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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:copper chelator
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Accession:CHEBI:166831 term browser browse the term
Definition:A chelator that is any compound containing a ligand (typically organic) which is able to form a bond to a central copper atom at two or more points.
Synonyms:related_synonym: copper chelate;   copper chelating agent;   copper chelating agents;   copper chelators
 xref: PMID:24934357;   PMID:29710396



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2,2,2-tetramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acaca acetyl-CoA carboxylase alpha multiple interactions EXP Trientine inhibits the reaction [Metformin results in increased phosphorylation of ACACA protein] CTD PMID:22492524 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in decreased expression of ACADM protein] CTD PMID:19634143 NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147
JBrowse link
G Acat1 acetyl-CoA acetyltransferase 1 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in decreased expression of ACAT1 protein] CTD PMID:19634143 NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855
JBrowse link
G Aco2 aconitase 2 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in decreased expression of ACO2 protein] CTD PMID:19634143 NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261
JBrowse link
G Actc1 actin, alpha, cardiac muscle 1 decreases expression EXP Trientine results in decreased expression of ACTC1 protein CTD PMID:21136691 NCBI chr 3:100,811,987...100,817,523
Ensembl chr 3:100,811,987...100,817,523
JBrowse link
G Actn4 actinin alpha 4 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of ACTN4 protein] CTD PMID:19634143 NCBI chr 1:84,182,783...84,251,867
Ensembl chr 1:84,182,788...84,251,847
JBrowse link
G Acy1 aminoacylase 1 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in decreased expression of ACY1 protein] CTD PMID:19634143 NCBI chr 8:107,072,354...107,077,756
Ensembl chr 8:107,072,358...107,077,682
JBrowse link
G Ager advanced glycosylation end product-specific receptor decreases expression
multiple interactions
ISO Trientine results in decreased expression of AGER protein
Trientine results in decreased expression of AGER mRNA; Trientine results in decreased expression of AGER protein
Tetradecanoylphorbol Acetate inhibits the reaction [Trientine inhibits the reaction [S100B protein results in increased expression of AGER protein]]; Trientine inhibits the reaction [S100B protein results in increased expression of AGER protein]
CTD PMID:23541064 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Agxt2 alanine-glyoxylate aminotransferase 2 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in decreased expression of AGXT2 protein] CTD PMID:19634143 NCBI chr 2:59,336,252...59,377,664
Ensembl chr 2:59,336,283...59,377,926
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of AIFM1 protein] CTD PMID:19634143 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256
JBrowse link
G Ak4 adenylate kinase 4 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in decreased expression of AK4 protein] CTD PMID:19634143 NCBI chr 5:116,039,222...116,099,064
Ensembl chr 5:116,039,616...116,098,618
JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of AKR1A1 protein] CTD PMID:19634143 NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674
JBrowse link
G Aldob aldolase, fructose-bisphosphate B multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of ALDOB protein] CTD PMID:19634143 NCBI chr 5:63,889,045...63,902,086
Ensembl chr 5:63,889,046...63,902,116
JBrowse link
G Anpep alanyl aminopeptidase, membrane multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in decreased expression of ANPEP protein] CTD PMID:19634143 NCBI chr 1:133,767,332...133,810,137
Ensembl chr 1:133,767,332...133,785,789
JBrowse link
G Anxa3 annexin A3 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of ANXA3 protein] CTD PMID:21136691 NCBI chr14:12,727,708...12,781,717
Ensembl chr14:12,719,795...12,781,617
JBrowse link
G Anxa5 annexin A5 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in decreased expression of ANXA5 protein]; Trientine inhibits the reaction [Streptozocin results in increased expression of ANXA5 protein] CTD PMID:19634143 PMID:21136691 NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369
JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of APOA1 protein] CTD PMID:19634143 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035
JBrowse link
G App amyloid beta precursor protein multiple interactions
decreases cleavage
decreases expression
increases metabolic processing
ISO Trientine inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of phosphatidylcholine hydroperoxide] which results in increased chemical synthesis of 4-hydroxy-2-nonenal]; Trientine inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of Phosphatidylcholines] which results in increased chemical synthesis of phosphatidylcholine hydroperoxide]; Trientine inhibits the reaction [APP protein results in increased activity of CASP3 protein]
Trientine results in decreased expression of and affects the localization of APP protein modified form
Trientine results in decreased cleavage of APP protein
Trientine results in decreased expression of APP protein modified form
Trientine results in increased metabolism of APP protein
CTD PMID:10940226 PMID:12963085 PMID:17964426 PMID:23541064 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Aqp1 aquaporin 1 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in decreased expression of AQP1 protein] CTD PMID:19634143 NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690
JBrowse link
G Ass1 argininosuccinate synthase 1 decreases expression EXP Trientine results in decreased expression of ASS1 protein CTD PMID:19634143 NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903
JBrowse link
G Atp5f1a ATP synthase F1 subunit alpha multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of ATP5F1A protein] CTD PMID:21136691 NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794
JBrowse link
G Atp5f1b ATP synthase F1 subunit beta multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of ATP5F1B protein] CTD PMID:21136691 NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273
JBrowse link
G Atp5mf ATP synthase membrane subunit f multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of ATP5MF protein] CTD PMID:19634143 NCBI chr12:9,421,665...9,428,236
Ensembl chr12:9,421,579...9,428,236
JBrowse link
G Atp5po ATP synthase peripheral stalk subunit OSCP multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of ATP5PO protein] CTD PMID:19634143 NCBI chr11:31,165,218...31,171,530
Ensembl chr11:31,165,217...31,171,592
JBrowse link
G Atp6v1a ATPase H+ transporting V1 subunit A decreases expression EXP Trientine results in decreased expression of ATP6V1A protein CTD PMID:19634143 NCBI chr11:56,561,444...56,614,694
Ensembl chr11:56,560,974...56,614,694
JBrowse link
G Atp6v1b2 ATPase H+ transporting V1 subunit B2 decreases expression EXP Trientine results in decreased expression of ATP6V1B2 protein CTD PMID:19634143 NCBI chr16:20,617,515...20,641,651
Ensembl chr16:20,617,518...20,641,745
JBrowse link
G Atp7a ATPase copper transporting alpha increases expression EXP Trientine results in increased expression of ATP7A mRNA; Trientine results in increased expression of ATP7A protein CTD PMID:24927960 NCBI chr  X:71,094,144...71,201,550
Ensembl chr  X:71,094,202...71,198,354
JBrowse link
G Bace1 beta-secretase 1 multiple interactions
decreases expression
ISO Tetradecanoylphorbol Acetate inhibits the reaction [Trientine inhibits the reaction [S100B protein results in increased expression of BACE1 protein]]; Trientine inhibits the reaction [S100B protein results in increased expression of BACE1 protein]
Trientine results in decreased expression of BACE1 protein
CTD PMID:23541064 NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
increases expression
multiple interactions
ISO Trientine results in decreased expression of BCL2 protein
Trientine results in increased expression of BCL2 protein
Copper Sulfate inhibits the reaction [Trientine results in increased expression of BCL2 protein]
CTD PMID:11369509 PMID:14513838 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Calm3 calmodulin 3 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in decreased expression of CALM3 protein] CTD PMID:19634143 NCBI chr 1:77,590,668...77,597,776
Ensembl chr 1:77,589,230...77,592,207
JBrowse link
G Calr calreticulin multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in decreased expression of CALR protein] CTD PMID:19634143 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO
EXP
Paraquat promotes the reaction [Trientine results in increased activity of CASP3 protein]; Trientine inhibits the reaction [APP protein results in increased activity of CASP3 protein] CTD PMID:11369509 PMID:12963085 PMID:14513838 PMID:22362149 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 increases activity ISO Trientine results in increased activity of CASP9 protein CTD PMID:14513838 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccs copper chaperone for superoxide dismutase multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in decreased expression of CCS mRNA]; Trientine inhibits the reaction [Streptozocin results in decreased expression of CCS protein] CTD PMID:24927960 NCBI chr 1:202,113,792...202,134,931
Ensembl chr 1:202,113,804...202,134,915
JBrowse link
G Cisd1 CDGSH iron sulfur domain 1 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of CISD1 protein] CTD PMID:19634143 NCBI chr20:17,255,302...17,268,688
Ensembl chr20:17,255,151...17,284,924
JBrowse link
G Clu clusterin multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of CLU protein] CTD PMID:19634143 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
JBrowse link
G Col6a1 collagen type VI alpha 1 chain multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of COL6A1 protein] CTD PMID:19634143 NCBI chr20:11,906,105...11,924,599
Ensembl chr20:11,905,957...11,924,597
JBrowse link
G Col6a2 collagen type VI alpha 2 chain multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of COL6A2 protein] CTD PMID:19634143 NCBI chr20:12,021,676...12,049,425
Ensembl chr20:12,021,767...12,057,564
JBrowse link
G Col6a3 collagen type VI alpha 3 chain multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of COL6A3 protein] CTD PMID:19634143 NCBI chr 9:91,361,578...91,439,434
Ensembl chr 9:91,361,583...91,439,471
JBrowse link
G Cp ceruloplasmin decreases expression ISO Trientine results in decreased expression of CP protein CTD PMID:24013775 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075
JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of CPT2 protein] CTD PMID:21136691 NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095
JBrowse link
G Cryz crystallin zeta multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in decreased expression of CRYZ protein] CTD PMID:19634143 NCBI chr 2:243,552,037...243,580,369
Ensembl chr 2:243,552,119...243,579,758
JBrowse link
G Cs citrate synthase increases expression EXP Trientine results in increased expression of CS protein CTD PMID:19634143 NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421
JBrowse link
G Cyc1 cytochrome c-1 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of CYC1 protein] CTD PMID:19634143 NCBI chr 7:108,067,106...108,069,483
Ensembl chr 7:108,067,115...108,069,479
JBrowse link
G Cyp4a2 cytochrome P450, family 4, subfamily a, polypeptide 2 multiple interactions EXP Trientine promotes the reaction [Streptozocin results in decreased expression of CYP4A2 protein] CTD PMID:19634143 NCBI chr 5:128,922,355...128,934,188
Ensembl chr 5:128,923,615...128,934,165
JBrowse link
G Dao D-amino-acid oxidase multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of DAO protein] CTD PMID:19634143 NCBI chr12:42,592,342...42,613,046
Ensembl chr12:42,592,343...42,612,741
JBrowse link
G Dlat dihydrolipoamide S-acetyltransferase multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of DLAT protein] CTD PMID:21136691 NCBI chr 8:50,979,151...51,004,435
Ensembl chr 8:50,978,051...51,004,479
JBrowse link
G Dld dihydrolipoamide dehydrogenase multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of DLD protein] CTD PMID:21136691 NCBI chr 6:47,904,153...47,924,814
Ensembl chr 6:47,903,914...47,924,795
JBrowse link
G Dlst dihydrolipoamide S-succinyltransferase multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of DLST protein] CTD PMID:19634143 PMID:21136691 NCBI chr 6:104,758,511...104,783,296
Ensembl chr 6:104,758,631...104,783,296
JBrowse link
G Eno1-ps1 enolase 1, (alpha), pseudogene 1 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in decreased expression of ENO1-PS1 protein] CTD PMID:19634143 NCBI chr 3:57,576,643...57,578,321
Ensembl chr 3:57,576,709...57,578,013
JBrowse link
G Ephx1 epoxide hydrolase 1 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of EPHX1 protein] CTD PMID:19634143 NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235
JBrowse link
G Etfa electron transfer flavoprotein subunit alpha multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in decreased expression of ETFA protein] CTD PMID:19634143 NCBI chr 8:55,835,115...55,891,890
Ensembl chr 8:55,835,134...55,891,969
JBrowse link
G Etfb electron transfer flavoprotein subunit beta multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in decreased expression of ETFB protein] CTD PMID:19634143 NCBI chr 1:93,851,908...93,866,072
Ensembl chr 1:93,851,858...93,866,068
JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of FN1 mRNA] CTD PMID:16973718 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Fxyd2 FXYD domain-containing ion transport regulator 2 increases expression EXP Trientine results in increased expression of FXYD2 protein CTD PMID:19634143 NCBI chr 8:45,712,887...45,720,032
Ensembl chr 8:45,712,903...45,720,203
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of G6PC1 protein] CTD PMID:19634143 NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
JBrowse link
G Gatm glycine amidinotransferase multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in decreased expression of GATM protein] CTD PMID:19634143 NCBI chr 3:109,658,919...109,675,508
Ensembl chr 3:109,658,951...109,684,129
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in decreased expression of GGT1 protein] CTD PMID:19634143 NCBI chr20:13,074,695...13,104,095
Ensembl chr20:13,074,700...13,108,442
JBrowse link
G Gng12 G protein subunit gamma 12 increases expression EXP Trientine results in increased expression of GNG12 protein CTD PMID:19634143 NCBI chr 4:96,011,118...96,134,767
Ensembl chr 4:96,010,952...96,134,712
JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of GOT2 protein] CTD PMID:19634143 NCBI chr19:9,174,304...9,199,995
Ensembl chr19:9,174,311...9,199,994
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of GPX1 protein] CTD PMID:19634143 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Gpx3 glutathione peroxidase 3 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of GPX3 protein] CTD PMID:19634143 NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in decreased expression of GSTA3 protein] CTD PMID:19634143 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of GSTA2 protein] CTD PMID:19634143 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases expression EXP Trientine results in decreased expression of GSTP1 protein CTD PMID:12883709 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Hao2 hydroxyacid oxidase 2 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in decreased expression of HAO2 protein] CTD PMID:19634143 NCBI chr 2:186,200,137...186,232,997
Ensembl chr 2:186,200,504...186,224,425
JBrowse link
G Hbb hemoglobin subunit beta multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in decreased expression of HBB-B1 protein] CTD PMID:19634143 NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Trientine inhibits the reaction [Dimethyldithiocarbamate results in increased expression of HMOX1 protein]; Trientine inhibits the reaction [Ziram results in increased expression of HMOX1 protein] CTD PMID:25714994 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hsd17b10 hydroxysteroid (17-beta) dehydrogenase 10 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in decreased expression of HSD17B10 protein] CTD PMID:21136691 NCBI chr  X:21,089,152...21,091,597
Ensembl chr  X:21,089,122...21,109,488
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in decreased expression of HSPA5 protein] CTD PMID:19634143 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in decreased expression of HSPA9 protein] CTD PMID:19634143 NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292
JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in decreased expression of HSPD1 protein]; Trientine inhibits the reaction [Streptozocin results in increased expression of HSPD1 protein] CTD PMID:19634143 PMID:21136691 NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in decreased expression of HSPE1 protein] CTD PMID:19634143 NCBI chr 9:56,589,912...56,593,000
Ensembl chr 9:56,589,789...56,593,089
JBrowse link
G Hspg2 heparan sulfate proteoglycan 2 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of HSPG2 protein] CTD PMID:19634143 NCBI chr 5:149,677,437...149,778,594
Ensembl chr 5:149,677,476...149,778,594
JBrowse link
G Ins2 insulin 2 multiple interactions ISO Trientine inhibits the reaction [[Copper co-treated with Ascorbic Acid] results in increased oxidation of and affects the folding of INS protein] CTD PMID:23403016 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Ldhb lactate dehydrogenase B multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of LDHB protein] CTD PMID:19634143 PMID:21136691 NCBI chr 4:175,428,382...175,446,403
Ensembl chr 4:175,428,385...175,446,403
JBrowse link
G Mdh1 malate dehydrogenase 1 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of MDH1 protein] CTD PMID:21136691 NCBI chr14:95,630,625...95,645,920
Ensembl chr14:95,630,306...95,645,925
JBrowse link
G Mdh2 malate dehydrogenase 2 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in decreased expression of MDH2 protein] CTD PMID:19634143 NCBI chr12:20,894,269...20,907,225
Ensembl chr12:20,894,262...20,907,271
JBrowse link
G Mme membrane metallo-endopeptidase multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in decreased expression of MME protein] CTD PMID:19634143 NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792
JBrowse link
G Ndufa10 NADH:ubiquinone oxidoreductase subunit A10 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of NDUFA10 protein] CTD PMID:21136691 NCBI chr 9:93,007,034...93,041,825
Ensembl chr 9:93,007,042...93,042,560
JBrowse link
G Ndufab1 NADH:ubiquinone oxidoreductase subunit AB1 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of NDUFAB1 protein] CTD PMID:19634143 NCBI chr 1:176,644,696...176,658,131
Ensembl chr 1:176,644,703...176,658,099
JBrowse link
G Ndufs2 NADH:ubiquinone oxidoreductase core subunit S2 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of NDUFS2 protein] CTD PMID:19634143 NCBI chr13:83,654,402...83,671,474
Ensembl chr13:83,654,406...83,671,420
JBrowse link
G Ndufs4 NADH:ubiquinone oxidoreductase subunit S4 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of NDUFS4 protein] CTD PMID:19634143 NCBI chr 2:45,951,327...46,061,829
Ensembl chr 2:45,951,313...46,061,846
JBrowse link
G Ndufv2 NADH:ubiquinone oxidoreductase core subunit V2 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of NDUFV2 protein] CTD PMID:19634143 NCBI chr 9:105,690,454...105,710,669
Ensembl chr 9:105,690,455...105,710,713
JBrowse link
G Nnt nicotinamide nucleotide transhydrogenase multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of NNT protein] CTD PMID:19634143 NCBI chr 2:51,411,413...51,505,125
Ensembl chr 2:51,411,413...51,504,823
JBrowse link
G Oat ornithine aminotransferase multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in decreased expression of OAT protein] CTD PMID:19634143 NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682
JBrowse link
G Ogdh oxoglutarate dehydrogenase multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of OGDH protein] CTD PMID:19634143 NCBI chr14:81,150,021...81,217,479
Ensembl chr14:81,150,091...81,217,479
JBrowse link
G Pc pyruvate carboxylase multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of PC protein] CTD PMID:19634143 NCBI chr 1:201,799,374...201,898,412
Ensembl chr 1:201,804,267...201,898,380
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of PCK1 protein] CTD PMID:19634143 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
JBrowse link
G Phb1 prohibitin 1 decreases expression EXP Trientine results in decreased expression of PHB1 protein CTD PMID:21136691 NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042
JBrowse link
G Podxl podocalyxin-like increases expression EXP Trientine results in increased expression of PODXL protein CTD PMID:19634143 NCBI chr 4:60,135,124...60,181,829
Ensembl chr 4:60,135,109...60,181,899
JBrowse link
G Ppia peptidylprolyl isomerase A multiple interactions ISO Trientine inhibits the reaction [Copper results in decreased secretion of PPIA protein] CTD PMID:19635393 NCBI chr14:81,279,292...81,282,960
Ensembl chr14:81,275,091...81,299,601
JBrowse link
G Prnp prion protein increases expression
affects response to substance
EXP Trientine results in increased expression of PRNP mRNA; Trientine results in increased expression of PRNP protein
PRNP protein affects the susceptibility to Trientine
CTD PMID:22362149 NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937
JBrowse link
G Pyroxd2 pyridine nucleotide-disulphide oxidoreductase domain 2 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of PYROXD2 protein] CTD PMID:19634143 NCBI chr 1:241,523,278...241,549,083
Ensembl chr 1:241,523,377...241,548,761
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Trientine results in decreased expression of and affects the localization of RELA protein CTD PMID:23541064 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rps6 ribosomal protein S6 multiple interactions
increases phosphorylation
EXP Trientine inhibits the reaction [Metformin results in decreased phosphorylation of RPS6 protein]
