P2ry4 (pyrimidinergic receptor P2Y4) - Rat Genome Database

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Gene: P2ry4 (pyrimidinergic receptor P2Y4) Rattus norvegicus
Analyze
Symbol: P2ry4
Name: pyrimidinergic receptor P2Y4
RGD ID: 61798
Description: Enables ATP binding activity. Involved in regulation of presynaptic cytosolic calcium ion concentration and regulation of synaptic vesicle exocytosis. Located in apical plasma membrane and basolateral plasma membrane. Is active in glutamatergic synapse and presynaptic active zone membrane. Orthologous to human P2RY4 (pyrimidinergic receptor P2Y4); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: P2Y ATP receptor 4; P2Y purinoceptor 4; P2Y4; purinergic receptor P2Y G-protein coupled 4; purinergic receptor P2Y, G-protein coupled 4; pyrimidinergic receptor P2Y G-protein coupled 4; pyrimidinergic receptor P2Y, G-protein coupled, 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X69,722,604 - 69,757,726 (-)NCBIGRCr8
mRatBN7.2X65,681,680 - 65,717,404 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX65,683,232 - 65,721,748 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX67,170,441 - 67,171,854 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X70,670,833 - 70,672,246 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X68,231,732 - 68,233,145 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X70,421,599 - 70,447,109 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX70,426,951 - 70,428,364 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X71,296,545 - 71,329,324 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X88,589,534 - 88,590,947 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X88,662,966 - 88,664,380 (-)NCBI
CeleraX66,045,899 - 66,047,312 (-)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
P2ry4Ratautistic disorder  ISOP2RY4 (Homo sapiens)8554872ClinVar Annotator: match by term: AutismClinVarPMID:21681106 and PMID:30208311
P2ry4Ratautosomal hemophilia A  ISOP2RY4 (Homo sapiens)8554872ClinVar Annotator: match by term: AUTOSOMAL HEMOPHILIA AClinVarPMID:31690835
P2ry4Ratepilepsy  ISOP2RY4 (Homo sapiens)8554872ClinVar Annotator: match by term: SeizureClinVar 
P2ry4Ratfactor VIII deficiency  ISOP2RY4 (Homo sapiens)8554872ClinVar Annotator: match by term: Factor 8 deficiency and congenitalClinVarPMID:31690835
P2ry4Ratsyndromic X-linked intellectual disability Lubs type  ISOP2RY4 (Homo sapiens)8554872ClinVar Annotator: match by term: Syndromic X-linked intellectual disability Lubs typeClinVarPMID:25741868

