CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: cyanazine
Accession: CHEBI:38069
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Definition: A chloro-1,3,5-triazine that is 2-chloro-1,3,5-triazine substituted by an ethyl amino and a (2-cyanopropan-2-yl)amino group at positions 6 and 4 respectively.
Synonyms: related_synonym: 2-([4-chloro-6-(ethylamino)-1,3,5-triazin-2-yl]amino)-2-methylpropanenitrile; 2-Chloro-4-(1-cyano-1-methylethylamino)-6-ethylamine-1,3,5-triazine; 2-[[4-chloro-6-(ethylamino)-s-triazin-2-yl]amino]-2-methylpropionitrile; 2-chloro-4-(1-cyano-1-methylethylamino)-6-ethylamino-1,3,5-triazine; Bladex; Formula=C9H13ClN6; Fortrol; InChI=1S/C9H13ClN6/c1-4-12-7-13-6(10)14-8(15-7)16-9(2,3)5-11/h4H2,1-3H3,(H2,12,13,14,15,16); InChIKey=MZZBPDKVEFVLFF-UHFFFAOYSA-N; SMILES=CCNc1nc(Cl)nc(NC(C)(C)C#N)n1
alt_id: CHEBI:23421; CHEBI:34658
xref: Beilstein:615509; CAS:21725-46-2; KEGG:C14299
xref_mesh: MESH:C007168
xref: PMID:16882534; PMID:23762632; PMID:24607126; PMID:24631619; PPDB:185; Pesticides:cyanazine; Reaxys:615509; UM-BBD_compID:c0176
G
Adra2a
adrenoceptor alpha 2A
affects binding affects activity
EXP
cyanazine binds to ADRA2A protein cyanazine affects the activity of ADRA2A protein
CTD
PMID:11071396
NCBI chr 1:253,061,480...253,064,280
Ensembl chr 1:253,060,218...253,064,365
G
Dbh
dopamine beta-hydroxylase
increases expression
EXP
cyanazine results in increased expression of DBH protein
CTD
PMID:14550852
NCBI chr 3:10,488,260...10,505,245
Ensembl chr 3:10,488,260...10,505,248
G
Drd2
dopamine receptor D2
affects activity
EXP
cyanazine affects the activity of DRD2 protein
CTD
PMID:11071396
NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875
G
Esr1
estrogen receptor 1
affects binding multiple interactions
ISO
cyanazine binds to ESR1 protein cyanazine inhibits the reaction [Estradiol binds to and results in increased activity of ESR1 protein]
CTD
PMID:8858116
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
G
Esr2
estrogen receptor 2
affects binding
ISO
cyanazine binds to ESR2 protein
CTD
PMID:12224631
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
G
Gper1
G protein-coupled estrogen receptor 1
affects expression
ISO
cyanazine affects the expression of GPER1 mRNA
CTD
PMID:26955487
NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889
G
Pde4a
phosphodiesterase 4A
decreases activity
ISO
cyanazine results in decreased activity of PDE4A protein
CTD
PMID:21251949
NCBI chr 8:19,690,816...19,753,538
Ensembl chr 8:19,703,290...19,751,961
G
Pde5a
phosphodiesterase 5A
affects activity
ISO
cyanazine affects the activity of PDE5 protein
CTD
PMID:21251949
NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701
G
Prl
prolactin
increases expression
EXP
cyanazine metabolite results in increased expression of PRL protein; cyanazine results in increased expression of PRL protein
CTD
PMID:11071396
NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
G
Th
tyrosine hydroxylase
increases expression
EXP
cyanazine results in increased expression of TH protein
CTD
PMID:14550852
NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
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