Trientine results in increased phosphorylation of RPS6 protein
CTD PMID:22492524 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602
JBrowse link
G S100b S100 calcium binding protein B multiple interactions ISO Tetradecanoylphorbol Acetate inhibits the reaction [Trientine inhibits the reaction [S100B protein results in increased expression of AGER protein]]; Tetradecanoylphorbol Acetate inhibits the reaction [Trientine inhibits the reaction [S100B protein results in increased expression of BACE1 protein]]; Trientine inhibits the reaction [S100B protein results in increased expression of AGER protein]; Trientine inhibits the reaction [S100B protein results in increased expression of BACE1 protein] CTD PMID:23541064 NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743
JBrowse link
G Sdha succinate dehydrogenase complex flavoprotein subunit A multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of SDHA protein] CTD PMID:19634143 PMID:21136691 NCBI chr 1:28,935,965...28,960,936
Ensembl chr 1:28,940,164...28,961,535
JBrowse link
G Sdhb succinate dehydrogenase complex iron sulfur subunit B multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of SDHB protein] CTD PMID:19634143 NCBI chr 5:153,264,906...153,285,570
Ensembl chr 5:153,264,899...153,314,293
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of SERPINE1 mRNA] CTD PMID:16973718 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Sfxn1 sideroflexin 1 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of SFXN1 protein] CTD PMID:19634143 NCBI chr17:10,486,250...10,522,640
Ensembl chr17:10,486,271...10,522,529
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in decreased expression of SLC22A6 protein] CTD PMID:19634143 NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
JBrowse link
G Slc25a10 solute carrier family 25 member 10 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of SLC25A10 protein] CTD PMID:19634143 NCBI chr10:105,765,598...105,775,159
Ensembl chr10:105,765,372...105,773,556
JBrowse link
G Slc25a3 solute carrier family 25 member 3 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of SLC25A3 protein] CTD PMID:19634143 NCBI chr 7:25,611,937...25,619,401
Ensembl chr 7:25,586,725...25,667,727
JBrowse link
G Slc25a5 solute carrier family 25 member 5 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of SLC25A5 protein] CTD PMID:19634143 NCBI chr  X:116,031,896...116,034,963
Ensembl chr  X:116,031,803...116,034,967
JBrowse link
G Slc31a1 solute carrier family 31 member 1 increases expression
multiple interactions
EXP
ISO
Trientine results in increased expression of SLC31A1 mRNA
Trientine results in increased expression of SLC31A1 mRNA; Trientine results in increased expression of SLC31A1 protein
[Trientine results in increased expression of SLC31A1 mRNA] which results in decreased susceptibility to oxaliplatin; [Trientine results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Carboplatin; [Trientine results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Cisplatin; Trientine promotes the reaction [SLC31A1 protein results in increased uptake of Platinum]
CTD PMID:22362149 PMID:22491798 PMID:22914438 NCBI chr 5:75,814,744...75,844,241
Ensembl chr 5:75,814,743...75,844,228
JBrowse link
G Slc31a2 solute carrier family 31 member 2 multiple interactions EXP Trientine promotes the reaction [Streptozocin results in increased expression of SLC31A2 mRNA]; Trientine promotes the reaction [Streptozocin results in increased expression of SLC31A2 protein] CTD PMID:24927960 NCBI chr 5:75,738,008...75,748,542
Ensembl chr 5:75,738,024...75,748,542
JBrowse link
G Slc3a1 solute carrier family 3 member 1 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in decreased expression of SLC3A1 protein] CTD PMID:19634143 NCBI chr 6:9,608,169...9,641,881
Ensembl chr 6:9,608,178...9,641,907
JBrowse link
G Smad4 SMAD family member 4 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of SMAD4 mRNA] CTD PMID:16973718 NCBI chr18:67,243,742...67,274,438
Ensembl chr18:67,243,742...67,274,438
JBrowse link
G Snap25 synaptosome associated protein 25 increases expression ISO Trientine results in increased expression of SNAP25 protein CTD PMID:23541064 NCBI chr 3:124,041,898...124,123,761
Ensembl chr 3:124,041,898...124,123,760
JBrowse link
G Sod1 superoxide dismutase 1 decreases expression
increases activity
decreases activity
multiple interactions
ISO
EXP
Trientine results in decreased expression of SOD1 protein
Trientine results in increased activity of SOD1 protein
Trientine results in decreased activity of SOD1 protein
Chlorpromazine inhibits the reaction [Copper inhibits the reaction [Trientine results in decreased activity of SOD1 protein]]; Copper inhibits the reaction [Trientine results in decreased activity of SOD1 protein]; Sucrose inhibits the reaction [Copper inhibits the reaction [Trientine results in decreased activity of SOD1 protein]]; Trientine inhibits the reaction [Streptozocin results in decreased expression of and results in decreased activity of SOD1 protein]; Trientine inhibits the reaction [Streptozocin results in decreased expression of SOD1 protein]
[Trientine results in decreased abundance of Copper] which results in decreased activity of SOD1 protein; Copper Sulfate inhibits the reaction [Trientine results in decreased activity of SOD1 protein]
CTD PMID:11369509 PMID:14513838 PMID:19634143 PMID:21140194 PMID:22362149 More... NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP
ISO
Trientine inhibits the reaction [Streptozocin results in decreased expression of SOD2 protein]
Trientine results in increased expression of and results in increased activity of SOD2 protein
CTD PMID:14513838 PMID:19634143 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sod3 superoxide dismutase 3 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in decreased expression of SOD3 mRNA]; Trientine inhibits the reaction [Streptozocin results in decreased expression of SOD3 protein] CTD PMID:16973718 NCBI chr14:58,610,104...58,615,845
Ensembl chr14:58,609,958...58,615,990
JBrowse link
G Syp synaptophysin increases expression ISO Trientine results in increased expression of SYP protein CTD PMID:23541064 NCBI chr  X:14,849,444...14,864,553
Ensembl chr  X:14,849,444...14,864,745
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of TGFB1 mRNA] CTD PMID:16973718 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tinag tubulointerstitial nephritis antigen multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of TINAG protein] CTD PMID:19634143 NCBI chr 8:77,800,031...77,885,077
Ensembl chr 8:77,800,032...77,885,077
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases phosphorylation
ISO Paraquat promotes the reaction [Trientine results in increased phosphorylation of TP53 protein]; Trientine results in increased expression of and results in increased activity of TP53 protein CTD PMID:11369509 PMID:14513838 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Ttr transthyretin multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in decreased expression of TTR protein] CTD PMID:19634143 NCBI chr18:11,941,791...11,951,008
Ensembl chr18:11,943,789...11,951,008
JBrowse link
G Uba1 ubiquitin-like modifier activating enzyme 1 multiple interactions ISO Trientine inhibits the reaction [Dimethyldithiocarbamate results in decreased activity of and results in decreased ubiquitination of UBA1 protein]; Trientine inhibits the reaction [Ziram results in decreased activity of and results in decreased ubiquitination of UBA1 protein] CTD PMID:25714994 NCBI chr  X:1,508,700...1,530,677
Ensembl chr  X:1,508,666...1,530,636
JBrowse link
G Uqcrc1 ubiquinol-cytochrome c reductase core protein 1 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of UQCRC1 protein] CTD PMID:19634143 PMID:21136691 NCBI chr 8:109,589,735...109,601,481
Ensembl chr 8:109,589,706...109,601,480
JBrowse link
G Vdac1 voltage-dependent anion channel 1 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of VDAC1 protein] CTD PMID:19634143 NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640
JBrowse link
G Vdac2 voltage-dependent anion channel 2 multiple interactions EXP Trientine inhibits the reaction [Streptozocin results in increased expression of VDAC2 protein] CTD PMID:19634143 NCBI chr15:2,462,877...2,476,802
Ensembl chr15:2,463,056...2,476,553
JBrowse link
5-chloro-7-iodoquinolin-8-ol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions ISO Clioquinol inhibits the reaction [[Copper co-treated with Cholesterol] results in increased activity of ACHE protein] CTD PMID:25856695 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Ago2 argonaute RISC catalytic component 2 multiple interactions ISO [Clioquinol co-treated with zinc chloride] results in decreased expression of AGO2 mRNA; [Clioquinol co-treated with zinc chloride] results in decreased expression of AGO2 protein CTD PMID:22415087 NCBI chr 7:105,018,202...105,105,120
Ensembl chr 7:105,029,120...105,104,974
JBrowse link
G Ak1 adenylate kinase 1 decreases expression ISO Clioquinol results in decreased expression of AK1 mRNA CTD PMID:19502547 NCBI chr 3:15,912,431...15,923,045
Ensembl chr 3:15,912,485...15,923,041
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol co-treated with Copper] results in increased phosphorylation of AKT1 protein]; [Clioquinol co-treated with Copper] results in increased phosphorylation of AKT1 protein CTD PMID:16648635 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol binds to Copper] which results in increased degradation of APP protein modified form]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol co-treated with Copper] results in decreased expression of APP protein alternative form]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [[Clioquinol binds to Copper] which results in increased degradation of APP protein modified form]; [Clioquinol binds to Copper] which results in increased degradation of APP protein modified form; [Clioquinol co-treated with Copper] results in decreased expression of APP protein alternative form; Clioquinol inhibits the reaction [Copper results in increased secretion of APP protein alternative form]; Clioquinol inhibits the reaction [Zinc results in increased secretion of APP protein alternative form]; pyrazolanthrone inhibits the reaction [[Clioquinol co-treated with Copper] results in decreased expression of APP protein alternative form] CTD PMID:16648635 PMID:18346929 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Ar androgen receptor multiple interactions ISO [Clioquinol binds to Copper] which results in decreased expression of AR protein CTD PMID:17308104 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO Clioquinol results in increased expression of ATF3 mRNA CTD PMID:32661532 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Atm ATM serine/threonine kinase increases phosphorylation ISO Clioquinol results in increased phosphorylation of ATM protein CTD PMID:22627294 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Atox1 antioxidant 1 copper chaperone increases oxidation ISO Clioquinol results in increased oxidation of ATOX1 protein CTD PMID:33034664 NCBI chr10:39,564,855...39,579,892
Ensembl chr10:39,564,857...39,579,950
JBrowse link
G Bnip3l BCL2 interacting protein 3 like decreases expression ISO Clioquinol results in decreased expression of BNIP3L mRNA CTD PMID:19502547 NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Clioquinol inhibits the reaction [Isoflurane results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:17287498 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Clioquinol results in increased expression of CDKN1A mRNA CTD PMID:22627294 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Commd1 copper metabolism domain containing 1 affects response to substance ISO COMMD1 gene SNP affects the susceptibility to Clioquinol CTD PMID:25622337 NCBI chr14:96,880,463...96,984,494
Ensembl chr14:96,880,463...96,984,501
JBrowse link
G Dbh dopamine beta-hydroxylase increases expression
decreases secretion
ISO Clioquinol results in increased expression of DBH mRNA
Clioquinol results in decreased secretion of DBH protein
CTD PMID:33034664 NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248
JBrowse link
G Dcp1b decapping mRNA 1B multiple interactions ISO [Clioquinol co-treated with zinc chloride] results in decreased expression of DCP1B mRNA CTD PMID:22415087 NCBI chr 4:152,358,267...152,395,747
Ensembl chr 4:152,358,241...152,397,145
JBrowse link
G Dicer1 dicer 1 ribonuclease III multiple interactions ISO [Clioquinol co-treated with zinc chloride] results in decreased expression of DICER1 protein CTD PMID:22415087 NCBI chr 6:123,627,529...123,692,278
Ensembl chr 6:123,631,250...123,693,965
JBrowse link
G Drosha drosha ribonuclease III multiple interactions ISO [Clioquinol co-treated with zinc chloride] affects the expression of DROSHA protein CTD PMID:22415087 NCBI chr 2:61,864,886...61,976,688
Ensembl chr 2:61,864,970...61,976,688
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [[Copper binds to Clioquinol] which results in increased phosphorylation of EGFR protein]; [4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline results in decreased phosphorylation of and results in decreased activity of EGFR protein] inhibits the reaction [[Copper binds to Clioquinol] which results in increased phosphorylation of MAPK1 protein]; [4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline results in decreased phosphorylation of and results in decreased activity of EGFR protein] inhibits the reaction [[Copper binds to Clioquinol] which results in increased phosphorylation of MAPK3 protein]; [[Clioquinol binds to Copper] which results in increased activity of SRC protein] which results in increased phosphorylation of and results in increased activity of EGFR protein; [Clioquinol binds to Copper] which results in increased phosphorylation of EGFR protein; [FN1 protein co-treated with [Clioquinol binds to Copper]] results in increased expression of EGFR protein; AG 1879 inhibits the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of and results in increased activity of EGFR protein]; FN1 protein promotes the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of EGFR protein]; ITGA2 protein promotes the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of EGFR protein]; ITGA5 protein promotes the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of EGFR protein] CTD PMID:18346929 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 decreases expression ISO Clioquinol results in decreased expression of EGLN1 mRNA CTD PMID:19502547 NCBI chr19:52,867,914...52,907,169
Ensembl chr19:52,869,486...52,907,777
JBrowse link
G Egln2 egl-9 family hypoxia-inducible factor 2 decreases expression ISO Clioquinol results in decreased expression of EGLN2 mRNA CTD PMID:19502547 NCBI chr 1:82,451,554...82,459,809
Ensembl chr 1:82,451,555...82,459,751
JBrowse link
G Egr1 early growth response 1 increases expression ISO Clioquinol results in increased expression of EGR1 mRNA CTD PMID:19502547 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E multiple interactions ISO [Clioquinol co-treated with zinc chloride] results in increased expression of EIF4E mRNA; [Clioquinol co-treated with zinc chloride] results in increased expression of EIF4E protein CTD PMID:22415087 NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683
JBrowse link
G Epo erythropoietin increases expression
decreases expression
ISO Clioquinol results in increased expression of EPO mRNA
Clioquinol results in decreased expression of EPO mRNA
CTD PMID:16973622 PMID:19502547 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO [FN1 protein co-treated with [Clioquinol binds to Copper]] results in increased expression of EGFR protein; FN1 protein promotes the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of EGFR protein] CTD PMID:18346929 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Clioquinol promotes the reaction [FOS protein binds to CXCL8 promoter] CTD PMID:29966605 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO Clioquinol results in increased expression of GADD45A mRNA CTD PMID:22627294 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gata2 GATA binding protein 2 decreases expression
multiple interactions
ISO Clioquinol results in decreased expression of GATA2 protein
GATA2 protein inhibits the reaction [Clioquinol results in increased expression of CXCL8 mRNA]; GATA2 protein inhibits the reaction [Clioquinol results in increased secretion of CXCL8 protein]
CTD PMID:29966605 NCBI chr 4:120,654,205...120,667,763
Ensembl chr 4:120,658,986...120,667,761
JBrowse link
G Gata3 GATA binding protein 3 decreases expression
multiple interactions
ISO Clioquinol results in decreased expression of GATA3 protein
Clioquinol inhibits the reaction [GATA3 protein binds to CXCL8 promoter]; GATA3 protein inhibits the reaction [Clioquinol results in increased expression of CXCL8 mRNA]; GATA3 protein inhibits the reaction [Clioquinol results in increased secretion of CXCL8 protein]
CTD PMID:29966605 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391
JBrowse link
G H2ax H2A.X variant histone increases phosphorylation ISO Clioquinol results in increased phosphorylation of H2AX protein CTD PMID:22627294 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases expression
decreases hydroxylation
decreases ubiquitination
increases activity
ISO [Zinc co-treated with Copper] inhibits the reaction [Clioquinol results in increased expression of HIF1A protein]; Clioquinol inhibits the reaction [HIF1AN protein results in increased hydroxylation of HIF1A protein]
[Clioquinol co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of HIF1A protein; HIF1A protein promotes the reaction [Clioquinol results in increased expression of VEGFA protein]
Clioquinol results in decreased hydroxylation of HIF1A protein
Clioquinol results in decreased ubiquitination of HIF1A protein
Clioquinol results in increased activity of HIF1A protein
CTD PMID:16973622 PMID:19502547 PMID:19679656 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hif1an hypoxia inducible factor 1 subunit alpha inhibitor multiple interactions
decreases activity
ISO Clioquinol inhibits the reaction [HIF1AN protein results in increased hydroxylation of HIF1A protein]
Clioquinol results in decreased activity of HIF1AN protein
CTD PMID:16973622 NCBI chr 1:243,419,175...243,440,464
Ensembl chr 1:243,419,194...243,434,327
JBrowse link
G Hif3a hypoxia inducible factor 3 subunit alpha decreases expression ISO Clioquinol results in decreased expression of HIF3A mRNA CTD PMID:19502547 NCBI chr 1:77,718,110...77,750,448
Ensembl chr 1:77,722,471...77,749,758
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Clioquinol results in increased expression of HMOX1 mRNA CTD PMID:32661532 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Itga2 integrin subunit alpha 2 multiple interactions ISO ITGA2 protein promotes the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of EGFR protein] CTD PMID:18346929 NCBI chr 2:46,520,345...46,621,487
Ensembl chr 2:46,523,948...46,621,481
JBrowse link
G Itga5 integrin subunit alpha 5 multiple interactions ISO ITGA5 protein promotes the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of EGFR protein] CTD PMID:18346929 NCBI chr 7:134,478,963...134,502,837
Ensembl chr 7:134,478,968...134,502,837
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Clioquinol promotes the reaction [JUN protein binds to CXCL8 promoter] CTD PMID:29966605 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Lox lysyl oxidase increases expression
decreases secretion
ISO Clioquinol results in increased expression of LOX mRNA
Clioquinol results in decreased secretion of LOX protein
CTD PMID:33034664 NCBI chr18:45,964,311...46,041,477
Ensembl chr18:45,967,343...46,041,477
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol co-treated with Copper] results in increased phosphorylation of MAPK1 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of MAPK1 protein]; [4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline results in decreased phosphorylation of and results in decreased activity of EGFR protein] inhibits the reaction [[Copper binds to Clioquinol] which results in increased phosphorylation of MAPK1 protein]; [Clioquinol binds to Copper] which results in increased phosphorylation of MAPK1 protein; [Clioquinol co-treated with Copper] results in increased phosphorylation of MAPK1 protein; [Clioquinol co-treated with Zinc] results in increased phosphorylation of MAPK1 protein; AG 1879 inhibits the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:16648635 PMID:18346929 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of MAPK3 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol co-treated with Copper] results in increased phosphorylation of MAPK3 protein]; 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of MAPK3 protein]; [4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline results in decreased phosphorylation of and results in decreased activity of EGFR protein] inhibits the reaction [[Copper binds to Clioquinol] which results in increased phosphorylation of MAPK3 protein]; [Clioquinol binds to Copper] which results in increased phosphorylation of MAPK3 protein; [Clioquinol co-treated with Copper] results in increased phosphorylation of MAPK3 protein; [Clioquinol co-treated with Zinc] results in increased phosphorylation of MAPK3 protein; AG 1879 inhibits the reaction [[Clioquinol binds to Copper] which results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:16648635 PMID:18346929 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO [Clioquinol co-treated with Copper] results in increased phosphorylation of MAPK8 protein; [Clioquinol co-treated with Zinc] results in increased phosphorylation of MAPK8 protein; pyrazolanthrone inhibits the reaction [[Clioquinol co-treated with Copper] results in increased phosphorylation of MAPK8 protein] CTD PMID:16648635 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mif macrophage migration inhibitory factor increases expression ISO Clioquinol results in increased expression of MIF mRNA CTD PMID:19502547 NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504
JBrowse link
