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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tertiary amine
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Accession:CHEBI:32876 term browser browse the term
Definition:A compound formally derived from ammonia by replacing three hydrogen atoms by hydrocarbyl groups.
Synonyms:exact_synonym: tertiary amines
 related_synonym: Formula=NR3;   R3N;   SMILES=[*]N([*])[*];   tertiaeres Amin
 alt_id: CHEBI:26879;   CHEBI:9458
 xref: KEGG:C02196


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(-)-lobeline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions ISO [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Lobeline inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Lobeline results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:14645658 PMID:18448488 NCBI chr 3:168,136,246...168,157,839 JBrowse link
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit affects response to substance
multiple interactions		 ISO CHRNA7 protein mutant form affects the susceptibility to Lobeline
Lobeline binds to and results in decreased activity of CHRNA7 protein; Lobeline binds to and results in increased activity of CHRNA7 protein mutant form		 CTD PMID:10082212 NCBI chr 1:126,123,425...126,249,181 JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions ISO [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Lobeline inhibits the reaction [epibatidine binds to [CHRNA4 protein binds to CHRNB2 protein]]; Lobeline results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:14645658 PMID:18448488 NCBI chr 2:175,181,402...175,189,619 JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Lobeline results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:11,719,357...11,751,424 JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; Lobeline inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK1 protein] CTD PMID:18448488 PMID:20106947 NCBI chr11:97,462,025...97,529,193 JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; Lobeline inhibits the reaction [Nicotine results in decreased phosphorylation of MAPK3 protein] CTD PMID:18448488 PMID:20106947 NCBI chr 1:190,797,189...190,803,411 JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO [Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]; Lobeline inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein] CTD PMID:18448488 PMID:20106947 NCBI chr10:86,311,528...86,363,513 JBrowse link
(-)-selegiline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO [Clorgyline co-treated with Selegiline] inhibits the reaction [Norepinephrine results in increased expression of ACTA2 mRNA] CTD PMID:34609854 NCBI chr 1:241,159,723...241,172,503 JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions ISO Selegiline inhibits the reaction [1-Methyl-4-phenylpyridinium affects the localization of AIFM1 protein]; Selegiline inhibits the reaction [Oxidopamine affects the localization of AIFM1 protein]; Selegiline inhibits the reaction [Rotenone affects the localization of AIFM1 protein] CTD PMID:12880480 NCBI chr  X:132,528,107...132,567,237 JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation		 EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Selegiline co-treated with 1-Methyl-4-phenylpyridinium] results in increased phosphorylation of AKT1 protein]; [Selegiline co-treated with 1-Methyl-4-phenylpyridinium] results in increased phosphorylation of AKT1 protein
Selegiline results in increased phosphorylation of AKT1 protein		 CTD PMID:22019741 NCBI chr 6:137,534,810...137,555,131 JBrowse link
G Bach1 BTB domain and CNC homolog 1 multiple interactions ISO Selegiline inhibits the reaction [Smoke analog affects the localization of BACH1 protein] CTD PMID:28108387 NCBI chr11:40,425,721...40,461,118 JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Selegiline inhibits the reaction [linsidomine results in increased expression of BAX protein] CTD PMID:12880480 NCBI chr 1:105,076,472...105,081,906 JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO Selegiline inhibits the reaction [linsidomine results in decreased expression of BCL2 protein] CTD PMID:12880480 NCBI chr13:23,204,464...23,366,900 JBrowse link
G Casp3 caspase 3 multiple interactions ISO Selegiline inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 mRNA]; Selegiline inhibits the reaction [linsidomine results in increased expression of CASP3 mRNA]; Selegiline inhibits the reaction [linsidomine results in increased expression of CASP3 protein]
Selegiline promotes the reaction [Hydroxyurea results in increased cleavage of CASP3 protein]		 CTD PMID:12880480 PMID:14724376 PMID:23696560 NCBI chr16:52,395,539...52,413,794 JBrowse link
G Cat catalase multiple interactions EXP
ISO		 Selegiline promotes the reaction [Rotenone results in increased activity of CAT protein]
Selegiline inhibits the reaction [Smoke analog results in decreased activity of CAT protein]		 CTD PMID:16490285 PMID:28108387 NCBI chr 3:110,297,340...110,329,526 JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO [Clorgyline co-treated with Selegiline] inhibits the reaction [Norepinephrine results in increased expression of COL1A1 mRNA] CTD PMID:34609854 NCBI chr10:80,380,458...80,397,461 JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions ISO [Clorgyline co-treated with Selegiline] inhibits the reaction [Norepinephrine results in increased expression of COL3A1 mRNA] CTD PMID:34609854 NCBI chr 9:54,866,646...54,902,578 JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO Selegiline inhibits the reaction [linsidomine affects the localization of CYCS protein] CTD PMID:12880480 NCBI chr 4:80,982,667...80,984,767 JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects metabolic processing ISO CYP1A2 protein affects the metabolism of Selegiline CTD PMID:16198659 NCBI chr 8:66,971,261...66,978,149 JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
decreases activity		 ISO Selegiline inhibits the reaction [CYP2B6 protein results in increased hydroxylation of Bupropion]
Selegiline results in decreased activity of CYP2B6 protein		 CTD PMID:25656918 NCBI chr 1:90,780,468...90,859,852 JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Selegiline inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of FOS mRNA] CTD PMID:14724376 NCBI chr 6:110,852,188...110,855,054 JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO
EXP		 Selegiline inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of GAPDH mRNA]
Selegiline inhibits the reaction [Paraquat affects the localization of GAPDH protein]
Selegiline inhibits the reaction [Hydroxyurea affects the localization of GAPDH protein]		 CTD PMID:14724376 PMID:20478973 PMID:23696560 NCBI chr 4:157,962,312...157,967,158 JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO Selegiline inhibits the reaction [Smoke analog results in increased expression of HMOX1 protein] CTD PMID:28108387 NCBI chr19:13,452,365...13,479,823 JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression		 ISO Selegiline inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of JUN mRNA]
Selegiline results in increased expression of JUN protein		 CTD PMID:14724376 PMID:16099847 NCBI chr 5:115,009,900...115,012,993 JBrowse link
G Maoa monoamine oxidase A decreases activity ISO Selegiline results in decreased activity of MAOA protein CTD PMID:31323226 NCBI chr  X:8,615,239...8,681,372 JBrowse link
G Maob monoamine oxidase B affects binding
decreases activity
multiple interactions		 ISO
EXP		 Selegiline binds to MAOB protein
Selegiline results in decreased activity of MAOB protein
[Selegiline results in decreased activity of MAOB protein] which results in decreased abundance of 3,4-Dihydroxyphenylacetic Acid; [Selegiline results in decreased activity of MAOB protein] which results in decreased abundance of Homovanillic Acid; [Selegiline results in decreased activity of MAOB protein] which results in increased abundance of Dopamine
[Selegiline results in decreased activity of MAOB protein] which results in increased susceptibility to Methamphetamine; zonisamide inhibits the reaction [Selegiline binds to MAOB protein]
Selegiline inhibits the reaction [MAOB protein results in decreased amination of Dopamine]; Selegiline inhibits the reaction [MAOB protein results in increased degradation of Dopamine]; Selegiline inhibits the reaction [Smoke analog results in increased activity of MAOB protein]		 CTD PMID:1905457 PMID:15178694 PMID:15545290 PMID:16012872 PMID:16252076 More... NCBI chr  X:8,490,405...8,594,065 JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO
EXP		 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Selegiline results in increased phosphorylation of MAPK1 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Selegiline co-treated with 1-Methyl-4-phenylpyridinium] results in increased phosphorylation of MAPK1 protein]; [Selegiline co-treated with 1-Methyl-4-phenylpyridinium] results in increased phosphorylation of MAPK1 protein		 CTD PMID:16099847 PMID:22019741 NCBI chr11:97,462,025...97,529,193 JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO
EXP		 N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Selegiline results in increased phosphorylation of MAPK3 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[Selegiline co-treated with 1-Methyl-4-phenylpyridinium] results in increased phosphorylation of MAPK3 protein]; [Selegiline co-treated with 1-Methyl-4-phenylpyridinium] results in increased phosphorylation of MAPK3 protein		 CTD PMID:16099847 PMID:22019741 NCBI chr 1:190,797,189...190,803,411 JBrowse link
G Mt1 metallothionein 1 multiple interactions ISO Selegiline inhibits the reaction [linsidomine results in increased expression of MT1 protein] CTD PMID:12880480 NCBI chr19:10,831,959...10,832,975 JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases phosphorylation
multiple interactions		 ISO Selegiline results in increased phosphorylation of MYC protein
MYC protein affects the reaction [Selegiline results in increased expression of TXN]		 CTD PMID:16099847 NCBI chr 7:95,483,105...95,488,031 JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases localization		 EXP
ISO		 NFE2L2 mutant form inhibits the reaction [Selegiline inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased activity of NQO1 protein]]; NFE2L2 mutant form inhibits the reaction [Selegiline results in increased activity of NQO1 protein]; Selegiline inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased localization of NFE2L2 protein]
Selegiline inhibits the reaction [Smoke analog affects the localization of NFE2L2 protein]
Selegiline results in increased localization of NFE2L2 protein		 CTD PMID:22019741 PMID:28108387 NCBI chr 3:81,001,529...81,031,165 JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases activity		 EXP
ISO		 NFE2L2 mutant form inhibits the reaction [Selegiline inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased activity of NQO1 protein]]; NFE2L2 mutant form inhibits the reaction [Selegiline results in increased activity of NQO1 protein]; Selegiline inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased activity of NQO1 protein]
Selegiline inhibits the reaction [Smoke analog results in increased expression of NQO1 protein]		 CTD PMID:22019741 PMID:28108387 NCBI chr19:52,205,374...52,220,267 JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Selegiline inhibits the reaction [linsidomine results in decreased expression of PARP1 protein] CTD PMID:12880480 NCBI chr13:94,839,484...94,871,295 JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions ISO Selegiline inhibits the reaction [linsidomine results in increased expression of PRKN protein] CTD PMID:12880480 NCBI chr 1:51,236,410...52,430,242 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Selegiline inhibits the reaction [Smoke analog affects the localization of RELA protein] CTD PMID:28108387 NCBI chr 1:212,354,336...212,364,815 JBrowse link
G Siah1 siah E3 ubiquitin protein ligase 1 multiple interactions EXP Selegiline inhibits the reaction [Paraquat affects the localization of SIAH1A protein] CTD PMID:20478973 NCBI chr19:36,552,165...36,575,773 JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Selegiline inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019 JBrowse link
G Snca synuclein alpha multiple interactions ISO Selegiline inhibits the reaction [1,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline results in increased expression of SNCA protein]; Selegiline inhibits the reaction [linsidomine results in increased expression of SNCA protein] CTD PMID:12880480 PMID:15114628 NCBI chr 4:91,026,474...91,127,444 JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO [Clorgyline co-treated with Selegiline] inhibits the reaction [Norepinephrine results in increased phosphorylation of STAT3 protein] CTD PMID:34609854 NCBI chr10:86,311,528...86,363,513 JBrowse link
G Th tyrosine hydroxylase multiple interactions
decreases expression		 EXP Selegiline inhibits the reaction [Rotenone results in decreased expression of TH protein]
Selegiline results in decreased expression of TH mRNA		 CTD PMID:11862330 PMID:16490285 NCBI chr 1:207,500,959...207,508,276 JBrowse link
G Txn1 thioredoxin 1 multiple interactions
increases expression
affects response to substance		 ISO Dinitrochlorobenzene inhibits the reaction [Selegiline results in increased expression of TXN]; Dinitrochlorobenzene inhibits the reaction [TXN protein affects the susceptibility to Selegiline]; MYC protein affects the reaction [Selegiline results in increased expression of TXN]
Selegiline results in increased expression of TXN protein		 CTD PMID:16099847 NCBI chr 5:77,507,455...77,519,685 JBrowse link
almotriptan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases methylation
increases metabolic processing
increases hydroxylation		 ISO CYP1A1 protein results in decreased methylation of almotriptan
CYP1A1 protein results in increased metabolism of almotriptan
CYP1A1 protein results in increased hydroxylation of almotriptan		 CTD PMID:12642466 NCBI chr 8:66,991,940...66,998,014 JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases methylation ISO CYP1A2 protein results in decreased methylation of almotriptan CTD PMID:12642466 NCBI chr 8:66,971,261...66,978,149 JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 decreases methylation ISO CYP2C19 protein results in decreased methylation of almotriptan CTD PMID:12642466 NCBI chr 1:247,879,058...247,916,804 JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases methylation ISO CYP2C8 protein results in decreased methylation of almotriptan CTD PMID:12642466
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases methylation
increases hydroxylation		 ISO CYP2D6 protein results in decreased methylation of almotriptan
CYP2D6 protein results in increased hydroxylation of almotriptan		 CTD PMID:12642466 NCBI chr 7:115,762,662...115,771,832 JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases hydroxylation
decreases methylation		 ISO CYP3A4 protein results in increased hydroxylation of almotriptan
CYP3A4 protein results in decreased methylation of almotriptan		 CTD PMID:12642466 NCBI chr12:14,321,771...14,343,886 JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 increases oxidation ISO FMO3 protein results in increased oxidation of almotriptan CTD PMID:12642466 NCBI chr13:75,309,367...75,334,915 JBrowse link
G Htr1b 5-hydroxytryptamine receptor 1B multiple interactions ISO HTR1B affects the reaction [almotriptan inhibits the reaction [Colforsin results in increased abundance of Cyclic AMP]] CTD PMID:11134654 NCBI chr 8:91,395,405...91,414,815 JBrowse link
G Maoa monoamine oxidase A increases metabolic processing ISO MAOA protein results in increased metabolism of almotriptan CTD PMID:12642466 NCBI chr  X:8,615,239...8,681,372 JBrowse link
alverine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Htr1a 5-hydroxytryptamine receptor 1A affects binding EXP alverine binds to HTR1A protein CTD PMID:11697552 NCBI chr 2:38,427,169...38,431,733 JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO alverine results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:11,719,357...11,751,424 JBrowse link
amitriptyline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aadat aminoadipate aminotransferase affects expression EXP Amitriptyline affects the expression of AADAT mRNA CTD PMID:18355885 NCBI chr16:29,509,392...29,544,332 JBrowse link
G Abat 4-aminobutyrate aminotransferase decreases expression EXP Amitriptyline results in decreased expression of ABAT mRNA CTD PMID:21820738 NCBI chr10:7,503,351...7,599,474 JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression EXP Amitriptyline results in decreased expression of ABCB11 mRNA CTD PMID:27765674 NCBI chr 3:74,424,620...74,520,646 JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects transport
increases transport
affects expression		 ISO
EXP		 ABCB1A protein affects the transport of Amitriptyline
ABCB1A protein results in increased transport of Amitriptyline; ABCB1A protein results in increased transport of Amitriptyline metabolite
Amitriptyline affects the expression of ABCB1 mRNA		 CTD PMID:10700657 PMID:12082591 PMID:18355885 NCBI chr 4:26,312,403...26,488,456 JBrowse link
G Abcd2 ATP binding cassette subfamily D member 2 decreases expression EXP Amitriptyline results in decreased expression of ABCD2 mRNA CTD PMID:22341215 NCBI chr 7:122,263,034...122,311,642 JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 decreases expression EXP Amitriptyline results in decreased expression of ABCG5 mRNA CTD PMID:27765674 NCBI chr 6:9,965,118...9,990,563 JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 decreases expression EXP Amitriptyline results in decreased expression of ABCG8 mRNA CTD PMID:27765674 NCBI chr 6:9,945,629...9,964,912 JBrowse link
G Ace2 angiotensin converting enzyme 2 increases expression ISO Amitriptyline results in increased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:30,293,597...30,340,961 JBrowse link
G Ache acetylcholinesterase decreases expression
increases activity		 EXP
ISO		 Amitriptyline results in decreased expression of ACHE mRNA
Amitriptyline results in increased activity of ACHE protein		 CTD PMID:21820738 PMID:29614332 NCBI chr12:25,042,882...25,050,608 JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 affects expression EXP Amitriptyline affects the expression of ALDH1A1 mRNA CTD PMID:18355885 NCBI chr 1:218,000,470...218,152,962 JBrowse link
G Ankrd1 ankyrin repeat domain 1 increases expression EXP Amitriptyline results in increased expression of ANKRD1 mRNA CTD PMID:22341215 NCBI chr 1:233,815,851...233,834,891 JBrowse link
G Ano3 anoctamin 3 decreases expression EXP Amitriptyline results in decreased expression of ANO3 mRNA CTD PMID:22341215 NCBI chr 3:97,235,671...97,550,090 JBrowse link
G Ap1s1 adaptor related protein complex 1 subunit sigma 1 decreases expression ISO Amitriptyline results in decreased expression of AP1S1 mRNA CTD PMID:17175557 PMID:17567588 NCBI chr12:19,625,267...19,635,792 JBrowse link
G Apoa4 apolipoprotein A4 affects expression EXP Amitriptyline affects the expression of APOA4 mRNA CTD PMID:18355885 NCBI chr 8:55,435,779...55,438,160 JBrowse link
G Arg1 arginase 1 increases expression EXP Amitriptyline results in increased expression of ARG1 mRNA CTD PMID:22341215 NCBI chr 1:22,295,093...22,307,720 JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 increases expression ISO Amitriptyline results in increased expression of ASAH1 mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr16:57,669,927...57,701,349 JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Amitriptyline results in increased expression of ASNS mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr 4:36,752,061...36,769,970 JBrowse link
G Atf3 activating transcription factor 3 increases expression EXP Amitriptyline results in increased expression of ATF3 mRNA CTD PMID:22341215 NCBI chr13:105,274,103...105,331,653 JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Amitriptyline inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein] CTD PMID:19135049 NCBI chr 1:105,076,472...105,081,906 JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Amitriptyline inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein] CTD PMID:19135049 NCBI chr13:23,204,464...23,366,900 JBrowse link
G Bhmt betaine-homocysteine S-methyltransferase affects expression EXP Amitriptyline affects the expression of BHMT mRNA CTD PMID:18355885 NCBI chr 2:26,594,852...26,614,429 JBrowse link
G C1qa complement C1q A chain increases expression EXP Amitriptyline results in increased expression of C1QA mRNA CTD PMID:22341215 NCBI chr 5:154,417,086...154,419,933 JBrowse link
G C1qc complement C1q C chain increases expression EXP Amitriptyline results in increased expression of C1QC mRNA CTD PMID:22341215 NCBI chr 5:154,410,845...154,414,208 JBrowse link
G Cacna2d1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 increases expression EXP Amitriptyline results in increased expression of CACNA2D1 mRNA CTD PMID:22341215 NCBI chr 4:19,902,324...20,330,287 JBrowse link
