmox1
heme oxygenase 1
multiple interactions increases expression increases activity
ISO EXP
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lansoprazole results in increased expression of HMOX1 mRNA]; Lansoprazole results in increased activity of and results in increased expression of HMOX1 protein Lansoprazole inhibits the reaction [Diatrizoate Meglumine results in increased expression of HMOX1 mRNA]; NFE2L2 mRNA affects the reaction [Lansoprazole results in increased expression of HMOX1 mRNA]; NFE2L2 mRNA affects the reaction [Lansoprazole results in increased expression of HMOX1 protein]; U 0126 inhibits the reaction [Lansoprazole results in increased expression of HMOX1 protein] Lansoprazole results in increased expression of HMOX1 mRNA; Lansoprazole results in increased expression of HMOX1 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lansoprazole results in increased activity of HMOX1 promoter]
CTD
PMID:16712795 PMID:19628634 PMID:19764090 PMID:28412091
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Ifng
interferon gamma
multiple interactions decreases expression
ISO
Lansoprazole inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein] Lansoprazole results in decreased expression of IFNG mRNA
CTD
PMID:16932910 PMID:19232345
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Il10
interleukin 10
multiple interactions
EXP
Lansoprazole inhibits the reaction [Ethanol results in decreased expression of IL10 protein]
CTD
PMID:29339218
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il1b
interleukin 1 beta
decreases expression multiple interactions
ISO EXP
Lansoprazole results in decreased expression of IL1B mRNA Lansoprazole inhibits the reaction [Ethanol results in increased expression of IL1B protein]
CTD
PMID:16932910 PMID:29339218
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il6
interleukin 6
decreases expression multiple interactions
ISO EXP
Lansoprazole results in decreased expression of IL6 mRNA Lansoprazole inhibits the reaction [Diatrizoate Meglumine results in increased expression of IL6 mRNA]
CTD
PMID:16932910 PMID:28412091
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Keap1
Kelch-like ECH-associated protein 1
increases oxidation
EXP
Lansoprazole results in increased oxidation of KEAP1 protein
CTD
PMID:19628634
NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
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Lhb
luteinizing hormone subunit beta
multiple interactions increases expression
EXP
Lansoprazole inhibits the reaction [LHB protein results in increased abundance of Testosterone] Lansoprazole results in increased expression of LHB protein
CTD
PMID:7589908
NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
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Mapk1
mitogen activated protein kinase 1
increases phosphorylation
EXP
Lansoprazole results in increased phosphorylation of MAPK1 protein
CTD
PMID:19628634
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
increases phosphorylation
EXP
Lansoprazole results in increased phosphorylation of MAPK3 protein
CTD
PMID:19628634
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Mapt
microtubule-associated protein tau
affects binding
ISO
Lansoprazole binds to MAPT protein alternative form
CTD
PMID:20110603
NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
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Mpo
myeloperoxidase
multiple interactions
EXP
Lansoprazole inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MPO protein]; Lansoprazole inhibits the reaction [Indomethacin results in increased activity of MPO protein]
CTD
PMID:17151854 PMID:17895592 PMID:18726076 PMID:24337826
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Nfe2l2
NFE2 like bZIP transcription factor 2
multiple interactions increases expression increases phosphorylation
EXP
Lansoprazole inhibits the reaction [Diatrizoate Meglumine results in increased expression of NFE2L2 mRNA]; NFE2L2 mRNA affects the reaction [Lansoprazole results in increased expression of HMOX1 mRNA]; NFE2L2 mRNA affects the reaction [Lansoprazole results in increased expression of HMOX1 protein] Lansoprazole results in increased expression of NFE2L2 mRNA Lansoprazole results in increased phosphorylation of NFE2L2 protein
CTD
PMID:19628634 PMID:28412091
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nfkbia
NFKB inhibitor alpha
multiple interactions
EXP
Lansoprazole inhibits the reaction [Ethanol results in decreased expression of and results in increased phosphorylation of NFKBIA protein]
CTD
PMID:29339218
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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Nr1h2
nuclear receptor subfamily 1, group H, member 2
increases activity
ISO
Lansoprazole results in increased activity of NR1H2 protein
CTD
PMID:20060385
NCBI chr 1:95,041,967...95,047,358
Ensembl chr 1:95,041,967...95,047,377
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Nr1h3
nuclear receptor subfamily 1, group H, member 3
increases activity
ISO
Lansoprazole results in increased activity of NR1H3 protein
CTD
PMID:20060385
NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
increases activity
ISO
Lansoprazole results in increased activity of NR1I2 protein
CTD
PMID:25455453
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Phospho1
phosphoethanolamine/phosphocholine phosphatase 1
decreases activity
ISO
Lansoprazole results in decreased activity of PHOSPHO1 protein
CTD
PMID:17227223
NCBI chr10:80,762,062...80,769,596
Ensembl chr10:80,760,792...80,770,342
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Pomc
proopiomelanocortin
increases expression
ISO
Lansoprazole results in increased expression of POMC protein
CTD
PMID:16524691
NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions increases expression
EXP
AG-041R inhibits the reaction [Lansoprazole results in increased expression of PTGS2 protein]
CTD
PMID:12438555
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
EXP
Lansoprazole inhibits the reaction [Ethanol results in decreased expression of and results in increased phosphorylation of RELA protein]
CTD
PMID:29339218
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Retsat
retinol saturase
decreases expression
EXP
Lansoprazole results in decreased expression of RETSAT mRNA
CTD
PMID:25626140
NCBI chr 4:104,653,306...104,662,069
Ensembl chr 4:104,653,155...104,668,310
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Serping1
serpin family G member 1
decreases expression
EXP
Lansoprazole results in decreased expression of SERPING1 mRNA
CTD
PMID:25626140
NCBI chr 3:69,842,726...69,852,583
Ensembl chr 3:69,842,739...69,852,034
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Shh
sonic hedgehog signaling molecule
decreases expression
ISO
Lansoprazole results in decreased expression of SHH mRNA
CTD
PMID:20437101
NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170
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Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Lansoprazole inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Slc22a8
solute carrier family 22 member 8
multiple interactions
ISO
[Lansoprazole results in decreased activity of SLC22A8 protein] which results in decreased uptake of Indican
CTD
PMID:36243147
NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
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Tgfa
transforming growth factor alpha
increases expression
ISO
Lansoprazole results in increased expression of TGFA protein
CTD
PMID:9881512
NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894
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Tgfb1
transforming growth factor, beta 1
increases expression
ISO
Lansoprazole results in increased expression of TGFB1 protein
CTD
PMID:36243147
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Tnf
tumor necrosis factor
multiple interactions decreases expression
ISO EXP
Lansoprazole inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein] Lansoprazole inhibits the reaction [Ethanol results in increased expression of TNF protein] Lansoprazole results in decreased expression of TNF mRNA
CTD
PMID:16932910 PMID:19232345 PMID:29339218
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tp53
tumor protein p53
multiple interactions
EXP
Lansoprazole inhibits the reaction [Diatrizoate Meglumine results in increased expression of TP53 mRNA]
CTD
PMID:28412091
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Ugt1a1
UDP glucuronosyltransferase family 1 member A1
increases expression
EXP
Lansoprazole results in increased expression of UGT1A1 mRNA
CTD
PMID:25626140
NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Ugt2b1
UDP glucuronosyltransferase 2 family, polypeptide B1
increases expression
EXP
Lansoprazole results in increased expression of UGT2B1 mRNA
CTD
PMID:25626140
NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
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Acbd5
acyl-CoA binding domain containing 5
increases expression
ISO
Malathion results in increased expression of ACBD5 mRNA
CTD
PMID:37047231
NCBI chr17:85,206,178...85,248,909
Ensembl chr17:85,206,303...85,248,215
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Ache
acetylcholinesterase
multiple interactions decreases activity
ISO EXP
[Malathion co-treated with Dichlorvos] results in decreased activity of ACHE protein; Obidoxime Chloride inhibits the reaction [Malathion results in decreased activity of ACHE protein]; Oximes analog inhibits the reaction [Malathion results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Malathion results in decreased activity of ACHE protein] [Endosulfan co-treated with Malathion] results in decreased activity of ACHE protein; [Malathion co-treated with Permethrin] results in decreased activity of ACHE protein; [Malathion co-treated with Permethrin] results in increased activity of ACHE protein; Taurine inhibits the reaction [Malathion results in decreased activity of ACHE protein]; zinc chloride inhibits the reaction [Malathion results in decreased activity of ACHE protein]
CTD
PMID:2380476 PMID:4859365 PMID:14713564 PMID:18617161 PMID:19429256 PMID:19784758 PMID:21628957 PMID:21723318 PMID:21983245 PMID:23774768 PMID:28987951 PMID:30625376 More...
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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Acot6
acyl-CoA thioesterase 6
decreases expression
ISO
Malathion results in decreased expression of ACOT6 mRNA
CTD
PMID:37047231
NCBI chr 6:103,732,372...103,741,446
Ensembl chr 6:103,732,372...103,741,446
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Acsm1
acyl-CoA synthetase medium-chain family member 1
decreases expression
ISO
Malathion results in decreased expression of ACSM1 mRNA
CTD
PMID:17311802
NCBI chr 1:173,985,715...174,020,565
Ensembl chr 1:173,984,672...174,025,495
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Adam11
ADAM metallopeptidase domain 11
increases methylation
ISO
Malathion results in increased methylation of ADAM11 promoter
CTD
PMID:37047231
NCBI chr10:87,724,115...87,742,773
Ensembl chr10:87,724,234...87,741,562
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Adam32
ADAM metallopeptidase domain 32
decreases expression
ISO
Malathion results in decreased expression of ADAM32 mRNA
CTD
PMID:37047231
NCBI chr16:67,102,384...67,212,163
Ensembl chr16:67,102,320...67,212,161
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Adamts12
ADAM metallopeptidase with thrombospondin type 1 motif, 12
decreases expression
ISO
Malathion results in decreased expression of ADAMTS12 mRNA
CTD
PMID:37047231
NCBI chr 2:60,032,873...60,327,629
Ensembl chr 2:60,032,873...60,327,629
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Adamts20
ADAM metallopeptidase with thrombospondin type 1 motif, 20
decreases expression
ISO
Malathion results in decreased expression of ADAMTS20 mRNA
CTD
PMID:37047231
NCBI chr 7:125,396,227...125,528,020
Ensembl chr 7:125,397,734...125,527,777
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Adamts6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
increases expression
ISO
Malathion results in increased expression of ADAMTS6 mRNA
CTD
PMID:37047231
NCBI chr 2:35,421,483...35,633,305
Ensembl chr 2:35,421,510...35,633,298
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Add3
adducin 3
increases expression
EXP
Malathion results in increased expression of ADD3 mRNA
CTD
PMID:19784758
NCBI chr 1:252,147,341...252,255,126
Ensembl chr 1:252,147,386...252,255,124
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Adm
adrenomedullin
increases expression
ISO
Malathion results in increased expression of ADM mRNA
CTD
PMID:37047231
NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654
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Adra2a
adrenoceptor alpha 2A
increases expression
ISO
Malathion results in increased expression of ADRA2A mRNA
CTD
PMID:37047231
NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365
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Aff1
ALF transcription elongation factor 1
increases expression
ISO
Malathion results in increased expression of AFF1 mRNA mutant form
CTD
PMID:28624474
NCBI chr14:5,861,188...6,024,196
Ensembl chr14:5,863,961...6,024,729
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Ahr
aryl hydrocarbon receptor
multiple interactions
ISO
[prothioconazole co-treated with terbutylazine co-treated with bitertanol co-treated with cypermethrin co-treated with Malathion] results in increased activity of AHR protein
CTD
PMID:25684042
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Akr1c1
aldo-keto reductase family 1, member C1
increases expression
ISO
Malathion results in increased expression of AKR1C1 mRNA
CTD
PMID:16079077 PMID:18214805
NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
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Akr1c2
aldo-keto reductase family 1, member C2
increases expression
ISO
Malathion results in increased expression of AKR1C2 mRNA
CTD
PMID:16079077
NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
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Akr1e2
aldo-keto reductase family 1, member E2
decreases expression
ISO
Malathion results in decreased expression of AKR1E2 mRNA
CTD
PMID:37047231
NCBI chr17:65,735,909...65,750,441
Ensembl chr17:65,735,943...65,750,441
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Alkal2
ALK and LTK ligand 2
increases expression
ISO
Malathion results in increased expression of ALKAL2 mRNA
CTD
PMID:37047231
NCBI chr 6:47,495,645...47,505,235
Ensembl chr 6:47,495,782...47,505,234
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Amot
angiomotin
decreases expression
ISO
Malathion results in decreased expression of AMOT mRNA
CTD
PMID:37047231
NCBI chr X:108,982,399...109,041,265
Ensembl chr X:108,984,022...109,041,272
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Angptl2
angiopoietin-like 2
decreases expression
ISO
Malathion results in decreased expression of ANGPTL2 mRNA
CTD
PMID:37047231
NCBI chr 3:16,517,185...16,547,024
Ensembl chr 3:16,517,420...16,548,178
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Angptl4
angiopoietin-like 4
decreases methylation increases expression
ISO
Malathion results in decreased methylation of ANGPTL4 promoter Malathion results in increased expression of ANGPTL4 mRNA
CTD
PMID:37047231
NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519
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Ank1
ankyrin 1
decreases expression
ISO
Malathion results in decreased expression of ANK1 mRNA
CTD
PMID:37047231
NCBI chr16:68,876,294...69,054,963
Ensembl chr16:68,877,504...69,054,759
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Ankrd55
ankyrin repeat domain 55
increases expression
ISO
Malathion results in increased expression of ANKRD55 mRNA
CTD
PMID:37047231
NCBI chr 2:43,883,877...43,983,820
Ensembl chr 2:43,883,857...43,983,680
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Aplf
aprataxin and PNKP like factor
decreases expression
ISO
Malathion results in decreased expression of APLF mRNA
CTD
PMID:37047231
NCBI chr 4:120,070,471...120,122,656
Ensembl chr 4:120,070,471...120,122,633
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Aqp12a
aquaporin 12A
decreases expression
ISO
Malathion results in decreased expression of AQP12A mRNA
CTD
PMID:37047231
NCBI chr 9:93,554,527...93,560,011
Ensembl chr 9:93,554,527...93,560,011
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Aqp9
aquaporin 9
increases expression
ISO
Malathion results in increased expression of AQP9 mRNA
CTD
PMID:37047231
NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395
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Ar
androgen receptor
multiple interactions decreases expression
ISO EXP
[terbutylazine co-treated with bitertanol co-treated with propiconazole co-treated with cypermethrin co-treated with Malathion] inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; [terbutylazine co-treated with bitertanol co-treated with propiconazole co-treated with cypermethrin co-treated with Malathion] results in decreased activity of AR protein Malathion results in decreased expression of AR mRNA
CTD
PMID:23871939 PMID:36336997
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Armc3
armadillo repeat containing 3
decreases expression
ISO
Malathion results in decreased expression of ARMC3 mRNA
CTD
PMID:37047231
NCBI chr17:81,814,087...81,917,534
Ensembl chr17:81,832,518...81,917,531
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Arnt2
aryl hydrocarbon receptor nuclear translocator 2
decreases expression
ISO
Malathion results in decreased expression of ARNT2 mRNA
CTD
PMID:37047231
NCBI chr 1:138,236,235...138,392,868
Ensembl chr 1:138,189,940...138,393,153
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Asic5
acid sensing ion channel subunit family member 5
increases expression
ISO
Malathion results in increased expression of ASIC5 mRNA
CTD
PMID:37047231
NCBI chr 2:167,307,984...167,336,812
Ensembl chr 2:167,307,984...167,336,812
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Atp2b3
ATPase plasma membrane Ca2+ transporting 3
decreases expression
ISO
Malathion results in decreased expression of ATP2B3 mRNA
CTD
PMID:37047231
NCBI chr X:151,216,483...151,289,069
Ensembl chr X:151,216,507...151,286,775
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B4galt1
beta-1,4-galactosyltransferase 1
decreases expression
ISO
Malathion results in decreased expression of B4GALT1 mRNA
CTD
PMID:32069766
NCBI chr 5:55,935,614...55,982,461
Ensembl chr 5:55,935,615...55,982,461
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B9d1
B9 domain containing 1
decreases expression
ISO
Malathion results in decreased expression of B9D1 mRNA
CTD
PMID:37047231
NCBI chr10:46,186,222...46,196,309
Ensembl chr10:46,186,691...46,196,008
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Bax
BCL2 associated X, apoptosis regulator
decreases expression increases expression multiple interactions
EXP ISO
Malathion results in decreased expression of BAX mRNA Malathion results in increased expression of BAX protein crocin inhibits the reaction [Malathion results in increased expression of BAX protein] Plant Extracts inhibits the reaction [Malathion results in increased expression of BAX protein]; Polyphenols inhibits the reaction [Malathion results in increased expression of BAX protein] Acetylcysteine inhibits the reaction [Malathion results in increased expression of BAX protein]
CTD
PMID:23774768 PMID:30769050 PMID:32120800 PMID:35274200
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bche
butyrylcholinesterase
multiple interactions increases activity decreases activity
ISO EXP
Obidoxime Chloride inhibits the reaction [Malathion results in decreased activity of BCHE protein] Malathion results in increased activity of BCHE protein
CTD
PMID:17364237 PMID:18617161 PMID:21983245 PMID:25180440
NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
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Bcl2
BCL2, apoptosis regulator
decreases expression increases expression multiple interactions
EXP ISO
Malathion results in decreased expression of BCL2 mRNA Malathion results in increased expression of BCL2 mRNA Malathion results in increased expression of BCL2 protein Acetylcysteine inhibits the reaction [Malathion results in decreased expression of BCL2 protein]
CTD
PMID:23774768 PMID:30673264 PMID:30769050 PMID:32120800
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bdnf
brain-derived neurotrophic factor
decreases secretion increases methylation
ISO
Malathion results in decreased secretion of BDNF protein Malathion results in increased methylation of BDNF protein
CTD
PMID:35292247
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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Bmi1
BMI1 proto-oncogene, polycomb ring finger
increases expression
ISO
Malathion results in increased expression of BMI1 mRNA
CTD
PMID:32069766
NCBI chr17:81,332,175...81,341,625
Ensembl chr17:81,332,214...81,388,690
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Brd7
bromodomain containing 7
increases expression
ISO
Malathion results in increased expression of BRD7 mRNA
CTD
PMID:18214912
NCBI chr19:18,708,792...18,737,497
Ensembl chr19:18,709,022...18,737,494
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Bsnd
barttin CLCNK type accessory subunit beta
increases expression
ISO
Malathion results in increased expression of BSND mRNA
CTD
PMID:37047231
NCBI chr 5:121,251,774...121,260,571
Ensembl chr 5:121,251,774...121,260,571
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Btg1
BTG anti-proliferation factor 1
decreases expression
ISO
Malathion results in decreased expression of BTG1 mRNA
CTD
PMID:32069766
NCBI chr 7:31,341,391...31,343,649
Ensembl chr 7:31,341,027...31,343,649
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Bub1
BUB1 mitotic checkpoint serine/threonine kinase
decreases expression
ISO
Malathion results in decreased expression of BUB1 mRNA
CTD
PMID:16079077
NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650
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C16h10orf53
similar to human chromosome 10 open reading frame 53
decreases expression
ISO
Malathion results in decreased expression of C10ORF53 mRNA
CTD
PMID:37047231
NCBI chr16:7,634,207...7,644,876
Ensembl chr16:7,634,207...7,644,876
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C1ql2
complement C1q like 2
decreases expression
ISO
Malathion results in decreased expression of C1QL2 mRNA
CTD
PMID:37047231
NCBI chr13:31,471,150...31,472,685
Ensembl chr13:31,471,150...31,472,689
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C2h3orf80
similar to human chromosome 3 open reading frame 80
decreases expression
ISO
Malathion results in decreased expression of C3ORF80 mRNA
CTD
PMID:37047231
NCBI chr 2:153,125,312...153,128,124
Ensembl chr 2:153,125,676...153,126,419
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C3h11orf96
similar to human chromosome 11 open reading frame 96
increases expression
ISO
Malathion results in increased expression of C11ORF96 mRNA
CTD
PMID:37047231
NCBI chr 3:79,920,125...79,921,368
Ensembl chr 3:79,920,129...79,921,523
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C3h15orf48
similar to human chromosome 15 open reading frame 48
increases expression
ISO
Malathion results in increased expression of C15ORF48 mRNA
CTD
PMID:37047231
NCBI chr 3:109,719,952...109,723,505
Ensembl chr 3:109,719,897...109,724,006 Ensembl chr 3:109,719,897...109,724,006
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C5h8orf34
similar to human chromosome 8 open reading frame 34
decreases expression
ISO
Malathion results in decreased expression of C8ORF34 mRNA
CTD
PMID:37047231
NCBI chr 5:7,237,968...7,777,119
Ensembl chr 5:7,238,853...7,776,769
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C7h12orf54
similar to human chromosome 12 open reading frame 54
decreases expression
ISO
Malathion results in decreased expression of C12ORF54 mRNA
CTD
PMID:37047231
NCBI chr 7:129,529,811...129,548,676
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Cabp7
calcium binding protein 7
decreases expression
ISO
Malathion results in decreased expression of CABP7 mRNA
CTD
PMID:37047231
NCBI chr14:79,598,822...79,609,172
Ensembl chr14:79,598,827...79,609,240
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Cacna1c
calcium voltage-gated channel subunit alpha1 C
increases expression
ISO
Malathion results in increased expression of CACNA1C mRNA
CTD
PMID:37047231
NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648
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Camk2a
calcium/calmodulin-dependent protein kinase II alpha
multiple interactions
EXP
Malathion promotes the reaction [NGF protein results in increased expression of CAMK2A mRNA]
CTD
PMID:28385489
NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
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Camk2b
calcium/calmodulin-dependent protein kinase II beta
multiple interactions
EXP
Malathion promotes the reaction [NGF protein results in increased expression of CAMK2B mRNA]
CTD
PMID:28385489
NCBI chr14:80,845,206...80,934,172
Ensembl chr14:80,845,238...80,933,994
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Capn8
calpain 8
decreases expression
ISO
Malathion results in decreased expression of CAPN8 mRNA
CTD
PMID:37047231
NCBI chr13:94,252,218...94,316,146
Ensembl chr13:94,253,054...94,316,146
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Cartpt
CART prepropeptide
increases expression
ISO
Malathion results in increased expression of CARTPT mRNA
CTD
PMID:37047231
NCBI chr 2:31,255,098...31,257,452
Ensembl chr 2:31,255,098...31,290,713
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Casp3
caspase 3
increases activity increases cleavage multiple interactions increases expression
ISO EXP
Malathion results in increased activity of CASP3 protein Malathion results in increased cleavage of CASP3 protein Malathion results in increased activity of and results in increased cleavage of CASP3 protein; Metoclopramide inhibits the reaction [Malathion results in increased activity of and results in increased cleavage of CASP3 protein] Acetylcysteine inhibits the reaction [Malathion results in increased cleavage of CASP3 protein] Malathion results in increased expression of CASP3 mRNA [Vitamin E co-treated with Selenium] inhibits the reaction [Malathion results in increased expression of CASP3 mRNA]; crocin inhibits the reaction [Malathion results in increased cleavage of CASP3 protein]; Levodopa inhibits the reaction [Malathion results in increased cleavage of CASP3 protein]
CTD
PMID:12505448 PMID:19815060 PMID:21628957 PMID:27941166 PMID:29027213 PMID:30769050 PMID:35274200 More...
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp4
caspase 4
decreases expression
ISO
Malathion results in decreased expression of CASP4 mRNA
CTD
PMID:32069766
NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
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Casp8
caspase 8
increases activity
ISO
Malathion results in increased activity of CASP8 protein
CTD
PMID:12505448
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Casp9
caspase 9
increases activity increases cleavage multiple interactions increases expression
ISO EXP
Malathion results in increased activity of CASP9 protein Malathion results in increased cleavage of CASP9 protein Acetylcysteine inhibits the reaction [Malathion results in increased cleavage of CASP9 protein] [Vitamin E co-treated with Selenium] inhibits the reaction [Malathion results in increased expression of CASP9 mRNA]; crocin inhibits the reaction [Malathion results in increased cleavage of CASP9 protein]; Levodopa inhibits the reaction [Malathion results in increased cleavage of CASP9 protein]
CTD
PMID:12505448 PMID:21628957 PMID:27941166 PMID:30769050 PMID:35274200
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cat
catalase
multiple interactions decreases expression decreases activity increases activity
EXP ISO
[Dimethoate co-treated with Malathion] results in increased activity of CAT protein; [Selenium co-treated with Vitamin E] inhibits the reaction [Malathion results in decreased activity of CAT protein]; Acetylcysteine inhibits the reaction [Malathion results in increased activity of CAT protein]; alpha-Tocopherol inhibits the reaction [Malathion results in increased activity of CAT protein]; Pentoxifylline inhibits the reaction [Malathion results in increased activity of CAT protein]; Taurine inhibits the reaction [Malathion results in decreased activity of CAT protein]; Vitamin E inhibits the reaction [Malathion results in increased activity of CAT protein]; zinc chloride inhibits the reaction [Malathion results in decreased activity of CAT protein] Malathion results in decreased expression of CAT protein [Ascorbic Acid co-treated with Vitamin E] inhibits the reaction [Malathion results in increased activity of CAT protein]; Acetylcysteine inhibits the reaction [Malathion results in decreased activity of CAT protein]; Ascorbic Acid inhibits the reaction [Malathion results in increased activity of CAT protein]; Vitamin E inhibits the reaction [Malathion results in increased activity of CAT protein] [Malathion co-treated with 1,4-bis(4-hydroxyiminomethylpyridinium)butane dibromide] results in increased activity of CAT protein; [Malathion co-treated with pralidoxime] results in increased activity of CAT protein; lavender oil inhibits the reaction [Malathion results in decreased expression of CAT protein]; Plant Extracts inhibits the reaction [Malathion results in decreased activity of CAT protein]; Polyphenols inhibits the reaction [Malathion results in decreased activity of CAT protein]
CTD
PMID:11834209 PMID:18655177 PMID:19429256 PMID:20194575 PMID:21628957 PMID:21723318 PMID:24810974 PMID:25180440 PMID:28987951 PMID:30409133 PMID:30673264 PMID:30769050 PMID:32120800 PMID:36336997 More...
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Cbfb
core-binding factor subunit beta
increases expression
ISO
Malathion results in increased expression of CBFB mRNA
CTD
PMID:32069766
NCBI chr19:33,049,162...33,092,752
Ensembl chr19:33,049,172...33,092,751
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Ccdc126
coiled-coil domain containing 126
increases expression
ISO
Malathion results in increased expression of CCDC126 mRNA
CTD
PMID:37047231
NCBI chr 4:78,297,625...78,318,655
Ensembl chr 4:78,297,551...78,318,655
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Cck
cholecystokinin
increases expression
EXP
Malathion results in increased expression of CCK mRNA
CTD
PMID:19784758
NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084
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Ccl1
C-C motif chemokine ligand 1
increases expression
ISO
Malathion results in increased expression of CCL1 mRNA
CTD
PMID:37047231
NCBI chr10:67,128,331...67,131,109
Ensembl chr10:67,128,331...67,131,159
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Ccl19
C-C motif chemokine ligand 19
increases expression
ISO
Malathion results in increased expression of CCL19 mRNA
CTD
PMID:37047231
NCBI chr 5:56,963,364...56,965,308
Ensembl chr 5:56,963,364...56,965,308
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Ccl20
C-C motif chemokine ligand 20
increases expression
ISO
Malathion results in increased expression of CCL20 mRNA
CTD
PMID:37047231
NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
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Ccl3
C-C motif chemokine ligand 3
increases expression
ISO
Malathion results in increased expression of CCL3 mRNA
CTD
PMID:37047231
NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
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Ccl7
C-C motif chemokine ligand 7
increases expression
ISO
Malathion results in increased expression of CCL7 mRNA
CTD
PMID:37047231
NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
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Ccm2l
CCM2 like scaffold protein
increases expression
ISO
Malathion results in increased expression of CCM2L mRNA
CTD
PMID:37047231
NCBI chr 3:141,533,470...141,549,136
Ensembl chr 3:141,533,511...141,549,140
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Ccna2
cyclin A2
decreases expression
ISO
Malathion results in decreased expression of CCNA2 protein
CTD
PMID:30769050
NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
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Ccnb1
cyclin B1
decreases expression
ISO
Malathion results in decreased expression of CCNB1 protein
CTD
PMID:30769050
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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Ccne1
cyclin E1
decreases expression
ISO
Malathion results in decreased expression of CCNE1 protein
CTD
PMID:30769050
NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
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Ccser1
coiled-coil serine-rich protein 1
increases expression
ISO
Malathion results in increased expression of CCSER1 mRNA
CTD
PMID:37047231
NCBI chr 4:90,153,873...91,391,441
Ensembl chr 4:90,292,780...91,388,786
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Cd14
CD14 molecule
decreases expression
ISO
Malathion results in decreased expression of CD14 mRNA
CTD
PMID:32069766
NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
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Cd274
CD274 molecule
increases expression
ISO
Malathion results in increased expression of CD274 mRNA
CTD
PMID:37047231
NCBI chr 1:227,116,674...227,137,379
Ensembl chr 1:227,116,649...227,134,450
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Cd36
CD36 molecule
increases expression
ISO
Malathion results in increased expression of CD36 mRNA
CTD
PMID:32069766
NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
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Cd5
Cd5 molecule
decreases expression
ISO
Malathion results in decreased expression of CD5 mRNA
CTD
PMID:32069766
NCBI chr 1:207,365,337...207,386,313
Ensembl chr 1:207,365,337...207,386,313
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Cd69
Cd69 molecule
increases expression
ISO
Malathion results in increased expression of CD69 mRNA
CTD
PMID:37047231
NCBI chr 4:162,725,446...162,733,364
Ensembl chr 4:162,725,446...162,733,542
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Cdc20
cell division cycle 20
decreases expression
ISO
Malathion results in decreased expression of CDC20 mRNA
CTD
PMID:18214805
NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512
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Cdk15
cyclin-dependent kinase 15
increases expression
ISO
Malathion results in increased expression of CDK15 mRNA
CTD
PMID:37047231
NCBI chr 9:60,710,787...60,803,638
Ensembl chr 9:60,711,715...60,802,777
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Cdk2
cyclin dependent kinase 2
decreases expression increases expression
ISO
Malathion results in decreased expression of CDK2 protein Malathion results in increased expression of CDK2 mRNA
CTD
PMID:30769050 PMID:32069766
NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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Cebpg
CCAAT/enhancer binding protein gamma
increases expression
ISO
Malathion results in increased expression of CEBPG mRNA
CTD
PMID:32069766
NCBI chr 1:87,683,060...87,692,772
Ensembl chr 1:87,684,019...87,694,569
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Cenpf
centromere protein F
decreases expression
ISO
Malathion results in decreased expression of CENPF mRNA
CTD
PMID:16079077
NCBI chr13:101,184,127...101,229,714
Ensembl chr13:101,184,127...101,229,669
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Ces1d
carboxylesterase 1D
increases expression
ISO
Malathion results in increased expression of CES1 mRNA
CTD
PMID:17311802
NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
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Cfap157
cilia and flagella associated protein 157
decreases expression
ISO
Malathion results in decreased expression of CFAP157 mRNA
CTD
PMID:37047231
NCBI chr 3:16,066,521...16,073,504
Ensembl chr 3:16,066,521...16,073,495
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Cfap91
cilia and flagella associated protein 91
decreases expression
ISO
Malathion results in decreased expression of CFAP91 mRNA
CTD
PMID:37047231
NCBI chr11:62,413,613...62,457,281
Ensembl chr11:62,413,602...62,457,293
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Cfb
complement factor B
increases expression
ISO
Malathion results in increased expression of CFB mRNA
CTD
PMID:37047231
NCBI chr20:3,970,643...3,976,510
Ensembl chr20:3,951,474...3,976,505
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Ch25h
cholesterol 25-hydroxylase
increases expression
ISO
Malathion results in increased expression of CH25H mRNA
CTD
PMID:37047231
NCBI chr 1:232,014,877...232,016,195
Ensembl chr 1:232,014,880...232,016,195
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Cldn12
claudin 12
increases expression
ISO
Malathion results in increased expression of CLDN12 mRNA
CTD
PMID:37047231
NCBI chr 4:28,522,659...28,533,647
Ensembl chr 4:28,522,678...28,533,801
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Cldn22
claudin 22
decreases expression
ISO
Malathion results in decreased expression of CLDN22 mRNA
CTD
PMID:37047231
NCBI chr16:44,422,344...44,423,370
Ensembl chr16:44,422,345...44,423,354
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Cldn5
claudin 5
multiple interactions decreases expression
EXP
[Malathion co-treated with Lead] results in decreased expression of CLDN5 protein Malathion results in decreased expression of CLDN5 protein
CTD
PMID:20970449
NCBI chr11:82,212,822...82,214,248
Ensembl chr11:82,211,475...82,214,992
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Cma1
chymase 1
decreases expression
ISO
Malathion results in decreased expression of CMA1 mRNA
CTD
PMID:37047231
NCBI chr15:29,417,451...29,420,233
Ensembl chr15:29,417,451...29,420,233
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Cntn4
contactin 4
increases expression
ISO
Malathion results in increased expression of CNTN4 mRNA
CTD
PMID:37047231
NCBI chr 4:138,624,584...139,622,499
Ensembl chr 4:139,099,152...139,621,090
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Col1a2
collagen type I alpha 2 chain
increases expression
ISO
Malathion results in increased expression of COL1A2 mRNA
CTD
PMID:32069766
NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
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Cpne9
copine family member 9
decreases expression
ISO
Malathion results in decreased expression of CPNE9 mRNA
CTD
PMID:37047231
NCBI chr 4:146,429,961...146,454,335
Ensembl chr 4:146,430,792...146,454,333
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Cpz
carboxypeptidase Z
decreases expression
ISO
Malathion results in decreased expression of CPZ mRNA
CTD
PMID:37047231
NCBI chr14:75,223,692...75,246,946
Ensembl chr14:75,223,605...75,246,945
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Crh
corticotropin releasing hormone
multiple interactions decreases expression
EXP
caffeic acid inhibits the reaction [Malathion results in decreased expression of CRH mRNA]
CTD
PMID:20233601 PMID:25404496
NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
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Crisp3
cysteine-rich secretory protein 3
decreases expression
ISO
Malathion results in decreased expression of CRISP3 mRNA
CTD
PMID:37047231
NCBI chr 9:20,432,051...20,472,663
Ensembl chr 9:20,450,908...20,472,658
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Crispld2
cysteine-rich secretory protein LCCL domain containing 2
decreases expression
EXP
Malathion results in decreased expression of CRISPLD2 mRNA
CTD
PMID:19784758
NCBI chr19:48,053,153...48,111,485
Ensembl chr19:48,053,287...48,110,465
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Csf2
colony stimulating factor 2
increases expression
EXP ISO
Malathion results in increased expression of CSF2 protein Malathion results in increased expression of CSF2 mRNA
CTD
PMID:34778934 PMID:37047231
NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
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Csf3
colony stimulating factor 3
increases expression
ISO
Malathion results in increased expression of CSF3 mRNA
CTD
PMID:37047231
NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603
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Ctsd
cathepsin D
increases expression
ISO
Malathion results in increased expression of CTSD protein
CTD
PMID:8812242
NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
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Cxcl11
C-X-C motif chemokine ligand 11
increases expression
ISO
Malathion results in increased expression of CXCL11 mRNA
CTD
PMID:37047231
NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,689,424...15,692,271
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Cybb
cytochrome b-245 beta chain
multiple interactions increases expression
ISO
Plant Extracts inhibits the reaction [Malathion results in increased expression of CYBB protein]; Polyphenols inhibits the reaction [Malathion results in increased expression of CYBB protein]
CTD