G Mir130a microRNA 130a multiple interactions ISO [Clioquinol co-treated with zinc chloride] results in decreased expression of MIR130A mRNA CTD PMID:22415087 NCBI chr 3:69,822,542...69,822,629
Ensembl chr 3:69,822,542...69,822,629
JBrowse link
G Mir223 microRNA 223 multiple interactions ISO [Clioquinol co-treated with zinc chloride] results in decreased expression of MIR223 mRNA CTD PMID:22415087 NCBI chr  X:61,141,887...61,141,996
Ensembl chr  X:61,141,887...61,141,996
JBrowse link
G Mir29a microRNA 29a multiple interactions ISO [Clioquinol co-treated with zinc chloride] results in decreased expression of MIR29A mRNA CTD PMID:22415087 NCBI chr 4:59,650,608...59,650,695 JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO [Clioquinol co-treated with Copper] results in increased expression of and results in increased activity of MMP2 protein CTD PMID:16648635 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions ISO [Clioquinol co-treated with Copper] results in increased expression of and results in increased activity of MMP3 protein CTD PMID:16648635 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Clioquinol inhibits the reaction [MOG protein results in increased activity of MMP9 protein] CTD PMID:23360710 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mog myelin oligodendrocyte glycoprotein multiple interactions ISO Clioquinol inhibits the reaction [MOG protein results in increased activity of MMP9 protein] CTD PMID:23360710 NCBI chr20:1,513,137...1,523,473
Ensembl chr20:1,513,239...1,523,474
JBrowse link
G Ngf nerve growth factor multiple interactions ISO Clioquinol inhibits the reaction [NGF protein results in increased phosphorylation of NTRK1 protein]; trichostatin A inhibits the reaction [Clioquinol inhibits the reaction [NGF protein results in increased phosphorylation of NTRK1 protein]] CTD PMID:25758465 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Ntrk1 neurotrophic receptor tyrosine kinase 1 multiple interactions ISO Clioquinol inhibits the reaction [NGF protein results in increased phosphorylation of NTRK1 protein]; trichostatin A inhibits the reaction [Clioquinol inhibits the reaction [NGF protein results in increased phosphorylation of NTRK1 protein]] CTD PMID:25758465 NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770
JBrowse link
G P4ha2 prolyl 4-hydroxylase subunit alpha 2 decreases expression ISO Clioquinol results in decreased expression of P4HA2 mRNA CTD PMID:19502547 NCBI chr10:38,243,047...38,271,989
Ensembl chr10:38,243,139...38,287,314
JBrowse link
G Pgk1 phosphoglycerate kinase 1 increases expression ISO Clioquinol results in increased expression of PGK1 mRNA CTD PMID:19502547 NCBI chr  X:71,271,454...71,287,429
Ensembl chr  X:71,271,440...71,287,418
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO [[Clioquinol binds to Copper] which results in increased activity of SRC protein] which results in increased phosphorylation of and results in increased activity of EGFR protein; [Clioquinol binds to Copper] which results in increased phosphorylation of and results in increased activity of SRC protein CTD PMID:18346929 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases phosphorylation
ISO 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Clioquinol results in increased phosphorylation of TP53 protein] CTD PMID:22627294 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
decreases expression
multiple interactions
ISO Clioquinol results in increased expression of VEGFA mRNA; Clioquinol results in increased expression of VEGFA protein
Clioquinol results in decreased expression of VEGFA mRNA
HIF1A protein promotes the reaction [Clioquinol results in increased expression of VEGFA protein]
CTD PMID:16973622 PMID:19502547 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Vopp1 VOPP1 WW domain binding protein decreases expression ISO Clioquinol results in decreased expression of ECOP mRNA CTD PMID:19502547 NCBI chr 4:87,363,678...87,432,747
Ensembl chr 4:87,363,477...87,450,375
JBrowse link
D-penicillamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin I converting enzyme 2 increases expression ISO Penicillamine results in increased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Ahcy adenosylhomocysteinase increases activity
multiple interactions
ISO Penicillamine results in increased activity of AHCY protein
Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of AHCY protein]
CTD PMID:22945834 NCBI chr 3:143,569,134...143,584,359
Ensembl chr 3:143,569,094...143,584,393
JBrowse link
G Alox12 arachidonate 12-lipoxygenase, 12S type increases expression
decreases expression
EXP Penicillamine results in increased expression of ALOX12 mRNA
Penicillamine results in decreased expression of ALOX12 mRNA
CTD PMID:19575532 NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542
JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein increases expression EXP Penicillamine results in increased expression of ALOX5AP mRNA CTD PMID:19575532 NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986
JBrowse link
G Anxa1 annexin A1 decreases expression
increases expression
EXP Penicillamine results in decreased expression of ANXA1 mRNA
Penicillamine results in increased expression of ANXA1 mRNA
CTD PMID:19575532 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
JBrowse link
G Anxa4 annexin A4 increases expression
decreases expression
EXP Penicillamine results in increased expression of ANXA4 mRNA
Penicillamine results in decreased expression of ANXA4 mRNA
CTD PMID:19575532 NCBI chr 4:119,184,378...119,241,183
Ensembl chr 4:119,184,374...119,241,161
JBrowse link
G App amyloid beta precursor protein multiple interactions
increases metabolic processing
ISO Penicillamine inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of Phosphatidylcholines] which results in increased chemical synthesis of phosphatidylcholine hydroperoxide]; Penicillamine inhibits the reaction [APP protein results in increased activity of CASP3 protein]
Penicillamine results in increased metabolism of APP protein
CTD PMID:10940226 PMID:12963085 PMID:17964426 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Atf6 activating transcription factor 6 multiple interactions ISO Penicillamine results in increased metabolism of and results in increased activity of ATF6 protein CTD PMID:19722195 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
JBrowse link
G Atp7a ATPase copper transporting alpha multiple interactions ISO [Penicillamine co-treated with bathocuproine sulfonate] promotes the reaction [CLU protein binds to ATP7A protein] CTD PMID:21242307 NCBI chr  X:71,094,144...71,201,550
Ensembl chr  X:71,094,202...71,198,354
JBrowse link
G Atp7b ATPase copper transporting beta multiple interactions ISO [Penicillamine co-treated with ATP7B gene mutant form] results in decreased activity of CAT protein; [Penicillamine co-treated with bathocuproine sulfonate] promotes the reaction [CLU protein binds to ATP7B protein]; Penicillamine inhibits the reaction [ATP7B gene mutant form results in decreased abundance of Copper]; Penicillamine inhibits the reaction [ATP7B gene mutant form results in decreased abundance of Glutathione]; Penicillamine inhibits the reaction [ATP7B gene mutant form results in decreased expression of CP protein]
Penicillamine inhibits the reaction [ATP7B protein mutant form results in increased abundance of Copper]; Penicillamine inhibits the reaction [ATP7B protein mutant form results in increased expression of TNF mRNA]; Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of AHCY protein]; Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of CPT1A protein]; Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of DNMT3B mRNA]; Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of HSPA5 protein]; Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of PPARA mRNA]; Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of SREBF1 mRNA]
CTD PMID:21242307 PMID:22945834 PMID:24368744 NCBI chr16:69,952,286...70,024,404
Ensembl chr16:69,951,778...70,023,636
JBrowse link
G Bbc3 Bcl-2 binding component 3 decreases expression ISO Penicillamine results in decreased expression of BBC3 protein CTD PMID:22843330 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Penicillamine results in decreased expression of BCL2 mRNA; Penicillamine results in decreased expression of BCL2 protein CTD PMID:22843330 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions EXP andrographolide promotes the reaction [Penicillamine inhibits the reaction [Copper Sulfate results in decreased expression of and results in increased cleavage of BID protein]]; Penicillamine inhibits the reaction [Copper Sulfate results in decreased expression of and results in increased cleavage of BID protein]; Penicillamine promotes the reaction [andrographolide inhibits the reaction [Copper Sulfate results in decreased expression of and results in increased cleavage of BID protein]] CTD PMID:20946909 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G C1s complement C1s multiple interactions ISO Penicillamine inhibits the reaction [C4A protein binds to C1S protein]; Penicillamine inhibits the reaction [C4B protein binds to C1S protein] CTD PMID:8435078 NCBI chr 4:157,430,249...157,442,438
Ensembl chr 4:157,430,117...157,442,303
JBrowse link
G C3 complement C3 increases expression EXP Penicillamine results in increased expression of C3 mRNA CTD PMID:19575532 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
JBrowse link
G C4a complement C4A multiple interactions ISO Penicillamine inhibits the reaction [C4A protein binds to C1S protein] CTD PMID:8435078 NCBI chr20:4,005,731...4,020,083
Ensembl chr20:4,005,731...4,020,080
JBrowse link
G C4b complement C4B (Chido blood group) multiple interactions ISO Penicillamine inhibits the reaction [C4B protein binds to C1S protein] CTD PMID:8435078 NCBI chr20:4,197,371...4,211,684
Ensembl chr20:4,197,366...4,211,681
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
EXP
ISO
andrographolide promotes the reaction [Penicillamine inhibits the reaction [Copper Sulfate results in increased cleavage of CASP3 protein]]; Penicillamine inhibits the reaction [Copper Sulfate results in increased cleavage of CASP3 protein]; Penicillamine promotes the reaction [andrographolide inhibits the reaction [Copper Sulfate results in increased cleavage of CASP3 protein]]
Penicillamine results in increased cleavage of CASP3 protein
Penicillamine inhibits the reaction [APP protein results in increased activity of CASP3 protein]
CTD PMID:12963085 PMID:19722195 PMID:20946909 PMID:22843330 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp9 caspase 9 multiple interactions EXP andrographolide promotes the reaction [Penicillamine inhibits the reaction [Copper Sulfate results in increased activity of CASP9 protein]]; Penicillamine inhibits the reaction [Copper Sulfate results in increased activity of CASP9 protein]; Penicillamine promotes the reaction [andrographolide inhibits the reaction [Copper Sulfate results in increased activity of CASP9 protein]] CTD PMID:20946909 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase decreases expression
multiple interactions
ISO Penicillamine results in decreased expression of CAT mRNA
[Penicillamine co-treated with ATP7B gene mutant form] results in decreased activity of CAT protein
CTD PMID:22843330 PMID:24368744 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO Penicillamine results in increased expression of CCL3 mRNA CTD PMID:22843330 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 increases expression ISO
EXP
Penicillamine results in increased expression of CCL4 mRNA CTD PMID:19575532 PMID:22843330 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 increases expression EXP Penicillamine results in increased expression of CCL5 mRNA CTD PMID:19575532 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccr5 C-C motif chemokine receptor 5 increases expression
decreases expression
EXP Penicillamine results in increased expression of CCR5 mRNA
Penicillamine results in decreased expression of CCR5 mRNA
CTD PMID:19575532 NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260
JBrowse link
G Cd14 CD14 molecule decreases expression
increases expression
EXP Penicillamine results in decreased expression of CD14 mRNA
Penicillamine results in increased expression of CD14 mRNA
CTD PMID:19575532 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
JBrowse link
G Cd163 CD163 molecule decreases expression
increases expression
EXP Penicillamine results in decreased expression of CD163 mRNA
Penicillamine results in increased expression of CD163 mRNA
CTD PMID:19575532 NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878
JBrowse link
G Cd38 CD38 molecule increases expression EXP Penicillamine results in increased expression of CD38 mRNA CTD PMID:19575532 NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986
JBrowse link
G Cd52 CD52 molecule decreases expression EXP Penicillamine results in decreased expression of CD52 mRNA CTD PMID:19575532 NCBI chr 5:146,319,789...146,321,348
Ensembl chr 5:146,319,969...146,321,348
JBrowse link
G Clu clusterin multiple interactions ISO [Penicillamine co-treated with bathocuproine sulfonate] promotes the reaction [CLU protein binds to ATP7A protein]; [Penicillamine co-treated with bathocuproine sulfonate] promotes the reaction [CLU protein binds to ATP7B protein] CTD PMID:21242307 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
JBrowse link
G Cp ceruloplasmin decreases expression
multiple interactions
ISO Penicillamine results in decreased expression of CP protein
Penicillamine inhibits the reaction [ATP7B gene mutant form results in decreased expression of CP protein]
CTD PMID:24013775 PMID:24368744 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression
multiple interactions
EXP
ISO
Penicillamine results in decreased expression of CPT1A mRNA
Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of CPT1A protein]
CTD PMID:19575532 PMID:22945834 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
JBrowse link
G Crp C-reactive protein decreases expression ISO Penicillamine results in decreased expression of CRP protein CTD PMID:241598 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Csf2 colony stimulating factor 2 increases expression EXP Penicillamine results in increased expression of CSF2 mRNA CTD PMID:19575532 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 increases expression
decreases expression
EXP Penicillamine results in increased expression of CXCR4 mRNA
Penicillamine results in decreased expression of CXCR4 mRNA
CTD PMID:19575532 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO Penicillamine results in increased expression of CYP1A1 mRNA CTD PMID:22843330 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression ISO Penicillamine results in increased expression of CYP2E1 mRNA CTD PMID:22843330 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Penicillamine results in increased expression of DDIT3 mRNA; Penicillamine results in increased expression of DDIT3 protein CTD PMID:19722195 PMID:22843330 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha decreases expression ISO Penicillamine results in decreased expression of DNMT3A mRNA CTD PMID:22945834 NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687
JBrowse link
G Dnmt3b DNA methyltransferase 3 beta multiple interactions ISO Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of DNMT3B mRNA] CTD PMID:22945834 NCBI chr 3:142,130,592...142,169,124
Ensembl chr 3:142,130,592...142,169,124
JBrowse link
G Dusp1 dual specificity phosphatase 1 decreases expression EXP Penicillamine results in decreased expression of DUSP1 mRNA CTD PMID:19575532 NCBI chr10:16,680,489...16,683,276 JBrowse link
G Dusp6 dual specificity phosphatase 6 increases expression EXP Penicillamine results in increased expression of DUSP6 mRNA CTD PMID:19575532 NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185
JBrowse link
G Egr1 early growth response 1 increases expression EXP
ISO
Penicillamine results in increased expression of EGR1 mRNA CTD PMID:19575532 PMID:22843330 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO Penicillamine results in increased phosphorylation of and results in increased activity of EIF2AK3 protein CTD PMID:22843330 NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation ISO Penicillamine results in increased phosphorylation of EIF2S1 protein CTD PMID:22843330 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Eln elastin affects localization ISO Penicillamine affects the localization of ELN protein CTD PMID:3954958 NCBI chr12:21,968,544...22,011,929
Ensembl chr12:21,968,544...22,011,928
JBrowse link
G Fcnb ficolin B increases expression EXP Penicillamine results in increased expression of FCNB mRNA CTD PMID:19575532 NCBI chr 3:11,393,771...11,402,198
Ensembl chr 3:11,393,739...11,402,151
JBrowse link
G Fmo1 flavin containing dimethylaniline monoxygenase 1 increases expression ISO Penicillamine results in increased expression of FMO1 mRNA CTD PMID:22843330 NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647
JBrowse link
G Fmo5 flavin containing dimethylaniline monoxygenase 5 increases expression ISO Penicillamine results in increased expression of FMO5 mRNA CTD PMID:22843330 NCBI chr 2:185,197,184...185,249,699
Ensembl chr 2:185,222,204...185,249,693
JBrowse link
G Fn1 fibronectin 1 increases expression EXP Penicillamine results in increased expression of FN1 mRNA CTD PMID:19575532 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO Penicillamine results in increased expression of GADD45A mRNA CTD PMID:22843330 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gatm glycine amidinotransferase increases expression EXP Penicillamine results in increased expression of GATM mRNA CTD PMID:19575532 NCBI chr 3:109,658,919...109,675,508
Ensembl chr 3:109,658,951...109,684,129
JBrowse link
G Gstm5 glutathione S-transferase, mu 5 increases expression ISO Penicillamine results in increased expression of GSTM3 mRNA CTD PMID:22843330 NCBI chr 2:195,531,627...195,534,562
Ensembl chr 2:195,531,495...195,534,553
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
decreases expression
ISO [Penicillamine co-treated with bathocuproine sulfonate] results in increased expression of HMOX1 protein
Penicillamine results in increased expression of HMOX1 mRNA
Penicillamine analog results in decreased expression of HMOX1 protein
CTD PMID:19323979 PMID:21242307 PMID:22843330 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hp haptoglobin decreases expression ISO Penicillamine results in decreased expression of HP protein CTD PMID:241598 NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO Penicillamine results in increased expression of HSPA1A mRNA; Penicillamine results in increased expression of HSPA1A protein CTD PMID:22843330
G Hspa1l heat shock protein family A (Hsp70) member 1 like increases expression ISO Penicillamine results in increased expression of HSPA1L mRNA CTD PMID:22843330 NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571
JBrowse link
G Hspa2 heat shock protein family A (Hsp70) member 2 increases expression ISO Penicillamine results in increased expression of HSPA2 mRNA CTD PMID:22843330 NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions
ISO Penicillamine results in increased expression of HSPA5 protein
Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of HSPA5 protein]
CTD PMID:19722195 PMID:22843330 PMID:22945834 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Ifng interferon gamma increases expression EXP Penicillamine results in increased expression of IFNG mRNA CTD PMID:19575532 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO Penicillamine inhibits the reaction [IGF1 protein results in increased activity of MTR protein] CTD PMID:14745455 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Il10 interleukin 10 increases expression EXP Penicillamine results in increased expression of IL10 mRNA CTD PMID:19575532 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il13 interleukin 13 decreases expression
increases expression
EXP Penicillamine results in decreased expression of IL13 mRNA
Penicillamine results in increased expression of IL13 mRNA
CTD PMID:19575532 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il15 interleukin 15 increases expression EXP Penicillamine results in increased expression of IL15 mRNA CTD PMID:19575532 NCBI chr19:25,640,013...25,706,818
Ensembl chr19:25,640,251...25,706,820
JBrowse link
G Il1b interleukin 1 beta increases expression EXP Penicillamine results in increased expression of IL1B mRNA CTD PMID:19575532 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il21 interleukin 21 increases expression EXP Penicillamine results in increased expression of IL21 mRNA CTD PMID:21227906 NCBI chr 2:120,119,598...120,126,941
Ensembl chr 2:120,119,444...120,126,996
JBrowse link
G Il23a interleukin 23 subunit alpha increases expression ISO Penicillamine results in increased expression of IL23A protein CTD PMID:19575532 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
JBrowse link
G Il3ra interleukin 3 receptor subunit alpha increases expression EXP Penicillamine results in increased expression of IL3RA mRNA CTD PMID:19575532 NCBI chr12:16,318,081...16,323,781
Ensembl chr12:16,318,081...16,323,484
JBrowse link
G Il4 interleukin 4 increases expression EXP Penicillamine results in increased expression of IL4 mRNA CTD PMID:9182889 PMID:21227906 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 increases expression EXP
ISO
Penicillamine results in increased expression of IL6 protein CTD PMID:19575532 PMID:21227906 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Klf4 Kruppel like factor 4 increases expression EXP Penicillamine results in increased expression of KLF4 mRNA CTD PMID:19575532 NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602
JBrowse link
G Lgals1 galectin 1 increases expression EXP Penicillamine results in increased expression of LGALS1 mRNA CTD PMID:19575532 NCBI chr 7:110,485,239...110,488,345
Ensembl chr 7:110,481,392...110,488,345
JBrowse link
G LOC686035 similar to heat shock 70kDa protein 6 (HSP70B) increases expression ISO Penicillamine results in increased expression of HSPA6 mRNA CTD PMID:22843330 NCBI chr13:83,271,340...83,275,267 JBrowse link
G Loxl2 lysyl oxidase-like 2 decreases activity ISO Penicillamine results in decreased activity of LOXL2 protein CTD PMID:16023247 NCBI chr15:44,683,449...44,773,067