G Casp1 caspase 1 multiple interactions ISO Amitriptyline inhibits the reaction [7-ketocholesterol affects the localization of CASP1 protein]; Amitriptyline inhibits the reaction [7-ketocholesterol results in increased activity of CASP1 protein]; Amitriptyline inhibits the reaction [Cholesterol analog affects the localization of CASP1 protein]; Amitriptyline inhibits the reaction [Cholesterol analog results in increased activity of CASP1 protein] CTD PMID:28633109 NCBI chr 8:10,746,338...10,882,295 JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
increases activity		 EXP Amitriptyline inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased activity of CASP3 protein]
Amitriptyline results in increased expression of CASP3 mRNA
Amitriptyline results in increased activity of CASP3 protein		 CTD PMID:16717317 PMID:19135049 PMID:19815060 NCBI chr16:52,395,539...52,413,794 JBrowse link
G Casr calcium-sensing receptor decreases expression EXP Amitriptyline results in decreased expression of CASR mRNA CTD PMID:22341215 NCBI chr11:77,738,398...77,813,639 JBrowse link
G Cat catalase decreases expression ISO Amitriptyline results in decreased expression of CAT protein CTD PMID:1937386 NCBI chr 3:110,297,340...110,329,526 JBrowse link
G Cd74 CD74 molecule increases expression EXP Amitriptyline results in increased expression of CD74 mRNA CTD PMID:22341215 NCBI chr18:54,256,757...54,266,003 JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C affects expression EXP Amitriptyline affects the expression of CDKN2C mRNA CTD PMID:18355885 NCBI chr 5:129,639,736...129,645,564 JBrowse link
G Ces2h carboxylesterase 2H affects expression EXP Amitriptyline affects the expression of CES2 mRNA CTD PMID:18355885 NCBI chr19:32,974,242...32,988,842 JBrowse link
G Chat choline O-acetyltransferase increases expression EXP Amitriptyline results in increased expression of CHAT mRNA CTD PMID:21820738 NCBI chr16:7,657,362...7,717,093 JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit decreases expression EXP Amitriptyline results in decreased expression of CHRNA3 mRNA CTD PMID:22341215 NCBI chr 8:55,401,668...55,415,165 JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit decreases expression
increases response to substance		 EXP
ISO		 Amitriptyline results in decreased expression of CHRNB2 mRNA
CHRNB2 protein results in increased susceptibility to Amitriptyline		 CTD PMID:21820738 PMID:21905669 NCBI chr 2:175,181,402...175,189,619 JBrowse link
G Cmtm6 CKLF-like MARVEL transmembrane domain containing 6 affects expression EXP Amitriptyline affects the expression of CMTM6 mRNA CTD PMID:18355885 NCBI chr 8:114,422,934...114,441,034 JBrowse link
G Cpne4 copine 4 decreases expression EXP Amitriptyline results in decreased expression of CPNE4 mRNA CTD PMID:22341215 NCBI chr 8:105,177,376...105,653,075 JBrowse link
G Cpped1 calcineurin-like phosphoesterase domain containing 1 affects expression EXP Amitriptyline affects the expression of CPPED1 mRNA CTD PMID:18355885 NCBI chr10:3,701,522...3,821,050 JBrowse link
G Crem cAMP responsive element modulator affects expression EXP Amitriptyline affects the expression of CREM mRNA CTD PMID:18355885 NCBI chr17:58,932,011...59,001,160 JBrowse link
G Csrp3 cysteine and glycine rich protein 3 increases expression EXP Amitriptyline results in increased expression of CSRP3 mRNA CTD PMID:22341215 NCBI chr 1:98,528,067...98,546,647 JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions ISO Amitriptyline inhibits the reaction [7-ketocholesterol affects the localization of CYBB protein]; Amitriptyline inhibits the reaction [7-ketocholesterol analog affects the localization of CYBB protein] CTD PMID:28633109 NCBI chr  X:16,030,596...16,065,065 JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing
multiple interactions		 ISO Amitriptyline results in increased metabolism of CYP1A2 protein; CYP1A2 protein results in increased metabolism of Amitriptyline
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Amitriptyline		 CTD PMID:18359012 PMID:23397584 PMID:27320963 NCBI chr 8:66,971,261...66,978,149 JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 affects expression EXP Amitriptyline affects the expression of CYP2A1 mRNA CTD PMID:18355885 NCBI chr 1:82,231,611...82,244,887 JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression EXP Amitriptyline results in increased expression of CYP2B1 mRNA CTD PMID:10945841 NCBI chr 1:90,646,098...90,669,762 JBrowse link
G Cyp2b15 cytochrome P450, family 2, subfamily b, polypeptide 15 affects expression EXP Amitriptyline affects the expression of CYP2B15 mRNA CTD PMID:18355885 NCBI chr 1:82,094,188...82,106,492 JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP Amitriptyline results in increased expression of CYP2B2 mRNA CTD PMID:10945841 NCBI chr 1:90,722,243...90,736,272 JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases metabolic processing ISO CYP2B6 protein results in increased metabolism of Amitriptyline CTD PMID:27320963 NCBI chr 1:90,780,468...90,859,852 JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 multiple interactions
increases metabolic processing		 ISO [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Amitriptyline
CYP2C19 protein results in increased metabolism of Amitriptyline		 CTD PMID:23397584 PMID:27320963 NCBI chr 1:247,879,058...247,916,804 JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity
multiple interactions
increases metabolic processing		 ISO Amitriptyline results in decreased activity of CYP2D6 protein
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Amitriptyline
Amitriptyline results in increased metabolism of CYP2D6 protein; CYP2D6 protein results in increased metabolism of Amitriptyline		 CTD PMID:16044105 PMID:18359012 PMID:18359183 PMID:23397584 PMID:27320963 NCBI chr 7:115,762,662...115,771,832 JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases metabolic processing
multiple interactions		 ISO Amitriptyline results in increased metabolism of CYP3A4 protein
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Amitriptyline		 CTD PMID:18359012 PMID:23397584 NCBI chr12:14,321,771...14,343,886 JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression
affects expression		 EXP Amitriptyline results in increased expression of CYP3A23-3A1 mRNA
Amitriptyline affects the expression of CYP3A23-3A1 mRNA		 CTD PMID:10945841 PMID:18355885 NCBI chr12:14,369,950...14,398,803 JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases metabolic processing ISO Amitriptyline results in increased metabolism of CYP3A5 protein CTD PMID:18359012 NCBI chr12:21,919,955...21,960,160 JBrowse link
G Cyp4f4 cytochrome P450, family 4, subfamily f, polypeptide 4 affects expression EXP Amitriptyline affects the expression of CYP4F2 mRNA CTD PMID:18355885 NCBI chr 7:11,717,208...11,733,507 JBrowse link
G Dcaf8 DDB1 and CUL4 associated factor 8 affects expression EXP Amitriptyline affects the expression of DCAF8 mRNA CTD PMID:18355885 NCBI chr13:87,141,940...87,199,859 JBrowse link
G Depp1 DEPP autophagy regulator 1 increases expression ISO Amitriptyline results in increased expression of DEPP1 mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr 4:149,910,794...149,913,013 JBrowse link
G Des desmin multiple interactions ISO Amitriptyline inhibits the reaction [Homocysteine results in increased expression of DES protein] CTD PMID:23024785 NCBI chr 9:84,299,626...84,307,344 JBrowse link
G Dnmt1 DNA methyltransferase 1 decreases activity EXP Amitriptyline results in decreased activity of DNMT1 protein
Amitriptyline decreases activity of Dnmt1 protein in astrocyte nucleus		 CTD
RGD		 PMID:19924110 PMID:22880885 RGD:9588218 NCBI chr 8:19,440,611...19,486,659 JBrowse link
G Drd1 dopamine receptor D1 increases expression EXP Amitriptyline results in increased expression of DRD1 mRNA CTD PMID:16499906 NCBI chr17:10,545,488...10,550,029 JBrowse link
G Drd3 dopamine receptor D3 increases expression EXP Amitriptyline results in increased expression of DRD3 mRNA CTD PMID:21820738 NCBI chr11:70,385,586...70,437,793 JBrowse link
G Ecel1 endothelin converting enzyme-like 1 increases expression EXP Amitriptyline results in increased expression of ECEL1 mRNA CTD PMID:22341215 NCBI chr 9:95,267,417...95,276,508 JBrowse link
G Eif4b eukaryotic translation initiation factor 4B affects expression EXP Amitriptyline affects the expression of EIF4B mRNA CTD PMID:18355885 NCBI chr 7:135,085,259...135,107,054 JBrowse link
G Ephx1 epoxide hydrolase 1 affects expression EXP Amitriptyline affects the expression of EPHX1 mRNA CTD PMID:18355885 NCBI chr13:95,246,079...95,275,852 JBrowse link
G Erp29 endoplasmic reticulum protein 29 affects expression EXP Amitriptyline affects the expression of ERP29 mRNA CTD PMID:18355885 NCBI chr12:40,750,177...40,756,607 JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO Amitriptyline results in increased expression of FABP1 mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr 4:104,744,302...104,753,119 JBrowse link
G Flrt3 fibronectin leucine rich transmembrane protein 3 increases expression EXP Amitriptyline results in increased expression of FLRT3 mRNA CTD PMID:22341215 NCBI chr 3:127,994,491...128,008,137 JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 increases metabolic processing ISO FMO3 protein results in increased metabolism of Amitriptyline CTD PMID:27320963 NCBI chr13:75,309,367...75,334,915 JBrowse link
G Fndc4 fibronectin type III domain containing 4 increases expression ISO Amitriptyline results in increased expression of FNDC4 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 6:25,077,155...25,080,812 JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 increases expression
decreases expression		 EXP Amitriptyline results in increased expression of GABRA1 mRNA
Amitriptyline results in decreased expression of GABRA1 mRNA		 CTD PMID:21820738 PMID:22341215 NCBI chr10:27,096,731...27,152,563 JBrowse link
G Gabra2 gamma-aminobutyric acid type A receptor subunit alpha 2 increases expression EXP Amitriptyline results in increased expression of GABRA2 mRNA CTD PMID:21820738 NCBI chr14:37,451,218...37,587,458 JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 increases expression EXP Amitriptyline results in increased expression of GABRA4 mRNA CTD PMID:21820738 NCBI chr14:36,590,782...36,667,724 JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 increases expression EXP Amitriptyline results in increased expression of GABRB3 mRNA CTD PMID:21820738 NCBI chr 1:117,602,772...117,838,230 JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression EXP Amitriptyline results in increased expression of GADD45A mRNA CTD PMID:22341215 NCBI chr 4:97,484,497...97,486,799 JBrowse link
G Gal galanin and GMAP prepropeptide increases expression EXP Amitriptyline results in increased expression of GAL mRNA CTD PMID:22341215 NCBI chr 1:210,079,709...210,084,572 JBrowse link
G Gckr glucokinase regulator affects expression EXP Amitriptyline affects the expression of GCKR mRNA CTD PMID:18355885 NCBI chr 6:25,044,592...25,075,834 JBrowse link
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 increases expression ISO Amitriptyline results in increased expression of GDPD3 mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr 1:181,373,505...181,383,063 JBrowse link
G Gfap glial fibrillary acidic protein increases expression EXP Amitriptyline results in increased expression of GFAP mRNA CTD PMID:22954530 NCBI chr10:88,352,987...88,361,661 JBrowse link
G Gls2 glutaminase 2 affects expression EXP Amitriptyline affects the expression of GLS2 mRNA CTD PMID:18355885 NCBI chr 7:617,252...633,424 JBrowse link
G Got2 glutamic-oxaloacetic transaminase 2 affects expression EXP Amitriptyline affects the expression of GOT2 mRNA CTD PMID:18355885 NCBI chr19:9,180,428...9,206,113 JBrowse link
G Grb14 growth factor receptor bound protein 14 affects expression EXP Amitriptyline affects the expression of GRB14 mRNA CTD PMID:18355885 NCBI chr 3:49,568,210...49,683,805 JBrowse link
G Grik1 glutamate ionotropic receptor kainate type subunit 1 decreases expression EXP Amitriptyline results in decreased expression of GRIK1 mRNA CTD PMID:22341215 NCBI chr11:27,169,739...27,571,131 JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases activity ISO Amitriptyline results in decreased activity of GSTP1 protein CTD PMID:15094841 NCBI chr 1:210,767,237...210,770,242 JBrowse link
G Hal histidine ammonia lyase affects expression EXP Amitriptyline affects the expression of HAL mRNA CTD PMID:18355885 NCBI chr 7:28,007,449...28,037,701 JBrowse link
G Hmgb2 high mobility group box 2 affects expression EXP Amitriptyline affects the expression of HMGB2 mRNA CTD PMID:18355885 NCBI chr16:37,721,374...37,723,950 JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO Amitriptyline results in increased expression of HMGCS1 mRNA CTD PMID:16324787 NCBI chr 2:53,379,457...53,399,807 JBrowse link
G Hoxd1 homeo box D1 decreases expression EXP Amitriptyline results in decreased expression of HOXD1 mRNA CTD PMID:22341215 NCBI chr 3:59,665,629...59,667,769 JBrowse link
G Hpn hepsin increases expression ISO Amitriptyline results in increased expression of HPN mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr 1:86,337,085...86,352,785 JBrowse link
G Hpse heparanase decreases expression EXP Amitriptyline results in decreased expression of HPSE mRNA CTD PMID:22341215 NCBI chr14:9,200,971...9,241,377 JBrowse link
G Hs3st2 heparan sulfate-glucosamine 3-sulfotransferase 2 decreases expression EXP Amitriptyline results in decreased expression of HS3ST2 mRNA CTD PMID:22341215 NCBI chr 1:175,956,161...176,077,400 JBrowse link
G Htr1a 5-hydroxytryptamine receptor 1A increases expression EXP Amitriptyline results in increased expression of HTR1A protein CTD PMID:1589591 NCBI chr 2:38,427,169...38,431,733 JBrowse link
G Htr1d 5-hydroxytryptamine receptor 1D decreases expression EXP Amitriptyline results in decreased expression of HTR1D mRNA CTD PMID:22341215 NCBI chr 5:153,939,735...153,960,012 JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C affects binding ISO Amitriptyline binds to HTR2C protein CTD PMID:18083778 NCBI chr  X:115,453,190...115,682,325 JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Amitriptyline inhibits the reaction [7-ketocholesterol results in increased expression of IL1B protein]; Amitriptyline inhibits the reaction [Cholesterol analog results in increased expression of IL1B protein] CTD PMID:28633109 NCBI chr 3:137,030,200...137,036,581 JBrowse link
G Il33 interleukin 33 affects expression EXP Amitriptyline affects the expression of IL33 mRNA CTD PMID:18355885 NCBI chr 1:227,701,964...227,736,374 JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Amitriptyline results in increased expression of INHBE mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr 7:65,061,531...65,064,519 JBrowse link
G Itgb6 integrin subunit beta 6 decreases expression EXP Amitriptyline results in decreased expression of ITGB6 mRNA CTD PMID:22341215 NCBI chr 3:45,046,295...45,170,532 JBrowse link
G Kcna4 potassium voltage-gated channel subfamily A member 4 decreases expression EXP Amitriptyline results in decreased expression of KCNA4 mRNA CTD PMID:22341215 NCBI chr 3:93,756,399...93,778,004 JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions ISO Amitriptyline inhibits the reaction [KCNH2 protein results in increased transport of Thallium] CTD PMID:19583963 PMID:21158687 NCBI chr 4:11,719,357...11,751,424 JBrowse link
G Kcnn2 potassium calcium-activated channel subfamily N member 2 decreases activity EXP Amitriptyline results in decreased activity of KCNN2 protein CTD PMID:10915830 NCBI chr18:40,004,693...40,445,043 JBrowse link
G Kcns1 potassium voltage-gated channel, modifier subfamily S, member 1 decreases expression EXP Amitriptyline results in decreased expression of KCNS1 mRNA CTD PMID:22341215 NCBI chr 3:152,835,642...152,843,032 JBrowse link
G Kcns3 potassium voltage-gated channel, modifier subfamily S, member 3 decreases expression EXP Amitriptyline results in decreased expression of KCNS3 mRNA CTD PMID:22341215 NCBI chr 6:33,808,314...33,865,018 JBrowse link
G Lox lysyl oxidase affects expression EXP Amitriptyline affects the expression of LOX mRNA CTD PMID:18355885 NCBI chr18:45,964,544...45,977,431 JBrowse link
G Lss lanosterol synthase increases expression ISO Amitriptyline results in increased expression of LSS mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr20:12,090,641...12,118,230 JBrowse link
G Macroh2a1 macroH2A.1 histone affects expression EXP Amitriptyline affects the expression of MACROH2A1 mRNA CTD PMID:18355885 NCBI chr17:8,479,331...8,542,071 JBrowse link
G Manba mannosidase beta affects expression EXP Amitriptyline affects the expression of MANBA mRNA CTD PMID:18355885 NCBI chr 2:223,910,432...224,002,988 JBrowse link
G Maoa monoamine oxidase A affects expression EXP Amitriptyline affects the expression of MAOA mRNA CTD PMID:21820738 NCBI chr  X:8,615,239...8,681,372 JBrowse link
G Mlx MAX dimerization protein MLX affects expression EXP Amitriptyline affects the expression of MLX mRNA CTD PMID:18355885 NCBI chr10:86,519,517...86,524,607 JBrowse link
G Mmp16 matrix metallopeptidase 16 increases expression EXP Amitriptyline results in increased expression of MMP16 mRNA CTD PMID:22341215 NCBI chr 5:31,312,280...31,556,276 JBrowse link
G Mrps18b mitochondrial ribosomal protein S18B affects expression EXP Amitriptyline affects the expression of MRPS18B mRNA CTD PMID:18355885 NCBI chr20:2,842,978...2,849,065 JBrowse link
G Msmo1 methylsterol monooxygenase 1 affects expression EXP Amitriptyline affects the expression of MSMO1 mRNA CTD PMID:18355885 NCBI chr16:24,980,680...24,997,927 JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO Amitriptyline inhibits the reaction [7-ketocholesterol affects the localization of NLRP3 protein]; Amitriptyline inhibits the reaction [Cholesterol analog affects the localization of NLRP3 protein] CTD PMID:28633109 NCBI chr10:44,826,299...44,853,373 JBrowse link
G Nmb neuromedin B decreases expression EXP Amitriptyline results in decreased expression of NMB mRNA CTD PMID:22341215 NCBI chr 1:134,869,446...134,875,507 JBrowse link
G Nmur1 neuromedin U receptor 1 decreases expression EXP Amitriptyline results in decreased expression of NMUR1 mRNA CTD PMID:21820738 NCBI chr 9:94,480,002...94,486,147 JBrowse link
G Nog noggin decreases expression EXP Amitriptyline results in decreased expression of NOG mRNA CTD PMID:22341215 NCBI chr10:74,625,874...74,627,501 JBrowse link
G Nphs2 NPHS2 stomatin family member, podocin multiple interactions ISO Amitriptyline inhibits the reaction [Homocysteine results in decreased expression of NPHS2 protein] CTD PMID:23024785 NCBI chr13:68,448,720...68,461,312 JBrowse link
G Npy neuropeptide Y increases expression EXP Amitriptyline results in increased expression of NPY mRNA CTD PMID:22341215 NCBI chr 4:80,212,111...80,219,310 JBrowse link
G Npy5r neuropeptide Y receptor Y5 increases expression EXP Amitriptyline results in increased expression of NPY5R mRNA CTD PMID:21820738 NCBI chr16:23,055,427...23,063,384 JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Amitriptyline results in increased expression of NR0B2 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 5:145,779,294...145,782,609 JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 affects response to substance ISO NR3C1 protein affects the susceptibility to Amitriptyline CTD PMID:11226678 NCBI chr18:31,522,783...31,644,508 JBrowse link
G Nr3c2 nuclear receptor subfamily 3, group C, member 2 increases expression EXP Amitriptyline results in increased expression of NR3C2 mRNA CTD PMID:12393271 NCBI chr19:47,619,853...47,964,089 JBrowse link
G Nrep neuronal regeneration related protein affects expression EXP Amitriptyline affects the expression of NREP mRNA CTD PMID:18355885 NCBI chr18:25,291,219...25,320,742 JBrowse link
G Ntng1 netrin G1 decreases expression EXP Amitriptyline results in decreased expression of NTNG1 mRNA CTD PMID:22341215 NCBI chr 2:197,462,785...197,827,681 JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Amitriptyline results in increased expression of NUPR1 mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr 1:190,643,866...190,645,901 JBrowse link
G Oaf out at first homolog affects expression EXP Amitriptyline affects the expression of OAF mRNA CTD PMID:18355885 NCBI chr 8:43,594,362...43,612,334 JBrowse link
G Patj PATJ, crumbs cell polarity complex component decreases expression EXP Amitriptyline results in decreased expression of PATJ mRNA CTD PMID:22341215 NCBI chr 5:113,061,985...113,364,807 JBrowse link
G Pc pyruvate carboxylase affects expression EXP Amitriptyline affects the expression of PC mRNA CTD PMID:18355885 NCBI chr 1:211,228,708...211,327,792 JBrowse link
G Pecr peroxisomal trans-2-enoyl-CoA reductase affects expression EXP Amitriptyline affects the expression of PECR mRNA CTD PMID:18355885 NCBI chr 9:73,897,877...73,926,511 JBrowse link