PMID:32120800
NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586
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Cyp11a1
cytochrome P450, family 11, subfamily a, polypeptide 1
decreases expression multiple interactions
ISO
Malathion results in decreased expression of CYP11A1 mRNA lavender oil inhibits the reaction [Malathion results in decreased expression of CYP11A1 mRNA]
CTD
PMID:30409133
NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
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Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
multiple interactions
EXP
[bitertanol co-treated with propiconazole co-treated with cypermethrin co-treated with Malathion co-treated with terbutylazine] results in increased expression of CYP19A1 mRNA
CTD
PMID:23954766
NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
affects metabolic processing increases expression
ISO
CYP1A2 protein affects the metabolism of Malathion Malathion results in increased expression of CYP1A2 mRNA
CTD
PMID:15557345 PMID:22310298
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp27b1
cytochrome P450, family 27, subfamily b, polypeptide 1
increases expression
ISO
Malathion results in increased expression of CYP27B1 mRNA
CTD
PMID:37047231
NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241
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Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
affects metabolic processing multiple interactions increases expression decreases activity
ISO
CYP2B6 protein affects the metabolism of Malathion Malathion promotes the reaction [isomalathion results in increased expression of CYP2B6 mRNA] Malathion results in increased expression of CYP2B6 mRNA Malathion results in decreased activity of CYP2B6 protein
CTD
PMID:15557345 PMID:22310298 PMID:24333466
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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Cyp2c11
cytochrome P450, subfamily 2, polypeptide 11
decreases activity multiple interactions
ISO
Malathion results in decreased activity of CYP2C9 protein Malathion inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Tolbutamide]
CTD
PMID:20183062 PMID:22634058
NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
multiple interactions decreases activity
ISO
Malathion inhibits the reaction [CYP2E1 protein results in increased hydroxylation of Chlorzoxazone] Malathion results in decreased activity of CYP2E1 protein
CTD
PMID:22634058
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
multiple interactions increases expression affects metabolic processing
ISO
[Malathion co-treated with isomalathion] results in increased expression of CYP3A4 mRNA Malathion results in increased expression of CYP3A4 mRNA CYP3A4 protein affects the metabolism of Malathion
CTD
PMID:15557345 PMID:17110060 PMID:22310298 PMID:24333466
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Cyp3a9
cytochrome P450, family 3, subfamily a, polypeptide 9
affects metabolic processing increases expression
ISO
CYP3A5 protein affects the metabolism of Malathion Malathion results in increased expression of CYP3A5 mRNA
CTD
PMID:17110060 PMID:37047231
NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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Cyp8b1
cytochrome P450 family 8 subfamily B member 1
multiple interactions
ISO
[Insecticides results in increased abundance of Malathion] which affects the methylation of CYP8B1 gene
CTD
PMID:34516295
NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
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Dcn
decorin
increases expression
ISO
Malathion results in increased expression of DCN mRNA
CTD
PMID:37047231
NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270
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Ddc
dopa decarboxylase
affects binding increases expression
ISO
Malathion binds to [DDC protein binds to Pyridoxal Phosphate]; Malathion binds to DDC protein Malathion results in increased expression of DDC mRNA
CTD
PMID:35151785 PMID:37047231
NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208
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Ddr1
discoidin domain receptor tyrosine kinase 1
decreases expression
ISO
Malathion results in decreased expression of DDR1 mRNA
CTD
PMID:37047231
NCBI chr20:3,042,494...3,064,442
Ensembl chr20:3,044,320...3,064,468
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Ddx11
DEAD/H-box helicase 11
increases expression
ISO
Malathion results in increased expression of DDX11 mRNA
CTD
PMID:32069766
NCBI chr 9:105,833,234...105,862,844
Ensembl chr 9:105,833,504...105,862,550
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Dio1
iodothyronine deiodinase 1
decreases expression
ISO
Malathion results in decreased expression of DIO1 mRNA
CTD
PMID:37047231
NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970
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Disc1
DISC1 scaffold protein
increases expression
ISO
Malathion results in increased expression of DISC1 mRNA
CTD
PMID:37047231
NCBI chr19:53,014,201...53,223,617
Ensembl chr19:53,014,616...53,219,778
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Dkk2
dickkopf WNT signaling pathway inhibitor 2
increases expression
ISO
Malathion results in increased expression of DKK2 mRNA
CTD
PMID:37047231
NCBI chr 2:220,568,338...220,660,225
Ensembl chr 2:220,568,338...220,660,225
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Dlg2
discs large MAGUK scaffold protein 2
increases expression
ISO
Malathion results in increased expression of DLG2 mRNA
CTD
PMID:37047231
NCBI chr 1:144,451,653...146,503,949
Ensembl chr 1:144,451,472...146,499,475
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Dnmt1
DNA methyltransferase 1
decreases expression
EXP
Malathion results in decreased expression of DNMT1 mRNA
CTD
PMID:36370973
NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
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Dnmt3a
DNA methyltransferase 3 alpha
affects expression
EXP
Malathion affects the expression of DNMT3A mRNA
CTD
PMID:36370973
NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687
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Dnmt3b
DNA methyltransferase 3 beta
affects expression
EXP
Malathion affects the expression of DNMT3B mRNA
CTD
PMID:36370973
NCBI chr 3:142,130,588...142,169,128
Ensembl chr 3:142,130,592...142,169,124
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Doc2b
double C2 domain beta
decreases expression
ISO
Malathion results in decreased expression of DOC2B mRNA
CTD
PMID:37047231
NCBI chr10:60,628,029...60,653,267
Ensembl chr10:60,628,029...60,653,267
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Dsp
desmoplakin
increases expression
ISO
Malathion results in increased expression of DSP mRNA
CTD
PMID:37047231
NCBI chr17:26,623,602...26,671,692
Ensembl chr17:26,623,588...26,671,800
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Dspp
dentin sialophosphoprotein
decreases expression
ISO
Malathion results in decreased expression of DSPP mRNA
CTD
PMID:37047231
NCBI chr14:5,565,562...5,571,669
Ensembl chr14:5,565,629...5,571,672
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Dtna
dystrobrevin, alpha
decreases expression
ISO
Malathion results in decreased expression of DTNA mRNA
CTD
PMID:37047231
NCBI chr18:14,687,193...14,944,232
Ensembl chr18:14,587,852...14,944,261
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Duox1
dual oxidase 1
multiple interactions increases expression
ISO
Plant Extracts inhibits the reaction [Malathion results in increased expression of DUOX1 protein]; Polyphenols inhibits the reaction [Malathion results in increased expression of DUOX1 protein]
CTD
PMID:32120800
NCBI chr 3:109,260,526...109,295,588
Ensembl chr 3:109,262,397...109,295,563
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Dusp1
dual specificity phosphatase 1
decreases expression
ISO
Malathion results in decreased expression of DUSP1 mRNA
CTD
PMID:32069766
NCBI chr10:16,680,478...16,683,275
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Dusp5
dual specificity phosphatase 5
increases expression
ISO
Malathion results in increased expression of DUSP5 mRNA
CTD
PMID:37047231
NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818
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Dvl1
dishevelled segment polarity protein 1
increases expression
ISO
Malathion results in increased expression of DVL1 mRNA
CTD
PMID:18204794
NCBI chr 5:166,456,989...166,468,733
Ensembl chr 5:166,456,686...166,468,664
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Ebi3
Epstein-Barr virus induced 3
increases expression
ISO
Malathion results in increased expression of EBI3 mRNA
CTD
PMID:37047231
NCBI chr 9:774,252...787,544
Ensembl chr 9:783,617...787,544
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Edn1
endothelin 1
increases expression
ISO
Malathion results in increased expression of EDN1 mRNA
CTD
PMID:37047231
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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Ednrb
endothelin receptor type B
decreases expression
ISO
Malathion results in decreased expression of EDNRB mRNA
CTD
PMID:37047231
NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115
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Efcab9
EF-hand calcium binding domain 9
increases expression
ISO
Malathion results in increased expression of EFCAB9 mRNA
CTD
PMID:37047231
NCBI chr10:17,107,123...17,112,282
Ensembl chr10:17,107,123...17,112,289
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Ehbp1
EH domain binding protein 1
increases response to substance
ISO
EHBP1 gene SNP results in increased susceptibility to Malathion
CTD
PMID:23593118
NCBI chr14:96,093,327...96,380,502
Ensembl chr14:96,093,327...96,345,332
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En1
engrailed homeobox 1
decreases expression
ISO
Malathion results in decreased expression of EN1 mRNA
CTD
PMID:37047231
NCBI chr13:31,750,892...31,756,477
Ensembl chr13:31,751,545...31,755,943
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Enkur
enkurin, TRPC channel interacting protein
increases expression
ISO
Malathion results in increased expression of ENKUR mRNA
CTD
PMID:37047231
NCBI chr17:83,690,105...83,714,756
Ensembl chr17:83,690,797...83,714,408
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Epha10
EPH receptor A10
increases expression
ISO
Malathion results in increased expression of EPHA10 mRNA
CTD
PMID:37047231
NCBI chr 5:137,139,588...137,175,637
Ensembl chr 5:137,140,735...137,174,157
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Epha4
Eph receptor A4
increases expression
ISO
Malathion results in increased expression of EPHA4 mRNA
CTD
PMID:32069766
NCBI chr 9:78,815,460...78,958,139
Ensembl chr 9:78,815,460...78,958,139
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Ephx1
epoxide hydrolase 1
decreases expression
ISO
Malathion results in decreased expression of EPHX1 mRNA
CTD
PMID:17311802
NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235
G
Epop
elongin BC and polycomb repressive complex 2 associated protein
increases expression
ISO
Malathion results in increased expression of EPOP mRNA
CTD
PMID:37047231
NCBI chr10:82,624,392...82,625,912
Ensembl chr10:82,624,392...82,625,912
G
Eps8l1
EPS8-like 1
increases expression
ISO
Malathion results in increased expression of EPS8L1 mRNA
CTD
PMID:32069766
NCBI chr 1:69,343,202...69,359,778
Ensembl chr 1:69,344,243...69,363,524
G
Erbb4
erb-b2 receptor tyrosine kinase 4
increases expression
ISO
Malathion results in increased expression of ERBB4 mRNA
CTD
PMID:37047231
NCBI chr 9:69,523,733...70,596,743
Ensembl chr 9:69,531,481...70,596,595
G
Esr1
estrogen receptor 1
decreases activity
ISO
Malathion results in decreased activity of ESR1 protein
CTD
PMID:22562034
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
G
Etv6
ETS variant transcription factor 6
increases expression
ISO
Malathion results in increased expression of ETV6 mRNA mutant form
CTD
PMID:28624474
NCBI chr 4:166,849,031...167,085,211
Ensembl chr 4:166,847,686...167,084,992
G
F3
coagulation factor III, tissue factor
increases expression
ISO
Malathion results in increased expression of F3 mRNA
CTD
PMID:37047231
NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
G
Fam124a
family with sequence similarity 124 member A
increases expression
ISO
Malathion results in increased expression of FAM124A mRNA
CTD
PMID:37047231
NCBI chr15:36,799,836...36,855,062
Ensembl chr15:36,799,877...36,853,683
G
Fam227b
family with sequence similarity 227, member B
decreases expression
ISO
Malathion results in decreased expression of FAM227B mRNA
CTD
PMID:37047231
NCBI chr 3:113,226,662...113,392,396
Ensembl chr 3:113,233,205...113,392,320
G
Fam229b
family with sequence similarity 229, member B
decreases expression
ISO
Malathion results in decreased expression of FAM229B mRNA
CTD
PMID:37047231
NCBI chr20:42,538,853...42,552,355
Ensembl chr20:42,538,868...42,552,248
G
Fgf22
fibroblast growth factor 22
decreases expression
ISO
Malathion results in decreased expression of FGF22 mRNA
CTD
PMID:37047231
NCBI chr 7:9,947,632...9,956,918
Ensembl chr 7:9,948,071...9,950,486
G
Fgf6
fibroblast growth factor 6
increases expression
ISO
Malathion results in increased expression of FGF6 mRNA
CTD
PMID:32069766
NCBI chr 4:159,854,913...159,863,447
Ensembl chr 4:159,854,913...159,863,447
G
Fgfbp1
fibroblast growth factor binding protein 1
increases expression
ISO
Malathion results in increased expression of FGFBP1 mRNA
CTD
PMID:37047231
NCBI chr14:67,103,686...67,107,492
Ensembl chr14:67,104,545...67,107,496
G
Fgfr1
Fibroblast growth factor receptor 1
increases expression
ISO
Malathion results in increased expression of FGFR1 mRNA
CTD
PMID:32069766
NCBI chr16:66,491,930...66,547,161
Ensembl chr16:66,494,042...66,547,350
G
Fgg
fibrinogen gamma chain
decreases expression
ISO
Malathion results in decreased expression of FGG mRNA
CTD
PMID:37047231
NCBI chr 2:168,354,880...168,362,325
Ensembl chr 2:168,355,013...168,362,322
G
Filip1l
filamin A interacting protein 1-like
increases expression
ISO
Malathion results in increased expression of FILIP1L mRNA
CTD
PMID:37047231
NCBI chr11:42,937,353...43,177,085
Ensembl chr11:42,940,467...43,177,415
G
Flt4
Fms related receptor tyrosine kinase 4
increases expression
ISO
Malathion results in increased expression of FLT4 mRNA
CTD
PMID:37047231
NCBI chr10:33,913,725...33,954,770
Ensembl chr10:33,913,608...33,954,770
G
Foxo1
forkhead box O1
decreases expression increases methylation multiple interactions
EXP
Malathion results in decreased expression of FOXO1 mRNA Malathion results in increased methylation of FOXO1 promoter [Malathion results in increased methylation of FOXO1 promoter] which results in decreased expression of FOXO1 mRNA
CTD
PMID:36370973
NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
G
Foxo4
forkhead box O4
increases expression
ISO
Malathion results in increased expression of FOXO4 mRNA
CTD
PMID:32069766
NCBI chr X:66,385,241...66,392,115
Ensembl chr X:66,385,558...66,392,115
G
Fshr
follicle stimulating hormone receptor
increases expression
ISO
Malathion results in increased expression of FSHR mRNA
CTD
PMID:32069766
NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785
G
G6pd
glucose-6-phosphate dehydrogenase
multiple interactions increases activity
EXP
[Malathion co-treated with Carbaryl] results in increased activity of G6PD protein; Plant Extracts inhibits the reaction [[Malathion co-treated with Carbaryl] results in increased activity of G6PD protein] Malathion results in increased activity of G6PD protein
CTD
PMID:27214522
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
G
Gad1
glutamate decarboxylase 1
affects binding
ISO
Malathion binds to [GAD1 protein binds to Pyridoxal Phosphate]; Malathion binds to GAD1 protein
CTD
PMID:35151785
NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333
G
Gad2
glutamate decarboxylase 2
affects binding
ISO
Malathion binds to [GAD2 protein binds to Pyridoxal Phosphate]; Malathion binds to GAD2 protein
CTD
PMID:35151785
NCBI chr17:84,763,630...84,826,155
Ensembl chr17:84,763,628...84,826,155
G
Galnt16
polypeptide N-acetylgalactosaminyltransferase 16
increases expression
ISO
Malathion results in increased expression of GALNT16 mRNA
CTD
PMID:37047231
NCBI chr 6:100,168,943...100,250,718
Ensembl chr 6:100,170,306...100,250,705
G
Garin2
golgi associated RAB2 interactor family member 2
decreases expression
ISO
Malathion results in decreased expression of GARIN2 mRNA
CTD
PMID:37047231
NCBI chr 6:97,489,562...97,534,729
Ensembl chr 6:97,490,368...97,534,763
G
Gas2
growth arrest-specific 2
increases expression
ISO
Malathion results in increased expression of GAS2 mRNA
CTD
PMID:37047231
NCBI chr 1:101,452,361...101,582,619
Ensembl chr 1:101,482,591...101,582,619
G
Gata4
GATA binding protein 4
decreases expression
ISO
Malathion results in decreased expression of GATA4 mRNA
CTD
PMID:37047231
NCBI chr15:37,459,601...37,531,291
Ensembl chr15:37,459,601...37,505,636
G
Gbp1
guanylate binding protein 1
increases expression
ISO
Malathion results in increased expression of GBP1 mRNA
CTD
PMID:37047231
NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,398,163...231,432,131 Ensembl chr 2:231,398,163...231,432,131
G
Gbp3
guanylate binding protein 3
increases expression
ISO
Malathion results in increased expression of GBP3 mRNA
CTD
PMID:37047231
NCBI chr 2:231,460,032...231,500,266
Ensembl chr 2:231,486,062...231,493,098
G
Gbp5
guanylate binding protein 5
increases expression
ISO
Malathion results in increased expression of GBP5 mRNA
CTD
PMID:37047231
NCBI chr 2:231,237,748...231,257,071
Ensembl chr 2:231,237,748...231,257,061
G
Gk
glycerol kinase
multiple interactions increases activity
EXP
Acetylcysteine inhibits the reaction [Malathion results in increased activity of GK protein]
CTD
PMID:25449180
NCBI chr X:50,162,089...50,238,707
Ensembl chr X:50,163,123...50,238,631
G
Gk2
glycerol kinase 2
decreases expression
EXP
Malathion results in decreased expression of GK2 mRNA
CTD
PMID:25449180
NCBI chr14:12,107,071...12,108,923
Ensembl chr14:12,107,020...12,128,473
G
Gmnc
geminin coiled-coil domain containing
increases expression
ISO
Malathion results in increased expression of GMNC mRNA
CTD
PMID:37047231
NCBI chr11:73,836,255...73,847,698
Ensembl chr11:73,814,533...73,847,328
G
Gnai1
G protein subunit alpha i1
increases expression
ISO
Malathion results in increased expression of GNAI1 mRNA
CTD
PMID:37047231
NCBI chr 4:16,814,000...16,898,119
Ensembl chr 4:16,814,001...16,896,417
G
Gnai2
G protein subunit alpha i2
decreases expression
ISO
Malathion results in decreased expression of GNAI2 mRNA
CTD
PMID:32069766
NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979
G
Got1l1
glutamic-oxaloacetic transaminase 1-like 1
increases expression
ISO
Malathion results in increased expression of GOT1L1 mRNA
CTD
PMID:37047231
NCBI chr16:64,860,308...64,873,656
Ensembl chr16:64,860,704...64,866,162
G
Gp5
glycoprotein V (platelet)
increases expression
ISO
Malathion results in increased expression of GP5 mRNA
CTD
PMID:37047231
NCBI chr11:70,443,613...70,446,705
Ensembl chr11:70,443,613...70,446,705
G
Gpr179
G protein-coupled receptor 179
decreases expression
ISO
Malathion results in decreased expression of GPR179 mRNA
CTD
PMID:37047231
NCBI chr10:82,324,568...82,340,448
Ensembl chr10:82,337,771...82,340,448
G
Gps2
G protein pathway suppressor 2
decreases expression
ISO
Malathion results in decreased expression of GPS2 mRNA
CTD
PMID:32069766
NCBI chr10:54,637,360...54,640,542
Ensembl chr10:54,637,455...54,640,650
G
Gpt
glutamic--pyruvic transaminase
increases activity
EXP
Malathion results in increased activity of GPT protein
CTD
PMID:25180440 PMID:36370973
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
G
Gramd4
GRAM domain containing 4
decreases expression
ISO
Malathion results in decreased expression of GRAMD4 mRNA
CTD
PMID:32069766
NCBI chr 7:117,150,398...117,224,056
Ensembl chr 7:117,150,374...117,224,053
G
Grk1
G protein-coupled receptor kinase 1
increases expression
ISO
Malathion results in increased expression of GRK1 mRNA
CTD
PMID:37047231
NCBI chr16:76,122,501...76,135,792
Ensembl chr16:76,123,842...76,135,792
G
Gsk3b
glycogen synthase kinase 3 beta
increases expression
EXP
Malathion results in increased expression of GSK3B mRNA
CTD
PMID:25449180
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
G
Gsr
glutathione-disulfide reductase
multiple interactions decreases activity
ISO EXP
[Hexachlorocyclohexane co-treated with Malathion] results in decreased activity of GSR protein zinc chloride inhibits the reaction [Malathion results in decreased activity of GSR protein]
CTD
PMID:16718366 PMID:19429256
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
G
Gstp1
glutathione S-transferase pi 1
decreases expression
ISO
Malathion results in decreased expression of GSTP1 mRNA
CTD
PMID:32069766
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
G
Gzmb
granzyme B
decreases expression multiple interactions
ISO
Malathion results in decreased expression of GZMB protein Plant Extracts inhibits the reaction [Malathion results in decreased expression of GZMB protein]; Polyphenols inhibits the reaction [Malathion results in decreased expression of GZMB protein]
CTD
PMID:32120800
NCBI chr15:30,343,352...30,346,814
Ensembl chr15:30,173,603...30,346,814
G
H19
H19 imprinted maternally expressed transcript
increases expression
ISO
Malathion results in increased expression of H19 mRNA
CTD
PMID:37047231
NCBI chr 1:197,730,698...197,733,374
Ensembl chr 1:197,730,698...197,733,134
G
Has1
hyaluronan synthase 1
increases expression
ISO
Malathion results in increased expression of HAS1 mRNA
CTD
PMID:37047231
NCBI chr 1:58,693,411...58,705,653
Ensembl chr 1:58,693,411...58,705,397
G
Hbegf
heparin-binding EGF-like growth factor
increases expression
ISO
Malathion results in increased expression of HBEGF mRNA
CTD
PMID:37047231
NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441
G
Hdc
histidine decarboxylase
affects binding
ISO
Malathion binds to [HDC protein binds to Pyridoxal Phosphate]; Malathion binds to HDC protein
CTD
PMID:35151785
NCBI chr 3:113,847,256...113,865,334
Ensembl chr 3:113,847,260...113,865,341
G
Hilpda
hypoxia inducible lipid droplet-associated
increases expression
ISO
Malathion results in increased expression of HILPDA mRNA
CTD
PMID:37047231
NCBI chr 4:57,871,088...57,874,048
Ensembl chr 4:57,871,110...57,874,557
G
Hmox1
heme oxygenase 1
increases expression
EXP
Malathion results in increased expression of HMOX1 protein
CTD
PMID:34778934
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
G
Hnmt
histamine N-methyltransferase
decreases expression
ISO
Malathion results in decreased expression of HNMT mRNA
CTD
PMID:37047231
NCBI chr 3:6,591,804...6,623,821
Ensembl chr 3:6,591,463...6,624,012
G
Hras
HRas proto-oncogene, GTPase
multiple interactions increases expression
ISO
[Malathion co-treated with Estrogens] results in increased expression of HRAS mRNA Malathion results in increased expression of HRAS mRNA; Malathion results in increased expression of HRAS protein
CTD
PMID:18204794 PMID:19787260
NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
G
Hsd17b3
hydroxysteroid (17-beta) dehydrogenase 3
multiple interactions decreases expression
ISO EXP
lavender oil inhibits the reaction [Malathion results in decreased expression of HSD17B3 mRNA]
CTD
PMID:30409133 PMID:36336997
NCBI chr17:1,027,229...1,058,554
Ensembl chr17:1,027,229...1,058,554
G
Hsf2bp
heat shock transcription factor 2 binding protein
increases expression
ISO
Malathion results in increased expression of HSF2BP mRNA
CTD
PMID:37047231
NCBI chr20:10,035,562...10,123,059
Ensembl chr20:10,035,562...10,121,242
G
Hspb2
heat shock protein family B (small) member 2
increases expression
ISO
Malathion results in increased expression of HSPB2 protein
CTD
PMID:19607909
NCBI chr 8:51,093,267...51,094,528
Ensembl chr 8:51,081,342...51,094,533
G
Htatip2
HIV-1 Tat interactive protein 2
decreases expression
ISO
Malathion results in decreased expression of HTATIP2 mRNA
CTD
PMID:32069766
NCBI chr 1:99,473,411...99,488,632
Ensembl chr 1:99,469,245...99,488,629
G
Htra4
HtrA serine peptidase 4
decreases expression
ISO
Malathion results in decreased expression of HTRA4 mRNA
CTD
PMID:37047231
NCBI chr16:67,001,605...67,015,074
Ensembl chr16:67,001,605...67,015,074
G
Ido1
indoleamine 2,3-dioxygenase 1
increases expression
ISO
Malathion results in increased expression of IDO1 mRNA
CTD
PMID:37047231
NCBI chr16:67,430,654...67,442,726
Ensembl chr16:67,430,578...67,442,730
G
Ifi44l
interferon-induced protein 44-like
increases expression
ISO
Malathion results in increased expression of IFI44L mRNA
CTD
PMID:37047231
NCBI chr 2:240,668,742...240,706,425
Ensembl chr 2:240,668,713...240,706,359
G
Ifnb1
interferon beta 1
multiple interactions
ISO
Malathion inhibits the reaction [Lipopolysaccharides results in increased expression of IFNB1 mRNA]
CTD
PMID:18177342
NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523
G
Ifng
interferon gamma
decreases expression multiple interactions increases expression
EXP ISO
Malathion results in decreased expression of IFNG protein Plant Extracts inhibits the reaction [Malathion results in decreased expression of IFNG protein]; Polyphenols inhibits the reaction [Malathion results in decreased expression of IFNG protein] Malathion results in increased expression of IFNG mRNA Acetylcysteine inhibits the reaction [Malathion results in increased expression of IFNG mRNA]; Taurine inhibits the reaction [Malathion results in increased expression of IFNG mRNA]
CTD
PMID:19145326 PMID:24810974 PMID:25180440 PMID:28987951 PMID:32120800
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
G
Il11
interleukin 11
increases expression
ISO
Malathion results in increased expression of IL11 mRNA
CTD
PMID:37047231
NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129
G
Il13
interleukin 13
increases expression
ISO
Malathion results in increased expression of IL13 mRNA
CTD
PMID:37047231
NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
G
Il13ra2
interleukin 13 receptor subunit alpha 2
increases expression
ISO
Malathion results in increased expression of IL13RA2 mRNA
CTD
PMID:32069766
NCBI chr X:111,002,590...111,074,053
Ensembl chr X:111,002,592...111,072,381
G
Il1a
interleukin 1 alpha
increases expression
ISO
Malathion results in increased expression of IL1A mRNA
CTD
PMID:37047231
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
G
Il1b
interleukin 1 beta
multiple interactions increases expression
EXP ISO
Acetylcysteine inhibits the reaction [Malathion results in increased expression of IL1B mRNA]; Taurine inhibits the reaction [Malathion results in increased expression of IL1B mRNA]
CTD
PMID:24810974 PMID:25180440 PMID:28987951 PMID:37047231
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il1r2
interleukin 1 receptor type 2
decreases expression
EXP
Malathion results in decreased expression of IL1R2 mRNA
CTD
PMID:19784758
NCBI chr 9:42,384,280...42,424,726
Ensembl chr 9:42,384,433...42,424,725
G
Il2
interleukin 2
multiple interactions decreases expression
ISO
Plant Extracts inhibits the reaction [Malathion results in decreased expression of IL2 protein]; Polyphenols inhibits the reaction [Malathion results in decreased expression of IL2 protein]
CTD
PMID:32120800
NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
G
Il23a
interleukin 23 subunit alpha
increases expression
ISO
Malathion results in increased expression of IL23A mRNA
CTD
PMID:37047231
NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
G
Il24
interleukin 24
increases expression
ISO
Malathion results in increased expression of IL24 mRNA
CTD
PMID:37047231
NCBI chr13:42,353,089...42,358,487
Ensembl chr13:42,353,090...42,358,487
G
Il36g
interleukin 36, gamma
increases expression
ISO
Malathion results in increased expression of IL36G mRNA
CTD
PMID:37047231
NCBI chr 3:6,948,323...6,954,485
Ensembl chr 3:6,948,297...6,954,480
G
Il4
interleukin 4
decreases expression multiple interactions
ISO
Malathion results in decreased expression of IL4 protein Plant Extracts inhibits the reaction [Malathion results in decreased expression of IL4 protein]; Polyphenols inhibits the reaction [Malathion results in decreased expression of IL4 protein]
CTD
PMID:32120800
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
G
Il6
interleukin 6
multiple interactions increases expression
EXP ISO
Acetylcysteine inhibits the reaction [Malathion results in increased expression of IL6 mRNA]
CTD
PMID:24810974 PMID:25180440 PMID:37047231
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Inhba
inhibin subunit beta A
increases expression decreases methylation
ISO
Malathion results in increased expression of INHBA mRNA Malathion results in decreased methylation of INHBA promoter
CTD
PMID:37047231
NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982
G
Ins1
insulin 1
increases expression
EXP
Malathion results in increased expression of INS1 protein
CTD
PMID:25449180
NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
G
Irak1
interleukin-1 receptor-associated kinase 1
increases expression
ISO
Malathion results in increased expression of IRAK1 mRNA
CTD
PMID:32069766
NCBI chr X:151,768,621...151,778,521
Ensembl chr X:151,768,777...151,778,521
G
Irak2
interleukin-1 receptor-associated kinase 2
increases expression
ISO
Malathion results in increased expression of IRAK2 mRNA
CTD
PMID:37047231
NCBI chr 4:146,786,004...146,842,615
Ensembl chr 4:146,786,100...146,842,602
G
Irx2
iroquois homeobox 2
increases expression
ISO
Malathion results in increased expression of IRX2 mRNA
CTD
PMID:37047231
NCBI chr 1:30,660,960...30,666,378
Ensembl chr 1:30,660,960...30,666,378
G
Itgb8
integrin subunit beta 8
decreases methylation increases expression
ISO
Malathion results in decreased methylation of ITGB8 promoter Malathion results in increased expression of ITGB8 mRNA
CTD
PMID:37047231
NCBI chr 6:140,125,002...140,208,261
Ensembl chr 6:140,127,203...140,208,476
G
Kazn
kazrin, periplakin interacting protein
decreases expression
ISO
Malathion results in decreased expression of KAZN mRNA
CTD
PMID:37047231
NCBI chr 5:154,392,793...155,381,567
Ensembl chr 5:154,392,793...154,779,074
G
Kcnh5
potassium voltage-gated channel subfamily H member 5
increases expression
ISO
Malathion results in increased expression of KCNH5 mRNA
CTD
PMID:37047231
NCBI chr 6:93,615,174...93,908,107
Ensembl chr 6:93,624,529...93,908,107
G
Kcnma1
potassium calcium-activated channel subfamily M alpha 1
increases methylation decreases expression
ISO
Malathion results in increased methylation of KCNMA1 promoter Malathion results in decreased expression of KCNMA1 mRNA
CTD
PMID:37047231
NCBI chr15:302,480...1,007,675
Ensembl chr15:302,214...1,001,198
G
Kif6
kinesin family member 6
decreases expression
ISO
Malathion results in decreased expression of KIF6 mRNA
CTD
PMID:37047231
NCBI chr 9:11,076,203...11,373,205
Ensembl chr 9:11,072,824...11,373,006
G
Kmt2a
lysine methyltransferase 2A
increases mutagenesis increases expression
ISO
Malathion results in increased mutagenesis of KMT2A gene Malathion results in increased expression of KMT2A mRNA mutant form
CTD
PMID:28624474
NCBI chr 8:45,116,763...45,193,320
Ensembl chr 8:45,118,814...45,193,181
G
Krt14
keratin 14
increases expression
ISO
Malathion results in increased expression of KRT14 mRNA
CTD
PMID:37047231
NCBI chr10:85,137,786...85,142,054
Ensembl chr10:85,066,802...85,171,799
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Krt17
keratin 17
increases expression
ISO
Malathion results in increased expression of KRT17 mRNA
CTD
PMID:37047231
NCBI chr10:85,178,673...85,183,392
Ensembl chr10:85,178,675...85,183,392
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Krtap27-1
keratin associated protein 27-1
increases expression
ISO
Malathion results in increased expression of KRTAP27-1 mRNA
CTD
PMID:37047231
NCBI chr11:27,980,875...27,982,002
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L1td1
LINE-1 type transposase domain containing 1
affects expression multiple interactions increases methylation
EXP
Malathion affects the expression of L1TD1 mRNA [Malathion results in increased methylation of L1TD1 promoter] which affects the expression of L1TD1 mRNA
CTD
PMID:36370973
NCBI chr 5:113,373,193...113,386,088
Ensembl chr 5:113,379,870...113,385,730
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Lat
linker for activation of T cells
increases expression
EXP
Malathion results in increased expression of LAT mRNA
CTD
PMID:19784758
NCBI chr 1:180,936,536...180,941,561
Ensembl chr 1:180,936,534...180,941,578
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Lcorl
ligand dependent nuclear receptor corepressor-like
increases expression
ISO
Malathion results in increased expression of LCORL mRNA
CTD
PMID:37047231
NCBI chr14:65,271,339...65,407,732
Ensembl chr14:65,271,135...65,404,174
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Lelp1
late cornified envelope-like proline-rich 1
decreases expression
ISO
Malathion results in decreased expression of LELP1 mRNA
CTD
PMID:37047231
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Lemd1
LEM domain containing 1
increases expression
ISO
Malathion results in increased expression of LEMD1 mRNA
CTD
PMID:37047231
NCBI chr13:43,631,705...43,697,765
Ensembl chr13:43,665,926...43,697,948
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Lgals1
galectin 1
decreases expression
ISO
Malathion results in decreased expression of LGALS1 mRNA
CTD
PMID:32069766
NCBI chr 7:110,485,239...110,488,345
Ensembl chr 7:110,481,392...110,488,345
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Lif
LIF, interleukin 6 family cytokine
increases expression
ISO
Malathion results in increased expression of LIF mRNA
CTD
PMID:37047231
NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482
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Lin28b
lin-28 homolog B
increases expression
ISO
Malathion results in increased expression of LIN28B mRNA
CTD
PMID:37047231
NCBI chr20:48,865,329...48,964,769
Ensembl chr20:48,869,485...48,955,077
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Lingo1
leucine rich repeat and Ig domain containing 1
decreases expression
ISO
Malathion results in decreased expression of LINGO1 mRNA
CTD
PMID:37047231
NCBI chr 8:57,011,272...57,193,496
Ensembl chr 8:57,010,007...57,196,544
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Lmbr1
limb development membrane protein 1
increases expression
ISO
Malathion results in increased expression of LMBR1 mRNA
CTD
PMID:37047231
NCBI chr 4:5,974,687...6,146,348
Ensembl chr 4:5,974,750...6,146,368
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LOC120095955
mucin-12-like
decreases expression
ISO
Malathion results in decreased expression of MUC12 mRNA
CTD
PMID:37047231
NCBI chr12:19,486,041...19,493,995
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Lpcat4
lysophosphatidylcholine acyltransferase 4
increases expression
ISO
Malathion results in increased expression of LPCAT4 mRNA
CTD
PMID:32069766
NCBI chr 3:99,044,729...99,052,963
Ensembl chr 3:99,044,729...99,052,875
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Lrguk
leucine-rich repeats and guanylate kinase domain containing
decreases expression
ISO
Malathion results in decreased expression of LRGUK mRNA
CTD
PMID:37047231
NCBI chr 4:62,647,222...62,770,268
Ensembl chr 4:62,647,264...62,770,319
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Lrp3
LDL receptor related protein 3
decreases expression
ISO
Malathion results in decreased expression of LRP3 mRNA
CTD
PMID:37047231
NCBI chr 1:87,843,815...87,859,147
Ensembl chr 1:87,844,868...87,859,110
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Lypd1
Ly6/Plaur domain containing 1
decreases expression
ISO
Malathion results in decreased expression of LYPD1 mRNA
CTD
PMID:37047231
NCBI chr13:37,326,459...37,368,515
Ensembl chr13:37,326,464...37,368,493
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Lzts1
leucine zipper tumor suppressor 1
increases expression
ISO
Malathion results in increased expression of LZTS1 mRNA
CTD
PMID:37047231
NCBI chr16:20,542,756...20,598,204
Ensembl chr16:20,542,809...20,598,203
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Lzts2
leucine zipper tumor suppressor 2
decreases expression
ISO
Malathion results in decreased expression of LZTS2 mRNA
CTD
PMID:32069766
NCBI chr 1:243,876,665...243,888,489
Ensembl chr 1:243,880,022...243,888,423
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Macrod2
mono-ADP ribosylhydrolase 2
decreases expression
ISO
Malathion results in decreased expression of MACROD2 mRNA
CTD
PMID:37047231
NCBI chr 3:127,720,066...129,737,511
Ensembl chr 3:127,720,181...129,734,492
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Map2k3
mitogen activated protein kinase kinase 3
decreases expression
ISO
Malathion results in decreased expression of MAP2K3 mRNA
CTD
PMID:32069766
NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492
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Marchf3
membrane associated ring-CH-type finger 3
increases expression
ISO
Malathion results in increased expression of MARCHF3 mRNA
CTD
PMID:37047231
NCBI chr18:50,237,218...50,389,343
Ensembl chr18:50,237,230...50,389,150
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Mbp
myelin basic protein
decreases expression
ISO
Malathion results in decreased expression of MBP mRNA
CTD
PMID:37047231
NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404
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Mcm2
minichromosome maintenance complex component 2
multiple interactions increases expression
ISO
[Malathion co-treated with Estrogens] results in increased expression of MCM2 mRNA Malathion results in increased expression of MCM2 mRNA
CTD
PMID:18204794
NCBI chr 4:121,346,434...121,360,962
Ensembl chr 4:121,346,434...121,360,847
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Meis1
Meis homeobox 1
decreases expression
ISO
Malathion results in decreased expression of MEIS1 mRNA
CTD
PMID:37047231
NCBI chr14:93,155,426...93,294,373
Ensembl chr14:93,155,419...93,294,265
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Met
MET proto-oncogene, receptor tyrosine kinase
increases expression
ISO
Malathion results in increased expression of MET mRNA
CTD
PMID:37047231
NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
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Mfsd2a
MFSD2 lysolipid transporter A, lysophospholipid
increases expression
ISO
Malathion results in increased expression of MFSD2A mRNA
CTD
PMID:37047231
NCBI chr 5:135,225,801...135,240,744
Ensembl chr 5:135,225,816...135,240,690
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Mill1
MHC I like leukocyte 1
increases expression
ISO
Malathion results in increased expression of MICA mRNA
CTD
PMID:32069766
NCBI chr 1:78,372,798...78,398,932
Ensembl chr 1:78,372,802...78,398,930
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Mmp1
matrix metallopeptidase 1
increases expression
ISO
Malathion results in increased expression of MMP1 mRNA
CTD
PMID:37047231
NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
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Mmp10
matrix metallopeptidase 10
increases expression
ISO
Malathion results in increased expression of MMP10 mRNA
CTD
PMID:37047231
NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748
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Mmp12
matrix metallopeptidase 12
increases expression
ISO
Malathion results in increased expression of MMP12 mRNA
CTD
PMID:37047231
NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611
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Mmp3
matrix metallopeptidase 3
increases expression
ISO
Malathion results in increased expression of MMP3 mRNA
CTD
PMID:37047231
NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
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Mpo
myeloperoxidase
multiple interactions increases activity
EXP
Acetylcysteine inhibits the reaction [Malathion results in increased activity of MPO protein]
CTD
PMID:24810974 PMID:25180440
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Mt-co1
mitochondrially encoded cytochrome c oxidase I
decreases expression
ISO
Malathion results in decreased expression of COX1 mRNA
CTD
PMID:18214912
NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
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Mt-co3
mitochondrially encoded cytochrome c oxidase III
decreases expression
ISO
Malathion results in decreased expression of COX3 mRNA
CTD
PMID:18214912
NCBI chr MT:8,599...9,382 NCBI chr MT:8,599...9,382 NCBI chr MT:8,599...9,382
Ensembl chr MT:8,599...9,382
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Mt1-ps3
metallothionein 1, pseudogene 3
increases expression
ISO
Malathion results in increased expression of MT1E mRNA
CTD
PMID:37047231
NCBI chr17:74,786,652...74,787,040
Ensembl chr17:74,786,654...74,787,135
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Mt2A
metallothionein 2A
increases expression
ISO
Malathion results in increased expression of MT2A mRNA
CTD
PMID:37047231
NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
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Mybphl
myosin binding protein H-like
increases expression