Ensembl chr15:44,683,880...44,773,067
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions
decreases expression
ISO PMAIP1 mutant form inhibits the reaction [Penicillamine results in decreased expression of MCL1 protein] CTD PMID:22843330 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Mpo myeloperoxidase decreases secretion
multiple interactions
ISO Penicillamine results in decreased secretion of MPO protein
Penicillamine promotes the reaction [[MPO protein results in increased oxidation of dibromoacetonitrile] which results in increased chemical synthesis of Cyanides]; Penicillamine promotes the reaction [MPO protein results in increased oxidation of dibromoacetonitrile]
CTD PMID:6324512 PMID:25614581 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase multiple interactions ISO Penicillamine inhibits the reaction [IGF1 protein results in increased activity of MTR protein] CTD PMID:14745455 NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases expression EXP Penicillamine results in increased expression of NFE2L2 mRNA CTD PMID:19575532 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression ISO Penicillamine results in increased expression of NOS2 mRNA CTD PMID:22843330 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 increases expression EXP Penicillamine results in increased expression of NR4A1 mRNA CTD PMID:19575532 NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Penicillamine results in increased cleavage of PARP1 protein CTD PMID:22843330 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression
multiple interactions
ISO Penicillamine results in increased expression of PMAIP1 mRNA; Penicillamine results in increased expression of PMAIP1 protein
PMAIP1 mutant form inhibits the reaction [Penicillamine results in decreased expression of MCL1 protein]
CTD PMID:22843330 NCBI chr18:59,986,187...59,990,174
Ensembl chr18:59,986,017...59,992,429
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of PPARA mRNA] CTD PMID:22945834 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Prl prolactin multiple interactions
increases expression
ISO Danazol inhibits the reaction [Penicillamine results in increased expression of PRL] CTD PMID:4087275 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Ptger2 prostaglandin E receptor 2 increases expression EXP Penicillamine results in increased expression of PTGER2 mRNA CTD PMID:19575532 NCBI chr15:18,215,013...18,228,714
Ensembl chr15:18,217,285...18,228,714
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 increases expression ISO Penicillamine results in increased expression of PTGS1 mRNA CTD PMID:22843330 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
G RT1-A1 RT1 class Ia, locus A1 affects response to substance ISO HLA-B gene polymorphism affects the susceptibility to Penicillamine CTD PMID:3437418 PMID:3459889 PMID:3487119 NCBI chr20:4,905,309...4,914,593 JBrowse link
G RT1-Db1 RT1 class II, locus Db1 increases response to substance ISO HLA-DRB1 gene polymorphism results in increased susceptibility to Penicillamine CTD PMID:6420562 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
JBrowse link
G S100a4 S100 calcium-binding protein A4 increases expression EXP Penicillamine results in increased expression of S100A4 mRNA CTD PMID:19575532 NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254
JBrowse link
G S100a6 S100 calcium binding protein A6 increases expression EXP Penicillamine results in increased expression of S100A6 mRNA CTD PMID:19575532 NCBI chr 2:176,100,619...176,102,181
Ensembl chr 2:176,100,899...176,102,180
JBrowse link
G S100a8 S100 calcium binding protein A8 decreases expression
increases expression
EXP Penicillamine results in decreased expression of S100A8 mRNA
Penicillamine results in increased expression of S100A8 mRNA
CTD PMID:19575532 NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
JBrowse link
G S100a9 S100 calcium binding protein A9 decreases expression
increases expression
EXP Penicillamine results in decreased expression of S100A9 mRNA
Penicillamine results in increased expression of S100A9 mRNA
CTD PMID:19575532 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
JBrowse link
G Selenbp1 selenium binding protein 1 decreases expression EXP Penicillamine results in decreased expression of SELENBP1 mRNA CTD PMID:19575532 Ensembl chr 2:182,493,978...182,504,594 JBrowse link
G Slc11a1 solute carrier family 11 member 1 increases expression EXP Penicillamine results in increased expression of SLC11A1 mRNA CTD PMID:19575532 NCBI chr 9:75,957,193...75,968,115
Ensembl chr 9:75,957,316...75,968,101
JBrowse link
G Slc28a2 solute carrier family 28 member 2 decreases expression
increases expression
EXP Penicillamine results in decreased expression of SLC28A2 mRNA
Penicillamine results in increased expression of SLC28A2 mRNA
CTD PMID:19575532 NCBI chr 3:109,324,815...109,387,702
Ensembl chr 3:109,366,996...109,387,702
JBrowse link
G Slc30a1 solute carrier family 30 member 1 decreases expression
increases expression
EXP Penicillamine results in decreased expression of SLC30A1 mRNA
Penicillamine results in increased expression of SLC30A1 mRNA
CTD PMID:19575532 NCBI chr13:103,491,037...103,494,910
Ensembl chr13:103,491,037...103,494,910
JBrowse link
G Slc31a1 solute carrier family 31 member 1 multiple interactions
increases expression
ISO [Penicillamine results in increased expression of SLC31A1 mRNA] which results in decreased susceptibility to Oxaliplatin; [Penicillamine results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Carboplatin; [Penicillamine results in increased expression of SLC31A1 mRNA] which results in increased susceptibility to Cisplatin; Cisplatin promotes the reaction [Penicillamine results in increased expression of SLC31A1 mRNA]; Penicillamine promotes the reaction [Cisplatin results in increased expression of SLC31A1 mRNA] CTD PMID:22914438 NCBI chr 5:75,814,744...75,844,241
Ensembl chr 5:75,814,743...75,844,228
JBrowse link
G Slc4a1 solute carrier family 4 member 1 (Diego blood group) decreases expression EXP Penicillamine results in decreased expression of SLC4A1 mRNA CTD PMID:19575532 NCBI chr10:87,306,865...87,323,132
Ensembl chr10:87,306,872...87,323,117
JBrowse link
G Sod1 superoxide dismutase 1 decreases activity ISO Penicillamine analog results in decreased activity of SOD1 protein CTD PMID:19323979 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sp1 Sp1 transcription factor increases expression ISO Penicillamine results in increased expression of SP1 mRNA CTD PMID:22914438 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO Penicillamine promotes the reaction [ATP7B protein mutant form results in decreased expression of SREBF1 mRNA] CTD PMID:22945834 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Stx3 syntaxin 3 increases expression
decreases expression
EXP Penicillamine results in increased expression of STX3 mRNA
Penicillamine results in decreased expression of STX3 mRNA
CTD PMID:19575532 NCBI chr 1:208,617,018...208,686,240
Ensembl chr 1:208,639,115...208,685,805
JBrowse link
G Tfrc transferrin receptor increases expression EXP Penicillamine results in increased expression of TFRC mRNA CTD PMID:19575532 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
ISO Penicillamine results in increased expression of TNF protein
Penicillamine inhibits the reaction [ATP7B protein mutant form results in increased expression of TNF mRNA]
CTD PMID:19575532 PMID:22945834 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 increases expression
decreases expression
ISO Penicillamine results in increased expression of TP53 protein
Penicillamine results in decreased expression of TP53 mRNA
CTD PMID:22843330 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Xbp1 X-box binding protein 1 increases splicing ISO Penicillamine results in increased splicing of XBP1 mRNA CTD PMID:19722195 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
JBrowse link
diethyldithiocarbamic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase multiple interactions
decreases activity
EXP Ditiocarb inhibits the reaction [Ditiocarb analog results in decreased activity of ALAD protein]; Ditiocarb inhibits the reaction [lead acetate results in decreased activity of ALAD protein] CTD PMID:2177232 NCBI chr 5:75,961,993...75,972,334
Ensembl chr 5:75,961,993...75,972,474
JBrowse link
G Aldh3a1 aldehyde dehydrogenase 3 family, member A1 increases chemical synthesis ISO ALDH3A1 protein results in increased chemical synthesis of Ditiocarb CTD PMID:18591790 NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681
JBrowse link
G Anxa1 annexin A1 increases expression EXP Ditiocarb results in increased expression of ANXA1 mRNA CTD PMID:16603213 NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions ISO [[Ditiocarb binds to Copper] which affects the localization of CYCS protein] promotes the reaction [[[CYCS protein binds to APAF1 protein binds to CASP9 protein] which results in increased metabolism of and results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein] CTD PMID:22951949 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP mRNA]; Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP protein] CTD PMID:28242320 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Bace1 beta-secretase 1 multiple interactions ISO Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of BACE1 mRNA] CTD PMID:28242320 NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876
JBrowse link
G Casp1 caspase 1 multiple interactions
affects expression
ISO [Ditiocarb co-treated with Zinc] results in decreased expression of CASP1 protein
Ditiocarb affects the expression of CASP1 protein
CTD PMID:25929180 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
[[Ditiocarb binds to Copper] which affects the localization of CYCS protein] promotes the reaction [[[CYCS protein binds to APAF1 protein binds to CASP9 protein] which results in increased metabolism of and results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein]
[Ditiocarb co-treated with Arsenic Trioxide] results in increased activity of CASP3 protein
CTD PMID:22951949 PMID:27592447 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [Ditiocarb binds to Copper] which results in increased activity of CASP8 protein CTD PMID:22951949 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions ISO [[Ditiocarb binds to Copper] which affects the localization of CYCS protein] promotes the reaction [[[CYCS protein binds to APAF1 protein binds to CASP9 protein] which results in increased metabolism of and results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein] CTD PMID:22951949 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase decreases expression ISO Ditiocarb results in decreased expression of CAT mRNA CTD PMID:8279580 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccs copper chaperone for superoxide dismutase decreases expression EXP Ditiocarb results in decreased expression of CCS protein CTD PMID:20452388 NCBI chr 1:202,113,792...202,134,931
Ensembl chr 1:202,113,804...202,134,915
JBrowse link
G Cnp 2',3'-cyclic nucleotide 3' phosphodiesterase increases expression EXP Ditiocarb results in increased expression of CNP protein CTD PMID:22874009 NCBI chr10:85,511,164...85,517,723
Ensembl chr10:85,511,160...85,517,720
JBrowse link
G Cp ceruloplasmin multiple interactions ISO Ditiocarb inhibits the reaction [Pyruvaldehyde promotes the reaction [CP protein binds to CP protein]] CTD PMID:16756764 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO [[Ditiocarb binds to Copper] which affects the localization of CYCS protein] promotes the reaction [[[CYCS protein binds to APAF1 protein binds to CASP9 protein] which results in increased metabolism of and results in increased activity of CASP9 protein] which results in increased activity of CASP3 protein]; [Ditiocarb binds to Copper] which affects the localization of CYCS protein CTD PMID:22951949 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions EXP
ISO
Ditiocarb inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein] CTD PMID:18493746 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP Ditiocarb results in increased expression of CYP2B1 mRNA CTD PMID:8390837 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP Ditiocarb results in increased expression of CYP2B2 mRNA CTD PMID:8390837 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO Ditiocarb results in decreased activity of CYP2C19 protein CTD PMID:8819299 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity
multiple interactions
EXP
ISO
Ditiocarb results in decreased activity of CYP2E1 protein
Ditiocarb inhibits the reaction [CYP2E1 protein results in increased glutathionylation of Lamotrigine]; Ditiocarb inhibits the reaction [CYP2E1 protein results in increased metabolism of 2-xylene]; Ditiocarb inhibits the reaction [CYP2E1 protein results in increased metabolism of 3-xylene]; Ditiocarb inhibits the reaction [CYP2E1 protein results in increased metabolism of 4-xylene]; Ditiocarb inhibits the reaction [CYP2E1 protein results in increased metabolism of Theobromine]; Ditiocarb inhibits the reaction [CYP2E1 protein results in increased metabolism of Toluene]; Ditiocarb inhibits the reaction [CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]]
[Ditiocarb co-treated with CYP2E1 gene mutant form] results in decreased metabolism of Styrene; [Ditiocarb results in decreased activity of CYP2E1 protein] which results in decreased oxidation of Benzene
Ditiocarb inhibits the reaction [[Benzene results in increased expression of CYP2E1 protein] which results in increased metabolism of Benzene]; Ditiocarb inhibits the reaction [CYP2E1 protein results in increased hydroxylation of 4-nitrophenol]; Ditiocarb inhibits the reaction [CYP2E1 protein results in increased metabolism of methylformamide]; Ditiocarb inhibits the reaction [pyridine results in increased activity of CYP2E1 protein]
CTD PMID:1356728 PMID:1538706 PMID:1664256 PMID:8558417 PMID:8560479 More... NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression EXP Ditiocarb results in increased expression of DDIT4 protein CTD PMID:24764117 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
JBrowse link
G Dpysl2 dihydropyrimidinase-like 2 increases expression EXP Ditiocarb results in increased expression of DPYSL2 protein CTD PMID:22874009 NCBI chr15:41,005,551...41,111,724
Ensembl chr15:41,005,551...41,111,829
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions EXP Ditiocarb binds to and results in decreased activity of GSTA3 protein CTD PMID:6095330 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions EXP Ditiocarb binds to and results in decreased activity of GSTM1 protein CTD PMID:6095330 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression EXP Ditiocarb results in increased expression of GSTP1 protein CTD PMID:22874009 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Hadha hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha decreases expression EXP Ditiocarb results in decreased expression of HADHA protein CTD PMID:22874009 NCBI chr 6:26,187,969...26,227,605
Ensembl chr 6:26,187,956...26,227,869
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP Ditiocarb results in increased expression of HMOX1 protein CTD PMID:19467251 PMID:20452388 PMID:22874009 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 decreases activity ISO Ditiocarb results in decreased activity of HSD11B2 protein CTD PMID:22796344 NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO [[Paraquat co-treated with Ditiocarb] results in decreased activity of SOD1 protein] which results in increased expression of ICAM1 protein CTD PMID:10644010 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifng interferon gamma increases expression
multiple interactions
ISO Ditiocarb results in increased expression of IFNG protein
Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP mRNA]; Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of APP protein]; Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of BACE1 mRNA]; Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PSEN1 mRNA]; Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PSEN2 mRNA]; Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of Nitric Oxide]
Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased metabolism of Nitric Oxide]; Polysaccharides inhibits the reaction [Ditiocarb results in increased expression of IFNG protein]
CTD PMID:11498278 PMID:26826268 PMID:28242320 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
ISO Polysaccharides inhibits the reaction [Ditiocarb results in increased expression of IL1B protein] CTD PMID:26826268 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
EXP Ditiocarb results in increased phosphorylation of MAPK1 protein
Acetylcysteine inhibits the reaction [Ditiocarb results in increased phosphorylation of MAPK1 protein]; Nitric Oxide affects the reaction [Ditiocarb results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Ditiocarb results in increased phosphorylation of MAPK1 protein]
CTD PMID:16603213 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions
EXP Ditiocarb results in increased phosphorylation of MAPK3 protein
Acetylcysteine inhibits the reaction [Ditiocarb results in increased phosphorylation of MAPK3 protein]; Nitric Oxide affects the reaction [Ditiocarb results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Ditiocarb results in increased phosphorylation of MAPK3 protein]
CTD PMID:16603213 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mbp myelin basic protein increases expression EXP Ditiocarb results in increased expression of MBP protein CTD PMID:22874009 NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP Ditiocarb inhibits the reaction [Isoflurane affects the localization of NFKB1 protein] CTD PMID:18708911 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 affects expression
multiple interactions
ISO Ditiocarb affects the expression of NLRP3 protein
[Ditiocarb co-treated with Zinc] results in decreased expression of NLRP3 protein
CTD PMID:25929180 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP
ISO
Ditiocarb inhibits the reaction [Isoflurane results in increased expression of NOS2 protein]
Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]
CTD PMID:18708911 PMID:28242320 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Pla2g4a phospholipase A2 group IVA multiple interactions
increases expression
EXP Acetylcysteine inhibits the reaction [Ditiocarb results in increased expression of PLA2G4A mRNA]; Nitric Oxide affects the reaction [Ditiocarb results in increased expression of PLA2G4A mRNA]; Nitric Oxide affects the reaction [Ditiocarb results in increased expression of PLA2G4A protein]; U 0126 inhibits the reaction [Ditiocarb results in increased expression of PLA2G4A mRNA]; U 0126 inhibits the reaction [Ditiocarb results in increased expression of PLA2G4A protein]
Ditiocarb results in increased expression of PLA2G4A mRNA; Ditiocarb results in increased expression of PLA2G4A protein
CTD PMID:16603213 NCBI chr13:61,877,818...62,022,261
Ensembl chr13:61,877,813...62,022,266
JBrowse link
G Pln phospholamban multiple interactions
increases phosphorylation
EXP 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [Ditiocarb results in increased phosphorylation of PLN protein] CTD PMID:16288776 NCBI chr20:32,629,537...32,639,559 JBrowse link
G Prdx2 peroxiredoxin 2 increases expression EXP Ditiocarb results in increased expression of PRDX2 protein CTD PMID:22874009 NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194
JBrowse link
G Prdx6 peroxiredoxin 6 increases expression EXP Ditiocarb results in increased expression of PRDX6 protein CTD PMID:22874009 NCBI chr13:73,528,746...73,539,295
Ensembl chr13:73,528,210...73,539,355
JBrowse link
G Prnp prion protein increases expression EXP Ditiocarb results in increased expression of PRNP protein CTD PMID:20452388 NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937
JBrowse link
G Psen1 presenilin 1 multiple interactions ISO Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PSEN1 mRNA] CTD PMID:28242320 NCBI chr 6:103,323,014...103,375,088
Ensembl chr 6:103,323,120...103,371,650
JBrowse link
G Psen2 presenilin 2 multiple interactions ISO Ditiocarb inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PSEN2 mRNA] CTD PMID:28242320 NCBI chr13:91,967,506...91,993,240
Ensembl chr13:91,967,983...91,993,174
JBrowse link
G Pygb glycogen phosphorylase B increases expression EXP Ditiocarb results in increased expression of PYGB protein CTD PMID:22874009 NCBI chr 3:139,611,724...139,658,521
Ensembl chr 3:139,611,749...139,663,553
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Ditiocarb inhibits the reaction [Isoflurane affects the localization of RELA protein] CTD PMID:18708911 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Slc6a3 solute carrier family 6 member 3 increases expression EXP Ditiocarb results in increased expression of SLC6A3 protein CTD PMID:22874009 NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413
JBrowse link
G Snca synuclein alpha increases expression EXP Ditiocarb results in increased expression of SNCA protein CTD PMID:22874009 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
increases expression
decreases activity
ISO
EXP
[[Paraquat co-treated with Ditiocarb] results in decreased activity of SOD1 protein] which results in increased expression of ICAM1 protein
Ditiocarb results in increased expression of SOD1 protein
Ditiocarb results in increased expression of SOD1 mRNA
Ditiocarb inhibits the reaction [lactacystin affects the localization of SOD1 protein mutant form]
Ditiocarb results in decreased activity of SOD1 protein; Ditiocarb results in decreased activity of SOD1 protein mutant form
CTD PMID:8279580 PMID:10644010 PMID:15034941 PMID:16681429 PMID:19467251 More... NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP Ditiocarb results in decreased expression of and results in increased phosphorylation of TH protein CTD PMID:22874009 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Ditiocarb inhibits the reaction [Asbestos, Crocidolite results in increased secretion of TNF protein] CTD PMID:10486238 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions
ISO Ditiocarb results in increased expression of TP53 protein