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Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
P2ry4Rat(1->4)-beta-D-glucan multiple interactionsISOP2ry4 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of P2RY4 mRNACTDPMID:36331819
P2ry4Rat17beta-estradiol decreases expressionISOP2ry4 (Mus musculus)6480464Estradiol results in decreased expression of P2RY4 mRNACTDPMID:39298647
P2ry4Rat2,2',4,4'-Tetrabromodiphenyl ether affects expressionISOP2ry4 (Mus musculus)64804642 more ...CTDPMID:30294300
P2ry4Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOP2ry4 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of P2RY4 mRNACTDPMID:26377647
P2ry4Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of P2RY4 mRNACTDPMID:33387578
P2ry4Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOP2ry4 (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of P2RY4 mRNACTDPMID:25975270 and PMID:26290441
P2ry4Rat2,6-dinitrotoluene affects expressionEXP 64804642 and 6-dinitrotoluene affects the expression of P2RY4 mRNACTDPMID:21346803
P2ry4Rat4,4'-sulfonyldiphenol decreases expressionISOP2ry4 (Mus musculus)6480464bisphenol S results in decreased expression of P2RY4 mRNACTDPMID:39298647
P2ry4Ratacetamide increases expressionEXP 6480464acetamide results in increased expression of P2RY4 mRNACTDPMID:31881176
P2ry4Ratacrylamide increases expressionEXP 6480464Acrylamide results in increased expression of P2RY4 mRNACTDPMID:28959563
P2ry4Ratammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of P2RY4 mRNACTDPMID:16483693
P2ry4RatATP multiple interactionsISOP2RY4 (Homo sapiens)6480464[Adenosine Triphosphate binds to and results in increased activity of P2RY4 protein] which results in increased abundance of Calcium more ...CTDPMID:12694404
P2ry4RatAzoxymethane multiple interactionsISOP2ry4 (Mus musculus)6480464[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of P2RY4 mRNACTDPMID:29950665
P2ry4Ratbenzo[a]pyrene decreases expressionISOP2RY4 (Homo sapiens)6480464Benzo(a)pyrene results in decreased expression of P2RY4 mRNACTDPMID:22316170
P2ry4Ratbenzo[a]pyrene affects methylationISOP2RY4 (Homo sapiens)6480464Benzo(a)pyrene affects the methylation of P2RY4 promoterCTDPMID:27901495
P2ry4Ratbenzo[a]pyrene decreases methylationISOP2RY4 (Homo sapiens)6480464Benzo(a)pyrene results in decreased methylation of P2RY4 exonCTDPMID:27901495
P2ry4Ratbisphenol A affects expressionEXP 6480464bisphenol A affects the expression of P2RY4 mRNACTDPMID:25181051
P2ry4Ratbisphenol A increases expressionEXP 6480464bisphenol A results in increased expression of P2RY4 mRNACTDPMID:30816183 more ...
P2ry4Ratbisphenol F increases expressionISOP2ry4 (Mus musculus)6480464bisphenol F results in increased expression of P2RY4 mRNACTDPMID:38685157
P2ry4Ratcalcium atom multiple interactionsISOP2RY4 (Homo sapiens)6480464[Adenosine Triphosphate binds to and results in increased activity of P2RY4 protein] which results in increased abundance of Calcium and Trichloroethylene inhibits the reaction [[Adenosine Triphosphate binds to and results in increased activity of P2RY4 protein] which results in increased abundance of Calcium]CTDPMID:12694404

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Biological Process
1 to 14 of 14 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
P2ry4Ratcellular response to prostaglandin E stimulus acts_upstream_of_or_withinISOP2ry4 (Mus musculus)1624291 PMID:23479225RGDPMID:23479225
P2ry4RatG protein-coupled purinergic nucleotide receptor signaling pathway involved_inIEAGO:00450281600115GO_REF:0000108GOCGO_REF:0000108
P2ry4RatG protein-coupled receptor signaling pathway involved_inIEAInterPro:IPR000018 and InterPro:IPR0002761600115GO_REF:0000002InterProGO_REF:0000002
P2ry4RatG protein-coupled receptor signaling pathway involved_inIBAMGI:1934135 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
P2ry4RatG protein-coupled receptor signaling pathway involved_inIEAUniProtKB-KW:KW-02971600115GO_REF:0000043UniProtGO_REF:0000043
P2ry4Ratregulation of presynaptic cytosolic calcium ion concentration involved_inEXP 1581702PMID:16000618SynGO 
P2ry4Ratregulation of presynaptic cytosolic calcium ion concentration involved_inIEP 1581702PMID:16000618SynGO 
P2ry4Ratregulation of presynaptic cytosolic calcium ion concentration involved_inIDA 1581702PMID:16000618SynGO 
P2ry4Ratregulation of synaptic vesicle exocytosis involved_inEXP 1581702PMID:16000618SynGO 
P2ry4Ratregulation of synaptic vesicle exocytosis involved_inIEP 1581702PMID:16000618SynGO 
P2ry4Ratregulation of synaptic vesicle exocytosis involved_inIDA 1581702PMID:16000618SynGO 
P2ry4Ratsignal transduction involved_inIEAUniProtKB-KW:KW-08071600115GO_REF:0000043UniProtGO_REF:0000043
P2ry4Rattransepithelial chloride transport involved_inIEAInterPro:IPR0000181600115GO_REF:0000002InterProGO_REF:0000002
P2ry4Rattransepithelial chloride transport acts_upstream_of_or_withinISOP2ry4 (Mus musculus)1624291 PMID:11259526RGDPMID:11259526
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Cellular Component
1 to 12 of 12 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
P2ry4Ratapical plasma membrane  IDA 628452 RGD 
P2ry4Ratbasolateral plasma membrane  IDA 628452 RGD 
P2ry4Ratglutamatergic synapse is_active_inEXP 1581702PMID:16000618SynGO 
P2ry4Ratglutamatergic synapse is_active_inIEP 1581702PMID:16000618SynGO 
P2ry4Ratglutamatergic synapse is_active_inIDA 1581702PMID:16000618SynGO 
P2ry4Ratmembrane located_inIEAInterPro:IPR000018 more ...1600115GO_REF:0000002InterProGO_REF:0000002
P2ry4Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
P2ry4Ratplasma membrane located_inIEAUniProtKB-KW:KW-10031600115GO_REF:0000043UniProtGO_REF:0000043
P2ry4Ratplasma membrane located_inIEAUniProtKB-SubCell:SL-00391600115GO_REF:0000044UniProtGO_REF:0000044
P2ry4Ratplasma membrane is_active_inIBAMGI:105049 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
P2ry4Ratpresynaptic active zone membrane is_active_inIDA 1581702PMID:16000618SynGO 
P2ry4Ratpresynaptic active zone membrane is_active_inIEP 1581702PMID:16000618SynGO 
1 to 12 of 12 rows

