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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tertiary amine
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Accession:CHEBI:32876 term browser browse the term
Definition:A compound formally derived from ammonia by replacing three hydrogen atoms by hydrocarbyl groups.
Synonyms:exact_synonym: tertiary amines
 related_synonym: Formula=NR3;   R3N;   SMILES=[*]N([*])[*];   tertiaeres Amin
 alt_id: CHEBI:26879;   CHEBI:9458
 xref: KEGG:C02196


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(-)-lobeline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions ISO [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Lobeline inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Lobeline results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:14645658, PMID:18448488 NCBI chr 3:176,533,182...176,547,965
Ensembl chr 3:176,527,516...176,548,208
JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit affects response to substance
multiple interactions
ISO CHRNA7 protein mutant form affects the susceptibility to Lobeline
Lobeline binds to and results in decreased activity of CHRNA7 protein; Lobeline binds to and results in increased activity of CHRNA7 protein mutant form
CTD PMID:10082212 NCBI chr 1:123,897,341...124,039,263
Ensembl chr 1:123,899,657...124,039,196
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions ISO [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Lobeline inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Lobeline results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:14645658, PMID:18448488 NCBI chr 2:189,088,570...189,096,785
Ensembl chr 2:189,088,570...189,096,785
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Lobeline results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Lobeline inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK1 protein] CTD PMID:18448488, PMID:20106947 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Lobeline inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK3 protein] CTD PMID:18448488, PMID:20106947 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Lobeline inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein] CTD PMID:18448488, PMID:20106947 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
(-)-selegiline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions ISO Selegiline inhibits the reaction [1-Methyl-4-phenylpyridinium affects the localization of AIFM1 protein]; Selegiline inhibits the reaction [Oxidopamine affects the localization of AIFM1 protein]; Selegiline inhibits the reaction [Rotenone affects the localization of AIFM1 protein] CTD PMID:12880480 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Selegiline co-treated with 1-Methyl-4-phenylpyridinium] results in increased phosphorylation of AKT1 protein]; [Selegiline co-treated with 1-Methyl-4-phenylpyridinium] results in increased phosphorylation of AKT1 protein
Selegiline results in increased phosphorylation of AKT1 protein
CTD PMID:22019741 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Bach1 BTB domain and CNC homolog 1 multiple interactions ISO Selegiline inhibits the reaction [Smoke analog affects the localization of BACH1 protein] CTD PMID:28108387 NCBI chr11:27,364,913...27,398,713
Ensembl chr11:27,364,916...27,398,842
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Selegiline inhibits the reaction [linsidomine results in increased expression of BAX protein] CTD PMID:12880480 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO Selegiline inhibits the reaction [linsidomine results in decreased expression of BCL2 protein] CTD PMID:12880480 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions ISO Selegiline inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 mRNA]; Selegiline inhibits the reaction [linsidomine results in increased expression of CASP3 mRNA]; Selegiline inhibits the reaction [linsidomine results in increased expression of CASP3 protein]
Selegiline promotes the reaction [Hydroxyurea results in increased cleavage of CASP3 protein]
CTD PMID:12880480, PMID:14724376, PMID:23696560 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Cat catalase multiple interactions EXP
ISO
Selegiline promotes the reaction [Rotenone results in increased activity of CAT protein]
Selegiline inhibits the reaction [Smoke analog results in decreased activity of CAT protein]
CTD PMID:16490285, PMID:28108387 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO Selegiline inhibits the reaction [linsidomine affects the localization of CYCS protein] CTD PMID:12880480 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects metabolic processing ISO CYP1A2 protein affects the metabolism of Selegiline CTD PMID:16198659 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
decreases activity
ISO Selegiline inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion]
Selegiline results in decreased activity of CYP2B6 protein
CTD PMID:25656918 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Selegiline inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of FOS mRNA] CTD PMID:14724376 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO
EXP
Selegiline inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of GAPDH mRNA]
Selegiline inhibits the reaction [Paraquat affects the localization of GAPDH protein]
Selegiline inhibits the reaction [Hydroxyurea affects the localization of GAPDH protein]
CTD PMID:14724376, PMID:20478973, PMID:23696560 NCBI chr 4:157,676,336...157,680,322
Ensembl chr 4:157,676,595...157,679,962
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Selegiline inhibits the reaction [Smoke analog results in increased expression of HMOX1 protein] CTD PMID:28108387 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO Selegiline inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of JUN mRNA]
Selegiline results in increased expression of JUN protein
CTD PMID:14724376, PMID:16099847 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Maoa monoamine oxidase A decreases activity ISO Selegiline results in decreased activity of MAOA protein CTD PMID:31323226 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722
JBrowse link
G Maob monoamine oxidase B affects binding
decreases activity
multiple interactions
ISO
EXP
Selegiline binds to MAOB protein
Selegiline results in decreased activity of MAOB protein
[Selegiline results in decreased activity of MAOB protein] which results in decreased abundance of 3,4-Dihydroxyphenylacetic Acid; [Selegiline results in decreased activity of MAOB protein] which results in decreased abundance of Homovanillic Acid; [Selegiline results in decreased activity of MAOB protein] which results in increased abundance of Dopamine
[Selegiline results in decreased activity of MAOB protein] which results in increased susceptibility to Methamphetamine; zonisamide inhibits the reaction [Selegiline binds to MAOB protein]
Selegiline inhibits the reaction [MAOB protein results in decreased amination of Dopamine]; Selegiline inhibits the reaction [MAOB protein results in increased degradation of Dopamine]; Selegiline inhibits the reaction [Smoke analog results in increased activity of MAOB protein]
CTD PMID:1905457, PMID:15178694, PMID:15545290, PMID:16012872, PMID:16252076, PMID:19948168, PMID:21405131, PMID:21696156, PMID:21923181, PMID:21923198, PMID:26721607, PMID:28108387, PMID:28302559, PMID:30036687, PMID:31323226 NCBI chr  X:6,430,694...6,533,520
Ensembl chr  X:6,430,594...6,533,534
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO
EXP
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Selegiline results in increased phosphorylation of MAPK1 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Selegiline co-treated with 1-Methyl-4-phenylpyridinium] results in increased phosphorylation of MAPK1 protein]; [Selegiline co-treated with 1-Methyl-4-phenylpyridinium] results in increased phosphorylation of MAPK1 protein
CTD PMID:16099847, PMID:22019741 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO
EXP
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Selegiline results in increased phosphorylation of MAPK3 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Selegiline co-treated with 1-Methyl-4-phenylpyridinium] results in increased phosphorylation of MAPK3 protein]; [Selegiline co-treated with 1-Methyl-4-phenylpyridinium] results in increased phosphorylation of MAPK3 protein
CTD PMID:16099847, PMID:22019741 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mt1 metallothionein 1 multiple interactions ISO Selegiline inhibits the reaction [linsidomine results in increased expression of MT1 protein] CTD PMID:12880480 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases phosphorylation
multiple interactions
ISO Selegiline results in increased phosphorylation of MYC protein
MYC protein affects the reaction [Selegiline results in increased expression of TXN]
CTD PMID:16099847 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
increases localization
EXP
ISO
NFE2L2 mutant form inhibits the reaction [Selegiline inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased activity of NQO1 protein]]; NFE2L2 mutant form inhibits the reaction [Selegiline results in increased activity of NQO1 protein]; Selegiline inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased localization of NFE2L2 protein]
Selegiline inhibits the reaction [Smoke analog affects the localization of NFE2L2 protein]
Selegiline results in increased localization of NFE2L2 protein
CTD PMID:22019741, PMID:28108387 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases activity
EXP
ISO
NFE2L2 mutant form inhibits the reaction [Selegiline inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased activity of NQO1 protein]]; NFE2L2 mutant form inhibits the reaction [Selegiline results in increased activity of NQO1 protein]; Selegiline inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased activity of NQO1 protein]
Selegiline inhibits the reaction [Smoke analog results in increased expression of NQO1 protein]
CTD PMID:22019741, PMID:28108387 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Selegiline inhibits the reaction [linsidomine results in decreased expression of PARP1 protein] CTD PMID:12880480 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions ISO Selegiline inhibits the reaction [linsidomine results in increased expression of PRKN protein] CTD PMID:12880480 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Selegiline inhibits the reaction [Smoke analog affects the localization of RELA protein] CTD PMID:28108387 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Siah1 siah E3 ubiquitin protein ligase 1 multiple interactions EXP Selegiline inhibits the reaction [Paraquat affects the localization of SIAH1A protein] CTD PMID:20478973 NCBI chr19:21,372,163...21,395,773
Ensembl chr19:21,372,163...21,395,767
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Selegiline inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Snca synuclein alpha multiple interactions ISO Selegiline inhibits the reaction [1,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline results in increased expression of SNCA protein]; Selegiline inhibits the reaction [linsidomine results in increased expression of SNCA protein] CTD PMID:12880480, PMID:15114628 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Th tyrosine hydroxylase multiple interactions
decreases expression
EXP Selegiline inhibits the reaction [Rotenone results in decreased expression of TH protein]
Selegiline results in decreased expression of TH mRNA
CTD PMID:11862330, PMID:16490285 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
JBrowse link
G Txn1 thioredoxin 1 multiple interactions
increases expression
affects response to substance
ISO Dinitrochlorobenzene inhibits the reaction [Selegiline results in increased expression of TXN]; Dinitrochlorobenzene inhibits the reaction [TXN protein affects the susceptibility to Selegiline]; MYC protein affects the reaction [Selegiline results in increased expression of TXN]
Selegiline results in increased expression of TXN protein
CTD PMID:16099847 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
(Z)-chlorprothixene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions ISO Chlorprothixene inhibits the reaction [(2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane binds to HTR1A protein] CTD PMID:2891550 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Chlorprothixene results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Prl prolactin increases secretion ISO Chlorprothixene results in increased secretion of PRL protein CTD PMID:10525070 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
almotriptan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases methylation
increases hydroxylation
increases metabolic processing
ISO CYP1A1 protein results in decreased methylation of almotriptan
CYP1A1 protein results in increased hydroxylation of almotriptan
CYP1A1 protein results in increased metabolism of almotriptan
CTD PMID:12642466 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases methylation ISO CYP1A2 protein results in decreased methylation of almotriptan CTD PMID:12642466 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases methylation ISO CYP2C19 protein results in decreased methylation of almotriptan CTD PMID:12642466 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases methylation ISO CYP2C8 protein results in decreased methylation of almotriptan CTD PMID:12642466 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases methylation
increases hydroxylation
ISO CYP2D6 protein results in decreased methylation of almotriptan
CYP2D6 protein results in increased hydroxylation of almotriptan
CTD PMID:12642466 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 increases oxidation ISO FMO3 protein results in increased oxidation of almotriptan CTD PMID:12642466 NCBI chr13:80,837,418...80,856,214
Ensembl chr13:80,837,420...80,862,963
JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B multiple interactions ISO HTR1B affects the reaction [almotriptan inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]] CTD PMID:11134654 NCBI chr 8:89,113,984...89,130,830
Ensembl chr 8:89,129,453...89,130,991
JBrowse link
G Maoa monoamine oxidase A increases metabolic processing ISO MAOA protein results in increased metabolism of almotriptan CTD PMID:12642466 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722
JBrowse link
alverine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htr1a 5-hydroxytryptamine receptor 1A affects binding EXP alverine binds to HTR1A protein CTD PMID:11697552 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO alverine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
amitriptyline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadat aminoadipate aminotransferase affects expression EXP Amitriptyline affects the expression of AADAT mRNA CTD PMID:18355885 NCBI chr16:32,832,001...32,868,680
Ensembl chr16:32,832,061...32,868,702
JBrowse link
G Abat 4-aminobutyrate aminotransferase decreases expression EXP Amitriptyline results in decreased expression of ABAT mRNA CTD PMID:21820738 NCBI chr10:7,093,406...7,200,439
Ensembl chr10:7,093,405...7,200,499
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression EXP Amitriptyline results in decreased expression of ABCB11 mRNA CTD PMID:27765674 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects transport
increases transport
affects expression
ISO
EXP
ABCB1A protein affects the transport of Amitriptyline
ABCB1A protein results in increased transport of Amitriptyline; ABCB1A protein results in increased transport of Amitriptyline metabolite
Amitriptyline affects the expression of ABCB1 mRNA
CTD PMID:10700657, PMID:12082591, PMID:18355885 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcd2 ATP binding cassette subfamily D member 2 decreases expression EXP Amitriptyline results in decreased expression of ABCD2 mRNA CTD PMID:22341215 NCBI chr 7:132,294,564...132,343,169
Ensembl chr 7:132,294,562...132,343,169
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 decreases expression EXP Amitriptyline results in decreased expression of ABCG5 mRNA CTD PMID:27765674 NCBI chr 6:7,935,771...7,961,207
Ensembl chr 6:7,935,771...7,961,207
JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 decreases expression EXP Amitriptyline results in decreased expression of ABCG8 mRNA CTD PMID:27765674 NCBI chr 6:7,961,413...7,980,708
Ensembl chr 6:7,961,413...7,980,708
JBrowse link
G Ache acetylcholinesterase decreases expression
increases activity
EXP
ISO
Amitriptyline results in decreased expression of ACHE mRNA
Amitriptyline results in increased activity of ACHE protein
CTD PMID:21820738, PMID:29614332 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 affects expression EXP Amitriptyline affects the expression of ALDH1A1 mRNA CTD PMID:18355885 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Aldh1a7 aldehyde dehydrogenase family 1, subfamily A7 affects expression EXP Amitriptyline affects the expression of ALDH1A4 mRNA CTD PMID:18355885 NCBI chr 1:240,584,233...240,601,843
Ensembl chr 1:240,562,423...240,601,744
JBrowse link
G Ankrd1 ankyrin repeat domain 1 increases expression EXP Amitriptyline results in increased expression of ANKRD1 mRNA CTD PMID:22341215 NCBI chr 1:254,726,985...254,745,673
Ensembl chr 1:254,726,969...254,735,548
JBrowse link
G Ano3 anoctamin 3 decreases expression EXP Amitriptyline results in decreased expression of ANO3 mRNA CTD PMID:22341215 NCBI chr 3:101,843,516...102,203,368
Ensembl chr 3:101,840,630...102,151,489
JBrowse link
G Ap1s1 adaptor related protein complex 1 subunit sigma 1 decreases expression ISO Amitriptyline results in decreased expression of AP1S1 mRNA CTD PMID:17175557, PMID:17567588 NCBI chr12:22,665,128...22,676,079
Ensembl chr12:22,665,112...22,676,075
JBrowse link
G Apoa4 apolipoprotein A4 affects expression EXP Amitriptyline affects the expression of APOA4 mRNA CTD PMID:18355885 NCBI chr 8:50,536,983...50,539,371
Ensembl chr 8:50,537,009...50,539,376
JBrowse link
G Arg1 arginase 1 increases expression EXP Amitriptyline results in increased expression of ARG1 mRNA CTD PMID:22341215 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 increases expression ISO Amitriptyline results in increased expression of ASAH1 mRNA CTD PMID:15342952, PMID:17175557, PMID:17567588 NCBI chr16:53,998,604...54,030,006
Ensembl chr16:53,998,560...54,040,836
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Amitriptyline results in increased expression of ASNS mRNA CTD PMID:15342952, PMID:17175557, PMID:17567588 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
JBrowse link
G Atf3 activating transcription factor 3 increases expression EXP Amitriptyline results in increased expression of ATF3 mRNA CTD PMID:22341215 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Amitriptyline inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein] CTD PMID:19135049 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Amitriptyline inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein] CTD PMID:19135049 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bhmt betaine-homocysteine S-methyltransferase affects expression EXP Amitriptyline affects the expression of BHMT mRNA CTD PMID:18355885 NCBI chr 2:23,236,573...23,256,158
Ensembl chr 2:23,236,575...23,256,158
JBrowse link
G C1qa complement C1q A chain increases expression EXP Amitriptyline results in increased expression of C1QA mRNA CTD PMID:22341215 NCBI chr 5:155,261,254...155,264,101
Ensembl chr 5:155,261,250...155,264,143
JBrowse link
G C1qc complement C1q C chain increases expression EXP Amitriptyline results in increased expression of C1QC mRNA CTD PMID:22341215 NCBI chr 5:155,255,013...155,258,631
Ensembl chr 5:155,255,005...155,258,392
JBrowse link
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 increases expression EXP Amitriptyline results in increased expression of CACNA2D1 mRNA CTD PMID:22341215 NCBI chr 4:15,706,974...16,130,848
Ensembl chr 4:15,710,417...16,130,848
JBrowse link