ISO
Malathion results in increased expression of MYBPHL mRNA
CTD
PMID:37047231
NCBI chr 2:196,005,297...196,018,826
Ensembl chr 2:196,005,325...196,018,824
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Myo1b
myosin Ib
increases expression
ISO
Malathion results in increased expression of MYO1B mRNA
CTD
PMID:37047231
NCBI chr 9:49,690,043...49,852,373
Ensembl chr 9:49,690,086...49,850,798
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Myzap
myocardial zonula adherens protein
increases expression
ISO
Malathion results in increased expression of MYZAP mRNA
CTD
PMID:37047231
NCBI chr 8:72,155,817...72,243,036
Ensembl chr 8:72,131,530...72,243,036
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Ndufs7
NADH:ubiquinone oxidoreductase core subunit S7
decreases expression
ISO
Malathion results in decreased expression of NDUFS7 mRNA
CTD
PMID:37047231
NCBI chr 7:9,452,556...9,460,135
Ensembl chr 7:9,450,392...9,460,195
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Nefh
neurofilament heavy chain
affects expression increases expression
EXP
Malathion affects the expression of NEFH mRNA Malathion results in increased expression of NEFH mRNA
CTD
PMID:22954530 PMID:28385489
NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
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Nek10
NIMA-related kinase 10
decreases expression
ISO
Malathion results in decreased expression of NEK10 mRNA
CTD
PMID:37047231
NCBI chr15:10,387,063...10,564,177
Ensembl chr15:10,381,140...10,559,722
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Neu4
neuraminidase 4
increases expression
ISO
Malathion results in increased expression of NEU4 mRNA
CTD
PMID:37047231
NCBI chr 9:94,396,920...94,402,576
Ensembl chr 9:94,396,920...94,402,576
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Neurl3
neuralized E3 ubiquitin protein ligase 3
increases expression
ISO
Malathion results in increased expression of NEURL3 mRNA
CTD
PMID:37047231
NCBI chr 9:38,494,486...38,503,352
Ensembl chr 9:38,494,489...38,502,649
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Nfe2l2
NFE2 like bZIP transcription factor 2
increases activity
ISO
Malathion results in increased activity of NFE2L2 protein
CTD
PMID:30114225 PMID:30203046
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nfib
nuclear factor I/B
decreases expression
ISO
Malathion results in decreased expression of NFIB mRNA
CTD
PMID:37047231
NCBI chr 5:96,759,208...96,974,001
Ensembl chr 5:96,764,653...96,975,479
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Ngf
nerve growth factor
multiple interactions
EXP
Malathion promotes the reaction [NGF protein results in increased expression of CAMK2A mRNA]; Malathion promotes the reaction [NGF protein results in increased expression of CAMK2B mRNA]
CTD
PMID:28385489
NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
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Ninj1
ninjurin 1
decreases expression
ISO
Malathion results in decreased expression of NINJ1 mRNA
CTD
PMID:32069766
NCBI chr17:15,452,804...15,461,684
Ensembl chr17:15,452,813...15,461,704
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Nnt
nicotinamide nucleotide transhydrogenase
decreases expression
ISO
Malathion results in decreased expression of NNT mRNA
CTD
PMID:37047231
NCBI chr 2:51,411,413...51,505,125
Ensembl chr 2:51,411,413...51,504,823
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Nos2
nitric oxide synthase 2
increases expression
EXP
Malathion results in increased expression of NOS2 mRNA
CTD
PMID:20233601
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Nqo1
NAD(P)H quinone dehydrogenase 1
increases expression
ISO
Malathion results in increased expression of NQO1 mRNA
CTD
PMID:17311802
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Nr1i3
nuclear receptor subfamily 1, group I, member 3
increases expression increases activity
ISO
Malathion results in increased expression of NR1I3 mRNA Malathion results in increased activity of NR1I3 protein
CTD
PMID:22310298 PMID:28927721 PMID:30203046
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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Nr4a1
nuclear receptor subfamily 4, group A, member 1
increases expression
ISO
Malathion results in increased expression of NR4A1 mRNA
CTD
PMID:37047231
NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
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Nr4a3
nuclear receptor subfamily 4, group A, member 3
decreases methylation increases expression
ISO
Malathion results in decreased methylation of NR4A3 promoter Malathion results in increased expression of NR4A3 mRNA
CTD
PMID:37047231
NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733
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Ntn1
netrin 1
increases expression
ISO
Malathion results in increased expression of NTN1 mRNA
CTD
PMID:37047231
NCBI chr10:52,899,933...53,098,591
Ensembl chr10:52,899,934...53,085,326
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Ntrk2
neurotrophic receptor tyrosine kinase 2
increases expression
ISO
Malathion results in increased expression of NTRK2 mRNA
CTD
PMID:32069766
NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
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Ocln
occludin
multiple interactions decreases expression
EXP
[Malathion co-treated with Lead] results in decreased expression of OCLN protein Malathion results in decreased expression of OCLN protein
CTD
PMID:20970449
NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
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Ocstamp
osteoclast stimulatory transmembrane protein
increases expression
ISO
Malathion results in increased expression of OCSTAMP mRNA
CTD
PMID:37047231
NCBI chr 3:154,131,113...154,141,611
Ensembl chr 3:154,132,328...154,136,991
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Odam
odontogenic, ameloblast associated
decreases expression
ISO
Malathion results in decreased expression of ODAM mRNA
CTD
PMID:37047231
NCBI chr14:20,193,286...20,202,517
Ensembl chr14:20,193,302...20,202,517
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Odf2l
outer dense fiber of sperm tails 2-like
decreases expression
ISO
Malathion results in decreased expression of ODF2L mRNA
CTD
PMID:37047231
NCBI chr 2:234,036,049...234,072,751
Ensembl chr 2:234,033,652...234,072,747
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Olr1433
olfactory receptor 1433
increases expression
ISO
Malathion results in increased expression of OR2W3 mRNA
CTD
PMID:37047231
NCBI chr10:43,042,427...43,046,293
Ensembl chr10:43,037,857...43,046,701
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Olr1523
olfactory receptor 1523
decreases expression
ISO
Malathion results in decreased expression of OR4D1 mRNA
CTD
PMID:37047231
NCBI chr10:72,708,272...72,709,213
Ensembl chr10:72,707,063...72,715,311
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Olr35
olfactory receptor 35
decreases expression
ISO
Malathion results in decreased expression of OR2AT4 mRNA
CTD
PMID:37047231
NCBI chr 1:153,994,678...154,043,281
Ensembl chr 1:154,041,306...154,043,257
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Omg
oligodendrocyte-myelin glycoprotein
affects expression
ISO
Malathion affects the expression of OMG mRNA
CTD
PMID:37047231
NCBI chr10:64,461,350...64,464,084
Ensembl chr10:64,461,350...64,464,084
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Opn5
opsin 5
decreases expression
ISO
Malathion results in decreased expression of OPN5 mRNA
CTD
PMID:37047231
NCBI chr 9:18,368,393...18,416,098
Ensembl chr 9:18,368,416...18,415,476
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Or4f7
olfactory receptor family 4 subfamily F member 7
decreases expression
ISO
Malathion results in decreased expression of OR4F29 mRNA
CTD
PMID:37047231
NCBI chr 3:98,482,895...98,483,833
Ensembl chr 3:98,481,730...98,489,462
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Or4f7c
olfactory receptor family 4 subfamily F member 7C
decreases expression
ISO
Malathion results in decreased expression of OR4F21 mRNA
CTD
PMID:37047231
NCBI chr 3:98,458,889...98,459,827
Ensembl chr 3:98,457,871...98,464,794
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Or6c2
olfactory receptor family 6 subfamily C member 2
decreases expression
ISO
Malathion results in decreased expression of OR6C2 mRNA
CTD
PMID:37047231
NCBI chr 7:2,188,601...2,189,539
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Or9g4
olfactory receptor family 9 subfamily G member 4
decreases expression
ISO
Malathion results in decreased expression of OR9G4 mRNA
CTD
PMID:37047231
NCBI chr 3:70,727,963...70,728,901
Ensembl chr 3:70,726,935...70,732,439
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P2rx1
purinergic receptor P2X 1
increases expression
EXP
Malathion results in increased expression of P2RX1 mRNA
CTD
PMID:19784758
NCBI chr10:57,618,586...57,633,648
Ensembl chr10:57,618,586...57,633,623
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Palmd
palmdelphin
decreases expression
ISO
Malathion results in decreased expression of PALMD mRNA
CTD
PMID:37047231
NCBI chr 2:204,889,526...204,941,355
Ensembl chr 2:204,889,533...204,941,519
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Parp1
poly (ADP-ribose) polymerase 1
increases cleavage multiple interactions
ISO
Malathion results in increased cleavage of PARP1 protein Metoclopramide inhibits the reaction [Malathion results in increased cleavage of PARP1 protein]
CTD
PMID:29027213
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Pax1
paired box 1
increases expression
ISO
Malathion results in increased expression of PAX1 mRNA
CTD
PMID:32069766
NCBI chr 3:134,792,330...134,801,637
Ensembl chr 3:134,789,182...134,801,636
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Pcdh15
protocadherin related 15
decreases expression
ISO
Malathion results in decreased expression of PCDH15 mRNA
CTD
PMID:37047231
NCBI chr20:13,997,094...15,496,446
Ensembl chr20:13,963,565...15,494,719
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Pcdhb19
protocadherin beta 19
decreases expression
ISO
Malathion results in decreased expression of PCDHB12 mRNA
CTD
PMID:37047231
NCBI chr18:29,204,838...29,207,646
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Pcdhgb1
protocadherin gamma subfamily B, 1
increases expression
ISO
Malathion results in increased expression of PCDHGB1 mRNA
CTD
PMID:37047231
NCBI chr18:29,501,739...29,508,024
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Pck1
phosphoenolpyruvate carboxykinase 1
multiple interactions increases expression
EXP
Acetylcysteine inhibits the reaction [Malathion results in increased expression of PCK1 mRNA]
CTD
PMID:25449180
NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
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Pcna
proliferating cell nuclear antigen
multiple interactions increases expression
ISO
Atropine inhibits the reaction [Malathion results in increased expression of PCNA]
CTD
PMID:12762645
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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Pde6c
phosphodiesterase 6C
decreases expression
ISO
Malathion results in decreased expression of PDE6C mRNA
CTD
PMID:37047231
NCBI chr 1:235,909,583...235,965,435
Ensembl chr 1:235,909,775...235,965,315
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Pdia2
protein disulfide isomerase family A, member 2
decreases expression
ISO
Malathion results in decreased expression of PDIA2 mRNA
CTD
PMID:37047231
NCBI chr10:15,215,824...15,218,937
Ensembl chr10:15,215,824...15,220,931
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Pebp1
phosphatidylethanolamine binding protein 1
decreases expression
ISO
Malathion results in decreased expression of PEBP1 mRNA
CTD
PMID:32069766
NCBI chr12:39,302,864...39,307,064
Ensembl chr12:39,302,840...39,307,862
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Peg10
paternally expressed 10
increases expression
ISO
Malathion results in increased expression of PEG10 mRNA
CTD
PMID:37047231
NCBI chr 4:32,842,441...32,855,639
Ensembl chr 4:32,848,493...32,852,621
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Pfn1
profilin 1
decreases expression
ISO
Malathion results in decreased expression of PFN1 mRNA
CTD
PMID:32069766
NCBI chr10:55,365,263...55,367,968
Ensembl chr10:55,365,262...55,527,631
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Phb1
prohibitin 1
decreases expression
ISO
Malathion results in decreased expression of PHB1 mRNA
CTD
PMID:32069766
NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042
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Pitx1
paired-like homeodomain 1
decreases expression
ISO
Malathion results in decreased expression of PITX1 mRNA
CTD
PMID:37047231
NCBI chr17:8,794,134...8,800,292
Ensembl chr17:8,794,134...8,800,291
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Plat
plasminogen activator, tissue type
decreases expression
ISO
Malathion results in decreased expression of PLAT mRNA
CTD
PMID:16079077
NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
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Plau
plasminogen activator, urokinase
increases expression
ISO
Malathion results in increased expression of PLAU mRNA
CTD
PMID:32069766
NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
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Plaur
plasminogen activator, urokinase receptor
increases expression
ISO
Malathion results in increased expression of PLAUR mRNA
CTD
PMID:37047231
NCBI chr 1:80,053,440...80,068,384
Ensembl chr 1:80,050,324...80,068,595
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Plcb4
phospholipase C, beta 4
increases expression
ISO
Malathion results in increased expression of PLCB4 mRNA
CTD
PMID:37047231
NCBI chr 3:122,952,965...123,322,522
Ensembl chr 3:122,953,196...123,322,392
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Plekhd1
pleckstrin homology and coiled-coil domain containing D1
decreases expression
ISO
Malathion results in decreased expression of PLEKHD1 mRNA
CTD
PMID:37047231
NCBI chr 6:100,340,655...100,371,942
Ensembl chr 6:100,340,655...100,371,941
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Plin1
perilipin 1
increases expression
ISO
Malathion results in increased expression of PLIN1 mRNA
CTD
PMID:37047231
NCBI chr 1:133,664,294...133,676,854
Ensembl chr 1:133,664,892...133,676,828
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Plin2
perilipin 2
increases expression
ISO
Malathion results in increased expression of PLIN2 mRNA
CTD
PMID:37047231
NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319
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Plp1
proteolipid protein 1
decreases expression
ISO
Malathion results in decreased expression of PLP1 mRNA
CTD
PMID:37047231
NCBI chr X:100,184,039...100,201,035
Ensembl chr X:100,185,767...100,201,032
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Pls3
plastin 3
increases expression
ISO
Malathion results in increased expression of PLS3 mRNA
CTD
PMID:37047231
NCBI chr X:111,589,193...111,683,908
Ensembl chr X:111,589,254...111,683,891
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Plvap
plasmalemma vesicle associated protein
decreases expression
ISO
Malathion results in decreased expression of PLVAP mRNA
CTD
PMID:37047231
NCBI chr16:18,184,985...18,197,301
Ensembl chr16:18,184,975...18,197,301
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Pml
PML nuclear body scaffold
decreases expression
ISO
Malathion results in decreased expression of PML mRNA
CTD
PMID:32069766
NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971
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Ppara
peroxisome proliferator activated receptor alpha
decreases expression
ISO
Malathion results in decreased expression of PPARA mRNA
CTD
PMID:25689681
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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Prkd1
protein kinase D1
increases expression
ISO
Malathion results in increased expression of PRKD1 mRNA
CTD
PMID:32069766
NCBI chr 6:67,725,193...68,039,002
Ensembl chr 6:67,725,905...68,039,042
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Prox2
prospero homeobox 2
decreases expression
ISO
Malathion results in decreased expression of PROX2 mRNA
CTD
PMID:37047231
NCBI chr 6:104,731,385...104,758,619
Ensembl chr 6:104,733,002...104,742,093
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Proz
protein Z, vitamin K-dependent plasma glycoprotein
decreases expression
ISO
Malathion results in decreased expression of PROZ mRNA
CTD
PMID:37047231
NCBI chr16:76,450,013...76,463,558
Ensembl chr16:76,450,013...76,463,480
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Ptcra
pre T-cell antigen receptor alpha
decreases expression
ISO
Malathion results in decreased expression of PTCRA mRNA
CTD
PMID:37047231
NCBI chr 9:14,218,907...14,229,141
Ensembl chr 9:14,218,802...14,229,235
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Ptgs2
prostaglandin-endoperoxide synthase 2
increases expression
ISO
Malathion results in increased expression of PTGS2 mRNA; Malathion results in increased expression of PTGS2 protein
CTD
PMID:30673264
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Pygl
glycogen phosphorylase L
multiple interactions increases expression
EXP
Acetylcysteine inhibits the reaction [Malathion results in increased expression of PYGL mRNA]
CTD
PMID:25449180
NCBI chr 6:88,697,598...88,740,260
Ensembl chr 6:88,697,593...88,740,310
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Rab11fip3
RAB11 family interacting protein 3
increases expression
ISO
Malathion results in increased expression of RAB11FIP3 mRNA
CTD
PMID:32069766
NCBI chr10:15,002,650...15,086,382
Ensembl chr10:15,002,926...15,118,479
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Rab3c
RAB3C, member RAS oncogene family
decreases expression
ISO
Malathion results in decreased expression of RAB3C mRNA
CTD
PMID:37047231
NCBI chr 2:41,627,720...41,843,541
Ensembl chr 2:41,627,720...41,843,749
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Rapgef5
Rap guanine nucleotide exchange factor 5
increases expression
ISO
Malathion results in increased expression of RAPGEF5 mRNA
CTD
PMID:37047231
NCBI chr 6:138,445,184...138,679,943
Ensembl chr 6:138,437,991...138,679,936
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Rbp3
retinol binding protein 3
decreases expression
ISO
Malathion results in decreased expression of RBP3 mRNA
CTD
PMID:37047231
NCBI chr16:9,267,538...9,276,006
Ensembl chr16:9,267,538...9,276,006
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Rbp7
retinol binding protein 7
decreases expression
ISO
Malathion results in decreased expression of RBP7 mRNA
CTD
PMID:37047231
NCBI chr 5:159,889,723...159,894,338
Ensembl chr 5:159,889,723...159,894,339
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Redic1
regulator of DNA class I crossover intermediates 1
decreases expression
ISO
Malathion results in decreased expression of REDIC1 mRNA
CTD
PMID:37047231
NCBI chr 7:122,318,495...122,386,002
Ensembl chr 7:122,318,499...122,385,983
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Rela
RELA proto-oncogene, NF-kB subunit
increases expression multiple interactions
EXP ISO
Malathion results in increased expression of RELA mRNA Taurine inhibits the reaction [Malathion results in increased expression of RELA mRNA]
CTD
PMID:28987951 PMID:30673264
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Reln
reelin
increases expression
ISO
Malathion results in increased expression of RELN mRNA
CTD
PMID:37047231
NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211
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Rfc3
replication factor C subunit 3
decreases expression
ISO
Malathion results in decreased expression of RFC3 mRNA
CTD
PMID:16079077
NCBI chr12:1,000,987...1,011,778
Ensembl chr12:1,000,994...1,011,778
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Rft1
RFT1 homolog
decreases expression
ISO
Malathion results in decreased expression of RFT1 mRNA
CTD
PMID:37047231
NCBI chr16:5,827,063...5,861,120
Ensembl chr16:5,827,088...5,861,120
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Rhoa
ras homolog family member A
decreases activity
ISO
Malathion results in decreased activity of RHOA protein
CTD
PMID:37270087
NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
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Rhox13
Rhox homeobox family member 13
increases expression
ISO
Malathion results in increased expression of RHOXF1 mRNA
CTD
PMID:37047231
NCBI chr X:116,911,226...116,917,758
Ensembl chr X:116,911,329...116,917,644
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Rimbp2
RIMS binding protein 2
decreases expression
ISO
Malathion results in decreased expression of RIMBP2 mRNA
CTD
PMID:37047231
NCBI chr12:27,747,615...27,946,256
Ensembl chr12:27,747,980...27,956,763
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Rnase6
ribonuclease A family member k6
increases expression
EXP
Malathion results in increased expression of RNASE6 mRNA
CTD
PMID:19784758
NCBI chr15:24,354,305...24,357,289
Ensembl chr15:24,354,303...24,357,328
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Rnf170
ring finger protein 170
increases expression
ISO
Malathion results in increased expression of RNF170 mRNA
CTD
PMID:37047231
NCBI chr16:65,928,886...65,954,092
Ensembl chr16:65,928,895...65,954,083
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Rnf183
ring finger protein 183
increases expression
ISO
Malathion results in increased expression of RNF183 mRNA
CTD
PMID:37047231
NCBI chr 5:75,877,111...75,886,253
Ensembl chr 5:75,876,003...75,886,191
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Robo4
roundabout guidance receptor 4
decreases expression
ISO
Malathion results in decreased expression of ROBO4 mRNA
CTD
PMID:37047231
NCBI chr 8:37,119,953...37,133,887
Ensembl chr 8:37,119,988...37,132,519
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Rph3a
rabphilin 3A
decreases expression
ISO
Malathion results in decreased expression of RPH3A mRNA
CTD
PMID:37047231
NCBI chr12:35,542,389...35,618,901
Ensembl chr12:35,542,728...35,617,592
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Rrad
RRAD, Ras related glycolysis inhibitor and calcium channel regulator
increases expression
ISO
Malathion results in increased expression of RRAD mRNA
CTD
PMID:37047231
NCBI chr19:354,184...357,424
Ensembl chr19:354,198...357,417
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Rs1
retinoschisin 1
increases expression
ISO
Malathion results in increased expression of RS1 mRNA
CTD
PMID:37047231
NCBI chr X:33,962,440...33,992,203
Ensembl chr X:33,963,657...33,992,115
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Rsad2
radical S-adenosyl methionine domain containing 2
increases expression
ISO
Malathion results in increased expression of RSAD2 mRNA
CTD
PMID:37047231
NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699
G
Rspo2
R-spondin 2
decreases expression
ISO
Malathion results in decreased expression of RSPO2 mRNA
CTD
PMID:37047231
NCBI chr 7:74,096,378...74,239,398
Ensembl chr 7:74,103,090...74,238,933
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RT1-A2
RT1 class Ia, locus A2
decreases expression
ISO
Malathion results in decreased expression of HLA-E mRNA
CTD
PMID:32069766
NCBI chr20:4,870,939...4,910,183
G
RT1-CE16
RT1 class I, locus CE16
decreases expression
ISO
Malathion results in decreased expression of HLA-A mRNA
CTD
PMID:32069766
NCBI chr20:3,257,109...3,260,747
Ensembl chr20:3,257,123...3,279,563
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Runx1
RUNX family transcription factor 1
increases expression
ISO
Malathion results in increased expression of RUNX1 mRNA mutant form
CTD
PMID:28624474
NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542
G
S100a1
S100 calcium binding protein A1
decreases expression
ISO
Malathion results in decreased expression of S100A1 mRNA
CTD
PMID:37047231
NCBI chr 2:175,993,922...175,998,765
Ensembl chr 2:175,993,922...175,999,544
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Scg5
secretogranin V
increases expression
ISO
Malathion results in increased expression of SCG5 mRNA
CTD
PMID:37047231
NCBI chr 3:100,544,101...100,588,558
Ensembl chr 3:100,544,099...100,588,463
G
Scn9a
sodium voltage-gated channel alpha subunit 9
decreases expression
ISO
Malathion results in decreased expression of SCN9A mRNA
CTD
PMID:37047231
NCBI chr 3:51,145,148...51,293,342
Ensembl chr 3:51,145,146...51,293,516
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Serpinb2
serpin family B member 2
increases expression
ISO
Malathion results in increased expression of SERPINB2 mRNA
CTD
PMID:37047231
NCBI chr13:23,537,312...23,551,823
Ensembl chr13:23,541,400...23,550,408
G
Sftpb
surfactant protein B
decreases expression
ISO
Malathion results in decreased expression of SFTPB mRNA
CTD
PMID:37047231
NCBI chr 4:104,359,303...104,368,439
Ensembl chr 4:104,359,396...104,368,436
G
Sgpp2
sphingosine-1-phosphate phosphatase 2
increases expression
ISO
Malathion results in increased expression of SGPP2 mRNA
CTD
PMID:37047231
NCBI chr 9:79,762,658...79,884,665
Ensembl chr 9:79,763,284...79,880,457
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Shc1
SHC adaptor protein 1
increases expression
ISO
Malathion results in increased expression of SHC1 mRNA
CTD
PMID:32069766
NCBI chr 2:174,837,937...174,849,538
Ensembl chr 2:174,837,930...174,849,536
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Shisa3
shisa family member 3
increases expression
ISO
Malathion results in increased expression of SHISA3 mRNA
CTD
PMID:37047231
NCBI chr14:40,563,672...40,568,244
Ensembl chr14:40,563,673...40,568,244
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Shisa9
shisa family member 9
increases expression
ISO
Malathion results in increased expression of SHISA9 mRNA
CTD
PMID:37047231
NCBI chr10:3,335,616...3,629,334
Ensembl chr10:3,337,979...3,627,773
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Shtn1
shootin 1
decreases expression
ISO
Malathion results in decreased expression of SHTN1 mRNA
CTD
PMID:37047231
NCBI chr 1:258,121,966...258,225,861
Ensembl chr 1:258,121,968...258,228,265
G
Slc14a1
solute carrier family 14 member 1 (Kidd blood group)
decreases expression
ISO
Malathion results in decreased expression of SLC14A1 mRNA
CTD
PMID:37047231
NCBI chr18:71,565,453...71,608,807
Ensembl chr18:71,565,454...71,595,146
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Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Malathion inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]
CTD
PMID:23770354
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Slc22a6
solute carrier family 22 member 6
multiple interactions
ISO
Malathion inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]
CTD
PMID:21561794
NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
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Slc4a5
solute carrier family 4 member 5
decreases expression
ISO
Malathion results in decreased expression of SLC4A5 mRNA
CTD
PMID:37047231
NCBI chr 4:115,710,101...115,810,330
Ensembl chr 4:115,725,592...115,810,323
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Slco4a1
solute carrier organic anion transporter family, member 4a1
increases expression
ISO
Malathion results in increased expression of SLCO4A1 mRNA
CTD
PMID:37047231
NCBI chr 3:167,559,177...167,578,307
Ensembl chr 3:167,559,316...167,578,305
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Smim32
small integral membrane protein 32
decreases expression
ISO
Malathion results in decreased expression of SMIM32 mRNA
CTD
PMID:37047231
NCBI chr17:7,853,492...7,857,235
G
Snca
synuclein alpha
increases expression multiple interactions
EXP
Malathion results in increased expression of SNCA mRNA; Malathion results in increased expression of SNCA protein crocin inhibits the reaction [Malathion results in increased expression of SNCA mRNA]; crocin inhibits the reaction [Malathion results in increased expression of SNCA protein]; Levodopa inhibits the reaction [Malathion results in increased expression of SNCA mRNA]; Levodopa inhibits the reaction [Malathion results in increased expression of SNCA protein]
CTD
PMID:35274200
NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
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Sntg1
syntrophin, gamma 1
decreases expression
ISO
Malathion results in decreased expression of SNTG1 mRNA
CTD
PMID:37047231
NCBI chr 5:9,980,550...10,794,666
Ensembl chr 5:9,981,115...10,791,181
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Socs3
suppressor of cytokine signaling 3
decreases expression
ISO
Malathion results in decreased expression of SOCS3 mRNA
CTD
PMID:32069766
NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
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Sod1
superoxide dismutase 1
increases activity decreases expression multiple interactions
EXP ISO
Malathion results in increased activity of SOD1 protein Malathion results in decreased expression of SOD1 protein lavender oil inhibits the reaction [Malathion results in decreased expression of SOD1 protein] alpha-Tocopherol inhibits the reaction [Malathion results in increased activity of SOD1 protein]
CTD
PMID:20194575 PMID:30409133
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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Sod2
superoxide dismutase 2
multiple interactions decreases expression
EXP ISO
alpha-Tocopherol inhibits the reaction [Malathion results in increased activity of SOD2 protein]; Malathion results in increased expression of and results in increased activity of SOD2 protein lavender oil inhibits the reaction [Malathion results in decreased expression of SOD2 protein]
CTD
PMID:20194575 PMID:30409133
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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Spata17
spermatogenesis associated 17
decreases expression
ISO
Malathion results in decreased expression of SPATA17 mRNA
CTD
PMID:37047231
NCBI chr13:98,605,986...98,784,855
Ensembl chr13:98,605,986...98,784,929
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Spdya
speedy/RINGO cell cycle regulator family member A
increases expression
ISO
Malathion results in increased expression of SPDYA mRNA
CTD
PMID:37047231
NCBI chr 6:23,905,574...23,954,926
Ensembl chr 6:23,910,223...23,954,850
G
Spink13
serine peptidase inhibitor Kazal type 13
decreases expression
ISO
Malathion results in decreased expression of SPINK13 mRNA
CTD
PMID:37047231
NCBI chr18:56,064,839...56,206,257
Ensembl chr18:56,064,839...56,206,257
G
Spink4
serine peptidase inhibitor, Kazal type 4
decreases expression
ISO
Malathion results in decreased expression of SPINK4 mRNA
CTD
PMID:37047231
NCBI chr 5:56,043,936...56,064,841
Ensembl chr 5:55,981,624...56,064,795
G
Srsf5
serine and arginine rich splicing factor 5
decreases expression
EXP
Malathion results in decreased expression of SRSF5 mRNA
CTD
PMID:19784758
NCBI chr 6:100,605,165...100,610,192
Ensembl chr 6:100,605,456...100,610,177
G
Sspo
SCO-spondin
decreases expression
ISO
Malathion results in decreased expression of SSPOP mRNA
CTD
PMID:37047231
NCBI chr 4:77,394,915...77,450,526
Ensembl chr 4:77,397,059...77,450,412
G
Sst
somatostatin
decreases expression
ISO
Malathion results in decreased expression of SST mRNA
CTD
PMID:37047231
NCBI chr11:76,956,896...76,958,173
Ensembl chr11:76,956,896...76,958,173
G
Sstr2
somatostatin receptor 2
increases expression
ISO
Malathion results in increased expression of SSTR2 mRNA
CTD
PMID:37047231
NCBI chr10:98,664,204...98,671,370
Ensembl chr10:98,664,216...98,674,351
G
St6gal2
ST6 beta-galactoside alpha-2,6-sialyltransferase 2
increases expression
ISO
Malathion results in increased expression of ST6GAL2 mRNA
CTD
PMID:37047231
NCBI chr 9:9,181,744...9,274,161
Ensembl chr 9:9,182,399...9,269,697
G
St8sia1
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1
increases expression
EXP
Malathion results in increased expression of ST8SIA1 mRNA
CTD
PMID:19784758
NCBI chr 4:175,782,989...175,921,338
Ensembl chr 4:175,789,947...175,920,708
G
St8sia4
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
increases expression
ISO
Malathion results in increased expression of ST8SIA4 mRNA
CTD
PMID:37047231
NCBI chr 9:95,990,131...96,084,661
Ensembl chr 9:95,993,503...96,084,653
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Star
steroidogenic acute regulatory protein
decreases expression multiple interactions
ISO
Malathion results in decreased expression of STAR mRNA lavender oil inhibits the reaction [Malathion results in decreased expression of STAR mRNA]
CTD
PMID:30409133
NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
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Stat3
signal transducer and activator of transcription 3
decreases phosphorylation
EXP
Malathion results in decreased phosphorylation of STAT3 protein
CTD
PMID:34778934
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Stat5b
signal transducer and activator of transcription 5B
decreases activity
ISO
Malathion results in decreased activity of STAT5B protein
CTD
PMID:30114225
NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668
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Stk36
serine/threonine kinase 36
decreases expression
ISO
Malathion results in decreased expression of STK36 mRNA
CTD
PMID:37047231
NCBI chr 9:76,176,922...76,204,423
Ensembl chr 9:76,176,920...76,204,422
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Stra6
signaling receptor and transporter of retinol STRA6
decreases expression
ISO
Malathion results in decreased expression of STRA6 mRNA
CTD
PMID:37047231
NCBI chr 8:58,548,899...58,568,861
Ensembl chr 8:58,549,736...58,568,860
G
Tcf7l1
transcription factor 7 like 1
increases expression
ISO
Malathion results in increased expression of TCF7L1 mRNA
CTD
PMID:37047231
NCBI chr 4:104,680,734...104,846,086
Ensembl chr 4:104,680,739...104,845,287
G
Tchhl1
trichohyalin-like 1
decreases expression
ISO
Malathion results in decreased expression of TCHHL1 mRNA
CTD
PMID:37047231
NCBI chr 2:179,134,941...179,138,467
Ensembl chr 2:179,135,796...179,138,202
G
Tdrd1
tudor domain containing 1
increases expression
ISO
Malathion results in increased expression of TDRD1 mRNA
CTD
PMID:37047231
NCBI chr 1:255,871,939...255,919,222
Ensembl chr 1:255,875,887...255,915,871
G
Tdrd6
tudor domain containing 6
increases expression
ISO
Malathion results in increased expression of TDRD6 mRNA
CTD
PMID:37047231
NCBI chr 9:17,344,033...17,359,348
Ensembl chr 9:17,344,026...17,359,344
G
Tdrp
testis development related protein
decreases expression
ISO
Malathion results in decreased expression of TDRP mRNA
CTD
PMID:37047231
NCBI chr16:75,624,047...75,652,635
Ensembl chr16:75,624,907...75,652,420
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Tek
TEK receptor tyrosine kinase
increases expression
ISO
Malathion results in increased expression of TEK mRNA
CTD
PMID:32069766
NCBI chr 5:109,607,077...109,733,805
Ensembl chr 5:109,607,077...109,733,804
G
Tet1
tet methylcytosine dioxygenase 1
affects expression
EXP
Malathion affects the expression of TET1 mRNA
CTD
PMID:36370973
NCBI chr20:25,761,042...25,840,926
Ensembl chr20:25,768,120...25,833,052
G
Tet2
tet methylcytosine dioxygenase 2
decreases expression
EXP
Malathion results in decreased expression of TET2 mRNA
CTD
PMID:36370973
NCBI chr 2:221,988,645...222,072,813
Ensembl chr 2:221,988,645...222,072,534
G
Tet3
tet methylcytosine dioxygenase 3
affects expression
EXP
Malathion affects the expression of TET3 mRNA
CTD
PMID:36370973
NCBI chr 4:115,867,412...115,964,433
Ensembl chr 4:115,871,265...115,964,193
G
Tfpi2
tissue factor pathway inhibitor 2
increases expression
ISO
Malathion results in increased expression of TFPI2 mRNA
CTD
PMID:37047231
NCBI chr 4:31,981,786...31,986,707
Ensembl chr 4:31,982,178...31,986,600
G
Tfrc
transferrin receptor
increases expression
ISO
Malathion results in increased expression of TFRC mRNA
CTD
PMID:32069766
NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
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Tg
thyroglobulin
decreases expression
EXP
Malathion results in decreased expression of TG mRNA; Malathion results in decreased expression of TG protein
CTD
PMID:29143548
NCBI chr 7:98,418,293...98,603,210
Ensembl chr 7:98,418,293...98,603,210
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Tifab
TIFA inhibitor
decreases expression
ISO
Malathion results in decreased expression of TIFAB mRNA
CTD
PMID:37047231
NCBI chr17:8,433,406...8,436,541
Ensembl chr17:8,431,635...8,436,592
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Timp3
TIMP metallopeptidase inhibitor 3
decreases expression
EXP
Malathion results in decreased expression of TIMP3 mRNA
CTD
PMID:19784758
NCBI chr 7:17,520,827...17,571,850
Ensembl chr 7:17,521,919...17,571,839
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Tjp1
tight junction protein 1
multiple interactions decreases expression
EXP
[Malathion co-treated with Lead] results in decreased expression of TJP1 protein Malathion results in decreased expression of TJP1 protein
CTD
PMID:20970449
NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
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Tjp2
tight junction protein 2
multiple interactions decreases expression
EXP
[Malathion co-treated with Lead] results in decreased expression of TJP2 protein Malathion results in decreased expression of TJP2 protein
CTD
PMID:20970449
NCBI chr 1:221,709,745...221,838,291
Ensembl chr 1:221,709,745...221,838,295
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Tlr4
toll-like receptor 4
multiple interactions increases expression
ISO
Plant Extracts inhibits the reaction [Malathion results in increased expression of TLR4 protein]; Polyphenols inhibits the reaction [Malathion results in increased expression of TLR4 protein]
CTD
PMID:32120800
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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Tlr8
toll-like receptor 8
increases expression
ISO
Malathion results in increased expression of TLR8 mRNA
CTD
PMID:32069766
NCBI chr X:27,091,780...27,116,092
Ensembl chr X:27,091,778...27,116,549
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Tmem114
transmembrane protein 114
decreases expression
ISO
Malathion results in decreased expression of TMEM114 mRNA
CTD
PMID:37047231
NCBI chr10:7,168,998...7,185,251
Ensembl chr10:7,169,746...7,185,251
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Tmem158
transmembrane protein 158
increases expression
ISO
Malathion results in increased expression of TMEM158 mRNA
CTD
PMID:37047231
NCBI chr 8:122,913,675...122,914,673
Ensembl chr 8:122,913,675...122,914,673
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Tmem241
transmembrane protein 241
decreases expression
ISO
Malathion results in decreased expression of TMEM241 mRNA
CTD
PMID:37047231
NCBI chr18:3,168,072...3,318,340
Ensembl chr18:3,168,067...3,318,293
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Tmem65
transmembrane protein 65
increases expression
ISO
Malathion results in increased expression of TMEM65 mRNA
CTD
PMID:37047231
NCBI chr 7:90,336,997...90,378,930
Ensembl chr 7:90,274,142...90,379,474
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Tnf
tumor necrosis factor
increases expression multiple interactions
EXP ISO
Malathion results in increased expression of TNF mRNA Taurine inhibits the reaction [Malathion results in increased expression of TNF mRNA]
CTD
PMID:28987951 PMID:37047231
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnfaip6
TNF alpha induced protein 6
increases expression
ISO
Malathion results in increased expression of TNFAIP6 mRNA
CTD
PMID:37047231
NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649
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Tnfaip8l3
TNF alpha induced protein 8 like 3
decreases expression
ISO
Malathion results in decreased expression of TNFAIP8L3 mRNA
CTD
PMID:37047231
NCBI chr 8:54,413,503...54,455,512
Ensembl chr 8:54,414,457...54,500,079
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Tnfsf15
TNF superfamily member 15
affects expression
ISO
Malathion affects the expression of TNFSF15 mRNA
CTD
PMID:37047231
NCBI chr 5:77,134,885...77,156,171
Ensembl chr 5:77,139,878...77,156,228
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Tnip3
TNFAIP3 interacting protein 3
increases expression
ISO
Malathion results in increased expression of TNIP3 mRNA
CTD
PMID:37047231
NCBI chr 4:94,867,258...94,908,780
Ensembl chr 4:94,811,097...94,907,605
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Tp53
tumor protein p53
multiple interactions increases expression
ISO EXP
Atropine inhibits the reaction [Malathion results in increased expression of TP53 protein] Plant Extracts inhibits the reaction [Malathion results in increased expression of TRP53 protein]; Polyphenols inhibits the reaction [Malathion results in increased expression of TRP53 protein] [Vitamin E co-treated with Selenium] inhibits the reaction [Malathion results in increased expression of TP53 mRNA] Malathion results in increased expression of TP53 mRNA; Malathion results in increased expression of TP53 protein
CTD
PMID:12505448 PMID:12762645 PMID:18204794 PMID:19787260 PMID:21628957 PMID:32120800 More...