Molecular Function

  


1 to 11 of 11 rows
#
Reference Title
Reference Citation
1. Molecular cloning and characterization of rat P2Y4 nucleotide receptor. Bogdanov YD, etal., Br J Pharmacol 1998 Jun;124(3):428-30.
2. Polarized expression and function of P2Y ATP receptors in rat bile duct epithelia. Dranoff JA, etal., Am J Physiol Gastrointest Liver Physiol 2001 Oct;281(4):G1059-67.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Dual presynaptic control by ATP of glutamate release via facilitatory P2X1, P2X2/3, and P2X3 and inhibitory P2Y1, P2Y2, and/or P2Y4 receptors in the rat hippocampus. Rodrigues RJ, etal., J Neurosci. 2005 Jul 6;25(27):6286-95.
10. Molecular cloning and characterization of the mouse P2Y4 nucleotide receptor. Suarez-Huerta N, etal., Eur J Pharmacol 2001 Mar 30;416(3):197-202.
11. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
1 to 11 of 11 rows
PMID:9751165   PMID:11259526   PMID:12850289   PMID:14564529   PMID:14764443   PMID:16075244   PMID:17433586   PMID:18216148   PMID:18625291   PMID:19191015   PMID:19244398   PMID:21300137  
PMID:23479225   PMID:24771361   PMID:28468962   PMID:33122160   PMID:36591760  



P2ry4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X69,722,604 - 69,757,726 (-)NCBIGRCr8
mRatBN7.2X65,681,680 - 65,717,404 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX65,683,232 - 65,721,748 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX67,170,441 - 67,171,854 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X70,670,833 - 70,672,246 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X68,231,732 - 68,233,145 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X70,421,599 - 70,447,109 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX70,426,951 - 70,428,364 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X71,296,545 - 71,329,324 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X88,589,534 - 88,590,947 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X88,662,966 - 88,664,380 (-)NCBI
CeleraX66,045,899 - 66,047,312 (-)NCBICelera
Cytogenetic MapXq22NCBI
P2RY4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X70,258,166 - 70,260,204 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX70,258,166 - 70,260,204 (-)EnsemblGRCh38hg38GRCh38
GRCh37X69,478,016 - 69,480,054 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X69,394,741 - 69,396,379 (-)NCBINCBI36Build 36hg18NCBI36
Build 34X69,261,247 - 69,262,675NCBI
CeleraX69,831,353 - 69,832,991 (-)NCBICelera
Cytogenetic MapXq13.1NCBI
HuRefX63,299,114 - 63,300,752 (-)NCBIHuRef
CHM1_1X69,371,994 - 69,373,632 (-)NCBICHM1_1
T2T-CHM13v2.0X68,691,490 - 68,693,528 (-)NCBIT2T-CHM13v2.0
P2ry4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X99,631,964 - 99,638,533 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX99,633,760 - 99,638,475 (-)EnsemblGRCm39 Ensembl
GRCm38X100,588,358 - 100,594,927 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX100,590,154 - 100,594,869 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X97,785,493 - 97,790,208 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X96,792,873 - 96,797,588 (-)NCBIMGSCv36mm8
CeleraX87,516,188 - 87,520,903 (-)NCBICelera
Cytogenetic MapXC3NCBI
cM MapX43.72NCBI
P2ry4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554759,800,541 - 9,802,055 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554759,794,538 - 9,802,055 (-)NCBIChiLan1.0ChiLan1.0
P2RY4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X69,935,449 - 69,937,488 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X69,939,051 - 69,941,090 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X59,526,621 - 59,528,248 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X69,585,984 - 69,587,611 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX69,586,340 - 69,587,437 (-)Ensemblpanpan1.1panPan2
P2RY4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X54,706,404 - 54,707,512 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX45,532,412 - 45,533,520 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X55,672,553 - 55,673,661 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X53,641,532 - 53,642,640 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X54,972,339 - 54,973,447 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X54,899,511 - 54,900,619 (-)NCBIUU_Cfam_GSD_1.0
P2ry4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X47,455,684 - 47,457,937 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367621,217,858 - 1,218,950 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367621,217,858 - 1,218,948 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
P2RY4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX56,279,346 - 56,286,400 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X56,284,736 - 56,285,833 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X63,479,522 - 63,480,619 (-)NCBISscrofa10.2Sscrofa10.2susScr3
P2RY4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X60,099,961 - 60,104,094 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX60,102,265 - 60,103,362 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660651,948,078 - 1,950,108 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
P2ry4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624903223,520 - 259,111 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624903221,985 - 257,903 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