G Casp1 caspase 1 multiple interactions ISO Amitriptyline inhibits the reaction [7-ketocholesterol affects the localization of CASP1 protein]; Amitriptyline inhibits the reaction [7-ketocholesterol results in increased activity of CASP1 protein]; Amitriptyline inhibits the reaction [Cholesterol analog affects the localization of CASP1 protein]; Amitriptyline inhibits the reaction [Cholesterol analog results in increased activity of CASP1 protein] CTD PMID:28633109 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity
EXP Amitriptyline inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein]
Amitriptyline results in increased expression of CASP3 mRNA
Amitriptyline results in increased activity of CASP3 protein
CTD PMID:16717317, PMID:19135049, PMID:19815060 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casr calcium-sensing receptor decreases expression EXP Amitriptyline results in decreased expression of CASR mRNA CTD PMID:22341215 NCBI chr11:67,188,204...67,262,261
Ensembl chr11:67,188,630...67,258,771
JBrowse link
G Cat catalase decreases expression ISO Amitriptyline results in decreased expression of CAT protein CTD PMID:1937386 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cd74 CD74 molecule increases expression EXP Amitriptyline results in increased expression of CD74 mRNA CTD PMID:22341215 NCBI chr18:56,071,420...56,080,851
Ensembl chr18:56,071,478...56,080,849
JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C affects expression EXP Amitriptyline affects the expression of CDKN2C mRNA CTD PMID:18355885 NCBI chr 5:129,347,731...129,352,886
Ensembl chr 5:129,347,732...129,352,886
JBrowse link
G Ces2h carboxylesterase 2H affects expression EXP Amitriptyline affects the expression of CES2 mRNA CTD PMID:18355885 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156
JBrowse link
G Chat choline O-acetyltransferase increases expression EXP Amitriptyline results in increased expression of CHAT mRNA CTD PMID:21820738 NCBI chr16:8,576,858...8,686,131
Ensembl chr16:8,577,840...8,686,131
JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit decreases expression EXP Amitriptyline results in decreased expression of CHRNA3 mRNA CTD PMID:22341215 NCBI chr 8:59,594,007...59,607,122
Ensembl chr 8:59,592,403...59,607,275
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit decreases expression
increases response to substance
EXP
ISO
Amitriptyline results in decreased expression of CHRNB2 mRNA
CHRNB2 protein results in increased susceptibility to Amitriptyline
CTD PMID:21820738, PMID:21905669 NCBI chr 2:189,088,570...189,096,785
Ensembl chr 2:189,088,570...189,096,785
JBrowse link
G Cmtm6 CKLF-like MARVEL transmembrane domain containing 6 affects expression EXP Amitriptyline affects the expression of CMTM6 mRNA CTD PMID:18355885 NCBI chr 8:122,789,208...122,807,560
Ensembl chr 8:122,789,453...122,807,560
JBrowse link
G Cpne4 copine 4 decreases expression EXP Amitriptyline results in decreased expression of CPNE4 mRNA CTD PMID:22341215 NCBI chr 8:113,105,814...113,586,429
Ensembl chr 8:113,105,814...113,586,418
JBrowse link
G Cpped1 calcineurin-like phosphoesterase domain containing 1 affects expression EXP Amitriptyline affects the expression of CPPED1 mRNA CTD PMID:18355885 NCBI chr10:3,655,038...3,774,887
Ensembl chr10:3,655,038...3,774,884
JBrowse link
G Crem cAMP responsive element modulator affects expression EXP Amitriptyline affects the expression of CREM mRNA CTD PMID:18355885 NCBI chr17:57,021,704...57,090,888
Ensembl chr17:57,031,766...57,090,888
JBrowse link
G Csrp3 cysteine and glycine rich protein 3 increases expression EXP Amitriptyline results in increased expression of CSRP3 mRNA CTD PMID:22341215 NCBI chr 1:104,147,205...104,166,389
Ensembl chr 1:104,147,206...104,166,367
JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO Amitriptyline inhibits the reaction [7-ketocholesterol affects the localization of CYBB protein]; Amitriptyline inhibits the reaction [7-ketocholesterol analog affects the localization of CYBB protein] CTD PMID:28633109 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing
multiple interactions
ISO Amitriptyline results in increased metabolism of CYP1A2 protein; CYP1A2 protein results in increased metabolism of Amitriptyline
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Amitriptyline
CTD PMID:18359012, PMID:23397584, PMID:27320963 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 affects expression EXP Amitriptyline affects the expression of CYP2A1 mRNA CTD PMID:18355885 NCBI chr 1:83,711,223...83,725,222
Ensembl chr 1:83,653,234...83,766,484
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP Amitriptyline results in increased expression of CYP2B1 mRNA CTD PMID:10945841 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b15 cytochrome P450, family 2, subfamily b, polypeptide 15 affects expression EXP Amitriptyline affects the expression of CYP2B15 mRNA CTD PMID:18355885 NCBI chr 1:251,325,923...251,338,404
Ensembl chr 1:251,325,923...251,338,358
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP Amitriptyline results in increased expression of CYP2B2 mRNA CTD PMID:10945841 NCBI chr 1:83,103,925...83,119,578
Ensembl chr 1:83,103,925...83,119,193
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases metabolic processing ISO CYP2B6 protein results in increased metabolism of Amitriptyline CTD PMID:27320963 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions
increases metabolic processing
ISO [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Amitriptyline
CYP2C19 protein results in increased metabolism of Amitriptyline
CTD PMID:23397584, PMID:27320963 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity
multiple interactions
increases metabolic processing
ISO Amitriptyline results in decreased activity of CYP2D6 protein
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Amitriptyline
Amitriptyline results in increased metabolism of CYP2D6 protein; CYP2D6 protein results in increased metabolism of Amitriptyline
CTD PMID:16044105, PMID:18359012, PMID:18359183, PMID:23397584, PMID:27320963 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression
affects expression
EXP Amitriptyline results in increased expression of CYP3A23-3A1 mRNA
Amitriptyline affects the expression of CYP3A23-3A1 mRNA
CTD PMID:10945841, PMID:18355885 NCBI chr12:11,053,888...11,082,742
Ensembl chr12:11,655,402...11,733,136
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases metabolic processing ISO Amitriptyline results in increased metabolism of CYP3A5 protein CTD PMID:18359012 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Cyp4f1 cytochrome P450, family 4, subfamily f, polypeptide 1 affects expression EXP Amitriptyline affects the expression of CYP4F2 mRNA CTD PMID:18355885 NCBI chr 7:15,179,472...15,191,113
Ensembl chr 7:15,179,467...15,190,796
JBrowse link
G Dcaf8 DDB1 and CUL4 associated factor 8 affects expression EXP Amitriptyline affects the expression of DCAF8 mRNA CTD PMID:18355885 NCBI chr13:90,532,153...90,587,542
Ensembl chr13:90,532,326...90,591,796
JBrowse link
G Depp1 DEPP1, autophagy regulator increases expression ISO Amitriptyline results in increased expression of DEPP1 mRNA CTD PMID:15342952, PMID:17175557, PMID:17567588 NCBI chr 4:148,780,330...148,784,566
Ensembl chr 4:148,782,479...148,784,562
JBrowse link
G Des desmin multiple interactions ISO Amitriptyline inhibits the reaction [Homocysteine results in increased expression of DES protein] CTD PMID:23024785 NCBI chr 9:82,556,574...82,564,288
Ensembl chr 9:82,556,573...82,564,294
JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases activity EXP Amitriptyline results in decreased activity of DNMT1 protein CTD PMID:19924110 NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
JBrowse link
G Drd1 dopamine receptor D1 increases expression EXP Amitriptyline results in increased expression of DRD1 mRNA CTD PMID:16499906 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
JBrowse link
G Drd3 dopamine receptor D3 increases expression EXP Amitriptyline results in increased expression of DRD3 mRNA CTD PMID:21820738 NCBI chr11:61,819,102...61,883,223
Ensembl chr11:61,822,077...61,874,327
JBrowse link
G Ecel1 endothelin converting enzyme-like 1 increases expression EXP Amitriptyline results in increased expression of ECEL1 mRNA CTD PMID:22341215 NCBI chr 9:94,238,568...94,252,484
Ensembl chr 9:94,239,006...94,250,809
JBrowse link
G Eif4b eukaryotic translation initiation factor 4B affects expression EXP Amitriptyline affects the expression of EIF4B mRNA CTD PMID:18355885 NCBI chr 7:143,679,656...143,701,452
Ensembl chr 7:143,679,617...143,701,452
JBrowse link
G Ephx1 epoxide hydrolase 1 affects expression EXP Amitriptyline affects the expression of EPHX1 mRNA CTD PMID:18355885 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G Erp29 endoplasmic reticulum protein 29 affects expression EXP Amitriptyline affects the expression of ERP29 mRNA CTD PMID:18355885 NCBI chr12:40,619,377...40,625,884
Ensembl chr12:40,619,377...40,625,883
JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO Amitriptyline results in increased expression of FABP1 mRNA CTD PMID:15342952, PMID:17175557, PMID:17567588 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954
JBrowse link
G Flrt3 fibronectin leucine rich transmembrane protein 3 increases expression EXP Amitriptyline results in increased expression of FLRT3 mRNA CTD PMID:22341215 NCBI chr 3:134,684,446...134,696,586
Ensembl chr 3:134,683,065...134,696,654
JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 increases metabolic processing ISO FMO3 protein results in increased metabolism of Amitriptyline CTD PMID:27320963 NCBI chr13:80,837,418...80,856,214
Ensembl chr13:80,837,420...80,862,963
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 increases expression
decreases expression
EXP Amitriptyline results in increased expression of GABRA1 mRNA
Amitriptyline results in decreased expression of GABRA1 mRNA
CTD PMID:21820738, PMID:22341215 NCBI chr10:27,310,718...27,371,802
Ensembl chr10:27,310,725...27,366,665
JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 increases expression EXP Amitriptyline results in increased expression of GABRA2 mRNA CTD PMID:21820738 NCBI chr14:39,662,411...39,801,082
Ensembl chr14:39,661,968...39,798,302
JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 increases expression EXP Amitriptyline results in increased expression of GABRA4 mRNA CTD PMID:21820738 NCBI chr14:39,154,072...39,230,994
Ensembl chr14:39,154,529...39,231,695
JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 increases expression EXP Amitriptyline results in increased expression of GABRB3 mRNA CTD PMID:21820738 NCBI chr 1:113,034,251...113,265,364
Ensembl chr 1:112,976,770...113,265,364
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression EXP Amitriptyline results in increased expression of GADD45A mRNA CTD PMID:22341215 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gal galanin and GMAP prepropeptide increases expression EXP Amitriptyline results in increased expression of GAL mRNA CTD PMID:22341215 NCBI chr 1:218,653,059...218,657,922
Ensembl chr 1:218,652,917...218,657,925
JBrowse link
G Gckr glucokinase regulator affects expression EXP Amitriptyline affects the expression of GCKR mRNA CTD PMID:18355885 NCBI chr 6:26,355,296...26,385,761
Ensembl chr 6:26,355,296...26,385,761
JBrowse link
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 increases expression ISO Amitriptyline results in increased expression of GDPD3 mRNA CTD PMID:15342952, PMID:17175557, PMID:17567588 NCBI chr 1:198,199,032...198,209,178
Ensembl chr 1:198,199,622...198,209,150
JBrowse link
G Gfap glial fibrillary acidic protein increases expression EXP Amitriptyline results in increased expression of GFAP mRNA CTD PMID:22954530 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Gls2 glutaminase 2 affects expression EXP Amitriptyline affects the expression of GLS2 mRNA CTD PMID:18355885 NCBI chr 7:2,605,679...2,621,853
Ensembl chr 7:2,605,719...2,621,852
JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 affects expression EXP Amitriptyline affects the expression of GOT2 mRNA CTD PMID:18355885 NCBI chr19:9,587,637...9,613,323
Ensembl chr19:9,587,653...9,613,340
JBrowse link
G Grb14 growth factor receptor bound protein 14 affects expression EXP Amitriptyline affects the expression of GRB14 mRNA CTD PMID:18355885 NCBI chr 3:50,937,403...51,054,447
Ensembl chr 3:50,937,669...51,054,378
JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 decreases expression EXP Amitriptyline results in decreased expression of GRIK1 mRNA CTD PMID:22341215 NCBI chr11:27,811,954...28,213,940
Ensembl chr11:27,811,957...27,971,359
JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases activity ISO Amitriptyline results in decreased activity of GSTP1 protein CTD PMID:15094841 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Hal histidine ammonia lyase affects expression EXP Amitriptyline affects the expression of HAL mRNA CTD PMID:18355885 NCBI chr 7:34,326,087...34,356,413
Ensembl chr 7:34,326,087...34,356,413
JBrowse link
G Hmgb2 high mobility group box 2 affects expression EXP Amitriptyline affects the expression of HMGB2 mRNA CTD PMID:18355885 NCBI chr16:36,077,615...36,080,191
Ensembl chr16:36,077,617...36,080,191
Ensembl chr11:36,077,617...36,080,191
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO Amitriptyline results in increased expression of HMGCS1 mRNA CTD PMID:16324787 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055
JBrowse link
G Hoxd1 homeo box D1 decreases expression EXP Amitriptyline results in decreased expression of HOXD1 mRNA CTD PMID:22341215 NCBI chr 3:61,685,619...61,687,758
Ensembl chr 3:61,685,619...61,687,758
JBrowse link
G Hpn hepsin increases expression ISO Amitriptyline results in increased expression of HPN mRNA CTD PMID:15342952, PMID:17175557, PMID:17567588 NCBI chr 1:89,534,112...89,549,575
Ensembl chr 1:89,534,106...89,543,967
JBrowse link
G Hpse heparanase decreases expression EXP Amitriptyline results in decreased expression of HPSE mRNA CTD PMID:22341215 NCBI chr14:10,534,358...10,576,686
Ensembl chr14:10,534,423...10,575,224
JBrowse link
G Hs3st2 heparan sulfate-glucosamine 3-sulfotransferase 2 decreases expression EXP Amitriptyline results in decreased expression of HS3ST2 mRNA CTD PMID:22341215 NCBI chr 1:191,344,979...191,474,143
Ensembl chr 1:191,344,979...191,474,142
JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A increases expression EXP Amitriptyline results in increased expression of HTR1A protein CTD PMID:1589591 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896
JBrowse link
G Htr1d 5-hydroxytryptamine receptor 1D decreases expression EXP Amitriptyline results in decreased expression of HTR1D mRNA CTD PMID:22341215 NCBI chr 5:154,780,958...154,801,505
Ensembl chr 5:154,800,226...154,801,350
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C affects binding ISO Amitriptyline binds to HTR2C protein CTD PMID:18083778 NCBI chr  X:118,084,520...118,318,040
Ensembl chr  X:118,084,890...118,318,039
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Amitriptyline inhibits the reaction [7-ketocholesterol results in increased expression of IL1B protein]; Amitriptyline inhibits the reaction [Cholesterol analog results in increased expression of IL1B protein] CTD PMID:28633109 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il33 interleukin 33 affects expression EXP Amitriptyline affects the expression of IL33 mRNA CTD PMID:18355885 NCBI chr 1:248,112,611...248,147,030
Ensembl chr 1:248,132,090...248,147,029
JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Amitriptyline results in increased expression of INHBE mRNA CTD PMID:15342952, PMID:17175557, PMID:17567588 NCBI chr 7:70,641,423...70,642,848
Ensembl chr 7:70,640,075...70,643,169
JBrowse link
G Itgb6 integrin subunit beta 6 decreases expression EXP Amitriptyline results in decreased expression of ITGB6 mRNA CTD PMID:22341215 NCBI chr 3:46,652,624...46,775,362
Ensembl chr 3:46,652,623...46,726,958
JBrowse link
G Kcna4 potassium voltage-gated channel subfamily A member 4 decreases expression EXP Amitriptyline results in decreased expression of KCNA4 mRNA CTD PMID:22341215 NCBI chr 3:98,293,295...98,300,763
Ensembl chr 3:98,297,554...98,300,680
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions ISO Amitriptyline inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:19583963, PMID:21158687 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Kcnn2 potassium calcium-activated channel subfamily N member 2 decreases activity EXP Amitriptyline results in decreased activity of KCNN2 protein CTD PMID:10915830 NCBI chr18:39,331,894...39,479,574
Ensembl chr18:39,335,377...39,479,257
JBrowse link
G Kcns1 potassium voltage-gated channel, modifier subfamily S, member 1 decreases expression EXP Amitriptyline results in decreased expression of KCNS1 mRNA CTD PMID:22341215 NCBI chr 3:160,554,423...160,561,820
Ensembl chr 3:160,554,425...160,561,741
JBrowse link
G Kcns3 potassium voltage-gated channel, modifier subfamily S, member 3 decreases expression EXP Amitriptyline results in decreased expression of KCNS3 mRNA CTD PMID:22341215 NCBI chr 6:36,764,040...36,819,810
Ensembl chr 6:36,764,044...36,819,821
JBrowse link
G Lox lysyl oxidase affects expression EXP Amitriptyline affects the expression of LOX mRNA CTD PMID:18355885 NCBI chr18:47,500,320...47,577,819
Ensembl chr18:47,500,330...47,577,819
JBrowse link
G Lss lanosterol synthase increases expression ISO Amitriptyline results in increased expression of LSS mRNA CTD PMID:15342952, PMID:17175557, PMID:17567588 NCBI chr20:12,844,522...12,870,474
Ensembl chr20:12,842,884...12,870,497
JBrowse link
G Macroh2a1 macroH2A.1 histone affects expression EXP Amitriptyline affects the expression of MACROH2A1 mRNA CTD PMID:18355885 NCBI chr17:9,282,109...9,344,698
Ensembl chr17:9,282,675...9,344,678
JBrowse link
G Manba mannosidase beta affects expression EXP Amitriptyline affects the expression of MANBA mRNA CTD PMID:18355885 NCBI chr 2:240,668,213...240,760,264
Ensembl chr 2:240,668,195...240,760,261
JBrowse link
G Maoa monoamine oxidase A affects expression EXP Amitriptyline affects the expression of MAOA mRNA CTD PMID:21820738 NCBI chr  X:6,554,698...6,620,722
Ensembl chr  X:6,554,698...6,620,722
JBrowse link
G Mlx MAX dimerization protein MLX affects expression EXP Amitriptyline affects the expression of MLX mRNA CTD PMID:18355885 NCBI chr10:88,997,011...89,002,154
Ensembl chr10:88,997,399...89,002,152
JBrowse link
G Mmp16 matrix metallopeptidase 16 increases expression EXP Amitriptyline results in increased expression of MMP16 mRNA CTD PMID:22341215 NCBI chr 5:31,568,344...31,818,368
Ensembl chr 5:31,568,419...31,810,484
JBrowse link
G Mrps18b mitochondrial ribosomal protein S18B affects expression EXP Amitriptyline affects the expression of MRPS18B mRNA CTD PMID:18355885 NCBI chr20:3,344,870...3,350,929
Ensembl chr20:3,344,870...3,350,927
JBrowse link
G Msmo1 methylsterol monooxygenase 1 affects expression EXP Amitriptyline affects the expression of MSMO1 mRNA CTD PMID:18355885 NCBI chr16:26,859,441...26,875,880
Ensembl chr16:26,859,397...26,875,973
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO Amitriptyline inhibits the reaction [7-ketocholesterol affects the localization of NLRP3 protein]; Amitriptyline inhibits the reaction [Cholesterol analog affects the localization of NLRP3 protein] CTD PMID:28633109 NCBI chr10:45,884,324...45,918,290
Ensembl chr10:45,893,018...45,918,254
JBrowse link
G Nmb neuromedin B decreases expression EXP Amitriptyline results in decreased expression of NMB mRNA CTD PMID:22341215 NCBI chr 1:142,721,263...142,724,646
Ensembl chr 1:142,721,002...142,724,511
JBrowse link
G Nmur1 neuromedin U receptor 1 decreases expression EXP Amitriptyline results in decreased expression of NMUR1 mRNA CTD PMID:21820738 NCBI chr 9:93,402,871...93,407,264
Ensembl chr 9:93,403,314...93,404,883
JBrowse link
G Nog noggin decreases expression EXP Amitriptyline results in decreased expression of NOG mRNA CTD PMID:22341215 NCBI chr10:76,811,759...76,813,386
Ensembl chr10:76,811,759...76,813,386
JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin multiple interactions ISO Amitriptyline inhibits the reaction [Homocysteine results in decreased expression of NPHS2 protein] CTD PMID:23024785 NCBI chr13:73,929,136...73,941,522
Ensembl chr13:73,929,136...73,941,522
JBrowse link
G Npy neuropeptide Y increases expression EXP Amitriptyline results in increased expression of NPY mRNA CTD PMID:22341215 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097
JBrowse link
G Npy5r neuropeptide Y receptor Y5 increases expression EXP Amitriptyline results in increased expression of NPY5R mRNA CTD PMID:21820738 NCBI chr16:24,796,685...24,805,730
Ensembl chr16:24,797,124...24,805,079
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Amitriptyline results in increased expression of NR0B2 mRNA CTD PMID:15342952, PMID:17175557 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 affects response to substance ISO NR3C1 protein affects the susceptibility to Amitriptyline CTD PMID:11226678 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 increases expression EXP Amitriptyline results in increased expression of NR3C2 mRNA CTD PMID:12393271 NCBI chr19:34,408,275...34,761,003
Ensembl chr19:34,448,289...34,752,695
JBrowse link
G Nrep neuronal regeneration related protein affects expression EXP Amitriptyline affects the expression of NREP mRNA CTD PMID:18355885 NCBI chr18:26,183,753...26,212,796
Ensembl chr18:26,185,259...26,211,445
JBrowse link
G Ntng1 netrin G1 decreases expression EXP Amitriptyline results in decreased expression of NTNG1 mRNA CTD PMID:22341215 NCBI chr 2:212,695,464...213,073,046
Ensembl chr 2:212,696,624...212,852,870
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Amitriptyline results in increased expression of NUPR1 mRNA CTD PMID:15342952, PMID:17175557, PMID:17567588 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524
JBrowse link
G Oaf out at first homolog affects expression EXP Amitriptyline affects the expression of OAF mRNA CTD PMID:18355885 NCBI chr 8:47,511,718...47,529,689
Ensembl chr 8:47,511,719...47,529,689
JBrowse link
G Patj PATJ, crumbs cell polarity complex component decreases expression EXP Amitriptyline results in decreased expression of PATJ mRNA CTD PMID:22341215 NCBI chr 5:117,038,548...117,340,308
Ensembl chr 5:117,052,260...117,340,336
JBrowse link
G Pc pyruvate carboxylase affects expression EXP Amitriptyline affects the expression of PC mRNA CTD PMID:18355885 NCBI chr 1:219,759,157...219,859,854
Ensembl chr 1:219,759,183...219,859,848
JBrowse link
G Pecr peroxisomal trans-2-enoyl-CoA reductase affects expression EXP Amitriptyline affects the expression of PECR mRNA CTD PMID:18355885 NCBI chr 9:79,601,937...79,630,547
Ensembl chr 9:79,601,901...79,630,536
JBrowse link
G Phyh phytanoyl-CoA 2-hydroxylase increases expression ISO Amitriptyline results in increased expression of PHYH mRNA CTD PMID:15342952 NCBI chr17:77,287,580...77,304,482
Ensembl chr17:77,287,188...77,304,530
JBrowse link
G Plcd4 phospholipase C, delta 4 decreases expression EXP Amitriptyline results in decreased expression of PLCD4 mRNA CTD PMID:22341215 NCBI chr 9:81,816,395...81,844,364
Ensembl chr 9:81,816,872...81,844,364
JBrowse link
G Plpp4 phospholipid phosphatase 4 decreases expression EXP Amitriptyline results in decreased expression of PLPP4 mRNA CTD PMID:22341215 NCBI chr 1:202,432,366...202,560,628
Ensembl chr 1:202,432,366...202,560,628
JBrowse link
G Por cytochrome p450 oxidoreductase affects expression EXP Amitriptyline affects the expression of POR mRNA CTD PMID:18355885 NCBI chr12:23,998,411...24,017,063
Ensembl chr12:23,998,411...24,046,814
JBrowse link
G Prokr1 prokineticin receptor 1 decreases expression EXP Amitriptyline results in decreased expression of PROKR1 mRNA CTD PMID:21820738 NCBI chr 4:119,375,790...119,386,551
Ensembl chr 4:119,375,778...119,386,590
JBrowse link
G Pycard PYD and CARD domain containing multiple interactions ISO Amitriptyline inhibits the reaction [7-ketocholesterol affects the localization of PYCARD protein]; Amitriptyline inhibits the reaction [Cholesterol analog affects the localization of PYCARD protein] CTD PMID:28633109 NCBI chr 1:199,438,029...199,439,062
Ensembl chr 1:199,437,832...199,439,210
JBrowse link
G Rasd1 ras related dexamethasone induced 1 increases expression EXP Amitriptyline results in increased expression of RASD1 mRNA CTD PMID:22341215 NCBI chr10:46,330,361...46,339,326
Ensembl chr10:46,330,368...46,332,172
JBrowse link
G Rbl2 RB transcriptional corepressor like 2 affects expression EXP Amitriptyline affects the expression of RBL2 mRNA CTD PMID:18355885 NCBI chr19:17,300,088...17,346,865
Ensembl chr19:17,300,089...17,346,808
JBrowse link
G Reg3b regenerating family member 3 beta increases expression EXP Amitriptyline results in increased expression of REG3B mRNA CTD PMID:22341215 NCBI chr 4:109,467,272...109,470,510
Ensembl chr 4:109,467,272...109,470,510
JBrowse link
G Rnf112 ring finger protein 112 decreases expression EXP Amitriptyline results in decreased expression of RNF112 mRNA CTD PMID:22341215 NCBI chr10:47,719,034...47,726,050
Ensembl chr10:47,719,014...47,725,172
JBrowse link
G RT1-Da RT1 class II, locus Da increases expression EXP Amitriptyline results in increased expression of RT1-DA mRNA CTD PMID:22341215 NCBI chr20:4,127,644...4,132,616
Ensembl chr20:4,127,644...4,132,616
JBrowse link
G RT1-Db1 RT1 class II, locus Db1 increases expression EXP Amitriptyline results in increased expression of RT1-DB1 mRNA CTD PMID:22341215 NCBI chr20:4,087,621...4,097,190
Ensembl chr20:4,087,618...4,097,190
JBrowse link
G RT1-S3 RT1 class Ib, locus S3 affects expression EXP Amitriptyline affects the expression of RT1-S3 mRNA CTD PMID:18355885 NCBI chr20:3,176,124...3,180,825
Ensembl chr20:3,176,107...3,179,818
JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO Amitriptyline results in increased expression of SCD mRNA CTD PMID:16324787 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Scn11a sodium voltage-gated channel alpha subunit 11 decreases expression EXP Amitriptyline results in decreased expression of SCN11A mRNA CTD PMID:22341215 NCBI chr 8:128,450,793...128,527,510
Ensembl chr 8:128,450,801...128,521,109
JBrowse link
G Sema6a semaphorin 6A increases expression EXP Amitriptyline results in increased expression of SEMA6A mRNA CTD PMID:22341215 NCBI chr18:41,330,519...41,451,813
Ensembl chr18:41,333,551...41,389,510
JBrowse link
G Serpina3m serpin family A member 3M increases expression ISO Amitriptyline results in increased expression of SERPINA3 mRNA CTD PMID:15342952, PMID:17175557, PMID:17567588 NCBI chr 6:127,808,785...127,816,067
Ensembl chr 6:127,808,785...127,816,055
JBrowse link
G Sh3gl3 SH3 domain containing GRB2 like 3, endophilin A3 affects expression EXP Amitriptyline affects the expression of SH3GL3 mRNA CTD PMID:18355885 NCBI chr 1:144,069,641...144,200,402
Ensembl chr 1:144,069,638...144,200,397
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions
decreases activity
ISO Amitriptyline inhibits the reaction [SLC22A1 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]
Amitriptyline results in decreased activity of SLC22A1 protein
CTD PMID:30189235, PMID:31364238 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions
decreases activity
ISO Amitriptyline inhibits the reaction [SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]; Amitriptyline inhibits the reaction [SLC22A2 protein results in increased import of Tetraethylammonium]; Amitriptyline inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Amitriptyline inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]
Amitriptyline results in decreased activity of SLC22A2 protein
CTD PMID:21599003, PMID:23770354, PMID:28629854, PMID:30189235, PMID:31364238 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO Amitriptyline inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:21561794 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression ISO Amitriptyline results in decreased expression of SLC2A3 mRNA CTD PMID:15342952, PMID:17175557, PMID:17567588 NCBI chr 4:155,549,991...155,626,018
Ensembl chr 4:155,408,233...155,631,856
JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Amitriptyline inhibits the reaction [SLC47A2 protein results in increased import of Tetraethylammonium] CTD PMID:28629854 NCBI chr10:47,587,909...47,631,373
Ensembl chr10:47,588,497...47,630,799
JBrowse link
G Slc6a6 solute carrier family 6 member 6 affects expression EXP Amitriptyline affects the expression of SLC6A6 mRNA CTD PMID:18355885 NCBI chr 4:123,638,619...123,713,469
Ensembl chr 4:123,642,210...123,713,464
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects expression EXP Amitriptyline affects the expression of SLCO1A4 mRNA CTD PMID:18355885 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163
JBrowse link
G Smagp small cell adhesion glycoprotein increases expression EXP Amitriptyline results in increased expression of SMAGP mRNA CTD PMID:22341215 NCBI chr 7:142,244,295...142,260,896
Ensembl chr 7:142,244,295...142,260,896
JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 multiple interactions
increases response to substance
decreases activity
ISO [Amitriptyline results in decreased expression of and results in decreased activity of SMPD1 protein] which results in decreased abundance of Ceramides; Amitriptyline results in decreased expression of and results in decreased activity of SMPD1 protein
SMPD1 protein results in increased susceptibility to Amitriptyline
Amitriptyline results in decreased activity of SMPD1 protein
CTD PMID:23770692 NCBI chr 1:170,383,682...170,387,525
Ensembl chr 1:170,383,682...170,387,524
JBrowse link
G Sod1 superoxide dismutase 1 increases expression EXP Amitriptyline results in increased expression of SOD1 mRNA CTD PMID:10721683 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sorl1 sortilin related receptor 1 decreases expression EXP Amitriptyline results in decreased expression of SORL1 mRNA CTD PMID:22341215 NCBI chr 8:46,228,077...46,287,171 JBrowse link
G Sox11 SRY-box transcription factor 11 increases expression EXP Amitriptyline results in increased expression of SOX11 mRNA CTD PMID:22341215 NCBI chr 6:46,629,967...46,631,988
Ensembl chr 6:46,629,974...46,631,983
JBrowse link
G Sprr1a small proline-rich protein 1A increases expression EXP Amitriptyline results in increased expression of SPRR1A mRNA CTD PMID:22341215 NCBI chr 2:192,669,143...192,671,059
Ensembl chr 2:192,669,143...192,671,059
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO Amitriptyline results in increased cleavage of and results in increased activity of SREBF1 protein CTD PMID:16324787 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions ISO Amitriptyline results in increased cleavage of and results in increased activity of SREBF2 protein CTD PMID:16324787 NCBI chr 7:123,381,082...123,438,605
Ensembl chr 7:123,381,077...123,438,603
JBrowse link
G Sstr1 somatostatin receptor 1 decreases expression EXP Amitriptyline results in decreased expression of SSTR1 mRNA CTD PMID:21820738 NCBI chr 6:79,252,914...79,258,611
Ensembl chr 6:79,254,339...79,258,611
JBrowse link
G St13 ST13, Hsp70 interacting protein affects expression EXP Amitriptyline affects the expression of ST13 mRNA CTD PMID:18355885 NCBI chr 7:122,585,770...122,635,731
Ensembl chr 7:122,585,771...122,635,731
JBrowse link
G Stac2 SH3 and cysteine rich domain 2 increases expression EXP Amitriptyline results in increased expression of STAC2 mRNA CTD PMID:22341215 NCBI chr10:85,988,367...86,004,209
Ensembl chr10:85,988,367...86,004,209
JBrowse link
G Stbd1 starch binding domain 1 affects expression EXP Amitriptyline affects the expression of STBD1 mRNA CTD PMID:18355885 NCBI chr14:16,976,355...16,979,760
Ensembl chr14:16,976,356...16,979,760
JBrowse link
G Stmn1 stathmin 1 affects expression EXP Amitriptyline affects the expression of STMN1 mRNA CTD PMID:18355885 NCBI chr 5:152,680,412...152,686,807
Ensembl chr 5:152,680,407...152,686,806
JBrowse link
G Stmn4 stathmin 4 increases expression EXP Amitriptyline results in increased expression of STMN4 mRNA CTD PMID:22341215 NCBI chr15:43,007,901...43,025,852
Ensembl chr15:43,007,908...43,025,852
JBrowse link
G Tagln transgelin decreases expression ISO Amitriptyline results in decreased expression of TAGLN mRNA CTD PMID:15342952, PMID:17175557, PMID:17567588 NCBI chr 8:50,222,895...50,228,369
Ensembl chr 8:50,222,896...50,231,357
JBrowse link
G Tex261 testis expressed 261 affects expression EXP Amitriptyline affects the expression of TEX261 mRNA CTD PMID:18355885 NCBI chr 4:115,446,830...115,454,035
Ensembl chr 4:115,448,708...115,453,659
JBrowse link
G Tgm1 transglutaminase 1 increases expression EXP Amitriptyline results in increased expression of TGM1 mRNA CTD PMID:22341215 NCBI chr15:34,378,136...34,393,150
Ensembl chr15:34,378,148...34,392,066
JBrowse link
G Timm10b translocase of inner mitochondrial membrane 10B affects expression EXP Amitriptyline affects the expression of TIMM10B mRNA CTD PMID:18355885 NCBI chr 1:170,471,265...170,474,111
Ensembl chr 1:170,471,238...170,474,113
JBrowse link
G Trh thyrotropin releasing hormone multiple interactions ISO Amitriptyline inhibits the reaction [TRH protein results in decreased expression of TSHB protein] CTD PMID:6455462 NCBI chr 4:124,110,716...124,113,242
Ensembl chr 4:124,110,716...124,113,242
JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions ISO Amitriptyline inhibits the reaction [TRH protein results in decreased expression of TSHB protein] CTD PMID:6455462 NCBI chr 2:205,207,799...205,215,199
Ensembl chr 2:205,207,799...205,212,681
JBrowse link
G Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1 affects expression EXP Amitriptyline affects the expression of UBA52 mRNA CTD PMID:18355885 NCBI chr16:20,668,925...20,671,127
Ensembl chr16:20,668,971...20,671,127
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 affects expression EXP Amitriptyline affects the expression of UGT1A1 mRNA CTD PMID:18355885 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2a1 UDP glucuronosyltransferase family 2 member A1 affects expression EXP Amitriptyline affects the expression of UGT2A1 mRNA CTD PMID:18355885 NCBI chr14:22,192,970...22,217,094 JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 affects expression EXP Amitriptyline affects the expression of UGT2B1 mRNA CTD PMID:18355885 NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Amitriptyline inhibits the reaction [Homocysteine results in decreased secretion of VEGFA protein] CTD PMID:23024785 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Amitriptyline results in increased expression of WIPI1 mRNA CTD PMID:15342952, PMID:17175557 NCBI chr10:97,859,730...97,896,949
Ensembl chr10:97,859,727...97,896,525
JBrowse link
azatadine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hrh1 histamine receptor H 1 multiple interactions ISO azatadine binds to and results in decreased activity of HRH1 protein CTD PMID:2864258 NCBI chr 4:146,374,596...146,458,148
Ensembl chr 4:146,455,332...146,457,074
JBrowse link
benzphetamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases metabolic processing ISO CYP2B6 protein results in increased metabolism of Benzphetamine CTD PMID:12464242, PMID:15769884 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
bepridil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO Bepridil inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] CTD PMID:11895100 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO Bepridil results in increased expression of ATF4 protein CTD PMID:21292685 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Bepridil results in increased expression of DDIT3 protein CTD PMID:21292685 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases phosphorylation ISO Bepridil results in increased phosphorylation of EIF2A protein CTD PMID:21292685 NCBI chr 2:148,722,343...148,755,781
Ensembl chr 2:148,722,231...148,755,520
JBrowse link
G Kcna5 potassium voltage-gated channel subfamily A member 5 decreases activity ISO Bepridil results in decreased activity of KCNA5 protein CTD PMID:11711026 NCBI chr 4:159,077,195...159,079,003
Ensembl chr 4:159,077,195...159,079,003
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity
ISO Bepridil binds to and results in decreased activity of KCNH2 protein; Bepridil inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Bepridil results in decreased activity of KCNH2 protein
CTD PMID:15272206, PMID:15671647, PMID:21158687, PMID:24052561 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Slc8a1 solute carrier family 8 member A1 multiple interactions ISO Bepridil inhibits the reaction [SLC8A1 protein results in increased susceptibility to Chlorodiphenyl (54% Chlorine)] CTD PMID:16009740 NCBI chr 6:4,244,076...4,564,262
Ensembl chr 6:4,258,991...4,520,604
JBrowse link
G Tnfsf10 TNF superfamily member 10 increases response to substance ISO Bepridil results in increased susceptibility to TNFSF10 protein CTD PMID:21292685 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
JBrowse link
butenafine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA] CTD PMID:23688403 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [Biological Products results in increased expression of CXCL10 protein]]; butenafine inhibits the reaction [Biological Products results in increased expression of CXCL10 mRNA]; butenafine inhibits the reaction [Biological Products results in increased expression of CXCL10 protein] CTD PMID:24471457 NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
JBrowse link
G Il4 interleukin 4 multiple interactions ISO 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; butenafine promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone] CTD PMID:23688403 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein] CTD PMID:23688403 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO butenafine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [Biological Products results in increased activity of STAT1 protein]]; butenafine inhibits the reaction [Biological Products results in increased phosphorylation of and results in increased activity of STAT1 protein] CTD PMID:24471457 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Tslp thymic stromal lymphopoietin multiple interactions ISO 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein] CTD PMID:23688403 NCBI chr18:25,613,601...25,618,066
Ensembl chr18:25,613,831...25,617,361
JBrowse link
chlorpromazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases expression
ISO
EXP
[Chlorpromazine co-treated with Cholic Acids] affects the expression of ABCB11 mRNA
Chlorpromazine results in decreased expression of ABCB11 mRNA
CTD PMID:27344345, PMID:27765674, PMID:28391356 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
decreases activity
ISO Chlorpromazine analog results in increased expression of ABCB1 mRNA
Chlorpromazine results in decreased activity of ABCB1 protein
CTD PMID:15924885, PMID:16810505 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B affects activity EXP Chlorpromazine affects the activity of ABCB1B protein CTD PMID:12626638 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 multiple interactions ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of ABCB4 mRNA CTD PMID:27344345 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb6 ATP binding cassette subfamily B member 6 decreases expression EXP Chlorpromazine results in decreased expression of ABCB6 mRNA CTD PMID:25596134 NCBI chr 9:82,373,950...82,382,228
Ensembl chr 9:82,373,946...82,382,272
JBrowse link
G Abcb9 ATP binding cassette subfamily B member 9 increases expression EXP Chlorpromazine results in increased expression of ABCB9 mRNA CTD PMID:25596134 NCBI chr12:37,923,974...37,956,678
Ensembl chr12:37,923,528...37,958,363
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression EXP Chlorpromazine results in increased expression of ABCC2 mRNA CTD PMID:27765674 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression
decreases expression
ISO
EXP
Chlorpromazine analog results in increased expression of ABCC3 mRNA
Chlorpromazine results in decreased expression of ABCC3 mRNA