G Phyh phytanoyl-CoA 2-hydroxylase increases expression ISO Amitriptyline results in increased expression of PHYH mRNA CTD PMID:15342952 NCBI chr17:73,329,461...73,346,359 JBrowse link
G Plcd4 phospholipase C, delta 4 decreases expression EXP Amitriptyline results in decreased expression of PLCD4 mRNA CTD PMID:22341215 NCBI chr 9:76,115,523...76,158,602 JBrowse link
G Plpp4 phospholipid phosphatase 4 decreases expression EXP Amitriptyline results in decreased expression of PLPP4 mRNA CTD PMID:22341215 NCBI chr 1:183,829,794...183,959,319 JBrowse link
G Por cytochrome p450 oxidoreductase affects expression EXP Amitriptyline affects the expression of POR mRNA CTD PMID:18355885 NCBI chr12:26,587,674...26,655,612 JBrowse link
G Prokr1 prokineticin receptor 1 decreases expression EXP Amitriptyline results in decreased expression of PROKR1 mRNA CTD PMID:21820738 NCBI chr 4:120,022,301...120,033,367 JBrowse link
G Pycard PYD and CARD domain containing multiple interactions ISO Amitriptyline inhibits the reaction [7-ketocholesterol affects the localization of PYCARD protein]; Amitriptyline inhibits the reaction [Cholesterol analog affects the localization of PYCARD protein] CTD PMID:28633109 NCBI chr 1:192,032,124...192,033,419 JBrowse link
G Rasd1 ras related dexamethasone induced 1 increases expression EXP Amitriptyline results in increased expression of RASD1 mRNA CTD PMID:22341215 NCBI chr10:45,265,975...45,275,279 JBrowse link
G Rbl2 RB transcriptional corepressor like 2 affects expression EXP Amitriptyline affects the expression of RBL2 mRNA CTD PMID:18355885 NCBI chr19:32,049,690...32,096,467 JBrowse link
G Reg3b regenerating family member 3 beta increases expression EXP Amitriptyline results in increased expression of REG3B mRNA CTD PMID:22341215 NCBI chr 4:110,861,775...110,865,015 JBrowse link
G Rnf112 ring finger protein 112 decreases expression EXP Amitriptyline results in decreased expression of RNF112 mRNA CTD PMID:22341215 NCBI chr10:46,620,602...46,655,745 JBrowse link
G RT1-Da RT1 class II, locus Da increases expression EXP Amitriptyline results in increased expression of RT1-DA mRNA CTD PMID:22341215 NCBI chr20:4,513,464...4,518,457 JBrowse link
G RT1-Db1 RT1 class II, locus Db1 increases expression EXP Amitriptyline results in increased expression of RT1-DB1 mRNA CTD PMID:22341215 NCBI chr20:4,548,664...4,558,237 JBrowse link
G RT1-S3 RT1 class Ib, locus S3 affects expression EXP Amitriptyline affects the expression of RT1-S3 mRNA CTD PMID:18355885 NCBI chr20:2,670,654...2,675,411 JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO Amitriptyline results in increased expression of SCD mRNA CTD PMID:16324787 NCBI chr 1:253,218,968...253,232,101 JBrowse link
G Scn11a sodium voltage-gated channel alpha subunit 11 decreases expression EXP Amitriptyline results in decreased expression of SCN11A mRNA CTD PMID:22341215 NCBI chr 8:119,495,550...119,567,044 JBrowse link
G Sema6a semaphorin 6A increases expression EXP Amitriptyline results in increased expression of SEMA6A mRNA CTD PMID:22341215 NCBI chr18:40,050,623...40,171,954 JBrowse link
G Serpina3n serpin family A member 3N increases expression ISO Amitriptyline results in increased expression of SERPINA3 mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr 6:123,323,623...123,331,181 JBrowse link
G Sh3gl3 SH3 domain containing GRB2 like 3, endophilin A3 affects expression EXP Amitriptyline affects the expression of SH3GL3 mRNA CTD PMID:18355885 NCBI chr 1:136,124,500...136,255,669 JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions
decreases activity		 ISO Amitriptyline inhibits the reaction [SLC22A1 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]
Amitriptyline results in decreased activity of SLC22A1 protein		 CTD PMID:30189235 PMID:31364238 NCBI chr 1:50,624,339...50,651,437 JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions
decreases activity		 ISO Amitriptyline inhibits the reaction [SLC22A2 protein results in increased import of 4-(4-(dimethylamino)styryl)-1-methylpyridinium iodide]; Amitriptyline inhibits the reaction [SLC22A2 protein results in increased import of Tetraethylammonium]; Amitriptyline inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Amitriptyline inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]
Amitriptyline results in decreased activity of SLC22A2 protein		 CTD PMID:21599003 PMID:23770354 PMID:28629854 PMID:30189235 PMID:31364238 NCBI chr 1:50,668,817...50,711,019 JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions ISO Amitriptyline inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid] CTD PMID:21561794 NCBI chr 1:205,522,579...205,531,179 JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression ISO Amitriptyline results in decreased expression of SLC2A3 mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr 4:157,632,887...157,698,034 JBrowse link
G Slc47a2 solute carrier family 47 member 2 multiple interactions ISO Amitriptyline inhibits the reaction [SLC47A2 protein results in increased import of Tetraethylammonium] CTD PMID:28629854 NCBI chr10:46,490,262...46,532,954 JBrowse link
G Slc6a6 solute carrier family 6 member 6 affects expression EXP Amitriptyline affects the expression of SLC6A6 mRNA CTD PMID:18355885 NCBI chr 4:124,195,186...124,268,880 JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 affects expression EXP Amitriptyline affects the expression of SLCO1A4 mRNA CTD PMID:18355885 NCBI chr 4:174,710,004...174,764,810 JBrowse link
G Smagp small cell adhesion glycoprotein increases expression EXP Amitriptyline results in increased expression of SMAGP mRNA CTD PMID:22341215 NCBI chr 7:131,720,260...131,738,711 JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 multiple interactions
increases response to substance
decreases activity		 ISO [Amitriptyline results in decreased expression of and results in decreased activity of SMPD1 protein] which results in decreased abundance of Ceramides; Amitriptyline results in decreased expression of and results in decreased activity of SMPD1 protein
SMPD1 protein results in increased susceptibility to Amitriptyline
Amitriptyline results in decreased activity of SMPD1 protein		 CTD PMID:23770692 NCBI chr 1:169,304,772...169,308,615 JBrowse link
G Sod1 superoxide dismutase 1 increases expression EXP Amitriptyline results in increased expression of SOD1 mRNA CTD PMID:10721683 NCBI chr11:42,942,742...42,948,399 JBrowse link
G Sorl1 sortilin related receptor 1 decreases expression EXP Amitriptyline results in decreased expression of SORL1 mRNA CTD PMID:22341215 NCBI chr 8:51,238,713...51,401,458 JBrowse link
G Sox11 SRY-box transcription factor 11 increases expression EXP Amitriptyline results in increased expression of SOX11 mRNA CTD PMID:22341215 NCBI chr 6:44,008,333...44,010,354 JBrowse link
G Sprr1a small proline-rich protein 1A increases expression EXP Amitriptyline results in increased expression of SPRR1A mRNA CTD PMID:22341215 NCBI chr 2:180,750,709...180,752,625 JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO Amitriptyline results in increased cleavage of and results in increased activity of SREBF1 protein CTD PMID:16324787 NCBI chr10:45,507,152...45,529,164 JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions ISO Amitriptyline results in increased cleavage of and results in increased activity of SREBF2 protein CTD PMID:16324787 NCBI chr 7:115,542,774...115,600,945 JBrowse link
G Sstr1 somatostatin receptor 1 decreases expression EXP Amitriptyline results in decreased expression of SSTR1 mRNA CTD PMID:21820738 NCBI chr 6:75,832,292...75,836,806 JBrowse link
G St13 ST13, Hsp70 interacting protein affects expression EXP Amitriptyline affects the expression of ST13 mRNA CTD PMID:18355885 NCBI chr 7:114,769,758...114,805,877 JBrowse link
G Stac2 SH3 and cysteine rich domain 2 increases expression EXP Amitriptyline results in increased expression of STAC2 mRNA CTD PMID:22341215 NCBI chr10:83,032,418...83,048,260 JBrowse link
G Stbd1 starch binding domain 1 affects expression EXP Amitriptyline affects the expression of STBD1 mRNA CTD PMID:18355885 NCBI chr14:15,470,452...15,473,857 JBrowse link
G Stmn1 stathmin 1 affects expression EXP Amitriptyline affects the expression of STMN1 mRNA CTD PMID:18355885 NCBI chr 5:151,964,308...151,970,843 JBrowse link
G Stmn4 stathmin 4 increases expression EXP Amitriptyline results in increased expression of STMN4 mRNA CTD PMID:22341215 NCBI chr15:40,541,305...40,559,253 JBrowse link
G Tagln transgelin decreases expression ISO Amitriptyline results in decreased expression of TAGLN mRNA CTD PMID:15342952 PMID:17175557 PMID:17567588 NCBI chr 8:55,121,647...55,127,121 JBrowse link
G Tex261 testis expressed 261 affects expression EXP Amitriptyline affects the expression of TEX261 mRNA CTD PMID:18355885 NCBI chr 4:116,253,547...116,260,730 JBrowse link
G Tgm1 transglutaminase 1 increases expression EXP Amitriptyline results in increased expression of TGM1 mRNA CTD PMID:22341215 NCBI chr15:29,191,039...29,206,000 JBrowse link
G Timm10b translocase of inner mitochondrial membrane 10B affects expression EXP Amitriptyline affects the expression of TIMM10B mRNA CTD PMID:18355885 NCBI chr 1:169,392,355...169,395,201 JBrowse link
G Trh thyrotropin releasing hormone multiple interactions ISO Amitriptyline inhibits the reaction [TRH protein results in decreased expression of TSHB protein] CTD PMID:6455462 NCBI chr 4:124,742,111...124,777,094 JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions EXP Amitriptyline inhibits the reaction [[Capsaicin results in increased activity of TRPV1 protein] which results in increased uptake of Calcium] CTD PMID:23264033 NCBI chr10:58,349,936...58,375,021 JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions ISO Amitriptyline inhibits the reaction [TRH protein results in decreased expression of TSHB protein] CTD PMID:6455462 NCBI chr 2:190,224,676...190,229,559 JBrowse link
G Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1 affects expression EXP Amitriptyline affects the expression of UBA52 mRNA CTD PMID:18355885 NCBI chr16:18,952,583...18,954,780 JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 affects expression EXP Amitriptyline affects the expression of UGT1A1 mRNA CTD PMID:18355885 NCBI chr 9:96,249,143...96,256,264 JBrowse link
G Ugt2a1 UDP glucuronosyltransferase family 2 member A1 affects expression EXP Amitriptyline affects the expression of UGT2A1 mRNA CTD PMID:18355885 NCBI chr14:20,521,018...20,545,934 JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 affects expression EXP Amitriptyline affects the expression of UGT2B1 mRNA CTD PMID:18355885 NCBI chr14:21,378,882...21,390,631 JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Amitriptyline inhibits the reaction [Homocysteine results in decreased secretion of VEGFA protein] CTD PMID:23024785 NCBI chr 9:22,452,854...22,468,194 JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Amitriptyline results in increased expression of WIPI1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr10:95,042,451...95,079,679 JBrowse link
azatadine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hrh1 histamine receptor H 1 multiple interactions ISO azatadine binds to and results in decreased activity of HRH1 protein CTD PMID:2864258 NCBI chr 4:149,120,511...149,204,267 JBrowse link
benzphetamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases metabolic processing ISO CYP2B6 protein results in increased metabolism of Benzphetamine CTD PMID:12464242 PMID:15769884 NCBI chr 1:90,780,468...90,859,852 JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO Benzphetamine inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin] CTD PMID:19299527 NCBI chr12:14,321,771...14,343,886 JBrowse link
bepridil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO Bepridil inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] CTD PMID:11895100 NCBI chr 4:26,312,403...26,488,456 JBrowse link
G Atf4 activating transcription factor 4 increases expression ISO Bepridil results in increased expression of ATF4 protein CTD PMID:21292685 NCBI chr 7:113,684,681...113,686,739 JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects metabolic processing ISO CYP3A4 protein affects the metabolism of Bepridil CTD PMID:15286053 NCBI chr12:14,321,771...14,343,886 JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Bepridil results in increased expression of DDIT3 protein CTD PMID:21292685 NCBI chr 7:65,001,695...65,006,517 JBrowse link
G Eif2a eukaryotic translation initiation factor 2A increases phosphorylation ISO Bepridil results in increased phosphorylation of EIF2A protein CTD PMID:21292685 NCBI chr 2:142,761,303...142,794,767 JBrowse link
G Kcna5 potassium voltage-gated channel subfamily A member 5 decreases activity ISO Bepridil results in decreased activity of KCNA5 protein CTD PMID:11711026 NCBI chr 4:161,040,853...161,044,311 JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity		 ISO Bepridil binds to and results in decreased activity of KCNH2 protein; Bepridil inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Bepridil results in decreased activity of KCNH2 protein		 CTD PMID:15272206 PMID:15671647 PMID:21158687 PMID:24052561 NCBI chr 4:11,719,357...11,751,424 JBrowse link
G Slc8a1 solute carrier family 8 member A1 multiple interactions ISO Bepridil inhibits the reaction [SLC8A1 protein results in increased susceptibility to Chlorodiphenyl (54% Chlorine)] CTD PMID:16009740 NCBI chr 6:13,194,609...13,547,369 JBrowse link
G Tnfsf10 TNF superfamily member 10 increases response to substance ISO Bepridil results in increased susceptibility to TNFSF10 protein CTD PMID:21292685 NCBI chr 2:112,136,550...112,155,903 JBrowse link
butenafine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA] CTD PMID:23688403 NCBI chr10:68,820,330...68,824,906 JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [Biological Products results in increased expression of CXCL10 protein]]; butenafine inhibits the reaction [Biological Products results in increased expression of CXCL10 mRNA]; butenafine inhibits the reaction [Biological Products results in increased expression of CXCL10 protein] CTD PMID:24471457 NCBI chr14:15,989,066...15,991,263 JBrowse link
G Il4 interleukin 4 multiple interactions ISO 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Thromboxane B2]; butenafine promotes the reaction [[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprostone] CTD PMID:23688403 NCBI chr10:38,272,003...38,277,549 JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein] CTD PMID:23688403 NCBI chr 6:78,593,844...78,597,307 JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO butenafine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019 JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [Biological Products results in increased activity of STAT1 protein]]; butenafine inhibits the reaction [Biological Products results in increased phosphorylation of and results in increased activity of STAT1 protein] CTD PMID:24471457 NCBI chr 9:56,911,522...56,951,926 JBrowse link
G Tslp thymic stromal lymphopoietin multiple interactions ISO 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein] CTD PMID:23688403 NCBI chr18:24,723,990...24,728,419 JBrowse link
chloroprocaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 ISO chloroprocaine results in increased expression of BAX protein
LINC00494 inhibits the reaction [chloroprocaine results in increased expression of BAX protein]		 CTD PMID:37650745 NCBI chr 1:105,076,472...105,081,906 JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions		 ISO chloroprocaine results in decreased expression of CCND1 protein
LINC00494 inhibits the reaction [chloroprocaine results in decreased expression of CCND1 protein]		 CTD PMID:37650745 NCBI chr 1:209,518,288...209,527,986 JBrowse link
G Med19 mediator complex subunit 19 decreases expression
multiple interactions		 ISO chloroprocaine results in decreased expression of MED19 mRNA; chloroprocaine results in decreased expression of MED19 protein
LINC00494 inhibits the reaction [chloroprocaine results in decreased expression of MED19 mRNA]; LINC00494 inhibits the reaction [chloroprocaine results in decreased expression of MED19 protein]		 CTD PMID:37650745 NCBI chr 3:69,762,138...69,772,661 JBrowse link
G Pcna proliferating cell nuclear antigen decreases expression
multiple interactions		 ISO chloroprocaine results in decreased expression of PCNA protein
LINC00494 inhibits the reaction [chloroprocaine results in decreased expression of PCNA protein]		 CTD PMID:37650745 NCBI chr 3:139,951,948...139,955,820 JBrowse link
chlorpromazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases expression		 ISO
EXP		 [Chlorpromazine co-treated with Cholic Acids] affects the expression of ABCB11 mRNA
Chlorpromazine results in decreased expression of ABCB11 mRNA; Chlorpromazine results in decreased expression of ABCB11 protein		 CTD PMID:27344345 PMID:27765674 PMID:28391356 PMID:35708773 NCBI chr 3:74,424,620...74,520,646 JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A increases expression
decreases activity		 ISO Chlorpromazine analog results in increased expression of ABCB1 mRNA
Chlorpromazine results in decreased activity of ABCB1 protein		 CTD PMID:15924885 PMID:16810505 NCBI chr 4:26,312,403...26,488,456 JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B affects activity EXP Chlorpromazine affects the activity of ABCB1B protein CTD PMID:12626638 NCBI chr 4:26,197,706...26,280,156 JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 multiple interactions ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of ABCB4 mRNA CTD PMID:27344345 NCBI chr 4:26,106,895...26,164,440 JBrowse link
G Abcb6 ATP binding cassette subfamily B member 6 decreases expression EXP Chlorpromazine results in decreased expression of ABCB6 mRNA CTD PMID:25596134 NCBI chr 9:84,117,222...84,125,939 JBrowse link
G Abcb9 ATP binding cassette subfamily B member 9 increases expression EXP Chlorpromazine results in increased expression of ABCB9 mRNA CTD PMID:25596134 NCBI chr12:32,499,213...32,531,932 JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression
multiple interactions		 EXP
ISO		 Chlorpromazine results in increased expression of ABCC2 mRNA
[Bile Acids and Salts co-treated with Chlorpromazine] results in decreased expression of ABCC2 mRNA		 CTD PMID:27765674 PMID:35708773 NCBI chr 1:252,613,875...252,672,459 JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression
multiple interactions
decreases expression		 ISO
EXP		 Chlorpromazine analog results in increased expression of ABCC3 mRNA
[Bile Acids and Salts co-treated with Chlorpromazine] results in decreased expression of ABCC3 mRNA
Chlorpromazine results in decreased expression of ABCC3 mRNA		 CTD PMID:15924885 PMID:25596134 PMID:35708773 NCBI chr10:79,793,571...79,839,528 JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 increases expression ISO Chlorpromazine results in increased expression of ABCC4 mRNA CTD PMID:35708773 NCBI chr15:101,948,387...102,182,912 JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions ISO Chlorpromazine inhibits the reaction [ABCG2 protein results in increased transport of Mitoxantrone] CTD PMID:18834354 NCBI chr 4:89,006,056...89,132,915 JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 multiple interactions ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of ABCG8 mRNA CTD PMID:27344345 NCBI chr 6:9,945,629...9,964,912 JBrowse link
G Acaca acetyl-CoA carboxylase alpha decreases phosphorylation EXP Chlorpromazine results in decreased phosphorylation of ACACA protein CTD PMID:17512020 NCBI chr10:69,511,627...69,773,888 JBrowse link
G Ace2 angiotensin converting enzyme 2 decreases expression ISO Chlorpromazine results in decreased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:30,293,597...30,340,961 JBrowse link
G Ache acetylcholinesterase decreases activity
increases activity
multiple interactions		 ISO Chlorpromazine results in decreased activity of ACHE protein
Chlorpromazine results in increased activity of ACHE protein
Dichlorvos promotes the reaction [Chlorpromazine results in decreased activity of ACHE protein]		 CTD PMID:4859365 PMID:29614332 NCBI chr12:25,042,882...25,050,608 JBrowse link
G Acp5 acid phosphatase 5, tartrate resistant multiple interactions ISO Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA] CTD PMID:21869564 NCBI chr 8:28,939,984...28,946,639 JBrowse link
G Adra1a adrenoceptor alpha 1A decreases activity EXP Chlorpromazine results in decreased activity of ADRA1A protein CTD PMID:23611293 NCBI chr15:45,005,648...45,111,416 JBrowse link
G Adra1b adrenoceptor alpha 1B decreases activity EXP Chlorpromazine results in decreased activity of ADRA1B protein CTD PMID:23611293 NCBI chr10:28,255,025...28,373,418 JBrowse link
G Afp alpha-fetoprotein decreases expression ISO Chlorpromazine analog results in decreased expression of AFP mRNA CTD PMID:15924885 NCBI chr14:17,573,412...17,591,476 JBrowse link
G Agrn agrin decreases expression EXP Chlorpromazine results in decreased expression of AGRN mRNA CTD PMID:25596134 NCBI chr 5:172,031,528...172,064,429 JBrowse link