Ditiocarb inhibits the reaction [cobaltous chloride results in increased expression of and results in increased activity of TP53 protein]; Ditiocarb inhibits the reaction [Oxygen deficiency results in increased expression of TP53 protein]
CTD PMID:10951577 PMID:11964141 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Uba1 ubiquitin-like modifier activating enzyme 1 multiple interactions ISO
EXP
Ditiocarb results in decreased activity of and results in decreased ubiquitination of UBA1 protein
Ditiocarb binds to and results in decreased activity of UBA1 protein
CTD PMID:22874009 PMID:25714994 NCBI chr  X:1,508,700...1,530,677
Ensembl chr  X:1,508,666...1,530,636
JBrowse link
G Ucp2 uncoupling protein 2 increases expression ISO Ditiocarb results in increased expression of UCP2 protein CTD PMID:18082129 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611
JBrowse link
ethylenediaminetetraacetic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme multiple interactions
decreases activity
ISO Zinc Sulfate inhibits the reaction [Edetic Acid results in decreased activity of ACE protein] CTD PMID:28544013 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
JBrowse link
G Ache acetylcholinesterase multiple interactions ISO Edetic Acid results in decreased metabolism of and results in decreased secretion of ACHE protein CTD PMID:23047022 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions EXP Edetic Acid inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]] CTD PMID:1322109 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Anpep alanyl aminopeptidase, membrane multiple interactions ISO Edetic Acid promotes the reaction [1,10-phenanthroline results in decreased activity of ANPEP protein] CTD PMID:17109655 NCBI chr 1:133,767,332...133,810,137
Ensembl chr 1:133,767,332...133,785,789
JBrowse link
G Aplp1 amyloid beta precursor like protein 1 multiple interactions ISO Edetic Acid inhibits the reaction [Zinc affects the localization of APLP1 protein] CTD PMID:24855651 NCBI chr 1:85,696,880...85,707,215
Ensembl chr 1:85,696,882...85,707,155
JBrowse link
G Aplp2 amyloid beta precursor like protein 2 multiple interactions ISO Edetic Acid inhibits the reaction [Zinc affects the localization of APLP2 protein] CTD PMID:24855651 NCBI chr 8:29,599,230...29,662,311
Ensembl chr 8:29,599,230...29,661,855
JBrowse link
G App amyloid beta precursor protein multiple interactions ISO Edetic Acid inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of phosphatidylcholine hydroperoxide] which results in increased chemical synthesis of 4-hydroxy-2-nonenal]; Edetic Acid inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of Phosphatidylcholines] which results in increased chemical synthesis of phosphatidylcholine hydroperoxide] CTD PMID:17964426 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Aspa aspartoacylase decreases activity ISO Edetic Acid results in decreased activity of ASPA protein CTD PMID:17027983 NCBI chr10:57,891,704...57,945,267
Ensembl chr10:57,892,104...57,945,272
JBrowse link
G Atp2a1 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 multiple interactions EXP [ferrous sulfate co-treated with Edetic Acid] results in decreased activity of ATP2A1 protein; Butylated Hydroxytoluene inhibits the reaction [[ferrous sulfate co-treated with Edetic Acid] results in decreased activity of ATP2A1 protein]; dicarbine inhibits the reaction [[ferrous sulfate co-treated with Edetic Acid] results in decreased activity of ATP2A1 protein] CTD PMID:12870653 NCBI chr 1:181,026,606...181,044,859
Ensembl chr 1:181,026,608...181,044,838
JBrowse link
G Bmp4 bone morphogenetic protein 4 multiple interactions ISO [Edetic Acid inhibits the reaction [Calcium binds to MGP protein]] inhibits the reaction [MGP protein binds to BMP4 protein] CTD PMID:18369157 NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
JBrowse link
G Casp1 caspase 1 multiple interactions ISO Edetic Acid inhibits the reaction [Ziram results in decreased expression of and results in increased degradation of CASP1 protein] CTD PMID:25929180 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Cat catalase multiple interactions ISO CAT inhibits the reaction [[XDH protein co-treated with Edetic Acid analog] results in increased oxidation of Uroporphyrinogens] CTD PMID:1567206 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cp ceruloplasmin multiple interactions ISO Edetic Acid inhibits the reaction [CP protein results in increased oxidation of 3-carboxy-2,2,5,5-tetramethylpyrrolidin-1-yloxyl] CTD PMID:22824865 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP Edetic Acid inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 enhancer]] CTD PMID:1322109 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO Edetic Acid inhibits the reaction [Cycloheximide results in increased degradation of CYP2E1 protein] CTD PMID:9143349 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Dld dihydrolipoamide dehydrogenase multiple interactions ISO Edetic Acid inhibits the reaction [Cadmium Chloride results in decreased activity of and results in increased phosphorylation of DLD protein] CTD PMID:29158198 NCBI chr 6:47,904,153...47,924,814
Ensembl chr 6:47,903,914...47,924,795
JBrowse link
G Dspp dentin sialophosphoprotein affects localization EXP Edetic Acid affects the localization of DSPP protein CTD PMID:23525114 NCBI chr14:5,565,562...5,571,669
Ensembl chr14:5,565,629...5,571,672
JBrowse link
G Dusp23 dual specificity phosphatase 23 multiple interactions ISO Edetic Acid inhibits the reaction [DUSP23 protein results in decreased phosphorylation of nitrophenylphosphate] CTD PMID:15147733 NCBI chr13:85,098,792...85,099,984
Ensembl chr13:85,097,899...85,100,093
JBrowse link
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 multiple interactions ISO Edetic Acid inhibits the reaction [Zinc results in decreased activity of ENPP7 protein] CTD PMID:12885774 NCBI chr10:104,242,223...104,246,589
Ensembl chr10:104,242,223...104,246,589
JBrowse link
G Esr1 estrogen receptor 1 increases expression ISO Edetic Acid results in increased expression of ESR1 mRNA CTD PMID:22083529 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Gh1 growth hormone 1 multiple interactions EXP Edetic Acid promotes the reaction [Triiodothyronine results in increased expression of GH1 mRNA] CTD PMID:10720163 NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078
JBrowse link
G Igfbp5 insulin-like growth factor binding protein 5 decreases degradation EXP Edetic Acid results in decreased degradation of IGFBP5 protein CTD PMID:8894652 NCBI chr 9:74,452,371...74,464,953
Ensembl chr 9:74,448,382...74,465,156
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Edetic Acid inhibits the reaction [Calcium promotes the reaction [Histamine results in increased expression of IL6 protein]] CTD PMID:11238657 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Itgam integrin subunit alpha M increases expression ISO Edetic Acid results in increased expression of ITGAM protein CTD PMID:8595612 NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO Edetic Acid promotes the reaction [dexamethasone 21-methanesulfonate binds to KEAP1 protein] CTD PMID:15865434 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Mbp myelin basic protein affects expression EXP Edetic Acid affects the expression of MBP mRNA CTD PMID:22954530 NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404
JBrowse link
G Mgp matrix Gla protein multiple interactions ISO [Edetic Acid inhibits the reaction [Calcium binds to MGP protein]] inhibits the reaction [MGP protein binds to BMP4 protein]; Edetic Acid inhibits the reaction [Calcium binds to MGP protein] CTD PMID:18369157 NCBI chr 4:169,766,290...169,769,612
Ensembl chr 4:169,766,279...169,769,667
JBrowse link
G Mmp8 matrix metallopeptidase 8 decreases activity ISO Edetic Acid results in decreased activity of MMP8 protein CTD PMID:15057751 NCBI chr 8:4,724,009...4,732,956
Ensembl chr 8:4,724,029...4,733,520
JBrowse link
G Mt1 metallothionein 1 multiple interactions ISO Edetic Acid inhibits the reaction [2-tert-butylhydroquinone results in increased expression of MT1 mRNA]; Edetic Acid inhibits the reaction [zinc chloride promotes the reaction [2-tert-butylhydroquinone results in increased expression of MT1 mRNA]] CTD PMID:14998373 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
JBrowse link
G Mt3 metallothionein 3 increases alkylation
affects metabolic processing
ISO Edetic Acid results in increased alkylation of MT3 protein
MT3 protein polymorphism affects the metabolism of Edetic Acid
CTD PMID:12383939 PMID:14983064 NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158
JBrowse link
G Neil1 nei-like DNA glycosylase 1 multiple interactions ISO [tris(2-carboxyethyl)phosphine co-treated with Edetic Acid] inhibits the reaction [Copper results in decreased activity of NEIL1 protein]; Edetic Acid inhibits the reaction [Iron binds to and results in decreased activity of NEIL1 protein] CTD PMID:20622253 NCBI chr 8:57,550,142...57,556,884
Ensembl chr 8:57,550,147...57,556,258
JBrowse link
G Optc opticin multiple interactions ISO Edetic Acid inhibits the reaction [Oxygen deficiency results in increased degradation of OPTC protein]; Edetic Acid inhibits the reaction [VEGFA protein results in increased degradation of OPTC protein] CTD PMID:22534113 NCBI chr13:45,353,954...45,368,254
Ensembl chr13:45,355,148...45,365,237
JBrowse link
G Pgp phosphoglycolate phosphatase decreases activity ISO Edetic Acid results in decreased activity of PGP protein CTD PMID:24338473 NCBI chr10:13,495,232...13,497,858
Ensembl chr10:13,494,291...13,497,858
JBrowse link
G Plat plasminogen activator, tissue type multiple interactions ISO Edetic Acid inhibits the reaction [Zinc results in increased expression of PLAT mRNA]; Edetic Acid inhibits the reaction [Zinc results in increased expression of PLAT protein]; Edetic Acid inhibits the reaction [Zinc results in increased secretion of PLAT protein] CTD PMID:21615740 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
JBrowse link
G Plg plasminogen multiple interactions ISO Edetic Acid inhibits the reaction [Zinc results in increased expression of PLG mRNA]; Edetic Acid inhibits the reaction [Zinc results in increased expression of PLG protein] CTD PMID:21615740 NCBI chr 1:48,325,186...48,367,643
Ensembl chr 1:48,325,185...48,367,786
JBrowse link
G Prl prolactin multiple interactions ISO Edetic Acid inhibits the reaction [PRL protein binds to PRLR protein] CTD PMID:6197504 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Prlr prolactin receptor multiple interactions ISO Edetic Acid inhibits the reaction [PRL protein binds to PRLR protein] CTD PMID:6197504 NCBI chr 2:59,134,147...59,324,719
Ensembl chr 2:59,134,588...59,324,718
JBrowse link
G Prnp prion protein multiple interactions ISO Edetic Acid inhibits the reaction [[Hydrogen Peroxide co-treated with Copper] results in increased cleavage of PRNP protein]; Edetic Acid inhibits the reaction [[Hydrogen Peroxide co-treated with Iron] results in increased cleavage of PRNP protein] CTD PMID:16595185 NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937
JBrowse link
G S100a2 S100 calcium binding protein A2 multiple interactions ISO Edetic Acid inhibits the reaction [Copper promotes the reaction [S100A2 protein binds to S100A2 protein]]; Edetic Acid inhibits the reaction [S100A2 protein binds to S100A2 protein] CTD PMID:21924240 NCBI chr 2:176,075,060...176,078,782 JBrowse link
G S100a4 S100 calcium-binding protein A4 multiple interactions ISO Edetic Acid inhibits the reaction [Copper promotes the reaction [S100A4 protein binds to S100A4 protein]] CTD PMID:21924240 NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254
JBrowse link
G Sell selectin L decreases expression ISO Edetic Acid results in decreased expression of SELL protein CTD PMID:8595612 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456
JBrowse link
G Slc30a10 solute carrier family 30, member 10 increases expression
multiple interactions
ISO Edetic Acid results in increased expression of SLC30A10 mRNA; Edetic Acid results in increased expression of SLC30A10 protein
Edetic Acid inhibits the reaction [SLC30A10 gene mutant form results in increased abundance of Manganese]
CTD PMID:22341971 PMID:22926781 NCBI chr13:96,998,143...97,048,076
Ensembl chr13:96,998,143...97,009,103
JBrowse link
G Sptan1 spectrin, alpha, non-erythrocytic 1 multiple interactions EXP Edetic Acid inhibits the reaction [Calcium results in increased cleavage of SPTAN1 protein] CTD PMID:17069801 NCBI chr 3:13,241,164...13,306,047
Ensembl chr 3:13,241,217...13,306,046
JBrowse link
G Srr serine racemase multiple interactions ISO Adenosine Triphosphate inhibits the reaction [Edetic Acid inhibits the reaction [SRR protein results in increased abundance of D-Aspartic Acid]]; Edetic Acid inhibits the reaction [SRR protein results in increased abundance of D-Aspartic Acid] CTD PMID:27387750 NCBI chr10:59,769,563...59,786,688
Ensembl chr10:59,769,571...59,787,011
JBrowse link
G Tnf tumor necrosis factor increases expression ISO Edetic Acid results in increased expression of TNF protein CTD PMID:29953848 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Edetic Acid inhibits the reaction [[Cadmium Chloride results in decreased activity of TP53 protein] inhibits the reaction [TP53 protein binds to TP53 gene]]; Edetic Acid inhibits the reaction [[Cadmium Chloride results in decreased activity of TP63 protein] inhibits the reaction [TP63 protein binds to TP53 gene]]; Edetic Acid inhibits the reaction [[Cadmium Chloride results in decreased activity of TP73 protein] inhibits the reaction [TP73 protein binds to TP53 gene]] CTD PMID:25446071 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tp63 tumor protein p63 multiple interactions ISO Edetic Acid inhibits the reaction [[Cadmium Chloride results in decreased activity of TP63 protein] inhibits the reaction [TP63 protein binds to TP53 gene]] CTD PMID:25446071 NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398
JBrowse link
G Tp73 tumor protein p73 multiple interactions ISO Edetic Acid inhibits the reaction [[Cadmium Chloride results in decreased activity of TP73 protein] inhibits the reaction [TP73 protein binds to TP53 gene]] CTD PMID:25446071 NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions ISO Edetic Acid inhibits the reaction [Capsaicin promotes the reaction [TRPV1 protein results in increased uptake of Calcium]] CTD PMID:17442041 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link
G Txnrd1 thioredoxin reductase 1 increases activity
multiple interactions
ISO Edetic Acid results in increased activity of TXNRD1 protein
Zinc inhibits the reaction [Edetic Acid results in increased activity of TXNRD1 protein]
CTD PMID:16774913 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
G Txnrd3 thioredoxin reductase 3 increases activity
multiple interactions
ISO Edetic Acid results in increased activity of TXNRD3 protein
Zinc inhibits the reaction [Edetic Acid results in increased activity of TXNRD3 protein]
CTD PMID:16774913 NCBI chr 4:122,072,548...122,112,493
Ensembl chr 4:122,072,548...122,112,491
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Edetic Acid inhibits the reaction [VEGFA protein results in increased degradation of OPTC protein] CTD PMID:22534113 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Xdh xanthine dehydrogenase multiple interactions ISO [XDH protein co-treated with Edetic Acid analog] results in increased oxidation of Uroporphyrinogens; CAT inhibits the reaction [[XDH protein co-treated with Edetic Acid analog] results in increased oxidation of Uroporphyrinogens] CTD PMID:1567206 NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
JBrowse link
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aars1 alanyl-tRNA synthetase 1 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of AARS1 mRNA CTD PMID:19013360 NCBI chr19:38,999,130...39,021,152
Ensembl chr19:38,999,163...39,021,147
JBrowse link
G Abcc10 ATP binding cassette subfamily C member 10 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of ABCC10 mRNA CTD PMID:12756304 NCBI chr 9:14,657,242...14,677,178
Ensembl chr 9:14,657,264...14,677,178
JBrowse link
G Abcc9 ATP binding cassette subfamily C member 9 increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of ABCC9 mRNA CTD PMID:12756304 NCBI chr 4:175,531,854...175,655,849
Ensembl chr 4:175,532,547...175,655,356
JBrowse link
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of ABL1 mRNA CTD PMID:12756304 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065
JBrowse link
G Acadl acyl-CoA dehydrogenase, long chain decreases expression
multiple interactions
ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of ACADL protein
Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of ACADL protein]
CTD PMID:19637192 NCBI chr 9:68,333,981...68,372,149
Ensembl chr 9:68,333,980...68,372,220
JBrowse link
G Agt angiotensinogen multiple interactions EXP N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [AGT protein results in decreased expression of CAT protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [AGT protein results in increased abundance of Reactive Oxygen Species]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [AGT protein results in increased localization of Zinc] CTD PMID:22427991 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [[Zinc Sulfate co-treated with prolinedithiocarbamate] affects the localization of AIFM1 protein] CTD PMID:18951928 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256
JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO [zinc chloride deficiency co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in decreased expression of ALPL mRNA CTD PMID:19913120 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
JBrowse link
G Ap2b1 adaptor related protein complex 2 subunit beta 1 increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of AP2B1 mRNA CTD PMID:12756304 NCBI chr10:68,099,397...68,205,023
Ensembl chr10:68,099,547...68,205,013
JBrowse link
G Apc2 APC regulator of WNT signaling pathway 2 increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of APC2 mRNA CTD PMID:12756304 NCBI chr 7:9,392,336...9,414,364
Ensembl chr 7:9,392,336...9,414,310
JBrowse link
G Apob apolipoprotein B decreases expression
multiple interactions
ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of APOB protein
Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of APOB protein]
CTD PMID:19637192 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
JBrowse link
G Arhgef18 Rho/Rac guanine nucleotide exchange factor 18 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of ARHGEF18 mRNA CTD PMID:12756304 NCBI chr12:1,395,035...1,503,081
Ensembl chr12:1,395,088...1,503,081
JBrowse link
G Atm ATM serine/threonine kinase increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of ATM mRNA CTD PMID:33645215 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Azin1 antizyme inhibitor 1 increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of AZIN1 mRNA CTD PMID:12756304 NCBI chr 7:69,654,773...69,681,578
Ensembl chr 7:69,654,663...69,681,578
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in increased expression of BAX protein]]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in increased expression of BAX protein]]] CTD PMID:19887557 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bbc3 Bcl-2 binding component 3 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of BBC3 mRNA CTD PMID:12756304 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
JBrowse link
G Bbs9 Bardet-Biedl syndrome 9 increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of BBS9 mRNA CTD PMID:12756304 NCBI chr 8:21,013,865...21,437,934
Ensembl chr 8:21,013,944...21,437,930
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in decreased expression of BCL2 protein]]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in decreased expression of BCL2 protein]]]
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of BCL2 mRNA
CTD PMID:19887557 PMID:33645215 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in decreased expression of BCL2L1 protein]]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in decreased expression of BCL2L1 protein]]] CTD PMID:19887557 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression
multiple interactions
ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of BGLAP protein
[zinc chloride co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased expression of BGLAP mRNA; [zinc chloride deficiency co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in decreased expression of BGLAP mRNA
CTD PMID:19913120 PMID:22228435 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
JBrowse link
G Brca2 BRCA2, DNA repair associated increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of BRCA2 mRNA CTD PMID:33645215 NCBI chr12:59,492...103,789
Ensembl chr12:59,819...100,567
JBrowse link
G Brd1 bromodomain containing 1 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of BRD1 mRNA CTD PMID:12756304 NCBI chr 7:119,774,187...119,822,031
Ensembl chr 7:119,774,188...119,822,031
JBrowse link
G Brd3 bromodomain containing 3 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of BRD3 mRNA CTD PMID:12756304 NCBI chr 3:10,773,163...10,829,675
Ensembl chr 3:10,775,272...10,829,577
JBrowse link
G Brd8 bromodomain containing 8 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of BRD8 mRNA CTD PMID:12756304 NCBI chr18:26,181,744...26,230,035
Ensembl chr18:26,181,732...26,229,884
JBrowse link
G Cacna1h calcium voltage-gated channel subunit alpha1 H multiple interactions ISO 3-cyanoalanine inhibits the reaction [[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Cyclophosphamide] results in increased expression of CACNA1H protein]; [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Cyclophosphamide] results in increased expression of CACNA1H protein CTD PMID:29129814 NCBI chr10:14,390,104...14,448,204
Ensembl chr10:14,390,113...14,448,376
JBrowse link
G Camsap1 calmodulin regulated spectrin-associated protein 1 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of CAMSAP1 mRNA CTD PMID:12756304 NCBI chr 3:8,746,176...8,806,072
Ensembl chr 3:8,746,176...8,806,072
JBrowse link
G Casp1 caspase 1 increases expression
multiple interactions
ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of CASP1 mRNA
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased activity of CASP1 protein]
CTD PMID:17622302 PMID:19130485 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity
decreases expression
ISO [IFNG protein co-treated with TNF protein co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased activity of CASP3 protein; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine affects the reaction [chromium hexavalent ion results in increased activity of CASP3 protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in increased cleavage of CASP3 protein]]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in increased cleavage of CASP3 protein]]]
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of CASP3 protein
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of CASP3 protein
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of CASP3 mRNA
CTD PMID:15966574 PMID:16844947 PMID:17169355 PMID:17979179 PMID:18778698 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases activity ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of CASP8 protein CTD PMID:17979179 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of CASP9 protein CTD PMID:17169355 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions
increases expression
EXP N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [AGT protein results in decreased expression of CAT protein]
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of CAT protein
CTD PMID:22427991 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of CCL2 mRNA CTD PMID:19013360 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl22 C-C motif chemokine ligand 22 increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of CCL22 mRNA CTD PMID:19013360 NCBI chr19:10,257,602...10,264,373
Ensembl chr19:10,257,601...10,264,400
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of CCL3 mRNA CTD PMID:19013360 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccnd1 cyclin D1 increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of CCND1 mRNA CTD PMID:12756304 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccr1 C-C motif chemokine receptor 1 increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of CCR1 mRNA CTD PMID:19013360 NCBI chr 8:123,556,286...123,561,841 JBrowse link
G Ccr2 C-C motif chemokine receptor 2 decreases expression
increases expression
ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of CCR2 mRNA
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of CCR2 mRNA
CTD PMID:12756304 PMID:19013360 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
JBrowse link
G Cd14 CD14 molecule multiple interactions
increases expression
ISO [Zinc co-treated with pyrithione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Calcitriol results in increased expression of CD14 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Calcitriol results in increased expression of CD14 protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD14 protein]; parthenolide promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Calcitriol results in increased expression of CD14 protein]]; pyrithione promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Calcitriol results in increased expression of CD14 protein]]
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of CD14 protein
CTD PMID:20089671 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
JBrowse link
G Cd86 CD86 molecule increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of CD86 protein CTD PMID:16892068 NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO [IFNG protein co-treated with TNF protein co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased cleavage of CDH1 protein; Zinc inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased cleavage of CDH1 protein] CTD PMID:16844947 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of CDKN1A mRNA CTD PMID:33645215 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cebpd CCAAT/enhancer binding protein delta decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of CEBPD mRNA CTD PMID:12756304 NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829
JBrowse link
G Cfp complement factor properdin increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of CFP mRNA CTD PMID:19013360 NCBI chr  X:1,162,014...1,167,576
Ensembl chr  X:1,161,979...1,167,573
JBrowse link
G Clcn7 chloride voltage-gated channel 7 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of CLCN7 mRNA CTD PMID:12756304 NCBI chr10:14,151,758...14,177,130
Ensembl chr10:14,151,758...14,177,130
JBrowse link
G Clcnkb chloride voltage-gated channel Kb increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of CLCNKB mRNA CTD PMID:12756304 NCBI chr 5:153,710,086...153,733,162
Ensembl chr 5:153,710,094...153,732,153
JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO [zinc chloride deficiency co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in decreased expression of COL1A1 mRNA CTD PMID:19913120 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Crebbp CREB binding protein multiple interactions ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [HIF1A protein binds to CREBBP protein] CTD PMID:16579968 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
JBrowse link
G Cryz crystallin zeta decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of CRYZ mRNA CTD PMID:12888634 NCBI chr 2:243,552,037...243,580,369
Ensembl chr 2:243,552,119...243,579,758
JBrowse link
G Ctdp1 CTD phosphatase subunit 1 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of CTDP1 mRNA CTD PMID:12756304 NCBI chr18:73,854,277...73,916,232
Ensembl chr18:73,854,282...73,916,457
JBrowse link
G Ctdsp2 CTD small phosphatase 2 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of CTDSP2 mRNA CTD PMID:12756304 NCBI chr 7:62,805,400...62,825,306
Ensembl chr 7:62,805,658...62,825,302
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO [IFNG protein co-treated with TNF protein co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased cleavage of CTNNB1 protein; Zinc inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased cleavage of CTNNB1 protein] CTD PMID:16844947 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Ctsd cathepsin D multiple interactions EXP N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Ethambutol results in increased expression of and affects the localization of CTSD protein] CTD PMID:19063910 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
JBrowse link
G Ctsk cathepsin K increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of CTSK mRNA CTD PMID:19013360 NCBI chr 2:183,058,586...183,069,551
Ensembl chr 2:183,058,569...183,069,550
JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of CX3CR1 mRNA CTD PMID:19013360 NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of CXCL2 mRNA CTD PMID:19013360 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cyth4 cytohesin 4 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of CYTH4 mRNA CTD PMID:12756304 NCBI chr 7:110,152,232...110,176,741
Ensembl chr 7:110,152,272...110,176,741
JBrowse link
G Dad1 defender against cell death 1 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of DAD1 mRNA CTD PMID:12888634 NCBI chr15:27,677,285...27,697,275
Ensembl chr15:27,677,268...27,697,347
JBrowse link
G Ddx23 DEAD-box helicase 23 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of DDX23 mRNA CTD PMID:12756304 NCBI chr 7:129,797,620...129,814,909
Ensembl chr 7:129,797,614...129,814,949
JBrowse link
G Dgcr2 DiGeorge syndrome critical region gene 2 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of DGCR2 mRNA CTD PMID:12756304 NCBI chr11:83,093,961...83,144,507
Ensembl chr11:83,094,037...83,144,502
JBrowse link
G Dgkz diacylglycerol kinase zeta decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of DGKZ mRNA CTD PMID:12756304 NCBI chr 3:77,904,149...77,946,114
Ensembl chr 3:77,904,150...77,946,099
JBrowse link
G Dhx58 DEXH-box helicase 58 increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of DHX58 mRNA CTD PMID:12756304 NCBI chr10:85,620,352...85,631,776
Ensembl chr10:85,620,357...85,631,525
JBrowse link
G Dicer1 dicer 1 ribonuclease III decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of DICER1 mRNA CTD PMID:12756304 NCBI chr 6:123,627,529...123,692,278
Ensembl chr 6:123,631,250...123,693,965
JBrowse link
G Dspp dentin sialophosphoprotein multiple interactions
increases expression
ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [NFIC protein binds to DSPP promoter]
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of DSPP mRNA; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of DSPP protein
CTD PMID:22228435 NCBI chr14:5,565,562...5,571,669
Ensembl chr14:5,565,629...5,571,672
JBrowse link
G Dstn destrin, actin depolymerizing factor increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of DSTN mRNA CTD PMID:12756304 NCBI chr 3:131,284,647...131,311,361
Ensembl chr 3:131,284,648...131,311,379
JBrowse link
G Dync1li2 dynein, cytoplasmic 1 light intermediate chain 2 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of DYNC1LI2 mRNA CTD PMID:12756304 NCBI chr19:531,783...554,670
Ensembl chr19:531,812...554,670
JBrowse link
G E2f1 E2F transcription factor 1 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of E2F1 mRNA CTD PMID:33645215 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
JBrowse link
G Eef1akmt2 EEF1A lysine methyltransferase 2 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of EEF1AKMT2 mRNA CTD PMID:19013360 NCBI chr 1:187,616,156...187,640,937
Ensembl chr 1:187,500,744...187,640,937
JBrowse link
G Egfl7 EGF-like-domain, multiple 7 increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of EGFL7 mRNA CTD PMID:12756304 NCBI chr 3:9,404,622...9,416,879
Ensembl chr 3:9,407,520...9,416,879
JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 increases activity
multiple interactions
ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of EGLN1 protein
zinc chloride inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of EGLN1 protein]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of EGLN1 protein]
CTD PMID:16579968 PMID:16973622 NCBI chr19:52,867,914...52,907,169
Ensembl chr19:52,869,486...52,907,777
JBrowse link
G Egr1 early growth response 1 multiple interactions ISO 3-cyanoalanine inhibits the reaction [[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Cyclophosphamide] results in increased expression of EGR1 protein]; [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Cyclophosphamide] results in increased expression of EGR1 protein CTD PMID:29129814 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Ehd1 EH-domain containing 1 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of EHD1 mRNA CTD PMID:12756304 NCBI chr 1:203,579,850...203,602,226
Ensembl chr 1:203,579,869...203,602,212
JBrowse link
G Elf4 E74 like ETS transcription factor 4 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of ELF4 mRNA CTD PMID:12756304 NCBI chr  X:127,587,401...127,639,063
Ensembl chr  X:127,590,650...127,630,200
JBrowse link
G Ess2 ess-2 splicing factor homolog decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of ESS2 mRNA CTD PMID:12756304 NCBI chr11:83,075,893...83,085,849
Ensembl chr11:83,075,925...83,084,846
JBrowse link
G Fadd Fas associated via death domain decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of FADD mRNA CTD PMID:12756304 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
JBrowse link
G Fam13a family with sequence similarity 13, member A increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of FAM13A mRNA CTD PMID:12756304 NCBI chr 4:88,056,521...88,155,782
Ensembl chr 4:88,058,403...88,155,860
JBrowse link
G Fcer1a Fc epsilon receptor Ia multiple interactions ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein affects the localization of PRKCB protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein affects the localization of RELA protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein results in increased expression of IL6 mRNA]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein results in increased expression of IL6 protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein results in increased expression of TNF mRNA]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein results in increased expression of TNF protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein results in increased phosphorylation of IKBKB protein]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein affects the localization of RELA protein]]; Zinc Sulfate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein affects the localization of RELA protein]] CTD PMID:16818790 NCBI chr13:85,686,099...85,692,394
Ensembl chr13:85,686,092...85,692,351
JBrowse link
G Fez1 fasciculation and elongation protein zeta 1 increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of FEZ1 mRNA CTD PMID:12756304 NCBI chr 8:36,544,462...36,589,684
Ensembl chr 8:36,544,535...36,589,683
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [IL2 protein results in increased expression of FOS mRNA] CTD PMID:20201035 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Foxo3 forkhead box O3 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of FOXO3 mRNA CTD PMID:12756304 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
JBrowse link
G Frat2 FRAT regulator of WNT signaling pathway 2 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of FRAT2 mRNA CTD PMID:12756304 NCBI chr 1:240,654,120...240,656,685
Ensembl chr 1:240,654,137...240,656,517
JBrowse link
G Fzr1 fizzy and cell division cycle 20 related 1 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of FZR1 mRNA CTD PMID:12756304 NCBI chr 7:8,332,029...8,343,953
Ensembl chr 7:8,332,029...8,343,952
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of G6PD mRNA CTD PMID:12888634 PMID:17018880 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of GADD45A mRNA CTD PMID:33645215 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gata1 GATA binding protein 1 multiple interactions ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [GATA1 protein binds to ZFPM1 protein] CTD PMID:33149232 NCBI chr  X:14,529,706...14,537,530
Ensembl chr  X:14,529,702...14,537,530
JBrowse link
G Gga2 golgi associated, gamma adaptin ear containing, ARF binding protein 2 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of GGA2 mRNA CTD PMID:12756304 NCBI chr 1:176,552,046...176,585,332
Ensembl chr 1:176,552,046...176,585,361
JBrowse link
G Gmip Gem-interacting protein decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of GMIP mRNA CTD PMID:12756304 NCBI chr16:19,600,723...19,614,459
Ensembl chr16:19,600,723...19,614,027
JBrowse link
G Golph3l golgi phosphoprotein 3-like decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of GOLPH3L mRNA CTD PMID:12756304 NCBI chr 2:183,151,941...183,183,094
Ensembl chr 2:183,153,301...183,183,083
JBrowse link
G Gorasp2 golgi reassembly stacking protein 2 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of GORASP2 mRNA CTD PMID:12756304 NCBI chr 3:55,474,448...55,503,570
Ensembl chr 3:55,474,757...55,503,576
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of GSTA1 mRNA CTD PMID:17018880 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
JBrowse link
G H2bc12 H2B clustered histone 12 increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of H2BC12 mRNA CTD PMID:19013360 NCBI chr17:42,485,746...42,486,126 JBrowse link
G H2bc9 H2B clustered histone 9 increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of H2BC9 mRNA CTD PMID:19013360 NCBI chr17:42,470,593...42,478,605 JBrowse link
G H4f3 H1.3 linker histone, cluster member increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of H1-3 mRNA CTD PMID:19013360 NCBI chr17:41,528,576...41,554,586
Ensembl chr17:41,529,667...41,552,334
JBrowse link
G Hax1 HCLS1 associated protein X-1 increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of HAX1 mRNA CTD PMID:17622302 NCBI chr 2:175,434,242...175,437,926
Ensembl chr 2:175,434,238...175,437,714
JBrowse link
G Hic2 HIC ZBTB transcriptional repressor 2 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of HIC2 mRNA CTD PMID:12756304 NCBI chr11:83,737,075...83,789,554
Ensembl chr11:83,738,874...83,767,484
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases expression
ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [HIF1A protein binds to CREBBP protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased ubiquitination of and results in increased expression of HIF1A protein; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased stability of and results in increased expression of HIF1A protein; zinc chloride inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased stability of and results in increased expression of HIF1A protein]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased stability of and results in increased expression of HIF1A protein]
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of HIF1A protein
CTD PMID:16579968 PMID:16973622 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hist1h2bd histone cluster 1 H2B family member D increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of H2BC5 mRNA CTD PMID:19013360 NCBI chr17:42,792,887...42,793,268 JBrowse link
G Hist2h2aa3 histone cluster 2 H2A family member A3 increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of H2AC18 mRNA CTD PMID:19013360 NCBI chr 2:183,808,398...183,808,922 JBrowse link
G Hlx H2.0-like homeobox decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of HLX mRNA CTD PMID:12756304 NCBI chr13:96,280,335...96,285,750
Ensembl chr13:96,280,339...96,285,750
JBrowse link
G Hmox2 heme oxygenase 2 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of HMOX2 mRNA CTD PMID:12888634 NCBI chr10:10,797,076...10,831,178
Ensembl chr10:10,797,055...10,831,148
JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha decreases activity
multiple interactions
ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased activity of HNF4A protein
Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased activity of HNF4A protein]
CTD PMID:19637192 NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320
JBrowse link
G Hnmt histamine N-methyltransferase increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of HNMT mRNA CTD PMID:12756304 NCBI chr 3:6,591,804...6,623,821
Ensembl chr 3:6,591,463...6,624,012
JBrowse link
G Ifi27 interferon, alpha-inducible protein 27 increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of IFI27 mRNA CTD PMID:12756304 NCBI chr 6:122,590,461...122,596,996
Ensembl chr 6:122,590,472...122,779,294
JBrowse link
G Ifng interferon gamma multiple interactions ISO [IFNG protein co-treated with TNF protein co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased activity of CASP3 protein; [IFNG protein co-treated with TNF protein co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased cleavage of CDH1 protein; [IFNG protein co-treated with TNF protein co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased cleavage of CTNNB1 protein; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc results in increased secretion of IFNG protein]; Zinc inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased cleavage of CDH1 protein]; Zinc inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased cleavage of CTNNB1 protein] CTD PMID:16844947 PMID:17150331 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Ifngr1 interferon gamma receptor 1 increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of IFNGR1 mRNA CTD PMID:19013360 NCBI chr 1:14,333,167...14,351,799
Ensembl chr 1:14,333,187...14,351,785
JBrowse link
G Ifngr2 interferon gamma receptor 2 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of IFNGR2 mRNA CTD PMID:12756304 NCBI chr11:30,779,733...30,798,005
Ensembl chr11:30,779,733...30,798,005
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions EXP N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein] CTD PMID:14644152 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions EXP N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein] CTD PMID:14644152 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein results in increased phosphorylation of IKBKB protein] CTD PMID:16818790 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
JBrowse link
G Il10 interleukin 10 multiple interactions
decreases expression
ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc results in decreased secretion of IL10 protein]
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of IL10 mRNA
CTD PMID:17150331 PMID:19013360 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il10ra interleukin 10 receptor subunit alpha increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of IL10RA mRNA CTD PMID:19013360 NCBI chr 8:45,563,009...45,578,041
Ensembl chr 8:45,563,137...45,578,061
JBrowse link
G Il10rb interleukin 10 receptor subunit beta increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of IL10RB mRNA CTD PMID:19013360 NCBI chr11:30,646,494...30,668,081
Ensembl chr11:30,652,096...30,668,074
JBrowse link
G Il13ra1 interleukin 13 receptor subunit alpha 1 increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of IL13RA1 mRNA CTD PMID:19013360 NCBI chr  X:115,348,860...115,408,682
Ensembl chr  X:115,348,860...115,408,681
JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of IL1B mRNA
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of IL1B protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [[Lipopolysaccharides co-treated with Nigericin] results in increased cleavage of IL1B protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [[Lipopolysaccharides co-treated with Nigericin] results in increased secretion of IL1B protein]; zinc chloride inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased secretion of IL1B protein]]
CTD PMID:17622302 PMID:19130485 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 multiple interactions ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [IL2 protein results in increased expression of FOS mRNA]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK1 protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK3 protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [IL2 protein results in increased phosphorylation of STAT5A protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [IL2 protein results in increased phosphorylation of STAT5B protein] CTD PMID:20201035 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il4 interleukin 4 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of IL4 mRNA CTD PMID:19013360 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il4r interleukin 4 receptor decreases expression