CTD PMID:15924885, PMID:25596134 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO Chlorpromazine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone] CTD PMID:18834354 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 multiple interactions ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of ABCG8 mRNA CTD PMID:27344345 NCBI chr 6:7,961,413...7,980,708
Ensembl chr 6:7,961,413...7,980,708
JBrowse link
G Acaca acetyl-CoA carboxylase alpha decreases phosphorylation EXP Chlorpromazine results in decreased phosphorylation of ACACA protein CTD PMID:17512020 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Ache acetylcholinesterase decreases activity
increases activity
multiple interactions
ISO Chlorpromazine results in decreased activity of ACHE protein
Chlorpromazine results in increased activity of ACHE protein
Dichlorvos promotes the reaction [Chlorpromazine results in decreased activity of ACHE protein]
CTD PMID:4859365, PMID:29614332 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions ISO Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA] CTD PMID:21869564 NCBI chr 8:23,142,733...23,149,067
Ensembl chr 8:23,142,734...23,148,396
JBrowse link
G Adra1a adrenoceptor alpha 1A decreases activity EXP Chlorpromazine results in decreased activity of ADRA1A protein CTD PMID:23611293 NCBI chr15:43,296,997...43,398,314
Ensembl chr15:43,298,794...43,392,451
JBrowse link
G Adra1b adrenoceptor alpha 1B decreases activity EXP Chlorpromazine results in decreased activity of ADRA1B protein CTD PMID:23611293 NCBI chr10:29,392,762...29,450,644
Ensembl chr10:29,392,762...29,450,644
JBrowse link
G Afp alpha-fetoprotein decreases expression ISO Chlorpromazine analog results in decreased expression of AFP mRNA CTD PMID:15924885 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
JBrowse link
G Agrn agrin decreases expression EXP Chlorpromazine results in decreased expression of AGRN mRNA CTD PMID:25596134 NCBI chr 5:173,589,910...173,622,813
Ensembl chr 5:173,589,819...173,622,645
JBrowse link
G Ahr aryl hydrocarbon receptor affects activity EXP Chlorpromazine affects the activity of AHR protein CTD PMID:25596134 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Ak3 adenylate kinase 3 decreases expression EXP Chlorpromazine results in decreased expression of AK3 mRNA CTD PMID:25596134 NCBI chr 1:247,144,486...247,169,690
Ensembl chr 1:247,144,491...247,169,693
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation EXP Chlorpromazine results in decreased phosphorylation of AKT1 protein CTD PMID:17512020 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 multiple interactions ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of ALDH1A1 mRNA CTD PMID:27344345 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Aldoa aldolase, fructose-bisphosphate A increases expression EXP Chlorpromazine results in increased expression of ALDOA mRNA CTD PMID:25596134 NCBI chr 1:198,228,387...198,233,988
Ensembl chr 1:198,228,387...198,233,588
JBrowse link
G Alpp alkaline phosphatase, placental multiple interactions ISO Chlorpromazine inhibits the reaction [Colforsin results in increased expression of ALPP mRNA]; Chlorpromazine inhibits the reaction [Isoproterenol results in increased expression of ALPP mRNA] CTD PMID:16036225 NCBI chr 9:94,189,961...94,193,054
Ensembl chr 9:94,190,067...94,192,813
JBrowse link
G Ap1s1 adaptor related protein complex 1 subunit sigma 1 decreases expression ISO Chlorpromazine results in decreased expression of AP1S1 mRNA CTD PMID:17175557 NCBI chr12:22,665,128...22,676,079
Ensembl chr12:22,665,112...22,676,075
JBrowse link
G Apoc4 apolipoprotein C4 multiple interactions ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of APOC4 mRNA CTD PMID:27344345 NCBI chr 1:80,595,339...80,599,525
Ensembl chr 1:80,595,326...80,599,572
JBrowse link
G Apof apolipoprotein F multiple interactions ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of APOF mRNA CTD PMID:27344345 NCBI chr 7:2,689,501...2,690,938
Ensembl chr 7:2,689,501...2,690,936
JBrowse link
G Areg amphiregulin decreases expression ISO Chlorpromazine results in decreased expression of AREG mRNA CTD PMID:15924885, PMID:30703373 NCBI chr14:18,521,921...18,531,179
Ensembl chr14:18,521,930...18,531,179
JBrowse link
G Arfgef2 ADP ribosylation factor guanine nucleotide exchange factor 2 increases expression EXP Chlorpromazine results in increased expression of ARFGEF2 mRNA CTD PMID:25596134 NCBI chr 3:163,570,435...163,656,612
Ensembl chr 3:163,570,532...163,656,626
JBrowse link
G Arhgef10 Rho guanine nucleotide exchange factor 10 decreases expression EXP Chlorpromazine results in decreased expression of ARHGEF10 mRNA CTD PMID:25596134 NCBI chr16:79,725,629...79,817,065
Ensembl chr16:79,725,643...79,793,619
JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 increases expression ISO Chlorpromazine results in increased expression of ASAH1 mRNA CTD PMID:17175557 NCBI chr16:53,998,604...54,030,006
Ensembl chr16:53,998,560...54,040,836
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Chlorpromazine results in increased expression of ASNS mRNA CTD PMID:17175557 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
JBrowse link
G Atf4 activating transcription factor 4 affects activity
multiple interactions
EXP
ISO
Chlorpromazine affects the activity of ATF4 protein
[Chlorpromazine co-treated with Cholic Acids] affects the expression of ATF4 mRNA
CTD PMID:25596134, PMID:27344345 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atp6v1b2 ATPase H+ transporting V1 subunit B2 decreases expression EXP Chlorpromazine results in decreased expression of ATP6V1B2 protein CTD PMID:19441803 NCBI chr16:22,326,537...22,350,143
Ensembl chr16:22,326,529...22,350,155
JBrowse link
G Avp arginine vasopressin increases expression
multiple interactions
ISO
EXP
Chlorpromazine results in increased expression of AVP protein
Chlorpromazine inhibits the reaction [Lithium results in increased expression of AVP protein]
CTD PMID:3567260, PMID:3976404 NCBI chr 3:123,117,482...123,119,460
Ensembl chr 3:123,117,492...123,119,460
JBrowse link
G Bag4 BAG cochaperone 4 decreases expression ISO Chlorpromazine analog results in decreased expression of BAG4 mRNA CTD PMID:15924885 NCBI chr16:71,057,709...71,075,874
Ensembl chr16:71,058,022...71,075,320
JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression ISO Chlorpromazine results in increased expression of BCL2L1 mRNA CTD PMID:21683644 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bdnf brain-derived neurotrophic factor affects response to substance
affects expression
ISO
EXP
BDNF affects the susceptibility to Chlorpromazine
Chlorpromazine affects the expression of BDNF mRNA
CTD PMID:18408624, PMID:31324950 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Bhlhe40 basic helix-loop-helix family, member e40 increases expression ISO Chlorpromazine analog results in increased expression of BHLHE40 mRNA CTD PMID:15924885 NCBI chr 4:140,703,619...140,709,319
Ensembl chr 4:140,703,619...140,709,319
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 decreases expression ISO Chlorpromazine results in decreased expression of BIRC2 mRNA CTD PMID:30703373 NCBI chr 8:6,014,014...6,036,668
Ensembl chr 8:6,013,207...6,034,142
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO Chlorpromazine analog results in decreased expression of BIRC5 mRNA; Chlorpromazine results in decreased expression of BIRC5 mRNA CTD PMID:15924885, PMID:30703373 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression EXP Chlorpromazine results in increased expression of BNIP3 mRNA CTD PMID:25596134 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression ISO Chlorpromazine analog results in increased expression of BTG2 mRNA CTD PMID:15924885 NCBI chr13:50,913,185...50,916,944
Ensembl chr13:50,913,180...50,916,982
JBrowse link
G Btg3 BTG anti-proliferation factor 3 increases expression ISO Chlorpromazine analog results in increased expression of BTG3 mRNA CTD PMID:15924885 NCBI chr11:16,873,642...16,889,100
Ensembl chr11:16,873,646...16,889,201
JBrowse link
G C3 complement C3 multiple interactions ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of C3 mRNA CTD PMID:27344345 NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167
JBrowse link
G C6 complement C6 multiple interactions ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of C6 mRNA CTD PMID:27344345 NCBI chr 2:54,460,333...54,533,801
Ensembl chr 2:54,466,280...54,533,797
JBrowse link
G Calcr calcitonin receptor multiple interactions ISO Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA] CTD PMID:21869564 NCBI chr 4:28,627,439...28,702,559
Ensembl chr 4:28,627,442...28,702,559
JBrowse link
G Calr calreticulin decreases expression EXP Chlorpromazine results in decreased expression of CALR mRNA CTD PMID:18246545 NCBI chr19:25,956,771...25,961,666
Ensembl chr19:25,956,771...25,961,666
JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions ISO Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of CAR2 mRNA] CTD PMID:21869564 NCBI chr 2:88,097,740...88,112,868
Ensembl chr 2:88,097,720...88,113,029
JBrowse link
G Cat catalase multiple interactions
decreases expression
decreases activity
EXP
ISO
carvedilol inhibits the reaction [Chlorpromazine results in decreased expression of CAT protein]; zolpidem inhibits the reaction [Chlorpromazine results in decreased activity of CAT] CTD PMID:12010767, PMID:17513028, PMID:25449126 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression ISO Chlorpromazine results in decreased expression of CCN2 mRNA; Chlorpromazine results in decreased expression of CCN2 protein CTD PMID:30703373 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Ccn3 cellular communication network factor 3 affects expression EXP Chlorpromazine affects the expression of CCN3 mRNA CTD PMID:31324950 NCBI chr 7:94,375,134...94,382,154
Ensembl chr 7:94,375,020...94,383,024
JBrowse link
G Ccnb2 cyclin B2 decreases expression ISO Chlorpromazine analog results in decreased expression of CCNB2 mRNA; Chlorpromazine results in decreased expression of CCNB2 mRNA CTD PMID:15924885 NCBI chr 8:76,847,972...76,861,165 JBrowse link
G Ccnd1 cyclin D1 decreases expression EXP Chlorpromazine results in decreased expression of CCND1 mRNA CTD PMID:17202759 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO Chlorpromazine analog results in decreased expression of CCND3 mRNA CTD PMID:15924885 NCBI chr 9:15,404,816...15,410,905
Ensembl chr 9:15,404,822...15,410,943
JBrowse link
G Ccnf cyclin F decreases expression ISO Chlorpromazine analog results in decreased expression of CCNF mRNA CTD PMID:15924885 NCBI chr10:13,594,687...13,619,935
Ensembl chr10:13,594,687...13,619,935
JBrowse link
G Cd274 CD274 molecule multiple interactions ISO Chlorpromazine inhibits the reaction [platycodin D results in decreased expression of and results in increased secretion of CD274 protein] CTD PMID:31150782 NCBI chr 1:247,519,890...247,539,659
Ensembl chr 1:247,519,939...247,537,943
JBrowse link
G Cd44 CD44 molecule (Indian blood group) multiple interactions
decreases expression
ISO Chlorpromazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD44 protein]
Chlorpromazine results in decreased expression of CD44 protein
CTD PMID:9929743, PMID:30703373 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cd86 CD86 molecule increases expression ISO Chlorpromazine results in increased expression of CD86 protein CTD PMID:19665512 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Cdk5 cyclin-dependent kinase 5 decreases expression ISO Chlorpromazine analog results in decreased expression of CDK5 mRNA CTD PMID:15924885 NCBI chr 4:7,282,945...7,287,427
Ensembl chr 4:7,282,948...7,288,383
JBrowse link
G Cdk7 cyclin-dependent kinase 7 increases expression ISO Chlorpromazine analog results in increased expression of CDK7 mRNA CTD PMID:15924885 NCBI chr 2:30,710,642...30,735,522
Ensembl chr 2:30,710,643...30,735,514
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression
EXP [EGR1 binds to CDKN1A promoter] promotes the reaction [Chlorpromazine results in increased expression of CDKN1A mRNA]; EGR1 promotes the reaction [Chlorpromazine results in increased expression of CDKN1A mRNA] CTD PMID:20368687 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C decreases expression ISO Chlorpromazine analog results in decreased expression of CDKN2C mRNA CTD PMID:15924885 NCBI chr 5:129,347,731...129,352,886
Ensembl chr 5:129,347,732...129,352,886
JBrowse link
G Ces2h carboxylesterase 2H multiple interactions ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of CES2 mRNA CTD PMID:27344345 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156
JBrowse link
G Cfh complement factor H multiple interactions ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of CFH mRNA CTD PMID:27344345 NCBI chr13:56,979,155...57,080,540
Ensembl chr13:56,978,607...57,080,622
JBrowse link
G Cgref1 cell growth regulator with EF hand domain 1 decreases expression EXP Chlorpromazine results in decreased expression of CGREF1 mRNA CTD PMID:17202759 NCBI chr 6:26,797,126...26,809,132
Ensembl chr 6:26,797,126...26,809,129
JBrowse link
G Chtf18 chromosome transmission fidelity factor 18 decreases expression ISO Chlorpromazine analog results in decreased expression of CHTF18 mRNA CTD PMID:15924885 NCBI chr10:15,090,762...15,098,825
Ensembl chr10:15,090,316...15,098,791
JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 decreases expression EXP Chlorpromazine results in decreased expression of CITED2 mRNA CTD PMID:18246545 NCBI chr 1:12,823,363...12,825,806
Ensembl chr 1:12,823,363...12,825,786
JBrowse link
G Cks2 CDC28 protein kinase regulatory subunit 2 decreases expression ISO Chlorpromazine analog results in decreased expression of CKS2 mRNA CTD PMID:15924885 NCBI chr17:13,587,664...13,593,423
Ensembl chr17:13,587,665...13,593,423
JBrowse link
G Clcf1 cardiotrophin-like cytokine factor 1 increases expression ISO Chlorpromazine results in increased expression of CLCF1 mRNA CTD PMID:21683644 NCBI chr 1:219,468,866...219,472,445
Ensembl chr 1:219,468,675...219,472,654
JBrowse link
G Col18a1 collagen type XVIII alpha 1 chain multiple interactions ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of COL18A1 mRNA CTD PMID:27344345 NCBI chr20:12,225,202...12,332,858
Ensembl chr20:12,225,202...12,332,858
JBrowse link
G Col4a1 collagen type IV alpha 1 chain decreases expression EXP Chlorpromazine results in decreased expression of COL4A1 mRNA CTD PMID:25596134 NCBI chr16:83,522,162...83,632,153
Ensembl chr16:83,522,162...83,632,153
JBrowse link
G Cort cortistatin affects expression EXP Chlorpromazine affects the expression of CORT mRNA CTD PMID:31324950 NCBI chr 5:165,942,780...165,944,221 JBrowse link
G Cox8a cytochrome c oxidase subunit 8A affects expression
increases expression
EXP Chlorpromazine affects the expression of COX8A mRNA
Chlorpromazine results in increased expression of COX8A mRNA
CTD PMID:18246545 NCBI chr 1:222,466,575...222,468,896
Ensembl chr 1:222,466,575...222,468,896
JBrowse link
G Crh corticotropin releasing hormone decreases expression ISO Chlorpromazine results in decreased expression of CRH mRNA CTD PMID:16205782 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Cth cystathionine gamma-lyase decreases expression EXP Chlorpromazine results in decreased expression of CTH mRNA CTD PMID:25596134 NCBI chr 2:264,266,959...264,293,040
Ensembl chr 2:264,266,984...264,293,046
JBrowse link
G Ctsk cathepsin K multiple interactions ISO Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA] CTD PMID:21869564 NCBI chr 2:196,655,469...196,666,447
Ensembl chr 2:196,655,469...196,666,446
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases response to substance
increases expression
ISO
EXP
[Filipin co-treated with Chlorpromazine co-treated with Wortmannin] inhibits the reaction [Particulate Matter results in increased expression of CYP1A1 mRNA]; Chlorpromazine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
CYP1A1 protein results in decreased susceptibility to Chlorpromazine
Chlorpromazine results in increased expression of CYP1A1 mRNA
CTD PMID:17202759, PMID:18246545, PMID:18493746, PMID:25596134, PMID:26477383, PMID:29724254 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases response to substance
increases expression
increases oxidation
affects expression
decreases methylation
ISO
EXP
[Chlorpromazine co-treated with Cholic Acids] affects the expression of CYP1A2 mRNA; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Chlorpromazine; Chlorpromazine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]; CYP1A2 protein results in increased metabolism of and results in increased activity of Chlorpromazine
CYP1A2 protein results in decreased susceptibility to Chlorpromazine
Chlorpromazine results in increased expression of CYP1A2 mRNA
CYP1A2 protein results in increased oxidation of Chlorpromazine
Chlorpromazine affects the expression of CYP1A2 mRNA
CYP1A2 protein results in decreased methylation of Chlorpromazine
CTD PMID:18246545, PMID:18493746, PMID:19482014, PMID:20615392, PMID:23397584, PMID:25596134, PMID:26477383, PMID:27344345 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases response to substance
multiple interactions
ISO CYP1B1 protein results in decreased susceptibility to Chlorpromazine
[Filipin co-treated with Chlorpromazine co-treated with Wortmannin] inhibits the reaction [Particulate Matter results in increased expression of CYP1B1 mRNA]
CTD PMID:26477383, PMID:29724254 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions ISO NR1I3 protein affects the reaction [Chlorpromazine results in increased expression of CYP2B10 mRNA] CTD PMID:12049174 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
decreases response to substance
ISO [Chlorpromazine results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; Chlorpromazine inhibits the reaction [Androstenols inhibits the reaction [NR1I3 protein results in increased expression of CYP2B6 mRNA]]
CYP2B6 protein results in decreased susceptibility to Chlorpromazine
CTD PMID:10037683, PMID:17041008, PMID:26477383 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases expression EXP Chlorpromazine results in decreased expression of CYP2C mRNA; Chlorpromazine results in decreased expression of CYP2C11 mRNA CTD PMID:18246545 NCBI chr 1:257,676,172...258,004,428
Ensembl chr 1:257,970,345...258,004,434
JBrowse link
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 decreases response to substance ISO CYP2C18 protein results in decreased susceptibility to Chlorpromazine CTD PMID:26477383 NCBI chr 1:258,074,797...258,139,176
Ensembl chr 1:258,074,860...258,139,176
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions
decreases response to substance
decreases activity
affects methylation
ISO [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Chlorpromazine
CYP2C19 protein results in decreased susceptibility to Chlorpromazine
Chlorpromazine results in decreased activity of CYP2C19 protein
CYP2C19 protein affects the methylation of Chlorpromazine
CTD PMID:15135088, PMID:20615392, PMID:23397584, PMID:26477383 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases response to substance ISO CYP2C8 protein results in decreased susceptibility to Chlorpromazine CTD PMID:26477383 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions
decreases response to substance
ISO [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Chlorpromazine; CYP2D6 protein results in increased metabolism of and results in increased activity of Chlorpromazine
CYP2D6 protein results in decreased susceptibility to Chlorpromazine
CTD PMID:19482014, PMID:23397584, PMID:26477383 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity
decreases response to substance
ISO Chlorpromazine results in decreased activity of CYP2E1 protein
CYP2E1 protein results in decreased susceptibility to Chlorpromazine
CTD PMID:15135088, PMID:26477383 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 decreases response to substance ISO CYP3A5 protein results in decreased susceptibility to Chlorpromazine CTD PMID:26477383 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 multiple interactions ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of CYP8B1 mRNA CTD PMID:27344345 NCBI chr 8:130,548,418...130,550,388
