P2ry4 (pyrimidinergic receptor P2Y4) - Rat Genome Database

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Gene: P2ry4 (pyrimidinergic receptor P2Y4) Rattus norvegicus
Analyze
Symbol: P2ry4
Name: pyrimidinergic receptor P2Y4
RGD ID: 61798
Description: Enables ATP binding activity. Involved in regulation of presynaptic cytosolic calcium ion concentration and regulation of synaptic vesicle exocytosis. Located in apical plasma membrane and basolateral plasma membrane. Is active in glutamatergic synapse and presynaptic active zone membrane. Orthologous to human P2RY4 (pyrimidinergic receptor P2Y4); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: P2Y ATP receptor 4; P2Y purinoceptor 4; P2Y4; purinergic receptor P2Y G-protein coupled 4; purinergic receptor P2Y, G-protein coupled 4; pyrimidinergic receptor P2Y G-protein coupled 4; pyrimidinergic receptor P2Y, G-protein coupled, 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X69,722,604 - 69,757,726 (-)NCBIGRCr8
mRatBN7.2X65,681,680 - 65,717,404 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX65,683,232 - 65,721,748 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX67,170,441 - 67,171,854 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X70,670,833 - 70,672,246 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X68,231,732 - 68,233,145 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X70,421,599 - 70,447,109 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX70,426,951 - 70,428,364 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X71,296,545 - 71,329,324 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X88,589,534 - 88,590,947 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X88,662,966 - 88,664,380 (-)NCBI
CeleraX66,045,899 - 66,047,312 (-)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Molecular cloning and characterization of rat P2Y4 nucleotide receptor. Bogdanov YD, etal., Br J Pharmacol 1998 Jun;124(3):428-30.
2. Polarized expression and function of P2Y ATP receptors in rat bile duct epithelia. Dranoff JA, etal., Am J Physiol Gastrointest Liver Physiol 2001 Oct;281(4):G1059-67.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Dual presynaptic control by ATP of glutamate release via facilitatory P2X1, P2X2/3, and P2X3 and inhibitory P2Y1, P2Y2, and/or P2Y4 receptors in the rat hippocampus. Rodrigues RJ, etal., J Neurosci. 2005 Jul 6;25(27):6286-95.
10. Molecular cloning and characterization of the mouse P2Y4 nucleotide receptor. Suarez-Huerta N, etal., Eur J Pharmacol 2001 Mar 30;416(3):197-202.
11. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:9751165   PMID:11259526   PMID:12850289   PMID:14564529   PMID:14764443   PMID:16075244   PMID:17433586   PMID:18216148   PMID:18625291   PMID:19191015   PMID:19244398   PMID:21300137  
PMID:23479225   PMID:24771361   PMID:28468962   PMID:33122160   PMID:36591760  


Genomics

Comparative Map Data
P2ry4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X69,722,604 - 69,757,726 (-)NCBIGRCr8
mRatBN7.2X65,681,680 - 65,717,404 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX65,683,232 - 65,721,748 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX67,170,441 - 67,171,854 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X70,670,833 - 70,672,246 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X68,231,732 - 68,233,145 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X70,421,599 - 70,447,109 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX70,426,951 - 70,428,364 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X71,296,545 - 71,329,324 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X88,589,534 - 88,590,947 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X88,662,966 - 88,664,380 (-)NCBI
CeleraX66,045,899 - 66,047,312 (-)NCBICelera
Cytogenetic MapXq22NCBI
P2RY4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X70,258,166 - 70,260,204 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX70,258,166 - 70,260,204 (-)EnsemblGRCh38hg38GRCh38
GRCh37X69,478,016 - 69,480,054 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X69,394,741 - 69,396,379 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X69,261,247 - 69,262,675NCBI
CeleraX69,831,353 - 69,832,991 (-)NCBICelera
Cytogenetic MapXq13.1NCBI
HuRefX63,299,114 - 63,300,752 (-)NCBIHuRef
CHM1_1X69,371,994 - 69,373,632 (-)NCBICHM1_1
T2T-CHM13v2.0X68,691,490 - 68,693,528 (-)NCBIT2T-CHM13v2.0
P2ry4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X99,631,964 - 99,638,533 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX99,633,760 - 99,638,475 (-)EnsemblGRCm39 Ensembl
GRCm38X100,588,358 - 100,594,927 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX100,590,154 - 100,594,869 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X97,785,493 - 97,790,208 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X96,792,873 - 96,797,588 (-)NCBIMGSCv36mm8
CeleraX87,516,188 - 87,520,903 (-)NCBICelera
Cytogenetic MapXC3NCBI
cM MapX43.72NCBI
P2ry4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554759,800,541 - 9,802,055 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554759,794,538 - 9,802,055 (-)NCBIChiLan1.0ChiLan1.0
