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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:leptophos
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Accession:CHEBI:82137 term browser browse the term
Definition:A racemate comprising equimolar amounts of (R)- and (S)-leptophos. It is an organothiophosphate insecticide that shows neurotoxic effect in humans.
Synonyms:exact_synonym: rac-O-(4-bromo-2,5-dichlorophenyl) O-methyl phenylphosphonothioate
 related_synonym: (RS)-O-(4-bromo-2,5-dichlorophenyl) O-methyl phenylphosphonothioate;   (RS)-leptophos;   Abar;   Formula=C13H10BrCl2O2PS;   Fosvel;   K62-105;   MBCP;   NK 711;   OMS 1438;   Oleophosvel;   Phosvel;   VCS 5-D;   VCS-506;   Velsicol 506;   Velsicol VCS-506;   racemic leptophos
 xref: AGR:IND89026816;   CAS:21609-90-5;   FooDB:FDB008471;   HMDB:HMDB0031798;   KEGG:C19003
 xref_mesh: MESH:D010773
 xref: PMID:12537969;   PMID:12742374;   PMID:15492452;   PMID:21152278;   PMID:21428349;   PMID:21432420;   PMID:2430007;   PMID:2431660;   PMID:2449553;   PMID:2472490;   PMID:2473232;   PMID:2481746;   PMID:318517;   PMID:4369913;   PMID:4841433;   PMID:6178187;   PMID:6188603;   PMID:64240;   PMID:72768;   PMID:7685784;   PMID:8720167;   PMID:91399;   PMID:91400;   PMID:9198007;   PPDB:1520;   Pesticides:leptophos;   Reaxys:2152663;   Wikipedia:Leptophos


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leptophos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO Leptophos metabolite results in decreased activity of ACHE protein; Leptophos results in decreased activity of ACHE protein CTD PMID:33844597 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Ar androgen receptor multiple interactions ISO Dihydrotestosterone inhibits the reaction [Leptophos results in increased activity of AR protein] CTD PMID:15064155 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Esr1 estrogen receptor 1 increases activity ISO Leptophos results in increased activity of ESR1 protein CTD PMID:15064155 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 increases activity ISO Leptophos results in increased activity of ESR2 protein CTD PMID:15064155 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Leptophos binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO Leptophos results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906 		JBrowse link
G Tp53 tumor protein p53 affects activity ISO Leptophos metabolite affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        aetiopathogenetic role 19166
          neurotoxin 18155
            leptophos 7
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      chalcogen 19513
                        oxygen atom 19488
                          oxygen molecular entity 19488
                            hydroxides 19299
                              oxoacid 18736
                                pnictogen oxoacid 13211
                                  phosphorus oxoacid 12414
                                    phosphorus oxoacid derivative 11762
                                      phosphonic acid derivative 2352
                                        phosphonate 184
                                          organic phosphonate 184
                                            O-(4-bromo-2,5-dichlorophenyl) O-methyl phenylphosphonothioate 7
                                              (R)-leptophos 7
                                                leptophos 7
paths to the root