Ensembl chr 8:130,548,418...130,550,388
JBrowse link
G Dao D-amino-acid oxidase decreases activity ISO Chlorpromazine results in decreased activity of DAO protein CTD PMID:18615285 NCBI chr12:48,353,691...48,373,647
Ensembl chr12:48,354,196...48,365,784
JBrowse link
G Dcstamp dendrocyte expressed seven transmembrane protein multiple interactions ISO Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA] CTD PMID:21869564 NCBI chr 7:78,642,016...78,651,763
Ensembl chr 7:78,649,875...78,650,906
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression EXP Chlorpromazine results in increased expression of DDIT3 mRNA CTD PMID:25596134 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Depp1 DEPP1, autophagy regulator increases expression ISO Chlorpromazine results in increased expression of DEPP1 mRNA CTD PMID:15342952, PMID:17175557 NCBI chr 4:148,780,330...148,784,566
Ensembl chr 4:148,782,479...148,784,562
JBrowse link
G Drd1 dopamine receptor D1 decreases activity ISO Chlorpromazine results in decreased activity of DRD1 protein CTD PMID:23611293 NCBI chr17:11,099,736...11,104,352
Ensembl chr17:11,101,306...11,103,541
JBrowse link
G Drd2 dopamine receptor D2 decreases response to substance
decreases activity
ISO DRD2 polymorphism results in decreased susceptibility to Chlorpromazine
Chlorpromazine results in decreased activity of DRD2 protein
CTD PMID:15694263, PMID:23611293 NCBI chr 8:53,678,777...53,743,643
Ensembl chr 8:53,678,777...53,743,642
JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression
affects expression
ISO Chlorpromazine analog results in increased expression of DUSP1 mRNA
Chlorpromazine affects the expression of DUSP1 mRNA
CTD PMID:15924885, PMID:20843724 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
JBrowse link
G Dusp9 dual specificity phosphatase 9 decreases expression ISO Chlorpromazine analog results in decreased expression of DUSP9 mRNA CTD PMID:15924885 NCBI chr  X:157,168,143...157,172,068
Ensembl chr  X:157,168,144...157,172,068
JBrowse link
G E2f1 E2F transcription factor 1 decreases expression ISO Chlorpromazine analog results in decreased expression of E2F1 mRNA CTD PMID:15924885 NCBI chr 3:150,062,895...150,073,721
Ensembl chr 3:150,047,826...150,073,721
JBrowse link
G Egr1 early growth response 1 increases expression
multiple interactions
EXP Chlorpromazine results in increased expression of EGR1
[EGR1 binds to CDKN1A promoter] promotes the reaction [Chlorpromazine results in increased expression of CDKN1A mRNA]; EGR1 promotes the reaction [Chlorpromazine results in increased expression of CDKN1A mRNA]; MAPK1 affects the reaction [Chlorpromazine results in increased expression of EGR1]; MAPK3 affects the reaction [Chlorpromazine results in increased expression of EGR1]
CTD PMID:20368687 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Eif1 eukaryotic translation initiation factor 1 increases expression EXP Chlorpromazine results in increased expression of EIF1 mRNA CTD PMID:25596134 NCBI chr10:88,227,455...88,229,546
Ensembl chr10:88,227,360...88,229,765
JBrowse link
G Eno2 enolase 2 increases expression EXP Chlorpromazine results in increased expression of ENO2 mRNA CTD PMID:25596134 NCBI chr 4:157,285,192...157,294,090
Ensembl chr 4:157,285,179...157,294,047
JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha increases expression EXP Chlorpromazine results in increased expression of ERO1A mRNA CTD PMID:25596134 NCBI chr15:19,619,947...19,655,381
Ensembl chr15:19,619,973...19,655,381
JBrowse link
G F2 coagulation factor II decreases expression ISO Chlorpromazine analog results in decreased expression of F2 mRNA CTD PMID:15924885 NCBI chr 3:80,529,468...80,542,993
Ensembl chr 3:80,529,428...80,543,031
JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO Chlorpromazine results in increased expression of FABP1 mRNA CTD PMID:15342952, PMID:17175557 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO Chlorpromazine analog results in increased expression of FAS mRNA CTD PMID:15924885 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fbp1 fructose-bisphosphatase 1 multiple interactions ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of FBP1 mRNA CTD PMID:27344345 NCBI chr17:396,175...417,480
Ensembl chr17:396,180...417,480
JBrowse link
G Fbxo22 F-box protein 22 decreases expression EXP Chlorpromazine results in decreased expression of FBXO22 mRNA CTD PMID:25596134 NCBI chr 8:59,770,032...59,786,061
Ensembl chr 8:59,769,994...59,786,065
JBrowse link
G Fech ferrochelatase decreases expression EXP Chlorpromazine results in decreased expression of FECH mRNA CTD PMID:25596134 NCBI chr18:59,941,992...59,975,192
Ensembl chr18:59,941,992...59,975,192
JBrowse link
G Fetub fetuin B multiple interactions ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of FETUB mRNA CTD PMID:27344345 NCBI chr11:81,648,890...81,660,472
Ensembl chr11:81,648,885...81,660,395
JBrowse link
G Fga fibrinogen alpha chain multiple interactions ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of FGA mRNA CTD PMID:27344345 NCBI chr 2:181,997,562...182,013,726
Ensembl chr 2:182,006,242...182,013,763
JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of FGF2 mRNA CTD PMID:27344345 NCBI chr 2:124,081,072...124,134,133
Ensembl chr 2:124,081,072...124,134,681
JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 decreases expression ISO Chlorpromazine analog results in decreased expression of FGFR1 mRNA CTD PMID:15924885 NCBI chr16:71,265,390...71,319,046
Ensembl chr16:71,266,248...71,319,449
JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase decreases expression EXP Chlorpromazine results in decreased expression of FGR mRNA CTD PMID:25596134 NCBI chr 5:151,172,189...151,199,746
Ensembl chr 5:151,172,206...151,199,745
JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 multiple interactions ISO Chlorpromazine inhibits the reaction [Lipopolysaccharides results in decreased expression of FKBP5 protein] CTD PMID:21034739 NCBI chr20:7,976,704...8,097,290
Ensembl chr20:7,976,713...8,019,020
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit affects expression ISO Chlorpromazine affects the expression of FOS mRNA CTD PMID:20843724 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit affects expression ISO Chlorpromazine affects the expression of FOSB mRNA CTD PMID:20843724 NCBI chr 1:80,214,691...80,221,417
Ensembl chr 1:80,214,494...80,221,710
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression
affects expression
ISO Chlorpromazine analog results in increased expression of FOSL1 mRNA
Chlorpromazine affects the expression of FOSL1 mRNA
CTD PMID:15924885, PMID:20843724 NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066
JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit affects expression ISO Chlorpromazine affects the expression of FOSL2 mRNA CTD PMID:20843724 NCBI chr 6:25,598,936...25,616,995
Ensembl chr 6:25,598,936...25,616,995
JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of FTH1 mRNA CTD PMID:27344345 NCBI chr 1:226,030,940...226,033,228
Ensembl chr 1:226,030,938...226,033,228
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases expression ISO Chlorpromazine analog results in decreased expression of G6PD mRNA CTD PMID:15924885 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gad1 glutamate decarboxylase 1 decreases methylation
multiple interactions
ISO Chlorpromazine results in decreased methylation of GAD1 promoter
Valproic Acid promotes the reaction [Chlorpromazine results in decreased methylation of GAD1 promoter]
CTD PMID:19110320 NCBI chr 3:56,861,440...56,902,139
Ensembl chr 3:56,861,396...56,902,157
JBrowse link
G Gcgr glucagon receptor multiple interactions ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of GCGR mRNA CTD PMID:27344345 NCBI chr10:109,707,863...109,716,253
Ensembl chr10:109,707,962...109,716,128
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit decreases expression EXP Chlorpromazine results in decreased expression of GCLC mRNA CTD PMID:25596134 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression EXP Chlorpromazine results in increased expression of GDF15 mRNA CTD PMID:25596134 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 increases expression ISO Chlorpromazine results in increased expression of GDPD3 mRNA CTD PMID:15342952, PMID:17175557 NCBI chr 1:198,199,032...198,209,178
Ensembl chr 1:198,199,622...198,209,150
JBrowse link
G Gfap glial fibrillary acidic protein affects expression EXP Chlorpromazine affects the expression of GFAP mRNA CTD PMID:31324950 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Gpnmb glycoprotein nmb increases expression EXP Chlorpromazine results in increased expression of GPNMB mRNA CTD PMID:25596134 NCBI chr 4:78,694,447...78,715,685
Ensembl chr 4:78,694,447...78,715,683
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity EXP Chlorpromazine results in decreased activity of GSR protein CTD PMID:6693892 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of GSTA1 mRNA CTD PMID:27344345 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha affects activity EXP Chlorpromazine affects the activity of HIF1A protein CTD PMID:25596134 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression ISO Chlorpromazine results in increased expression of HMGCR mRNA CTD PMID:17052361 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO Chlorpromazine results in increased expression of HMGCS1 mRNA CTD PMID:17052361 NCBI chr 2:52,427,351...52,445,082
Ensembl chr 2:52,431,601...52,445,055
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
affects expression
ISO
EXP
Chlorpromazine results in increased expression of HMOX1 mRNA
Chlorpromazine affects the expression of HMOX1 mRNA
CTD PMID:15924885, PMID:25596134, PMID:31324950 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hpn hepsin increases expression ISO Chlorpromazine results in increased expression of HPN mRNA CTD PMID:15342952, PMID:17175557 NCBI chr 1:89,534,112...89,549,575
Ensembl chr 1:89,534,106...89,543,967
JBrowse link
G Ibsp integrin-binding sialoprotein decreases expression
multiple interactions
EXP Chlorpromazine results in decreased expression of IBSP mRNA
herbimycin inhibits the reaction [Chlorpromazine results in decreased expression of IBSP mRNA]; U 0126 inhibits the reaction [Chlorpromazine results in decreased expression of IBSP mRNA]
CTD PMID:16294319 NCBI chr14:6,801,200...6,813,987
Ensembl chr14:6,801,204...6,813,945
JBrowse link
G Ifng interferon gamma multiple interactions ISO [Chlorpromazine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA CTD PMID:29594315 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Ifnlr1 interferon, lambda receptor 1 increases expression ISO Chlorpromazine results in increased expression of IFNLR1 mRNA CTD PMID:21683644 NCBI chr 5:154,037,243...154,058,862
Ensembl chr 5:154,037,202...154,058,880
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression ISO Chlorpromazine results in increased expression of IGFBP1 mRNA CTD PMID:15924885 NCBI chr14:87,448,716...87,453,783
Ensembl chr14:87,448,692...87,453,785
JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma increases expression ISO Chlorpromazine analog results in increased expression of IKBKG mRNA CTD PMID:15924885 NCBI chr  X:156,254,187...156,280,046
Ensembl chr  X:156,257,173...156,270,748
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Chlorpromazine CTD PMID:19362101 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta decreases expression ISO Chlorpromazine results in decreased expression of IL1B mRNA CTD PMID:29594315 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Chlorpromazine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA; Chlorpromazine inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK1 protein]; Chlorpromazine inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK3 protein] CTD PMID:11014349, PMID:29594315 NCBI chr 2:123,847,150...123,851,854
Ensembl chr 2:123,847,150...123,851,854
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Chlorpromazine CTD PMID:19362101 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Chlorpromazine results in increased expression of INHBE mRNA CTD PMID:15342952, PMID:17175557 NCBI chr 7:70,641,423...70,642,848
Ensembl chr 7:70,640,075...70,643,169
JBrowse link
G Insig2 insulin induced gene 2 decreases expression EXP Chlorpromazine results in decreased expression of INSIG2 mRNA CTD PMID:25596134 NCBI chr13:37,264,818...37,292,718
Ensembl chr13:37,266,312...37,287,458
JBrowse link
G Irs2 insulin receptor substrate 2 multiple interactions EXP Chlorpromazine results in decreased expression of and results in decreased phosphorylation of IRS2 protein; Chlorpromazine results in decreased expression of and results in increased degradation of IRS2 protein CTD PMID:17512020, PMID:18308779 NCBI chr16:83,824,515...83,848,569
Ensembl chr16:83,824,430...83,848,684
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity
ISO Chlorpromazine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Chlorpromazine results in decreased activity of KCNH2 protein
CTD PMID:15071359, PMID:21158687, PMID:24052561 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Kcnn2 potassium calcium-activated channel subfamily N member 2 decreases activity EXP Chlorpromazine results in decreased activity of KCNN2 protein CTD PMID:10915830 NCBI chr18:39,331,894...39,479,574
Ensembl chr18:39,335,377...39,479,257
JBrowse link
G Klf4 Kruppel like factor 4 multiple interactions
decreases expression
ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of KLF4 mRNA
Chlorpromazine results in decreased expression of KLF4 mRNA
CTD PMID:27344345, PMID:30703373 NCBI chr 5:72,283,311...72,287,669
Ensembl chr 5:72,283,313...72,287,669
JBrowse link
G Klkb1 kallikrein B1 multiple interactions ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of KLKB1 mRNA CTD PMID:27344345 NCBI chr16:50,151,127...50,175,407
Ensembl chr16:50,152,008...50,175,458
JBrowse link
G Kng2 kininogen 2 multiple interactions ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of KNG1 mRNA CTD PMID:27344345 NCBI chr11:81,509,185...81,516,759 JBrowse link
G Lats1 large tumor suppressor kinase 1 increases phosphorylation ISO Chlorpromazine results in increased phosphorylation of LATS1 protein CTD PMID:30703373 NCBI chr 1:1,784,078...1,817,310
Ensembl chr 1:1,784,078...1,817,310
JBrowse link
G Ldlr low density lipoprotein receptor increases expression ISO Chlorpromazine results in increased expression of LDLR mRNA CTD PMID:17052361 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
JBrowse link
G Lep leptin increases expression EXP Chlorpromazine results in increased expression of LEP protein CTD PMID:17512020 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Lss lanosterol synthase increases expression ISO Chlorpromazine results in increased expression of LSS mRNA CTD PMID:15342952, PMID:17175557 NCBI chr20:12,844,522...12,870,474
Ensembl chr20:12,842,884...12,870,497
JBrowse link
G Map2 microtubule-associated protein 2 increases expression EXP Chlorpromazine results in increased expression of MAP2 mRNA CTD PMID:15079866 NCBI chr 9:73,204,753...73,462,965
Ensembl chr 9:73,319,710...73,462,972
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP
Chlorpromazine inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK1 protein]
MAPK1 affects the reaction [Chlorpromazine results in increased expression of EGR1]
CTD PMID:11014349, PMID:20368687 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 decreases expression ISO Chlorpromazine analog results in decreased expression of MAPK14 mRNA CTD PMID:15924885 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases expression
multiple interactions
ISO
EXP
Chlorpromazine analog results in decreased expression of MAPK3 mRNA
MAPK3 affects the reaction [Chlorpromazine results in increased expression of EGR1]
Chlorpromazine inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK3 protein]
CTD PMID:11014349, PMID:15924885, PMID:20368687 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO [Chlorpromazine co-treated with lipoteichoic acid] results in increased phosphorylation of MAPK8 protein; Chlorpromazine promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein]; TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipoteichoic acid] results in increased phosphorylation of MAPK8 protein]; TIRAP gene mutant form inhibits the reaction [Chlorpromazine promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein]] CTD PMID:23238562 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 increases expression EXP Chlorpromazine results in increased expression of MAPKAPK2 mRNA CTD PMID:19441803 NCBI chr13:47,785,157...47,871,684
Ensembl chr13:47,785,161...47,831,110
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 decreases expression ISO Chlorpromazine analog results in decreased expression of MCM3 mRNA CTD PMID:15924885 NCBI chr 9:26,914,057...26,932,201
Ensembl chr 9:26,914,057...26,932,201
JBrowse link
G Mcm5 minichromosome maintenance complex component 5 decreases expression ISO Chlorpromazine analog results in decreased expression of MCM5 mRNA CTD PMID:15924885 NCBI chr19:14,523,482...14,561,281
Ensembl chr19:14,523,554...14,561,278
JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression EXP Chlorpromazine results in increased expression of MDM2 mRNA CTD PMID:25596134 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Mitf melanocyte inducing transcription factor increases expression ISO Chlorpromazine results in increased expression of MITF protein CTD PMID:25449126 NCBI chr 4:130,172,484...130,425,496
Ensembl chr 4:130,172,727...130,425,532
JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO Chlorpromazine analog results in decreased expression of MKI67 mRNA CTD PMID:15924885 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Chlorpromazine inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased expression of MMP9 mRNA]; Chlorpromazine inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased secretion of MMP9 protein] CTD PMID:25200491 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Msc musculin decreases expression EXP Chlorpromazine results in decreased expression of MSC mRNA CTD PMID:25596134 NCBI chr 5:3,954,902...3,956,974
Ensembl chr 5:3,955,227...3,956,572
JBrowse link
G Msh2 mutS homolog 2 decreases expression ISO Chlorpromazine results in decreased expression of MSH2 mRNA CTD PMID:15924885 NCBI chr 6:11,215,951...11,274,916
Ensembl chr 6:11,215,963...11,274,932
JBrowse link
G Mst1 macrophage stimulating 1 increases phosphorylation ISO Chlorpromazine results in increased phosphorylation of MST1 protein CTD PMID:30703373 NCBI chr 8:116,857,716...116,862,286
Ensembl chr 8:116,857,684...116,862,423
JBrowse link
G Mt1 metallothionein 1 increases expression EXP Chlorpromazine results in increased expression of MT1A mRNA CTD PMID:8128501 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mybl2 MYB proto-oncogene like 2 decreases expression ISO Chlorpromazine analog results in decreased expression of MYBL2 mRNA CTD PMID:15924885 NCBI chr 3:159,421,638...159,450,087
Ensembl chr 3:159,421,671...159,450,086
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO Chlorpromazine results in decreased expression of MYC mRNA CTD PMID:30703373 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase increases expression EXP Chlorpromazine results in increased expression of NAMPT mRNA CTD PMID:25596134 NCBI chr 6:52,122,085...52,156,473
Ensembl chr 6:52,122,085...52,156,472
JBrowse link
G Nanog Nanog homeobox decreases expression ISO Chlorpromazine results in decreased expression of NANOG mRNA CTD PMID:30703373 NCBI chr 4:155,531,906...155,539,268
Ensembl chr 4:155,531,906...155,539,268
JBrowse link
G Ndufs3 NADH:ubiquinone oxidoreductase core subunit S3 decreases expression EXP Chlorpromazine results in decreased expression of NDUFS3 protein CTD PMID:19441803 NCBI chr 3:79,721,686...79,728,863
Ensembl chr 3:79,721,694...79,728,879
JBrowse link