G Ahr aryl hydrocarbon receptor affects activity EXP Chlorpromazine affects the activity of AHR protein CTD PMID:25596134 NCBI chr 6:57,961,423...57,998,901 JBrowse link
G Ak3 adenylate kinase 3 decreases expression EXP Chlorpromazine results in decreased expression of AK3 mRNA CTD PMID:25596134 NCBI chr 1:236,151,012...236,178,689 JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation EXP Chlorpromazine results in decreased phosphorylation of AKT1 protein CTD PMID:17512020 NCBI chr 6:137,534,810...137,555,131 JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 multiple interactions ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of ALDH1A1 mRNA CTD PMID:27344345 NCBI chr 1:218,000,470...218,152,962 JBrowse link
G Aldoa aldolase, fructose-bisphosphate A increases expression EXP Chlorpromazine results in increased expression of ALDOA mRNA CTD PMID:25596134 NCBI chr 1:181,402,275...181,407,476 JBrowse link
G Alpp alkaline phosphatase, placental multiple interactions ISO Chlorpromazine inhibits the reaction [Colforsin results in increased expression of ALPP mRNA]; Chlorpromazine inhibits the reaction [Isoproterenol results in increased expression of ALPP mRNA] CTD PMID:16036225 NCBI chr 9:95,213,763...95,216,509 JBrowse link
G Ap1s1 adaptor related protein complex 1 subunit sigma 1 decreases expression ISO Chlorpromazine results in decreased expression of AP1S1 mRNA CTD PMID:17175557 NCBI chr12:19,625,267...19,635,792 JBrowse link
G Apoc4 apolipoprotein C4 multiple interactions ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of APOC4 mRNA CTD PMID:27344345 NCBI chr 1:79,335,745...79,339,942 JBrowse link
G Apof apolipoprotein F multiple interactions ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of APOF mRNA CTD PMID:27344345 NCBI chr 7:700,688...702,130 JBrowse link
G Areg amphiregulin decreases expression ISO Chlorpromazine results in decreased expression of AREG mRNA CTD PMID:15924885 PMID:30703373 NCBI chr14:17,256,384...17,265,641 JBrowse link
G Arfgef2 ARF guanine nucleotide exchange factor 2 increases expression EXP Chlorpromazine results in increased expression of ARFGEF2 mRNA CTD PMID:25596134 NCBI chr 3:155,547,504...155,633,652 JBrowse link
G Arhgef10 Rho guanine nucleotide exchange factor 10 decreases expression EXP Chlorpromazine results in decreased expression of ARHGEF10 mRNA CTD PMID:25596134 NCBI chr16:74,647,147...74,738,784 JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 increases expression ISO Chlorpromazine results in increased expression of ASAH1 mRNA CTD PMID:17175557 NCBI chr16:57,669,927...57,701,349 JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Chlorpromazine results in increased expression of ASNS mRNA CTD PMID:17175557 NCBI chr 4:36,752,061...36,769,970 JBrowse link
G Atf4 activating transcription factor 4 affects activity
multiple interactions		 EXP
ISO		 Chlorpromazine affects the activity of ATF4 protein
[Chlorpromazine co-treated with Cholic Acids] affects the expression of ATF4 mRNA		 CTD PMID:25596134 PMID:27344345 NCBI chr 7:113,684,681...113,686,739 JBrowse link
G Atp6v1b2 ATPase H+ transporting V1 subunit B2 decreases expression EXP Chlorpromazine results in decreased expression of ATP6V1B2 protein CTD PMID:19441803 NCBI chr16:20,617,515...20,641,651 JBrowse link
G Avp arginine vasopressin increases expression
multiple interactions		 ISO
EXP		 Chlorpromazine results in increased expression of AVP protein
Chlorpromazine inhibits the reaction [Lithium results in increased expression of AVP protein]		 CTD PMID:3567260 PMID:3976404 NCBI chr 3:138,246,544...138,248,522 JBrowse link
G Bag4 BAG cochaperone 4 decreases expression ISO Chlorpromazine analog results in decreased expression of BAG4 mRNA CTD PMID:15924885 NCBI chr16:66,288,678...66,305,893 JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression ISO Chlorpromazine results in increased expression of BCL2L1 mRNA CTD PMID:21683644 NCBI chr 3:161,713,777...161,764,844 JBrowse link
G Bdnf brain-derived neurotrophic factor affects response to substance
affects expression		 ISO
EXP		 BDNF affects the susceptibility to Chlorpromazine
Chlorpromazine affects the expression of BDNF mRNA		 CTD PMID:18408624 PMID:31324950 NCBI chr 3:116,619,633...116,670,212 JBrowse link
G Bhlhe40 basic helix-loop-helix family, member e40 increases expression ISO Chlorpromazine analog results in increased expression of BHLHE40 mRNA CTD PMID:15924885 NCBI chr 4:141,618,453...141,624,154 JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 decreases expression ISO Chlorpromazine results in decreased expression of BIRC2 mRNA CTD PMID:30703373 NCBI chr 8:13,253,697...13,273,672 JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO Chlorpromazine analog results in decreased expression of BIRC5 mRNA; Chlorpromazine results in decreased expression of BIRC5 mRNA CTD PMID:15924885 PMID:30703373 NCBI chr10:103,567,369...103,580,069 JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression EXP Chlorpromazine results in increased expression of BNIP3 mRNA CTD PMID:25596134 NCBI chr 1:203,137,778...203,154,962 JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression ISO Chlorpromazine analog results in increased expression of BTG2 mRNA CTD PMID:15924885 NCBI chr13:48,083,931...48,087,690 JBrowse link
G Btg3 BTG anti-proliferation factor 3 increases expression ISO Chlorpromazine analog results in increased expression of BTG3 mRNA CTD PMID:15924885 NCBI chr11:17,030,156...17,046,069 JBrowse link
G C3 complement C3 multiple interactions ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of C3 mRNA CTD PMID:27344345 NCBI chr 9:2,174,412...2,201,339 JBrowse link
G C6 complement C6 multiple interactions ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of C6 mRNA CTD PMID:27344345 NCBI chr 2:53,846,028...53,921,279 JBrowse link
G Calcr calcitonin receptor multiple interactions ISO Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA] CTD PMID:21869564 NCBI chr 4:31,661,270...31,736,392 JBrowse link
G Calr calreticulin decreases expression EXP Chlorpromazine results in decreased expression of CALR mRNA CTD PMID:18246545 NCBI chr19:40,213,367...40,218,262 JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions ISO Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of CAR2 mRNA] CTD PMID:21869564 NCBI chr 2:88,462,883...88,478,012 JBrowse link
G Cat catalase multiple interactions
decreases expression
decreases activity		 EXP
ISO		 carvedilol inhibits the reaction [Chlorpromazine results in decreased expression of CAT protein]; zolpidem inhibits the reaction [Chlorpromazine results in decreased activity of CAT] CTD PMID:12010767 PMID:17513028 PMID:25449126 NCBI chr 3:110,297,340...110,329,526 JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression ISO Chlorpromazine results in decreased expression of CCN2 mRNA; Chlorpromazine results in decreased expression of CCN2 protein CTD PMID:30703373 NCBI chr 1:22,621,498...22,624,614 JBrowse link
G Ccn3 cellular communication network factor 3 affects expression EXP Chlorpromazine affects the expression of CCN3 mRNA CTD PMID:31324950 NCBI chr 7:87,983,788...87,990,810 JBrowse link
G Ccnb2 cyclin B2 decreases expression ISO Chlorpromazine analog results in decreased expression of CCNB2 mRNA; Chlorpromazine results in decreased expression of CCNB2 mRNA CTD PMID:15924885 NCBI chr 8:79,968,459...79,981,717 JBrowse link
G Ccnd1 cyclin D1 decreases expression EXP Chlorpromazine results in decreased expression of CCND1 mRNA CTD PMID:17202759 NCBI chr 1:209,518,288...209,527,986 JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO Chlorpromazine analog results in decreased expression of CCND3 mRNA CTD PMID:15924885 NCBI chr 9:20,891,696...20,987,199 JBrowse link
G Ccnf cyclin F decreases expression ISO Chlorpromazine analog results in decreased expression of CCNF mRNA CTD PMID:15924885 NCBI chr10:13,757,884...13,783,669 JBrowse link
G Cd274 CD274 molecule multiple interactions ISO Chlorpromazine inhibits the reaction [platycodin D results in decreased expression of and results in increased secretion of CD274 protein] CTD PMID:31150782 NCBI chr 1:236,526,215...236,549,956 JBrowse link
G Cd44 CD44 molecule multiple interactions
decreases expression		 ISO Chlorpromazine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CD44 protein]
Chlorpromazine results in decreased expression of CD44 protein		 CTD PMID:9929743 PMID:30703373 NCBI chr 3:109,610,824...109,699,776 JBrowse link
G Cd86 CD86 molecule increases expression ISO Chlorpromazine results in increased expression of CD86 protein CTD PMID:19665512 NCBI chr11:77,647,565...77,706,178 JBrowse link
G Cdk5 cyclin-dependent kinase 5 decreases expression ISO Chlorpromazine analog results in decreased expression of CDK5 mRNA CTD PMID:15924885 NCBI chr 4:11,647,098...11,651,606 JBrowse link
G Cdk7 cyclin-dependent kinase 7 increases expression ISO Chlorpromazine analog results in increased expression of CDK7 mRNA CTD PMID:15924885 NCBI chr 2:33,574,623...33,599,485 JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression		 EXP [EGR1 binds to CDKN1A promoter] promotes the reaction [Chlorpromazine results in increased expression of CDKN1A mRNA]; EGR1 promotes the reaction [Chlorpromazine results in increased expression of CDKN1A mRNA] CTD PMID:20368687 NCBI chr20:7,150,820...7,161,373 JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C decreases expression ISO Chlorpromazine analog results in decreased expression of CDKN2C mRNA CTD PMID:15924885 NCBI chr 5:129,639,736...129,645,564 JBrowse link
G Ces2h carboxylesterase 2H multiple interactions ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of CES2 mRNA CTD PMID:27344345 NCBI chr19:32,974,242...32,988,842 JBrowse link
G Cfh complement factor H multiple interactions ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of CFH mRNA CTD PMID:27344345 NCBI chr13:51,512,376...51,613,829 JBrowse link
G Cgref1 cell growth regulator with EF hand domain 1 decreases expression EXP Chlorpromazine results in decreased expression of CGREF1 mRNA CTD PMID:17202759 NCBI chr 6:25,431,846...25,443,853 JBrowse link
G Chtf18 chromosome transmission fidelity factor 18 decreases expression ISO Chlorpromazine analog results in decreased expression of CHTF18 mRNA CTD PMID:15924885 NCBI chr10:15,247,525...15,255,573 JBrowse link
G Cited2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 decreases expression EXP Chlorpromazine results in decreased expression of CITED2 mRNA CTD PMID:18246545 NCBI chr 1:12,312,426...12,314,869 JBrowse link
G Cks2 CDC28 protein kinase regulatory subunit 2 decreases expression ISO Chlorpromazine analog results in decreased expression of CKS2 mRNA CTD PMID:15924885 NCBI chr17:13,570,611...13,575,770 JBrowse link
G Clcf1 cardiotrophin-like cytokine factor 1 increases expression ISO Chlorpromazine results in increased expression of CLCF1 mRNA CTD PMID:21683644 NCBI chr 1:201,507,763...201,517,607 JBrowse link
G Col18a1 collagen type XVIII alpha 1 chain multiple interactions ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of COL18A1 mRNA CTD PMID:27344345 NCBI chr20:11,474,104...11,582,593 JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO Chlorpromazine results in increased expression of COL1A1 mRNA CTD PMID:35708773 NCBI chr10:80,380,458...80,397,461 JBrowse link
G Col4a1 collagen type IV alpha 1 chain decreases expression EXP Chlorpromazine results in decreased expression of COL4A1 mRNA CTD PMID:25596134 NCBI chr16:84,885,597...84,996,482 JBrowse link
G Cort cortistatin affects expression EXP Chlorpromazine affects the expression of CORT mRNA CTD PMID:31324950 NCBI chr 5:159,560,591...159,562,032 JBrowse link
G Cox8a cytochrome c oxidase subunit 8A affects expression
increases expression		 EXP Chlorpromazine affects the expression of COX8A mRNA
Chlorpromazine results in increased expression of COX8A mRNA		 CTD PMID:18246545 NCBI chr 1:213,831,302...213,833,623 JBrowse link
G Crh corticotropin releasing hormone decreases expression ISO Chlorpromazine results in decreased expression of CRH mRNA CTD PMID:16205782 NCBI chr 2:104,059,184...104,061,048 JBrowse link
G Cth cystathionine gamma-lyase decreases expression EXP Chlorpromazine results in decreased expression of CTH mRNA CTD PMID:25596134 NCBI chr 2:249,634,731...249,661,066 JBrowse link
G Ctsk cathepsin K multiple interactions ISO Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA] CTD PMID:21869564 NCBI chr 2:185,747,548...185,758,512 JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
decreases response to substance
increases expression		 ISO
EXP		 [Filipin co-treated with Chlorpromazine co-treated with Wortmannin] inhibits the reaction [Particulate Matter results in increased expression of CYP1A1 mRNA]; Chlorpromazine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]
Chlorpromazine results in decreased activity of CYP1A1 protein
CYP1A1 protein results in decreased susceptibility to Chlorpromazine
Chlorpromazine results in increased expression of CYP1A1 mRNA		 CTD PMID:17202759 PMID:18246545 PMID:18493746 PMID:25596134 PMID:26477383 More... NCBI chr 8:66,991,940...66,998,014 JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases response to substance
increases expression
increases oxidation
affects expression
decreases methylation		 ISO
EXP		 [Chlorpromazine co-treated with Cholic Acids] affects the expression of CYP1A2 mRNA; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Chlorpromazine; Chlorpromazine inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]; CYP1A2 protein results in increased metabolism of and results in increased activity of Chlorpromazine
CYP1A2 protein results in decreased susceptibility to Chlorpromazine
Chlorpromazine results in increased expression of CYP1A2 mRNA
CYP1A2 protein results in increased oxidation of Chlorpromazine
Chlorpromazine affects the expression of CYP1A2 mRNA
CYP1A2 protein results in decreased methylation of Chlorpromazine		 CTD PMID:18246545 PMID:18493746 PMID:19482014 PMID:20615392 PMID:23397584 More... NCBI chr 8:66,971,261...66,978,149 JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases response to substance
decreases activity
multiple interactions		 ISO CYP1B1 protein results in decreased susceptibility to Chlorpromazine
Chlorpromazine results in decreased activity of CYP1B1 protein
[Filipin co-treated with Chlorpromazine co-treated with Wortmannin] inhibits the reaction [Particulate Matter results in increased expression of CYP1B1 mRNA]		 CTD PMID:26477383 PMID:29724254 PMID:33814510 NCBI chr 6:21,093,927...21,103,091 JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
decreases response to substance		 ISO [Chlorpromazine results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; Chlorpromazine inhibits the reaction [Androstenols inhibits the reaction [NR1I3 protein results in increased expression of CYP2B6 mRNA]]
NR1I3 protein affects the reaction [Chlorpromazine results in increased expression of CYP2B10 mRNA]
CYP2B6 protein results in decreased susceptibility to Chlorpromazine		 CTD PMID:10037683 PMID:12049174 PMID:17041008 PMID:26477383 NCBI chr 1:90,780,468...90,859,852 JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases expression
decreases response to substance		 EXP
ISO		 Chlorpromazine results in decreased expression of CYP2C mRNA; Chlorpromazine results in decreased expression of CYP2C11 mRNA
CYP2C18 protein results in decreased susceptibility to Chlorpromazine		 CTD PMID:18246545 PMID:26477383 NCBI chr 1:246,175,216...246,211,445 JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 multiple interactions
decreases response to substance
decreases activity
affects methylation		 ISO [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Chlorpromazine
CYP2C19 protein results in decreased susceptibility to Chlorpromazine
Chlorpromazine results in decreased activity of CYP2C19 protein
CYP2C19 protein affects the methylation of Chlorpromazine		 CTD PMID:15135088 PMID:20615392 PMID:23397584 PMID:26477383 NCBI chr 1:247,879,058...247,916,804 JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases response to substance ISO CYP2C8 protein results in decreased susceptibility to Chlorpromazine CTD PMID:26477383
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions
decreases response to substance		 ISO [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Chlorpromazine; CYP2D6 protein results in increased metabolism of and results in increased activity of Chlorpromazine
CYP2D6 protein results in decreased susceptibility to Chlorpromazine		 CTD PMID:19482014 PMID:23397584 PMID:26477383 NCBI chr 7:115,762,662...115,771,832 JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity
decreases response to substance		 ISO Chlorpromazine results in decreased activity of CYP2E1 protein
CYP2E1 protein results in decreased susceptibility to Chlorpromazine		 CTD PMID:15135088 PMID:26477383 NCBI chr 1:205,269,967...205,280,365 JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 affects methylation
affects oxidation
multiple interactions
decreases response to substance
decreases activity		 ISO CYP3A4 protein affects the methylation of Chlorpromazine
CYP3A4 protein affects the oxidation of Chlorpromazine
[Chlorpromazine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Chlorpromazine
CYP3A4 protein results in decreased susceptibility to Chlorpromazine
Chlorpromazine results in decreased activity of CYP3A4 protein		 CTD PMID:15135088 PMID:17041008 PMID:20615392 PMID:23397584 PMID:26477383 NCBI chr12:14,321,771...14,343,886 JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 decreases response to substance ISO CYP3A5 protein results in decreased susceptibility to Chlorpromazine CTD PMID:26477383 NCBI chr12:21,919,955...21,960,160 JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 multiple interactions ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of CYP8B1 mRNA CTD PMID:27344345 NCBI chr 8:130,455,622...130,457,592 JBrowse link
G Dao D-amino-acid oxidase decreases activity ISO Chlorpromazine results in decreased activity of DAO protein CTD PMID:18615285 NCBI chr12:42,592,342...42,613,046 JBrowse link
G Dcstamp dendrocyte expressed seven transmembrane protein multiple interactions ISO Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA] CTD PMID:21869564 NCBI chr 7:70,807,455...70,822,067 JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression EXP Chlorpromazine results in increased expression of DDIT3 mRNA CTD PMID:25596134 NCBI chr 7:65,001,695...65,006,517 JBrowse link
G Depp1 DEPP autophagy regulator 1 increases expression ISO Chlorpromazine results in increased expression of DEPP1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 4:149,910,794...149,913,013 JBrowse link
G Drd1 dopamine receptor D1 decreases activity ISO Chlorpromazine results in decreased activity of DRD1 protein CTD PMID:23611293 NCBI chr17:10,545,488...10,550,029 JBrowse link
G Drd2 dopamine receptor D2 decreases response to substance
decreases activity		 ISO DRD2 polymorphism results in decreased susceptibility to Chlorpromazine
Chlorpromazine results in decreased activity of DRD2 protein		 CTD PMID:15694263 PMID:23611293 NCBI chr 8:58,605,403...58,669,339 JBrowse link
G Dusp1 dual specificity phosphatase 1 increases expression
affects expression		 ISO Chlorpromazine analog results in increased expression of DUSP1 mRNA
Chlorpromazine affects the expression of DUSP1 mRNA		 CTD PMID:15924885 PMID:20843724 NCBI chr10:17,184,853...17,187,646 JBrowse link
G Dusp9 dual specificity phosphatase 9 decreases expression ISO Chlorpromazine analog results in decreased expression of DUSP9 mRNA CTD PMID:15924885 NCBI chr  X:151,351,897...151,355,822 JBrowse link
G E2f1 E2F transcription factor 1 decreases expression ISO Chlorpromazine analog results in decreased expression of E2F1 mRNA CTD PMID:15924885 NCBI chr 3:163,524,739...163,535,563 JBrowse link
G Egr1 early growth response 1 increases expression
multiple interactions		 EXP Chlorpromazine results in increased expression of EGR1
[EGR1 binds to CDKN1A promoter] promotes the reaction [Chlorpromazine results in increased expression of CDKN1A mRNA]; EGR1 promotes the reaction [Chlorpromazine results in increased expression of CDKN1A mRNA]; MAPK1 affects the reaction [Chlorpromazine results in increased expression of EGR1]; MAPK3 affects the reaction [Chlorpromazine results in increased expression of EGR1]		 CTD PMID:20368687 NCBI chr18:26,737,078...26,740,877 JBrowse link
G Eif1 eukaryotic translation initiation factor 1 increases expression EXP Chlorpromazine results in increased expression of EIF1 mRNA CTD PMID:25596134 NCBI chr10:85,747,064...85,749,447 JBrowse link
G Eno2 enolase 2 increases expression EXP Chlorpromazine results in increased expression of ENO2 mRNA CTD PMID:25596134 NCBI chr 4:159,258,371...159,267,220 JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha increases expression EXP Chlorpromazine results in increased expression of ERO1A mRNA CTD PMID:25596134 NCBI chr15:18,495,037...18,530,440 JBrowse link