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Tp53i3
tumor protein p53 inducible protein 3
increases expression multiple interactions
ISO
Malathion results in increased expression of TP53I3 mRNA [Malathion co-treated with Estrogens] results in increased expression of TP53I3 mRNA
CTD
PMID:18204794
NCBI chr 6:27,818,327...27,825,753
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Tpd52l3
TPD52 like 3
decreases expression
ISO
Malathion results in decreased expression of TPD52L3 mRNA
CTD
PMID:37047231
NCBI chr 1:227,781,173...227,785,040
Ensembl chr 1:227,773,724...227,784,467
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Tpr
translocated promoter region, nuclear basket protein
increases expression
ISO
Malathion results in increased expression of TPR mRNA
CTD
PMID:32069766
NCBI chr13:62,424,312...62,487,502
Ensembl chr13:62,424,312...62,487,496
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Tram1l1
translocation associated membrane protein 1-like 1
increases expression
ISO
Malathion results in increased expression of TRAM1L1 mRNA
CTD
PMID:37047231
NCBI chr 2:212,511,130...212,513,311
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Trim35
tripartite motif-containing 35
decreases expression
ISO
Malathion results in decreased expression of TRIM35 mRNA
CTD
PMID:32069766
NCBI chr15:40,493,697...40,510,246
Ensembl chr15:40,493,755...40,510,240
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Trpc1
transient receptor potential cation channel, subfamily C, member 1
increases expression
EXP
Malathion results in increased expression of TRPC1 mRNA; Malathion results in increased expression of TRPC1 protein
CTD
PMID:22674931
NCBI chr 8:96,263,322...96,314,220
Ensembl chr 8:96,263,329...96,314,276
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Trpc4
transient receptor potential cation channel, subfamily C, member 4
increases expression decreases expression
EXP ISO
Malathion results in increased expression of TRPC4 mRNA; Malathion results in increased expression of TRPC4 protein Malathion results in decreased expression of TRPC4 mRNA
CTD
PMID:22674931 PMID:37047231
NCBI chr 2:138,307,676...138,476,856
Ensembl chr 2:138,308,084...138,476,768
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Trpc5os
TRPC5 opposite strand
increases expression
ISO
Malathion results in increased expression of TRPC5OS mRNA
CTD
PMID:37047231
NCBI chr X:108,025,172...108,044,201
Ensembl chr X:108,024,924...108,046,581
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Tshr
thyroid stimulating hormone receptor
decreases expression
EXP
Malathion results in decreased expression of TSHR protein
CTD
PMID:29143548
NCBI chr 6:110,341,585...110,475,297
Ensembl chr 6:110,341,581...110,474,538
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Ttc9
tetratricopeptide repeat domain 9
decreases expression
ISO
Malathion results in decreased expression of TTC9 mRNA
CTD
PMID:37047231
NCBI chr 6:101,333,274...101,368,110
Ensembl chr 6:101,333,141...101,368,110
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Tusc2
tumor suppressor 2, mitochondrial calcium regulator
decreases expression
ISO
Malathion results in decreased expression of TUSC2 mRNA
CTD
PMID:32069766
NCBI chr 8:108,236,838...108,240,056
Ensembl chr 8:108,236,838...108,240,056
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Twist1
twist family bHLH transcription factor 1
increases expression
ISO
Malathion results in increased expression of TWIST1 mRNA
CTD
PMID:32069766
NCBI chr 6:50,674,910...50,676,904
Ensembl chr 6:50,674,678...50,677,653
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Txnrd3
thioredoxin reductase 3
decreases expression
ISO
Malathion results in decreased expression of TXNRD3 mRNA
CTD
PMID:37047231
NCBI chr 4:122,072,548...122,112,493
Ensembl chr 4:122,072,548...122,112,491
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Tyms
thymidylate synthetase
decreases expression
ISO
Malathion results in decreased expression of TYMS mRNA
CTD
PMID:16079077
NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536
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Ubd
ubiquitin D
increases expression
ISO
Malathion results in increased expression of UBD mRNA
CTD
PMID:37047231
NCBI chr20:1,385,487...1,387,438
Ensembl chr20:1,385,864...1,408,639 Ensembl chr20:1,385,864...1,408,639
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Umodl1
uromodulin-like 1
increases expression
ISO
Malathion results in increased expression of UMODL1 mRNA
CTD
PMID:37047231
NCBI chr20:9,027,751...9,087,133
Ensembl chr20:9,025,724...9,087,146
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Usp2
ubiquitin specific peptidase 2
increases expression
ISO
Malathion results in increased expression of USP2 mRNA
CTD
PMID:37047231
NCBI chr 8:44,411,457...44,439,668
Ensembl chr 8:44,411,607...44,438,331
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Usp27x
ubiquitin specific peptidase 27, X-linked
increases expression
ISO
Malathion results in increased expression of USP27X mRNA
CTD
PMID:37047231
NCBI chr X:15,123,620...15,126,855
Ensembl chr X:15,124,596...15,125,912
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Vhl
von Hippel-Lindau tumor suppressor
decreases expression
ISO
Malathion results in decreased expression of VHL mRNA
CTD
PMID:32069766
NCBI chr 4:146,772,483...146,779,376
Ensembl chr 4:146,772,468...146,779,377
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Vpreb3
V-set pre-B cell surrogate light chain 3
increases expression
ISO
Malathion results in increased expression of VPREB3 mRNA
CTD
PMID:32069766
NCBI chr20:12,717,421...12,718,785
Ensembl chr20:12,716,779...12,719,520
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Wbp2nl
WBP2 N-terminal like
decreases expression
ISO
Malathion results in decreased expression of WBP2NL mRNA
CTD
PMID:37047231
NCBI chr 7:113,814,793...113,831,974
Ensembl chr 7:113,814,992...113,831,333
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Wfdc6a
WAP four-disulfide core domain 6A
decreases expression
ISO
Malathion results in decreased expression of WFDC6 mRNA
CTD
PMID:37047231
NCBI chr 3:153,305,336...153,309,144
Ensembl chr 3:153,305,336...153,309,144
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Wipf3
WAS/WASL interacting protein family, member 3
decreases expression
ISO
Malathion results in decreased expression of WIPF3 mRNA
CTD
PMID:37047231
NCBI chr 4:83,550,075...83,629,929
Ensembl chr 4:83,550,468...83,629,386
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Wt1
WT1 transcription factor
increases expression
ISO
Malathion results in increased expression of WT1 mRNA
CTD
PMID:32069766
NCBI chr 3:91,566,540...91,613,653
Ensembl chr 3:91,567,001...91,613,643
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Xkr4
XK related 4
decreases expression
ISO
Malathion results in decreased expression of XKR4 mRNA
CTD
PMID:37047231
NCBI chr 5:15,896,818...16,297,733
Ensembl chr 5:15,895,863...16,282,962
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Zfp42
zinc finger protein 42
decreases expression
ISO
Malathion results in decreased expression of ZFP42 mRNA
CTD
PMID:37047231
NCBI chr16:48,836,463...48,845,443
Ensembl chr16:48,836,648...48,845,401
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Zfpm2
zinc finger protein, multitype 2
increases expression
ISO
Malathion results in increased expression of ZFPM2 mRNA
CTD
PMID:37047231
NCBI chr 7:71,678,658...72,116,209
Ensembl chr 7:71,678,880...72,116,205
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Zscan5b
zinc finger and SCAN domain containing 5B
decreases expression
ISO
Malathion results in decreased expression of ZSCAN5B mRNA
CTD
PMID:37047231
NCBI chr 1:67,666,684...67,674,238
Ensembl chr 1:67,666,691...67,674,238
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Casp3
caspase 3
multiple interactions
ISO
[Glutamic Acid co-treated with malic acid co-treated with Ubiquinone] inhibits the reaction [chromium hexavalent ion results in increased activity of CASP3 protein]; [Glutamic Acid co-treated with malic acid] inhibits the reaction [chromium hexavalent ion results in increased activity of CASP3 protein]
CTD
PMID:24732427
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Idh2
isocitrate dehydrogenase (NADP(+)) 2
multiple interactions decreases abundance
ISO
Triazines inhibits the reaction [IDH2 protein mutant form results in decreased abundance of malic acid]
CTD
PMID:27469509
NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
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Mdh1
malate dehydrogenase 1
increases expression
ISO
malic acid deficiency results in increased expression of MDH1 mRNA
CTD
PMID:26811028
NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925
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Nr1h4
nuclear receptor subfamily 1, group H, member 4
multiple interactions
ISO
[[NR1H4 protein co-treated with Dietary Fats] results in increased susceptibility to caffeic acid phenethyl ester] which results in increased abundance of malic acid
CTD
PMID:28223344
NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
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Ppargc1a
PPARG coactivator 1 alpha
increases expression
ISO
malic acid results in increased expression of PPARGC1A mRNA
CTD
PMID:23056435
NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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Ces2h
carboxylesterase 2H
multiple interactions increases hydrolysis
EXP
Dexamethasone promotes the reaction [CES2 protein results in increased hydrolysis of Methylprednisolone Hemisuccinate]
CTD
PMID:15794950
NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
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Adcyap1
adenylate cyclase activating polypeptide 1
multiple interactions
EXP
Misoprostol inhibits the reaction [ADCYAP1 protein results in increased secretion of Histamine]
CTD
PMID:11164953
NCBI chr 9:113,102,632...113,122,500
Ensembl chr 9:113,103,718...113,109,773
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions
EXP
Misoprostol inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]
CTD
PMID:18602972
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Casp3
caspase 3
multiple interactions
EXP
Misoprostol inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein]
CTD
PMID:18602972
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cat
catalase
multiple interactions
EXP
Misoprostol inhibits the reaction [Cisplatin results in decreased expression of CAT protein]
CTD
PMID:21458517
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Chrm1
cholinergic receptor, muscarinic 1
multiple interactions
EXP
Misoprostol inhibits the reaction [(4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride binds to and results in increased activity of CHRM1 protein]
CTD
PMID:2459756
NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356
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Gast
gastrin
multiple interactions decreases activity
EXP
Misoprostol inhibits the reaction [GAST protein results in increased secretion of Histamine] Misoprostol results in decreased activity of GAST protein
CTD
PMID:2459756 PMID:11164953
NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496
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Il10
interleukin 10
multiple interactions
ISO
Misoprostol inhibits the reaction [[IL23A co-treated with IL1B] results in increased expression of IL10]
CTD
PMID:19273625
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il1b
interleukin 1 beta
multiple interactions
ISO
Misoprostol inhibits the reaction [[IL23A co-treated with IL1B] results in increased expression of IL10]
CTD
PMID:19273625
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il23a
interleukin 23 subunit alpha
multiple interactions increases expression
ISO
Misoprostol inhibits the reaction [[IL23A co-treated with IL1B] results in increased expression of IL10] Misoprostol results in increased expression of IL23A mRNA
CTD
PMID:19273625
NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
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Ptger1
prostaglandin E receptor 1
multiple interactions
ISO
[L-335677 binds to and results in decreased activity of PTGER1 protein] inhibits the reaction [Misoprostol results in increased susceptibility to Formaldehyde]
CTD
PMID:16360148
NCBI chr19:24,470,258...24,473,687
Ensembl chr19:24,467,532...24,473,559
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Ptger2
prostaglandin E receptor 2
multiple interactions
ISO
[6-isopropoxy-9-oxoxanthene-2-carboxylic acid binds to and results in decreased activity of PTGER2 protein] inhibits the reaction [Misoprostol results in increased susceptibility to Formaldehyde]
CTD
PMID:16360148
NCBI chr15:18,215,013...18,228,714
Ensembl chr15:18,217,285...18,228,714
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Ptger3
prostaglandin E receptor 3
multiple interactions
ISO
[L-826266 binds to and results in decreased activity of PTGER3 protein] inhibits the reaction [Misoprostol results in decreased susceptibility to Formaldehyde]
CTD
PMID:16360148
NCBI chr 2:246,606,131...246,750,970
Ensembl chr 2:246,606,183...246,684,434
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions increases expression
EXP
4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide inhibits the reaction [Misoprostol results in increased expression of PTGS2 protein]; Indomethacin inhibits the reaction [Misoprostol results in increased expression of PTGS2 protein]
CTD
PMID:12428691
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Tac1
tachykinin, precursor 1
multiple interactions
EXP
Misoprostol promotes the reaction [Kallidin results in increased secretion of TAC1 protein]
CTD
PMID:16039053
NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
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Tnf
tumor necrosis factor
multiple interactions
ISO
Misoprostol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF]
CTD
PMID:9298541
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Slc2a4
solute carrier family 2 member 4
multiple interactions
ISO
[alpha-ketoisocaproic acid co-treated with monomethyl succinate] inhibits the reaction [Palmitates results in decreased expression of SLC2A4 mRNA]
CTD
PMID:21802492
NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
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Tp53
tumor protein p53
multiple interactions
ISO
monomethyl succinate inhibits the reaction [bis((2-oxindol-3-ylimino)-2-(2-aminoethyl)pyridine-N,N')copper(II) results in increased expression of TP53 protein]
CTD
PMID:21548882
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Calca
calcitonin-related polypeptide alpha
increases expression
ISO
Nizatidine results in increased expression of CALCA protein
CTD
PMID:12495560
NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
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Tac1
tachykinin, precursor 1
increases expression
ISO
Nizatidine results in increased expression of TAC1 protein
CTD
PMID:12495560
NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
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Abca1
ATP binding cassette subfamily A member 1
increases expression
ISO
Omeprazole results in increased expression of ABCA1 mRNA
CTD
PMID:20060385
NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
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Abcb11
ATP binding cassette subfamily B member 11
decreases activity
ISO
Omeprazole results in decreased activity of ABCB11 protein
CTD
PMID:20829430
NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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Abcb1a
ATP binding cassette subfamily B member 1A
affects expression multiple interactions
EXP ISO
Omeprazole affects the expression of ABCB1A mRNA Omeprazole promotes the reaction [Cisplatin results in increased expression of ABCB1 protein] Omeprazole promotes the reaction [Cisplatin results in increased expression of ABCB1A protein]
CTD
PMID:19483382 PMID:30452898
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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Abcb4
ATP binding cassette subfamily B member 4
decreases expression
ISO
Omeprazole results in decreased expression of ABCB4 mRNA
CTD
PMID:12040753
NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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Abcc2
ATP binding cassette subfamily C member 2
multiple interactions
ISO
[Omeprazole results in increased susceptibility to Cisplatin] which results in decreased expression of ABCC2 protein
CTD
PMID:35447140
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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Abcc3
ATP binding cassette subfamily C member 3
increases expression
EXP
Omeprazole results in increased expression of ABCC3 mRNA
CTD
PMID:19118567
NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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Abcc6
ATP binding cassette subfamily C member 6
affects expression
EXP
Omeprazole affects the expression of ABCC6 mRNA
CTD
PMID:19483382
NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464
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Abcg2
ATP binding cassette subfamily G member 2
increases expression multiple interactions
ISO
Omeprazole results in increased expression of ABCG2 mRNA alternative form; Omeprazole results in increased expression of ABCG2 protein Omeprazole inhibits the reaction [ABCG2 protein results in increased transport of lucifer yellow]
CTD
PMID:20804740 PMID:31348918
NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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Abcg5
ATP binding cassette subfamily G member 5
affects expression
EXP
Omeprazole affects the expression of ABCG5 mRNA
CTD
PMID:19483382
NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563
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Abhd1
abhydrolase domain containing 1
affects expression
EXP
Omeprazole affects the expression of ABHD1 mRNA
CTD
PMID:19483382
NCBI chr 6:25,422,526...25,427,514
Ensembl chr 6:25,422,526...25,427,514
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Abhd14b
abhydrolase domain containing 14b
affects expression
EXP
Omeprazole affects the expression of ABHD14B mRNA
CTD
PMID:19483382
NCBI chr 8:107,087,157...107,092,122
Ensembl chr 8:107,088,069...107,092,119
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Abhd17a
abhydrolase domain containing 17A, depalmitoylase
affects expression
EXP
Omeprazole affects the expression of ABHD17A mRNA
CTD
PMID:19483382
NCBI chr 7:9,124,332...9,132,762
Ensembl chr 7:9,124,332...9,130,762
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Acaca
acetyl-CoA carboxylase alpha
affects expression
EXP
Omeprazole affects the expression of ACACA mRNA
CTD
PMID:19483382
NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
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Acadl
acyl-CoA dehydrogenase, long chain
affects expression
EXP
Omeprazole affects the expression of ACADL mRNA
CTD
PMID:19483382
NCBI chr 9:68,333,981...68,372,149
Ensembl chr 9:68,333,980...68,372,220
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Ace2
angiotensin converting enzyme 2
decreases expression
EXP ISO
Omeprazole results in decreased expression of ACE2 mRNA
CTD
PMID:32808185
NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
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Aco1
aconitase 1
affects expression
EXP
Omeprazole affects the expression of ACO1 mRNA
CTD
PMID:19483382
NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391
G
Aco2
aconitase 2
affects expression
EXP
Omeprazole affects the expression of ACO2 mRNA
CTD
PMID:19483382
NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261
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Acot12
acyl-CoA thioesterase 12
affects expression
EXP
Omeprazole affects the expression of ACOT12 mRNA
CTD
PMID:19483382
NCBI chr 2:22,986,867...23,027,538
Ensembl chr 2:22,986,626...23,027,536
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Acot4
acyl-CoA thioesterase 4
affects expression
EXP
Omeprazole affects the expression of ACOT4 mRNA
CTD
PMID:19483382
NCBI chr 6:103,668,699...103,674,037
Ensembl chr 6:103,668,753...103,673,917
G
Adam15
ADAM metallopeptidase domain 15
affects expression
EXP
Omeprazole affects the expression of ADAM15 mRNA
CTD
PMID:19483382
NCBI chr 2:174,754,629...174,765,136
Ensembl chr 2:174,754,633...174,765,113
G
Add1
adducin 1
affects expression
EXP
Omeprazole affects the expression of ADD1 mRNA
CTD
PMID:19483382
NCBI chr14:76,108,643...76,167,267
Ensembl chr14:76,108,654...76,167,182
G
Adh1c
alcohol dehydrogenase 1C (class I), gamma polypeptide
decreases expression
ISO
Omeprazole results in decreased expression of ADH1C mRNA
CTD
PMID:12040753
NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892
G
Adh4
alcohol dehydrogenase 4 (class II), pi polypeptide
affects expression
EXP
Omeprazole affects the expression of ADH4 mRNA
CTD
PMID:19483382
NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591
G
Adtrp
androgen-dependent TFPI-regulating protein
affects expression
EXP
Omeprazole affects the expression of ADTRP mRNA
CTD
PMID:19483382
NCBI chr17:22,907,758...22,993,834
Ensembl chr17:22,930,740...22,993,826
G
Afm
afamin
affects expression
EXP
Omeprazole affects the expression of AFM mRNA
CTD
PMID:19483382
NCBI chr14:17,531,022...17,563,868
Ensembl chr14:17,531,024...17,563,870
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Agt
angiotensinogen
affects expression
EXP
Omeprazole affects the expression of AGT mRNA
CTD
PMID:19483382
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
G
Agtr1a
angiotensin II receptor, type 1a
affects expression
EXP
Omeprazole affects the expression of AGTR1A mRNA
CTD
PMID:19483382
NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
G
Ahr
aryl hydrocarbon receptor
multiple interactions decreases activity increases activity increases expression decreases expression affects localization increases response to substance
ISO EXP
AG-879 inhibits the reaction [Omeprazole results in increased activity of AHR protein]; AHR protein affects the reaction [Omeprazole results in decreased expression of CXCR4 mRNA]; AHR protein affects the reaction [Omeprazole results in increased expression of HAMP mRNA]; AHR protein affects the susceptibility to [Omeprazole results in increased expression of CYP1A1 mRNA]; AHR protein affects the susceptibility to [Omeprazole results in increased expression of CYP1A2 mRNA]; AHR protein mutant form inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; AHR protein promotes the reaction [Omeprazole results in decreased expression of AHR mRNA]; AHR protein promotes the reaction [Omeprazole results in decreased expression of CYP1A1 mRNA]; BMX mRNA affects the reaction [Omeprazole results in increased activity of AHR protein]; Omeprazole binds to and results in increased activity of AHR protein; Omeprazole promotes the reaction [AHR protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [AHR protein binds to CYP1B1 promoter]; omeprazole sulfide inhibits the reaction [Omeprazole results in increased activity of AHR protein]; Puromycin inhibits the reaction [Omeprazole results in increased expression of AHR protein] Omeprazole results in decreased activity of AHR protein Omeprazole affects the localization of AHR protein AHR protein results in increased susceptibility to Omeprazole [Omeprazole co-treated with Diethylnitrosamine] results in increased expression of AHR mRNA; AHR protein promotes the reaction [Omeprazole results in increased expression of CYP1A1 protein]; Omeprazole affects the localization of [ARNT protein co-treated with AHR protein]
CTD
PMID:9139728 PMID:9395520 PMID:14742684 PMID:16109480 PMID:20171196 PMID:21703235 PMID:21861773 PMID:21924250 PMID:22687989 PMID:23850985 PMID:25797602 PMID:25826687 PMID:26187274 PMID:26272953 PMID:31669099 More...
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Akr1a1
aldo-keto reductase family 1 member A1
affects expression
EXP
Omeprazole affects the expression of AKR1A1 mRNA
CTD
PMID:19483382
NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674
G
Akr7a2
aldo-keto reductase family 7, member A2
affects expression
EXP
Omeprazole affects the expression of AKR7A2 mRNA
CTD
PMID:19483382
NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909
G
Akr7a3
aldo-keto reductase family 7 member A3
affects expression multiple interactions
EXP
Omeprazole affects the expression of AKR7A3 mRNA [Omeprazole co-treated with Diethylnitrosamine] results in increased expression of AKR7A3 mRNA
CTD
PMID:19483382 PMID:22687989
NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394
G
Aldh1a1
aldehyde dehydrogenase 1 family, member A1
affects expression multiple interactions
EXP
Omeprazole affects the expression of ALDH1A1 mRNA [Omeprazole co-treated with Diethylnitrosamine] results in increased expression of ALDH1A1 mRNA
CTD
PMID:19483382 PMID:22687989
NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
G
Aldh1a3
aldehyde dehydrogenase 1 family, member A3
increases expression
ISO
Omeprazole results in increased expression of ALDH1A3 mRNA
CTD
PMID:12040753
NCBI chr 1:119,982,272...120,017,416
Ensembl chr 1:119,982,277...120,017,436
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Aldh2
aldehyde dehydrogenase 2 family member
affects expression
EXP
Omeprazole affects the expression of ALDH2 mRNA
CTD
PMID:19483382
NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521
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Aldh3a1
aldehyde dehydrogenase 3 family, member A1
increases expression
ISO
Omeprazole results in increased expression of ALDH3A1 mRNA
CTD
PMID:12040753
NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681
G
Alkbh7
alkB homolog 7
affects expression
EXP
Omeprazole affects the expression of ALKBH7 mRNA
CTD
PMID:19483382
NCBI chr 9:1,838,886...1,841,044
Ensembl chr 9:1,838,811...1,841,044
G
Ankrd40
ankyrin repeat domain 40
increases expression
EXP
Omeprazole results in increased expression of TMPRSS2 mRNA
CTD
PMID:32808185
NCBI chr10:79,282,075...79,295,322
Ensembl chr10:79,282,075...79,295,320
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Ap2m1
adaptor related protein complex 2 subunit mu 1
affects expression
EXP
Omeprazole affects the expression of AP2M1 mRNA
CTD
PMID:19483382
NCBI chr11:80,355,307...80,364,218
Ensembl chr11:80,328,041...80,364,140
G
Apcs
amyloid P component, serum
affects expression
EXP
Omeprazole affects the expression of APCS mRNA
CTD
PMID:19483382
NCBI chr13:85,373,219...85,374,195
Ensembl chr13:85,373,220...85,374,298
G
Apoa4
apolipoprotein A4
affects expression
EXP
Omeprazole affects the expression of APOA4 mRNA
CTD
PMID:19483382
NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469
G
Apoh
apolipoprotein H
affects expression
EXP
Omeprazole affects the expression of APOH mRNA
CTD
PMID:19483382
NCBI chr10:93,342,435...93,356,334
Ensembl chr10:93,310,977...93,356,329
G
Apool
apolipoprotein O-like
affects expression
EXP
Omeprazole affects the expression of APOOL mRNA
CTD
PMID:19483382
NCBI chr X:77,377,723...77,443,672
Ensembl chr X:77,377,781...77,443,900
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Arg1
arginase 1
affects expression
EXP
Omeprazole affects the expression of ARG1 mRNA
CTD
PMID:19483382
NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
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Arl6ip1
ADP-ribosylation factor like GTPase 6 interacting protein 1
affects expression
EXP
Omeprazole affects the expression of ARL6IP1 mRNA
CTD
PMID:19483382
NCBI chr 1:172,430,475...172,439,990
Ensembl chr 1:172,430,489...172,439,994
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Arnt
aryl hydrocarbon receptor nuclear translocator
multiple interactions affects localization
ISO EXP
Omeprazole promotes the reaction [ARNT protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [ARNT protein binds to CYP1B1 promoter] Omeprazole affects the localization of ARNT protein Omeprazole affects the localization of [ARNT protein co-treated with AHR protein]
CTD
PMID:9395520 PMID:21703235 PMID:25826687
NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
G
Asgr2
asialoglycoprotein receptor 2
affects expression
EXP
Omeprazole affects the expression of ASGR2 mRNA
CTD
PMID:19483382
NCBI chr10:54,821,407...54,834,624
Ensembl chr10:54,821,438...54,834,617
G
Atf5
activating transcription factor 5
affects expression
EXP
Omeprazole affects the expression of ATF5 mRNA
CTD
PMID:19483382
NCBI chr 1:95,295,602...95,299,755
Ensembl chr 1:95,295,610...95,299,707
G
Atp5f1e
ATP synthase F1 subunit epsilon
affects expression
EXP
Omeprazole affects the expression of ATP5F1E mRNA
CTD
PMID:19483382
NCBI chr 3:163,259,072...163,261,974
Ensembl chr 3:163,260,476...163,261,450
G
Atp6ap2
ATPase H+ transporting accessory protein 2
affects expression
EXP
Omeprazole affects the expression of ATP6AP2 mRNA
CTD
PMID:19483382
NCBI chr X:10,183,983...10,210,948
Ensembl chr X:10,183,068...10,210,918
G
Atp6v1a
ATPase H+ transporting V1 subunit A
affects expression
EXP
Omeprazole affects the expression of ATP6V1A mRNA
CTD
PMID:19483382
NCBI chr11:56,561,444...56,614,694
Ensembl chr11:56,560,974...56,614,694
G
Atp6v1f
ATPase H+ transporting V1 subunit F
affects expression
EXP
Omeprazole affects the expression of ATP6V1F mRNA
CTD
PMID:19483382
NCBI chr 4:58,067,666...58,070,628
G
Atp7a
ATPase copper transporting alpha
multiple interactions
ISO
Omeprazole inhibits the reaction [ATP7A protein results in increased activity of TYR protein] Omeprazole inhibits the reaction [Copper affects the localization of ATP7A protein]; Omeprazole inhibits the reaction [cupric chloride affects the localization of ATP7A protein]
CTD
PMID:25337692
NCBI chr X:71,094,144...71,201,550
Ensembl chr X:71,094,202...71,198,354
G
Baat
bile acid CoA:amino acid N-acyltransferase
affects expression
EXP
Omeprazole affects the expression of BAAT mRNA
CTD
PMID:19483382
NCBI chr 5:63,851,668...63,860,641
Ensembl chr 5:63,850,705...63,860,685
G
Bax
BCL2 associated X, apoptosis regulator
multiple interactions
ISO
Omeprazole inhibits the reaction [Cisplatin results in increased expression of BAX protein]
CTD
PMID:30452898
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
G
Bcl2
BCL2, apoptosis regulator
multiple interactions
ISO
Omeprazole inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]
CTD
PMID:30452898
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
G
Bcl6b
BCL6B, transcription repressor
affects expression
EXP
Omeprazole affects the expression of BCL6B mRNA
CTD
PMID:19483382
NCBI chr10:54,940,908...54,947,022
Ensembl chr10:54,940,909...54,945,974
G
Bltp3b
bridge-like lipid transfer protein family member 3B
affects expression
EXP
Omeprazole affects the expression of BLTP3B mRNA
CTD
PMID:19483382
NCBI chr 7:24,181,635...24,261,720
Ensembl chr 7:24,181,644...24,261,720
G
Bmf
Bcl2 modifying factor
affects expression
EXP
Omeprazole affects the expression of BMF mRNA
CTD
PMID:19483382
NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145
G
Bmx
BMX non-receptor tyrosine kinase
multiple interactions
ISO
BMX mRNA affects the reaction [Omeprazole results in increased activity of AHR protein]
CTD
PMID:21861773
NCBI chr X:30,227,251...30,290,015
Ensembl chr X:30,227,251...30,289,993
G
Bnip3
BCL2 interacting protein 3
affects expression
EXP
Omeprazole affects the expression of BNIP3 mRNA
CTD
PMID:19483382
NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
G
Btf3
basic transcription factor 3
affects expression
EXP
Omeprazole affects the expression of BTF3 mRNA
CTD
PMID:19483382
NCBI chr 2:29,659,764...29,666,898
Ensembl chr 2:29,659,231...29,666,879
G
C1qa
complement C1q A chain
decreases expression
EXP
Omeprazole results in decreased expression of C1QA mRNA
CTD
PMID:25626140
NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534
G
C1qbp
complement C1q binding protein
affects expression
EXP
Omeprazole affects the expression of C1QBP mRNA
CTD
PMID:19483382
NCBI chr10:55,699,954...55,704,605
Ensembl chr10:55,699,954...55,704,649
G
C1qc
complement C1q C chain
decreases expression
EXP
Omeprazole results in decreased expression of C1QC mRNA
CTD
PMID:25626140
NCBI chr 5:149,127,412...149,130,757
Ensembl chr 5:149,127,415...149,131,017
G
C1s
complement C1s
affects expression
EXP
Omeprazole affects the expression of C1S mRNA
CTD
PMID:19483382
NCBI chr 4:157,430,249...157,442,438
Ensembl chr 4:157,430,117...157,442,303
G
C2cd2
C2 calcium-dependent domain containing 2
affects expression
EXP
Omeprazole affects the expression of C2CD2 mRNA
CTD
PMID:19483382
NCBI chr11:37,225,321...37,289,741
Ensembl chr11:37,227,415...37,289,739
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C4bpa
complement component 4 binding protein, alpha
affects expression decreases expression
EXP
Omeprazole affects the expression of C4BPA mRNA Omeprazole results in decreased expression of C4BPA mRNA
CTD
PMID:19483382 PMID:25626140
NCBI chr13:42,075,715...42,111,205
Ensembl chr13:42,075,717...42,111,205
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C4bpb
complement component 4 binding protein, beta
decreases expression
EXP
Omeprazole results in decreased expression of C4BPB mRNA
CTD
PMID:25626140
NCBI chr13:42,120,798...42,131,515
Ensembl chr13:42,120,798...42,131,817
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C7
complement C7
affects expression
EXP
Omeprazole affects the expression of C7 mRNA
CTD
PMID:19483382
NCBI chr 2:54,088,116...54,165,102
Ensembl chr 2:54,088,116...54,158,535
G
C8b
complement C8 beta chain
affects expression
EXP
Omeprazole affects the expression of C8B mRNA
CTD
PMID:19483382
NCBI chr 5:119,535,009...119,572,565
Ensembl chr 5:119,535,146...119,572,565
G
Cadps2
calcium dependent secretion activator 2
affects expression
EXP
Omeprazole affects the expression of CADPS2 mRNA
CTD
PMID:19483382
NCBI chr 4:51,780,415...52,309,641
Ensembl chr 4:51,781,053...52,309,829
G
Caprin1
cell cycle associated protein 1
affects expression
EXP
Omeprazole affects the expression of CAPRIN1 mRNA
CTD
PMID:19483382
NCBI chr 3:90,152,305...90,230,447
Ensembl chr 3:90,153,620...90,230,502
G
Car2
carbonic anhydrase 2
affects expression
EXP
Omeprazole affects the expression of CA2 mRNA
CTD
PMID:19483382
NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
G
Car3
carbonic anhydrase 3
affects expression
EXP
Omeprazole affects the expression of CAR3 mRNA
CTD
PMID:19483382
NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280
G
Casp3
caspase 3
increases activity multiple interactions affects expression increases cleavage
ISO EXP
Omeprazole analog results in increased activity of CASP3 protein; Omeprazole results in increased activity of CASP3 protein Omeprazole inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein] Omeprazole inhibits the reaction [Ethanol results in increased activity of CASP3 protein]; Omeprazole inhibits the reaction [Ethanol results in increased expression of CASP3 mRNA]; Omeprazole inhibits the reaction [Indomethacin results in increased activity of CASP3 protein] Omeprazole affects the expression of CASP3 mRNA Omeprazole results in increased cleavage of CASP3 protein
CTD
PMID:15461867 PMID:18336733 PMID:19251492 PMID:19483382 PMID:25637687 PMID:30452898 More...
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp8
caspase 8
increases cleavage
ISO
Omeprazole analog results in increased cleavage of CASP8 protein
CTD
PMID:18336733
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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Cat
catalase
increases activity multiple interactions
EXP ISO
Omeprazole results in increased activity of CAT protein Omeprazole inhibits the reaction [Ethanol results in decreased activity of CAT protein] Omeprazole inhibits the reaction [Acetic Acid results in increased activity of CAT protein]
CTD
PMID:18547560 PMID:28849987 PMID:33245926
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Cbr1
carbonyl reductase 1
affects expression
EXP
Omeprazole affects the expression of CBR1 mRNA
CTD
PMID:19483382
NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393 Ensembl chr11:32,908,950...32,911,393
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Cckbr
cholecystokinin B receptor
multiple interactions
ISO
[Omeprazole co-treated with CCKBR protein] results in increased expression of IER3
CTD
PMID:17704804
NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:159,771,733...159,814,881
G
Ccnd1
cyclin D1
decreases expression
EXP
Omeprazole results in decreased expression of CCND1 mRNA
CTD
PMID:17202759
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression
ISO
Omeprazole results in increased expression of CDKN1A protein
CTD
PMID:27358234
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cdo1
cysteine dioxygenase type 1
affects expression
EXP
Omeprazole affects the expression of CDO1 mRNA
CTD
PMID:19483382
NCBI chr18:39,432,473...39,447,253
Ensembl chr18:39,432,474...39,447,296
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Cept1
choline/ethanolamine phosphotransferase 1
affects expression
EXP
Omeprazole affects the expression of CEPT1 mRNA
CTD
PMID:19483382
NCBI chr 2:193,994,220...194,036,141
Ensembl chr 2:193,993,447...194,035,578
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Ces2h
carboxylesterase 2H
affects expression
EXP
Omeprazole affects the expression of CES2 mRNA
CTD
PMID:19483382
NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
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Cfi
complement factor I
affects expression decreases expression
EXP
Omeprazole affects the expression of CFI mRNA Omeprazole results in decreased expression of CFI mRNA
CTD
PMID:19483382 PMID:25626140
NCBI chr 2:218,389,079...218,430,565
Ensembl chr 2:218,387,990...218,430,561
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Cftr
CF transmembrane conductance regulator
affects metabolic processing
ISO
CFTR protein affects the metabolism of Omeprazole
CTD
PMID:15319328
NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756
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Chp1
calcineurin-like EF-hand protein 1
affects expression
EXP
Omeprazole affects the expression of CHP1 mRNA
CTD
PMID:19483382
NCBI chr 3:106,536,009...106,571,255
Ensembl chr 3:106,536,004...106,571,251
G
Cisd1
CDGSH iron sulfur domain 1
affects expression
EXP
Omeprazole affects the expression of CISD1 mRNA
CTD
PMID:19483382
NCBI chr20:17,255,302...17,268,688
Ensembl chr20:17,255,151...17,284,924
G
Clcn4
chloride voltage-gated channel 4
affects expression
EXP
Omeprazole affects the expression of CLCN4 mRNA
CTD
PMID:19483382
NCBI chr X:23,729,194...23,795,391
Ensembl chr X:23,729,338...23,793,238
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Clpp
caseinolytic mitochondrial matrix peptidase proteolytic subunit
affects expression
EXP
Omeprazole affects the expression of CLPP mRNA
CTD
PMID:19483382
NCBI chr 9:1,831,680...1,837,700
Ensembl chr 9:1,830,311...1,837,693
G
Clptm1l
CLPTM1-like
affects expression
EXP
Omeprazole affects the expression of CLPTM1L mRNA
CTD
PMID:19483382
NCBI chr 1:29,667,545...29,683,530
Ensembl chr 1:29,667,545...29,683,530
G
Cmbl
carboxymethylenebutenolidase homolog
affects expression
EXP
Omeprazole affects the expression of CMBL mRNA
CTD
PMID:19483382
NCBI chr 2:82,569,257...82,591,007
Ensembl chr 2:82,571,888...82,591,009
G
Cmpk1
cytidine/uridine monophosphate kinase 1
affects expression
EXP
Omeprazole affects the expression of CMPK1 mRNA
CTD
PMID:19483382
NCBI chr 5:128,480,301...128,507,830
Ensembl chr 5:128,480,301...128,507,830
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Copg1
COPI coat complex subunit gamma 1
affects expression
EXP
Omeprazole affects the expression of COPG1 mRNA
CTD
PMID:19483382
NCBI chr 4:120,366,540...120,392,502
Ensembl chr 4:120,366,542...120,415,616
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Cops4
COP9 signalosome subunit 4
affects expression
EXP
Omeprazole affects the expression of COPS4 mRNA
CTD
PMID:19483382
NCBI chr14:9,078,579...9,108,788
Ensembl chr14:9,078,576...9,108,887
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Coq3
coenzyme Q3 methyltransferase
affects expression
EXP
Omeprazole affects the expression of COQ3 mRNA
CTD
PMID:19483382
NCBI chr 5:35,429,567...35,460,613
Ensembl chr 5:35,429,574...35,460,607
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Cox4i1
cytochrome c oxidase subunit 4i1
affects expression
EXP
Omeprazole affects the expression of COX4I1 mRNA
CTD
PMID:19483382
NCBI chr19:48,721,680...48,727,920
Ensembl chr19:48,721,199...48,727,921
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Cpn1
carboxypeptidase N subunit 1
affects expression
EXP
Omeprazole affects the expression of CPN1 mRNA
CTD
PMID:19483382
NCBI chr 1:242,844,575...242,873,465
Ensembl chr 1:242,844,212...242,873,465
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Cpq
carboxypeptidase Q
affects expression
EXP
Omeprazole affects the expression of CPQ mRNA
CTD
PMID:19483382
NCBI chr 7:64,264,025...64,830,867
Ensembl chr 7:64,264,081...64,724,546
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Crem
cAMP responsive element modulator
affects expression
EXP
Omeprazole affects the expression of CREM mRNA
CTD
PMID:19483382
NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989
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Csnk2b
casein kinase 2 beta
affects expression
EXP
Omeprazole affects the expression of CSNK2B mRNA
CTD
PMID:19483382
NCBI chr20:3,700,363...3,705,331
Ensembl chr20:3,698,733...3,707,133
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Csrp1
cysteine and glycine-rich protein 1
affects expression
EXP
Omeprazole affects the expression of CSRP1 mRNA
CTD
PMID:19483382
NCBI chr13:47,158,171...47,179,388
Ensembl chr13:47,167,789...47,179,384
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Ctnna1
catenin alpha 1
affects expression
EXP
Omeprazole affects the expression of CTNNA1 mRNA
CTD
PMID:19483382
NCBI chr18:26,728,246...26,860,911
Ensembl chr18:26,728,485...26,860,910
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Ctsb
cathepsin B
decreases activity
ISO
Omeprazole results in decreased activity of CTSB protein
CTD
PMID:34871754
NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
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Ctsd
cathepsin D
multiple interactions
EXP
Omeprazole inhibits the reaction [Cysteamine results in increased expression of CTSD protein]
CTD
PMID:20165931
NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
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Ctse
cathepsin E
decreases expression
EXP
Omeprazole results in decreased expression of CTSE
CTD
PMID:7575556
NCBI chr13:43,091,954...43,114,509
Ensembl chr13:43,092,128...43,114,502
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Cxcr4
C-X-C motif chemokine receptor 4
decreases expression multiple interactions
ISO
Omeprazole results in decreased expression of CXCR4 mRNA AHR protein affects the reaction [Omeprazole results in decreased expression of CXCR4 mRNA]
CTD
PMID:25826687
NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases activity multiple interactions decreases activity increases expression
ISO EXP
Omeprazole results in increased activity of CYP1A1 promoter Omeprazole inhibits the reaction [Oxygen results in increased expression of CYP1A1 protein]; Omeprazole promotes the reaction [Oxygen results in decreased expression of CYP1A1 mRNA] Omeprazole results in decreased activity of CYP1A1 protein Omeprazole results in increased expression of CYP1A1 mRNA; Omeprazole results in increased expression of CYP1A1 protein [Omeprazole co-treated with Diethylnitrosamine] results in increased expression of CYP1A1 mRNA; AHR protein promotes the reaction [Omeprazole results in increased expression of CYP1A1 protein]; daidzein inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; daidzein inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; Genistein inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; Genistein inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; herbimycin inhibits the reaction [Omeprazole results in increased activity of CYP1A1 protein]; herbimycin inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; herbimycin inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; lavendustin A inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; Staurosporine inhibits the reaction [Omeprazole results in increased expression of CYP1A1 protein]; Tosyllysine Chloromethyl Ketone inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA] AHR protein affects the susceptibility to [Omeprazole results in increased expression of CYP1A1 mRNA]; AHR protein mutant form inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; AHR protein promotes the reaction [Omeprazole results in decreased expression of CYP1A1 mRNA]; herbimycin inhibits the reaction [Omeprazole results in increased expression of CYP1A1 mRNA]; Omeprazole promotes the reaction [AHR protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [ARNT protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [EP300 protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [NCOA1 protein binds to CYP1A1 promoter]
CTD
PMID:8647108 PMID:8900397 PMID:9041675 PMID:9139728 PMID:9152597 PMID:9395520 PMID:9860486 PMID:10103034 PMID:10859152 PMID:11454723 PMID:11849738 PMID:12040753 PMID:12623754 PMID:12841937 PMID:14742684 PMID:14987951 PMID:15681896 PMID:15860653 PMID:17202759 PMID:17954527 PMID:18420780 PMID:18502397 PMID:19118567 PMID:20171196 PMID:21666223 PMID:21703235 PMID:21784029 PMID:22687989 PMID:25626140 PMID:25826687 PMID:26187180 PMID:26272953 More...
