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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:homoserine lactone
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Accession:CHEBI:17289 term browser browse the term
Definition:A butan-4-olide having an amino substituent at the 2-position.
Synonyms:exact_synonym: 3-amino-4,5-dihydrofuran-2(3H)-one
 related_synonym: 2-Aminobutan-4-olide;   Formula=C4H7NO2;   HSL;   HSLs;   InChI=1S/C4H7NO2/c5-3-1-2-7-4(3)6/h3H,1-2,5H2;   InChIKey=QJPWUUJVYOJNMH-UHFFFAOYSA-N;   SMILES=NC1CCOC1=O;   alpha-amino-gamma-butyrolactone
 alt_id: CHEBI:1017;   CHEBI:11522;   CHEBI:19468;   CHEBI:30656
 xref: Beilstein:80584;   CAS:1192-20-7;   DrugBank:DB02624;   KEGG:C02926;   MetaCyc:HOMOSERINE-LACTONE;   PMID:7545940;   Reaxys:80584
 cyclic_relationship: is_conjugate_base_of CHEBI:58093


show annotations for term's descendants           Sort by:
N-(3-oxododecanoyl)homoserine lactone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO N-(3-oxododecanoyl)homoserine lactone results in increased activity of CASP3 protein CTD PMID:25627690 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 increases activity ISO N-(3-oxododecanoyl)homoserine lactone results in increased activity of CASP7 protein CTD PMID:25627690 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G P2ry2 purinergic receptor P2Y2 multiple interactions
decreases expression		 ISO Ibuprofen inhibits the reaction [N-(3-oxododecanoyl)homoserine lactone results in decreased expression of P2RY2 mRNA] CTD PMID:10496880 NCBI chr 1:155,352,050...155,367,423
Ensembl chr 1:155,351,165...155,367,632 		JBrowse link
G P2ry4 pyrimidinergic receptor P2Y4 decreases expression ISO N-(3-oxododecanoyl)homoserine lactone results in decreased expression of P2RY4 mRNA CTD PMID:10496880 NCBI chr  X:65,681,680...65,717,404
Ensembl chr  X:65,683,232...65,721,748 		JBrowse link
G Pon2 paraoxonase 2 increases response to substance ISO PON2 protein results in increased susceptibility to N-(3-oxododecanoyl)homoserine lactone CTD PMID:25627690 NCBI chr 4:33,389,702...33,425,186
Ensembl chr 4:33,389,714...33,425,248 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      application 19627
        NMR chemical shift reference compound 17938
          ammonia 17797
            organic amino compound 17797
              primary amino compound 9301
                homoserine lactone 5
                  D-homoserine lactone 0
                  L-homoserine lactone + 0
                  N-acyl homoserine lactone + 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            heteroorganic entity 19460
                              organochalcogen compound 19224
                                organooxygen compound 19141
                                  ester 17332
                                    carboxylic ester 16714
                                      lactone 13224
                                        gamma-lactone 6851
                                          butan-4-olide 308
                                            homoserine lactone 5
                                              D-homoserine lactone 0
                                              L-homoserine lactone + 0
                                              N-acyl homoserine lactone + 5
paths to the root