G F2 coagulation factor II, thrombin decreases expression ISO Chlorpromazine analog results in decreased expression of F2 mRNA CTD PMID:15924885 NCBI chr 3:98,051,958...98,065,246 JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO Chlorpromazine results in increased expression of FABP1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 4:104,744,302...104,753,119 JBrowse link
G Fas Fas cell surface death receptor increases expression ISO Chlorpromazine analog results in increased expression of FAS mRNA CTD PMID:15924885 NCBI chr 1:241,212,155...241,245,774 JBrowse link
G Fbp1 fructose-bisphosphatase 1 multiple interactions ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of FBP1 mRNA CTD PMID:27344345 NCBI chr17:2,207,271...2,230,076 JBrowse link
G Fbxo22 F-box protein 22 decreases expression EXP Chlorpromazine results in decreased expression of FBXO22 mRNA CTD PMID:25596134 NCBI chr 8:64,476,034...64,492,063 JBrowse link
G Fech ferrochelatase decreases expression EXP Chlorpromazine results in decreased expression of FECH mRNA CTD PMID:25596134 NCBI chr18:57,945,123...57,978,327 JBrowse link
G Fetub fetuin B multiple interactions ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of FETUB mRNA CTD PMID:27344345 NCBI chr11:78,082,158...78,093,022 JBrowse link
G Fga fibrinogen alpha chain multiple interactions ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of FGA mRNA CTD PMID:27344345 NCBI chr 2:170,672,169...170,679,572 JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of FGF2 mRNA CTD PMID:27344345 NCBI chr 2:122,164,454...122,218,796 JBrowse link
G Fgfr1 Fibroblast growth factor receptor 1 decreases expression ISO Chlorpromazine analog results in decreased expression of FGFR1 mRNA CTD PMID:15924885 NCBI chr16:73,194,631...73,249,855 JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase decreases expression EXP Chlorpromazine results in decreased expression of FGR mRNA CTD PMID:25596134 NCBI chr 5:150,473,767...150,503,524 JBrowse link
G Fkbp5 FKBP prolyl isomerase 5 multiple interactions ISO Chlorpromazine inhibits the reaction [Lipopolysaccharides results in decreased expression of FKBP5 protein] CTD PMID:21034739 NCBI chr20:6,458,931...6,577,227 JBrowse link
G Fndc4 fibronectin type III domain containing 4 increases expression ISO Chlorpromazine results in increased expression of FNDC4 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 6:25,077,155...25,080,812 JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit affects expression ISO Chlorpromazine affects the expression of FOS mRNA CTD PMID:20843724 NCBI chr 6:110,852,188...110,855,054 JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit affects expression ISO Chlorpromazine affects the expression of FOSB mRNA CTD PMID:20843724 NCBI chr 1:88,082,324...88,089,506 JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression
affects expression		 ISO Chlorpromazine analog results in increased expression of FOSL1 mRNA
Chlorpromazine affects the expression of FOSL1 mRNA		 CTD PMID:15924885 PMID:20843724 NCBI chr 1:212,183,885...212,192,391 JBrowse link
G Fosl2 FOS like 2, AP-1 transcription factor subunit affects expression ISO Chlorpromazine affects the expression of FOSL2 mRNA CTD PMID:20843724 NCBI chr 6:30,017,952...30,039,269 JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of FTH1 mRNA CTD PMID:27344345 NCBI chr 1:216,052,037...216,054,325 JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases expression
decreases activity
multiple interactions		 ISO
EXP		 Chlorpromazine analog results in decreased expression of G6PD mRNA
Chlorpromazine results in decreased activity of G6PD protein
[Taurine co-treated with coenzyme Q10] inhibits the reaction [Chlorpromazine results in decreased activity of G6PD protein]; coenzyme Q10 inhibits the reaction [Chlorpromazine results in decreased activity of G6PD protein]; Taurine inhibits the reaction [Chlorpromazine results in decreased activity of G6PD protein]		 CTD PMID:15924885 PMID:33548410 NCBI chr  X:157,352,364...157,372,144 JBrowse link
G Gad1 glutamate decarboxylase 1 decreases methylation
multiple interactions		 ISO Chlorpromazine results in decreased methylation of GAD1 promoter
Valproic Acid promotes the reaction [Chlorpromazine results in decreased methylation of GAD1 promoter]		 CTD PMID:19110320 NCBI chr 3:75,777,260...75,818,099 JBrowse link
G Gcgr glucagon receptor multiple interactions ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of GCGR mRNA CTD PMID:27344345 NCBI chr10:106,306,803...106,314,970 JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit decreases expression EXP Chlorpromazine results in decreased expression of GCLC mRNA CTD PMID:25596134 NCBI chr 8:87,510,251...87,548,896 JBrowse link
G Gdf15 growth differentiation factor 15 increases expression EXP Chlorpromazine results in increased expression of GDF15 mRNA CTD PMID:25596134 NCBI chr16:18,838,436...18,842,022 JBrowse link
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 increases expression ISO Chlorpromazine results in increased expression of GDPD3 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 1:181,373,505...181,383,063 JBrowse link
G Gfap glial fibrillary acidic protein affects expression EXP Chlorpromazine affects the expression of GFAP mRNA CTD PMID:31324950 NCBI chr10:88,352,987...88,361,661 JBrowse link
G Gpnmb glycoprotein nmb increases expression EXP Chlorpromazine results in increased expression of GPNMB mRNA CTD PMID:25596134 NCBI chr 4:79,341,128...79,362,366 JBrowse link
G Gpt glutamic--pyruvic transaminase increases expression EXP Chlorpromazine results in increased expression of GPT protein CTD PMID:35722787 NCBI chr 7:110,295,599...110,300,134 JBrowse link
G Gsr glutathione-disulfide reductase decreases activity EXP Chlorpromazine results in decreased activity of GSR protein CTD PMID:6693892 NCBI chr16:65,185,574...65,228,742 JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of GSTA1 mRNA CTD PMID:27344345 NCBI chr 9:23,703,476...23,720,121 JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha affects activity EXP Chlorpromazine affects the activity of HIF1A protein CTD PMID:25596134 NCBI chr 6:98,357,788...98,405,068 JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases expression ISO Chlorpromazine results in increased expression of HMGCR mRNA CTD PMID:17052361 NCBI chr 2:29,732,163...29,754,276 JBrowse link
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 increases expression ISO Chlorpromazine results in increased expression of HMGCS1 mRNA CTD PMID:17052361 NCBI chr 2:53,379,457...53,399,807 JBrowse link
G Hmox1 heme oxygenase 1 increases expression
affects expression		 ISO
EXP		 Chlorpromazine results in increased expression of HMOX1 mRNA
Chlorpromazine affects the expression of HMOX1 mRNA		 CTD PMID:15924885 PMID:25596134 PMID:31324950 NCBI chr19:13,452,365...13,479,823 JBrowse link
G Hpn hepsin increases expression ISO Chlorpromazine results in increased expression of HPN mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 1:86,337,085...86,352,785 JBrowse link
G Hspa2 heat shock protein family A (Hsp70) member 2 increases expression
decreases expression		 EXP Chlorpromazine results in increased expression of HSPA2 mRNA
Chlorpromazine results in decreased expression of HSPA2 mRNA; Chlorpromazine results in decreased expression of HSPA2 protein		 CTD PMID:36751017 NCBI chr 6:100,864,172...100,866,946 JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression
decreases expression		 EXP Chlorpromazine results in increased expression of HSPB1 mRNA
Chlorpromazine results in decreased expression of HSPB1 mRNA		 CTD PMID:36751017 NCBI chr12:26,430,640...26,432,301 JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 increases expression EXP Chlorpromazine results in increased expression of HSPD1 mRNA CTD PMID:36751017 NCBI chr 9:64,073,610...64,084,332 JBrowse link
G Hspe1 heat shock protein family E (Hsp10) member 1 increases expression EXP Chlorpromazine results in increased expression of HSPE1 mRNA CTD PMID:36751017 NCBI chr 9:56,589,912...56,593,000 JBrowse link
G Ibsp integrin-binding sialoprotein decreases expression
multiple interactions		 EXP Chlorpromazine results in decreased expression of IBSP mRNA
herbimycin inhibits the reaction [Chlorpromazine results in decreased expression of IBSP mRNA]; U 0126 inhibits the reaction [Chlorpromazine results in decreased expression of IBSP mRNA]		 CTD PMID:16294319 NCBI chr14:5,439,825...5,452,570 JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO Chlorpromazine promotes the reaction [PAM2-CSK4 results in increased expression of IFNB1 mRNA] CTD PMID:32796029 NCBI chr 5:108,066,650...108,067,487 JBrowse link
G Ifng interferon gamma multiple interactions ISO [Chlorpromazine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA CTD PMID:29594315 NCBI chr 7:55,789,180...55,793,216 JBrowse link
G Ifnlr1 interferon, lambda receptor 1 increases expression ISO Chlorpromazine results in increased expression of IFNLR1 mRNA CTD PMID:21683644 NCBI chr 5:147,919,547...147,942,328 JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 increases expression ISO Chlorpromazine results in increased expression of IGFBP1 mRNA CTD PMID:15924885 NCBI chr14:86,261,277...86,266,344 JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma increases expression ISO Chlorpromazine analog results in increased expression of IKBKG mRNA CTD PMID:15924885 NCBI chr  X:157,358,279...157,397,563 JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Chlorpromazine CTD PMID:19362101 NCBI chr 3:136,979,804...136,990,236 JBrowse link
G Il1b interleukin 1 beta decreases expression ISO Chlorpromazine results in decreased expression of IL1B mRNA CTD PMID:29594315 NCBI chr 3:137,030,200...137,036,581 JBrowse link
G Il2 interleukin 2 multiple interactions ISO [Chlorpromazine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA; Chlorpromazine inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK1 protein]; Chlorpromazine inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK3 protein] CTD PMID:11014349 PMID:29594315 NCBI chr 2:121,932,968...121,937,672 JBrowse link
G Il6 interleukin 6 multiple interactions ISO [IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Chlorpromazine CTD PMID:19362101 NCBI chr 4:5,889,999...5,894,575 JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Chlorpromazine results in increased expression of INHBE mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 7:65,061,531...65,064,519 JBrowse link
G Ins1 insulin 1 decreases secretion EXP Chlorpromazine results in decreased secretion of INS1 protein CTD PMID:18308779 NCBI chr 1:261,186,119...261,186,686 JBrowse link
G Insig2 insulin induced gene 2 decreases expression EXP Chlorpromazine results in decreased expression of INSIG2 mRNA CTD PMID:25596134 NCBI chr13:32,472,390...32,500,139 JBrowse link
G Irs2 insulin receptor substrate 2 multiple interactions EXP Chlorpromazine results in decreased expression of and results in decreased phosphorylation of IRS2 protein; Chlorpromazine results in decreased expression of and results in increased degradation of IRS2 protein CTD PMID:17512020 PMID:18308779 NCBI chr16:85,190,310...85,214,543 JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity		 ISO Chlorpromazine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Chlorpromazine results in decreased activity of KCNH2 protein		 CTD PMID:15071359 PMID:21158687 PMID:24052561 NCBI chr 4:11,719,357...11,751,424 JBrowse link
G Kcnn2 potassium calcium-activated channel subfamily N member 2 decreases activity EXP Chlorpromazine results in decreased activity of KCNN2 protein CTD PMID:10915830 NCBI chr18:40,004,693...40,445,043 JBrowse link
G Klf4 KLF transcription factor 4 multiple interactions
decreases expression		 ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of KLF4 mRNA
Chlorpromazine results in decreased expression of KLF4 mRNA		 CTD PMID:27344345 PMID:30703373 NCBI chr 5:75,074,107...75,079,182 JBrowse link
G Klkb1 kallikrein B1 multiple interactions ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of KLKB1 mRNA CTD PMID:27344345 NCBI chr16:46,958,634...46,982,054 JBrowse link
G Kng1 kininogen 1 multiple interactions ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of KNG1 mRNA CTD PMID:27344345 NCBI chr11:77,812,757...77,835,555 JBrowse link
G Lats1 large tumor suppressor kinase 1 increases phosphorylation ISO Chlorpromazine results in increased phosphorylation of LATS1 protein CTD PMID:30703373 NCBI chr 1:3,980,801...4,014,029 JBrowse link
G Ldhc lactate dehydrogenase C decreases activity
multiple interactions		 EXP Chlorpromazine results in decreased activity of LDHC protein
[Taurine co-treated with coenzyme Q10] inhibits the reaction [Chlorpromazine results in decreased activity of LDHC protein]; coenzyme Q10 inhibits the reaction [Chlorpromazine results in decreased activity of LDHC protein]; Taurine inhibits the reaction [Chlorpromazine results in decreased activity of LDHC protein]		 CTD PMID:33548410 NCBI chr 1:97,385,984...97,403,382 JBrowse link
G Ldlr low density lipoprotein receptor increases expression ISO Chlorpromazine results in increased expression of LDLR mRNA CTD PMID:17052361 NCBI chr 8:20,270,020...20,292,981 JBrowse link
G Lep leptin increases expression EXP Chlorpromazine results in increased expression of LEP protein CTD PMID:17512020 NCBI chr 4:58,626,529...58,640,663 JBrowse link
G Lss lanosterol synthase increases expression ISO Chlorpromazine results in increased expression of LSS mRNA CTD PMID:15342952 PMID:17175557 NCBI chr20:12,090,641...12,118,230 JBrowse link
G Map2 microtubule-associated protein 2 increases expression EXP Chlorpromazine results in increased expression of MAP2 mRNA CTD PMID:15079866 NCBI chr 9:75,173,038...75,431,606 JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO
EXP		 Chlorpromazine inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK1 protein]
MAPK1 affects the reaction [Chlorpromazine results in increased expression of EGR1]		 CTD PMID:11014349 PMID:20368687 NCBI chr11:97,462,025...97,529,193 JBrowse link
G Mapk14 mitogen activated protein kinase 14 decreases expression ISO Chlorpromazine analog results in decreased expression of MAPK14 mRNA CTD PMID:15924885 NCBI chr20:6,751,288...6,812,294 JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases expression
multiple interactions		 ISO
EXP		 Chlorpromazine analog results in decreased expression of MAPK3 mRNA
MAPK3 affects the reaction [Chlorpromazine results in increased expression of EGR1]
Chlorpromazine inhibits the reaction [IL2 protein results in increased phosphorylation of MAPK3 protein]		 CTD PMID:11014349 PMID:15924885 PMID:20368687 NCBI chr 1:190,797,189...190,803,411 JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO [Chlorpromazine co-treated with lipoteichoic acid] results in increased phosphorylation of MAPK8 protein; Chlorpromazine promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein]; TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipoteichoic acid] results in increased phosphorylation of MAPK8 protein]; TIRAP gene mutant form inhibits the reaction [Chlorpromazine promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein]] CTD PMID:23238562 NCBI chr16:8,645,171...8,728,225 JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 increases expression EXP Chlorpromazine results in increased expression of MAPKAPK2 mRNA CTD PMID:19441803 NCBI chr13:45,066,027...45,112,326 JBrowse link
G Mcm3 minichromosome maintenance complex component 3 decreases expression ISO Chlorpromazine analog results in decreased expression of MCM3 mRNA CTD PMID:15924885 NCBI chr 9:30,715,602...30,733,746 JBrowse link
G Mcm5 minichromosome maintenance complex component 5 decreases expression ISO Chlorpromazine analog results in decreased expression of MCM5 mRNA CTD PMID:15924885 NCBI chr19:13,488,813...13,510,131 JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression EXP Chlorpromazine results in increased expression of MDM2 mRNA CTD PMID:25596134 NCBI chr 7:55,176,558...55,201,757 JBrowse link
G Mitf melanocyte inducing transcription factor increases expression ISO Chlorpromazine results in increased expression of MITF protein CTD PMID:25449126 NCBI chr 4:131,965,676...132,177,790 JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO Chlorpromazine analog results in decreased expression of MKI67 mRNA CTD PMID:15924885 NCBI chr 1:199,926,150...199,952,847 JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Chlorpromazine inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased expression of MMP9 mRNA]; Chlorpromazine inhibits the reaction [FSL-1 lipoprotein, synthetic results in increased secretion of MMP9 protein] CTD PMID:25200491 NCBI chr 3:174,103,474...174,111,434 JBrowse link
G Msc musculin decreases expression EXP Chlorpromazine results in decreased expression of MSC mRNA CTD PMID:25596134 NCBI chr 5:4,547,335...4,553,206 JBrowse link
G Msh2 mutS homolog 2 decreases expression ISO Chlorpromazine results in decreased expression of MSH2 mRNA CTD PMID:15924885 NCBI chr 6:12,567,368...12,626,534 JBrowse link
G Mst1 macrophage stimulating 1 increases phosphorylation ISO Chlorpromazine results in increased phosphorylation of MST1 protein CTD PMID:30703373 NCBI chr 8:117,646,485...117,652,016 JBrowse link
G Mt1 metallothionein 1 increases expression EXP Chlorpromazine results in increased expression of MT1A mRNA CTD PMID:8128501 NCBI chr19:10,831,959...10,832,975 JBrowse link
G Mybl2 MYB proto-oncogene like 2 decreases expression ISO Chlorpromazine analog results in decreased expression of MYBL2 mRNA CTD PMID:15924885 NCBI chr 3:172,124,765...172,153,221 JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor decreases expression ISO Chlorpromazine results in decreased expression of MYC mRNA CTD PMID:30703373 NCBI chr 7:95,483,105...95,488,031 JBrowse link
G Nampt nicotinamide phosphoribosyltransferase increases expression EXP Chlorpromazine results in increased expression of NAMPT mRNA CTD PMID:25596134 NCBI chr 6:55,152,756...55,189,547 JBrowse link
G Nanog Nanog homeobox decreases expression ISO Chlorpromazine results in decreased expression of NANOG mRNA CTD PMID:30703373 NCBI chr 4:155,943,737...155,951,116 JBrowse link
G Ndufs3 NADH:ubiquinone oxidoreductase core subunit S3 decreases expression EXP Chlorpromazine results in decreased expression of NDUFS3 protein CTD PMID:19441803 NCBI chr 3:76,876,646...76,883,824 JBrowse link
G Nectin2 nectin cell adhesion molecule 2 multiple interactions ISO Chlorpromazine inhibits the reaction [Cadmium Chloride results in decreased expression of and affects the localization of NECTIN2 protein] CTD PMID:25046863 NCBI chr 1:79,372,123...79,407,379 JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 decreases expression EXP Chlorpromazine results in decreased expression of NEDD9 mRNA CTD PMID:25596134 NCBI chr17:23,289,793...23,468,026 JBrowse link
G Nefh neurofilament heavy chain affects expression EXP Chlorpromazine affects the expression of NEFH mRNA CTD PMID:31324950 NCBI chr14:84,044,428...84,054,413 JBrowse link
G Nfatc1 nuclear factor of activated T-cells 1 multiple interactions ISO Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA] CTD PMID:21869564 NCBI chr18:76,321,386...76,430,997 JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases expression
affects activity		 EXP Chlorpromazine results in decreased expression of NFE2L2 mRNA
Chlorpromazine affects the activity of NFE2L2 protein		 CTD PMID:25596134 NCBI chr 3:81,001,529...81,031,165 JBrowse link
G Ninj1 ninjurin 1 increases expression EXP Chlorpromazine results in increased expression of NINJ1 mRNA CTD PMID:25596134 NCBI chr17:15,659,208...15,668,115 JBrowse link
G Nppb natriuretic peptide B increases expression EXP Chlorpromazine results in increased expression of NPPB protein CTD PMID:36751017 NCBI chr 5:163,699,955...163,701,314 JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Chlorpromazine results in increased expression of NR0B2 mRNA CTD PMID:17175557 NCBI chr 5:145,779,294...145,782,609 JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 decreases expression EXP Chlorpromazine results in decreased expression of NR1H4 mRNA CTD PMID:27765674 PMID:28391356 NCBI chr 7:25,733,471...25,829,440 JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases expression
multiple interactions		 ISO Chlorpromazine analog results in increased expression of NR1I2 mRNA
[Chlorpromazine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA		 CTD PMID:15924885 PMID:17041008 NCBI chr11:75,965,717...76,006,733 JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity
increases expression
multiple interactions		 ISO Chlorpromazine results in increased activity of NR1I3 protein
Chlorpromazine results in increased expression of NR1I3 mRNA
[Chlorpromazine co-treated with Cholic Acids] affects the expression of NR1I3 mRNA; [Chlorpromazine results in increased activity of NR1I3 protein alternative form] which results in increased expression of CYP2B6 mRNA; Chlorpromazine inhibits the reaction [Androstenols inhibits the reaction [NR1I3 protein results in increased expression of CYP2B6 mRNA]]