increases expression
ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of IL4R mRNA
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of IL4R mRNA
CTD PMID:12756304 PMID:19013360 NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980
JBrowse link
G Il6 interleukin 6 increases secretion
multiple interactions
ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased secretion of IL6 protein
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein results in increased expression of IL6 mRNA]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein results in increased expression of IL6 protein]
CTD PMID:16818790 PMID:18615482 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Il6r interleukin 6 receptor increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of IL6R mRNA CTD PMID:19013360 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
JBrowse link
G Ints6 integrator complex subunit 6 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of INTS6 mRNA CTD PMID:12756304 NCBI chr15:36,908,966...37,048,043
Ensembl chr15:36,933,724...37,021,527
JBrowse link
G Iqgap2 IQ motif containing GTPase activating protein 2 increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of IQGAP2 mRNA CTD PMID:19013360 NCBI chr 2:26,894,836...27,170,270
Ensembl chr 2:26,894,825...27,170,279
JBrowse link
G Irf1 interferon regulatory factor 1 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of IRF1 mRNA CTD PMID:12756304 NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166
JBrowse link
G Isg15 ISG15 ubiquitin-like modifier increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of ISG15 mRNA CTD PMID:19013360 NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435
JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO [Zinc co-treated with pyrithione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Calcitriol results in increased expression of ITGAM protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Calcitriol results in increased expression of ITGAM protein]; parthenolide promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Calcitriol results in increased expression of ITGAM protein]]; pyrithione promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Calcitriol results in increased expression of ITGAM protein]] CTD PMID:20089671 NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503
JBrowse link
G Itsn2 intersectin 2 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of ITSN2 mRNA CTD PMID:12756304 NCBI chr 6:27,616,645...27,727,373
Ensembl chr 6:27,600,406...27,727,124
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc results in increased activity of JUN protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc Sulfate results in increased activity of JUN protein] CTD PMID:16606632 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Kat6a lysine acetyltransferase 6A decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of KAT6A mRNA CTD PMID:12756304 NCBI chr16:69,084,914...69,165,923
Ensembl chr16:69,084,914...69,163,606
JBrowse link
G Kazn kazrin, periplakin interacting protein decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of KAZN mRNA CTD PMID:12756304 NCBI chr 5:154,392,793...155,381,567
Ensembl chr 5:154,392,793...154,779,074
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [dexamethasone 21-methanesulfonate binds to KEAP1 protein] CTD PMID:15865434 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Kif23 kinesin family member 23 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of KIF23 mRNA CTD PMID:12888634 NCBI chr 8:62,397,908...62,425,162
Ensembl chr 8:62,397,948...62,425,072
JBrowse link
G Krt8 keratin 8 increases expression
multiple interactions
ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of KRT8 mRNA
TP53 mutant form inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of KRT8 mRNA]
CTD PMID:18778698 NCBI chr 7:133,124,203...133,131,656
Ensembl chr 7:133,124,203...133,131,728
JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 decreases expression
multiple interactions
ISO
EXP
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of LAMP2 mRNA
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Ethambutol results in increased expression of LAMP2 protein]
CTD PMID:12888634 PMID:19063910 NCBI chr  X:117,173,097...117,222,090
Ensembl chr  X:117,057,606...117,260,522
JBrowse link
G Lats2 large tumor suppressor kinase 2 decreases expression
multiple interactions
ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of LATS2 mRNA
TP53 mutant form inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of LATS2 mRNA]
CTD PMID:18778698 NCBI chr15:31,825,068...31,877,193
Ensembl chr15:31,825,092...31,877,220
JBrowse link
G Lig3 DNA ligase 3 increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of LIG3 mRNA CTD PMID:33645215 NCBI chr10:67,717,796...67,741,141
Ensembl chr10:67,717,812...67,798,414
JBrowse link
G Lilra5 leukocyte immunoglobulin like receptor A5 increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of LILRA5 mRNA CTD PMID:19013360 NCBI chr 1:69,973,292...69,978,750
Ensembl chr 1:69,973,292...70,001,718
JBrowse link
G LOC100125598 metallothionein 1a pseudogene decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of MT1G mRNA CTD PMID:19013360 NCBI chr17:74,786,652...74,787,040
Ensembl chr17:74,786,654...74,787,135
JBrowse link
G LOC684819 similar to H3 histone, family 2 isoform 2 increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of H3C11 mRNA CTD PMID:19013360
G Lta lymphotoxin alpha increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of LTA mRNA CTD PMID:12888634 NCBI chr20:3,618,853...3,621,324
Ensembl chr20:3,618,853...3,620,859
JBrowse link
G Mad2l1bp MAD2L1 binding protein decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of MAD2L1BP mRNA CTD PMID:12756304 NCBI chr 9:14,832,133...14,836,458
Ensembl chr 9:14,832,132...14,837,447
JBrowse link
G Map2k5 mitogen activated protein kinase kinase 5 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of MAP2K5 mRNA CTD PMID:12888634 NCBI chr 8:63,625,220...63,852,090
Ensembl chr 8:63,625,221...63,851,983
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK1 protein]
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [2,2'-dipyridyl disulfide results in increased phosphorylation of and results in increased activity of MAPK1 protein]
CTD PMID:11331359 PMID:20201035 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK3 protein] CTD PMID:20201035 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapkbp1 mitogen activated protein kinase binding protein 1 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of MAPKBP1 mRNA CTD PMID:12756304 NCBI chr 3:106,947,342...106,998,368
Ensembl chr 3:106,947,827...106,996,199
JBrowse link
G Mbnl2 muscleblind-like splicing regulator 2 increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of MBNL2 mRNA CTD PMID:12756304 NCBI chr15:97,385,238...97,542,924
Ensembl chr15:97,385,244...97,542,937
JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of MDM2 mRNA CTD PMID:33645215 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Mmp10 matrix metallopeptidase 10 increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of MMP10 mRNA CTD PMID:12888634 NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Glutathione binds to MMP9 protein] CTD PMID:17015178 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mrpl12 mitochondrial ribosomal protein L12 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of MRPL12 mRNA CTD PMID:19013360 NCBI chr10:105,758,410...105,762,913
Ensembl chr10:105,758,410...105,762,913
JBrowse link
G Mt1 metallothionein 1 multiple interactions ISO
EXP
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene results in increased expression of MT1 mRNA]
[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Zinc co-treated with ochratoxin A] results in increased expression of MT1A mRNA; [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Zinc] results in increased expression of MT1A mRNA; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Nitroprusside results in increased expression of MT1A mRNA]
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Glucose results in increased expression of MT1A mRNA]
CTD PMID:14617770 PMID:17018880 PMID:19720134 PMID:23056475 NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO
EXP
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene results in increased expression of MT2 mRNA]
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Glucose results in increased expression of MT2A mRNA]
[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Zinc co-treated with ochratoxin A] results in increased expression of MT2A mRNA; [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Zinc] results in increased expression of MT2A mRNA; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Nickel results in increased expression of MT2A mRNA]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Nitroprusside results in increased expression of MT2A mRNA]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc results in increased expression of MT2A mRNA]
CTD PMID:14617770 PMID:17018880 PMID:19097988 PMID:19720134 PMID:23056475 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
JBrowse link
G Mtf1 metal-regulatory transcription factor 1 multiple interactions
increases expression
ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Nitroprusside results in increased expression of MTF1 mRNA]
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [MTF1 protein binds to SLC39A10 promoter]
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of MTF1 mRNA
CTD PMID:12756304 PMID:12888634 PMID:17018880 PMID:21738690 NCBI chr 5:137,062,319...137,107,136
Ensembl chr 5:137,062,376...137,107,136
JBrowse link
G Mttp microsomal triglyceride transfer protein decreases expression
multiple interactions
ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of MTTP protein
Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of MTTP protein]
CTD PMID:19637192 NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239
JBrowse link
G Mtx1 Metaxin 1 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of MTX1 mRNA CTD PMID:33645215 NCBI chr 2:174,615,460...174,621,383
Ensembl chr 2:174,615,461...174,620,982
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of MYC mRNA CTD PMID:19013360 PMID:33645215 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of MYD88 mRNA CTD PMID:17622302 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
JBrowse link
G Nab2 Ngfi-A binding protein 2 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of NAB2 mRNA CTD PMID:12756304 NCBI chr 7:63,497,589...63,504,105
Ensembl chr 7:63,497,589...63,503,989
JBrowse link
G Ncbp2 nuclear cap binding protein subunit 2 increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of NCBP2 mRNA CTD PMID:12756304 NCBI chr11:68,821,026...68,829,863
Ensembl chr11:68,817,740...68,851,885
JBrowse link
G Ncln nicalin decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of NCLN mRNA CTD PMID:12756304 NCBI chr 7:8,211,978...8,221,938
Ensembl chr 7:8,211,996...8,221,934
JBrowse link
G Nfic nuclear factor I/C multiple interactions
increases expression
ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [NFIC protein binds to DSPP promoter]
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of NFIC protein
CTD PMID:22228435 NCBI chr 7:8,278,210...8,309,936
Ensembl chr 7:8,253,361...8,309,936
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
affects localization
ISO Copper inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine affects the localization of NFKB1 protein]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine affects the localization of NFKB1 protein] CTD PMID:18615482 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
increases degradation
decreases expression
ISO Copper inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased degradation of NFKBIA protein]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased degradation of NFKBIA protein]
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of NFKBIA mRNA
CTD PMID:12756304 PMID:18615482 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nkx3-2 NK3 homeobox 2 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of NKX3-2 mRNA CTD PMID:12756304 NCBI chr14:69,183,795...69,186,182
Ensembl chr14:69,183,820...69,186,061
JBrowse link
G Nlgn1 neuroligin 1 increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of NLGN1 mRNA CTD PMID:12756304 NCBI chr 2:108,256,236...109,181,530
Ensembl chr 2:108,257,824...109,002,464
JBrowse link
G Nlrx1 NLR family member X1 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of NLRX1 mRNA CTD PMID:12756304 NCBI chr 8:44,588,476...44,606,678
Ensembl chr 8:44,590,048...44,606,484
JBrowse link
G Nsmce4a NSE4 homolog A, SMC5-SMC6 complex component decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of NSMCE4A mRNA CTD PMID:12756304 NCBI chr 1:185,102,075...185,109,166
Ensembl chr 1:185,094,360...185,109,166
JBrowse link
G Nup50 nucleoporin 50 increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of NUP50 mRNA CTD PMID:12756304 NCBI chr 7:116,047,960...116,065,231
Ensembl chr 7:116,048,021...116,066,905
JBrowse link
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of OGT mRNA CTD PMID:12756304 NCBI chr  X:66,771,278...66,816,148
Ensembl chr  X:66,771,349...66,816,146
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FK 409 promotes the reaction [OPRM1 protein binds to PRKCG protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FK 409 promotes the reaction [OPRM1 protein binds to RAF1 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein binds to RAF1 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to RAF1 protein]] CTD PMID:18652891 PMID:21235400 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
decreases activity
ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [zinc chloride results in increased expression of PARP1 protein]
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased activity of PARP1 protein
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine affects the reaction [chromium hexavalent ion results in increased cleavage of PARP1 protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Hydrogen Peroxide results in increased activity of PARP1 protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc binds to PARP1 protein]
CTD PMID:15966574 PMID:22253048 PMID:24275069 PMID:33645215 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of PIK3C3 mRNA CTD PMID:12756304 NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048
JBrowse link
G Plscr1 phospholipid scramblase 1 increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of PLSCR1 mRNA CTD PMID:12756304 NCBI chr 8:92,784,279...92,804,698
Ensembl chr 8:92,784,356...92,804,692
JBrowse link
G Polb DNA polymerase beta increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of POLB mRNA CTD PMID:33645215 NCBI chr16:69,379,438...69,402,710
Ensembl chr16:69,379,400...69,404,812
JBrowse link
G Polr2a RNA polymerase II subunit A decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of POLR2A mRNA CTD PMID:12756304 NCBI chr10:54,452,438...54,478,486
Ensembl chr10:54,452,441...54,478,455
JBrowse link
G Polr2d RNA polymerase II subunit D decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of POLR2D mRNA CTD PMID:12756304 NCBI chr18:23,418,097...23,425,228
Ensembl chr18:23,418,097...23,425,228
JBrowse link
G Pon2 paraoxonase 2 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of PON2 mRNA CTD PMID:12888634 NCBI chr 4:33,389,702...33,425,186
Ensembl chr 4:33,389,714...33,425,248
JBrowse link
G Pou4f2 POU class 4 homeobox 2 increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of POU4F2 mRNA CTD PMID:12756304 NCBI chr19:29,486,686...29,490,327
Ensembl chr19:29,486,686...29,490,327
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases activity
multiple interactions
ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased activity of PPARA protein
Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased activity of PPARA protein]
CTD PMID:19637192 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Ppp2r2d protein phosphatase 2, regulatory subunit B, delta decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of PPP2R2D mRNA CTD PMID:12756304 NCBI chr 1:193,665,918...193,700,277
Ensembl chr 1:193,665,855...193,700,274
JBrowse link
G Prkcb protein kinase C, beta multiple interactions ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein affects the localization of PRKCB protein] CTD PMID:16818790 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
JBrowse link
G Prkcg protein kinase C, gamma multiple interactions ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FK 409 promotes the reaction [OPRM1 protein binds to PRKCG protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [S-Nitroso-N-Acetylpenicillamine promotes the reaction [OPRM1 protein binds to PRKCG protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein binds to RAF1 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein]] CTD PMID:18652891 PMID:21235400 NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384
JBrowse link
G Psmb2 proteasome 20S subunit beta 2 increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of PSMB2 mRNA CTD PMID:12756304 NCBI chr 5:138,970,564...139,002,715
Ensembl chr 5:138,970,533...139,021,137
JBrowse link
G Ptcra pre T-cell antigen receptor alpha increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of PTCRA mRNA CTD PMID:19013360 NCBI chr 9:14,218,366...14,229,141
Ensembl chr 9:14,218,802...14,229,235
JBrowse link
G Pth1r parathyroid hormone 1 receptor multiple interactions ISO [zinc chloride deficiency co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in decreased expression of PTH1R mRNA CTD PMID:19913120 NCBI chr 8:110,693,910...110,725,458
Ensembl chr 8:110,697,485...110,719,729
JBrowse link
G Ptp4a1 protein tyrosine phosphatase 4A1 increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of PTP4A1 mRNA CTD PMID:12756304 NCBI chr 9:33,214,201...33,245,046
Ensembl chr 9:33,214,208...33,221,964
JBrowse link
G Ptprn protein tyrosine phosphatase, receptor type, N increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of PTPRN mRNA CTD PMID:17622302 PMID:19013360 NCBI chr 9:76,741,010...76,756,704
Ensembl chr 9:76,741,016...76,756,190
JBrowse link
G Pus1 pseudouridine synthase 1 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of PUS1 mRNA CTD PMID:12756304 NCBI chr12:45,880,364...45,889,196
Ensembl chr12:45,880,440...45,889,196
JBrowse link
G Qrich1 glutamine-rich 1 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of QRICH1 mRNA CTD PMID:12756304 NCBI chr 8:109,216,900...109,256,472
Ensembl chr 8:109,217,376...109,261,359
JBrowse link
G Rad51 RAD51 recombinase increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of RAD51 mRNA CTD PMID:12888634 NCBI chr 3:106,099,753...106,125,038
Ensembl chr 3:106,100,381...106,125,035
JBrowse link
G Rad51c RAD51 paralog C increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of RAD51C mRNA CTD PMID:12756304 NCBI chr10:72,205,032...72,231,643
Ensembl chr10:72,205,032...72,231,248
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FK 409 promotes the reaction [OPRM1 protein binds to RAF1 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to PRKCG protein binds to RAF1 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc promotes the reaction [OPRM1 protein binds to RAF1 protein]] CTD PMID:21235400 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Rb1 RB transcriptional corepressor 1 increases expression
multiple interactions
ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of RB1 mRNA
TP53 mutant form inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of RB1 mRNA]
CTD PMID:18778698 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc results in decreased activity of RELA protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc Sulfate results in decreased activity of RELA protein]
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein affects the localization of RELA protein]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein affects the localization of RELA protein]]; Zinc Sulfate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein affects the localization of RELA protein]]
CTD PMID:16606632 PMID:16818790 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Repin1 replication initiator 1 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of REPIN1 mRNA CTD PMID:12756304 NCBI chr 4:77,548,722...77,554,242
Ensembl chr 4:77,548,849...77,554,257
JBrowse link
G RGD1564804 similar to chromosome 1 open reading frame 50 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of C1ORF50 mRNA CTD PMID:12756304 NCBI chr 5:132,837,135...132,841,744
Ensembl chr 5:132,836,506...132,841,762
JBrowse link
G Rgp1 RGP1 homolog, RAB6A GEF complex partner 1 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of RGP1 mRNA CTD PMID:12756304 NCBI chr 5:57,834,467...57,843,087
Ensembl chr 5:57,834,629...57,843,086
JBrowse link
G Rims2 regulating synaptic membrane exocytosis 2 increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of RIMS2 mRNA CTD PMID:12756304 NCBI chr 7:70,248,104...70,759,134
Ensembl chr 7:70,243,872...70,757,491
JBrowse link
G Rnf187 ring finger protein 187 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of RNF187 mRNA CTD PMID:12756304 NCBI chr10:43,709,493...43,715,392
Ensembl chr10:43,702,357...43,716,157
JBrowse link
G Ror1 receptor tyrosine kinase-like orphan receptor 1 increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of ROR1 mRNA CTD PMID:12756304 NCBI chr 5:114,744,311...115,088,155
Ensembl chr 5:114,744,304...115,088,155
JBrowse link
G Rpl10 ribosomal protein L10 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of RPL10 mRNA CTD PMID:19013360 NCBI chr  X:152,054,547...152,056,757
Ensembl chr  X:152,054,452...152,056,761
JBrowse link
G Rprm reprimo, TP53 dependent G2 arrest mediator homolog increases expression
multiple interactions
ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of RPRM mRNA
TP53 mutant form inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of RPRM mRNA]