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Variants in P2ry4
115 total Variants

Predicted Target Of
Summary Value
Count of predictions:75
Count of miRNA genes:66
Interacting mature miRNAs:71
Transcripts:ENSRNOT00000045907
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 48 113 91 90 59 25 59 6 216 96 93 44 60 31


1 to 23 of 23 rows
RefSeq Transcripts NM_031680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257093 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039100015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063280273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063280274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063280275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063280276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC141377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y11433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y14705 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 23 of 23 rows

Ensembl Acc Id: ENSRNOT00000045907   ⟹   ENSRNOP00000039027
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX65,686,252 - 65,721,748 (-)Ensembl
Rnor_6.0 EnsemblX70,426,951 - 70,428,364 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000096316   ⟹   ENSRNOP00000094459
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX65,683,232 - 65,721,748 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099755   ⟹   ENSRNOP00000085052
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX65,686,252 - 65,721,604 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112073   ⟹   ENSRNOP00000082634
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX65,683,232 - 65,721,748 (-)Ensembl
RefSeq Acc Id: NM_031680   ⟹   NP_113868
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X69,727,113 - 69,728,526 (-)NCBI
mRatBN7.2X65,687,032 - 65,688,445 (-)NCBI
Rnor_6.0X70,426,951 - 70,428,364 (-)NCBI
Rnor_5.0X71,296,545 - 71,329,324 (-)NCBI
RGSC_v3.4X88,589,534 - 88,590,947 (-)RGD
CeleraX66,045,899 - 66,047,312 (-)RGD
Sequence:
RefSeq Acc Id: XM_039100005   ⟹   XP_038955933
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X69,722,604 - 69,745,513 (-)NCBI
mRatBN7.2X65,681,680 - 65,705,437 (-)NCBI
RefSeq Acc Id: XM_039100006   ⟹   XP_038955934
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X69,722,604 - 69,752,295 (-)NCBI
mRatBN7.2X65,681,680 - 65,707,199 (-)NCBI
RefSeq Acc Id: XM_039100007   ⟹   XP_038955935
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X69,722,604 - 69,754,368 (-)NCBI
mRatBN7.2X65,681,680 - 65,717,382 (-)NCBI
RefSeq Acc Id: XM_039100009   ⟹   XP_038955937
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X69,722,604 - 69,757,726 (-)NCBI
mRatBN7.2X65,681,680 - 65,717,382 (-)NCBI
RefSeq Acc Id: XM_039100011   ⟹   XP_038955939
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X69,722,604 - 69,754,368 (-)NCBI
mRatBN7.2X65,681,680 - 65,717,382 (-)NCBI
RefSeq Acc Id: XM_039100012   ⟹   XP_038955940
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X69,722,604 - 69,757,726 (-)NCBI
mRatBN7.2X65,681,680 - 65,717,382 (-)NCBI
RefSeq Acc Id: XM_039100014   ⟹   XP_038955942
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X69,722,604 - 69,754,368 (-)NCBI
mRatBN7.2X65,681,680 - 65,717,382 (-)NCBI
RefSeq Acc Id: XM_039100015   ⟹   XP_038955943
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X69,722,604 - 69,757,726 (-)NCBI
mRatBN7.2X65,681,680 - 65,717,404 (-)NCBI