NR1I3 protein affects the reaction [Chlorpromazine results in increased expression of CYP2B10 mRNA]; NR1I3 protein affects the reaction [Chlorpromazine results in increased expression of CYP3A11 mRNA]		 CTD PMID:10037683 PMID:12049174 PMID:12948398 PMID:17041008 PMID:22310298 More... NCBI chr13:86,165,327...86,170,362 JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO Chlorpromazine inhibits the reaction [Corticosterone results in increased activity of NR3C1 protein] CTD PMID:16581232 NCBI chr18:31,522,783...31,644,508 JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Chlorpromazine results in increased expression of NUPR1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 1:190,643,866...190,645,901 JBrowse link
G Orc1 origin recognition complex, subunit 1 decreases expression ISO Chlorpromazine analog results in decreased expression of ORC1 mRNA CTD PMID:15924885 NCBI chr 5:128,552,975...128,581,943 JBrowse link
G Orm1 orosomucoid 1 affects binding
multiple interactions		 ISO Chlorpromazine binds to ORM1 protein alternative form
Chlorpromazine inhibits the reaction [Warfarin binds to ORM1 protein alternative form]		 CTD PMID:8946472 NCBI chr 5:81,788,509...81,791,661 JBrowse link
G Pdia2 protein disulfide isomerase family A, member 2 increases expression ISO Chlorpromazine analog results in increased expression of PDIA2 mRNA CTD PMID:15924885 NCBI chr10:15,215,824...15,218,937 JBrowse link
G Pdia5 protein disulfide isomerase family A, member 5 decreases expression EXP Chlorpromazine results in decreased expression of PDIA5 mRNA CTD PMID:25596134 NCBI chr11:65,272,152...65,359,087 JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 increases expression EXP Chlorpromazine results in increased expression of PDK1 mRNA CTD PMID:25596134 NCBI chr 3:77,113,464...77,144,145 JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 increases expression EXP Chlorpromazine results in increased expression of PDK4 mRNA CTD PMID:25596134 NCBI chr 4:34,558,327...34,568,329 JBrowse link
G Phyh phytanoyl-CoA 2-hydroxylase increases expression ISO Chlorpromazine results in increased expression of PHYH mRNA CTD PMID:15342952 NCBI chr17:73,329,461...73,346,359 JBrowse link
G Pias1 protein inhibitor of activated STAT, 1 increases expression ISO Chlorpromazine results in increased expression of PIAS1 mRNA CTD PMID:21683644 NCBI chr 8:63,338,150...63,451,670 JBrowse link
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase increases expression ISO Chlorpromazine analog results in increased expression of PIM1 mRNA CTD PMID:15924885 NCBI chr20:7,556,496...7,560,747 JBrowse link
G Pir pirin decreases expression EXP Chlorpromazine results in decreased expression of PIR mRNA CTD PMID:25596134 NCBI chr  X:33,740,428...33,851,049 JBrowse link
G Plin2 perilipin 2 increases expression EXP Chlorpromazine results in increased expression of PLIN2 mRNA CTD PMID:25596134 NCBI chr 5:106,202,634...106,258,748 JBrowse link
G Pmepa1 prostate transmembrane protein, androgen induced 1 decreases expression EXP Chlorpromazine results in decreased expression of PMEPA1 mRNA CTD PMID:25596134 NCBI chr 3:162,011,884...162,060,343 JBrowse link
G Pola1 DNA polymerase alpha 1, catalytic subunit decreases expression ISO Chlorpromazine analog results in decreased expression of POLA1 mRNA CTD PMID:15924885 NCBI chr  X:62,028,475...62,342,455 JBrowse link
G Pold4 DNA polymerase delta 4, accessory subunit increases expression ISO Chlorpromazine analog results in increased expression of POLD4 mRNA CTD PMID:15924885 NCBI chr 1:201,526,591...201,528,406 JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases expression ISO Chlorpromazine results in decreased expression of POU5F1 mRNA CTD PMID:30703373 NCBI chr20:3,227,836...3,232,598 JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects activity EXP Chlorpromazine affects the activity of PPARG protein CTD PMID:25596134 NCBI chr 4:150,095,743...150,221,104 JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression EXP Chlorpromazine results in increased expression of PPP1R15A mRNA CTD PMID:25596134 NCBI chr 1:105,136,521...105,139,596 JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 decreases phosphorylation EXP Chlorpromazine results in decreased phosphorylation of PRKAA1 protein CTD PMID:17512020 NCBI chr 2:55,967,766...56,003,450 JBrowse link
G Prl prolactin increases expression ISO Chlorpromazine results in increased expression of PRL protein CTD PMID:718334 PMID:996201 NCBI chr17:38,287,355...38,298,234 JBrowse link
G Rara retinoic acid receptor, alpha decreases expression EXP Chlorpromazine results in decreased expression of RARA mRNA CTD PMID:18246545 NCBI chr10:83,883,490...83,928,932 JBrowse link
G Rnd1 Rho family GTPase 1 decreases expression EXP Chlorpromazine results in decreased expression of RND1 mRNA CTD PMID:25596134 NCBI chr 7:129,821,311...129,828,385 JBrowse link
G Rnd3 Rho family GTPase 3 decreases expression EXP Chlorpromazine results in decreased expression of RND3 mRNA CTD PMID:25596134 NCBI chr 3:55,981,142...55,998,494 JBrowse link
G Rnf121 ring finger protein 121 decreases expression EXP Chlorpromazine results in decreased expression of RNF121 mRNA CTD PMID:25596134 NCBI chr 1:156,377,368...156,439,936 JBrowse link
G Runx1 RUNX family transcription factor 1 increases expression EXP Chlorpromazine results in increased expression of RUNX1 mRNA CTD PMID:25596134 NCBI chr11:45,325,778...45,560,300 JBrowse link
G Rxrg retinoid X receptor gamma affects response to substance ISO RXRG protein affects the susceptibility to Chlorpromazine CTD PMID:10336693 NCBI chr13:82,276,330...82,318,097 JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 increases expression EXP Chlorpromazine results in increased expression of SAT1 mRNA CTD PMID:25596134 NCBI chr  X:44,008,089...44,011,376 JBrowse link
G Sc5d sterol-C5-desaturase increases expression ISO Chlorpromazine results in increased expression of SC5D mRNA CTD PMID:17052361 NCBI chr 8:42,629,649...42,641,257 JBrowse link
G Serpina3n serpin family A member 3N increases expression ISO Chlorpromazine results in increased expression of SERPINA3 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 6:123,323,623...123,331,181 JBrowse link
G Serpinh1 serpin family H member 1 increases expression ISO Chlorpromazine results in increased expression of SERPINH1 mRNA CTD PMID:35708773 NCBI chr 1:153,643,500...153,650,853 JBrowse link
G Sesn1 sestrin 1 decreases expression EXP Chlorpromazine results in decreased expression of SESN1 mRNA CTD PMID:25596134 NCBI chr20:46,876,918...46,970,010 JBrowse link
G Sik1 salt-inducible kinase 1 decreases expression EXP Chlorpromazine results in decreased expression of SIK1 mRNA CTD PMID:25596134 NCBI chr20:9,947,104...9,958,729 JBrowse link
G Slc10a1 solute carrier family 10 member 1 decreases expression
increases expression		 EXP
ISO		 Chlorpromazine results in decreased expression of SLC10A1 mRNA
Chlorpromazine results in increased expression of SLC10A1 mRNA		 CTD PMID:27765674 PMID:28391356 PMID:35708773 NCBI chr 6:100,613,045...100,626,670 JBrowse link
G Slc12a8 solute carrier family 12, member 8 increases expression EXP Chlorpromazine results in increased expression of SLC12A8 mRNA CTD PMID:25596134 NCBI chr11:67,116,876...67,266,548 JBrowse link
G Slc19a1 solute carrier family 19 member 1 multiple interactions
decreases activity		 EXP Chlorpromazine inhibits the reaction [SLC19A1 protein results in increased uptake of Methotrexate]
Chlorpromazine results in decreased activity of SLC19A1 protein		 CTD PMID:17482559 NCBI chr20:11,584,410...11,602,429 JBrowse link
G Slc1a5 solute carrier family 1 member 5 increases expression EXP Chlorpromazine results in increased expression of SLC1A5 mRNA CTD PMID:25596134 NCBI chr 1:77,456,849...77,470,952 JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Chlorpromazine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019 JBrowse link
G Slc22a7 solute carrier family 22 member 7 multiple interactions ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of SLC22A7 mRNA CTD PMID:27344345 NCBI chr 9:14,547,073...14,554,354 JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression ISO Chlorpromazine results in decreased expression of SLC2A3 mRNA CTD PMID:15342952 NCBI chr 4:157,632,887...157,698,034 JBrowse link
G Slc31a1 solute carrier family 31 member 1 multiple interactions ISO Chlorpromazine inhibits the reaction [Copper affects the localization of SLC31A1 protein] CTD PMID:12501239 NCBI chr 5:75,814,744...75,844,241 JBrowse link
G Slc3a2 solute carrier family 3 member 2 increases expression EXP Chlorpromazine results in increased expression of SLC3A2 mRNA CTD PMID:25596134 NCBI chr 1:215,033,601...215,048,064 JBrowse link
G Slc51b SLC51 subunit beta multiple interactions ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of SLC51B mRNA CTD PMID:27344345 NCBI chr 8:65,931,891...65,939,953 JBrowse link
G Slc6a6 solute carrier family 6 member 6 increases expression EXP Chlorpromazine results in increased expression of SLC6A6 mRNA CTD PMID:25596134 NCBI chr 4:124,195,186...124,268,880 JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 decreases expression EXP Chlorpromazine results in decreased expression of SLCO2B1 mRNA CTD PMID:25596134 NCBI chr 1:153,959,288...154,007,294 JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP Chlorpromazine inhibits the reaction [Copper inhibits the reaction [Trientine results in decreased activity of SOD1 protein]] CTD PMID:22362149 NCBI chr11:42,942,742...42,948,399 JBrowse link
G Sox2 SRY-box transcription factor 2 decreases expression ISO Chlorpromazine results in decreased expression of SOX2 mRNA CTD PMID:30703373 NCBI chr 2:117,536,929...117,539,340 JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of SPP1 mRNA CTD PMID:27344345 NCBI chr14:5,613,569...5,620,695 JBrowse link
G Spsb1 splA/ryanodine receptor domain and SOCS box containing 1 increases expression EXP Chlorpromazine results in increased expression of SPSB1 mRNA CTD PMID:25596134 NCBI chr 5:160,358,292...160,418,541 JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions EXP Chlorpromazine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased phosphorylation of SRC protein] CTD PMID:29702141 NCBI chr 3:166,511,616...166,559,463 JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 multiple interactions ISO Chlorpromazine results in increased cleavage of and results in increased activity of SREBF2 protein CTD PMID:17052361 NCBI chr 7:115,542,774...115,600,945 JBrowse link
G Strbp spermatid perinuclear RNA binding protein increases expression EXP Chlorpromazine results in increased expression of STRBP mRNA CTD PMID:25596134 NCBI chr 3:21,328,310...21,467,753 JBrowse link
G Sts steroid sulfatase multiple interactions ISO Chlorpromazine inhibits the reaction [Tretinoin results in increased activity of STS protein] CTD PMID:16178010 NCBI chr  X:46,102,524...46,110,868 JBrowse link
G Tagln transgelin decreases expression ISO Chlorpromazine results in decreased expression of TAGLN mRNA CTD PMID:17175557 NCBI chr 8:55,121,647...55,127,121 JBrowse link
G Tf transferrin affects localization ISO Chlorpromazine affects the localization of TF protein CTD PMID:12501239 NCBI chr 8:103,789,780...103,816,487 JBrowse link
G Tfdp1 transcription factor Dp-1 decreases expression ISO Chlorpromazine analog results in decreased expression of TFDP1 mRNA CTD PMID:15924885 NCBI chr16:82,864,220...82,903,166 JBrowse link
G Tiparp TCDD-inducible poly(ADP-ribose) polymerase increases expression EXP Chlorpromazine results in increased expression of TIPARP mRNA CTD PMID:25596134 NCBI chr 2:149,753,682...149,780,327 JBrowse link
G Tirap TIR domain containing adaptor protein multiple interactions ISO TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TNF protein]; TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipoteichoic acid] results in increased expression of TNF protein]; TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipoteichoic acid] results in increased phosphorylation of MAPK8 protein]; TIRAP gene mutant form inhibits the reaction [Chlorpromazine promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein]]; TIRAP protein results in increased susceptibility to [Chlorpromazine co-treated with lipopolysaccharide, Escherichia coli O111 B4]; TIRAP protein results in increased susceptibility to [Chlorpromazine co-treated with lipoteichoic acid] CTD PMID:23238562 NCBI chr 8:41,789,557...41,805,903 JBrowse link
G Tnf tumor necrosis factor decreases expression
increases response to substance
multiple interactions		 ISO Chlorpromazine analog results in decreased expression of TNF protein; Chlorpromazine results in decreased expression of TNF mRNA
TNF protein results in increased susceptibility to Chlorpromazine
[Chlorpromazine co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TNF protein; [Chlorpromazine co-treated with lipoteichoic acid] results in increased expression of TNF protein; Chlorpromazine inhibits the reaction [[hydroquinone results in increased expression of TNF protein] which results in increased susceptibility to Methacholine Chloride]; Chlorpromazine inhibits the reaction [hydroquinone results in increased expression of TNF protein]; pyrazolanthrone inhibits the reaction [TNF protein results in increased susceptibility to Chlorpromazine]; TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of TNF protein]; TIRAP gene mutant form inhibits the reaction [[Chlorpromazine co-treated with lipoteichoic acid] results in increased expression of TNF protein]
[IL6 protein co-treated with IL1A protein co-treated with TNF protein co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased susceptibility to Chlorpromazine; Chlorpromazine results in decreased expression of and results in decreased activity of TNF protein		 CTD PMID:8550079 PMID:15052360 PMID:19362101 PMID:20371967 PMID:22414385 More... NCBI chr20:3,626,685...3,629,303 JBrowse link
G Tnfaip8 TNF alpha induced protein 8 increases expression EXP Chlorpromazine results in increased expression of TNFAIP8 mRNA CTD PMID:25596134 NCBI chr18:45,370,334...45,486,036 JBrowse link
G Tnfrsf14 TNF receptor superfamily member 14 increases expression ISO Chlorpromazine analog results in increased expression of TNFRSF14 mRNA CTD PMID:15924885 NCBI chr 5:170,768,413...170,776,749 JBrowse link
G Tnfsf11 TNF superfamily member 11 decreases activity
multiple interactions		 ISO Chlorpromazine results in decreased activity of TNFSF11; Chlorpromazine results in decreased activity of TNFSF11 protein
Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of ACP5 mRNA]; Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of CALCR mRNA]; Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of CAR2 mRNA]; Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of CTSK mRNA]; Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of DCSTAMP mRNA]; Chlorpromazine inhibits the reaction [TNFSF11 protein results in increased expression of NFATC1 mRNA]		 CTD PMID:21869564 NCBI chr15:60,083,008...60,114,479 JBrowse link
G Tp53 tumor protein p53 affects activity EXP Chlorpromazine affects the activity of TP53 protein CTD PMID:25596134 NCBI chr10:54,798,871...54,810,300 JBrowse link
G Trafd1 TRAF type zinc finger domain containing 1 decreases expression EXP Chlorpromazine results in decreased expression of TRAFD1 mRNA CTD PMID:25596134 NCBI chr12:40,826,251...40,840,169 JBrowse link
G Tuba1a tubulin, alpha 1A decreases expression ISO Chlorpromazine results in decreased expression of TUBA1A mRNA CTD PMID:27015953 NCBI chr 7:131,992,151...131,996,850 JBrowse link
G Txn1 thioredoxin 1 decreases expression EXP Chlorpromazine results in decreased expression of TXN1 mRNA CTD PMID:25596134 NCBI chr 5:77,507,455...77,519,685 JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions ISO [Chlorpromazine co-treated with Cholic Acids] affects the expression of TXNRD1 mRNA CTD PMID:27344345 NCBI chr 7:22,717,620...22,802,553 JBrowse link
G Tyr tyrosinase increases expression ISO Chlorpromazine results in increased expression of TYR protein CTD PMID:25449126 NCBI chr 1:150,527,687...150,622,857 JBrowse link
G Ung uracil-DNA glycosylase decreases expression ISO Chlorpromazine analog results in decreased expression of UNG mRNA CTD PMID:15924885 NCBI chr12:48,145,838...48,154,789 JBrowse link
G Unkl unk like zinc finger decreases expression EXP Chlorpromazine results in decreased expression of UNKL mRNA CTD PMID:25596134 NCBI chr10:14,206,125...14,252,226 JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO Chlorpromazine analog results in increased expression of VEGFA mRNA CTD PMID:15924885 NCBI chr 9:22,452,854...22,468,194 JBrowse link
G Vegfb vascular endothelial growth factor B increases expression EXP Chlorpromazine results in increased expression of VEGFB mRNA CTD PMID:25596134 NCBI chr 1:213,601,570...213,607,254 JBrowse link
G Wars1 tryptophanyl-tRNA synthetase 1 increases expression EXP Chlorpromazine results in increased expression of WARS1 mRNA CTD PMID:25596134 NCBI chr 6:127,776,088...127,807,273 JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Chlorpromazine results in increased expression of WIPI1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr10:95,042,451...95,079,679 JBrowse link
G Xbp1 X-box binding protein 1 affects activity
decreases expression		 EXP Chlorpromazine affects the activity of XBP1 protein
Chlorpromazine results in decreased expression of XBP1 mRNA		 CTD PMID:25596134 NCBI chr14:84,604,623...84,609,707 JBrowse link
G Xpc XPC complex subunit, DNA damage recognition and repair factor decreases expression EXP Chlorpromazine results in decreased expression of XPC mRNA CTD PMID:25596134 NCBI chr 4:123,993,670...124,020,922 JBrowse link
G Xrcc4 X-ray repair cross complementing 4 decreases expression ISO Chlorpromazine results in decreased expression of XRCC4 mRNA CTD PMID:15924885 NCBI chr 2:20,948,464...21,197,705 JBrowse link
G Yap1 Yes1 associated transcriptional regulator multiple interactions ISO Chlorpromazine results in decreased expression of and results in increased phosphorylation of and affects the localization of YAP1 protein CTD PMID:30703373 NCBI chr 8:5,095,705...5,166,808 JBrowse link
clidinium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO clidinium inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019 JBrowse link
clomiphene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd2 abhydrolase domain containing 2, acylglycerol lipase decreases expression ISO Clomiphene results in decreased expression of ABHD2 mRNA CTD PMID:26865669 NCBI chr 1:142,626,748...142,707,892 JBrowse link
G Ar androgen receptor affects binding
multiple interactions		 EXP
ISO		 Clomiphene binds to AR protein
Clomiphene binds to and results in decreased activity of AR protein; Clomiphene inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]		 CTD PMID:14565775 PMID:25752796 PMID:33049310 NCBI chr  X:63,104,771...63,273,934 JBrowse link
G Car12 carbonic anhydrase 12 decreases expression ISO Clomiphene results in decreased expression of CA12 mRNA CTD PMID:26865669 NCBI chr 8:67,274,739...67,330,428 JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Clomiphene results in decreased expression of CCND1 mRNA CTD PMID:26865669 NCBI chr 1:209,518,288...209,527,986 JBrowse link
G Ccng2 cyclin G2 increases expression ISO Clomiphene results in increased expression of CCNG2 mRNA CTD PMID:26865669 NCBI chr14:15,088,694...15,097,190 JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression ISO Clomiphene results in decreased expression of CXCL12 mRNA CTD PMID:26865669 NCBI chr 4:152,060,781...152,073,628 JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Clomiphene results in decreased activity of CYP1A1 protein CTD PMID:33814510 NCBI chr 8:66,991,940...66,998,014 JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO Clomiphene results in decreased activity of CYP1B1 protein CTD PMID:33814510 NCBI chr 6:21,093,927...21,103,091 JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [Clomiphene results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA CTD PMID:25455453 NCBI chr12:14,321,771...14,343,886 JBrowse link
G Dkk1 dickkopf WNT signaling pathway inhibitor 1 decreases expression ISO Clomiphene results in decreased expression of DKK1 protein CTD PMID:21851939 NCBI chr 1:237,794,969...237,798,650 JBrowse link
G Efna1 ephrin A1 increases expression ISO Clomiphene results in increased expression of EFNA1 mRNA CTD PMID:26865669 NCBI chr 2:174,681,676...174,689,061 JBrowse link
G Egr3 early growth response 3 decreases expression ISO Clomiphene results in decreased expression of EGR3 mRNA CTD PMID:26865669 NCBI chr15:51,560,482...51,565,778 JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
affects binding		 ISO Clomiphene binds to and results in decreased activity of ESR1 protein; Clomiphene inhibits the reaction [16 alpha-iodoestradiol binds to ESR1 protein]; Clomiphene promotes the reaction [ESR1 protein alternative form binds to ESR1 protein alternative form]
