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nandrolone - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:nandrolone
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Accession:CHEBI:7466 term browser browse the term
Definition:A 3-oxo Delta(4)-steroid that is estr-4-en-3-one substituted by a beta-hydroxy group at position 17.
Synonyms:related_synonym: (17beta)-17-hydroxyestr-4-en-3-one;   17beta-hydroxy-19-nor-4-androsten-3-one;   17beta-hydroxy-4-estren-3-one;   17beta-hydroxyestr-4-en-3-one;   19-Norandrostenolone;   19-Nortestosterone;   4-estren-17beta-ol-3-one;   Formula=C18H26O2;   InChI=1S/C18H26O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h10,13-17,20H,2-9H2,1H3/t13-,14+,15+,16-,17-,18-/m0/s1;   InChIKey=NPAGDVCDWIYMMC-IZPLOLCNSA-N;   SMILES=[H][C@]12CCC(=O)C=C1CC[C@]1([H])[C@]2([H])CC[C@]2(C)[C@@H](O)CC[C@@]12[H]
 xref: Beilstein:4690380;   CAS:434-22-0;   DrugBank:DB00984;   Drug_Central:1879;   Gmelin:1228044;   HMDB:HMDB0002725;   KEGG:C07254;   KEGG:D08250
 xref_mesh: MESH:D009277
 xref: PMID:11888015;   PMID:19055689;   PMID:20020363;   PMID:24405322;   Reaxys:2055849;   VSDB:1861;   Wikipedia:Nandrolone

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show annotations for term's descendants           Sort by:
nandrolone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd86 CD86 molecule multiple interactions ISO Nandrolone promotes the reaction [endotoxin, Escherichia coli results in increased expression of CD86 protein] CTD PMID:28412309 NCBI chr11:77,647,565...77,706,178
Ensembl chr11:64,163,828...64,200,818 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions ISO Nandrolone inhibits the reaction [CYP19A1 protein affects the metabolism of Androstenedione] CTD PMID:12628686 NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Nandrolone binds to and results in increased activity of ESR1 protein CTD PMID:29162470 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 affects binding EXP 19-nortestosterone binds to Esr2 protein RGD PMID:9048584 RGD:8694130 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 increases expression ISO Nandrolone results in increased expression of GREB1 mRNA CTD PMID:35307500 NCBI chr 6:45,169,289...45,321,973
Ensembl chr 6:39,440,504...39,581,633 		JBrowse link
G Pgr progesterone receptor increases expression ISO Nandrolone results in increased expression of PGR mRNA CTD PMID:35307500 NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Rack1 receptor for activated C kinase 1 increases expression
multiple interactions 		ISO Nandrolone results in increased expression of RACK1 mRNA; Nandrolone results in increased expression of RACK1 protein
Flutamide inhibits the reaction [Nandrolone results in increased expression of RACK1 mRNA] 		CTD PMID:28412309 NCBI chr10:33,668,560...33,676,031
Ensembl chr10:33,169,169...33,174,975 		JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Nandrolone inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268 		JBrowse link
G Tff1 trefoil factor 1 increases expression ISO Nandrolone results in increased expression of TFF1 mRNA CTD PMID:35307500 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Nandrolone promotes the reaction [endotoxin, Escherichia coli results in increased expression of TNF protein] CTD PMID:28412309 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
nandrolone phenpropionate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions
affects localization 		ISO nandrolone phenpropionate binds to and results in increased activity of AR protein
nandrolone phenpropionate affects the localization of AR protein 		CTD PMID:28478275 NCBI chr  X:67,135,317...67,304,476
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20856
    chemical entity 20854
      group 20798
        organic group 19534
          3-oxo-Delta(4)-steroid group 9254
            3-oxo-Delta(4) steroid 9254
              nandrolone 11
                nandrolone phenpropionate 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 20856
    subatomic particle 20854
      composite particle 20854
        hadron 20854
          baryon 20854
            nucleon 20854
              atomic nucleus 20854
                atom 20854
                  main group element atom 20777
                    p-block element atom 20777
                      carbon group element atom 20710
                        carbon atom 20704
                          organic molecular entity 20704
                            heteroorganic entity 20215
                              organochalcogen compound 19902
                                organooxygen compound 19804
                                  carbonyl compound 19435
                                    ketone 17451
                                      oxo steroid 10638
                                        3-oxo steroid 10017
                                          3-oxo-Delta(4) steroid 9254
                                            nandrolone 11
                                              nandrolone phenpropionate 1
paths to the root