G Nectin2 nectin cell adhesion molecule 2 multiple interactions ISO Chlorpromazine inhibits the reaction [Cadmium Chloride results in decreased expression of and affects the localization of NECTIN2 protein] CTD PMID:25046863 NCBI chr 1:80,631,449...80,666,617
Ensembl chr 1:80,631,450...80,666,585
JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 decreases expression EXP Chlorpromazine results in decreased expression of NEDD9 mRNA CTD PMID:25596134 NCBI chr17:22,984,792...23,179,701
Ensembl chr17:22,984,844...23,179,701
JBrowse link
G Nefh neurofilament heavy affects expression EXP Chlorpromazine affects the expression of NEFH mRNA CTD PMID:31324950 NCBI chr14:85,181,572...85,191,557
Ensembl chr14:85,181,572...85,191,557
JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA] CTD PMID:21869564 NCBI chr18:77,203,517...77,322,690
Ensembl chr18:77,203,525...77,322,690
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 decreases expression
affects activity
EXP Chlorpromazine results in decreased expression of NFE2L2 mRNA
Chlorpromazine affects the activity of NFE2L2 protein
CTD PMID:25596134 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Ninj1 ninjurin 1 increases expression EXP Chlorpromazine results in increased expression of NINJ1 mRNA CTD PMID:25596134 NCBI chr17:15,866,235...15,881,284
Ensembl chr17:15,866,237...15,881,327
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Chlorpromazine results in increased expression of NR0B2 mRNA CTD PMID:17175557 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 decreases expression EXP Chlorpromazine results in decreased expression of NR1H4 mRNA CTD PMID:27765674, PMID:28391356 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases expression
multiple interactions
ISO Chlorpromazine analog results in increased expression of NR1I2 mRNA
[Chlorpromazine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CTD PMID:15924885, PMID:17041008 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity
increases expression
multiple interactions
ISO Chlorpromazine results in increased activity of NR1I3 protein
Chlorpromazine results in increased expression of NR1I3 mRNA
[Chlorpromazine co-treated with Cholic Acids] affects the expression of NR1I3 mRNA; [Chlorpromazine results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; Chlorpromazine inhibits the reaction [Androstenols inhibits the reaction [NR1I3 protein results in increased expression of CYP2B6 mRNA]]
NR1I3 protein affects the reaction [Chlorpromazine results in increased expression of CYP2B10 mRNA]; NR1I3 protein affects the reaction [Chlorpromazine results in increased expression of CYP3A11 mRNA]
CTD PMID:10037683, PMID:12049174, PMID:12948398, PMID:17041008, PMID:22310298, PMID:27344345 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO Chlorpromazine inhibits the reaction [Corticosterone results in increased activity of NR3C1 protein] CTD PMID:16581232 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Chlorpromazine results in increased expression of NUPR1 mRNA CTD PMID:15342952, PMID:17175557 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524
JBrowse link
G Orc1 origin recognition complex, subunit 1 decreases expression ISO Chlorpromazine analog results in decreased expression of ORC1 mRNA CTD PMID:15924885 NCBI chr 5:128,186,651...128,212,901
Ensembl chr 5:128,190,708...128,210,445
JBrowse link
G Orm1 orosomucoid 1 affects binding
multiple interactions
ISO Chlorpromazine binds to ORM1 protein alternative form
Chlorpromazine inhibits the reaction [Warfarin binds to ORM1 protein alternative form]
CTD PMID:8946472 NCBI chr 5:79,179,668...79,182,820
Ensembl chr 5:79,179,417...79,182,820
JBrowse link
G Pdia2 protein disulfide isomerase family A, member 2 increases expression ISO Chlorpromazine analog results in increased expression of PDIA2 mRNA CTD PMID:15924885
G Pdia5 protein disulfide isomerase family A, member 5 decreases expression EXP Chlorpromazine results in decreased expression of PDIA5 mRNA CTD PMID:25596134 NCBI chr11:68,493,035...68,578,999
Ensembl chr11:68,493,035...68,578,995
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 increases expression EXP Chlorpromazine results in increased expression of PDK1 mRNA CTD PMID:25596134 NCBI chr 3:58,530,870...58,561,494
Ensembl chr 3:58,530,870...58,558,027
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 increases expression EXP Chlorpromazine results in increased expression of PDK4 mRNA CTD PMID:25596134 NCBI chr 4:30,546,772...30,556,774
Ensembl chr 4:30,546,664...30,556,814
JBrowse link
G Phyh phytanoyl-CoA 2-hydroxylase increases expression ISO Chlorpromazine results in increased expression of PHYH mRNA CTD PMID:15342952 NCBI chr17:77,287,580...77,304,482
Ensembl chr17:77,287,188...77,304,530
JBrowse link
G Pias1 protein inhibitor of activated STAT, 1 increases expression ISO Chlorpromazine results in increased expression of PIAS1 mRNA CTD PMID:21683644 NCBI chr 8:67,771,720...67,869,015
Ensembl chr 8:67,771,720...67,869,019
JBrowse link
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase increases expression ISO Chlorpromazine analog results in increased expression of PIM1 mRNA CTD PMID:15924885 NCBI chr20:8,165,423...8,169,557
Ensembl chr20:8,165,307...8,169,555
JBrowse link
G Pir pirin decreases expression EXP Chlorpromazine results in decreased expression of PIR mRNA CTD PMID:25596134 NCBI chr  X:31,852,322...31,968,152
Ensembl chr  X:31,852,323...31,968,152
JBrowse link
G Plin2 perilipin 2 increases expression EXP Chlorpromazine results in increased expression of PLIN2 mRNA CTD PMID:25596134 NCBI chr 5:104,984,413...105,010,863
Ensembl chr 5:104,984,414...105,010,857
JBrowse link
G Pmepa1 prostate transmembrane protein, androgen induced 1 decreases expression EXP Chlorpromazine results in decreased expression of PMEPA1 mRNA CTD PMID:25596134 NCBI chr 3:171,295,630...171,342,662
Ensembl chr 3:171,294,856...171,342,646
JBrowse link
G Pola1 DNA polymerase alpha 1, catalytic subunit decreases expression ISO Chlorpromazine analog results in decreased expression of POLA1 mRNA CTD PMID:15924885 NCBI chr  X:62,382,604...62,698,830
Ensembl chr  X:62,382,608...62,698,830
JBrowse link
G Pold4 DNA polymerase delta 4, accessory subunit increases expression ISO Chlorpromazine analog results in increased expression of POLD4 mRNA CTD PMID:15924885 NCBI chr 1:219,480,841...219,483,244
Ensembl chr 1:219,481,575...219,483,241
JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases expression ISO Chlorpromazine results in decreased expression of POU5F1 mRNA CTD PMID:30703373 NCBI chr20:3,747,231...3,751,994
Ensembl chr20:3,747,221...3,751,994
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects activity EXP Chlorpromazine affects the activity of PPARG protein CTD PMID:25596134 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression EXP Chlorpromazine results in increased expression of PPP1R15A mRNA CTD PMID:25596134 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 decreases phosphorylation EXP Chlorpromazine results in decreased phosphorylation of PRKAA1 protein CTD PMID:17512020 NCBI chr 2:54,857,688...54,893,404
Ensembl chr 2:54,857,688...54,893,404
JBrowse link
G Prl prolactin increases expression ISO Chlorpromazine results in increased expression of PRL protein CTD PMID:718334, PMID:996201 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Rara retinoic acid receptor, alpha decreases expression EXP Chlorpromazine results in decreased expression of RARA mRNA CTD PMID:18246545 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
JBrowse link
G Rnd1 Rho family GTPase 1 decreases expression EXP Chlorpromazine results in decreased expression of RND1 mRNA CTD PMID:25596134 NCBI chr 7:140,349,138...140,356,209
Ensembl chr 7:140,349,138...140,356,209
JBrowse link
G Rnd3 Rho family GTPase 3 decreases expression EXP Chlorpromazine results in decreased expression of RND3 mRNA CTD PMID:25596134 NCBI chr 3:36,643,374...36,660,727
Ensembl chr 3:36,642,587...36,660,758
JBrowse link
G Rnf121 ring finger protein 121 decreases expression EXP Chlorpromazine results in decreased expression of RNF121 mRNA CTD PMID:25596134 NCBI chr 1:167,095,916...167,165,257
Ensembl chr 1:167,095,962...167,165,265
JBrowse link
G Runx1 RUNX family transcription factor 1 increases expression EXP Chlorpromazine results in increased expression of RUNX1 mRNA CTD PMID:25596134 NCBI chr11:32,765,147...33,003,061
Ensembl chr11:32,769,165...33,003,021
JBrowse link
G Rxrg retinoid X receptor gamma affects response to substance ISO RXRG protein affects the susceptibility to Chlorpromazine CTD PMID:10336693 NCBI chr13:85,818,473...85,868,555
Ensembl chr13:85,818,427...85,868,552
JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 increases expression EXP Chlorpromazine results in increased expression of SAT1 mRNA CTD PMID:25596134 NCBI chr  X:43,626,480...43,629,767
Ensembl chr  X:43,625,169...43,629,765
JBrowse link
G Sc5d sterol-C5-desaturase increases expression ISO Chlorpromazine results in increased expression of SC5D mRNA CTD PMID:17052361 NCBI chr 8:46,525,406...46,537,014
Ensembl chr 8:46,525,400...46,537,050
JBrowse link
G Serpina3m serpin family A member 3M increases expression ISO Chlorpromazine results in increased expression of SERPINA3 mRNA CTD PMID:15342952, PMID:17175557 NCBI chr 6:127,808,785...127,816,067
Ensembl chr 6:127,808,785...127,816,055
JBrowse link
G Sesn1 sestrin 1 decreases expression EXP Chlorpromazine results in decreased expression of SESN1 mRNA CTD PMID:25596134 NCBI chr20:46,667,116...46,758,306
Ensembl chr20:46,667,121...46,758,305
JBrowse link
G Sik1 salt-inducible kinase 1 decreases expression EXP Chlorpromazine results in decreased expression of SIK1 mRNA CTD PMID:25596134 NCBI chr20:10,670,747...10,680,279
Ensembl chr20:10,668,411...10,680,283
JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression EXP Chlorpromazine results in decreased expression of SLC10A1 mRNA CTD PMID:27765674, PMID:28391356 NCBI chr 6:104,617,730...104,631,355
Ensembl chr 6:104,617,730...104,631,355
JBrowse link
G Slc12a8 solute carrier family 12, member 8 increases expression EXP Chlorpromazine results in increased expression of SLC12A8 mRNA CTD PMID:25596134 NCBI chr11:70,344,771...70,499,202
Ensembl chr11:70,344,797...70,499,200
JBrowse link
G Slc19a1 solute carrier family 19 member 1 multiple interactions
decreases activity
EXP Chlorpromazine inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]
Chlorpromazine results in decreased activity of SLC19A1 protein
CTD PMID:17482559 NCBI chr20:12,334,675...12,354,517
Ensembl chr20:12,334,676...12,352,377
JBrowse link
G Slc1a5 solute carrier family 1 member 5 increases expression EXP Chlorpromazine results in increased expression of SLC1A5 mRNA CTD PMID:25596134 NCBI chr 1:78,710,686...78,724,789
Ensembl chr 1:78,710,539...78,724,794
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Chlorpromazine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc22a7 solute carrier family 22 member 7 multiple interactions ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of SLC22A7 mRNA CTD PMID:27344345 NCBI chr 9:16,925,321...16,931,119
Ensembl chr 9:16,924,520...16,931,766
JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression ISO Chlorpromazine results in decreased expression of SLC2A3 mRNA CTD PMID:15342952 NCBI chr 4:155,549,991...155,626,018
Ensembl chr 4:155,408,233...155,631,856
JBrowse link
G Slc31a1 solute carrier family 31 member 1 multiple interactions ISO Chlorpromazine inhibits the reaction [Copper affects the localization of SLC31A1 protein] CTD PMID:12501239 NCBI chr 5:78,222,504...78,249,358
Ensembl chr 5:78,222,504...78,249,358
JBrowse link
G Slc3a2 solute carrier family 3 member 2 increases expression EXP Chlorpromazine results in increased expression of SLC3A2 mRNA CTD PMID:25596134 NCBI chr 1:224,906,566...224,921,029
Ensembl chr 1:224,906,554...224,921,092
JBrowse link
G Slc51b solute carrier family 51 subunit beta multiple interactions ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of SLC51B mRNA CTD PMID:27344345 NCBI chr 8:70,930,196...70,938,559
Ensembl chr 8:70,930,347...70,932,986
JBrowse link
G Slc6a6 solute carrier family 6 member 6 increases expression EXP Chlorpromazine results in increased expression of SLC6A6 mRNA CTD PMID:25596134 NCBI chr 4:123,638,619...123,713,469
Ensembl chr 4:123,642,210...123,713,464
JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 decreases expression EXP Chlorpromazine results in decreased expression of SLCO2B1 mRNA CTD PMID:25596134 NCBI chr 1:164,623,313...164,671,612
Ensembl chr 1:164,623,599...164,671,577
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP Chlorpromazine inhibits the reaction [Copper inhibits the reaction [Trientine results in decreased activity of SOD1 protein]] CTD PMID:22362149 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Sox2 SRY-box transcription factor 2 decreases expression ISO Chlorpromazine results in decreased expression of SOX2 mRNA CTD PMID:30703373 NCBI chr 2:121,165,137...121,167,545
Ensembl chr 2:121,165,137...121,167,545
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of SPP1 mRNA CTD PMID:27344345 NCBI chr14:6,673,686...6,679,965
Ensembl chr14:6,673,686...6,679,901
JBrowse link
G Spsb1 splA/ryanodine receptor domain and SOCS box containing 1 increases expression EXP Chlorpromazine results in increased expression of SPSB1 mRNA CTD PMID:25596134 NCBI chr 5:166,913,734...166,978,534
Ensembl chr 5:166,913,735...166,926,636
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions EXP Chlorpromazine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased phosphorylation of SRC protein] CTD PMID:29702141 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions ISO Chlorpromazine results in increased cleavage of and results in increased activity of SREBF2 protein CTD PMID:17052361 NCBI chr 7:123,381,082...123,438,605
Ensembl chr 7:123,381,077...123,438,603
JBrowse link
G Strbp spermatid perinuclear RNA binding protein increases expression EXP Chlorpromazine results in increased expression of STRBP mRNA CTD PMID:25596134 NCBI chr 3:21,817,680...21,956,988
Ensembl chr 3:21,828,298...21,904,270
JBrowse link
G Sts steroid sulfatase multiple interactions ISO Chlorpromazine inhibits the reaction [Tretinoin results in increased activity of STS protein] CTD PMID:16178010 NCBI chr  X:45,420,418...45,428,748
Ensembl chr  X:45,420,596...45,428,750
JBrowse link
G Tagln transgelin decreases expression ISO Chlorpromazine results in decreased expression of TAGLN mRNA CTD PMID:17175557 NCBI chr 8:50,222,895...50,228,369
Ensembl chr 8:50,222,896...50,231,357
JBrowse link
G Tf transferrin affects localization ISO Chlorpromazine affects the localization of TF protein CTD PMID:12501239 NCBI chr 8:111,694,570...111,721,275
Ensembl chr 8:111,673,547...111,721,333
JBrowse link
G Tfdp1 transcription factor Dp-1 decreases expression ISO Chlorpromazine analog results in decreased expression of TFDP1 mRNA CTD PMID:15924885 NCBI chr16:81,088,642...81,127,244
Ensembl chr16:81,089,292...81,127,257
JBrowse link
G Tiparp TCDD-inducible poly(ADP-ribose) polymerase increases expression EXP Chlorpromazine results in increased expression of TIPARP mRNA CTD PMID:25596134 NCBI chr 2:157,316,293...157,342,979
Ensembl chr 2:157,316,266...157,341,469
JBrowse link
G Tirap TIR domain containing adaptor protein multiple interactions ISO TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TNF protein]; TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipoteichoic acid] results in increased expression of TNF protein]; TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipoteichoic acid] results in increased phosphorylation of MAPK8 protein]; TIRAP gene mutant form inhibits the reaction [Chlorpromazine promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein]]; TIRAP protein results in increased susceptibility to [Chlorpromazine co-treated with lipopolysaccharide, Escherichia coli O111 B4]; TIRAP protein results in increased susceptibility to [Chlorpromazine co-treated with lipoteichoic acid] CTD PMID:23238562 NCBI chr 8:36,382,029...36,399,625
Ensembl chr 8:36,385,353...36,388,224
JBrowse link
G Tnf tumor necrosis factor decreases expression
increases response to substance
multiple interactions
ISO Chlorpromazine analog results in decreased expression of TNF protein; Chlorpromazine results in decreased expression of TNF mRNA
TNF protein results in increased susceptibility to Chlorpromazine
[Chlorpromazine co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TNF protein; [Chlorpromazine co-treated with lipoteichoic acid] results in increased expression of TNF protein; Chlorpromazine inhibits the reaction [[hydroquinone results in increased expression of TNF protein] which results in increased susceptibility to Methacholine Chloride]; Chlorpromazine inhibits the reaction [hydroquinone results in increased expression of TNF protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased susceptibility to Chlorpromazine]; TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TNF protein]; TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipoteichoic acid] results in increased expression of TNF protein]
[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Chlorpromazine; Chlorpromazine results in decreased expression of and results in decreased activity of TNF protein
CTD PMID:8550079, PMID:15052360, PMID:19362101, PMID:20371967, PMID:22414385, PMID:23238562 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfaip8 TNF alpha induced protein 8 increases expression EXP Chlorpromazine results in increased expression of TNFAIP8 mRNA CTD PMID:25596134 NCBI chr18:44,664,310...44,779,914
Ensembl chr18:44,716,226...44,779,914
JBrowse link
G Tnfrsf14 TNF receptor superfamily member 14 increases expression ISO Chlorpromazine analog results in increased expression of TNFRSF14 mRNA CTD PMID:15924885 NCBI chr 5:172,328,259...172,337,221
Ensembl chr 5:172,328,262...172,335,892
JBrowse link
G Tnfsf11 TNF superfamily member 11 decreases activity
multiple interactions
ISO Chlorpromazine results in decreased activity of TNFSF11; Chlorpromazine results in decreased activity of TNFSF11 protein
Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]; Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA]; Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of CAR2 mRNA]; Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA]; Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]
CTD PMID:21869564 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
G Tp53 tumor protein p53 affects activity EXP Chlorpromazine affects the activity of TP53 protein CTD PMID:25596134 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Trafd1 TRAF type zinc finger domain containing 1 decreases expression EXP Chlorpromazine results in decreased expression of TRAFD1 mRNA CTD PMID:25596134 NCBI chr12:40,695,520...40,709,438
Ensembl chr12:40,695,520...40,709,462
JBrowse link
G Tuba1a tubulin, alpha 1A decreases expression ISO Chlorpromazine results in decreased expression of TUBA1A mRNA CTD PMID:27015953 NCBI chr 7:140,637,287...140,640,953
Ensembl chr 7:140,637,287...140,640,953
JBrowse link
G Txn1 thioredoxin 1 decreases expression EXP Chlorpromazine results in decreased expression of TXN1 mRNA CTD PMID:25596134 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of TXNRD1 mRNA CTD PMID:27344345 NCBI chr 7:26,946,124...26,984,400
Ensembl chr 7:26,946,125...26,984,400
JBrowse link
G Tyr tyrosinase increases expression ISO Chlorpromazine results in increased expression of TYR protein CTD PMID:25449126 NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802
JBrowse link
G Ung uracil-DNA glycosylase decreases expression ISO Chlorpromazine analog results in decreased expression of UNG mRNA CTD PMID:15924885 NCBI chr12:48,246,593...48,255,547
Ensembl chr12:48,246,569...48,254,822
JBrowse link
G Unkl unk like zinc finger decreases expression EXP Chlorpromazine results in decreased expression of UNKL mRNA CTD PMID:25596134 NCBI chr10:14,547,126...14,593,090
Ensembl chr10:14,547,172...14,590,762
JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO Chlorpromazine analog results in increased expression of VEGFA mRNA CTD PMID:15924885 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vegfb vascular endothelial growth factor B increases expression EXP Chlorpromazine results in increased expression of VEGFB mRNA CTD PMID:25596134 NCBI chr 1:222,237,000...222,242,786
Ensembl chr 1:222,239,022...222,242,644
JBrowse link
G Wars1 tryptophanyl-tRNA synthetase 1 increases expression EXP Chlorpromazine results in increased expression of WARS1 mRNA CTD PMID:25596134 NCBI chr 6:132,771,026...132,802,262
Ensembl chr 6:132,771,021...132,802,210
JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Chlorpromazine results in increased expression of WIPI1 mRNA CTD PMID:15342952, PMID:17175557 NCBI chr10:97,859,730...97,896,949
Ensembl chr10:97,859,727...97,896,525
JBrowse link
G Xbp1 X-box binding protein 1 affects activity
decreases expression
EXP Chlorpromazine affects the activity of XBP1 protein
Chlorpromazine results in decreased expression of XBP1 mRNA
CTD PMID:25596134 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link
G Xpc XPC complex subunit, DNA damage recognition and repair factor decreases expression EXP Chlorpromazine results in decreased expression of XPC mRNA CTD PMID:25596134 NCBI chr 4:123,134,457...123,161,985
Ensembl chr 4:123,134,457...123,161,985
JBrowse link
G Xrcc4 X-ray repair cross complementing 4 decreases expression ISO Chlorpromazine results in decreased expression of XRCC4 mRNA CTD PMID:15924885 NCBI chr 2:18,674,496...18,927,463
Ensembl chr 2:18,677,220...18,927,365
JBrowse link
G Yap1 Yes1 associated transcriptional regulator multiple interactions ISO Chlorpromazine results in decreased expression of and results in increased phosphorylation of and affects the localization of YAP1 protein CTD PMID:30703373 NCBI chr 8:6,133,014...6,204,240
Ensembl chr 8:6,135,493...6,203,579
JBrowse link
chlorprothixene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htr1a 5-hydroxytryptamine receptor 1A multiple interactions ISO Chlorprothixene inhibits the reaction [(2-(2',6'-dimethoxy)phenoxyethylamino)methylbenzo-1,4-dioxane binds to HTR1A protein] CTD PMID:2891550 NCBI chr 2:36,246,628...36,247,896
Ensembl chr 2:36,246,628...36,247,896
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Chlorprothixene results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Prl prolactin increases secretion ISO Chlorprothixene results in increased secretion of PRL protein CTD PMID:10525070 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
clidinium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO clidinium inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
clomiphene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd2 abhydrolase domain containing 2, acylglycerol lipase decreases expression ISO Clomiphene results in decreased expression of ABHD2 mRNA CTD PMID:26865669 NCBI chr 1:140,998,240...141,087,405
Ensembl chr 1:140,998,240...141,087,405
JBrowse link
G Ar androgen receptor affects binding
multiple interactions
EXP
ISO
Clomiphene binds to AR protein
Clomiphene binds to and results in decreased activity of AR protein
CTD PMID:14565775, PMID:25752796 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Ca12 carbonic anhydrase 12 decreases expression ISO Clomiphene results in decreased expression of CA12 mRNA CTD PMID:26865669 NCBI chr 8:72,405,770...72,461,425
Ensembl chr 8:72,405,748...72,460,240
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Clomiphene results in decreased expression of CCND1 mRNA CTD PMID:26865669 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccng2 cyclin G2 increases expression ISO Clomiphene results in increased expression of CCNG2 mRNA CTD PMID:26865669 NCBI chr14:16,267,572...16,276,068
Ensembl chr14:16,267,573...16,276,068
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression ISO Clomiphene results in decreased expression of CXCL12 mRNA CTD PMID:26865669 NCBI chr 4:149,261,044...149,273,891
Ensembl chr 4:149,261,044...149,273,891
JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 decreases expression ISO Clomiphene results in decreased expression of DKK1 protein CTD PMID:21851939 NCBI chr 1:248,952,896...248,956,579
Ensembl chr 1:248,895,738...248,898,607
JBrowse link
G Efna1 ephrin A1 increases expression ISO Clomiphene results in increased expression of EFNA1 mRNA CTD PMID:26865669 NCBI chr 2:188,588,808...188,596,156
Ensembl chr 2:188,588,796...188,596,222
JBrowse link
G Egr3 early growth response 3 decreases expression ISO Clomiphene results in decreased expression of EGR3 mRNA CTD PMID:26865669 NCBI chr15:51,756,683...51,762,080
Ensembl chr15:51,756,736...51,760,722
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
affects binding
ISO Clomiphene binds to and results in decreased activity of ESR1 protein; Clomiphene inhibits the reaction [16 alpha-iodoestradiol binds to ESR1 protein]; Clomiphene promotes the reaction [ESR1 protein alternative form binds to ESR1 protein alternative form]
Clomiphene binds to ESR1 protein
CTD PMID:9048584, PMID:15521089, PMID:19233257, PMID:25012808, PMID:25752796, PMID:26865669 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 increases activity
multiple interactions
affects binding
EXP
ISO
Clomiphene results in increased activity of ESR2 protein
Clomiphene binds to and results in decreased activity of ESR2 protein
Clomiphene binds to ESR2 protein
Clomiphene inhibits the reaction [16 alpha-iodoestradiol binds to ESR2 protein]
CTD PMID:9048584, PMID:12224631, PMID:19211805, PMID:25752796 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO Clomiphene results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 2:225,310,686...225,322,281
Ensembl chr 2:225,310,624...225,322,272
JBrowse link
G F5 coagulation factor V affects response to substance ISO F5 gene polymorphism affects the susceptibility to Clomiphene CTD PMID:19371211 NCBI chr13:82,479,997...82,535,540
Ensembl chr13:82,479,998...82,535,534
JBrowse link
G Foxc1 forkhead box C1 decreases expression ISO Clomiphene results in decreased expression of FOXC1 mRNA CTD PMID:26865669 NCBI chr17:33,947,501...33,951,484
Ensembl chr17:33,947,506...33,951,484
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions
increases expression
ISO Clomiphene promotes the reaction [Alcohols results in increased expression of FSHB protein]
Clomiphene results in increased expression of FSHB protein
CTD PMID:1915937, PMID:8590623 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 multiple interactions ISO Clomiphene inhibits the reaction [Estradiol promotes the reaction [GNRH1 protein results in increased secretion of PRL protein]] CTD PMID:17054466 NCBI chr15:44,441,856...44,446,064
Ensembl chr15:44,442,555...44,442,875
Ensembl chr15:44,442,555...44,442,875
JBrowse link
G Id3 inhibitor of DNA binding 3, HLH protein increases expression ISO Clomiphene results in increased expression of ID3 mRNA CTD PMID:26865669 NCBI chr 5:154,489,603...154,491,172
Ensembl chr 5:154,489,590...154,491,223
JBrowse link
G Itgb3 integrin subunit beta 3 decreases expression ISO Clomiphene results in decreased expression of ITGB3 protein CTD PMID:15749485 NCBI chr10:92,667,869...92,783,413
Ensembl chr10:92,667,869...92,783,410
JBrowse link
G Jak2 Janus kinase 2 decreases expression ISO Clomiphene results in decreased expression of JAK2 mRNA CTD PMID:26865669 NCBI chr 1:247,398,667...247,457,521
Ensembl chr 1:247,398,598...247,458,509
JBrowse link
G Kynu kynureninase increases expression ISO Clomiphene results in increased expression of KYNU mRNA CTD PMID:26865669 NCBI chr 3:28,416,926...28,566,939
Ensembl chr 3:28,416,954...28,566,928
JBrowse link
G Lhb luteinizing hormone subunit beta increases secretion
multiple interactions
ISO Clomiphene results in increased secretion of LHB protein
Clomiphene promotes the reaction [Alcohols results in increased expression of LHB protein]; PRL protein inhibits the reaction [Clomiphene results in increased secretion of LHB protein]
CTD PMID:3891423, PMID:8590623 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Lif LIF, interleukin 6 family cytokine increases expression ISO Clomiphene results in increased expression of LIF mRNA CTD PMID:21851939 NCBI chr14:84,482,652...84,500,574
Ensembl chr14:84,482,674...84,500,642
JBrowse link
G Myb MYB proto-oncogene, transcription factor decreases expression ISO Clomiphene results in decreased expression of MYB mRNA CTD PMID:26865669 NCBI chr 1:16,658,178...16,690,135
Ensembl chr 1:16,659,442...16,687,817
JBrowse link
G Mybl1 MYB proto-oncogene like 1 decreases expression ISO Clomiphene results in decreased expression of MYBL1 mRNA CTD PMID:26865669 NCBI chr 5:9,279,756...9,315,112
Ensembl chr 5:9,279,970...9,315,114
JBrowse link
G Nmrk1 nicotinamide riboside kinase 1 decreases expression ISO Clomiphene results in decreased expression of NMRK1 mRNA CTD PMID:26865669 NCBI chr 1:234,721,992...234,749,452
Ensembl chr 1:234,721,974...234,749,447
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions
ISO Clomiphene results in increased activity of NR1I2 protein
[Clomiphene results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
CTD PMID:25455453 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Olfm1 olfactomedin 1 decreases expression ISO Clomiphene results in decreased expression of OLFM1 mRNA CTD PMID:26865669 NCBI chr 3:6,761,031...6,798,739
Ensembl chr 3:6,773,813...6,798,737
JBrowse link
G Pdzk1 PDZ domain containing 1 decreases expression ISO Clomiphene results in decreased expression of PDZK1 mRNA CTD PMID:26865669 NCBI chr 2:198,965,685...198,999,323
Ensembl chr 2:198,965,685...198,999,323
JBrowse link
G Pgr progesterone receptor increases expression
multiple interactions
ISO Clomiphene results in increased expression of PGR protein
Clomiphene binds to and results in decreased activity of PGR protein
CTD PMID:15749485, PMID:25752796 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 increases expression ISO Clomiphene results in increased expression of PIK3R3 mRNA CTD PMID:26865669 NCBI chr 5:135,069,972...135,145,633
Ensembl chr 5:135,074,297...135,142,488
JBrowse link
G Prkce protein kinase C, epsilon affects localization ISO Clomiphene affects the localization of PRKCE protein CTD PMID:9714066 NCBI chr 6:9,483,400...9,973,396
Ensembl chr 6:9,790,422...9,973,396
JBrowse link
G Prl prolactin multiple interactions ISO Clomiphene inhibits the reaction [Estradiol promotes the reaction [GNRH1 protein results in increased secretion of PRL protein]]; Clomiphene inhibits the reaction [Estradiol results in increased secretion of PRL protein]; PRL protein inhibits the reaction [Clomiphene results in increased secretion of LHB protein] CTD PMID:3891423, PMID:17054466 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Prss23 serine protease 23 decreases expression ISO Clomiphene results in decreased expression of PRSS23 mRNA CTD PMID:26865669 NCBI chr 1:153,732,528...153,742,111
Ensembl chr 1:153,732,532...153,752,541
JBrowse link
G Ptges prostaglandin E synthase decreases expression ISO Clomiphene results in decreased expression of PTGES mRNA CTD PMID:26865669 NCBI chr 3:9,727,408...9,738,752
Ensembl chr 3:9,727,408...9,738,752
JBrowse link
G Rbbp8 RB binding protein 8, endonuclease decreases expression ISO Clomiphene results in decreased expression of RBBP8 mRNA CTD PMID:26865669 NCBI chr18:3,134,630...3,227,702
Ensembl chr18:3,162,543...3,227,688
JBrowse link
G Rcl1 RNA terminal phosphate cyclase-like 1 decreases expression ISO Clomiphene results in decreased expression of RCL1 mRNA CTD PMID:26865669 NCBI chr 1:247,228,012...247,272,369
Ensembl chr 1:247,228,061...247,305,693
JBrowse link
G Ret ret proto-oncogene decreases expression ISO Clomiphene results in decreased expression of RET mRNA CTD PMID:26865669 NCBI chr 4:150,202,170...150,249,196
Ensembl chr 4:150,202,058...150,244,372
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 decreases expression ISO Clomiphene results in decreased expression of SGK1 mRNA CTD PMID:26865669 NCBI chr 1:24,185,451...24,302,309
Ensembl chr 1:24,185,435...24,302,298
JBrowse link
G Sgk3 serum/glucocorticoid regulated kinase family, member 3 decreases expression ISO Clomiphene results in decreased expression of SGK3 mRNA CTD PMID:26865669 NCBI chr 5:9,046,889...9,094,740
Ensembl chr 5:9,048,614...9,094,616
JBrowse link
G Shbg sex hormone binding globulin affects binding ISO Clomiphene binds to SHBG protein CTD PMID:25349334 NCBI chr10:56,219,861...56,237,354
Ensembl chr10:56,219,858...56,223,245
JBrowse link
G Siah2 siah E3 ubiquitin protein ligase 2 decreases expression ISO Clomiphene results in decreased expression of SIAH2 mRNA CTD PMID:26865669 NCBI chr 2:148,874,151...148,891,900
Ensembl chr 2:148,874,151...148,891,900
JBrowse link
G Smox spermine oxidase decreases expression ISO Clomiphene results in decreased expression of SMOX mRNA CTD PMID:26865669 NCBI chr 3:124,068,796...124,103,726
Ensembl chr 3:124,068,865...124,102,240
JBrowse link
G Ssbp2 single-stranded DNA binding protein 2 increases expression ISO Clomiphene results in increased expression of SSBP2 mRNA CTD PMID:26865669 NCBI chr 2:20,416,795...20,707,838
Ensembl chr 2:20,431,243...20,702,515
JBrowse link
G Svil supervillin decreases expression ISO Clomiphene results in decreased expression of SVIL mRNA CTD PMID:26865669 NCBI chr17:55,230,298...55,425,967
Ensembl chr17:55,230,298...55,346,279
JBrowse link
G Tfap2a transcription factor AP-2 alpha increases expression ISO Clomiphene results in increased expression of TFAP2A mRNA CTD PMID:26865669 NCBI chr17:24,653,342...24,670,457
Ensembl chr17:24,654,902...24,670,457
JBrowse link
G Tfap2c transcription factor AP-2 gamma decreases expression ISO Clomiphene results in decreased expression of TFAP2C mRNA CTD PMID:26865669 NCBI chr 3:170,550,314...170,558,197
Ensembl chr 3:170,550,314...170,558,194
JBrowse link
G Tfpi tissue factor pathway inhibitor increases expression ISO Clomiphene results in increased expression of TFPI mRNA CTD PMID:26865669 NCBI chr 3:71,852,738...71,902,127
Ensembl chr 3:71,852,744...71,893,618
JBrowse link
cyproheptadine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gh1 growth hormone 1 increases expression ISO Cyproheptadine results in increased expression of GH1 protein CTD PMID:642945 NCBI chr10:94,486,204...94,488,181
Ensembl chr10:94,486,205...94,488,180
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions ISO Cyproheptadine binds to and results in decreased activity of HTR2A protein CTD PMID:17031071 NCBI chr15:56,666,152...56,732,469
Ensembl chr15:56,666,012...56,735,382
JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 affects binding
multiple interactions
ISO Cyproheptadine binds to HTR7 protein
Cyproheptadine inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]
CTD PMID:20827463 NCBI chr 1:254,547,964...254,671,811
Ensembl chr 1:254,547,620...254,671,778
JBrowse link
G Kcnn2 potassium calcium-activated channel subfamily N member 2 decreases activity EXP Cyproheptadine results in decreased activity of KCNN2 protein CTD PMID:10915830 NCBI chr18:39,331,894...39,479,574
Ensembl chr18:39,335,377...39,479,257
JBrowse link
G Pomc proopiomelanocortin decreases secretion ISO Cyproheptadine results in decreased secretion of POMC protein CTD PMID:642945 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Prl prolactin decreases secretion ISO Cyproheptadine results in decreased secretion of PRL protein CTD PMID:642945 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Cyproheptadine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions ISO Cyproheptadine affects the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine] CTD PMID:19821448 NCBI chr10:39,201,101...39,228,090
Ensembl chr10:39,201,107...39,323,853
JBrowse link
dextropropoxyphene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects response to substance ISO ABCB1A protein affects the susceptibility to Dextropropoxyphene CTD PMID:15502009 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B affects response to substance ISO ABCB1B protein affects the susceptibility to Dextropropoxyphene CTD PMID:15502009 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Ces1d carboxylesterase 1D affects binding ISO Dextropropoxyphene binds to CES1 protein CTD PMID:10381793 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Ces2h carboxylesterase 2H affects binding ISO Dextropropoxyphene binds to CES2 protein CTD PMID:10381793 NCBI chr19:37,052,555...37,067,176
Ensembl chr19:37,052,556...37,067,156
JBrowse link
G Oprd1 opioid receptor, delta 1 multiple interactions
affects binding
EXP [Dextropropoxyphene binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Dextropropoxyphene binds to OPRD1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 NCBI chr 5:150,288,126...150,323,063
Ensembl chr 5:150,288,126...150,323,063
JBrowse link
G Oprk1 opioid receptor, kappa 1 multiple interactions
affects binding
EXP [Dextropropoxyphene binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Dextropropoxyphene binds to OPRK1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 NCBI chr 5:13,742,655...13,760,460
Ensembl chr 5:13,744,658...13,760,305
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
affects binding
EXP [Dextropropoxyphene binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Dextropropoxyphene binds to OPRM1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 NCBI chr 1:43,454,803...43,704,948
Ensembl chr 1:43,454,803...43,704,948
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Dextropropoxyphene inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
dicyclomine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Dicyclomine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
diphenylpyraline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hrh1 histamine receptor H 1 multiple interactions ISO diphenylpyraline binds to and results in increased activity of HRH1 protein; diphenylpyraline inhibits the reaction [Pyrilamine binds to HRH1 protein] CTD PMID:1912125 NCBI chr 4:146,374,596...146,458,148
Ensembl chr 4:146,455,332...146,457,074
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO diphenylpyraline results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
doxylamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Doxylamine results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO Doxylamine binds to and results in increased activity of NR1I3 protein alternative form CTD PMID:20869355 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
EPTC term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity EXP EPTC results in decreased activity of ACHE protein CTD PMID:14644616 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member decreases activity ISO EPTC metabolite results in decreased activity of ALDH2 protein CTD PMID:10513990 NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752
JBrowse link
G Alox15 arachidonate 15-lipoxygenase affects response to substance ISO ALOX15 gene SNP affects the susceptibility to EPTC CTD PMID:22919386 NCBI chr10:56,953,692...56,962,145
Ensembl chr10:56,953,691...56,962,161
JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit multiple interactions EXP EPTC results in decreased activity of [CHRNA3 protein binds to CHRNB2 protein]; EPTC results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 8:59,594,007...59,607,122
Ensembl chr 8:59,592,403...59,607,275
JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions EXP EPTC results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; EPTC results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 3:176,533,182...176,547,965
Ensembl chr 3:176,527,516...176,548,208
JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions EXP EPTC results in decreased activity of [CHRNA3 protein binds to CHRNB2 protein]; EPTC results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:14644616 NCBI chr 2:189,088,570...189,096,785
Ensembl chr 2:189,088,570...189,096,785
JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions EXP EPTC results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]; EPTC results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 8:59,610,489...59,629,073
Ensembl chr 8:59,609,693...59,629,133
JBrowse link