P2RY4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X69,935,449 - 69,937,488 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X69,939,051 - 69,941,090 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X59,526,621 - 59,528,248 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X69,585,984 - 69,587,611 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX69,586,340 - 69,587,437 (-)Ensemblpanpan1.1panPan2
P2RY4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X54,706,404 - 54,707,512 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX45,532,412 - 45,533,520 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X55,672,553 - 55,673,661 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X53,641,532 - 53,642,640 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X54,972,339 - 54,973,447 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X54,899,511 - 54,900,619 (-)NCBIUU_Cfam_GSD_1.0
P2ry4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X47,455,684 - 47,457,937 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367621,217,858 - 1,218,950 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367621,217,858 - 1,218,948 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
P2RY4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX56,279,346 - 56,286,400 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X56,284,736 - 56,285,833 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X63,479,522 - 63,480,619 (-)NCBISscrofa10.2Sscrofa10.2susScr3
P2RY4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X60,099,961 - 60,104,094 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX60,102,265 - 60,103,362 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660651,948,078 - 1,950,108 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
P2ry4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624903223,520 - 259,111 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624903221,985 - 257,903 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in P2ry4
115 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:75
Count of miRNA genes:66
Interacting mature miRNAs:71
Transcripts:ENSRNOT00000045907
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 48 113 91 90 59 25 59 6 216 96 93 44 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063280273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063280274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063280275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063280276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC141377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y11433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y14705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000045907   ⟹   ENSRNOP00000039027
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX65,686,252 - 65,721,748 (-)Ensembl
Rnor_6.0 EnsemblX70,426,951 - 70,428,364 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096316   ⟹   ENSRNOP00000094459
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX65,683,232 - 65,721,748 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099755   ⟹   ENSRNOP00000085052
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX65,686,252 - 65,721,604 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112073   ⟹   ENSRNOP00000082634
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX65,683,232 - 65,721,748 (-)Ensembl
RefSeq Acc Id: NM_031680   ⟹   NP_113868
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X69,727,113 - 69,728,526 (-)NCBI
mRatBN7.2X65,687,032 - 65,688,445 (-)NCBI
Rnor_6.0X70,426,951 - 70,428,364 (-)NCBI
Rnor_5.0X71,296,545 - 71,329,324 (-)NCBI
RGSC_v3.4X88,589,534 - 88,590,947 (-)RGD
CeleraX66,045,899 - 66,047,312 (-)RGD
Sequence:
RefSeq Acc Id: XM_039100005   ⟹   XP_038955933
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X69,722,604 - 69,745,513 (-)NCBI
mRatBN7.2X65,681,680 - 65,705,437 (-)NCBI
RefSeq Acc Id: XM_039100006   ⟹   XP_038955934
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X69,722,604 - 69,752,295 (-)NCBI
mRatBN7.2X65,681,680 - 65,707,199 (-)NCBI
RefSeq Acc Id: XM_039100007   ⟹   XP_038955935
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X69,722,604 - 69,754,368 (-)NCBI
mRatBN7.2X65,681,680 - 65,717,382 (-)NCBI
RefSeq Acc Id: XM_039100009   ⟹   XP_038955937
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X69,722,604 - 69,757,726 (-)NCBI
mRatBN7.2X65,681,680 - 65,717,382 (-)NCBI
RefSeq Acc Id: XM_039100011   ⟹   XP_038955939
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X69,722,604 - 69,754,368 (-)NCBI
mRatBN7.2X65,681,680 - 65,717,382 (-)NCBI
RefSeq Acc Id: XM_039100012   ⟹   XP_038955940
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X69,722,604 - 69,757,726 (-)NCBI
mRatBN7.2X65,681,680 - 65,717,382 (-)NCBI
RefSeq Acc Id: XM_039100014   ⟹   XP_038955942
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X69,722,604 - 69,754,368 (-)NCBI
mRatBN7.2X65,681,680 - 65,717,382 (-)NCBI
RefSeq Acc Id: XM_039100015   ⟹   XP_038955943
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X69,722,604 - 69,757,726 (-)NCBI
mRatBN7.2X65,681,680 - 65,717,404 (-)NCBI
RefSeq Acc Id: XM_063280273   ⟹   XP_063136343
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X69,722,604 - 69,752,295 (-)NCBI