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
increases activity increases expression decreases activity multiple interactions
ISO EXP
Omeprazole results in increased activity of CYP1A2 promoter; Omeprazole results in increased activity of CYP1A2 protein Omeprazole results in increased expression of CYP1A2 mRNA; Omeprazole results in increased expression of CYP1A2 protein Omeprazole results in decreased activity of CYP1A2 protein [Omeprazole co-treated with Diethylnitrosamine] results in increased expression of CYP1A2 mRNA [Omeprazole results in increased expression of CYP1A2 protein] which results in decreased alkylation of Phenacetin; AHR protein affects the susceptibility to [Omeprazole results in increased expression of CYP1A2 mRNA]; Omeprazole results in increased expression of and results in increased activity of CYP1A2 protein
CTD
PMID:9152597 PMID:9744552 PMID:12040753 PMID:12623754 PMID:12841937 PMID:15681896 PMID:15802389 PMID:16035375 PMID:17954527 PMID:18332078 PMID:18420780 PMID:18502397 PMID:19118567 PMID:19230594 PMID:20171196 PMID:21784029 PMID:21924250 PMID:22524704 PMID:22687989 PMID:23274770 PMID:23850985 PMID:24752503 PMID:25626140 PMID:26204831 PMID:27794450 PMID:31863871 PMID:36288780 More...
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
multiple interactions affects expression decreases activity increases expression
ISO
Omeprazole promotes the reaction [AHR protein binds to CYP1B1 promoter]; Omeprazole promotes the reaction [ARNT protein binds to CYP1B1 promoter]; Omeprazole promotes the reaction [EP300 protein binds to CYP1B1 promoter]; Omeprazole promotes the reaction [NCOA1 protein binds to CYP1B1 promoter] Omeprazole affects the expression of CYP1B1 mRNA Omeprazole results in decreased activity of CYP1B1 protein Omeprazole results in increased expression of CYP1B1 mRNA
CTD
PMID:12040753 PMID:12623754 PMID:18420780 PMID:21703235 PMID:25826687
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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Cyp2a1
cytochrome P450, family 2, subfamily a, polypeptide 1
affects expression
EXP
Omeprazole affects the expression of CYP2A1 mRNA
CTD
PMID:19483382
NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887
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Cyp2b1
cytochrome P450, family 2, subfamily b, polypeptide 1
increases expression
EXP
Omeprazole results in increased expression of CYP2B1 mRNA; Omeprazole results in increased expression of CYP2B1 protein
CTD
PMID:9152597 PMID:19118567
NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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Cyp2b2
cytochrome P450, family 2, subfamily b, polypeptide 2
increases expression affects expression
EXP
Omeprazole results in increased expression of CYP2B2 protein Omeprazole affects the expression of CYP2B2 mRNA
CTD
PMID:9152597 PMID:19483382
NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
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Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
affects expression decreases activity increases expression increases activity
EXP ISO
Omeprazole affects the expression of CYP2B3 mRNA Omeprazole results in decreased activity of CYP2B10 protein Omeprazole results in increased expression of CYP2B6 mRNA Omeprazole results in increased activity of CYP2B6 protein
CTD
PMID:17954527 PMID:18420780 PMID:19118567 PMID:19483382 PMID:22524704
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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Cyp2c11
cytochrome P450, subfamily 2, polypeptide 11
multiple interactions
ISO
Omeprazole inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Diclofenac]
CTD
PMID:15258107
NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
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Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
decreases metabolic processing decreases activity multiple interactions increases hydroxylation increases metabolic processing affects metabolic processing
ISO
CYP2C19 gene alternative form results in decreased metabolism of Omeprazole Omeprazole results in decreased activity of CYP2C19 protein [5-bromotryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-chlorotryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-fluoro-alpha-methyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-fluorotryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-methoxy-N,N-diisopropyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [5-methyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [7-methyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [Chloramphenicol results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [Fluconazole results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [indopan results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [N,N-diallyl-5-methoxytryptamine results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [N,N-diisopropyltryptamine analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; [Omeprazole results in decreased activity of CYP2C19 protein] which results in decreased chemical synthesis of 16-O-demethylaconitine metabolite; [Omeprazole results in decreased activity of CYP2C19 protein] which results in decreased chemical synthesis of Aconitine metabolite; [Tryptamines analog results in decreased activity of CYP2C19 protein] which results in decreased metabolism of Omeprazole; Omeprazole affects the reaction [CYP2C19 protein affects the metabolism of Warfarin]; Omeprazole inhibits the reaction [CYP2C19 protein results in decreased methylation of adinazolam]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased chemical synthesis of 4-hydroxymephenytoin]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased hydroxylation of Mephenytoin]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased metabolism of auriculasin]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased metabolism of Fluoxetine]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased oxidation of 2-oxo-clopidogrel]; Omeprazole inhibits the reaction [CYP2C19 protein results in increased oxidation of Clopidogrel] CYP2C19 protein results in increased hydroxylation of Omeprazole CYP2C19 protein results in increased metabolism of Omeprazole CYP2C19 protein affects the metabolism of Omeprazole
CTD
PMID:8930576 PMID:9600717 PMID:11752104 PMID:12464242 PMID:12467917 PMID:12485723 PMID:12637241 PMID:14586384 PMID:15258107 PMID:15286053 PMID:15306208 PMID:15626586 PMID:16035375 PMID:17565714 PMID:17702393 PMID:18511451 PMID:18520598 PMID:19812348 PMID:20573087 PMID:21277363 PMID:21795468 PMID:21915887 PMID:22634058 PMID:26599973 PMID:31515991 More...
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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Cyp2d3
cytochrome P450, family 2, subfamily d, polypeptide 3
affects expression
EXP
Omeprazole affects the expression of CYP2D3 mRNA
CTD
PMID:19483382
NCBI chr 7:113,917,711...113,922,068
Ensembl chr 7:113,908,947...113,922,084
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Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
affects expression decreases activity
EXP ISO
Omeprazole affects the expression of CYP2D4 mRNA Omeprazole results in decreased activity of CYP2D6 protein
CTD
PMID:18420780 PMID:19483382
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
multiple interactions
ISO
Omeprazole results in increased expression of and results in increased activity of CYP2E1 protein
CTD
PMID:15802389 PMID:36243147
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Cyp2f4
cytochrome P450, family 2, subfamily f, polypeptide 4
affects expression
EXP
Omeprazole affects the expression of CYP2F4 mRNA
CTD
PMID:19483382
NCBI chr 1:82,416,107...82,429,897
Ensembl chr 1:82,416,130...82,429,896
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Cyp2j4
cytochrome P450, family 2, subfamily j, polypeptide 4
affects expression
EXP
Omeprazole affects the expression of CYP2J4 mRNA
CTD
PMID:19483382
NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794
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Cyp2t1
cytochrome P450, family 2, subfamily t, polypeptide 1
affects expression
EXP
Omeprazole affects the expression of CYP2T1 mRNA
CTD
PMID:19483382
NCBI chr 1:82,446,321...82,451,564
Ensembl chr 1:82,446,921...82,451,563
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
affects metabolic processing increases metabolic processing multiple interactions increases expression
ISO
CYP3A4 protein affects the metabolism of Omeprazole CYP3A4 protein results in increased metabolism of Omeprazole [Omeprazole results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; NR1I2 protein affects the reaction [Omeprazole results in increased expression of CYP3A4 mRNA]; Omeprazole inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]; Omeprazole results in increased expression of and results in increased activity of CYP3A4 protein Omeprazole results in increased expression of CYP3A4 mRNA; Omeprazole results in increased expression of CYP3A4 protein
CTD
PMID:7870052 PMID:8930576 PMID:9744552 PMID:12235278 PMID:12485723 PMID:12695340 PMID:15286053 PMID:15466163 PMID:15626586 PMID:15802389 PMID:17041008 PMID:17565714 PMID:17954527 PMID:19118567 PMID:19299527 PMID:22634058 More...
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Cyp3a23-3a1
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1
affects expression increases expression
EXP
Omeprazole affects the expression of CYP3A23-3A1 mRNA Omeprazole results in increased expression of CYP3A23-3A1 mRNA
CTD
PMID:19118567 PMID:19483382
NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
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Cyp3a9
cytochrome P450, family 3, subfamily a, polypeptide 9
affects expression increases expression
EXP ISO
Omeprazole affects the expression of CYP3A9 mRNA Omeprazole results in increased expression of CYP3A5 mRNA
CTD
PMID:19118567 PMID:19483382
NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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Cyp4a8
cytochrome P450, family 4, subfamily a, polypeptide 8
affects expression
EXP
Omeprazole affects the expression of CYP4A8 mRNA
CTD
PMID:19483382
NCBI chr 5:128,702,130...128,733,476
Ensembl chr 5:128,702,131...128,733,476
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Cyp4f6
cytochrome P450, family 4, subfamily f, polypeptide 6
affects expression
EXP
Omeprazole affects the expression of CYP4F6 mRNA
CTD
PMID:19483382
NCBI chr 7:12,030,276...12,058,020
Ensembl chr 7:12,030,301...12,057,782
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Dbi
diazepam binding inhibitor
affects expression
EXP
Omeprazole affects the expression of DBI mRNA
CTD
PMID:19483382
NCBI chr13:31,241,466...31,249,853
Ensembl chr13:31,206,988...31,268,693
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Dcaf11
DDB1 and CUL4 associated factor 11
affects expression
EXP
Omeprazole affects the expression of DCAF11 mRNA
CTD
PMID:19483382
NCBI chr15:29,046,744...29,057,450
Ensembl chr15:29,046,826...29,057,669
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Dcxr
dicarbonyl and L-xylulose reductase
affects expression
EXP
Omeprazole affects the expression of DCXR mRNA
CTD
PMID:19483382
NCBI chr10:106,006,404...106,008,293
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Ddit3
DNA-damage inducible transcript 3
increases expression
ISO
Omeprazole results in increased expression of DDIT3 protein
CTD
PMID:27358234
NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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Decr1
2,4-dienoyl-CoA reductase 1
affects expression
EXP
Omeprazole affects the expression of DECR1 mRNA
CTD
PMID:19483382
NCBI chr 5:29,411,172...29,439,054
Ensembl chr 5:29,411,172...29,439,018
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Dexi
Dexi homolog
affects expression
EXP
Omeprazole affects the expression of DEXI mRNA
CTD
PMID:19483382
NCBI chr10:5,126,021...5,138,746
Ensembl chr10:5,137,288...5,138,738
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Dgat1
diacylglycerol O-acyltransferase 1
affects expression
EXP
Omeprazole affects the expression of DGAT1 mRNA
CTD
PMID:19483382
NCBI chr 7:108,223,860...108,235,413
Ensembl chr 7:108,218,524...108,234,299
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Dhcr24
24-dehydrocholesterol reductase
affects expression
EXP
Omeprazole affects the expression of DHCR24 mRNA
CTD
PMID:19483382
NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137
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Dhrs4
dehydrogenase/reductase 4
affects expression
EXP
Omeprazole affects the expression of DHRS4 mRNA
CTD
PMID:19483382
NCBI chr15:28,966,544...28,978,135
Ensembl chr15:28,966,553...28,978,127
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Dhrs7b
dehydrogenase/reductase 7B
affects expression
EXP
Omeprazole affects the expression of DHRS7B mRNA
CTD
PMID:19483382
NCBI chr10:45,504,344...45,537,094
Ensembl chr10:45,504,426...45,537,076
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Dhx16
DEAH-box helicase 16
affects expression
EXP
Omeprazole affects the expression of DHX16 mRNA
CTD
PMID:19483382
NCBI chr20:2,862,000...2,874,991
Ensembl chr20:2,862,000...2,874,948
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Dmac2l
distal membrane arm assembly component 2 like
affects expression
EXP
Omeprazole affects the expression of DMAC2L mRNA
CTD
PMID:19483382
NCBI chr 6:88,205,580...88,223,934
Ensembl chr 6:88,205,700...88,223,933
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Dnajc3
DnaJ heat shock protein family (Hsp40) member C3
affects expression
EXP
Omeprazole affects the expression of DNAJC3 mRNA
CTD
PMID:19483382
NCBI chr15:96,025,605...96,068,585
Ensembl chr15:96,025,624...96,065,181
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Dpp4
dipeptidylpeptidase 4
affects expression
EXP
Omeprazole affects the expression of DPP4 mRNA
CTD
PMID:19483382
NCBI chr 3:46,962,233...47,043,870
Ensembl chr 3:46,962,243...47,043,901
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Dpyd
dihydropyrimidine dehydrogenase
affects expression
EXP
Omeprazole affects the expression of DPYD mRNA
CTD
PMID:19483382
NCBI chr 2:206,609,043...207,474,982
Ensembl chr 2:206,609,122...207,474,982
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Ears2
glutamyl-tRNA synthetase 2, mitochondrial
affects expression
EXP
Omeprazole affects the expression of EARS2 mRNA
CTD
PMID:19483382
NCBI chr 1:176,597,986...176,625,848
Ensembl chr 1:176,597,986...176,625,836
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Echs1
enoyl-CoA hydratase, short chain 1
affects expression
EXP
Omeprazole affects the expression of ECHS1 mRNA
CTD
PMID:19483382
NCBI chr 1:194,895,036...194,903,863
Ensembl chr 1:194,895,036...194,903,884
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Eci1
enoyl-CoA delta isomerase 1
affects expression
EXP
Omeprazole affects the expression of ECI1 mRNA
CTD
PMID:19483382
NCBI chr10:13,456,715...13,470,061
Ensembl chr10:13,456,563...13,470,061
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Eci2
enoyl-CoA delta isomerase 2
affects expression
EXP
Omeprazole affects the expression of ECI2 mRNA
CTD
PMID:19483382
NCBI chr17:29,850,884...29,886,781
Ensembl chr17:29,870,391...29,886,781
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Eef1g
eukaryotic translation elongation factor 1 gamma
affects expression
EXP
Omeprazole affects the expression of EEF1G mRNA
CTD
PMID:19483382
NCBI chr 1:205,860,713...205,871,319
Ensembl chr 1:205,860,698...205,872,382
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Egf
epidermal growth factor
multiple interactions
ISO
Omeprazole promotes the reaction [Indomethacin results in increased expression of EGF protein]
CTD
PMID:18431645
NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064
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Ehhadh
enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
affects expression
EXP
Omeprazole affects the expression of EHHADH mRNA
CTD
PMID:19483382
NCBI chr11:79,241,927...79,275,173
Ensembl chr11:79,241,938...79,275,188
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Eif4a2
eukaryotic translation initiation factor 4A2
affects expression
EXP
Omeprazole affects the expression of EIF4A2 mRNA
CTD
PMID:19483382
NCBI chr11:77,764,126...77,770,810
Ensembl chr11:77,764,124...77,770,781
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Eif4ebp1
eukaryotic translation initiation factor 4E binding protein 1
affects expression
EXP
Omeprazole affects the expression of EIF4EBP1 mRNA
CTD
PMID:19483382
NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
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Eif4h
eukaryotic translation initiation factor 4H
affects expression
EXP
Omeprazole affects the expression of EIF4H mRNA
CTD
PMID:19483382
NCBI chr12:22,083,155...22,099,876
Ensembl chr12:22,082,835...22,099,876
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Enc1
ectodermal-neural cortex 1
affects expression
EXP
Omeprazole affects the expression of ENC1 mRNA
CTD
PMID:19483382
NCBI chr 2:28,550,670...28,562,591
Ensembl chr 2:28,550,464...28,562,713
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Eno1
enolase 1
affects expression
EXP
Omeprazole affects the expression of ENO1 mRNA
CTD
PMID:19483382
NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336
G
Enpep
glutamyl aminopeptidase
affects expression
EXP
Omeprazole affects the expression of ENPEP mRNA
CTD
PMID:19483382
NCBI chr 2:217,781,985...217,851,947
Ensembl chr 2:217,782,005...217,851,947
G
Enpp1
ectonucleotide pyrophosphatase/phosphodiesterase 1
affects expression
EXP
Omeprazole affects the expression of ENPP1 mRNA
CTD
PMID:19483382
NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715
G
Ep300
E1A binding protein p300
multiple interactions
ISO
Omeprazole promotes the reaction [EP300 protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [EP300 protein binds to CYP1B1 promoter]
CTD
PMID:21703235
NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088 Ensembl chr 7:113,106,247...113,136,088
G
Epcam
epithelial cell adhesion molecule
affects expression
EXP
Omeprazole affects the expression of EPCAM mRNA
CTD
PMID:19483382
NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127
G
Erp29
endoplasmic reticulum protein 29
affects expression
EXP
Omeprazole affects the expression of ERP29 mRNA
CTD
PMID:19483382
NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376
G
Esd
esterase D
affects expression
EXP
Omeprazole affects the expression of ESD mRNA
CTD
PMID:19483382
NCBI chr15:50,043,634...50,063,134
Ensembl chr15:50,043,632...50,063,144
G
Etfb
electron transfer flavoprotein subunit beta
affects expression
EXP
Omeprazole affects the expression of ETFB mRNA
CTD
PMID:19483382
NCBI chr 1:93,851,908...93,866,072
Ensembl chr 1:93,851,858...93,866,068
G
Faah
fatty acid amide hydrolase
affects expression
EXP
Omeprazole affects the expression of FAAH mRNA
CTD
PMID:19483382
NCBI chr 5:129,479,774...129,499,018
Ensembl chr 5:129,479,824...129,498,677
G
Fads2
fatty acid desaturase 2
affects expression
EXP
Omeprazole affects the expression of FADS2 mRNA
CTD
PMID:19483382
NCBI chr 1:206,707,384...206,747,333
Ensembl chr 1:206,708,783...206,748,789
G
Fbp1
fructose-bisphosphatase 1
affects expression
EXP
Omeprazole affects the expression of FBP1 mRNA
CTD
PMID:19483382
NCBI chr17:2,207,271...2,230,076
Ensembl chr17:2,208,031...2,230,071
G
Fdft1
farnesyl diphosphate farnesyl transferase 1
affects expression
EXP
Omeprazole affects the expression of FDFT1 mRNA
CTD
PMID:19483382
NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287
G
Fdps
farnesyl diphosphate synthase
affects expression
EXP
Omeprazole affects the expression of FDPS mRNA
CTD
PMID:19483382
NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776
G
Fdx2
ferredoxin 2
affects expression
EXP
Omeprazole affects the expression of FDX2 mRNA
CTD
PMID:19483382
NCBI chr 8:19,604,916...19,609,832
Ensembl chr 8:19,604,916...19,609,849
G
Fmo1
flavin containing dimethylaniline monoxygenase 1
affects expression
EXP
Omeprazole affects the expression of FMO1 mRNA
CTD
PMID:19483382
NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647
G
Gamt
guanidinoacetate N-methyltransferase
affects expression
EXP
Omeprazole affects the expression of GAMT mRNA
CTD
PMID:19483382
NCBI chr 7:9,448,590...9,451,413
Ensembl chr 7:9,448,628...9,451,778
G
Gapdh
glyceraldehyde-3-phosphate dehydrogenase
affects expression
EXP
Omeprazole affects the expression of GAPDH mRNA
CTD
PMID:19483382
NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
G
Gast
gastrin
increases expression
ISO EXP
Omeprazole results in increased expression of GAST protein
CTD
PMID:11422300 PMID:12189558 PMID:12763636 PMID:15223672 PMID:16618411 PMID:17652263 More...
NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496
G
Gbe1
1,4-alpha-glucan branching enzyme 1
affects expression
EXP
Omeprazole affects the expression of GBE1 mRNA
CTD
PMID:19483382
NCBI chr11:8,734,806...9,000,226
Ensembl chr11:8,734,820...9,000,210
G
Gchfr
GTP cyclohydrolase I feedback regulator
affects expression
EXP
Omeprazole affects the expression of GCHFR mRNA
CTD
PMID:19483382
NCBI chr 3:106,158,046...106,162,080
Ensembl chr 3:106,159,394...106,162,080
G
Ggh
gamma-glutamyl hydrolase
affects expression
EXP
Omeprazole affects the expression of GGH mRNA
CTD
PMID:19483382
NCBI chr 5:33,529,880...33,552,790
Ensembl chr 5:33,529,880...33,552,787
G
Ggt1
gamma-glutamyltransferase 1
multiple interactions
EXP
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of GGT1 mRNA
CTD
PMID:22687989
NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
G
Gjb1
gap junction protein, beta 1
affects expression
EXP
Omeprazole affects the expression of GJB1 mRNA
CTD
PMID:19483382
NCBI chr X:66,501,848...66,509,783
Ensembl chr X:66,501,820...66,509,925
G
Gpld1
glycosylphosphatidylinositol specific phospholipase D1
affects expression
EXP
Omeprazole affects the expression of GPLD1 mRNA
CTD
PMID:19483382
NCBI chr17:40,084,427...40,132,035
Ensembl chr17:40,084,617...40,126,939
G
Gpx1
glutathione peroxidase 1
affects expression
EXP
Omeprazole affects the expression of GPX1 mRNA
CTD
PMID:19483382
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
G
Gpx2
glutathione peroxidase 2
multiple interactions
EXP
[Omeprazole co-treated with Diethylnitrosamine] results in increased expression of GPX2 mRNA
CTD
PMID:22687989
NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
G
Gpx4
glutathione peroxidase 4
affects expression
EXP
Omeprazole affects the expression of GPX4 mRNA
CTD
PMID:19483382
NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
G
Grina
glutamate ionotropic receptor NMDA type subunit associated protein 1
affects expression
EXP
Omeprazole affects the expression of GRINA mRNA
CTD
PMID:19483382
NCBI chr 7:107,962,194...107,965,372
Ensembl chr 7:107,962,207...107,965,366
G
Grpel1
GrpE-like 1, mitochondrial
affects expression
EXP
Omeprazole affects the expression of GRPEL1 mRNA
CTD
PMID:19483382
NCBI chr14:74,292,023...74,298,243
Ensembl chr14:74,292,023...74,298,200
G
Gsta5
glutathione S-transferase alpha 5
increases expression multiple interactions
EXP
Omeprazole results in increased expression of GSTA5 mRNA [Omeprazole co-treated with Diethylnitrosamine] results in increased expression of GSTA5 mRNA
CTD
PMID:17202759 PMID:22687989
NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
G
Gstp1
glutathione S-transferase pi 1
increases expression
EXP
Omeprazole results in increased expression of GSTP1 mRNA
CTD
PMID:19118567
NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
G
Gstt1
glutathione S-transferase theta 1
affects expression
EXP
Omeprazole affects the expression of GSTT1 mRNA
CTD
PMID:19483382
NCBI chr20:12,856,613...12,873,586
Ensembl chr20:12,856,669...12,873,585
G
Gtf2h5
general transcription factor IIH subunit 5
affects expression
EXP
Omeprazole affects the expression of GTF2H5 mRNA
CTD
PMID:19483382
NCBI chr 1:46,656,804...46,663,512
Ensembl chr 1:46,656,859...46,664,939
G
Gzma
granzyme A
affects expression
EXP
Omeprazole affects the expression of GZMA mRNA
CTD
PMID:19483382
NCBI chr 2:44,740,569...44,752,502
Ensembl chr 2:44,740,569...44,752,493
G
H3f3b
H3.3 histone B
affects expression
EXP
Omeprazole affects the expression of H3F3B mRNA
CTD
PMID:19483382
NCBI chr10:101,256,484...101,258,716
Ensembl chr10:101,256,480...101,258,709
G
Hal
histidine ammonia lyase
affects expression
EXP
Omeprazole affects the expression of HAL mRNA
CTD
PMID:19483382
NCBI chr 7:28,007,449...28,037,701
Ensembl chr 7:28,006,972...28,037,701
G
Hamp
hepcidin antimicrobial peptide
increases expression multiple interactions increases secretion
ISO
Omeprazole results in increased expression of HAMP mRNA 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Omeprazole results in increased expression of HAMP mRNA]; AHR protein affects the reaction [Omeprazole results in increased expression of HAMP mRNA] Omeprazole results in increased expression of HAMP mRNA; Omeprazole results in increased expression of HAMP protein Omeprazole results in increased secretion of HAMP protein
CTD
PMID:31669099
NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
G
Hao2
hydroxyacid oxidase 2
affects expression
EXP
Omeprazole affects the expression of HAO2 mRNA
CTD
PMID:19483382
NCBI chr 2:186,200,137...186,232,997
Ensembl chr 2:186,200,504...186,224,425
G
Hba-a2
hemoglobin alpha, adult chain 2
affects expression
EXP
Omeprazole affects the expression of HBA-A2 mRNA
CTD
PMID:19483382
NCBI chr10:15,323,830...15,324,677
Ensembl chr10:15,307,815...15,338,392
G
Hbb
hemoglobin subunit beta
affects expression
EXP
Omeprazole affects the expression of HBB mRNA
CTD
PMID:19483382
NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012
G
Hdc
histidine decarboxylase
affects expression increases stability increases expression multiple interactions
EXP
Omeprazole affects the expression of HDC mRNA Omeprazole results in increased stability of HDC protein Omeprazole results in increased expression of HDC mRNA Omeprazole results in increased expression of and results in increased activity of HDC protein
CTD
PMID:12763636 PMID:19483382
NCBI chr 3:113,847,256...113,865,334
Ensembl chr 3:113,847,260...113,865,341
G
Hgd
homogentisate 1, 2-dioxygenase
affects expression
EXP
Omeprazole affects the expression of HGD mRNA
CTD
PMID:19483382
NCBI chr11:63,086,750...63,138,325
Ensembl chr11:63,086,752...63,138,323
G
Hmgn1
high mobility group nucleosome binding domain 1
affects expression
EXP
Omeprazole affects the expression of HMGN1 mRNA
CTD
PMID:19483382
NCBI chr11:35,422,328...35,428,247
Ensembl chr11:35,422,328...35,428,254
G
Hmox1
heme oxygenase 1
multiple interactions increases expression
ISO
Acetylcysteine promotes the reaction [Omeprazole results in increased expression of HMOX1 mRNA]; Acetylcysteine promotes the reaction [Omeprazole results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [Omeprazole results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [Omeprazole results in increased expression of HMOX1 protein]; Omeprazole results in increased expression of and results in increased activity of HMOX1 protein Omeprazole results in increased expression of HMOX1 mRNA; Omeprazole results in increased expression of HMOX1 protein
CTD
PMID:16712795 PMID:27725188
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
G
Hprt1
hypoxanthine phosphoribosyltransferase 1
affects expression
EXP
Omeprazole affects the expression of HPRT1 mRNA
CTD
PMID:19483382
NCBI chr X:132,736,175...132,768,149
Ensembl chr X:132,736,096...132,768,154
G
Hps5
HPS5, biogenesis of lysosomal organelles complex 2 subunit 2
affects expression
EXP
Omeprazole affects the expression of HPS5 mRNA
CTD
PMID:19483382
NCBI chr 1:97,281,626...97,320,945
Ensembl chr 1:97,247,598...97,321,019
G
Hsd17b4
hydroxysteroid (17-beta) dehydrogenase 4
affects expression
EXP
Omeprazole affects the expression of HSD17B4 mRNA
CTD
PMID:19483382
NCBI chr18:43,328,903...43,417,950
Ensembl chr18:43,328,824...43,417,952
G
Hsdl2
hydroxysteroid dehydrogenase like 2
affects expression
EXP
Omeprazole affects the expression of HSDL2 mRNA
CTD
PMID:19483382
NCBI chr 5:74,443,933...74,479,104
Ensembl chr 5:74,443,872...74,479,839
G
Hspa1a
heat shock protein family A (Hsp70) member 1A
decreases expression multiple interactions
EXP
Omeprazole results in decreased expression of HSPA1A mRNA; Omeprazole results in decreased expression of HSPA1A protein Zinc Compounds analog inhibits the reaction [Omeprazole results in decreased expression of HSPA1A protein]; Zinc Sulfate inhibits the reaction [Omeprazole results in decreased expression of HSPA1A protein]
CTD
PMID:15223672 PMID:16945336
NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
G
Hspa1l
heat shock protein family A (Hsp70) member 1 like
multiple interactions
EXP
Omeprazole inhibits the reaction [Ethanol results in increased expression of HSPA1L mRNA]
CTD
PMID:25637687
NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571
G
Htra1
HtrA serine peptidase 1
affects expression
EXP
Omeprazole affects the expression of HTRA1 mRNA
CTD
PMID:19483382
NCBI chr 1:185,497,815...185,547,380
Ensembl chr 1:185,497,735...185,547,379
G
Ier3
immediate early response 3
multiple interactions
ISO
[Omeprazole co-treated with CCKBR protein] results in increased expression of IER3
CTD
PMID:17704804
NCBI chr20:2,928,378...2,929,582
Ensembl chr20:2,928,378...2,929,583
G
Ifng
interferon gamma
multiple interactions
ISO
Omeprazole inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein]
CTD
PMID:19232345
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
G
Igf1
insulin-like growth factor 1
affects expression
EXP
Omeprazole affects the expression of IGF1 mRNA
CTD
PMID:19483382
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
G
Igfals
insulin-like growth factor binding protein, acid labile subunit
affects expression
EXP
Omeprazole affects the expression of IGFALS mRNA
CTD
PMID:19483382
NCBI chr10:13,897,468...13,903,920
Ensembl chr10:13,898,395...13,902,677
G
Igfbp2
insulin-like growth factor binding protein 2
affects expression
EXP
Omeprazole affects the expression of IGFBP2 mRNA
CTD
PMID:19483382
NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937
G
Il10
interleukin 10
multiple interactions
ISO
Omeprazole inhibits the reaction [Ethanol results in decreased expression of IL10 protein]
CTD
PMID:26970604
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
G
Il1b
interleukin 1 beta
multiple interactions
EXP
Omeprazole inhibits the reaction [Cisplatin results in increased expression of IL1B protein]
CTD
PMID:32418911
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
G
Il6
interleukin 6
multiple interactions
EXP
Omeprazole inhibits the reaction [Cisplatin results in increased expression of IL6 protein]; Omeprazole inhibits the reaction [Ethanol results in decreased expression of IL6 protein]
CTD
PMID:25637687 PMID:32418911
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
G
Impa1
inositol monophosphatase 1
affects expression
EXP
Omeprazole affects the expression of IMPA1 mRNA
CTD
PMID:19483382
NCBI chr 2:91,462,781...91,484,057
Ensembl chr 2:91,462,799...91,484,313
G
Inhbe
inhibin subunit beta E
affects expression
EXP
Omeprazole affects the expression of INHBE mRNA
CTD
PMID:19483382
NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172
G
Isyna1
inositol-3-phosphate synthase 1
affects expression
EXP
Omeprazole affects the expression of ISYNA1 mRNA
CTD
PMID:19483382
NCBI chr16:18,839,143...18,841,979
Ensembl chr16:18,839,145...18,841,979
G
Itih4
inter-alpha-trypsin inhibitor heavy chain 4
affects expression
EXP
Omeprazole affects the expression of ITIH4 mRNA
CTD
PMID:19483382
NCBI chr16:6,080,539...6,095,710
Ensembl chr16:6,080,539...6,095,708
G
Jak1
Janus kinase 1
affects expression
EXP
Omeprazole affects the expression of JAK1 mRNA
CTD
PMID:19483382
NCBI chr 5:115,780,248...115,888,841
Ensembl chr 5:115,780,248...115,888,926
G
Kdelr2
KDEL endoplasmic reticulum protein retention receptor 2
affects expression
EXP
Omeprazole affects the expression of KDELR2 mRNA
CTD
PMID:19483382
NCBI chr12:11,138,820...11,157,117
Ensembl chr12:11,138,820...11,157,153
G
Kdr
kinase insert domain receptor
affects expression multiple interactions
EXP ISO
Omeprazole affects the expression of KDR mRNA Omeprazole promotes the reaction [Oxygen results in decreased expression of KDR protein]
CTD
PMID:19483382 PMID:26272953
NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
G
Krt8
keratin 8
affects expression
EXP
Omeprazole affects the expression of KRT8 mRNA
CTD
PMID:19483382
NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728
G
Lcat
lecithin cholesterol acyltransferase
affects expression
EXP
Omeprazole affects the expression of LCAT mRNA
CTD
PMID:19483382
NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231
G
Lcmt1
leucine carboxyl methyltransferase 1
affects expression
EXP
Omeprazole affects the expression of LCMT1 mRNA
CTD
PMID:19483382
NCBI chr 1:177,904,119...177,960,111
Ensembl chr 1:177,904,139...177,960,112
G
Lipc
lipase C, hepatic type
affects expression
EXP
Omeprazole affects the expression of LIPC mRNA
CTD
PMID:19483382
NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464
G
Lox
lysyl oxidase
affects expression
EXP
Omeprazole affects the expression of LOX mRNA
CTD
PMID:19483382
NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477
G
Lrp3
LDL receptor related protein 3
affects expression
EXP
Omeprazole affects the expression of LRP3 mRNA
CTD
PMID:19483382
NCBI chr 1:87,843,815...87,859,147
Ensembl chr 1:87,844,868...87,859,110
G
Man2b1
mannosidase, alpha, class 2B, member 1
affects expression
EXP
Omeprazole affects the expression of MAN2B1 mRNA
CTD
PMID:19483382
NCBI chr19:23,055,092...23,074,398
Ensembl chr19:23,055,097...23,074,389
G
Map2k2
mitogen activated protein kinase kinase 2
affects expression
EXP
Omeprazole affects the expression of MAP2K2 mRNA
CTD
PMID:19483382
NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
G
Mapk14
mitogen activated protein kinase 14
multiple interactions
ISO
Omeprazole inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of MAPK14 protein]
CTD
PMID:17406807
NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
G
Masp2
MBL associated serine protease 2
affects expression
EXP
Omeprazole affects the expression of MASP2 mRNA
CTD
PMID:19483382
NCBI chr 5:159,035,892...159,049,561
Ensembl chr 5:159,035,911...159,049,580
G
Me1
malic enzyme 1
affects expression multiple interactions
EXP
Omeprazole affects the expression of ME1 mRNA [Omeprazole co-treated with Diethylnitrosamine] results in increased expression of ME1 mRNA
CTD
PMID:19483382 PMID:22687989
NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
G
Mmp14
matrix metallopeptidase 14
multiple interactions
EXP
Omeprazole inhibits the reaction [Indomethacin results in decreased expression of MMP14 protein]
CTD
PMID:16934674
NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864
G
Mmp2
matrix metallopeptidase 2
multiple interactions
EXP
Omeprazole inhibits the reaction [Hydrogen Peroxide results in decreased activity of MMP2 protein]
CTD
PMID:16934674
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
G
Mmut
methylmalonyl-CoA mutase
affects expression
EXP
Omeprazole affects the expression of MMUT mRNA
CTD
PMID:19483382
NCBI chr 9:19,928,720...19,956,985
Ensembl chr 9:19,928,727...19,957,046
G
Mpo
myeloperoxidase
multiple interactions decreases activity
ISO EXP
Omeprazole inhibits the reaction [[Ethanol co-treated with Hydrochloric Acid] results in increased activity of MPO protein]; Omeprazole inhibits the reaction [Acids results in increased activity of MPO protein] Omeprazole results in decreased activity of MPO protein Omeprazole inhibits the reaction [Acetic Acid results in increased activity of MPO protein]; Omeprazole inhibits the reaction [Cysteamine results in increased expression of MPO protein]; Omeprazole inhibits the reaction [Ethanol results in increased activity of MPO protein]; Omeprazole inhibits the reaction [Indomethacin results in increased activity of MPO protein]
CTD
PMID:16091555 PMID:17151854 PMID:20165931 PMID:25637687 PMID:27780710 PMID:29770154 PMID:31095933 PMID:33245926 More...