iron(III) nitrilotriacetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO ferric nitrilotriacetate inhibits the reaction [Asbestos, Crocidolite results in increased expression of ABCB1 protein]; ferric nitrilotriacetate inhibits the reaction [Razoxane results in increased expression of ABCB1 protein] CTD PMID:18385176 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression ISO ferric nitrilotriacetate results in increased expression of ABCC1 mRNA CTD PMID:18617210 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression ISO ferric nitrilotriacetate results in increased expression of ABCC2 mRNA CTD PMID:18617210 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 increases expression ISO ferric nitrilotriacetate results in increased expression of ABCC4 mRNA CTD PMID:18617210 NCBI chr15:103,695,415...103,927,980
Ensembl chr15:103,696,557...103,927,592
JBrowse link
G Anxa2 annexin A2 increases expression EXP ferric nitrilotriacetate results in increased expression of ANXA2 mRNA CTD PMID:10854235 NCBI chr 8:75,687,134...75,723,589
Ensembl chr 8:75,687,100...75,723,594
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP ferric nitrilotriacetate results in increased expression of BAX mRNA CTD PMID:23208426 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression EXP ferric nitrilotriacetate results in increased expression of BBC3 mRNA CTD PMID:23208426 NCBI chr 1:78,261,491...78,267,802 JBrowse link
G Bik BCL2-interacting killer increases expression EXP ferric nitrilotriacetate results in increased expression of BIK mRNA CTD PMID:23208426 NCBI chr 7:124,390,924...124,410,449
Ensembl chr 7:124,391,432...124,410,447
JBrowse link
G Cald1 caldesmon 1 increases expression EXP ferric nitrilotriacetate results in increased expression of CALD1 mRNA CTD PMID:10854235 NCBI chr 4:62,103,948...62,291,375
Ensembl chr 4:62,220,736...62,291,489
JBrowse link
G Canx calnexin increases expression EXP ferric nitrilotriacetate results in increased expression of CANX protein CTD PMID:16908007 NCBI chr10:35,800,942...35,833,939
Ensembl chr10:35,800,942...35,833,861
JBrowse link
G Casp12 caspase 12 increases expression EXP ferric nitrilotriacetate results in increased expression of CASP12 mRNA CTD PMID:23208426 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160
JBrowse link
G Casp3 caspase 3 multiple interactions EXP [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP3 protein; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP3 mRNA; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP3 protein]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP3 mRNA] CTD PMID:21907755 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions EXP [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP8 protein; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP8 mRNA; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP8 protein]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP8 mRNA] CTD PMID:21907755 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions EXP [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP9 protein; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP9 mRNA; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP9 protein]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP9 mRNA] CTD PMID:21907755 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cat catalase multiple interactions
decreases activity
EXP [Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of CAT protein; chrysin inhibits the reaction [ferric nitrilotriacetate results in decreased activity of CAT protein]; geraniol inhibits the reaction [ferric nitrilotriacetate results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of CAT protein]; Quercetin inhibits the reaction [ferric nitrilotriacetate results in decreased activity of CAT protein] CTD PMID:9667754, PMID:15198074, PMID:18684806, PMID:21907755, PMID:23194824, PMID:30098279 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Ccnd1 cyclin D1 increases expression EXP ferric nitrilotriacetate results in increased expression of CCND1 mRNA; ferric nitrilotriacetate results in increased expression of CCND1 protein CTD PMID:18055543 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cd44 CD44 molecule (Indian blood group) increases expression EXP ferric nitrilotriacetate results in increased expression of CD44 mRNA; ferric nitrilotriacetate results in increased expression of CD44 protein CTD PMID:18055543 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cd47 Cd47 molecule increases expression EXP ferric nitrilotriacetate results in increased expression of CD47 mRNA CTD PMID:9119739 NCBI chr11:53,511,485...53,575,754
Ensembl chr11:53,514,595...53,575,175
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression EXP ferric nitrilotriacetate results in increased expression of CDKN1A mRNA CTD PMID:23208426 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 decreases expression EXP ferric nitrilotriacetate results in decreased expression of CHRM1 mRNA CTD PMID:19490752 NCBI chr 1:224,869,087...224,885,101
Ensembl chr 1:224,882,439...224,884,205
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 decreases expression EXP ferric nitrilotriacetate results in decreased expression of CHRM2 mRNA CTD PMID:19490752 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression
multiple interactions
EXP ferric nitrilotriacetate results in increased expression of COL1A1 protein
ethylisopropylamiloride inhibits the reaction [ferric nitrilotriacetate results in increased expression of COL1A1 protein]
CTD PMID:11159895 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Cygb cytoglobin multiple interactions EXP CYGB protein inhibits the reaction [[ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TGFB1 mRNA]; CYGB protein inhibits the reaction [[ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TIMP1 mRNA]; CYGB protein results in decreased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid] CTD PMID:16581302 NCBI chr10:105,618,325...105,628,091
Ensembl chr10:105,618,326...105,628,091
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO [[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT18 protein; [[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT8 protein; [Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein; allyl sulfide inhibits the reaction [CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]]; CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]; Ditiocarb inhibits the reaction [CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]] CTD PMID:12086689, PMID:17034788, PMID:21352821 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO ferric nitrilotriacetate results in increased expression of FOS mRNA CTD PMID:10381381 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression EXP ferric nitrilotriacetate results in increased expression of FOSL1 mRNA; ferric nitrilotriacetate results in increased expression of FOSL1 protein CTD PMID:18055543 NCBI chr 1:220,826,560...220,835,066
Ensembl chr 1:220,826,560...220,835,066
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases activity EXP ferric nitrilotriacetate results in decreased activity of G6PD protein CTD PMID:9667754 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO ferric nitrilotriacetate results in increased expression of GCLC mRNA CTD PMID:18617210 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity
multiple interactions
EXP ferric nitrilotriacetate results in decreased activity of GSR protein
[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of GSR protein; Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of GSR protein]; Quercetin inhibits the reaction [ferric nitrilotriacetate results in decreased activity of GSR protein]
CTD PMID:9667754, PMID:15198074, PMID:30098279 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gtse1 G-2 and S-phase expressed 1 increases expression EXP ferric nitrilotriacetate results in increased expression of GTSE1 mRNA CTD PMID:23208426 NCBI chr 7:126,736,416...126,753,221
Ensembl chr 7:126,736,732...126,753,220
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP [Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased secretion of HAVCR1 protein; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of HAVCR1 mRNA; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of HAVCR1 protein; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of HAVCR1 mRNA]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of HAVCR1 protein]; Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased secretion of HAVCR1 protein] CTD PMID:21907755, PMID:30098279 NCBI chr10:31,813,819...31,860,934
Ensembl chr10:31,813,814...31,848,379
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO ferric nitrilotriacetate inhibits the reaction [Asbestos, Crocidolite results in increased activity of HIF1A protein]; ferric nitrilotriacetate inhibits the reaction [Razoxane results in increased activity of HIF1A protein] CTD PMID:18385176 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP
ISO
ferric nitrilotriacetate results in increased expression of HMOX1 mRNA CTD PMID:18617210, PMID:19490752 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 increases expression EXP ferric nitrilotriacetate results in increased expression of HSP90AA1 mRNA CTD PMID:10854235 NCBI chr 6:135,107,262...135,112,793
Ensembl chr 6:135,107,271...135,112,775
JBrowse link
G Il24 interleukin 24 increases expression EXP ferric nitrilotriacetate results in increased expression of IL24 mRNA CTD PMID:23208426 NCBI chr13:47,618,451...47,623,849
Ensembl chr13:47,618,452...47,623,849
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
ISO
EXP
ferric nitrilotriacetate results in increased expression of IL6 protein
ferric nitrilotriacetate results in increased expression of IL6 mRNA
[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of IL6 protein; chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of IL6 protein]
CTD PMID:15781289, PMID:19490752, PMID:23194824 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression EXP ferric nitrilotriacetate results in increased expression of JUN mRNA; ferric nitrilotriacetate results in increased expression of JUN protein CTD PMID:18055543 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Krt18 keratin 18 multiple interactions ISO [[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT18 protein CTD PMID:17034788 NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131
JBrowse link
G Krt8 keratin 8 multiple interactions ISO [[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT8 protein CTD PMID:17034788 NCBI chr 7:143,596,511...143,603,745
Ensembl chr 7:143,596,511...143,603,803
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression EXP ferric nitrilotriacetate results in increased expression of MCM3 mRNA CTD PMID:23208426 NCBI chr 9:26,914,057...26,932,201
Ensembl chr 9:26,914,057...26,932,201
JBrowse link
G Mt1 metallothionein 1 multiple interactions ISO [ferric nitrilotriacetate co-treated with Hydrogen Peroxide] inhibits the reaction [MT1 protein binds to Cadmium]; [ferric nitrilotriacetate co-treated with Hydrogen Peroxide] inhibits the reaction [MT1 protein binds to Zinc]; ferric nitrilotriacetate results in increased oxidation of [MT1 protein binds to Zinc] CTD PMID:22001350 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO [ferric nitrilotriacetate co-treated with Hydrogen Peroxide] inhibits the reaction [MT2 protein binds to Cadmium] CTD PMID:22001350 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Mt3 metallothionein 3 decreases response to substance ISO MT3 protein results in decreased susceptibility to ferric nitrilotriacetate CTD PMID:12383939 NCBI chr19:11,324,708...11,326,112
Ensembl chr19:11,324,698...11,326,139
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression EXP ferric nitrilotriacetate results in increased expression of MYC mRNA; ferric nitrilotriacetate results in increased expression of MYC protein CTD PMID:18055543 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects localization ISO ferric nitrilotriacetate affects the localization of NFE2L2 protein CTD PMID:18617210 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of NFKB1 mRNA; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of NFKB1 mRNA] CTD PMID:21907755 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression
ISO
EXP
ferric nitrilotriacetate inhibits the reaction [Doxorubicin results in increased expression of NOS2 mRNA]; ferric nitrilotriacetate inhibits the reaction [Doxorubicin results in increased expression of NOS2 protein]; ferric nitrilotriacetate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
ferric nitrilotriacetate results in increased expression of NOS2 protein
[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of NOS2 protein; chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of NOS2 protein]; chrysin inhibits the reaction [ferric nitrilotriacetate results in increased expression of NOS2 protein]; ferric nitrilotriacetate promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]; ferric nitrilotriacetate promotes the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]
CTD PMID:11461780, PMID:11746204, PMID:12490132, PMID:23194824 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO ferric nitrilotriacetate results in increased expression of NQO1 mRNA; ferric nitrilotriacetate results in increased expression of NQO1 protein CTD PMID:18617210 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions
increases activity
EXP [ferric nitrilotriacetate results in increased abundance of Hydroxyl Radical] which results in increased activity of ODC1 protein; Active Hexose Correlated Compound inhibits the reaction [[ferric nitrilotriacetate results in increased abundance of Hydroxyl Radical] which results in increased activity of ODC1 protein]; Vitamin E inhibits the reaction [ferric nitrilotriacetate results in increased activity of ODC1 protein] CTD PMID:9667754, PMID:14623030, PMID:15949125 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 increases expression EXP ferric nitrilotriacetate results in increased expression of PCK1 mRNA CTD PMID:16960379 NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP [Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PCNA protein; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of PCNA mRNA; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of PCNA protein; chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PCNA protein]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of PCNA mRNA]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of PCNA protein] CTD PMID:21907755, PMID:23194824 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
JBrowse link
G Phlda3 pleckstrin homology-like domain, family A, member 3 increases expression EXP ferric nitrilotriacetate results in increased expression of PHLDA3 mRNA CTD PMID:23208426 NCBI chr13:52,588,917...52,592,002
Ensembl chr13:52,588,917...52,592,001
JBrowse link
G Plau plasminogen activator, urokinase multiple interactions
increases expression
increases activity
ISO Deferoxamine inhibits the reaction [ferric nitrilotriacetate results in increased activity of PLAU mRNA]; Deferoxamine inhibits the reaction [ferric nitrilotriacetate results in increased expression of PLAU mRNA] CTD PMID:17571974 NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
JBrowse link
G Plk2 polo-like kinase 2 increases expression EXP ferric nitrilotriacetate results in increased expression of PLK2 mRNA CTD PMID:23208426 NCBI chr 2:41,911,143...41,916,901
Ensembl chr 2:41,911,131...41,916,901
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G Pola1 DNA polymerase alpha 1, catalytic subunit increases expression EXP ferric nitrilotriacetate results in increased expression of POLA1 mRNA CTD PMID:10854235 NCBI chr  X:62,382,604...62,698,830
Ensembl chr  X:62,382,608...62,698,830
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G Ppia peptidylprolyl isomerase A increases expression EXP ferric nitrilotriacetate results in increased expression of PPIA protein CTD PMID:16908007 NCBI chr14:86,673,775...86,677,443
Ensembl chr14:86,673,775...86,677,443
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G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
EXP [Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PTGS2 protein; chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PTGS2 protein]; chrysin inhibits the reaction [ferric nitrilotriacetate results in increased expression of PTGS2 protein]; Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PTGS2 protein] CTD PMID:23194824, PMID:30098279 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
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G Ptprb protein tyrosine phosphatase, receptor type, B decreases expression EXP ferric nitrilotriacetate results in decreased expression of PTPRB mRNA CTD PMID:10854235 NCBI chr 7:59,326,484...59,431,114
Ensembl chr 7:59,326,518...59,425,718
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G Ptprz1 protein tyrosine phosphatase, receptor type Z1 increases expression EXP ferric nitrilotriacetate results in increased expression of PTPRZ1 mRNA; ferric nitrilotriacetate results in increased expression of PTPRZ1 protein CTD PMID:18055543 NCBI chr 4:49,941,046...50,140,764
Ensembl chr 4:49,941,304...50,140,762
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP [Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased localization of RELA protein; chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased localization of RELA protein] CTD PMID:23194824 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rpl19 ribosomal protein L19 increases expression EXP ferric nitrilotriacetate results in increased expression of RPL19 mRNA CTD PMID:10854235 NCBI chr10:85,978,691...85,981,979
Ensembl chr10:85,978,691...85,981,979
JBrowse link
G Rprm reprimo, TP53 dependent G2 arrest mediator homolog increases expression EXP ferric nitrilotriacetate results in increased expression of RPRM mRNA CTD PMID:23208426 NCBI chr 3:39,595,301...39,596,718
Ensembl chr 3:39,595,301...39,596,718
JBrowse link
G Rps13 ribosomal protein S13 increases expression EXP ferric nitrilotriacetate results in increased expression of RPS13 mRNA CTD PMID:10854235 NCBI chr 1:185,328,902...185,331,332
Ensembl chr 3:4,341,249...4,341,771
JBrowse link
G Rps15 ribosomal protein S15 increases expression EXP ferric nitrilotriacetate results in increased expression of RPS15 mRNA CTD PMID:10854235 NCBI chr 7:12,282,134...12,283,573
Ensembl chr 7:12,282,109...12,283,608
JBrowse link
G Slc11a2 solute carrier family 11 member 2 decreases expression ISO ferric nitrilotriacetate results in decreased expression of SLC11A2 mRNA CTD PMID:11925462 NCBI chr 7:142,025,812...142,062,892
Ensembl chr 7:142,025,815...142,063,212
JBrowse link
G Slc40a1 solute carrier family 40 member 1 decreases expression ISO ferric nitrilotriacetate results in decreased expression of SLC40A1 mRNA CTD PMID:11925462 NCBI chr 9:52,819,451...52,830,461
Ensembl chr 9:52,894,365...52,912,293
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP ferric nitrilotriacetate inhibits the reaction [Dimethylnitrosamine results in decreased expression of SOD1 protein] CTD PMID:15842777 NCBI chr11:30,363,282...30,368,858
Ensembl chr11:30,363,280...30,368,862
JBrowse link
G Ssrp1 structure specific recognition protein 1 increases expression EXP ferric nitrilotriacetate results in increased expression of SSRP1 mRNA CTD PMID:8844983 NCBI chr 3:72,447,516...72,457,621
Ensembl chr 3:72,447,537...72,457,649
JBrowse link
G Tgfa transforming growth factor alpha increases expression EXP ferric nitrilotriacetate results in increased expression of TGFA mRNA; ferric nitrilotriacetate results in increased expression of TGFA protein CTD PMID:8340253 NCBI chr 4:117,961,877...118,045,923
Ensembl chr 4:117,962,319...118,046,344
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP [ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TGFB1 mRNA; CYGB protein inhibits the reaction [[ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TGFB1 mRNA] CTD PMID:16581302 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression EXP ferric nitrilotriacetate results in increased expression of TGFB2 mRNA CTD PMID:23208426