Clomiphene binds to ESR1 protein		 CTD PMID:9048584 PMID:15521089 PMID:19233257 PMID:25012808 PMID:25752796 More... NCBI chr 1:43,511,685...43,904,454 JBrowse link
G Esr2 estrogen receptor 2 increases activity
affects binding
multiple interactions		 EXP
ISO		 Clomiphene results in increased activity of ESR2 protein
Clomiphene binds to Esr2 protein
Clomiphene binds to and results in decreased activity of ESR2 protein
Clomiphene binds to ESR2 protein
Clomiphene inhibits the reaction [16 alpha-iodoestradiol binds to ESR2 protein]		 CTD
RGD		 PMID:9048584 PMID:12224631 PMID:19211805 PMID:25752796 PMID:9048584 RGD:8694130 NCBI chr 6:100,589,553...100,645,240 JBrowse link
G F3 coagulation factor III, tissue factor increases expression ISO Clomiphene results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 2:212,511,675...212,523,375 JBrowse link
G F5 coagulation factor V affects response to substance ISO F5 gene polymorphism affects the susceptibility to Clomiphene CTD PMID:19371211 NCBI chr13:79,046,657...79,116,247 JBrowse link
G Foxc1 forkhead box C1 decreases expression ISO Clomiphene results in decreased expression of FOXC1 mRNA CTD PMID:26865669 NCBI chr17:32,631,379...32,635,361 JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions
increases expression		 ISO Clomiphene promotes the reaction [Alcohols results in increased expression of FSHB protein]
Clomiphene results in increased expression of FSHB protein		 CTD PMID:1915937 PMID:8590623 NCBI chr 3:114,003,262...114,007,072 JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 multiple interactions ISO Clomiphene inhibits the reaction [Estradiol promotes the reaction [GNRH1 protein results in increased secretion of PRL protein]] CTD PMID:17054466 NCBI chr15:41,972,482...41,976,690 JBrowse link
G Hoxa10 homeobox A10 decreases expression ISO Clomiphene results in decreased expression of HOXA10 mRNA; Clomiphene results in decreased expression of HOXA10 protein CTD PMID:26603317 NCBI chr 4:81,331,591...81,340,878 JBrowse link
G Id3 inhibitor of DNA binding 3 increases expression ISO Clomiphene results in increased expression of ID3 mRNA CTD PMID:26865669 NCBI chr 5:153,656,253...153,657,860 JBrowse link
G Itgb3 integrin subunit beta 3 decreases expression ISO Clomiphene results in decreased expression of ITGB3 protein
Clomiphene results in decreased expression of ITGB3 mRNA; Clomiphene results in decreased expression of ITGB3 protein		 CTD PMID:15749485 PMID:26603317 NCBI chr10:90,009,927...90,067,787 JBrowse link
G Iyd iodotyrosine deiodinase multiple interactions ISO Clomiphene inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine] CTD PMID:33352258 NCBI chr 1:42,410,099...42,425,414 JBrowse link
G Jak2 Janus kinase 2 decreases expression ISO Clomiphene results in decreased expression of JAK2 mRNA CTD PMID:26865669 NCBI chr 1:236,408,905...236,468,769 JBrowse link
G Kynu kynureninase increases expression ISO Clomiphene results in increased expression of KYNU mRNA CTD PMID:26865669 NCBI chr 3:48,188,286...48,338,996 JBrowse link
G Lhb luteinizing hormone subunit beta increases secretion
multiple interactions		 ISO Clomiphene results in increased secretion of LHB protein
Clomiphene promotes the reaction [Alcohols results in increased expression of LHB protein]; PRL protein inhibits the reaction [Clomiphene results in increased secretion of LHB protein]		 CTD PMID:3891423 PMID:8590623 NCBI chr 1:105,037,457...105,038,446 JBrowse link
G Lif LIF, interleukin 6 family cytokine increases expression
decreases expression		 ISO Clomiphene results in increased expression of LIF mRNA
Clomiphene results in decreased expression of LIF mRNA; Clomiphene results in decreased expression of LIF protein		 CTD PMID:21851939 PMID:26603317 NCBI chr14:83,354,602...83,364,053 JBrowse link
G Myb MYB proto-oncogene, transcription factor decreases expression ISO Clomiphene results in decreased expression of MYB mRNA CTD PMID:26865669 NCBI chr 1:15,939,771...15,973,367 JBrowse link
G Mybl1 MYB proto-oncogene like 1 decreases expression ISO Clomiphene results in decreased expression of MYBL1 mRNA CTD PMID:26865669 NCBI chr 5:9,582,905...9,618,179 JBrowse link
G Nmrk1 nicotinamide riboside kinase 1 decreases expression ISO Clomiphene results in decreased expression of NMRK1 mRNA CTD PMID:26865669 NCBI chr 1:225,475,975...225,503,414 JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions		 ISO Clomiphene results in increased activity of NR1I2 protein
Clomiphene binds to and results in increased activity of NR1I2 protein
[Clomiphene results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; Clomiphene binds to and results in increased activity of NR1I2 protein		 CTD PMID:25455453 PMID:33049310 NCBI chr11:75,965,717...76,006,733 JBrowse link
G Olfm1 olfactomedin 1 decreases expression ISO Clomiphene results in decreased expression of OLFM1 mRNA CTD PMID:26865669 NCBI chr 3:11,520,522...11,558,240 JBrowse link
G Pdzk1 PDZ domain containing 1 decreases expression ISO Clomiphene results in decreased expression of PDZK1 mRNA CTD PMID:26865669 NCBI chr 2:184,376,161...184,407,514 JBrowse link
G Pgr progesterone receptor increases expression
multiple interactions		 ISO Clomiphene results in increased expression of PGR protein
Clomiphene binds to and results in decreased activity of PGR protein		 CTD PMID:15749485 PMID:25752796 NCBI chr 8:14,354,398...14,413,271 JBrowse link
G Pik3r3 phosphoinositide-3-kinase regulatory subunit 3 increases expression ISO Clomiphene results in increased expression of PIK3R3 mRNA CTD PMID:26865669 NCBI chr 5:134,936,790...135,009,303 JBrowse link
G Prkce protein kinase C, epsilon affects localization ISO Clomiphene affects the localization of PRKCE protein CTD PMID:9714066 NCBI chr 6:13,718,050...14,204,931 JBrowse link
G Prl prolactin multiple interactions ISO Clomiphene inhibits the reaction [Estradiol promotes the reaction [GNRH1 protein results in increased secretion of PRL protein]]; Clomiphene inhibits the reaction [Estradiol results in increased secretion of PRL protein]; PRL protein inhibits the reaction [Clomiphene results in increased secretion of LHB protein] CTD PMID:3891423 PMID:17054466 NCBI chr17:38,287,355...38,298,234 JBrowse link
G Prss23 serine protease 23 decreases expression ISO Clomiphene results in decreased expression of PRSS23 mRNA CTD PMID:26865669 NCBI chr 1:143,402,725...143,422,182 JBrowse link
G Ptges prostaglandin E synthase decreases expression ISO Clomiphene results in decreased expression of PTGES mRNA CTD PMID:26865669 NCBI chr 3:14,177,892...14,189,236 JBrowse link
G Rbbp8 RB binding protein 8, endonuclease decreases expression ISO Clomiphene results in decreased expression of RBBP8 mRNA CTD PMID:26865669 NCBI chr18:3,198,188...3,263,643 JBrowse link
G Rcl1 RNA terminal phosphate cyclase-like 1 decreases expression ISO Clomiphene results in decreased expression of RCL1 mRNA CTD PMID:26865669 NCBI chr 1:236,238,078...236,282,597 JBrowse link
G Ret ret proto-oncogene decreases expression ISO Clomiphene results in decreased expression of RET mRNA CTD PMID:26865669 NCBI chr 4:152,998,344...153,040,556 JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 decreases expression ISO Clomiphene results in decreased expression of SGK1 mRNA CTD PMID:26865669 NCBI chr 1:24,799,391...24,916,886 JBrowse link
G Sgk3 serum/glucocorticoid regulated kinase family, member 3 decreases expression ISO Clomiphene results in decreased expression of SGK3 mRNA CTD PMID:26865669 NCBI chr 5:14,128,628...14,255,099 JBrowse link
G Shbg sex hormone binding globulin affects binding ISO Clomiphene binds to SHBG protein CTD PMID:25349334 NCBI chr10:54,332,939...54,350,409 JBrowse link
G Siah2 siah E3 ubiquitin protein ligase 2 decreases expression ISO Clomiphene results in decreased expression of SIAH2 mRNA CTD PMID:26865669 NCBI chr 2:145,063,847...145,081,675 JBrowse link
G Smox spermine oxidase decreases expression ISO Clomiphene results in decreased expression of SMOX mRNA CTD PMID:26865669 NCBI chr 3:118,731,814...118,767,242 JBrowse link
G Ssbp2 single-stranded DNA binding protein 2 increases expression ISO Clomiphene results in increased expression of SSBP2 mRNA CTD PMID:26865669 NCBI chr 2:22,650,488...22,938,669 JBrowse link
G Svil supervillin decreases expression ISO Clomiphene results in decreased expression of SVIL mRNA CTD PMID:26865669 NCBI chr17:52,648,502...52,844,114 JBrowse link
G Tfap2a transcription factor AP-2 alpha increases expression ISO Clomiphene results in increased expression of TFAP2A mRNA CTD PMID:26865669 NCBI chr17:24,230,064...24,253,219 JBrowse link
G Tfap2c transcription factor AP-2 gamma decreases expression ISO Clomiphene results in decreased expression of TFAP2C mRNA CTD PMID:26865669 NCBI chr 3:161,315,114...161,322,998 JBrowse link
G Tfpi tissue factor pathway inhibitor increases expression ISO Clomiphene results in increased expression of TFPI mRNA CTD PMID:26865669 NCBI chr 3:89,939,862...89,989,253 JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Clomiphene binds to and results in increased activity of THRA protein CTD PMID:33049310 NCBI chr10:84,198,141...84,225,659 JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO Clomiphene binds to and results in increased activity of THRB protein CTD PMID:33049310 NCBI chr15:10,115,954...10,465,231 JBrowse link
cyproheptadine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases expression EXP Cyproheptadine results in increased expression of CASP3 protein CTD PMID:33675893 NCBI chr16:52,395,539...52,413,794 JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO Cyproheptadine results in decreased activity of CYP1A1 protein CTD PMID:33814510 NCBI chr 8:66,991,940...66,998,014 JBrowse link
G Gh1 growth hormone 1 increases expression ISO Cyproheptadine results in increased expression of GH1 protein CTD PMID:642945 NCBI chr10:91,727,883...91,729,860 JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO Cyproheptadine results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:110,076,710...110,103,665 JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A multiple interactions ISO Cyproheptadine binds to and results in decreased activity of HTR2A protein CTD PMID:17031071 NCBI chr15:56,360,647...56,428,703 JBrowse link
G Htr7 5-hydroxytryptamine receptor 7 affects binding
multiple interactions		 ISO Cyproheptadine binds to HTR7 protein
Cyproheptadine inhibits the reaction [Risperidone binds to and results in decreased activity of HTR7 protein]		 CTD PMID:20827463 NCBI chr 1:243,049,064...243,173,636 JBrowse link
G Il6 interleukin 6 decreases expression EXP Cyproheptadine results in decreased expression of IL6 protein CTD PMID:33675893 NCBI chr 4:5,889,999...5,894,575 JBrowse link
G Kcnn2 potassium calcium-activated channel subfamily N member 2 decreases activity EXP Cyproheptadine results in decreased activity of KCNN2 protein CTD PMID:10915830 NCBI chr18:40,004,693...40,445,043 JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases expression EXP Cyproheptadine results in decreased expression of NFKB1 protein CTD PMID:33675893 NCBI chr 2:226,689,745...226,805,897 JBrowse link
G Pomc proopiomelanocortin decreases secretion ISO Cyproheptadine results in decreased secretion of POMC protein CTD PMID:642945 NCBI chr 6:32,659,137...32,665,175 JBrowse link
G Prl prolactin decreases secretion ISO Cyproheptadine results in decreased secretion of PRL protein CTD PMID:642945 NCBI chr17:38,287,355...38,298,234 JBrowse link
G Sirt1 sirtuin 1 increases expression EXP Cyproheptadine results in increased expression of SIRT1 protein CTD PMID:33675893 NCBI chr20:25,305,953...25,328,000 JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Cyproheptadine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019 JBrowse link
G Slc22a5 solute carrier family 22 member 5 multiple interactions ISO Cyproheptadine affects the reaction [SLC22A5 gene mutant form affects the transport of and affects the abundance of Pyrilamine] CTD PMID:19821448 NCBI chr10:38,008,303...38,035,474 JBrowse link
dextropropoxyphene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A affects response to substance ISO ABCB1A protein affects the susceptibility to Dextropropoxyphene CTD PMID:15502009 NCBI chr 4:26,312,403...26,488,456 JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B affects response to substance ISO ABCB1B protein affects the susceptibility to Dextropropoxyphene CTD PMID:15502009 NCBI chr 4:26,197,706...26,280,156 JBrowse link
G Ces1d carboxylesterase 1D affects binding ISO Dextropropoxyphene binds to CES1 protein CTD PMID:10381793 NCBI chr19:30,046,494...30,085,039 JBrowse link
G Ces2h carboxylesterase 2H affects binding ISO Dextropropoxyphene binds to CES2 protein CTD PMID:10381793 NCBI chr19:32,974,242...32,988,842 JBrowse link
G Oprd1 opioid receptor, delta 1 multiple interactions
affects binding		 EXP [Dextropropoxyphene binds to OPRD1 protein] which results in decreased uptake of Norepinephrine; [Dextropropoxyphene binds to OPRD1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 NCBI chr 5:149,590,244...149,624,999 JBrowse link
G Oprk1 opioid receptor, kappa 1 multiple interactions
affects binding		 EXP [Dextropropoxyphene binds to OPRK1 protein] which results in decreased uptake of Norepinephrine; [Dextropropoxyphene binds to OPRK1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 NCBI chr 5:18,657,866...18,675,671 JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions
affects binding		 EXP [Dextropropoxyphene binds to OPRM1 protein] which results in decreased uptake of Norepinephrine; [Dextropropoxyphene binds to OPRM1 protein] which results in decreased uptake of Serotonin CTD PMID:7562497 NCBI chr 1:45,565,371...45,818,722 JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Dextropropoxyphene inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019 JBrowse link
dicyclomine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Dicyclomine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:50,668,817...50,711,019 JBrowse link
diphenoxylate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tp53 tumor protein p53 affects activity ISO Diphenoxylate affects the activity of TP53 protein CTD PMID:35435491 NCBI chr10:54,798,871...54,810,300 JBrowse link
diphenylpyraline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hrh1 histamine receptor H 1 multiple interactions ISO diphenylpyraline binds to and results in increased activity of HRH1 protein; diphenylpyraline inhibits the reaction [Pyrilamine binds to HRH1 protein] CTD PMID:1912125 NCBI chr 4:149,120,511...149,204,267 JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO diphenylpyraline results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:11,719,357...11,751,424 JBrowse link
doxylamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Doxylamine results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:26,106,895...26,164,440 JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO Doxylamine binds to and results in increased activity of NR1I3 protein alternative form CTD PMID:20869355 NCBI chr13:86,165,327...86,170,362 JBrowse link
EPTC term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity EXP EPTC results in decreased activity of ACHE protein CTD PMID:14644616 NCBI chr12:25,042,882...25,050,608 JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member decreases activity ISO EPTC metabolite results in decreased activity of ALDH2 protein CTD PMID:10513990 NCBI chr12:40,610,244...40,643,220 JBrowse link
G Alox15 arachidonate 15-lipoxygenase affects response to substance ISO ALOX15 gene SNP affects the susceptibility to EPTC CTD PMID:22919386 NCBI chr10:55,559,060...55,567,535 JBrowse link
G Chrna3 cholinergic receptor nicotinic alpha 3 subunit multiple interactions EXP EPTC results in decreased activity of [CHRNA3 protein binds to CHRNB2 protein]; EPTC results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 8:55,401,668...55,415,165 JBrowse link
G Chrna4 cholinergic receptor nicotinic alpha 4 subunit multiple interactions EXP EPTC results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]; EPTC results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 3:168,136,246...168,157,839 JBrowse link
G Chrnb2 cholinergic receptor nicotinic beta 2 subunit multiple interactions EXP EPTC results in decreased activity of [CHRNA3 protein binds to CHRNB2 protein]; EPTC results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein] CTD PMID:14644616 NCBI chr 2:175,181,402...175,189,619 JBrowse link
G Chrnb4 cholinergic receptor nicotinic beta 4 subunit multiple interactions EXP EPTC results in decreased activity of [CHRNA3 protein binds to CHRNB4 protein]; EPTC results in decreased activity of [CHRNA4 protein binds to CHRNB4 protein] CTD PMID:14644616 NCBI chr 8:55,417,583...55,437,027 JBrowse link
fenpropidin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a2 aldehyde dehydrogenase 1 family, member A2 increases expression ISO fenpropidine results in increased expression of ALDH1A2 mRNA CTD PMID:34737147 NCBI chr 8:71,877,850...71,957,107 JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 increases expression ISO fenpropidine results in increased expression of CYP26A1 mRNA CTD PMID:34737147 NCBI chr 1:235,471,368...235,475,204 JBrowse link
G Msmo1 methylsterol monooxygenase 1 increases expression ISO fenpropidine results in increased expression of MSMO1 mRNA CTD PMID:34737147 NCBI chr16:24,980,680...24,997,927 JBrowse link
G Myh14 myosin heavy chain 14 decreases expression ISO fenpropidine results in decreased expression of MYH14 protein CTD PMID:34737147 NCBI chr 1:95,096,266...95,158,861 JBrowse link
G Myh6 myosin heavy chain 6 decreases expression ISO fenpropidine results in decreased expression of MYH6 mRNA CTD PMID:34737147 NCBI chr15:32,388,102...32,413,663 JBrowse link
G Nes nestin increases expression ISO fenpropidine results in increased expression of NES mRNA CTD PMID:34737147 NCBI chr 2:175,735,715...175,745,631 JBrowse link
G Nkx2-5 NK2 homeobox 5 decreases expression ISO fenpropidine results in decreased expression of NKX2-5 mRNA CTD PMID:34737147 NCBI chr10:16,844,888...16,851,458 JBrowse link
G Tfap2a transcription factor AP-2 alpha increases expression ISO fenpropidine results in increased expression of TFAP2A protein CTD PMID:34737147 NCBI chr17:24,230,064...24,253,219 JBrowse link
G Tubb3 tubulin, beta 3 class III increases expression ISO fenpropidine results in increased expression of TUBB3 mRNA CTD PMID:34737147 NCBI chr19:68,365,687...68,374,741 JBrowse link
iron(III) nitrilotriacetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO ferric nitrilotriacetate inhibits the reaction [Asbestos, Crocidolite results in increased expression of ABCB1 protein]; ferric nitrilotriacetate inhibits the reaction [Razoxane results in increased expression of ABCB1 protein] CTD PMID:18385176 NCBI chr 4:26,312,403...26,488,456 JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 increases expression ISO ferric nitrilotriacetate results in increased expression of ABCC1 mRNA CTD PMID:18617210 NCBI chr10:1,022,041...1,162,431 JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression ISO ferric nitrilotriacetate results in increased expression of ABCC2 mRNA CTD PMID:18617210 NCBI chr 1:252,613,875...252,672,459 JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 increases expression ISO ferric nitrilotriacetate results in increased expression of ABCC4 mRNA CTD PMID:18617210 NCBI chr15:101,948,387...102,182,912 JBrowse link
G Anxa2 annexin A2 increases expression EXP ferric nitrilotriacetate results in increased expression of ANXA2 mRNA CTD PMID:10854235 NCBI chr 8:78,986,252...79,022,638 JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression EXP ferric nitrilotriacetate results in increased expression of BAX mRNA CTD PMID:23208426 NCBI chr 1:105,076,472...105,081,906 JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression EXP ferric nitrilotriacetate results in increased expression of BBC3 mRNA CTD PMID:23208426 NCBI chr 1:86,141,450...86,150,666 JBrowse link
G Bik BCL2-interacting killer increases expression EXP ferric nitrilotriacetate results in increased expression of BIK mRNA CTD PMID:23208426 NCBI chr 7:114,672,277...114,691,296 JBrowse link
G Cald1 caldesmon 1 increases expression EXP ferric nitrilotriacetate results in increased expression of CALD1 mRNA CTD PMID:10854235 NCBI chr 4:64,232,906...64,414,085 JBrowse link
G Canx calnexin increases expression EXP ferric nitrilotriacetate results in increased expression of CANX protein CTD PMID:16908007 NCBI chr10:35,124,941...35,157,954 JBrowse link
G Casp12 caspase 12 increases expression EXP ferric nitrilotriacetate results in increased expression of CASP12 mRNA CTD PMID:23208426 NCBI chr 8:10,927,188...10,954,442 JBrowse link
G Casp3 caspase 3 multiple interactions EXP [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP3 protein; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP3 mRNA; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP3 protein]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP3 mRNA] CTD PMID:21907755 NCBI chr16:52,395,539...52,413,794 JBrowse link