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
G
Mro
maestro
affects expression
EXP
Omeprazole affects the expression of MRO mRNA
CTD
PMID:19483382
NCBI chr18:67,450,186...67,467,593
Ensembl chr18:67,450,595...67,467,044
G
Mrpl2
mitochondrial ribosomal protein L2
affects expression
EXP
Omeprazole affects the expression of MRPL2 mRNA
CTD
PMID:19483382
NCBI chr 9:14,333,233...14,337,006
Ensembl chr 9:14,333,234...14,337,040
G
mrpl9
mitochondrial ribosomal protein L9
affects expression
EXP
Omeprazole affects the expression of MRPL9 mRNA
CTD
PMID:19483382
NCBI chr 2:182,082,012...182,086,758
Ensembl chr 2:182,076,369...182,087,095
G
Mug2
murinoglobulin 2
affects expression
EXP
Omeprazole affects the expression of PZP mRNA
CTD
PMID:19483382
NCBI chr 4:155,164,061...155,236,894
Ensembl chr 4:155,164,011...155,236,475
G
Myadm
myeloid-associated differentiation marker
affects expression
EXP
Omeprazole affects the expression of MYADM mRNA
CTD
PMID:19483382
NCBI chr 1:65,864,180...65,874,701
Ensembl chr 1:65,864,173...65,874,035
G
Mycbp2
MYC binding protein 2
affects expression
EXP
Omeprazole affects the expression of MYCBP2 mRNA
CTD
PMID:19483382
NCBI chr15:79,937,354...80,175,432
Ensembl chr15:79,937,354...80,175,498
G
Myo1d
myosin ID
affects expression
EXP
Omeprazole affects the expression of MYO1D mRNA
CTD
PMID:19483382
NCBI chr10:65,489,153...65,765,812
Ensembl chr10:65,489,154...65,766,349
G
Naa38
N(alpha)-acetyltransferase 38, NatC auxiliary subunit
affects expression
EXP
Omeprazole affects the expression of NAA38 mRNA
CTD
PMID:19483382
NCBI chr10:54,117,754...54,118,913
Ensembl chr10:54,117,163...54,119,494
G
Nap1l1
nucleosome assembly protein 1-like 1
affects expression
EXP
Omeprazole affects the expression of NAP1L1 mRNA
CTD
PMID:19483382
NCBI chr 7:46,933,278...46,957,853
Ensembl chr 7:46,933,356...46,956,593
G
Nat8
N-acetyltransferase 8
affects expression
EXP
Omeprazole affects the expression of NAT8 mRNA
CTD
PMID:19483382
NCBI chr 4:118,279,521...118,284,671
Ensembl chr 4:118,270,954...118,281,763
G
Ncoa1
nuclear receptor coactivator 1
multiple interactions
ISO
Omeprazole promotes the reaction [NCOA1 protein binds to CYP1A1 promoter]; Omeprazole promotes the reaction [NCOA1 protein binds to CYP1B1 promoter]
CTD
PMID:21703235
NCBI chr 6:27,232,609...27,507,992
Ensembl chr 6:27,232,611...27,475,664
G
Ndrg2
NDRG family member 2
affects expression
EXP
Omeprazole affects the expression of NDRG2 mRNA
CTD
PMID:19483382
NCBI chr15:24,600,981...24,609,621
Ensembl chr15:24,600,982...24,609,626
G
Ndufs5
NADH:ubiquinone oxidoreductase subunit S5
affects expression
EXP
Omeprazole affects the expression of NDUFS5 mRNA
CTD
PMID:19483382
NCBI chr 5:135,974,029...135,979,705
Ensembl chr 5:135,974,034...135,979,603 Ensembl chr14:135,974,034...135,979,603 Ensembl chr 2:135,974,034...135,979,603
G
Ndufv3
NADH:ubiquinone oxidoreductase subunit V3
affects expression
EXP
Omeprazole affects the expression of NDUFV3 mRNA
CTD
PMID:19483382
NCBI chr20:9,612,462...9,621,622
Ensembl chr20:9,612,431...9,623,074 Ensembl chr13:9,612,431...9,623,074
G
Neu2
neuraminidase 2
affects expression
EXP
Omeprazole affects the expression of NEU2 mRNA
CTD
PMID:19483382
NCBI chr 9:88,218,494...88,267,356
Ensembl chr 9:88,249,135...88,267,355
G
Nfe2l2
NFE2 like bZIP transcription factor 2
multiple interactions
ISO
NFE2L2 protein affects the reaction [Omeprazole results in increased expression of HMOX1 mRNA]; NFE2L2 protein affects the reaction [Omeprazole results in increased expression of HMOX1 protein]
CTD
PMID:27725188
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
G
Nfkbia
NFKB inhibitor alpha
multiple interactions
EXP
Omeprazole inhibits the reaction [Cisplatin results in decreased expression of NFKBIA protein]
CTD
PMID:32418911
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
G
Nfx1
nuclear transcription factor, X-box binding 1
affects expression
EXP
Omeprazole affects the expression of NFX1 mRNA
CTD
PMID:19483382
NCBI chr 5:56,104,945...56,162,912
Ensembl chr 5:56,105,234...56,162,912
G
Nipal2
NIPA-like domain containing 2
affects expression
EXP
Omeprazole affects the expression of NIPAL2 mRNA
CTD
PMID:19483382
NCBI chr 7:65,774,477...65,884,807
Ensembl chr 7:65,774,477...65,884,807
G
Nit1
nitrilase 1
affects expression
EXP
Omeprazole affects the expression of NIT1 mRNA
CTD
PMID:19483382
NCBI chr13:83,769,888...83,773,324
Ensembl chr13:83,765,941...83,773,332
G
Nlrp3
NLR family, pyrin domain containing 3
multiple interactions
EXP
Lipopolysaccharides inhibits the reaction [Omeprazole inhibits the reaction [Cisplatin results in increased expression of NLRP3 protein]]; Omeprazole inhibits the reaction [Cisplatin results in increased expression of NLRP3 protein]
CTD
PMID:32418911
NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
G
Nme2
NME/NM23 nucleoside diphosphate kinase 2
affects expression
EXP
Omeprazole affects the expression of NME2 mRNA
CTD
PMID:19483382
NCBI chr10:78,898,097...78,903,514
Ensembl chr10:78,897,770...78,903,538
G
Nqo1
NAD(P)H quinone dehydrogenase 1
increases expression multiple interactions
EXP ISO
Omeprazole results in increased expression of NQO1 mRNA Omeprazole inhibits the reaction [Oxygen results in increased expression of NQO1 mRNA]; Omeprazole inhibits the reaction [Oxygen results in increased expression of NQO1 protein] [Omeprazole co-treated with Diethylnitrosamine] results in increased expression of NQO1 mRNA
CTD
PMID:17202759 PMID:22687989 PMID:26272953
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
G
Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions increases activity
ISO EXP
[Omeprazole results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; NR1I2 protein affects the reaction [Omeprazole results in increased expression of CYP3A4 mRNA]
CTD
PMID:12695340 PMID:17041008 PMID:25680588 PMID:26187274 PMID:27732639
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
G
Nr1i3
nuclear receptor subfamily 1, group I, member 3
affects expression decreases metabolic processing increases expression
EXP ISO
Omeprazole affects the expression of NR1I3 mRNA NR1I3 gene mutant form results in decreased metabolism of Omeprazole Omeprazole results in increased expression of NR1I3 mRNA
CTD
PMID:19118567 PMID:19483382 PMID:27434302
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
G
Nr3c1
nuclear receptor subfamily 3, group C, member 1
affects expression
EXP
Omeprazole affects the expression of NR3C1 mRNA
CTD
PMID:19483382
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
G
Oaf
out at first homolog
affects expression
EXP
Omeprazole affects the expression of OAF mRNA
CTD
PMID:19483382
NCBI chr 8:43,594,362...43,612,334
Ensembl chr 8:43,594,363...43,612,334
G
Obp3
alpha-2u globulin PGCL4
affects expression
EXP
Omeprazole affects the expression of OBP3 mRNA
CTD
PMID:19483382
NCBI chr 5:74,842,316...74,845,858
Ensembl chr 5:74,842,316...74,845,757
G
Ogdh
oxoglutarate dehydrogenase
affects expression
EXP
Omeprazole affects the expression of OGDH mRNA
CTD
PMID:19483382
NCBI chr14:81,150,021...81,217,479
Ensembl chr14:81,150,091...81,217,479
G
Olr59
olfactory receptor 59
affects expression
EXP
Omeprazole affects the expression of OLR59 mRNA
CTD
PMID:19483382
NCBI chr 1:157,193,051...157,227,707
Ensembl chr 1:157,193,080...157,211,179
G
Ostc
oligosaccharyltransferase complex non-catalytic subunit
affects expression
EXP
Omeprazole affects the expression of OSTC mRNA
CTD
PMID:19483382
NCBI chr 2:219,250,549...219,266,076
Ensembl chr 2:219,236,952...219,266,107
G
Otc
ornithine transcarbamylase
affects expression
EXP
Omeprazole affects the expression of OTC mRNA
CTD
PMID:19483382
NCBI chr X:12,453,834...12,529,954
Ensembl chr X:12,453,834...12,566,918
G
Pabpc4
poly(A) binding protein, cytoplasmic 4
affects expression
EXP
Omeprazole affects the expression of PABPC4 mRNA
CTD
PMID:19483382
NCBI chr 5:135,563,142...135,578,985
Ensembl chr 5:135,563,562...135,578,979
G
Paics
phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
affects expression
EXP
Omeprazole affects the expression of PAICS mRNA
CTD
PMID:19483382
NCBI chr14:31,199,086...31,232,731
Ensembl chr14:31,173,541...31,232,635
G
Parp1
poly (ADP-ribose) polymerase 1
increases cleavage
ISO
Omeprazole results in increased cleavage of PARP1 protein
CTD
PMID:15461867
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
G
Pc
pyruvate carboxylase
affects expression
EXP
Omeprazole affects the expression of PCX mRNA
CTD
PMID:19483382
NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380
G
Pccb
propionyl-CoA carboxylase subunit beta
affects expression
EXP
Omeprazole affects the expression of PCCB mRNA
CTD
PMID:19483382
NCBI chr 8:101,591,218...101,641,213
Ensembl chr 8:101,590,737...101,641,234
G
Pcna
proliferating cell nuclear antigen
multiple interactions
EXP ISO
[Omeprazole co-treated with Indomethacin] promotes the reaction [Acetic Acid results in increased expression of PCNA protein]; Omeprazole promotes the reaction [Acetic Acid results in increased expression of PCNA protein] Omeprazole inhibits the reaction [Ethanol results in decreased expression of PCNA protein]
CTD
PMID:19251492 PMID:26970604
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
G
Pcsk6
proprotein convertase subtilisin/kexin type 6
affects expression
EXP
Omeprazole affects the expression of PCSK6 mRNA
CTD
PMID:19483382
NCBI chr 1:119,428,978...119,627,626
Ensembl chr 1:119,429,265...119,627,596
G
Pctp
phosphatidylcholine transfer protein
affects expression
EXP
Omeprazole affects the expression of PCTP mRNA
CTD
PMID:19483382
NCBI chr10:74,808,887...74,856,260
Ensembl chr10:74,808,887...74,849,867
G
Pdcl3
phosducin-like 3
affects expression
EXP
Omeprazole affects the expression of PDCL3 mRNA
CTD
PMID:19483382
NCBI chr 9:41,234,322...41,243,769
Ensembl chr 9:41,234,234...41,243,735
G
Pdia3
protein disulfide isomerase family A, member 3
affects expression
EXP
Omeprazole affects the expression of PDIA3 mRNA
CTD
PMID:19483382
NCBI chr 3:108,388,189...108,412,013
Ensembl chr 3:108,388,245...108,413,236
G
Pdia6
protein disulfide isomerase family A, member 6
affects expression
EXP
Omeprazole affects the expression of PDIA6 mRNA
CTD
PMID:19483382
NCBI chr 6:40,062,980...40,080,223
Ensembl chr 6:40,062,926...40,080,613
G
Pex19
peroxisomal biogenesis factor 19
affects expression
EXP
Omeprazole affects the expression of PEX19 mRNA
CTD
PMID:19483382
NCBI chr13:84,592,277...84,608,793
Ensembl chr13:84,592,312...84,608,608
G
Pgam1
phosphoglycerate mutase 1
affects expression
EXP
Omeprazole affects the expression of PGAM1 mRNA
CTD
PMID:19483382
NCBI chr 1:240,723,832...240,731,443
Ensembl chr 1:240,723,920...240,738,452
G
Pgrmc1
progesterone receptor membrane component 1
affects expression
EXP
Omeprazole affects the expression of PGRMC1 mRNA
CTD
PMID:19483382
NCBI chr X:115,832,865...115,841,060
Ensembl chr X:115,832,884...115,888,682
G
Phyh
phytanoyl-CoA 2-hydroxylase
affects expression
EXP
Omeprazole affects the expression of PHYH mRNA
CTD
PMID:19483382
NCBI chr17:73,329,461...73,346,359
Ensembl chr17:73,329,082...73,346,409
G
Pigp
phosphatidylinositol glycan anchor biosynthesis, class P
affects expression
EXP
Omeprazole affects the expression of PIGP mRNA
CTD
PMID:19483382
NCBI chr11:33,682,943...33,689,111
Ensembl chr11:33,682,948...33,689,321
G
Pklr
pyruvate kinase L/R
affects expression
EXP
Omeprazole affects the expression of PKLR mRNA
CTD
PMID:19483382
NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870
G
Pla2g4a
phospholipase A2 group IVA
increases phosphorylation multiple interactions
ISO
Omeprazole results in increased phosphorylation of PLA2G4A protein 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Omeprazole results in increased phosphorylation of PLA2G4A protein]
CTD
PMID:25797602
NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266
G
Plbd1
phospholipase B domain containing 1
affects expression
EXP
Omeprazole affects the expression of PLBD1 mRNA
CTD
PMID:19483382
NCBI chr 4:169,472,983...169,529,277
Ensembl chr 4:169,472,983...169,529,277
G
Plg
plasminogen
affects expression
EXP
Omeprazole affects the expression of PLG mRNA
CTD
PMID:19483382
NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786
G
Pls3
plastin 3
affects expression
EXP
Omeprazole affects the expression of PLS3 mRNA
CTD
PMID:19483382
NCBI chr X:111,589,193...111,683,908
Ensembl chr X:111,589,254...111,683,891
G
Pon2
paraoxonase 2
affects expression
EXP
Omeprazole affects the expression of PON2 mRNA
CTD
PMID:19483382
NCBI chr 4:33,389,702...33,425,186
Ensembl chr 4:33,389,714...33,425,248
G
Pou2f2
POU class 2 homeobox 2
multiple interactions
EXP ISO
Omeprazole inhibits the reaction [Cisplatin results in increased expression of POU2F2 protein]
CTD
PMID:30452898
NCBI chr 1:80,682,330...80,769,756
Ensembl chr 1:80,685,741...80,724,261
G
Ppdpf
pancreatic progenitor cell differentiation and proliferation factor
affects expression
EXP
Omeprazole affects the expression of PPDPF mRNA
CTD
PMID:19483382
NCBI chr 3:168,299,309...168,301,040
Ensembl chr 3:168,299,791...168,301,036
G
Prdx2
peroxiredoxin 2
affects expression
EXP
Omeprazole affects the expression of PRDX2 mRNA
CTD
PMID:19483382
NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194
G
Prdx6
peroxiredoxin 6
affects expression
EXP
Omeprazole affects the expression of PRDX6 mRNA
CTD
PMID:19483382
NCBI chr13:73,528,746...73,539,295
Ensembl chr13:73,528,210...73,539,355
G
Prl
prolactin
increases expression
ISO
Omeprazole results in increased expression of PRL protein
CTD
PMID:20726208
NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
G
Proc
protein C, inactivator of coagulation factors Va and VIIIa
affects expression
EXP
Omeprazole affects the expression of PROC mRNA
CTD
PMID:19483382
NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133
G
Prpsap1
phosphoribosyl pyrophosphate synthetase-associated protein 1
affects expression
EXP
Omeprazole affects the expression of PRPSAP1 mRNA
CTD
PMID:19483382
NCBI chr10:101,701,094...101,750,753
Ensembl chr10:101,701,096...101,750,751
G
Psma6
proteasome 20S subunit alpha 6
affects expression
EXP
Omeprazole affects the expression of PSMA6 mRNA
CTD
PMID:19483382
NCBI chr 6:72,765,534...72,796,554
Ensembl chr 6:72,765,473...72,796,554
G
Psmb1
proteasome 20S subunit beta 1
affects expression
EXP
Omeprazole affects the expression of PSMB1 mRNA
CTD
PMID:19483382
NCBI chr 1:56,442,432...56,463,544
Ensembl chr 1:56,420,618...56,463,560
G
Psmb3
proteasome 20S subunit beta 3
affects expression
EXP
Omeprazole affects the expression of PSMB3 mRNA
CTD
PMID:19483382
NCBI chr10:82,697,425...82,704,521
Ensembl chr10:82,697,425...82,704,521
G
Psmc1
proteasome 26S subunit, ATPase 1
affects expression
EXP
Omeprazole affects the expression of PSMC1 mRNA
CTD
PMID:19483382
NCBI chr 6:119,392,833...119,405,233
Ensembl chr 6:119,392,855...119,410,123
G
Psmc3
proteasome 26S subunit, ATPase 3
affects expression
EXP
Omeprazole affects the expression of PSMC3 mRNA
CTD
PMID:19483382
NCBI chr 3:77,031,825...77,037,207
Ensembl chr 3:77,031,825...77,043,358
G
Psmc5
proteasome 26S subunit, ATPase 5
affects expression
EXP
Omeprazole affects the expression of PSMC5 mRNA
CTD
PMID:19483382
NCBI chr10:91,187,763...91,193,697
Ensembl chr10:91,187,743...91,213,135
G
Psmd1
proteasome 26S subunit, non-ATPase 1
affects expression
EXP
Omeprazole affects the expression of PSMD1 mRNA
CTD
PMID:19483382
NCBI chr 9:86,709,714...86,785,213
Ensembl chr 9:86,709,947...86,785,211
G
Psmd4
proteasome 26S subunit ubiquitin receptor, non-ATPase 4
affects expression
EXP
Omeprazole affects the expression of PSMD4 mRNA
CTD
PMID:19483382
NCBI chr 2:182,598,934...182,608,250
Ensembl chr 2:182,598,934...182,608,194
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
EXP ISO
[Omeprazole co-treated with beta-Naphthoflavone] results in increased expression of PTGS2 mRNA; [Omeprazole co-treated with beta-Naphthoflavone] results in increased expression of PTGS2 protein Omeprazole inhibits the reaction [Ethanol results in increased expression of PTGS2 protein]
CTD
PMID:23038005 PMID:26970604
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
G
Ptms
parathymosin
affects expression
EXP
Omeprazole affects the expression of PTMS mRNA
CTD
PMID:19483382
NCBI chr 4:157,722,384...157,726,575
Ensembl chr 4:157,722,386...157,727,009
G
Ptprf
protein tyrosine phosphatase, receptor type, F
affects expression
EXP
Omeprazole affects the expression of PTPRF mRNA
CTD
PMID:19483382
NCBI chr 5:131,741,959...131,824,000
Ensembl chr 5:131,742,754...131,810,023
G
Pttg1ip
PTTG1 interacting protein
affects expression
EXP
Omeprazole affects the expression of PTTG1IP mRNA
CTD
PMID:19483382
NCBI chr20:11,030,013...11,047,742
Ensembl chr20:11,030,015...11,047,316
G
Pygl
glycogen phosphorylase L
affects expression
EXP
Omeprazole affects the expression of PYGL mRNA
CTD
PMID:19483382
NCBI chr 6:88,697,598...88,740,260
Ensembl chr 6:88,697,593...88,740,310
G
Rab5if
RAB5 interacting factor
affects expression
EXP
Omeprazole affects the expression of RAB5IF mRNA
CTD
PMID:19483382
NCBI chr 3:145,357,990...145,368,012
Ensembl chr 3:145,357,861...145,368,012
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
EXP ISO
[Omeprazole co-treated with Indomethacin] promotes the reaction [Acetic Acid results in increased expression of RELA protein]; Lipopolysaccharides inhibits the reaction [Omeprazole inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein]]; Omeprazole inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein] Omeprazole inhibits the reaction [Cisplatin affects the localization of RELA protein]
CTD
PMID:19251492 PMID:30452898 PMID:32418911
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
G
Retsat
retinol saturase
increases expression
EXP
Omeprazole results in increased expression of RETSAT mRNA
CTD
PMID:25626140
NCBI chr 4:104,653,306...104,662,069
Ensembl chr 4:104,653,155...104,668,310
G
Rida
reactive intermediate imine deaminase A homolog
affects expression
EXP
Omeprazole affects the expression of RIDA mRNA
CTD
PMID:19483382
NCBI chr 7:65,691,429...65,705,257
Ensembl chr 7:65,691,435...65,705,716
G
Rnase4
ribonuclease A family member 4
affects expression
EXP
Omeprazole affects the expression of RNASE4 mRNA
CTD
PMID:19483382
NCBI chr15:24,312,765...24,330,112
Ensembl chr15:24,312,464...24,330,117
G
Rnf103
ring finger protein 103
affects expression
EXP
Omeprazole affects the expression of RNF103 mRNA
CTD
PMID:19483382
NCBI chr 4:103,526,456...103,542,529
Ensembl chr 4:103,526,502...103,555,919
G
Rnps1
RNA binding protein with serine rich domain 1
affects expression
EXP
Omeprazole affects the expression of RNPS1 mRNA
CTD
PMID:19483382
NCBI chr10:13,445,516...13,455,858
Ensembl chr10:13,445,653...13,455,858
G
Rpl11
ribosomal protein L11
affects expression
EXP
Omeprazole affects the expression of RPL11 mRNA
CTD
PMID:19483382
NCBI chr 5:148,274,060...148,277,708
Ensembl chr 5:148,274,069...148,277,599
G
Rpl13
ribosomal protein L13
affects expression
EXP
Omeprazole affects the expression of RPL13 mRNA
CTD
PMID:19483382
NCBI chr19:51,153,990...51,156,541
Ensembl chr19:51,153,924...51,163,014
G
Rpl15
ribosomal protein L15
affects expression
EXP
Omeprazole affects the expression of RPL15 mRNA
CTD
PMID:19483382
NCBI chr15:7,503,883...7,507,166
Ensembl chr15:7,503,883...7,507,165
G
Rpl17
ribosomal protein L17
affects expression
EXP
Omeprazole affects the expression of RPL17 mRNA
CTD
PMID:19483382
NCBI chr18:68,581,141...68,584,253
Ensembl chr18:68,581,098...68,584,253
G
Rpl23
ribosomal protein L23
affects expression
EXP
Omeprazole affects the expression of RPL23 mRNA
CTD
PMID:19483382
NCBI chr10:82,771,878...82,775,840
Ensembl chr10:82,771,538...82,775,870
G
Rpl3
ribosomal protein L3
affects expression
EXP
Omeprazole affects the expression of RPL3 mRNA
CTD
PMID:19483382
NCBI chr 7:111,622,255...111,627,640
Ensembl chr 7:111,621,610...111,636,468
G
Rpl32
ribosomal protein L32
affects expression
EXP
Omeprazole affects the expression of RPL32 mRNA
CTD
PMID:19483382
NCBI chr 4:148,864,048...148,867,612
Ensembl chr 4:148,864,044...148,867,612
G
Rpl4
ribosomal protein L4
affects expression
EXP
Omeprazole affects the expression of RPL4 mRNA
CTD
PMID:19483382
NCBI chr 8:64,671,177...64,676,301
Ensembl chr 8:64,671,160...64,676,306
G
Rpn2
ribophorin II
affects expression
EXP
Omeprazole affects the expression of RPN2 mRNA
CTD
PMID:19483382
NCBI chr 3:145,941,787...145,989,271
Ensembl chr 3:145,941,839...145,989,543
G
Rps14
ribosomal protein S14
affects expression
EXP
Omeprazole affects the expression of RPS14 mRNA
CTD
PMID:19483382
NCBI chr18:54,227,854...54,232,638
Ensembl chr18:54,227,854...54,233,166
G
Rps18
ribosomal protein S18
affects expression
EXP
Omeprazole affects the expression of RPS18 mRNA
CTD
PMID:19483382
NCBI chr20:4,931,427...4,935,538
Ensembl chr10:101,204,500...101,205,146 Ensembl chr20:101,204,500...101,205,146
G
Rps19
ribosomal protein S19
affects expression
EXP
Omeprazole affects the expression of RPS19 mRNA
CTD
PMID:19483382
NCBI chr 1:80,480,718...80,486,511
Ensembl chr 1:80,480,951...80,486,508
G
Rps20
ribosomal protein S20
affects expression
EXP
Omeprazole affects the expression of RPS20 mRNA
CTD
PMID:19483382
NCBI chr 5:16,819,095...16,820,476
Ensembl chr 5:16,819,304...16,820,475 Ensembl chr 9:16,819,304...16,820,475 Ensembl chr 3:16,819,304...16,820,475
G
Rps3a
ribosomal protein S3a
affects expression
EXP
Omeprazole affects the expression of RPS3A mRNA
CTD
PMID:19483382
NCBI chr 2:171,524,685...171,529,054
Ensembl chr 2:171,524,500...171,529,055
G
Rps6
ribosomal protein S6
affects expression
EXP
Omeprazole affects the expression of RPS6 mRNA
CTD
PMID:19483382
NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602 Ensembl chr 5:101,371,136...101,374,602
G
Rps8
ribosomal protein S8
affects expression
EXP
Omeprazole affects the expression of RPS8 mRNA
CTD
PMID:19483382
NCBI chr 5:130,630,362...130,632,932
Ensembl chr 5:130,629,716...130,633,268
G
Rras2
RAS related 2
affects expression
EXP
Omeprazole affects the expression of RRAS2 mRNA
CTD
PMID:19483382
NCBI chr 1:168,233,693...168,303,111
Ensembl chr 1:168,233,693...168,303,111
G
RT1-DMa
RT1 class II, locus DMa
affects expression
ISO
Omeprazole affects the expression of HLA-DMA mRNA
CTD
PMID:25811541
NCBI chr20:4,707,028...4,710,432
Ensembl chr20:4,707,028...4,710,432
G
RT1-M3-1
RT1 class Ib, locus M3, gene 1
affects expression
ISO
Omeprazole affects the expression of HLA-G mRNA
CTD
PMID:25811541
NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117
G
RT1-S3
RT1 class Ib, locus S3
affects expression
EXP
Omeprazole affects the expression of RT1-S3 mRNA
CTD
PMID:19483382
NCBI chr20:2,670,654...2,675,411
Ensembl chr20:2,670,709...2,675,411
G
S1pr1
sphingosine-1-phosphate receptor 1
affects expression
EXP
Omeprazole affects the expression of S1PR1 mRNA
CTD
PMID:19483382
NCBI chr 2:203,624,752...203,629,110
Ensembl chr 2:203,621,587...203,629,681
G
Sbspon
somatomedin B and thrombospondin, type 1 domain containing
affects expression
EXP
Omeprazole affects the expression of SBSPON mRNA
CTD
PMID:19483382
NCBI chr 5:3,402,763...3,433,338
Ensembl chr 5:3,402,648...3,435,420
G
Sdc2
syndecan 2
affects expression
EXP
Omeprazole affects the expression of SDC2 mRNA
CTD
PMID:19483382
NCBI chr 7:64,127,185...64,239,885
Ensembl chr 7:64,127,110...64,241,081
G
Sdhc
succinate dehydrogenase complex subunit C
affects expression
EXP
Omeprazole affects the expression of SDHC mRNA
CTD
PMID:19483382
NCBI chr13:83,544,652...83,565,560
Ensembl chr13:83,544,652...83,566,253
G
Sdhd
succinate dehydrogenase complex subunit D
affects expression
EXP
Omeprazole affects the expression of SDHD mRNA
CTD
PMID:19483382
NCBI chr 8:50,944,702...50,954,298
Ensembl chr 8:50,944,704...50,954,238
G
Sell
selectin L
decreases expression
EXP
Omeprazole results in decreased expression of SELL protein
CTD
PMID:17652263
NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456
G
Serinc3
serine incorporator 3
affects expression
EXP
Omeprazole affects the expression of SERINC3 mRNA
CTD
PMID:19483382
NCBI chr 3:152,301,882...152,321,327
Ensembl chr 3:152,301,772...152,321,808
G
Serpina1
serpin family A member 1
affects expression
EXP
Omeprazole affects the expression of SERPINA1 mRNA
CTD
PMID:19483382
NCBI chr 6:122,866,314...122,888,339
Ensembl chr 6:122,866,312...122,888,339
G
Serpina10
serpin family A member 10
affects expression
EXP
Omeprazole affects the expression of SERPINA10 mRNA
CTD
PMID:19483382
NCBI chr 6:122,756,106...122,764,544
Ensembl chr 6:122,756,108...122,764,544
G
Serpina4
serpin family A member 4
affects expression
EXP
Omeprazole affects the expression of SERPINA4 mRNA
CTD
PMID:19483382
NCBI chr 6:122,999,970...123,009,083
Ensembl chr 6:122,999,900...123,009,082
G
Serpinf2
serpin family F member 2
affects expression
EXP
Omeprazole affects the expression of SERPINF2 mRNA
CTD
PMID:19483382
NCBI chr10:60,272,400...60,280,506
Ensembl chr10:60,272,400...60,281,243
G
Serping1
serpin family G member 1
decreases expression
EXP
Omeprazole results in decreased expression of SERPING1 mRNA
CTD
PMID:25626140
NCBI chr 3:69,842,726...69,852,583
Ensembl chr 3:69,842,739...69,852,034
G
Sfxn1
sideroflexin 1
affects expression
EXP
Omeprazole affects the expression of SFXN1 mRNA
CTD
PMID:19483382
NCBI chr17:10,486,250...10,522,640
Ensembl chr17:10,486,271...10,522,529
G
Shmt2
serine hydroxymethyltransferase 2
affects expression
EXP
Omeprazole affects the expression of SHMT2 mRNA
CTD
PMID:19483382
NCBI chr 7:63,358,961...63,364,293
Ensembl chr 7:63,358,961...63,364,236
G
Slc22a1
solute carrier family 22 member 1
affects expression
EXP
Omeprazole affects the expression of SLC22A1 mRNA
CTD
PMID:19483382
NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
G
Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Omeprazole inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
G
Slc22a5
solute carrier family 22 member 5
multiple interactions
EXP
Dithioerythritol inhibits the reaction [Omeprazole inhibits the reaction [SLC22A5 protein results in increased transport of Carnitine]]; Omeprazole inhibits the reaction [SLC22A5 protein results in increased transport of Carnitine]
CTD
PMID:19041296
NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309
G
Slc22a8
solute carrier family 22 member 8
multiple interactions
ISO
[Omeprazole results in decreased activity of SLC22A8 protein] which results in decreased uptake of Indican
CTD
PMID:36243147
NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
G
Slc23a1
solute carrier family 23 member 1
affects expression
EXP
Omeprazole affects the expression of SLC23A1 mRNA
CTD
PMID:19483382
NCBI chr18:27,214,940...27,230,564
Ensembl chr18:27,216,281...27,230,697
G
Slc25a13
solute carrier family 25 member 13
affects expression
EXP
Omeprazole affects the expression of SLC25A13 mRNA
CTD
PMID:19483382
NCBI chr 4:34,179,224...34,361,912
Ensembl chr 4:34,179,224...34,361,902
G
Slc25a3
solute carrier family 25 member 3
affects expression
EXP
Omeprazole affects the expression of SLC25A3 mRNA
CTD
PMID:19483382
NCBI chr 7:25,611,937...25,619,401
Ensembl chr 7:25,586,725...25,667,727
G
Slc27a2
solute carrier family 27 member 2
affects expression
EXP
Omeprazole affects the expression of SLC27A2 mRNA
CTD
PMID:19483382
NCBI chr 3:113,804,728...113,842,208
Ensembl chr 3:113,804,728...113,842,208
G
Slc39a8
solute carrier family 39 member 8
affects expression
EXP
Omeprazole affects the expression of SLC39A8 mRNA
CTD
PMID:19483382
NCBI chr 2:224,171,787...224,319,326
Ensembl chr 2:224,256,654...224,319,129
G
Slc40a1
solute carrier family 40 member 1
decreases expression
ISO
Omeprazole results in decreased expression of SLC40A1 protein
CTD
PMID:31669099
NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481
G
Slc46a1
solute carrier family 46 member 1
affects expression
EXP
Omeprazole affects the expression of SLC46A1 mRNA
CTD
PMID:19483382
NCBI chr10:63,361,504...63,367,940
Ensembl chr10:63,361,486...63,368,848
G
Slc66a2
solute carrier family 66 member 2
affects expression
EXP
Omeprazole affects the expression of SLC66A2 mRNA
CTD
PMID:19483382
NCBI chr18:73,702,472...73,739,678
Ensembl chr18:73,702,564...73,739,676
G
Slc6a6
solute carrier family 6 member 6
affects expression
EXP
Omeprazole affects the expression of SLC6A6 mRNA
CTD
PMID:19483382
NCBI chr 4:124,195,186...124,268,880
Ensembl chr 4:124,195,218...124,268,875
G
Slco1a4
solute carrier organic anion transporter family, member 1a4
increases expression
ISO
Omeprazole results in increased expression of SLCO1A2 mRNA
CTD
PMID:19118567
NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
G
Sod1
superoxide dismutase 1
multiple interactions
ISO
Omeprazole inhibits the reaction [Ethanol results in decreased activity of SOD1 protein]
CTD
PMID:28849987
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
G
Sppl2a
signal peptide peptidase-like 2A
affects expression
EXP
Omeprazole affects the expression of SPPL2A mRNA
CTD
PMID:19483382
NCBI chr 3:114,149,337...114,193,408
Ensembl chr 3:114,151,069...114,193,264
G
Srm
spermidine synthase
affects expression
EXP
Omeprazole affects the expression of SRM mRNA
CTD
PMID:19483382
NCBI chr 5:159,025,875...159,029,076
Ensembl chr 5:159,025,873...159,029,405
G
Srprb
SRP receptor subunit beta
affects expression
EXP
Omeprazole affects the expression of SRPRB mRNA
CTD
PMID:19483382
NCBI chr 8:103,768,685...103,782,632
G
Ssx2ip
SSX family member 2 interacting protein
affects expression
EXP
Omeprazole affects the expression of SSX2IP mRNA
CTD
PMID:19483382
NCBI chr 2:235,298,012...235,330,750
Ensembl chr 2:235,298,088...235,330,745
G
St3gal6
ST3 beta-galactoside alpha-2,3-sialyltransferase 6
affects expression
EXP
Omeprazole affects the expression of ST3GAL6 mRNA
CTD
PMID:19483382
NCBI chr11:42,061,282...42,121,801
Ensembl chr11:42,077,621...42,121,776
G
St6gal1
ST6 beta-galactoside alpha-2,6-sialyltransferase 1
affects expression
EXP
Omeprazole affects the expression of ST6GAL1 mRNA
CTD
PMID:19483382
NCBI chr11:77,526,837...77,653,474
Ensembl chr11:77,526,837...77,653,310
G
Suclg1
succinate-CoA ligase GDP/ADP-forming subunit alpha
affects expression
EXP
Omeprazole affects the expression of SUCLG1 mRNA
CTD
PMID:19483382
NCBI chr 4:105,308,236...105,337,595
Ensembl chr 4:105,308,039...105,337,600
G
Surf4
surfeit 4
affects expression
EXP
Omeprazole affects the expression of SURF4 mRNA
CTD
PMID:19483382
NCBI chr 3:10,248,360...10,261,537
Ensembl chr 3:10,241,837...10,263,315
G
Synj2bp
synaptojanin 2 binding protein
affects expression
EXP
Omeprazole affects the expression of SYNJ2BP mRNA
CTD
PMID:19483382
NCBI chr 6:101,189,714...101,227,400
Ensembl chr 6:101,189,714...101,227,406
G
Tacr1
tachykinin receptor 1
multiple interactions
ISO
Omeprazole inhibits the reaction [Acids affects the localization of TACR1 protein]
CTD
PMID:16091555
NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733
G
Tgfb1
transforming growth factor, beta 1
increases expression
ISO
Omeprazole results in increased expression of TGFB1 protein
CTD
PMID:36243147
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
G
Tgfbi
transforming growth factor, beta induced
affects expression
EXP
Omeprazole affects the expression of TGFBI mRNA
CTD
PMID:19483382
NCBI chr17:7,955,603...7,984,903
Ensembl chr17:7,955,603...7,985,240
G
Thnsl2
threonine synthase-like 2
affects expression
EXP
Omeprazole affects the expression of THNSL2 mRNA
CTD
PMID:19483382
NCBI chr 4:103,112,974...103,132,122
Ensembl chr 4:103,112,963...103,132,017
G
Timm21
translocase of inner mitochondrial membrane 21
affects expression
EXP
Omeprazole affects the expression of TIMM21 mRNA
CTD
PMID:19483382
NCBI chr18:78,314,900...78,319,362
Ensembl chr18:78,314,909...78,319,454
G
Timp2
TIMP metallopeptidase inhibitor 2
multiple interactions
EXP
Omeprazole inhibits the reaction [Indomethacin results in increased expression of TIMP2 protein]
CTD
PMID:16934674
NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611
G
Tkfc
triokinase and FMN cyclase
affects expression
EXP
Omeprazole affects the expression of TKFC mRNA
CTD
PMID:19483382
NCBI chr 1:207,238,230...207,253,035
Ensembl chr 1:207,236,557...207,252,737
G
Tlr4
toll-like receptor 4
multiple interactions
EXP
Lipopolysaccharides inhibits the reaction [Omeprazole inhibits the reaction [Cisplatin results in increased expression of TLR4 protein]]; Omeprazole inhibits the reaction [Cisplatin results in increased expression of TLR4 protein]
CTD
PMID:32418911
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
G
Tmbim1
transmembrane BAX inhibitor motif containing 1
affects expression
EXP
Omeprazole affects the expression of TMBIM1 mRNA
CTD
PMID:19483382
NCBI chr 9:75,871,835...75,889,366
Ensembl chr 9:75,871,835...75,889,069
G
Tmco1
transmembrane and coiled-coil domains 1
affects expression
EXP
Omeprazole affects the expression of TMCO1 mRNA
CTD
PMID:19483382
NCBI chr13:79,460,229...79,483,557
Ensembl chr13:79,460,135...79,483,555
G
Tmed2
transmembrane p24 trafficking protein 2
affects expression
EXP
Omeprazole affects the expression of TMED2 mRNA
CTD
PMID:19483382
NCBI chr12:32,052,542...32,061,628
Ensembl chr12:32,052,543...32,071,903
G
Tmed7
transmembrane p24 trafficking protein 7
affects expression
EXP
Omeprazole affects the expression of TMED7 mRNA
CTD
PMID:19483382
NCBI chr18:39,318,564...39,325,640
Ensembl chr18:39,297,351...39,325,640
G
Tmem123
transmembrane protein 123
affects expression
EXP
Omeprazole affects the expression of TMEM123 mRNA
CTD
PMID:19483382
NCBI chr 8:4,922,077...4,952,228
Ensembl chr 8:4,922,098...4,952,224
G
Tmem97
transmembrane protein 97
affects expression
EXP
Omeprazole affects the expression of TMEM97 mRNA
CTD
PMID:19483382
NCBI chr10:63,438,228...63,447,311
Ensembl chr10:63,438,222...63,589,730
G
Tnf
tumor necrosis factor
multiple interactions
ISO EXP
Omeprazole inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of TNF protein] Omeprazole inhibits the reaction [Ethanol results in increased expression of TNF protein] Omeprazole inhibits the reaction [Cisplatin results in increased expression of TNF protein]; Omeprazole inhibits the reaction [Ethanol results in decreased expression of TNF protein]
CTD
PMID:19232345 PMID:25637687 PMID:26970604 PMID:30452898 PMID:32418911
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
Txn1
thioredoxin 1
affects expression
EXP
Omeprazole affects the expression of TXN1 mRNA
CTD
PMID:19483382
NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
G
Txnl1
thioredoxin-like 1
affects expression
EXP
Omeprazole affects the expression of TXNL1 mRNA
CTD
PMID:19483382
NCBI chr18:57,125,362...57,155,167
Ensembl chr18:57,125,369...57,165,266
G
Tyr
tyrosinase
multiple interactions decreases expression
ISO
Omeprazole affects the N-linked glycosylation of and results in increased degradation of TYR protein; Omeprazole inhibits the reaction [ATP7A protein results in increased activity of TYR protein] Omeprazole results in decreased expression of TYR protein
CTD
PMID:25337692
NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207
G
Uba52
ubiquitin A-52 residue ribosomal protein fusion product 1
affects expression
EXP
Omeprazole affects the expression of UBA52 mRNA
CTD
PMID:19483382
NCBI chr16:18,918,614...18,920,807
Ensembl chr16:18,900,616...18,920,807
G
Ube2n
ubiquitin-conjugating enzyme E2N
affects expression
EXP
Omeprazole affects the expression of UBE2N mRNA
CTD
PMID:19483382
NCBI chr 7:30,154,330...30,184,373
Ensembl chr 7:30,154,616...30,184,355
G
Ufd1
ubiquitin recognition factor in ER associated degradation 1
affects expression
EXP
Omeprazole affects the expression of UFD1 mRNA
CTD
PMID:19483382
NCBI chr11:82,161,618...82,185,107
Ensembl chr11:82,161,619...82,185,087
G
Ugt1a1
UDP glucuronosyltransferase family 1 member A1
increases expression affects expression
ISO EXP
Omeprazole results in increased expression of UGT1A1 mRNA Omeprazole affects the expression of UGT1A1 mRNA
CTD
PMID:19118567 PMID:19483382 PMID:25626140
NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
G
Ugt1a2
UDP glucuronosyltransferase 1 family, polypeptide A2
increases expression
ISO
Omeprazole results in increased expression of UGT1A2 mRNA; Omeprazole results in increased expression of UGT1A3 mRNA
CTD
PMID:19118567
NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465
G
Ugt1a3
UDP glycosyltransferase 1 family, polypeptide A3
increases expression
ISO
Omeprazole results in increased expression of UGT1A5 mRNA
CTD
PMID:19118567
NCBI chr 9:88,780,328...88,808,465
Ensembl chr 9:88,713,184...88,808,465
G
Ugt1a5
UDP glucuronosyltransferase family 1 member A5
increases expression
ISO
Omeprazole results in increased expression of UGT1A4 mRNA
CTD
PMID:19118567
NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465
G
Ugt1a6
UDP glucuronosyltransferase family 1 member A6
increases expression multiple interactions
EXP ISO
Omeprazole results in increased expression of UGT1A6 mRNA [Omeprazole co-treated with Diethylnitrosamine] results in increased expression of UGT1A6 mRNA
CTD
PMID:19118567 PMID:22687989
NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465
G
Ugt1a9
UDP glucuronosyltransferase family 1 member A9
increases expression
ISO
Omeprazole results in increased expression of UGT1A9 mRNA
CTD
PMID:19118567
NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
G
Ugt2b1
UDP glucuronosyltransferase 2 family, polypeptide B1
increases expression
EXP
Omeprazole results in increased expression of UGT2B1 mRNA
CTD
PMID:25626140
NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
G
Uqcr11
ubiquinol-cytochrome c reductase, complex III subunit XI
affects expression
EXP
Omeprazole affects the expression of UQCR11 mRNA
CTD
PMID:19483382
NCBI chr 7:9,305,042...9,309,753
Ensembl chr 7:9,305,058...9,309,750
G
Vnn1
vanin 1
affects expression
EXP
Omeprazole affects the expression of VNN1 mRNA
CTD
PMID:19483382
NCBI chr 1:21,537,084...21,547,395
Ensembl chr 1:21,537,094...21,547,395
G
Wdr26
WD repeat domain 26
affects expression
EXP
Omeprazole affects the expression of WDR26 mRNA
CTD
PMID:19483382
NCBI chr13:92,930,282...92,972,061
Ensembl chr13:92,930,285...92,977,295
G
Ywhag
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
affects expression
EXP
Omeprazole affects the expression of YWHAG mRNA
CTD
PMID:19483382
NCBI chr12:20,744,500...20,772,828
Ensembl chr12:20,744,535...20,772,827
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Zdhhc23
zinc finger DHHC-type palmitoyltransferase 23
affects expression
EXP
Omeprazole affects the expression of ZDHHC23 mRNA
CTD
PMID:19483382
NCBI chr11:56,718,702...56,735,063
Ensembl chr11:56,718,826...56,734,194
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Zwint
ZW10 interacting kinetochore protein
affects expression
EXP
Omeprazole affects the expression of ZWINT mRNA
CTD
PMID:19483382
NCBI chr20:15,938,157...15,953,997
Ensembl chr20:15,938,157...15,953,957
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Got1
glutamic-oxaloacetic transaminase 1
increases expression
ISO
Oxaloacetic Acid results in increased expression of GOT1 mRNA
CTD
PMID:26811028
NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
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Mdh1
malate dehydrogenase 1
increases expression
ISO
Oxaloacetic Acid results in increased expression of MDH1 protein
CTD
PMID:26811028
NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925
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Mt-co2
mitochondrially encoded cytochrome c oxidase II
increases expression
ISO
Oxaloacetic Acid results in increased expression of COX2 mRNA; Oxaloacetic Acid results in increased expression of COX2 protein
CTD
PMID:26811028
NCBI chr MT:7,006...7,689 NCBI chr MT:7,006...7,689 NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689
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Ppargc1a
PPARG coactivator 1 alpha
increases expression
ISO
Oxaloacetic Acid results in increased expression of PPARGC1A mRNA; Oxaloacetic Acid results in increased expression of PPARGC1A protein
CTD
PMID:23056435 PMID:26811028
NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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Ppargc1b
PPARG coactivator 1 beta
increases expression
ISO
Oxaloacetic Acid results in increased expression of PPARGC1B protein
CTD
PMID:26811028
NCBI chr18:54,758,891...54,861,103
Ensembl chr18:54,758,902...54,861,194
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Pprc1
PPARG related coactivator 1
increases expression
ISO
Oxaloacetic Acid results in increased expression of PPRC1 mRNA; Oxaloacetic Acid results in increased expression of PPRC1 protein
CTD
PMID:26811028
NCBI chr 1:244,901,985...244,918,587
Ensembl chr 1:244,902,179...244,918,587
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Sirt1
sirtuin 1
multiple interactions
ISO
Oxaloacetic Acid results in increased expression of and results in increased phosphorylation of SIRT1 protein
CTD
PMID:26811028
NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
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Tfam