CTD PMID:18778698 NCBI chr 3:38,539,581...38,540,998
Ensembl chr 3:38,539,581...38,540,998
JBrowse link
G Rps6ka2 ribosomal protein S6 kinase A2 increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of RPS6KA2 mRNA CTD PMID:19013360 NCBI chr 1:52,631,582...52,906,739
Ensembl chr 1:52,631,736...52,906,739
JBrowse link
G Rrh retinal pigment epithelium derived rhodopsin homolog increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of RRH mRNA CTD PMID:19013360 NCBI chr 2:218,362,195...218,375,202
Ensembl chr 2:218,362,200...218,374,599
JBrowse link
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of RRM2B mRNA CTD PMID:33645215 NCBI chr 7:69,077,024...69,108,742
Ensembl chr 7:69,078,291...69,108,633
JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions ISO [zinc chloride co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased expression of RUNX2 protein; [zinc chloride deficiency co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in decreased expression of RUNX2 mRNA; [zinc chloride deficiency co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in decreased expression of RUNX2 protein CTD PMID:19913120 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
JBrowse link
G S100a4 S100 calcium-binding protein A4 increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of S100A4 mRNA CTD PMID:19013360 NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254
JBrowse link
G S100a6 S100 calcium binding protein A6 increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of S100A6 mRNA CTD PMID:19013360 NCBI chr 2:176,100,619...176,102,181
Ensembl chr 2:176,100,899...176,102,180
JBrowse link
G S100a8 S100 calcium binding protein A8 increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of S100A8 mRNA CTD PMID:19013360 NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643
JBrowse link
G S100a9 S100 calcium binding protein A9 increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of S100A9 mRNA CTD PMID:19013360 NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230
JBrowse link
G Scg3 secretogranin III increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SCG3 mRNA CTD PMID:19013360 NCBI chr 8:76,399,777...76,442,015
Ensembl chr 8:76,399,777...76,442,015
JBrowse link
G Sec16a SEC16 homolog A, endoplasmic reticulum export factor decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of SEC16A mRNA CTD PMID:12756304 NCBI chr 3:9,229,687...9,264,837
Ensembl chr 3:9,229,687...9,264,273
JBrowse link
G Sesn1 sestrin 1 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of SESN1 mRNA CTD PMID:12756304 NCBI chr20:45,294,876...45,387,698
Ensembl chr20:45,294,871...45,387,697
JBrowse link
G Sfn stratifin increases expression
multiple interactions
ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SFN mRNA
TP53 mutant form inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SFN mRNA]
CTD PMID:18778698 Ensembl chr 5:145,826,201...145,831,314 JBrowse link
G Sidt2 SID1 transmembrane family, member 2 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of SIDT2 mRNA CTD PMID:12756304 NCBI chr 8:46,232,379...46,248,913
Ensembl chr 8:46,232,383...46,248,700
JBrowse link
G Slc11a2 solute carrier family 11 member 2 increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SLC11A2 mRNA CTD PMID:19083439 NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145
JBrowse link
G Slc25a39 solute carrier family 25, member 39 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of SLC25A39 mRNA CTD PMID:19013360 NCBI chr10:87,362,494...87,367,358
Ensembl chr10:87,362,490...87,367,260
JBrowse link
G Slc30a1 solute carrier family 30 member 1 decreases expression
multiple interactions
ISO
EXP
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of SLC30A1 mRNA
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Glucose results in increased expression of SLC30A1 mRNA]
[Zinc co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased expression of SLC30A1 mRNA; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Nitroprusside results in increased expression of SLC30A1 mRNA]; ochratoxin A promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of SLC30A1 mRNA]; Zinc inhibits the reaction [ochratoxin A promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of SLC30A1 mRNA]]
CTD PMID:12756304 PMID:17018880 PMID:19720134 PMID:23056475 NCBI chr13:103,491,037...103,494,910
Ensembl chr13:103,491,037...103,494,910
JBrowse link
G Slc30a5 solute carrier family 30 member 5 multiple interactions
increases expression
decreases expression
ISO [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with ochratoxin A] results in decreased expression of SLC30A5 mRNA; [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Zinc] results in decreased expression of SLC30A5 mRNA
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SLC30A5 mRNA
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of SLC30A5 mRNA
CTD PMID:15276077 PMID:17234632 PMID:19720134 NCBI chr 2:31,945,745...31,975,969
Ensembl chr 2:31,945,729...31,975,934
JBrowse link
G Slc30a6 solute carrier family 30 member 6 multiple interactions ISO [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with ochratoxin A] results in decreased expression of SLC30A6 mRNA; [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Zinc] results in increased expression of SLC30A6 mRNA CTD PMID:19720134 NCBI chr 6:21,020,931...21,050,785
Ensembl chr 6:21,020,931...21,050,785
JBrowse link
G Slc30a7 solute carrier family 30 member 7 multiple interactions
increases expression
ISO [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with ochratoxin A co-treated with Zinc] results in decreased expression of SLC30A7 mRNA; [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Zinc] results in increased expression of SLC30A7 mRNA; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [ochratoxin A results in decreased expression of SLC30A7 mRNA]
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SLC30A7 mRNA
CTD PMID:15276077 PMID:17068819 PMID:19720134 NCBI chr 2:203,855,484...203,922,155
Ensembl chr 2:203,859,175...203,922,132
JBrowse link
G Slc30a8 solute carrier family 30 member 8 multiple interactions EXP N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Glucose results in decreased expression of SLC30A8 mRNA] CTD PMID:23056475 NCBI chr 7:83,591,993...83,627,786
Ensembl chr 7:83,591,993...83,626,305
JBrowse link
G Slc39a1 solute carrier family 39 member 1 increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SLC39A1 mRNA CTD PMID:17622302 NCBI chr 2:175,703,413...175,709,063
Ensembl chr 2:175,703,441...175,709,058
JBrowse link
G Slc39a10 solute carrier family 39 member 10 multiple interactions
increases expression
ISO [ochratoxin A co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Zinc] results in decreased expression of SLC39A10 mRNA; [ochratoxin A co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in decreased expression of SLC39A10 mRNA; [Zinc co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in decreased expression of SLC39A10 mRNA
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SLC39A10 mRNA; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SLC39A10 protein
Dactinomycin inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SLC39A10 mRNA]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [MTF1 protein binds to SLC39A10 promoter]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SLC39A10 mRNA]
CTD PMID:19720134 PMID:21738690 NCBI chr 9:54,836,841...54,960,325
Ensembl chr 9:54,876,141...54,960,325
JBrowse link
G Slc39a13 solute carrier family 39 member 13 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of SLC39A13 mRNA CTD PMID:22228435 NCBI chr 3:77,039,411...77,047,536
Ensembl chr 3:77,037,565...77,049,226
JBrowse link
G Slc39a14 solute carrier family 39 member 14 multiple interactions ISO [ochratoxin A co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in decreased expression of SLC39A14 mRNA CTD PMID:19720134 NCBI chr15:45,376,806...45,423,549
Ensembl chr15:45,376,917...45,423,524
JBrowse link
G Slc39a2 solute carrier family 39 member 2 decreases expression
increases expression
ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of SLC39A2 mRNA
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SLC39A2 mRNA
CTD PMID:12756304 PMID:18385089 NCBI chr15:24,590,738...24,592,850
Ensembl chr15:24,590,738...24,592,850
JBrowse link
G Slc39a4 solute carrier family 39 member 4 increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SLC39A4 mRNA CTD PMID:18020946 PMID:19083439 NCBI chr 7:108,333,380...108,337,553
Ensembl chr 7:108,333,381...108,337,553
JBrowse link
G Slc39a5 solute carrier family 39 member 5 decreases response to substance ISO SLC39A5 protein results in decreased susceptibility to N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine CTD PMID:15322118 NCBI chr 7:822,873...830,865
Ensembl chr 7:824,818...830,242
JBrowse link
G Slc39a6 solute carrier family 39 member 6 multiple interactions ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in decreased expression of BCL2 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in decreased expression of BCL2L1 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in increased cleavage of CASP3 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in increased expression of BAX protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form results in decreased susceptibility to trichostatin A]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in decreased expression of BCL2 protein]]]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in decreased expression of BCL2L1 protein]]]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in increased cleavage of CASP3 protein]]]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form inhibits the reaction [trichostatin A results in increased expression of BAX protein]]]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [SLC39A6 mutant form results in decreased susceptibility to trichostatin A]] CTD PMID:19887557 NCBI chr18:15,864,874...15,885,417
Ensembl chr18:15,864,875...15,885,417
JBrowse link
G Slc7a1 solute carrier family 7 member 1 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of SLC7A1 mRNA CTD PMID:12756304 NCBI chr12:6,628,214...6,703,849
Ensembl chr12:6,628,007...6,703,849
JBrowse link
G Slc9a6 solute carrier family 9 member A6 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of SLC9A6 mRNA CTD PMID:12756304 NCBI chr  X:134,430,588...134,486,747
Ensembl chr  X:134,420,756...134,485,375
JBrowse link
G Slco1c1 solute carrier organic anion transporter family, member 1c1 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of SLCO1C1 mRNA CTD PMID:17622302 PMID:19013360 NCBI chr 4:174,466,621...174,513,290
Ensembl chr 4:174,466,631...174,513,289
JBrowse link
G Smim7 small integral membrane protein 7 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of SMIM7 mRNA CTD PMID:12756304 NCBI chr16:17,274,417...17,278,336
Ensembl chr16:17,273,258...17,278,336
JBrowse link
G Snap25 synaptosome associated protein 25 multiple interactions ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Botulinum Toxins, Type A results in increased cleavage of SNAP25 protein] CTD PMID:11181932 NCBI chr 3:124,041,898...124,123,761
Ensembl chr 3:124,041,898...124,123,760
JBrowse link
G Sod1 superoxide dismutase 1 increases expression
multiple interactions
ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SOD1 mRNA
[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine binds to Zinc] inhibits the reaction [SOD1 protein binds to Oligodeoxyribonucleotides]
CTD PMID:12888634 PMID:31162603 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Spen spen family transcriptional repressor decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of SPEN mRNA CTD PMID:12756304 NCBI chr 5:153,775,287...153,848,677
Ensembl chr 5:153,776,234...153,848,811
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions ISO [zinc chloride co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased expression of SPP1 mRNA; [zinc chloride deficiency co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in decreased expression of SPP1 mRNA CTD PMID:19913120 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc results in increased phosphorylation of SRC protein] CTD PMID:12972402 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Srsf5 serine and arginine rich splicing factor 5 increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SRSF5 mRNA CTD PMID:12756304 NCBI chr 6:100,605,165...100,610,192
Ensembl chr 6:100,605,456...100,610,177
JBrowse link
G Stat1 signal transducer and activator of transcription 1 increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of STAT1 mRNA CTD PMID:19013360 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases expression
multiple interactions
ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of STAT3 mRNA
TP53 mutant form inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of STAT3 mRNA]
CTD PMID:18778698 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Stat5a signal transducer and activator of transcription 5A multiple interactions ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [IL2 protein results in increased phosphorylation of STAT5A protein] CTD PMID:20201035 NCBI chr10:85,785,537...85,809,869
Ensembl chr10:85,785,537...85,809,866
JBrowse link
G Stat5b signal transducer and activator of transcription 5B multiple interactions ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [IL2 protein results in increased phosphorylation of STAT5B protein] CTD PMID:20201035 NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668
JBrowse link
G Steap4 STEAP4 metalloreductase increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of STEAP4 mRNA CTD PMID:12756304 NCBI chr 4:26,077,182...26,099,859
Ensembl chr 4:26,054,671...26,099,859
JBrowse link
G Stk10 serine/threonine kinase 10 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of STK10 mRNA CTD PMID:12756304 NCBI chr10:17,117,860...17,212,065
Ensembl chr10:17,117,878...17,212,061
JBrowse link
G Synrg synergin, gamma decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of SYNRG mRNA CTD PMID:12756304 NCBI chr10:68,848,828...68,931,252
Ensembl chr10:68,849,642...68,931,250
JBrowse link
G Tbc1d8 TBC1 domain family, member 8 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of TBC1D8 mRNA CTD PMID:12756304 NCBI chr 9:41,651,394...41,761,432
Ensembl chr 9:41,651,395...41,761,409
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of TGFBR2 mRNA CTD PMID:12756304 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228
JBrowse link
G Thop1 thimet oligopeptidase 1 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of THOP1 mRNA CTD PMID:19013360 NCBI chr 7:8,632,911...8,645,339
Ensembl chr 7:8,632,916...8,645,275
JBrowse link
G Timp3 TIMP metallopeptidase inhibitor 3 increases expression
multiple interactions
ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of TIMP3 mRNA
TP53 mutant form inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of TIMP3 mRNA]
CTD PMID:18778698 NCBI chr 7:17,520,827...17,571,871
Ensembl chr 7:17,521,919...17,571,839
JBrowse link
G Tle1 TLE family member 1, transcriptional corepressor decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of TLE1 mRNA CTD PMID:12756304 NCBI chr 5:85,851,827...85,934,806
Ensembl chr 5:85,851,827...85,934,774
JBrowse link
G Tmem184c transmembrane protein 184C increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of TMEM184C mRNA CTD PMID:12756304 NCBI chr19:30,345,183...30,361,275
Ensembl chr19:30,345,290...30,361,269
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [IFNG protein co-treated with TNF protein co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased activity of CASP3 protein; [IFNG protein co-treated with TNF protein co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased cleavage of CDH1 protein; [IFNG protein co-treated with TNF protein co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased cleavage of CTNNB1 protein; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [[Calcitriol co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased secretion of TNF protein]; Zinc inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased cleavage of CDH1 protein]; Zinc inhibits the reaction [[IFNG protein co-treated with TNF protein co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] results in increased cleavage of CTNNB1 protein]
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein results in increased expression of TNF mRNA]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [FCER1A protein results in increased expression of TNF protein]
CTD PMID:16818790 PMID:16844947 PMID:20089671 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfaip8 TNF alpha induced protein 8 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of TNFAIP8 mRNA CTD PMID:12756304 NCBI chr18:43,183,854...43,299,517
Ensembl chr18:43,183,916...43,299,517
JBrowse link
G Tns3 tensin 3 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of TNS3 mRNA CTD PMID:12756304 NCBI chr14:83,173,649...83,405,671
Ensembl chr14:83,173,649...83,405,998
JBrowse link
G Tp53 tumor protein p53 affects localization
multiple interactions
increases expression
ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine affects the localization of TP53 protein
[Acetylcysteine co-treated with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine] inhibits the reaction [[Zinc Sulfate co-treated with prolinedithiocarbamate] results in decreased expression of TP53 protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [[Zinc Sulfate co-treated with prolinedithiocarbamate] results in decreased expression of TP53 protein]; TP53 mutant form inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of LATS2 mRNA]; TP53 mutant form inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of STAT3 mRNA]; TP53 mutant form inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of KRT8 mRNA]; TP53 mutant form inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of RB1 mRNA]; TP53 mutant form inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of RPRM mRNA]; TP53 mutant form inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SFN mRNA]; TP53 mutant form inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of TIMP3 mRNA]; TP53 mutant form inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of TP73 mRNA]; TP53 mutant form inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of YWHAZ mRNA]
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of TP53 protein
CTD PMID:12888634 PMID:18778698 PMID:18951928 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tp73 tumor protein p73 increases expression
multiple interactions
ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of TP73 mRNA
TP53 mutant form inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of TP73 mRNA]
CTD PMID:18778698 NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128
JBrowse link
G Trak1 trafficking kinesin protein 1 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of TRAK1 mRNA CTD PMID:12756304 NCBI chr 8:120,984,445...121,139,357
Ensembl chr 8:120,984,431...121,139,367
JBrowse link
G Tst thiosulfate sulfurtransferase decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of TST mRNA CTD PMID:12756304 NCBI chr 7:109,948,061...109,955,378
Ensembl chr 7:109,948,062...109,957,216
JBrowse link
G Txnip thioredoxin interacting protein increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of TXNIP mRNA CTD PMID:19013360 NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886
JBrowse link
G Tyms thymidylate synthetase increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of TYMS mRNA CTD PMID:12888634 NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536
JBrowse link
G Ugcg UDP-glucose ceramide glucosyltransferase decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of UGCG mRNA CTD PMID:12756304 NCBI chr 5:74,032,978...74,065,701
Ensembl chr 5:74,032,978...74,065,393
JBrowse link
G Ung uracil-DNA glycosylase increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of UNG mRNA CTD PMID:12888634 NCBI chr12:42,485,276...42,494,217
Ensembl chr12:42,485,276...42,494,206
JBrowse link
G Usp24 ubiquitin specific peptidase 24 decreases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of USP24 mRNA CTD PMID:12756304 NCBI chr 5:121,080,687...121,210,321
Ensembl chr 5:121,080,470...121,210,311
JBrowse link
G Usp5 ubiquitin specific peptidase 5 multiple interactions ISO 3-cyanoalanine inhibits the reaction [[N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Cyclophosphamide] results in increased expression of USP5 protein]; [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine co-treated with Cyclophosphamide] results in increased expression of USP5 protein CTD PMID:29129814 NCBI chr 4:157,619,643...157,634,711
Ensembl chr 4:157,619,643...157,634,711
JBrowse link
G Uvrag UV radiation resistance associated increases expression ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of UVRAG mRNA CTD PMID:12888634 NCBI chr 1:153,185,356...153,442,200
Ensembl chr 1:153,185,395...153,442,136
JBrowse link
G Vdac1 voltage-dependent anion channel 1 decreases expression
increases expression
multiple interactions
EXP N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of VDAC1 mRNA
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of VDAC1 protein
Zinc Sulfate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of VDAC1 mRNA]; Zinc Sulfate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of VDAC1 protein]
CTD PMID:21605504 NCBI chr10:36,532,306...36,559,642
Ensembl chr10:36,532,244...36,559,640
JBrowse link
G Vdac2 voltage-dependent anion channel 2 decreases expression
multiple interactions
EXP N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of VDAC2 mRNA; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of VDAC2 protein
Zinc Sulfate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of VDAC2 mRNA]; Zinc Sulfate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of VDAC2 protein]
CTD PMID:21605504 NCBI chr15:2,462,877...2,476,802
Ensembl chr15:2,463,056...2,476,553
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
increases secretion
ISO N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of VEGFA mRNA
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased secretion of VEGFA protein
CTD PMID:18615482 PMID:20957409 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641