RefSeq Acc Id: XM_063280274   ⟹   XP_063136344
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X69,722,604 - 69,754,368 (-)NCBI
RefSeq Acc Id: XM_063280275   ⟹   XP_063136345
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X69,722,604 - 69,757,726 (-)NCBI
RefSeq Acc Id: XM_063280276   ⟹   XP_063136346
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X69,722,604 - 69,752,295 (-)NCBI
RefSeq Acc Id: NP_113868   ⟸   NM_031680
- UniProtKB: O35811 (UniProtKB/Swiss-Prot),   A6IQ78 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000039027   ⟸   ENSRNOT00000045907
RefSeq Acc Id: XP_038955943   ⟸   XM_039100015
- Peptide Label: isoform X1
- UniProtKB: O35811 (UniProtKB/Swiss-Prot),   A6IQ78 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955940   ⟸   XM_039100012
- Peptide Label: isoform X1
- UniProtKB: O35811 (UniProtKB/Swiss-Prot),   A6IQ78 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955937   ⟸   XM_039100009
- Peptide Label: isoform X1
- UniProtKB: O35811 (UniProtKB/Swiss-Prot),   A6IQ78 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955942   ⟸   XM_039100014
- Peptide Label: isoform X1
- UniProtKB: O35811 (UniProtKB/Swiss-Prot),   A6IQ78 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955939   ⟸   XM_039100011
- Peptide Label: isoform X1
- UniProtKB: O35811 (UniProtKB/Swiss-Prot),   A6IQ78 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955935   ⟸   XM_039100007
- Peptide Label: isoform X1
- UniProtKB: O35811 (UniProtKB/Swiss-Prot),   A6IQ78 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955934   ⟸   XM_039100006
- Peptide Label: isoform X1
- UniProtKB: O35811 (UniProtKB/Swiss-Prot),   A6IQ78 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955933   ⟸   XM_039100005
- Peptide Label: isoform X1
- UniProtKB: O35811 (UniProtKB/Swiss-Prot),   A6IQ78 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000085052   ⟸   ENSRNOT00000099755
Ensembl Acc Id: ENSRNOP00000082634   ⟸   ENSRNOT00000112073
Ensembl Acc Id: ENSRNOP00000094459   ⟸   ENSRNOT00000096316
RefSeq Acc Id: XP_063136345   ⟸   XM_063280275
- Peptide Label: isoform X1
- UniProtKB: O35811 (UniProtKB/Swiss-Prot),   A6IQ78 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063136344   ⟸   XM_063280274
- Peptide Label: isoform X1
- UniProtKB: O35811 (UniProtKB/Swiss-Prot),   A6IQ78 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063136346   ⟸   XM_063280276
- Peptide Label: isoform X1
- UniProtKB: O35811 (UniProtKB/Swiss-Prot),   A6IQ78 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063136343   ⟸   XM_063280273
- Peptide Label: isoform X1
- UniProtKB: O35811 (UniProtKB/Swiss-Prot),   A6IQ78 (UniProtKB/TrEMBL)
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35811-F1-model_v2 AlphaFold O35811 1-361 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61798 AgrOrtholog
BioCyc Gene G2FUF-2130 BioCyc
Ensembl Genes ENSRNOG00000002953 Ensembl
  ENSRNOG00000070777 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055029214 UniProtKB/Swiss-Prot
  ENSRNOG00060023391 UniProtKB/Swiss-Prot
  ENSRNOG00065016678 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000045907.3 UniProtKB/Swiss-Prot
  ENSRNOT00000096316.1 UniProtKB/Swiss-Prot
  ENSRNOT00000099755.1 UniProtKB/Swiss-Prot
  ENSRNOT00000112073.1 UniProtKB/Swiss-Prot
  ENSRNOT00055050631 UniProtKB/Swiss-Prot
  ENSRNOT00055050633 UniProtKB/Swiss-Prot
  ENSRNOT00055050647 UniProtKB/Swiss-Prot
  ENSRNOT00055050655 UniProtKB/Swiss-Prot
  ENSRNOT00060040529 UniProtKB/Swiss-Prot
  ENSRNOT00060040568 UniProtKB/Swiss-Prot
  ENSRNOT00060040630 UniProtKB/Swiss-Prot
  ENSRNOT00060040655 UniProtKB/Swiss-Prot
  ENSRNOT00065027801 UniProtKB/Swiss-Prot
  ENSRNOT00065027805 UniProtKB/Swiss-Prot
  ENSRNOT00065027819 UniProtKB/Swiss-Prot
  ENSRNOT00065027823 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2Y4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:63843 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 63843 ENTREZGENE
PANTHER P2Y PURINOCEPTOR 4 UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen P2ry4 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2Y4PRNOCPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P2YPURNOCPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002953 RatGTEx
  ENSRNOG00000070777 RatGTEx
  ENSRNOG00055029214 RatGTEx
  ENSRNOG00060023391 RatGTEx
  ENSRNOG00065016678 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC202238
UniProt A6IQ78 ENTREZGENE, UniProtKB/TrEMBL
  O35811 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 P2ry4  pyrimidinergic receptor P2Y4  P2ry4  pyrimidinergic receptor P2Y, G-protein coupled, 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 P2ry4  pyrimidinergic receptor P2Y, G-protein coupled, 4    purinergic receptor P2Y, G-protein coupled 4  Name updated 1299863 APPROVED
2002-06-10 P2ry4  purinergic receptor P2Y, G-protein coupled 4      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the apical plasma membrane and basolateral domains 628452
gene_expression mRNA present in holangiocytes, hepatocytes and epithelial cells 628452
gene_process may mediate vasomotor responses, neurotransmission, platelet aggregation, and secretion 628452
gene_regulation receptor activity is suramin-insensitive 628452