transcription factor A, mitochondrial
increases expression
ISO
Oxaloacetic Acid results in increased expression of TFAM mRNA
CTD
PMID:26811028
NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292
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Abca1
ATP binding cassette subfamily A member 1
increases expression
ISO
pantoprazole results in increased expression of ABCA1 mRNA
CTD
PMID:20060385
NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
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Abcc2
ATP binding cassette subfamily C member 2
multiple interactions
ISO
pantoprazole promotes the reaction [ABCC2 protein affects the transport of estradiol-17 beta-glucuronide]
CTD
PMID:12702717
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
G
Abcg2
ATP binding cassette subfamily G member 2
multiple interactions
ISO
pantoprazole inhibits the reaction [ABCG2 protein affects the transport of 7-hydroxymethotrexate]
CTD
PMID:17032904
NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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C1qa
complement C1q A chain
decreases expression
EXP
pantoprazole results in decreased expression of C1QA mRNA
CTD
PMID:25626140
NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534
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C1qc
complement C1q C chain
decreases expression
EXP
pantoprazole results in decreased expression of C1QC mRNA
CTD
PMID:25626140
NCBI chr 5:149,127,412...149,130,757
Ensembl chr 5:149,127,415...149,131,017
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C4bpa
complement component 4 binding protein, alpha
decreases expression
EXP
pantoprazole results in decreased expression of C4BPA mRNA
CTD
PMID:25626140
NCBI chr13:42,075,715...42,111,205
Ensembl chr13:42,075,717...42,111,205
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C4bpb
complement component 4 binding protein, beta
decreases expression
EXP
pantoprazole results in decreased expression of C4BPB mRNA
CTD
PMID:25626140
NCBI chr13:42,120,798...42,131,515
Ensembl chr13:42,120,798...42,131,817
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Casp3
caspase 3
multiple interactions
EXP
pantoprazole inhibits the reaction [Indomethacin results in increased activity of CASP3 protein]
CTD
PMID:18853145
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cfi
complement factor I
decreases expression
EXP
pantoprazole results in decreased expression of CFI mRNA
CTD
PMID:25626140
NCBI chr 2:218,389,079...218,430,565
Ensembl chr 2:218,387,990...218,430,561
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression decreases expression
EXP
pantoprazole results in increased expression of CYP1A1 protein pantoprazole results in decreased expression of CYP1A1 mRNA
CTD
PMID:9152597 PMID:25626140
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
increases expression
EXP
pantoprazole results in increased expression of CYP1A2 mRNA; pantoprazole results in increased expression of CYP1A2 protein
CTD
PMID:9152597 PMID:25626140
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp2b1
cytochrome P450, family 2, subfamily b, polypeptide 1
increases expression
EXP
pantoprazole results in increased expression of CYP2B1 protein
CTD
PMID:9152597
NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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Cyp2b2
cytochrome P450, family 2, subfamily b, polypeptide 2
increases expression
EXP
pantoprazole results in increased expression of CYP2B2 protein
CTD
PMID:9152597
NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
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Cyp2c11
cytochrome P450, subfamily 2, polypeptide 11
multiple interactions
ISO
Pantoprazole inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Diclofenac]
CTD
PMID:15258107
NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
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Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
affects response to substance multiple interactions decreases activity increases metabolic processing
ISO
CYP2C19 gene polymorphism affects the susceptibility to pantoprazole pantoprazole inhibits the reaction [CYP2C19 protein results in increased hydroxylation of Mephenytoin] pantoprazole results in decreased activity of CYP2C19 protein CYP2C19 protein results in increased metabolism of pantoprazole
CTD
PMID:8930576 PMID:15258107 PMID:20223877 PMID:21795468
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
multiple interactions
ISO
Pantoprazole results in increased expression of and results in increased activity of CYP2E1 protein
CTD
PMID:36243147
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases expression multiple interactions increases metabolic processing
ISO
Pantoprazole results in increased expression of CYP3A4 protein Pantoprazole inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam] CYP3A4 protein results in increased metabolism of Pantoprazole
CTD
PMID:8930576 PMID:9744552 PMID:15258107
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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Hamp
hepcidin antimicrobial peptide
increases expression
ISO
Pantoprazole results in increased expression of HAMP mRNA
CTD
PMID:31669099
NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
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Jak2
Janus kinase 2
multiple interactions
ISO
pantoprazole decreases expression of JAK2 mRNA and decreases phosphorylation of JAK2 protein in gastrocnemius
RGD
PMID:28489606
RGD:127285673
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
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Mpo
myeloperoxidase
multiple interactions
EXP
pantoprazole inhibits the reaction [Indomethacin results in increased expression of MPO protein]; pantoprazole inhibits the reaction [Ketoprofen results in increased expression of MPO protein]; pantoprazole inhibits the reaction [Piroxicam results in increased expression of MPO protein]
CTD
PMID:16080005
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Pcna
proliferating cell nuclear antigen
multiple interactions
EXP
[pantoprazole co-treated with Indomethacin] promotes the reaction [Acetic Acid results in increased expression of PCNA protein]; pantoprazole promotes the reaction [Acetic Acid results in increased expression of PCNA protein]
CTD
PMID:18853145
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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Retsat
retinol saturase
increases expression
EXP
pantoprazole results in increased expression of RETSAT mRNA
CTD
PMID:25626140
NCBI chr 4:104,653,306...104,662,069
Ensembl chr 4:104,653,155...104,668,310
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Serping1
serpin family G member 1
decreases expression
EXP
pantoprazole results in decreased expression of SERPING1 mRNA
CTD
PMID:25626140
NCBI chr 3:69,842,726...69,852,583
Ensembl chr 3:69,842,739...69,852,034
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Slc22a8
solute carrier family 22 member 8
multiple interactions
ISO
[Pantoprazole results in decreased activity of SLC22A8 protein] which results in decreased uptake of Indican
CTD
PMID:36243147
NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
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Tgfb1
transforming growth factor, beta 1
increases expression
ISO
Pantoprazole results in increased expression of TGFB1 protein
CTD
PMID:36243147
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
G
Ugt1a1
UDP glucuronosyltransferase family 1 member A1
increases expression
EXP
pantoprazole results in increased expression of UGT1A1 mRNA
CTD
PMID:25626140
NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
G
Ugt2b1
UDP glucuronosyltransferase 2 family, polypeptide B1
increases expression
EXP
pantoprazole results in increased expression of UGT2B1 mRNA
CTD
PMID:25626140
NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
G
Avpr1a
arginine vasopressin receptor 1A
multiple interactions
EXP
Pirenzepine binds to and results in decreased activity of AVPR1A protein
CTD
PMID:11553362
NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215
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Cd40
CD40 molecule
multiple interactions
ISO
Pirenzepine inhibits the reaction [Carbachol results in increased expression of CD40 protein]
CTD
PMID:16879495
NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
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Chrm1
cholinergic receptor, muscarinic 1
multiple interactions affects binding
ISO EXP
brucine affects the reaction [Pirenzepine analog binds to CHRM1 protein]; Pirenzepine inhibits the reaction [N-Methylscopolamine binds to CHRM1 protein]; Pirenzepine inhibits the reaction [Scopolamine Derivatives binds to CHRM1 protein] Pirenzepine binds to and results in decreased activity of CHRM1 protein; Pirenzepine inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]
CTD
PMID:8032910 PMID:9846649 PMID:11306684 PMID:12646291 PMID:15294002 PMID:18316702 More...
NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356
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Chrm5
cholinergic receptor, muscarinic 5
multiple interactions
ISO
Pirenzepine inhibits the reaction [N-Methylscopolamine binds to CHRM5 protein]
CTD
PMID:9846649
NCBI chr 3:99,284,846...99,337,252
Ensembl chr 3:99,284,846...99,337,252
G
Egr1
early growth response 1
multiple interactions
EXP
Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of EGR1 mRNA]
CTD
PMID:7968354
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
G
Egr2
early growth response 2
multiple interactions
EXP
Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of EGR2 mRNA]
CTD
PMID:7968354
NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions
EXP
Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of FOS mRNA]
CTD
PMID:7968354
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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Junb
JunB proto-oncogene, AP-1 transcription factor subunit
multiple interactions
EXP
Pirenzepine inhibits the reaction [Pilocarpine results in increased expression of JUNB mRNA]
CTD
PMID:7968354
NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
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Itgam
integrin subunit alpha M
multiple interactions
ISO
plaunotol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGAM protein]
CTD
PMID:10215738
NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503
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Itgb2
integrin subunit beta 2
multiple interactions
ISO
plaunotol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of ITGB2 protein]
CTD
PMID:10215738
NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600
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Tnf
tumor necrosis factor
decreases expression
ISO
plaunotol results in decreased expression of TNF protein
CTD
PMID:10215738
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
G
C1qa
complement C1q A chain
decreases expression
EXP
Rabeprazole results in decreased expression of C1QA mRNA
CTD
PMID:25626140
NCBI chr 5:149,133,635...149,136,482
Ensembl chr 5:149,133,636...149,136,534
G
C1qc
complement C1q C chain
decreases expression
EXP
Rabeprazole results in decreased expression of C1QC mRNA
CTD
PMID:25626140
NCBI chr 5:149,127,412...149,130,757
Ensembl chr 5:149,127,415...149,131,017
G
C4bpa
complement component 4 binding protein, alpha
decreases expression
EXP
Rabeprazole results in decreased expression of C4BPA mRNA
CTD
PMID:25626140
NCBI chr13:42,075,715...42,111,205
Ensembl chr13:42,075,717...42,111,205
G
C4bpb
complement component 4 binding protein, beta
decreases expression
EXP
Rabeprazole results in decreased expression of C4BPB mRNA
CTD
PMID:25626140
NCBI chr13:42,120,798...42,131,515
Ensembl chr13:42,120,798...42,131,817
G
Cfi
complement factor I
decreases expression
EXP
Rabeprazole results in decreased expression of CFI mRNA
CTD
PMID:25626140
NCBI chr 2:218,389,079...218,430,565
Ensembl chr 2:218,387,990...218,430,561
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression decreases activity
ISO EXP
Rabeprazole results in increased expression of CYP1A1 mRNA; Rabeprazole results in increased expression of CYP1A1 protein Rabeprazole results in decreased activity of CYP1A1 protein
CTD
PMID:9041675 PMID:12623754 PMID:25626140 PMID:33814510
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
increases expression
ISO EXP
Rabeprazole results in increased expression of CYP1A2 mRNA
CTD
PMID:12623754 PMID:25626140
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
G
Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
decreases activity
ISO
Rabeprazole results in decreased activity of CYP1B1 protein
CTD
PMID:33814510
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
G
Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
multiple interactions affects response to substance
ISO
CYP2C19 affects the susceptibility to [Tacrolimus co-treated with Rabeprazole] CYP2C19 gene affects the susceptibility to Rabeprazole
CTD
PMID:15903128 PMID:17377957
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
G
Cyp3a9
cytochrome P450, family 3, subfamily a, polypeptide 9
multiple interactions
ISO
CYP3A5 affects the susceptibility to [Tacrolimus co-treated with Rabeprazole]
CTD
PMID:17377957
NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
G
Hamp
hepcidin antimicrobial peptide
increases expression
ISO
Rabeprazole results in increased expression of HAMP mRNA
CTD
PMID:31669099
NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
G
Pomc
proopiomelanocortin
increases expression
ISO
Rabeprazole results in increased expression of POMC protein
CTD
PMID:16524691
NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
G
Retsat
retinol saturase
increases expression
EXP
Rabeprazole results in increased expression of RETSAT mRNA
CTD
PMID:25626140
NCBI chr 4:104,653,306...104,662,069
Ensembl chr 4:104,653,155...104,668,310
G
Serping1
serpin family G member 1
decreases expression
EXP
Rabeprazole results in decreased expression of SERPING1 mRNA
CTD
PMID:25626140
NCBI chr 3:69,842,726...69,852,583
Ensembl chr 3:69,842,739...69,852,034
G
Slc18a2
solute carrier family 18 member A2
multiple interactions
EXP
Rabeprazole promotes the reaction [SLC18A2 protein results in increased secretion of Histamine]
CTD
PMID:14642791
NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325
G
Slc22a2
solute carrier family 22 member 2
multiple interactions
ISO
Rabeprazole inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
CTD
PMID:21599003
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
G
Ugt1a1
UDP glucuronosyltransferase family 1 member A1
increases expression
EXP
Rabeprazole results in increased expression of UGT1A1 mRNA
CTD
PMID:25626140
NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
G
Ugt2b1
UDP glucuronosyltransferase 2 family, polypeptide B1
increases expression
EXP
Rabeprazole results in increased expression of UGT2B1 mRNA
CTD
PMID:25626140
NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
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Ache
acetylcholinesterase
multiple interactions
ISO EXP
Ranitidine binds to and results in decreased activity of ACHE protein; Ranitidine inhibits the reaction [Paraoxon results in decreased activity of ACHE protein] Ranitidine affects the reaction [Paraoxon results in decreased activity of ACHE protein]
CTD
PMID:15669026 PMID:15669039 PMID:16193528
NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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Ackr3
atypical chemokine receptor 3
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ACKR3 mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ACKR3 mRNA]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of ACKR3 mRNA]
CTD
PMID:16401727 PMID:16415329
NCBI chr 9:90,799,682...90,811,246
Ensembl chr 9:90,799,686...90,811,237
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Adamts1
ADAM metallopeptidase with thrombospondin type 1 motif, 1
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ADAMTS1 mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ADAMTS1 mRNA]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of ADAMTS1 mRNA]
CTD
PMID:16401727 PMID:16415329
NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103
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Alb
albumin
multiple interactions
EXP
[Ranitidine co-treated with Diclofenac] results in decreased expression of ALB protein; Quercetin inhibits the reaction [[Ranitidine co-treated with Diclofenac] results in decreased expression of ALB protein]
CTD
PMID:28400101
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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Aldoa
aldolase, fructose-bisphosphate A
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ALDOA mRNA
CTD
PMID:16415329
NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182
G
Amotl2
angiomotin like 2
multiple interactions
EXP
Ranitidine inhibits the reaction [Lipopolysaccharides results in increased expression of AMOTL2 mRNA]
CTD
PMID:16415329
NCBI chr 8:103,303,368...103,319,161
Ensembl chr 8:103,302,992...103,318,910
G
Arhgef11
Rho guanine nucleotide exchange factor 11
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ARHGEF11 mRNA
CTD
PMID:16415329
NCBI chr 2:173,074,383...173,195,962
Ensembl chr 2:173,074,368...173,196,010
G
Atf3
activating transcription factor 3
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ATF3 mRNA; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of ATF3 mRNA]
CTD
PMID:16401727 PMID:16415329
NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
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Atp1b1
ATPase Na+/K+ transporting subunit beta 1
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ATP1B1 mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ATP1B1 mRNA]; Ranitidine inhibits the reaction [Lipopolysaccharides results in decreased expression of ATP1B1 mRNA]
CTD
PMID:16401727 PMID:16415329
NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions
ISO EXP
Ranitidine inhibits the reaction [Rotenone results in increased expression of BAX protein] Ranitidine inhibits the reaction [Aspirin results in increased expression of BAX protein]
CTD
PMID:19723537 PMID:30885738
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bche
butyrylcholinesterase
multiple interactions
ISO
Ranitidine binds to and results in decreased activity of BCHE protein; Ranitidine inhibits the reaction [Paraoxon results in decreased activity of BCHE protein]
CTD
PMID:15669026 PMID:16193528
NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
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Bcl2
BCL2, apoptosis regulator
multiple interactions
ISO
Ranitidine inhibits the reaction [Rotenone results in decreased expression of BCL2 protein]
CTD
PMID:19723537
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bhlhe40
basic helix-loop-helix family, member e40
multiple interactions
EXP
Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of BHLHE40 mRNA]
CTD
PMID:16415329
NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774
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Bmp2
bone morphogenetic protein 2
multiple interactions
EXP
Ranitidine inhibits the reaction [Lipopolysaccharides results in decreased expression of BMP2 mRNA]
CTD
PMID:16415329
NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
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Bnip3
BCL2 interacting protein 3
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of BNIP3 mRNA
CTD
PMID:16401727 PMID:16415329
NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
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Btg2
BTG anti-proliferation factor 2
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of BTG2 mRNA; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of BTG2 mRNA]
CTD
PMID:16401727 PMID:16415329
NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
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Calca
calcitonin-related polypeptide alpha
increases expression
ISO
Ranitidine results in increased expression of CALCA protein
CTD
PMID:12495560
NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
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Casp3
caspase 3
multiple interactions
ISO EXP
Ranitidine inhibits the reaction [Rotenone results in increased cleavage of and results in increased activity of CASP3 protein] Ranitidine inhibits the reaction [Aspirin results in increased expression of CASP3 mRNA]; Ranitidine inhibits the reaction [Aspirin results in increased expression of CASP3 protein]; Ranitidine inhibits the reaction [Indomethacin results in increased expression of CASP3 mRNA]; Ranitidine inhibits the reaction [Indomethacin results in increased expression of CASP3 protein]
CTD
PMID:19723537 PMID:28648817 PMID:29523851 PMID:30580614 PMID:30885738
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp9
caspase 9
multiple interactions
ISO
Ranitidine inhibits the reaction [Rotenone results in increased cleavage of CASP9 protein]
CTD
PMID:19723537
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cat
catalase
multiple interactions
EXP
Ranitidine inhibits the reaction [Indomethacin results in decreased activity of CAT protein]; Ranitidine inhibits the reaction [Indomethacin results in increased activity of CAT protein]
CTD
PMID:16169175 PMID:16397915 PMID:17895592 PMID:18087811 PMID:18726076
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Ccnl1
cyclin L1
multiple interactions
EXP
Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of CCNL1 mRNA]
CTD
PMID:16415329
NCBI chr 2:150,184,865...150,199,524
Ensembl chr 2:150,184,798...150,197,368
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Cd80
Cd80 molecule
multiple interactions
ISO
Ranitidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of CD80 protein]]
CTD
PMID:12538815
NCBI chr11:62,254,543...62,293,414
Ensembl chr11:62,254,624...62,292,030
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Cdk6
cyclin-dependent kinase 6
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in decreased expression of CDK6 mRNA
CTD
PMID:16415329
NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
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Crem
cAMP responsive element modulator
multiple interactions
EXP
Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of CREM mRNA]
CTD
PMID:16415329
NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989
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Csf3
colony stimulating factor 3
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of CSF3 mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of CSF3 mRNA]
CTD
PMID:16401727
NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603
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Ctsl
cathepsin L
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of CTSL mRNA
CTD
PMID:16415329
NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
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Cxcl1
C-X-C motif chemokine ligand 1
decreases expression
EXP
Ranitidine results in decreased expression of CXCL1 protein
CTD
PMID:12023551
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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Cxcl2
C-X-C motif chemokine ligand 2
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of CXCL2 mRNA; [Ranitidine co-treated with Lipopolysaccharides] results in increased expression of CXCL2 protein; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of CXCL2 mRNA]; Heparin inhibits the reaction [Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of CXCL2 protein]]; Pentoxifylline inhibits the reaction [[Ranitidine co-treated with Lipopolysaccharides] results in increased expression of CXCL2 protein]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of CXCL2 mRNA]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of CXCL2 protein]
CTD
PMID:16401727 PMID:16415329 PMID:17698507
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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Ddah1
dimethylarginine dimethylaminohydrolase 1
multiple interactions
EXP
Ranitidine inhibits the reaction [Indomethacin results in decreased expression of DDAH1 mRNA]
CTD
PMID:29523851
NCBI chr 2:234,667,499...234,800,322
Ensembl chr 2:234,667,491...234,799,339
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Ddit4
DNA-damage-inducible transcript 4
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of DDIT4 mRNA
CTD
PMID:16415329
NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
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Dio3
iodothyronine deiodinase 3
multiple interactions
EXP
Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of DIO3 mRNA]
CTD
PMID:16415329
NCBI chr 6:129,285,747...129,287,608
Ensembl chr 6:129,285,749...129,286,660
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Dusp1
dual specificity phosphatase 1
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of DUSP1 mRNA
CTD
PMID:16415329
NCBI chr10:16,680,478...16,683,275
G
Efna1
ephrin A1
multiple interactions
EXP
Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of EFNA1 mRNA]
CTD
PMID:16415329
NCBI chr 2:174,681,676...174,689,061
Ensembl chr 2:174,681,682...174,690,866
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Egfl7
EGF-like-domain, multiple 7
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in decreased expression of EGFL7 mRNA
CTD
PMID:16415329
NCBI chr 3:9,404,622...9,416,879
Ensembl chr 3:9,407,520...9,416,879
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Egfr
epidermal growth factor receptor
multiple interactions
EXP
Ranitidine inhibits the reaction [Indomethacin results in increased expression of EGFR mRNA]
CTD
PMID:29523851
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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Egln3
egl-9 family hypoxia-inducible factor 3
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of EGLN3 mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of EGLN3 mRNA]
CTD
PMID:16401727 PMID:16415329
NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766
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Egr1
early growth response 1
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of EGR1 mRNA; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of EGR1 mRNA]
CTD
PMID:16401727 PMID:16415329
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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F3
coagulation factor III, tissue factor
multiple interactions
EXP
Ranitidine inhibits the reaction [Lipopolysaccharides results in decreased expression of F3 mRNA]
CTD
PMID:16415329
NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668
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Fgf23
fibroblast growth factor 23
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of FGF23 mRNA
CTD
PMID:16415329
NCBI chr 4:159,914,267...159,923,821
Ensembl chr 4:159,914,272...159,923,821
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Fmo3
flavin containing dimethylaniline monoxygenase 3
affects metabolic processing
ISO
FMO3 protein affects the metabolism of Ranitidine
CTD
PMID:15286053
NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of FOS mRNA
CTD
PMID:16415329
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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Fosl2
FOS like 2, AP-1 transcription factor subunit
multiple interactions
EXP
Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of FOSL2 mRNA]
CTD
PMID:16415329
NCBI chr 6:24,297,898...24,319,219
Ensembl chr 6:24,300,956...24,320,034
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Foxq1
forkhead box Q1
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of FOXQ1 mRNA
CTD
PMID:16415329
NCBI chr17:32,912,744...32,915,377
Ensembl chr17:32,912,744...32,915,377 Ensembl chr17:32,912,744...32,915,377
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Fst
follistatin
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of FST mRNA; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of FST mRNA]
CTD
PMID:16415329
NCBI chr 2:46,123,260...46,130,584
Ensembl chr 2:46,123,439...46,130,571
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Gadd45a
growth arrest and DNA-damage-inducible, alpha
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of GADD45A mRNA
CTD
PMID:16415329
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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Gast
gastrin
affects expression multiple interactions
ISO EXP
Ranitidine affects the expression of GAST protein Ranitidine inhibits the reaction [GAST protein modified form results in increased secretion of Acids]
CTD
PMID:2470453 PMID:12503773
NCBI chr10:85,264,832...85,269,393
Ensembl chr10:85,264,832...85,267,496
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Got1
glutamic-oxaloacetic transaminase 1
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of GOT1 mRNA
CTD
PMID:16415329
NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
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Gzmb
granzyme B
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of GZMB mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of GZMB mRNA]
CTD
PMID:16401727
NCBI chr15:30,343,352...30,346,814
Ensembl chr15:30,173,603...30,346,814
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H2ac25
H2A clustered histone 25
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of H2A mRNA
CTD
PMID:16415329
NCBI chr10:43,733,702...43,735,254
Ensembl chr10:43,733,668...43,744,874
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Hmox1
heme oxygenase 1
multiple interactions
EXP
Ranitidine inhibits the reaction [Indomethacin results in decreased expression of HMOX1 mRNA]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of HMOX1 mRNA]
CTD
PMID:16415329 PMID:30580614
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Hnf4a
hepatocyte nuclear factor 4, alpha
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in decreased expression of HNF4A mRNA
CTD
PMID:16415329
NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320
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Homer1
homer scaffold protein 1
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of HOMER1 mRNA
CTD
PMID:16415329
NCBI chr 2:24,542,777...24,645,715
Ensembl chr 2:24,543,093...24,644,785
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Hoxa5
homeo box A5
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of HOXA5 mRNA
CTD
PMID:16415329
NCBI chr 4:81,302,341...81,306,234
Ensembl chr 4:81,302,353...81,306,234
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Hrh2
histamine receptor H 2
multiple interactions decreases activity
ISO EXP
[Ranitidine binds to and results in decreased activity of HRH2 protein] which affects the susceptibility to Metformin; Ranitidine binds to and results in decreased activity of HRH2 protein; Ranitidine inhibits the reaction [tiotidine binds to HRH2 protein] Ranitidine binds to and results in decreased activity of HRH2 protein; Ranitidine inhibits the reaction [Dimaprit binds to and results in increased activity of HRH2 protein]; Ranitidine inhibits the reaction [Melitten results in increased activity of HRH2 protein] Ranitidine results in decreased activity of HRH2 protein
CTD
PMID:6106871 PMID:6835285 PMID:7512805 PMID:9681472 PMID:9819373 PMID:11527950 PMID:12100006 PMID:14671421 PMID:16143415 PMID:16632449 PMID:22995146 More...
NCBI chr17:10,366,004...10,407,791
Ensembl chr17:10,368,298...10,407,631
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Hspa1a
heat shock protein family A (Hsp70) member 1A
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of HSPA1A mRNA
CTD
PMID:16415329
NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
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Hspb8
heat shock protein family B (small) member 8
multiple interactions
EXP
Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of HSPB8 mRNA]
CTD
PMID:16415329
NCBI chr12:40,176,405...40,205,002
Ensembl chr12:40,176,532...40,191,185
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Icam1
intercellular adhesion molecule 1
multiple interactions
ISO
Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 protein]]
CTD
PMID:11752121 PMID:12538815
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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Id2
inhibitor of DNA binding 2
multiple interactions
EXP
Ranitidine inhibits the reaction [Lipopolysaccharides results in decreased expression of ID2 mRNA]
CTD
PMID:16415329
NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400
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Id4
inhibitor of DNA binding 4
multiple interactions
EXP
Ranitidine inhibits the reaction [Lipopolysaccharides results in decreased expression of ID4 mRNA]
CTD
PMID:16415329
NCBI chr17:16,389,387...16,391,956
Ensembl chr17:16,389,387...16,392,470
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Ifng
interferon gamma
multiple interactions
ISO EXP
Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]] [IFNG protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Ranitidine; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of IFNG mRNA]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of IFNG protein]
CTD
PMID:10569698 PMID:11752121 PMID:16415329 PMID:17698507 PMID:19362101
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Ifrd1
interferon-related developmental regulator 1
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of IFRD1 mRNA
CTD
PMID:16415329
NCBI chr 6:57,269,395...57,317,833
Ensembl chr 6:57,269,384...57,288,990
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Igsf10
immunoglobulin superfamily, member 10
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of IGSF10 mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of IGSF10 mRNA]
CTD
PMID:16401727
NCBI chr 2:143,575,710...143,605,044
Ensembl chr 2:143,576,070...143,604,773
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Il10
interleukin 10
multiple interactions
EXP ISO
Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of IL10 protein] Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]
CTD
PMID:11752121 PMID:17698507
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il12a
interleukin 12A
multiple interactions
ISO
Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]; Ranitidine inhibits the reaction [Histamine results in decreased expression of IL12A protein]
CTD
PMID:9819373 PMID:11752121
NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734
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Il12b
interleukin 12B
multiple interactions
ISO
Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]; Ranitidine inhibits the reaction [Histamine results in decreased expression of IL12B protein]
CTD
PMID:9819373 PMID:11752121
NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
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Il18
interleukin 18
multiple interactions
ISO
Ranitidine inhibits the reaction [Cimetidine results in increased expression of IL18 protein]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in decreased expression of IL10 protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of [IL12A protein binds to IL12B protein]]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of ICAM1 protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of IFNG protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]]
CTD
PMID:11752121 PMID:16723495
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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Il1a
interleukin 1 alpha
multiple interactions
EXP
[IFNG protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Ranitidine
CTD
PMID:19362101
NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
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Il1b
interleukin 1 beta
multiple interactions increases expression
EXP
Pentoxifylline inhibits the reaction [Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; Ranitidine inhibits the reaction [Capsaicin results in increased expression of IL1B protein]; Ranitidine inhibits the reaction [Indomethacin results in increased expression of IL1B mRNA]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of IL1B protein] Ranitidine results in increased expression of IL1B protein
CTD
PMID:15265675 PMID:17698507 PMID:30580614
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il4
interleukin 4
multiple interactions
EXP
Ranitidine inhibits the reaction [Indomethacin results in increased expression of IL4 protein]
CTD
PMID:29523851
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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Il6
interleukin 6
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of IL6 mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of IL6 mRNA]; Pentoxifylline inhibits the reaction [Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; Ranitidine inhibits the reaction [Capsaicin results in increased expression of IL6 protein]; Ranitidine inhibits the reaction [Indomethacin results in increased expression of IL6 protein]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
CTD
PMID:15265675 PMID:16401727 PMID:16415329 PMID:17698507 PMID:28648817
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Inhbe
inhibin subunit beta E
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in decreased expression of INHBE mRNA
CTD
PMID:16415329
NCBI chr 7:63,176,221...63,179,209
Ensembl chr 7:63,176,219...63,179,172
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Insig1
insulin induced gene 1
multiple interactions
EXP
Ranitidine inhibits the reaction [Lipopolysaccharides results in decreased expression of INSIG1 mRNA]
CTD
PMID:16415329
NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952
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Insig2
insulin induced gene 2
multiple interactions
EXP
Ranitidine inhibits the reaction [Lipopolysaccharides results in decreased expression of INSIG2 mRNA]
CTD
PMID:16415329
NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923
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Irs2
insulin receptor substrate 2
multiple interactions
EXP
Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of IRS2 mRNA]
CTD
PMID:16415329
NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482
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Itpkc
inositol-trisphosphate 3-kinase C
multiple interactions
EXP
Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of ITPKC mRNA]
CTD
PMID:16415329
NCBI chr 1:82,500,957...82,522,533
Ensembl chr 1:82,500,957...82,522,779
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
multiple interactions
EXP
Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of JUN mRNA]
CTD
PMID:16415329
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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Klf4
KLF transcription factor 4
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of KLF4 mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of KLF4 mRNA]
CTD
PMID:16401727 PMID:16415329
NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602
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Klf6
KLF transcription factor 6
multiple interactions
EXP
Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of KLF6 mRNA]
CTD
PMID:16415329
NCBI chr17:64,539,456...64,548,451
Ensembl chr17:64,531,463...64,588,570
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Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO
Ranitidine inhibits the reaction [Rotenone results in increased phosphorylation of MAPK1 protein]
CTD
PMID:19723537
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
Ranitidine inhibits the reaction [Rotenone results in increased phosphorylation of MAPK3 protein]
CTD
PMID:19723537
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Mapkapk2
MAPK activated protein kinase 2
increases expression multiple interactions
EXP
Ranitidine results in increased expression of MAPKAPK2 mRNA [Lipopolysaccharides co-treated with Ranitidine] results in increased expression of MAPKAPK2 mRNA
CTD
PMID:16401727 PMID:16415329
NCBI chr13:42,513,762...42,560,061
Ensembl chr13:42,513,762...42,560,457
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Mmp9
matrix metallopeptidase 9
multiple interactions
EXP
Ranitidine inhibits the reaction [Ethanol results in increased secretion of and results in increased activity of MMP9 protein]; Ranitidine inhibits the reaction [Indomethacin results in increased expression of MMP9 protein]
CTD
PMID:17603938 PMID:29523851
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Mpo
myeloperoxidase
decreases expression multiple interactions
EXP
Ranitidine results in decreased expression of MPO protein Ranitidine inhibits the reaction [Aspirin results in increased expression of MPO protein]; Ranitidine inhibits the reaction [Indomethacin results in increased activity of MPO protein]
CTD
PMID:12023551 PMID:16169175 PMID:17895592 PMID:18726076 PMID:28648817 PMID:30885738 More...