RefSeq Acc Id: XM_063280273   ⟹   XP_063136343
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X69,722,604 - 69,752,295 (-)NCBI
RefSeq Acc Id: XM_063280274   ⟹   XP_063136344
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X69,722,604 - 69,754,368 (-)NCBI
RefSeq Acc Id: XM_063280275   ⟹   XP_063136345
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X69,722,604 - 69,757,726 (-)NCBI
RefSeq Acc Id: XM_063280276   ⟹   XP_063136346
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X69,722,604 - 69,752,295 (-)NCBI
1 to 5 of 17 rows
1 to 5 of 17 rows
RefSeq Acc Id: NP_113868   ⟸   NM_031680
- UniProtKB: O35811 (UniProtKB/Swiss-Prot),   A6IQ78 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000039027   ⟸   ENSRNOT00000045907
RefSeq Acc Id: XP_038955943   ⟸   XM_039100015
- Peptide Label: isoform X1
- UniProtKB: O35811 (UniProtKB/Swiss-Prot),   A6IQ78 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955940   ⟸   XM_039100012
- Peptide Label: isoform X1
- UniProtKB: O35811 (UniProtKB/Swiss-Prot),   A6IQ78 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955937   ⟸   XM_039100009
- Peptide Label: isoform X1
- UniProtKB: O35811 (UniProtKB/Swiss-Prot),   A6IQ78 (UniProtKB/TrEMBL)
Name Modeler Protein Id AA Range Protein Structure
AF-O35811-F1-model_v2 AlphaFold O35811 1-361 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 35 of 35 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-2130 BioCyc
Ensembl Genes ENSRNOG00000002953 Ensembl
  ENSRNOG00000070777 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000045907.3 UniProtKB/Swiss-Prot
  ENSRNOT00000096316.1 UniProtKB/Swiss-Prot
  ENSRNOT00000099755.1 UniProtKB/Swiss-Prot
  ENSRNOT00000112073 ENTREZGENE
  ENSRNOT00000112073.1 UniProtKB/Swiss-Prot
  ENSRNOT00000121214 ENTREZGENE
  ENSRNOT00000125396 ENTREZGENE
  ENSRNOT00000133132 ENTREZGENE
  ENSRNOT00000134670 ENTREZGENE
  ENSRNOT00000147730 ENTREZGENE
  ENSRNOT00000167412 ENTREZGENE
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  P2Y4 UniProtKB/Swiss-Prot
KEGG Report rno:63843 UniProtKB/Swiss-Prot
NCBI Gene 63843 ENTREZGENE
PANTHER PTHR24231:SF21 UniProtKB/Swiss-Prot
  PURINOCEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen P2ry4 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  P2Y4PRNOCPTR UniProtKB/Swiss-Prot
  P2YPURNOCPTR UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002953 RatGTEx
  ENSRNOG00000070777 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
TIGR TC202238
UniProt A6IQ78 ENTREZGENE, UniProtKB/TrEMBL
  O35811 ENTREZGENE, UniProtKB/Swiss-Prot
1 to 35 of 35 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 P2ry4  pyrimidinergic receptor P2Y4  P2ry4  pyrimidinergic receptor P2Y, G-protein coupled, 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 P2ry4  pyrimidinergic receptor P2Y, G-protein coupled, 4    purinergic receptor P2Y, G-protein coupled 4  Name updated 1299863 APPROVED
2002-06-10 P2ry4  purinergic receptor P2Y, G-protein coupled 4      Name updated 70584 APPROVED

Note Type Note Reference
gene_cellular_localization localized to the apical plasma membrane and basolateral domains 628452
gene_expression mRNA present in holangiocytes, hepatocytes and epithelial cells 628452
gene_process may mediate vasomotor responses, neurotransmission, platelet aggregation, and secretion 628452
gene_regulation receptor activity is suramin-insensitive 628452