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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:bepridil
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Accession:CHEBI:3061 term browser browse the term
Definition:A tertiary amine in which the substituents on nitrogen are benzyl, phenyl and 3-(2-methylpropoxy)-2-(pyrrolidin-1-yl)propyl.
Synonyms:exact_synonym: N-benzyl-N-[3-(2-methylpropoxy)-2-(pyrrolidin-1-yl)propyl]aniline
 related_synonym: Bepadin;   Formula=C24H34N2O;   InChI=1S/C24H34N2O/c1-21(2)19-27-20-24(25-15-9-10-16-25)18-26(23-13-7-4-8-14-23)17-22-11-5-3-6-12-22/h3-8,11-14,21,24H,9-10,15-20H2,1-2H3;   InChIKey=UIEATEWHFDRYRU-UHFFFAOYSA-N;   SMILES=CC(C)COCC(CN(Cc1ccccc1)c1ccccc1)N1CCCC1
 xref: Beilstein:5993674;   CAS:64706-54-3;   DrugBank:DB01244;   Drug_Central:342;   KEGG:C06847;   KEGG:D07520;   LINCS:LSM-1898
 xref_mesh: MESH:D015764
 xref: Wikipedia:Bepridil


show annotations for term's descendants           Sort by:
bepridil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO Bepridil inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] CTD PMID:11895100 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO Bepridil results in increased expression of ATF4 protein CTD PMID:21292685 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects metabolic processing ISO CYP3A4 protein affects the metabolism of Bepridil CTD PMID:15286053 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Bepridil results in increased expression of DDIT3 protein CTD PMID:21292685 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases phosphorylation ISO Bepridil results in increased phosphorylation of EIF2A protein CTD PMID:21292685 NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068 		JBrowse link
G Kcna5 potassium voltage-gated channel subfamily A member 5 decreases activity ISO Bepridil results in decreased activity of KCNA5 protein CTD PMID:11711026 NCBI chr 4:159,354,689...159,358,173
Ensembl chr 4:159,350,097...159,357,697 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity		 ISO Bepridil binds to and results in decreased activity of KCNH2 protein; Bepridil inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Bepridil results in decreased activity of KCNH2 protein		 CTD PMID:15272206 PMID:15671647 PMID:21158687 PMID:24052561 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Slc8a1 solute carrier family 8 member A1 multiple interactions ISO Bepridil inhibits the reaction [SLC8A1 protein results in increased susceptibility to Chlorodiphenyl (54% Chlorine)] CTD PMID:16009740 NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628 		JBrowse link
G Tnfsf10 TNF superfamily member 10 increases response to substance ISO Bepridil results in increased susceptibility to TNFSF10 protein CTD PMID:21292685 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19917
    role 19887
      biological role 19885
        pharmacological role 19109
          antagonist 17263
            calcium channel blocker 7169
              bepridil 9
                bepridil hydrochloride 0
                bepridil hydrochloride monohydrate 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19917
    subatomic particle 19915
      composite particle 19915
        hadron 19915
          baryon 19915
            nucleon 19915
              atomic nucleus 19915
                atom 19915
                  main group element atom 19855
                    main group molecular entity 19855
                      s-block molecular entity 19686
                        hydrogen molecular entity 19667
                          hydrides 19173
                            inorganic hydride 18184
                              pnictogen hydride 18174
                                nitrogen hydride 18087
                                  azane 17893
                                    ammonia 17892
                                      organic amino compound 17892
                                        tertiary amino compound 10159
                                          tertiary amine 645
                                            bepridil 9
                                              bepridil hydrochloride 0
                                              bepridil hydrochloride monohydrate 0
paths to the root