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Myc
MYC proto-oncogene, bHLH transcription factor
multiple interactions
EXP
Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of MYC mRNA]
CTD
PMID:16415329
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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Nedd4l
NEDD4 like E3 ubiquitin protein ligase
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of NEDD4L mRNA
CTD
PMID:16415329
NCBI chr18:58,393,759...58,726,709
Ensembl chr18:58,393,509...58,723,137
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Nfe2l2
NFE2 like bZIP transcription factor 2
multiple interactions
EXP
Ranitidine inhibits the reaction [Indomethacin results in decreased expression of NFE2L2 mRNA]
CTD
PMID:28648817
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Ngf
nerve growth factor
multiple interactions
EXP
Ranitidine inhibits the reaction [Capsaicin results in increased expression of NGF protein]
CTD
PMID:15265675
NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
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Noct
nocturnin
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of NOCT mRNA
CTD
PMID:16415329
NCBI chr 2:135,271,189...135,291,407
Ensembl chr 2:135,271,189...135,291,400
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Nos2
nitric oxide synthase 2
multiple interactions
EXP
Ranitidine inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]
CTD
PMID:16169175
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Nqo1
NAD(P)H quinone dehydrogenase 1
multiple interactions
EXP
Ranitidine inhibits the reaction [Indomethacin results in decreased expression of NQO1 protein]
CTD
PMID:30580614
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Nr4a1
nuclear receptor subfamily 4, group A, member 1
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of NR4A1 mRNA
CTD
PMID:16415329
NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
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Nupr1
nuclear protein 1, transcriptional regulator
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of NUPR1 mRNA
CTD
PMID:16415329
NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281
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P4ha1
prolyl 4-hydroxylase subunit alpha 1
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of P4HA1 mRNA
CTD
PMID:16415329
NCBI chr20:27,302,046...27,352,098
Ensembl chr20:27,302,141...27,352,786
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Parp1
poly (ADP-ribose) polymerase 1
multiple interactions
ISO
Ranitidine inhibits the reaction [Rotenone results in increased cleavage of PARP1 protein]
CTD
PMID:19723537
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Pfkl
phosphofructokinase, liver type
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of PFKL mRNA
CTD
PMID:16415329
NCBI chr20:10,664,285...10,686,324
Ensembl chr20:10,664,272...10,686,315
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Ppp1r15a
protein phosphatase 1, regulatory subunit 15A
multiple interactions
EXP
Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of PPP1R15A mRNA]
CTD
PMID:16415329
NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
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Preb
prolactin regulatory element binding
multiple interactions
EXP
Ranitidine inhibits the reaction [Lipopolysaccharides results in increased expression of PREB mRNA]
CTD
PMID:16415329
NCBI chr 6:25,418,805...25,422,594
Ensembl chr 6:25,418,776...25,422,590
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Prl
prolactin
affects expression increases secretion
ISO
Ranitidine affects the expression of PRL protein Ranitidine results in increased secretion of PRL protein
CTD
PMID:7878608 PMID:9037573
NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of PTGS2 mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of PTGS2 mRNA]; Ranitidine inhibits the reaction [Indomethacin results in increased expression of PTGS2 mRNA]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]
CTD
PMID:16401727 PMID:16415329 PMID:29523851
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Pvr
PVR cell adhesion molecule
multiple interactions
EXP
Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of PVR mRNA]
CTD
PMID:16415329
NCBI chr 1:79,561,294...79,576,700
Ensembl chr 1:79,546,879...79,576,715
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Rac1
Rac family small GTPase 1
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of RAC1 mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of RAC1 mRNA]
CTD
PMID:16401727
NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
EXP
Ranitidine inhibits the reaction [Indomethacin results in increased expression of RELA mRNA]; Ranitidine inhibits the reaction [Indomethacin results in increased expression of RELA protein]
CTD
PMID:28648817 PMID:30580614
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Ren
renin
affects activity
ISO
Ranitidine affects the activity of REN protein
CTD
PMID:1972605
NCBI chr13:44,796,260...44,807,491
Ensembl chr13:44,796,091...44,807,489
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Rgs2
regulator of G-protein signaling 2
multiple interactions
EXP
Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of RGS2 mRNA]
CTD
PMID:16415329
NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385
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Rgs4
regulator of G-protein signaling 4
multiple interactions
EXP
Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of RGS4 mRNA]
CTD
PMID:16415329
NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068
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Rhob
ras homolog family member B
multiple interactions
EXP
Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of ARHB mRNA]
CTD
PMID:16415329
NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108
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Serpine1
serpin family E member 1
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of SERPINE1 mRNA; Heparin inhibits the reaction [Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 protein]]; Pentoxifylline inhibits the reaction [Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 protein]]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 mRNA]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SERPINE1 protein]
CTD
PMID:16401727 PMID:16415329 PMID:17698507
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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Sh2b2
SH2B adaptor protein 2
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of APS mRNA
CTD
PMID:16415329
NCBI chr12:20,427,057...20,456,845
Ensembl chr12:20,429,043...20,456,844
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Shank3
SH3 and multiple ankyrin repeat domains 3
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in decreased expression of SHANK3 mRNA
CTD
PMID:16415329
NCBI chr 7:120,568,707...120,630,796
Ensembl chr 7:120,570,402...120,630,374
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Sik1
salt-inducible kinase 1
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of SIK1 mRNA; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SIK1 mRNA]
CTD
PMID:16415329
NCBI chr20:9,949,407...9,959,036
Ensembl chr20:9,947,396...9,958,991
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Slc16a6
solute carrier family 16, member 6
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of SLC16A6 mRNA
CTD
PMID:16415329
NCBI chr10:94,424,377...94,447,482
Ensembl chr10:94,426,244...94,448,779
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Slc20a1
solute carrier family 20 member 1
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of SLC20A1 mRNA
CTD
PMID:16415329
NCBI chr 3:116,427,095...116,441,049
Ensembl chr 3:116,427,098...116,441,051
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Slc22a1
solute carrier family 22 member 1
multiple interactions increases uptake affects transport
ISO EXP
Ranitidine inhibits the reaction [SLC22A1 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Ranitidine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] SLC22A1 protein results in increased uptake of Ranitidine SLC22A1 protein affects the transport of Ranitidine
CTD
PMID:16006492 PMID:16141367 PMID:16263091
NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
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Slc22a2
solute carrier family 22 member 2
increases uptake multiple interactions
ISO EXP
SLC22A2 protein results in increased uptake of Ranitidine Ranitidine inhibits the reaction [SLC22A2 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Ranitidine inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
CTD
PMID:16006492 PMID:16141367 PMID:16263091
NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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Slc22a3
solute carrier family 22 member 3
multiple interactions
ISO
Ranitidine inhibits the reaction [SLC22A3 protein affects the transport of 1-Methyl-4-phenylpyridinium]; Ranitidine inhibits the reaction [SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium]; Ranitidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
CTD
PMID:16141367 PMID:16263091
NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
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Slc22a6
solute carrier family 22 member 6
increases uptake
ISO
SLC22A6 protein results in increased uptake of Ranitidine
CTD
PMID:16006492
NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
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Slc22a7
solute carrier family 22 member 7
increases uptake
ISO
SLC22A7 protein results in increased uptake of Ranitidine
CTD
PMID:16006492
NCBI chr 9:14,547,073...14,554,354
Ensembl chr 9:14,547,849...14,553,921
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Slc22a8
solute carrier family 22 member 8
increases uptake multiple interactions
ISO EXP
SLC22A8 protein results in increased uptake of Ranitidine Penicillin G inhibits the reaction [SLC22A8 protein results in increased uptake of Ranitidine]; Probenecid promotes the reaction [SLC22A8 protein results in increased uptake of Ranitidine]; Ranitidine inhibits the reaction [SLC22A8 protein results in increased uptake of Cimetidine]
CTD
PMID:15319347 PMID:16006492
NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
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Slc2a1
solute carrier family 2 member 1
multiple interactions
EXP
Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SLC2A1 mRNA]
CTD
PMID:16415329
NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
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Slc38a2
solute carrier family 38, member 2
multiple interactions
EXP
Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SLC38A2 mRNA]
CTD
PMID:16415329
NCBI chr 7:127,851,267...127,863,482
Ensembl chr 7:127,851,267...127,863,436
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Slc47a1
solute carrier family 47 member 1
multiple interactions
ISO
Ranitidine inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
CTD
PMID:22419765
NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
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Slc47a2
solute carrier family 47 member 2
multiple interactions
ISO
Ranitidine inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
CTD
PMID:22419765
NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904
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Slc5a3
solute carrier family 5 member 3
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of SLC5A3 mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of SLC5A3 mRNA]
CTD
PMID:16401727
NCBI chr11:31,313,847...31,316,293
Ensembl chr11:31,295,476...31,318,883
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Slk
STE20-like kinase
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of SLK mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of SLK mRNA]
CTD
PMID:16401727
NCBI chr 1:246,473,712...246,529,643
Ensembl chr 1:246,473,712...246,526,530
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Sphk1
sphingosine kinase 1
multiple interactions
EXP
Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of SPHK1 mRNA]
CTD
PMID:16415329
NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240
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Tac1
tachykinin, precursor 1
increases expression
ISO
Ranitidine results in increased expression of TAC1 protein
CTD
PMID:12495560
NCBI chr 4:35,679,183...35,687,180
Ensembl chr 4:35,679,704...35,687,178
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Tfrc
transferrin receptor
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of TFRC mRNA; Heparin inhibits the reaction [[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of TFRC mRNA]
CTD
PMID:16401727
NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
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Tnf
tumor necrosis factor
multiple interactions
ISO EXP
Ranitidine inhibits the reaction [Histamine inhibits the reaction [IL18 protein results in increased expression of TNF protein]]; Ranitidine inhibits the reaction [Histamine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]] [IFNG protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Ranitidine; Ranitidine inhibits the reaction [Aspirin results in increased expression of TNF protein]; Ranitidine inhibits the reaction [Capsaicin results in increased expression of TNF protein]; Ranitidine inhibits the reaction [Indomethacin results in increased expression of TNF protein]; Ranitidine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]
CTD
PMID:11752121 PMID:12023551 PMID:12538815 PMID:15265675 PMID:17698507 PMID:19362101 PMID:28648817 PMID:29523851 PMID:30885738 More...
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnfaip6
TNF alpha induced protein 6
multiple interactions
EXP
Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of TNFAIP6 mRNA]
CTD
PMID:16415329
NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649
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Tnfrsf12a
TNF receptor superfamily member 12A
multiple interactions
EXP
Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of TNFRSF12A mRNA]
CTD
PMID:16415329
NCBI chr10:12,707,077...12,709,071
Ensembl chr10:12,689,890...12,709,045
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Tpm3
tropomyosin 3
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of TPM3 mRNA
CTD
PMID:16415329
NCBI chr 2:175,517,198...175,545,014
Ensembl chr 2:175,517,226...175,545,013
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Trak2
trafficking kinesin protein 2
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of TRAK2 mRNA
CTD
PMID:16415329
NCBI chr 9:60,348,531...60,414,036
Ensembl chr 9:60,350,012...60,413,996
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Ube2b
ubiquitin-conjugating enzyme E2B
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of UBE2B mRNA
CTD
PMID:16415329
NCBI chr10:36,248,434...36,263,379
Ensembl chr10:36,248,438...36,264,665
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Vegfa
vascular endothelial growth factor A
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of VEGFA mRNA
CTD
PMID:16415329
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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Zbtb10
zinc finger and BTB domain containing 10
multiple interactions
EXP
[Lipopolysaccharides co-treated with Ranitidine] results in increased expression of ZBTB10 mRNA
CTD
PMID:16415329
NCBI chr 2:92,475,254...92,509,892
Ensembl chr 2:92,479,014...92,512,515
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Zfyve27
zinc finger FYVE-type containing 27
multiple interactions
EXP
Ranitidine promotes the reaction [Lipopolysaccharides results in increased expression of ZFYVE27 mRNA]
CTD
PMID:16415329
NCBI chr 1:240,979,831...241,003,193
Ensembl chr 1:240,979,842...241,003,193
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Pkm
pyruvate kinase M1/2
multiple interactions
ISO
Glucose deficiency promotes the reaction [SAICAR binds to and results in increased activity of PKM protein]
CTD
PMID:23086999
NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
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Acat1
acetyl-CoA acetyltransferase 1
multiple interactions
ISO
sarpogrelate inhibits the reaction [Serotonin results in increased expression of ACAT1 protein]; sarpogrelate metabolite inhibits the reaction [Serotonin results in increased expression of ACAT1 protein]
CTD
PMID:16157345
NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855
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Adipoq
adiponectin, C1Q and collagen domain containing
increases expression
ISO
sarpogrelate results in increased expression of ADIPOQ protein
CTD
PMID:18235151
NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
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Adra1a
adrenoceptor alpha 1A
multiple interactions
ISO
sarpogrelate inhibits the reaction [Prazosin binds to ADRA1A protein]
CTD
PMID:11937776
NCBI chr15:40,830,125...40,935,902
Ensembl chr15:40,832,534...40,927,500
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Adra1b
adrenoceptor alpha 1B
multiple interactions
ISO
sarpogrelate inhibits the reaction [Prazosin binds to ADRA1B protein]
CTD
PMID:11937776
NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919
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Adra1d
adrenoceptor alpha 1D
multiple interactions
ISO
sarpogrelate inhibits the reaction [Prazosin binds to ADRA1D protein]
CTD
PMID:11937776
NCBI chr 3:118,793,356...118,809,354
Ensembl chr 3:118,793,346...118,809,354
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Akt1
AKT serine/threonine kinase 1
multiple interactions
ISO
[sarpogrelate results in increased activity of AKT1 protein] inhibits the reaction [Serotonin results in increased ubiquitination of and results in increased degradation of IRS1 protein]
CTD
PMID:22975078
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Atp2a2
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
affects expression
EXP
sarpogrelate affects the expression of ATP2A2 mRNA; sarpogrelate affects the expression of ATP2A2 protein
CTD
PMID:18088389
NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions
ISO
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased expression of BAX protein]; Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased expression of BAX protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]] Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of BAX protein]]
CTD
PMID:34560070 PMID:35202708
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
multiple interactions
ISO
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]; sarpogrelate inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]] [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]; sarpogrelate inhibits the reaction [Cisplatin results in decreased expression of BCL2 protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in decreased expression of BCL2 protein]]
CTD
PMID:34560070 PMID:35202708
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Casp3
caspase 3
multiple interactions
ISO
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]] [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP3 protein]]
CTD
PMID:34560070 PMID:35202708
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp9
caspase 9
multiple interactions
ISO
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP9 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP9 protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP9 protein]] [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]; Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP9 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP9 protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased cleavage of CASP9 protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in increased cleavage of CASP9 protein]]
CTD
PMID:34560070 PMID:35202708
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Ccl2
C-C motif chemokine ligand 2
multiple interactions decreases expression
ISO
sarpogrelate inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased expression of CCL2 protein] sarpogrelate results in decreased expression of CCL2 protein
CTD
PMID:18235151 PMID:26824242
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
decreases activity multiple interactions
ISO
sarpogrelate metabolite results in decreased activity of CYP2D6 protein; sarpogrelate results in decreased activity of CYP2D6 protein sarpogrelate inhibits the reaction [CYP2D6 protein results in decreased methylation of Dextromethorphan]; sarpogrelate metabolite inhibits the reaction [CYP2D6 protein results in decreased methylation of Dextromethorphan]
CTD
PMID:24167220
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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Ddc
dopa decarboxylase
multiple interactions
ISO
sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of DDC mRNA]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of DDC protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased expression of DDC protein] [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in increased expression of DDC mRNA]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of DDC mRNA]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of DDC protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased expression of DDC protein]
CTD
PMID:34560070 PMID:35202708
NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208
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Dnm1l
dynamin 1-like
multiple interactions
ISO
Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of DNM1L protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of DNM1L protein]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of DNM1L protein]] Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of DNM1L protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of DNM1L protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in increased expression of DNM1L protein]]
CTD
PMID:35202708
NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
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Fabp1
fatty acid binding protein 1
multiple interactions
ISO
sarpogrelate inhibits the reaction [Oxygen deficiency results in increased expression of FABP1 protein]
CTD
PMID:24107419
NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788
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Fis1
fission, mitochondrial 1
multiple interactions
ISO
Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of FIS1 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of FIS1 protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in increased expression of FIS1 protein]] Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of FIS1 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of FIS1 protein]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of FIS1 protein]]
CTD
PMID:35202708
NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377
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Gpt
glutamic--pyruvic transaminase
multiple interactions
ISO
Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased activity of GPT protein]]
CTD
PMID:35202708
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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Htr1b
5-hydroxytryptamine receptor 1B
multiple interactions
EXP
sarpogrelate inhibits the reaction [Iodocyanopindolol binds to HTR1B protein]; sarpogrelate metabolite inhibits the reaction [Iodocyanopindolol binds to HTR1B protein]
CTD
PMID:8937629
NCBI chr 8:82,513,572...82,534,670
Ensembl chr 8:82,517,360...82,534,549
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Htr2a
5-hydroxytryptamine receptor 2A
multiple interactions affects binding
ISO EXP
sarpogrelate binds to and results in decreased activity of HTR2A protein; sarpogrelate binds to and results in decreased activity of HTR2A protein mutant form; sarpogrelate metabolite binds to and results in decreased activity of HTR2A protein sarpogrelate binds to HTR2A protein; sarpogrelate metabolite binds to HTR2A protein
CTD
PMID:8937629 PMID:16974069 PMID:17031071 PMID:19672037
NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
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Htr2c
5-hydroxytryptamine receptor 2C
affects binding
ISO
sarpogrelate binds to HTR2C protein
CTD
PMID:16880620
NCBI chr X:110,640,777...110,870,288
Ensembl chr X:110,641,153...110,870,287
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Icam1
intercellular adhesion molecule 1
multiple interactions
ISO
sarpogrelate inhibits the reaction [Glucose results in increased expression of ICAM1 protein]
CTD
PMID:23111892
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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Il18
interleukin 18
decreases expression
ISO
sarpogrelate results in decreased expression of IL18 protein
CTD
PMID:15080020
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
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Il1b
interleukin 1 beta
multiple interactions
ISO
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased secretion of IL1B protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased secretion of IL1B protein] [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased expression of IL1B protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased expression of IL1B protein]
CTD
PMID:34560070
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il6
interleukin 6
multiple interactions
ISO
sarpogrelate inhibits the reaction [Serotonin results in increased expression of and results in increased secretion of IL6 protein]
CTD
PMID:11076827
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Irs1
insulin receptor substrate 1
multiple interactions
ISO
[sarpogrelate results in increased activity of AKT1 protein] inhibits the reaction [Serotonin results in increased ubiquitination of and results in increased degradation of IRS1 protein]
CTD
PMID:22975078
NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
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Kdr
kinase insert domain receptor
multiple interactions
ISO
sarpogrelate inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of KDR protein]
CTD
PMID:27097221
NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018
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Maoa
monoamine oxidase A
multiple interactions
ISO
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in increased expression of MAOA mRNA]; [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased expression of MAOA protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of MAOA protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of MAOA mRNA]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of MAOA protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased expression of MAOA protein]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in increased expression of MAOA protein]]
CTD
PMID:34560070 PMID:35202708
NCBI chr X:6,032,172...6,098,308
Ensembl chr X:6,030,795...6,099,593
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Mfn1
mitofusin 1
multiple interactions
ISO
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN1 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN1 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN1 protein] Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN1 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN1 protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in decreased expression of MFN1 protein]]
CTD
PMID:35202708
NCBI chr 2:115,313,380...115,359,651
Ensembl chr 2:115,313,401...115,359,640
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Mmp13
matrix metallopeptidase 13
multiple interactions
EXP
sarpogrelate inhibits the reaction [Oxygen deficiency results in increased expression of MMP13 mRNA]
CTD
PMID:25931318
NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
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Mt-atp6
mitochondrially encoded ATP synthase membrane subunit 6
multiple interactions
ISO
Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ATP6 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ATP6 protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in decreased expression of ATP6 protein]] Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ATP6 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ATP6 protein]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in decreased expression of ATP6 protein]]
CTD
PMID:35202708
NCBI chr MT:7,919...8,599 NCBI chr MT:7,919...8,599 NCBI chr MT:7,919...8,599
Ensembl chr MT:7,919...8,599
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Mt-cyb
mitochondrially encoded cytochrome b
multiple interactions
ISO
Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYTB protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYTB protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYTB protein]] Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYTB protein]]; sarpogrelate promotes the reaction [Carbidopa inhibits the reaction [Carbon Tetrachloride results in decreased expression of CYTB protein]]
CTD
PMID:35202708
NCBI chr MT:14,136...15,278 NCBI chr MT:14,136...15,278 NCBI chr MT:14,136...15,278
Ensembl chr MT:14,136...15,278
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Mt-nd1
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1
multiple interactions
ISO
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in decreased expression of ND1 protein]; Carbidopa promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ND1 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ND1 protein] Clorgyline promotes the reaction [sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ND1 protein]]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in decreased expression of ND1 protein]; sarpogrelate promotes the reaction [Clorgyline inhibits the reaction [Carbon Tetrachloride results in decreased expression of ND1 protein]]
CTD
PMID:35202708
NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694 NCBI chr MT:2,740...3,694
Ensembl chr MT:2,740...3,694
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Mtor
mechanistic target of rapamycin kinase
multiple interactions
ISO
sarpogrelate inhibits the reaction [Palmitic Acid results in increased activity of MTOR protein]; sarpogrelate inhibits the reaction [Serotonin results in increased activity of MTOR protein]
CTD
PMID:27133527
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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Nos3
nitric oxide synthase 3
multiple interactions
EXP
sarpogrelate promotes the reaction [Oxygen deficiency results in increased expression of NOS3 protein]
CTD
PMID:25931318
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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Pecam1
platelet and endothelial cell adhesion molecule 1
multiple interactions
ISO
sarpogrelate inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of PECAM1 protein]
CTD
PMID:27097221
NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
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Pln
phospholamban
affects expression
EXP
sarpogrelate affects the expression of PLN mRNA; sarpogrelate affects the expression of PLN protein
CTD
PMID:18088389
NCBI chr20:32,629,537...32,639,559
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
EXP
sarpogrelate inhibits the reaction [Serotonin results in increased expression of PTGS2 mRNA]; sarpogrelate inhibits the reaction [Serotonin results in increased expression of PTGS2 protein]
CTD
PMID:21262218
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased phosphorylation of RELA protein]
CTD
PMID:34560070
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Serpine2
serpin family E member 2
decreases expression multiple interactions
ISO
sarpogrelate results in decreased expression of SERPINE2 mRNA sarpogrelate inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of SERPINE2 protein]; sarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased expression of SERPINE2 mRNA]; sarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein]
CTD
PMID:24107419 PMID:27097221
NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826
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Slc2a1
solute carrier family 2 member 1
affects expression
EXP
sarpogrelate affects the expression of SLC2A1 protein
CTD
PMID:21183729
NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
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Slc2a4
solute carrier family 2 member 4
affects expression
EXP
sarpogrelate affects the expression of SLC2A4 protein
CTD
PMID:21183729
NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
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Sorl1
sortilin related receptor 1
multiple interactions
ISO
sarpogrelate inhibits the reaction [Serotonin results in increased expression of SORL1 mRNA]
CTD
PMID:24650663
NCBI chr 8:42,341,704...42,504,435
Ensembl chr 8:42,341,704...42,504,513
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Stat3
signal transducer and activator of transcription 3
multiple interactions
ISO
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased phosphorylation of STAT3 protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased phosphorylation of STAT3 protein]
CTD
PMID:34560070
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Tgfb1
transforming growth factor, beta 1
multiple interactions
ISO
sarpogrelate inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TGFB1 protein]; sarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased expression of SERPINE2 mRNA]; sarpogrelate inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein]
CTD
PMID:24107419 PMID:27097221
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Tnf
tumor necrosis factor
multiple interactions
ISO
[sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased secretion of TNF protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased secretion of TNF protein] [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Cisplatin results in increased expression of TNF protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased expression of TNF protein]
CTD
PMID:34560070
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tph1
tryptophan hydroxylase 1
multiple interactions
ISO
sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of TPH1 mRNA]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of TPH1 protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased expression of TPH1 protein] [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in increased expression of TPH1 mRNA]; [sarpogrelate co-treated with Carbidopa] inhibits the reaction [Carbon Tetrachloride results in increased expression of TPH1 protein]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of TPH1 mRNA]; sarpogrelate inhibits the reaction [Carbon Tetrachloride results in increased expression of TPH1 protein]; sarpogrelate inhibits the reaction [Cisplatin results in increased expression of TPH1 protein]
CTD
PMID:34560070 PMID:35202708
NCBI chr 1:97,157,375...97,178,415
Ensembl chr 1:97,157,409...97,178,344
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Ugt1a5
UDP glucuronosyltransferase family 1 member A5
increases glucuronidation
ISO
UGT1A4 protein results in increased glucuronidation of sarpogrelate metabolite
CTD
PMID:23704698
NCBI chr 9:88,762,250...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Ugt1a9
UDP glucuronosyltransferase family 1 member A9
increases glucuronidation
ISO
UGT1A9 protein results in increased glucuronidation of sarpogrelate metabolite
CTD
PMID:23704698
NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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Vcam1
vascular cell adhesion molecule 1
multiple interactions
ISO
sarpogrelate inhibits the reaction [[Glucose co-treated with Serotonin] results in increased expression of VCAM1 protein]
CTD
PMID:22785018
NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions
ISO
[Oleanolic Acid analog binds to Succinic Acid] which results in increased expression of BAX mRNA; [Oleanolic Acid analog binds to Succinic Acid] which results in increased expression of BAX protein
CTD
PMID:31401087
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2l1
Bcl2-like 1
multiple interactions
ISO
[Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of BCL2L1 mRNA; [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of BCL2L1 protein
CTD
PMID:31401087
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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Col2a1
collagen type II alpha 1 chain
multiple interactions
EXP
[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Succinic Acid; [geniposide co-treated with phellodendrine co-treated with magnoflorine co-treated with Chlorogenic Acid co-treated with crocin co-treated with Flavonoids co-treated with Berberine Alkaloids] inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Succinic Acid]; Dexamethasone inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Succinic Acid]; huang-lien-chieh-tu-tang inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Succinic Acid]
CTD
PMID:24709313
NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546
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Dek
DEK proto-oncogene
multiple interactions
ISO
DEK protein affects the chemical synthesis of and affects the secretion of Succinic Acid
CTD
PMID:28558019
NCBI chr17:17,580,804...17,602,825
Ensembl chr17:17,580,843...17,602,808
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Ercc6
ERCC excision repair 6, chromatin remodeling factor
increases abundance
ISO
ERCC6 gene mutant form results in increased abundance of Succinic Acid
CTD
PMID:25440059
NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587
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Hif1a
hypoxia inducible factor 1 subunit alpha
multiple interactions
EXP
Succinic Acid inhibits the reaction [Rotenone affects the expression of HIF1A protein]
CTD
PMID:16034640
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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Lepr
leptin receptor
affects abundance
ISO
LEPR affects the abundance of Succinic Acid
CTD
PMID:20567778
NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
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Myc
MYC proto-oncogene, bHLH transcription factor
multiple interactions
ISO
[Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of MYC mRNA; [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of MYC protein
CTD
PMID:31401087
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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Nfkb1
nuclear factor kappa B subunit 1
multiple interactions
ISO
[Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of NFKB1 mRNA
CTD
PMID:31401087
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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Nr4a1
nuclear receptor subfamily 4, group A, member 1
multiple interactions
ISO
[Glycerol co-treated with Succinic Acid co-treated with Glucose-6-Phosphate co-treated with Pantothenic Acid co-treated with Niacinamide] results in increased expression of NR4A1 mRNA
CTD
PMID:20505214
NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
[Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of PTGS2 mRNA; [Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of PTGS2 protein
CTD
PMID:31401087
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
[Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of RELA mRNA
CTD
PMID:31401087
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Slc13a3
solute carrier family 13 member 3
affects binding
ISO EXP
Succinic Acid binds to SLC13A3 protein
CTD
PMID:12397032
NCBI chr 3:154,141,878...154,204,604
Ensembl chr 3:154,141,872...154,204,606
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Slc22a25
solute carrier family 22, member 25
multiple interactions
EXP
Succinic Acid affects the reaction [SLC22A19 protein affects the transport of estrone sulfate]; Succinic Acid inhibits the reaction [SLC22A9 protein affects the transport of estrone sulfate]
CTD
PMID:16079298 PMID:18441515
NCBI chr 1:205,338,698...205,498,486
Ensembl chr 1:205,338,699...205,433,085
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Slc22a6
solute carrier family 22 member 6
multiple interactions increases activity
ISO
[Succinic Acid results in increased activity of SLC22A6 protein] which results in increased uptake of p-Aminohippuric Acid
CTD
PMID:36958672
NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
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Slc22a8
solute carrier family 22 member 8
multiple interactions increases activity
ISO
[Succinic Acid results in increased activity of SLC22A8 protein] which results in increased uptake of p-Aminohippuric Acid
CTD
PMID:36958672
NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
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Slco1a4
solute carrier organic anion transporter family, member 1a4
affects abundance
ISO
SLCO1A4 protein affects the abundance of Succinic Acid
CTD
PMID:21561886
NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
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Stat3
signal transducer and activator of transcription 3
multiple interactions
ISO
[Oleanolic Acid analog binds to Succinic Acid] which results in decreased expression of STAT3 mRNA
CTD
PMID:31401087
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Bche
butyrylcholinesterase
increases response to substance increases metabolic processing increases hydrolysis affects hydrolysis multiple interactions decreases abundance decreases hydrolysis affects response to substance
ISO
BCHE gene mutant form results in increased susceptibility to Succinylcholine; BCHE gene polymorphism results in increased susceptibility to Succinylcholine; BCHE protein mutant form results in increased susceptibility to Succinylcholine BCHE protein results in increased metabolism of Succinylcholine BCHE protein results in increased hydrolysis of Succinylcholine BCHE protein mutant form affects the hydrolysis of Succinylcholine [Dichlorvos results in decreased activity of BCHE protein] which results in increased susceptibility to Succinylcholine; Insecticides inhibits the reaction [BCHE protein results in increased metabolism of Succinylcholine]; Organophosphorus Compounds inhibits the reaction [BCHE protein results in increased metabolism of Succinylcholine]; Succinylcholine inhibits the reaction [BCHE protein results in increased hydrolysis of butyrylcholine] BCHE protein results in decreased abundance of Succinylcholine BCHE protein mutant form results in decreased hydrolysis of Succinylcholine BCHE affects the susceptibility to Succinylcholine; BCHE gene mutant form affects the susceptibility to Succinylcholine; BCHE gene polymorphism affects the susceptibility to Succinylcholine; BCHE protein affects the susceptibility to Succinylcholine
CTD
PMID:726855 PMID:900467 PMID:987736 PMID:1058931 PMID:1147298 PMID:1218148 PMID:1218179 PMID:1734774 PMID:1781528 PMID:2249680 PMID:2432808 PMID:4319258 PMID:4698763 PMID:4728581 PMID:4746059 PMID:4850696 PMID:4985882 PMID:4998912 PMID:5365519 PMID:5412891 PMID:5488351 PMID:5673118 PMID:6465587 PMID:6859614 PMID:6928942 PMID:7069741 PMID:7294376 PMID:7378868 PMID:7793179 PMID:8179139 PMID:9110359 PMID:12190811 PMID:12881446 PMID:15688329 PMID:15826794 PMID:16788378 PMID:16884476 PMID:18075469 PMID:18399847 PMID:18555211 PMID:21029050 PMID:21228368 PMID:25054547 More...
NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
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Chrna4
cholinergic receptor nicotinic alpha 4 subunit
multiple interactions
ISO
Succinylcholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]
CTD
PMID:14645658
NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957
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Chrnb2
cholinergic receptor nicotinic beta 2 subunit
multiple interactions
ISO
Succinylcholine inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]
CTD
PMID:14645658
NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
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Mb
myoglobin
increases secretion
ISO
Succinylcholine results in increased secretion of MB protein
CTD
PMID:8217179
NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383
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Pklr
pyruvate kinase L/R
decreases activity
EXP
suxibuzone results in decreased activity of PKLR protein
CTD
PMID:3107799
NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870
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Casp3
caspase 3
multiple interactions
ISO
geranylgeranylacetone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of and results in increased cleavage of CASP3 protein]
CTD
PMID:34732784
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cdh1
cadherin 1
multiple interactions
ISO
geranylgeranylacetone inhibits the reaction [Bleomycin results in decreased expression of CDH1 mRNA]; geranylgeranylacetone inhibits the reaction [Bleomycin results in decreased expression of CDH1 protein] geranylgeranylacetone inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 mRNA]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]
CTD
PMID:37307957
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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Col1a1
collagen type I alpha 1 chain
multiple interactions
ISO
geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of COL1A1 mRNA]; geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of COL1A1 protein]
CTD
PMID:37307957
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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Col1a2
collagen type I alpha 2 chain
multiple interactions
ISO
geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of COL1A2 mRNA]; geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of COL1A2 protein]
CTD
PMID:37307957
NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
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Dlg1
discs large MAGUK scaffold protein 1
increases expression multiple interactions
ISO
geranylgeranylacetone results in increased expression of DLG1 mRNA; geranylgeranylacetone results in increased expression of DLG1 protein geranylgeranylacetone promotes the reaction [[HSF1 protein binds to DLG1 promoter] which results in increased expression of DLG1 mRNA]; Niacinamide inhibits the reaction [geranylgeranylacetone results in increased expression of DLG1 mRNA]; resveratrol promotes the reaction [geranylgeranylacetone results in increased expression of DLG1 mRNA]
CTD
PMID:21232033
NCBI chr11:68,911,883...69,103,230
Ensembl chr11:68,911,883...69,102,689
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Edn1
endothelin 1
decreases expression
EXP
geranylgeranylacetone results in decreased expression of EDN1 protein
CTD
PMID:16324314
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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Fn1
fibronectin 1
multiple interactions
ISO
geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of FN1 mRNA]; geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of FN1 protein]
CTD
PMID:37307957
NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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Hsf1
heat shock transcription factor 1
multiple interactions affects response to substance increases expression
ISO
geranylgeranylacetone promotes the reaction [[HSF1 protein binds to DLG1 promoter] which results in increased expression of DLG1 mRNA] HSF1 protein affects the susceptibility to geranylgeranylacetone geranylgeranylacetone results in increased expression of HSF1 protein
CTD
PMID:17189318 PMID:21232033
NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
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Hspa1a
heat shock protein family A (Hsp70) member 1A
multiple interactions
ISO
geranylgeranylacetone promotes the reaction [Bleomycin results in increased expression of HSPA1A mRNA]; geranylgeranylacetone promotes the reaction [Ethanol results in increased expression of HSPA1A protein] geranylgeranylacetone promotes the reaction [TGFB1 protein results in increased expression of HSPA1A mRNA]; geranylgeranylacetone promotes the reaction [TGFB1 protein results in increased expression of HSPA1A protein]
CTD
PMID:17189318 PMID:37307957
NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227
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Hspa1b
heat shock protein family A (Hsp70) member 1B
multiple interactions
ISO
[Tetrachlorodibenzodioxin co-treated with geranylgeranylacetone] results in increased expression of HSPA1B mRNA; [Tetrachlorodibenzodioxin co-treated with geranylgeranylacetone] results in increased expression of HSPA1B protein; geranylgeranylacetone promotes the reaction [Bleomycin results in increased expression of HSPA1B mRNA] geranylgeranylacetone promotes the reaction [TGFB1 protein results in increased expression of HSPA1B mRNA]; geranylgeranylacetone promotes the reaction [TGFB1 protein results in increased expression of HSPA1B protein]
CTD
PMID:15340226 PMID:37307957
NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240 Ensembl chr20:3,856,006...3,873,240
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Kcna5
potassium voltage-gated channel subfamily A member 5
increases expression
ISO
geranylgeranylacetone results in increased expression of KCNA5 protein
CTD
PMID:21232033
NCBI chr 4:159,354,689...159,358,173
Ensembl chr 4:159,350,097...159,357,697
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Map3k5
mitogen-activated protein kinase kinase kinase 5
multiple interactions
ISO
geranylgeranylacetone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of MAP3K5 protein]
CTD
PMID:34732784
NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
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Nox4
NADPH oxidase 4
multiple interactions
ISO
geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of NOX4 mRNA]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of NOX4 protein] geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of NOX4 mRNA]
CTD
PMID:37307957
NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
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Parp1
poly (ADP-ribose) polymerase 1
multiple interactions
ISO
geranylgeranylacetone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased cleavage of PARP1 protein]
CTD
PMID:34732784
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
geranylgeranylacetone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of RELA protein]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of RELA mRNA]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of RELA protein] geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of RELA mRNA]
CTD
PMID:34732784 PMID:37307957
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Tgfb1
transforming growth factor, beta 1
multiple interactions
ISO
geranylgeranylacetone inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 mRNA]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of NOX4 mRNA]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of NOX4 protein]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of RELA mRNA]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of RELA protein]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of VIM mRNA]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]; geranylgeranylacetone promotes the reaction [TGFB1 protein results in increased expression of HSPA1A mRNA]; geranylgeranylacetone promotes the reaction [TGFB1 protein results in increased expression of HSPA1A protein]; geranylgeranylacetone promotes the reaction [TGFB1 protein results in increased expression of HSPA1B mRNA]; geranylgeranylacetone promotes the reaction [TGFB1 protein results in increased expression of HSPA1B protein]
CTD
PMID:37307957
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Txn1
thioredoxin 1
multiple interactions
ISO
geranylgeranylacetone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TXN mRNA]; geranylgeranylacetone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TXN protein]
CTD
PMID:34732784
NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
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Vim
vimentin
multiple interactions
ISO
geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of VIM mRNA]; geranylgeranylacetone inhibits the reaction [Bleomycin results in increased expression of VIM protein] geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of VIM mRNA]; geranylgeranylacetone inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]
CTD
PMID:37307957
NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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Endog
endonuclease G
multiple interactions
EXP
[Hydrogen Peroxide co-treated with 2-thiomalic acid] affects the localization of ENDOG protein
CTD
PMID:16407272
NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932
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Gpx1
glutathione peroxidase 1
decreases activity
ISO
2-thiomalic acid results in decreased activity of GPX1 protein
CTD
PMID:21892612
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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Tnf
tumor necrosis factor
multiple interactions
ISO
2-thiomalic acid promotes the reaction [Asbestos, Crocidolite results in increased secretion of TNF protein]
CTD
PMID:10486238
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Kcnh2
potassium voltage-gated channel subfamily H member 2
decreases activity
ISO
thiaton results in decreased activity of KCNH2 protein
CTD
PMID:28551711
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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Mpo
myeloperoxidase
multiple interactions
EXP
thiaton inhibits the reaction [Indomethacin results in increased activity of MPO protein]
CTD
PMID:11855677
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Nos2
nitric oxide synthase 2
multiple interactions
EXP
thiaton inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]
CTD
PMID:11855677
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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