G Casp8 caspase 8 multiple interactions EXP [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP8 protein; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP8 mRNA; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP8 protein]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP8 mRNA] CTD PMID:21907755 NCBI chr 9:67,747,109...67,806,699 JBrowse link
G Casp9 caspase 9 multiple interactions EXP [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP9 protein; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP9 mRNA; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased cleavage of and results in decreased expression of CASP9 protein]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in decreased expression of CASP9 mRNA] CTD PMID:21907755
G Cat catalase multiple interactions
decreases activity		 EXP [Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of CAT protein; chrysin inhibits the reaction [ferric nitrilotriacetate results in decreased activity of CAT protein]; geraniol inhibits the reaction [ferric nitrilotriacetate results in decreased activity of CAT protein]; Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of CAT protein]; Quercetin inhibits the reaction [ferric nitrilotriacetate results in decreased activity of CAT protein] CTD PMID:9667754 PMID:15198074 PMID:18684806 PMID:21907755 PMID:23194824 More... NCBI chr 3:110,297,340...110,329,526 JBrowse link
G Ccnd1 cyclin D1 increases expression EXP ferric nitrilotriacetate results in increased expression of CCND1 mRNA; ferric nitrilotriacetate results in increased expression of CCND1 protein CTD PMID:18055543 NCBI chr 1:209,518,288...209,527,986 JBrowse link
G Cd44 CD44 molecule increases expression EXP ferric nitrilotriacetate results in increased expression of CD44 mRNA; ferric nitrilotriacetate results in increased expression of CD44 protein CTD PMID:18055543 NCBI chr 3:109,610,824...109,699,776 JBrowse link
G Cd47 Cd47 molecule increases expression EXP ferric nitrilotriacetate results in increased expression of CD47 mRNA CTD PMID:9119739 NCBI chr11:64,374,816...64,438,763 JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression EXP ferric nitrilotriacetate results in increased expression of CDKN1A mRNA CTD PMID:23208426 NCBI chr20:7,150,820...7,161,373 JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 decreases expression EXP ferric nitrilotriacetate results in decreased expression of CHRM1 mRNA CTD PMID:19490752 NCBI chr 1:205,567,226...205,583,001 JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 decreases expression EXP ferric nitrilotriacetate results in decreased expression of CHRM2 mRNA CTD PMID:19490752 NCBI chr 4:65,981,136...66,116,128 JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression
multiple interactions		 EXP ferric nitrilotriacetate results in increased expression of COL1A1 protein
ethylisopropylamiloride inhibits the reaction [ferric nitrilotriacetate results in increased expression of COL1A1 protein]		 CTD PMID:11159895 NCBI chr10:80,380,458...80,397,461 JBrowse link
G Cygb cytoglobin multiple interactions EXP CYGB protein inhibits the reaction [[ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TGFB1 mRNA]; CYGB protein inhibits the reaction [[ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TIMP1 mRNA]; CYGB protein results in decreased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid] CTD PMID:16581302 NCBI chr10:101,877,675...101,887,442 JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions ISO [[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT18 protein; [[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT8 protein; [Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein; allyl sulfide inhibits the reaction [CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]]; CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]; Ditiocarb inhibits the reaction [CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]]; Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin inhibits the reaction [CYP2E1 protein results in increased susceptibility to [ferric nitrilotriacetate co-treated with Arachidonic Acid]] CTD PMID:12086689 PMID:17034788 PMID:21352821 NCBI chr 1:205,269,967...205,280,365 JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO ferric nitrilotriacetate results in increased expression of FOS mRNA CTD PMID:10381381 NCBI chr 6:110,852,188...110,855,054 JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression EXP ferric nitrilotriacetate results in increased expression of FOSL1 mRNA; ferric nitrilotriacetate results in increased expression of FOSL1 protein CTD PMID:18055543 NCBI chr 1:212,183,885...212,192,391 JBrowse link
G G6pd glucose-6-phosphate dehydrogenase decreases activity EXP ferric nitrilotriacetate results in decreased activity of G6PD protein CTD PMID:9667754 NCBI chr  X:157,352,364...157,372,144 JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO ferric nitrilotriacetate results in increased expression of GCLC mRNA CTD PMID:18617210 NCBI chr 8:87,510,251...87,548,896 JBrowse link
G Gsr glutathione-disulfide reductase decreases activity
multiple interactions		 EXP ferric nitrilotriacetate results in decreased activity of GSR protein
[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of GSR protein; Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in decreased activity of GSR protein]; Quercetin inhibits the reaction [ferric nitrilotriacetate results in decreased activity of GSR protein]		 CTD PMID:9667754 PMID:15198074 PMID:30098279 NCBI chr16:65,185,574...65,228,742 JBrowse link
G Gtse1 G-2 and S-phase expressed 1 increases expression EXP ferric nitrilotriacetate results in increased expression of GTSE1 mRNA CTD PMID:23208426 NCBI chr 7:118,829,793...118,846,662 JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP [Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased secretion of HAVCR1 protein; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of HAVCR1 mRNA; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of HAVCR1 protein; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of HAVCR1 mRNA]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of HAVCR1 protein]; Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased secretion of HAVCR1 protein] CTD PMID:21907755 PMID:30098279 NCBI chr10:31,118,667...31,151,730 JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO ferric nitrilotriacetate inhibits the reaction [Asbestos, Crocidolite results in increased activity of HIF1A protein]; ferric nitrilotriacetate inhibits the reaction [Razoxane results in increased activity of HIF1A protein] CTD PMID:18385176 NCBI chr 6:98,357,788...98,405,068 JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP
ISO		 ferric nitrilotriacetate results in increased expression of HMOX1 mRNA CTD PMID:18617210 PMID:19490752 NCBI chr19:13,452,365...13,479,823 JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 increases expression EXP ferric nitrilotriacetate results in increased expression of HSP90AA1 mRNA CTD PMID:10854235 NCBI chr 6:135,523,604...135,529,687 JBrowse link
G Il24 interleukin 24 increases expression EXP ferric nitrilotriacetate results in increased expression of IL24 mRNA CTD PMID:23208426 NCBI chr13:44,905,362...44,910,760 JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions		 ISO
EXP		 ferric nitrilotriacetate results in increased expression of IL6 protein
ferric nitrilotriacetate results in increased expression of IL6 mRNA
[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of IL6 protein; chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of IL6 protein]		 CTD PMID:15781289 PMID:19490752 PMID:23194824 NCBI chr 4:5,889,999...5,894,575 JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases expression EXP ferric nitrilotriacetate results in increased expression of JUN mRNA; ferric nitrilotriacetate results in increased expression of JUN protein CTD PMID:18055543 NCBI chr 5:115,009,900...115,012,993 JBrowse link
G Krt18 keratin 18 multiple interactions ISO [[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT18 protein CTD PMID:17034788 NCBI chr 7:135,036,168...135,039,844 JBrowse link
G Krt8 keratin 8 multiple interactions ISO [[Arachidonic Acid co-treated with ferric nitrilotriacetate co-treated with Ethanol] results in increased expression of CYP2E1 protein] which results in increased expression of KRT8 protein CTD PMID:17034788 NCBI chr 7:135,002,886...135,010,339 JBrowse link
G Mcm3 minichromosome maintenance complex component 3 increases expression EXP ferric nitrilotriacetate results in increased expression of MCM3 mRNA CTD PMID:23208426 NCBI chr 9:30,715,602...30,733,746 JBrowse link
G Mt1 metallothionein 1 multiple interactions ISO [ferric nitrilotriacetate co-treated with Hydrogen Peroxide] inhibits the reaction [MT1 protein binds to Cadmium]; [ferric nitrilotriacetate co-treated with Hydrogen Peroxide] inhibits the reaction [MT1 protein binds to Zinc]; ferric nitrilotriacetate results in increased oxidation of [MT1 protein binds to Zinc] CTD PMID:22001350 NCBI chr19:10,831,959...10,832,975 JBrowse link
G Mt2A metallothionein 2A multiple interactions ISO [ferric nitrilotriacetate co-treated with Hydrogen Peroxide] inhibits the reaction [MT2 protein binds to Cadmium] CTD PMID:22001350 NCBI chr19:10,837,934...10,838,708 JBrowse link
G Mt3 metallothionein 3 decreases response to substance ISO MT3 protein results in decreased susceptibility to ferric nitrilotriacetate CTD PMID:12383939 NCBI chr19:10,848,754...10,850,158 JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression EXP ferric nitrilotriacetate results in increased expression of MYC mRNA; ferric nitrilotriacetate results in increased expression of MYC protein CTD PMID:18055543 NCBI chr 7:95,483,105...95,488,031 JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 affects localization ISO ferric nitrilotriacetate affects the localization of NFE2L2 protein CTD PMID:18617210 NCBI chr 3:81,001,529...81,031,165 JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of NFKB1 mRNA; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of NFKB1 mRNA] CTD PMID:21907755 NCBI chr 2:226,689,745...226,805,897 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression		 ISO
EXP		 ferric nitrilotriacetate inhibits the reaction [Doxorubicin results in increased expression of NOS2 mRNA]; ferric nitrilotriacetate inhibits the reaction [Doxorubicin results in increased expression of NOS2 protein]; ferric nitrilotriacetate inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
ferric nitrilotriacetate results in increased expression of NOS2 protein
[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of NOS2 protein; chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of NOS2 protein]; chrysin inhibits the reaction [ferric nitrilotriacetate results in increased expression of NOS2 protein]; ferric nitrilotriacetate promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 mRNA]; ferric nitrilotriacetate promotes the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]		 CTD PMID:11461780 PMID:11746204 PMID:12490132 PMID:23194824 NCBI chr10:64,313,335...64,349,221 JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression ISO ferric nitrilotriacetate results in increased expression of NQO1 mRNA; ferric nitrilotriacetate results in increased expression of NQO1 protein CTD PMID:18617210 NCBI chr19:52,205,374...52,220,267 JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions
increases activity		 EXP [ferric nitrilotriacetate results in increased abundance of Hydroxyl Radical] which results in increased activity of ODC1 protein; Active Hexose Correlated Compound inhibits the reaction [[ferric nitrilotriacetate results in increased abundance of Hydroxyl Radical] which results in increased activity of ODC1 protein]; Vitamin E inhibits the reaction [ferric nitrilotriacetate results in increased activity of ODC1 protein] CTD PMID:9667754 PMID:14623030 PMID:15949125 NCBI chr 6:46,058,439...46,065,148 JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 increases expression EXP ferric nitrilotriacetate results in increased expression of PCK1 mRNA CTD PMID:16960379 NCBI chr 3:182,348,572...182,354,521 JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP [Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PCNA protein; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of PCNA mRNA; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of PCNA protein; chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PCNA protein]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of PCNA mRNA]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of PCNA protein] CTD PMID:21907755 PMID:23194824 NCBI chr 3:139,951,948...139,955,820 JBrowse link
G Phlda3 pleckstrin homology-like domain, family A, member 3 increases expression EXP ferric nitrilotriacetate results in increased expression of PHLDA3 mRNA CTD PMID:23208426 NCBI chr13:47,193,250...47,196,335 JBrowse link
G Plau plasminogen activator, urokinase multiple interactions
increases expression
increases activity		 ISO Deferoxamine inhibits the reaction [ferric nitrilotriacetate results in increased activity of PLAU mRNA]; Deferoxamine inhibits the reaction [ferric nitrilotriacetate results in increased expression of PLAU mRNA] CTD PMID:17571974 NCBI chr15:3,505,485...3,511,987 JBrowse link
G Plk2 polo-like kinase 2 increases expression EXP ferric nitrilotriacetate results in increased expression of PLK2 mRNA CTD PMID:23208426 NCBI chr 2:43,702,536...43,708,305 JBrowse link
G Pola1 DNA polymerase alpha 1, catalytic subunit increases expression EXP ferric nitrilotriacetate results in increased expression of POLA1 mRNA CTD PMID:10854235 NCBI chr  X:62,028,475...62,342,455 JBrowse link
G Ppia peptidylprolyl isomerase A increases expression EXP ferric nitrilotriacetate results in increased expression of PPIA protein CTD PMID:16908007 NCBI chr14:81,279,292...81,282,960 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression		 EXP [Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PTGS2 protein; chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PTGS2 protein]; chrysin inhibits the reaction [ferric nitrilotriacetate results in increased expression of PTGS2 protein]; Hesperidin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of PTGS2 protein] CTD PMID:23194824 PMID:30098279 NCBI chr13:64,714,063...64,722,320 JBrowse link
G Ptprb protein tyrosine phosphatase, receptor type, B decreases expression EXP ferric nitrilotriacetate results in decreased expression of PTPRB mRNA CTD PMID:10854235 NCBI chr 7:51,953,375...52,034,751 JBrowse link
G Ptprz1 protein tyrosine phosphatase, receptor type Z1 increases expression EXP ferric nitrilotriacetate results in increased expression of PTPRZ1 mRNA; ferric nitrilotriacetate results in increased expression of PTPRZ1 protein CTD PMID:18055543 NCBI chr 4:51,397,316...51,595,220 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP [Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased localization of RELA protein; chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased localization of RELA protein] CTD PMID:23194824 NCBI chr 1:212,354,336...212,364,815 JBrowse link
G Rpl19 ribosomal protein L19 increases expression EXP ferric nitrilotriacetate results in increased expression of RPL19 mRNA CTD PMID:10854235 NCBI chr10:83,022,503...83,026,030 JBrowse link
G Rprm reprimo, TP53 dependent G2 arrest mediator homolog increases expression EXP ferric nitrilotriacetate results in increased expression of RPRM mRNA CTD PMID:23208426 NCBI chr 3:58,948,618...58,950,035 JBrowse link
G Rps13 ribosomal protein S13 increases expression EXP ferric nitrilotriacetate results in increased expression of RPS13 mRNA CTD PMID:10854235 NCBI chr 1:170,572,925...170,575,355 JBrowse link
G Rps15 ribosomal protein S15 increases expression EXP ferric nitrilotriacetate results in increased expression of RPS15 mRNA CTD PMID:10854235 NCBI chr 7:9,416,003...9,417,442 JBrowse link
G Slc11a2 solute carrier family 11 member 2 decreases expression ISO ferric nitrilotriacetate results in decreased expression of SLC11A2 mRNA CTD PMID:11925462 NCBI chr 7:131,503,076...131,540,246 JBrowse link
G Slc40a1 solute carrier family 40 member 1 decreases expression ISO ferric nitrilotriacetate results in decreased expression of SLC40A1 mRNA CTD PMID:11925462 NCBI chr 9:55,525,457...55,633,463 JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP ferric nitrilotriacetate inhibits the reaction [Dimethylnitrosamine results in decreased expression of SOD1 protein] CTD PMID:15842777 NCBI chr11:42,942,742...42,948,399 JBrowse link
G Ssrp1 structure specific recognition protein 1 increases expression EXP ferric nitrilotriacetate results in increased expression of SSRP1 mRNA CTD PMID:8844983 NCBI chr 3:70,124,371...70,134,481 JBrowse link
G Tgfa transforming growth factor alpha increases expression EXP ferric nitrilotriacetate results in increased expression of TGFA mRNA; ferric nitrilotriacetate results in increased expression of TGFA protein CTD PMID:8340253 NCBI chr 4:120,175,549...120,258,342 JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP [ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TGFB1 mRNA; CYGB protein inhibits the reaction [[ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TGFB1 mRNA] CTD PMID:16581302 NCBI chr 1:90,324,312...90,340,627 JBrowse link
G Tgfb2 transforming growth factor, beta 2 increases expression EXP ferric nitrilotriacetate results in increased expression of TGFB2 mRNA CTD PMID:23208426 NCBI chr13:98,160,075...98,261,771 JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP [ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TIMP1 mRNA; CYGB protein inhibits the reaction [[ferric nitrilotriacetate co-treated with Arachidonic Acid] results in increased expression of TIMP1 mRNA] CTD PMID:16581302 NCBI chr  X:3,766,509...3,772,578 JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 ISO
EXP		 ferric nitrilotriacetate results in increased expression of TNF protein
[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of TNF protein; chrysin inhibits the reaction [[Diethylnitrosamine co-treated with ferric nitrilotriacetate] results in increased expression of TNF protein]		 CTD PMID:15781289 PMID:23194824 NCBI chr20:3,626,685...3,629,303 JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of TP53 mRNA; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of TP53 protein; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of TP53 mRNA]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of TP53 protein] CTD PMID:21907755 NCBI chr10:54,798,871...54,810,300 JBrowse link
G Txn1 thioredoxin 1 increases expression EXP ferric nitrilotriacetate results in increased expression of TXN protein CTD PMID:15834431 NCBI chr 5:77,507,455...77,519,685 JBrowse link
G Txnip thioredoxin interacting protein decreases expression
increases methylation		 EXP ferric nitrilotriacetate results in decreased expression of TXNIP protein
ferric nitrilotriacetate results in increased methylation of TXNIP promoter		 CTD PMID:15834431 NCBI chr 2:186,781,933...186,785,736 JBrowse link
G Ubd ubiquitin D increases expression EXP ferric nitrilotriacetate results in increased expression of UBD mRNA CTD PMID:23208426 NCBI chr20:1,385,487...1,387,438 JBrowse link
lumefantrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fshb follicle stimulating hormone subunit beta decreases secretion EXP Lumefantrine results in decreased secretion of FSHB protein CTD PMID:26811345 NCBI chr 3:114,003,262...114,007,072 JBrowse link
G Prl prolactin increases secretion EXP Lumefantrine results in increased secretion of PRL protein CTD PMID:26811345 NCBI chr17:38,287,355...38,298,234 JBrowse link
N(6),N(6)-dimethyladenine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin multiple interactions EXP N(6),N(6)-dimethyladenine inhibits the reaction [Cadmium Chloride results in increased expression of A2M protein] CTD PMID:15618353 NCBI chr 4:154,897,770...154,947,787 JBrowse link
G Cdh1 cadherin 1 multiple interactions EXP N(6),N(6)-dimethyladenine promotes the reaction [Cadmium Chloride results in decreased expression of CDH1 protein] CTD PMID:15618353 NCBI chr19:51,402,178...51,471,572 JBrowse link
G Cdh2 cadherin 2 multiple interactions EXP N(6),N(6)-dimethyladenine promotes the reaction [Cadmium Chloride results in decreased expression of CDH2 protein] CTD PMID:15618353 NCBI chr18:8,051,097...8,265,288 JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP N(6),N(6)-dimethyladenine promotes the reaction [Cadmium Chloride results in decreased expression of CTNNB1 protein] CTD PMID:15618353 NCBI chr 8:129,517,576...129,544,661 JBrowse link
G Lig1 DNA ligase 1 multiple interactions ISO N(6),N(6)-dimethyladenine inhibits the reaction [2-chloroethyl ethyl sulfide results in increased phosphorylation of LIG1 protein] CTD PMID:16700562 NCBI chr 1:83,243,043...83,281,707 JBrowse link
G