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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tetraethylenepentamine
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Accession:CHEBI:49798 term browser browse the term
Definition:A polyazaalkane that has formula 189.30192.
Synonyms:exact_synonym: N-(2-aminoethyl)-N'-{2-[(2-aminoethyl)amino]ethyl}ethane-1,2-diamine
 related_synonym: 1,11-Diamino-3,6,9-triazaundecane;   1,4,7,10,13-pentaazatridecane;   3,6,9-triazaundecamethylenediamine;   3,6,9-triazaundecane-1,11-diamine;   Formula=C8H23N5;   InChI=1S/C8H23N5/c9-1-3-11-5-7-13-8-6-12-4-2-10/h11-13H,1-10H2;   InChIKey=FAGUFWYHJQFNRV-UHFFFAOYSA-N;   N-(2-aminoethyl)-N'-[2-[(2-aminoethyl)amino]ethyl]-1,2-ethanediamine;   SMILES=NCCNCCNCCNCCN;   TEPA;   Tetraethylenpentamin;   tetren
 alt_id: CHEBI:35007;   CHEBI:49797
 xref: Beilstein:506966;   CAS:112-57-2;   Gmelin:51196;   KEGG:C14690;   LINCS:LSM-5530
 xref_mesh: MESH:C034269



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tetraethylenepentamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atox1 antioxidant 1 copper chaperone increases expression ISO tetraethylenepentamine results in increased expression of ATOX1 protein CTD PMID:24343031 NCBI chr11:55,337,463...55,352,034
Ensembl chr11:55,337,467...55,352,065
JBrowse link
G Bnip3 BCL2/adenovirus E1B interacting protein 3 multiple interactions ISO tetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased expression of BNIP3 mRNA] CTD PMID:25100165 NCBI chr 7:138,492,565...138,511,235
Ensembl chr 7:138,492,565...138,511,248
JBrowse link
G Ccs copper chaperone for superoxide dismutase increases expression ISO tetraethylenepentamine results in increased expression of CCS protein CTD PMID:24343031 NCBI chr19:4,875,394...4,889,326
Ensembl chr19:4,875,394...4,889,360
JBrowse link
G Cdh1 cadherin 1 increases expression
multiple interactions
EXP
ISO
tetraethylenepentamine results in increased expression of CDH1 protein
tetraethylenepentamine inhibits the reaction [cobaltous chloride results in decreased expression of CDH1 protein]
CTD PMID:26174737 NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878
JBrowse link
G Cox17 cytochrome c oxidase assembly protein 17, copper chaperone decreases expression ISO tetraethylenepentamine results in decreased expression of COX17 protein CTD PMID:24343031 NCBI chr16:38,167,332...38,173,125
Ensembl chr16:38,167,353...38,182,659
JBrowse link
G Fn1 fibronectin 1 multiple interactions
decreases expression
ISO
EXP
tetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased expression of FN1 mRNA]; tetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased expression of FN1 protein]
tetraethylenepentamine results in decreased expression of FN1 protein
CTD PMID:26174737 NCBI chr 1:71,624,632...71,692,439
Ensembl chr 1:71,624,679...71,692,359
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO tetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased expression of GAPDH mRNA] CTD PMID:25100165 NCBI chr 6:125,138,812...125,143,450
Ensembl chr 6:125,138,678...125,143,430
JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit multiple interactions ISO Copper Sulfate affects the reaction [tetraethylenepentamine affects the localization of HIF1A protein]; tetraethylenepentamine affects the expression of and affects the localization of HIF1A protein; tetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased activity of HIF1A protein]; tetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased expression of and affects the localization of HIF1A protein] CTD PMID:25687434 PMID:26174737 NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304
JBrowse link
G Hif1an hypoxia-inducible factor 1, alpha subunit inhibitor affects localization
multiple interactions
ISO tetraethylenepentamine affects the localization of HIF1AN protein
Copper Sulfate affects the reaction [tetraethylenepentamine affects the localization of HIF1AN protein]; tetraethylenepentamine inhibits the reaction [cobaltous chloride results in decreased expression of HIF1AN protein]
CTD PMID:25687434 PMID:26174737 NCBI chr19:44,551,293...44,564,713
Ensembl chr19:44,551,289...44,564,713
JBrowse link
G Pgk1 phosphoglycerate kinase 1 multiple interactions ISO tetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased expression of PGK1 mRNA] CTD PMID:25100165 NCBI chr  X:105,230,706...105,247,305
Ensembl chr  X:105,230,706...105,247,305
JBrowse link
G Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 1 multiple interactions ISO tetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased expression of SLC2A1 mRNA] CTD PMID:25100165 NCBI chr 4:118,966,001...118,994,527
Ensembl chr 4:118,965,908...118,995,180
JBrowse link
G Snai1 snail family zinc finger 1 multiple interactions
decreases expression
ISO
EXP
tetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased expression of and affects the localization of SNAI1 protein]
tetraethylenepentamine results in decreased expression of SNAI1 protein
CTD PMID:26174737 NCBI chr 2:167,380,115...167,384,734
Ensembl chr 2:167,380,115...167,384,734
JBrowse link
G Twist1 twist basic helix-loop-helix transcription factor 1 multiple interactions
decreases expression
ISO
EXP
tetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased expression of and affects the localization of TWIST1 protein]
tetraethylenepentamine results in decreased expression of TWIST1 protein
CTD PMID:26174737 NCBI chr12:34,007,670...34,009,830
Ensembl chr12:34,007,670...34,009,828
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Copper Sulfate inhibits the reaction [tetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased expression of VEGFA mRNA]]; Copper Sulfate inhibits the reaction [tetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased expression of VEGFA protein]]; tetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased expression of VEGFA mRNA]; tetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased expression of VEGFA protein] CTD PMID:22619252 PMID:25100165 PMID:26174737 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295
JBrowse link
G Vim vimentin multiple interactions ISO tetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased expression of VIM mRNA]; tetraethylenepentamine inhibits the reaction [cobaltous chloride results in increased expression of VIM protein] CTD PMID:26174737 NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22308
    role 22292
      chemical role 21516
        ligand 6904
          chelator 6888
            copper chelator 659
              tetraethylenepentamine 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 22308
    subatomic particle 22302
      composite particle 22302
        hadron 22302
          baryon 22302
            nucleon 22302
              atomic nucleus 22302
                atom 22302
                  main group element atom 22183
                    main group molecular entity 22183
                      s-block molecular entity 21773
                        hydrogen molecular entity 21687
                          hydrides 20792
                            inorganic hydride 18727
                              pnictogen hydride 18708
                                nitrogen hydride 18583
                                  azane 18490
                                    ammonia 18489
                                      organic amino compound 18489
                                        polyamine 8965
                                          polyazaalkane 3906
                                            tetraethylenepentamine 15
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