Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (1->4)-beta-D-glucan | multiple interactions | EXP | | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of P2RY4 mRNA | CTD | PMID:36331819 | 2,2',4,4'-Tetrabromodiphenyl ether | affects expression | EXP | | 6480464 | 2 more ... | CTD | PMID:30294300 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of P2RY4 mRNA | CTD | PMID:25975270 and PMID:26290441 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | P2ry4 (Rattus norvegicus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of P2RY4 mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | EXP | | 6480464 | Tetrachlorodibenzodioxin affects the expression of P2RY4 mRNA | CTD | PMID:26377647 | 2,6-dinitrotoluene | affects expression | ISO | P2ry4 (Rattus norvegicus) | 6480464 | 2 and 6-dinitrotoluene affects the expression of P2RY4 mRNA | CTD | PMID:21346803 | acetamide | increases expression | ISO | P2ry4 (Rattus norvegicus) | 6480464 | acetamide results in increased expression of P2RY4 mRNA | CTD | PMID:31881176 | acrylamide | increases expression | ISO | P2ry4 (Rattus norvegicus) | 6480464 | Acrylamide results in increased expression of P2RY4 mRNA | CTD | PMID:28959563 | ammonium chloride | affects expression | ISO | P2ry4 (Rattus norvegicus) | 6480464 | Ammonium Chloride affects the expression of P2RY4 mRNA | CTD | PMID:16483693 | ATP | multiple interactions | ISO | P2RY4 (Homo sapiens) | 6480464 | [Adenosine Triphosphate binds to and results in increased activity of P2RY4 protein] which results in increased abundance of Calcium more ... | CTD | PMID:12694404 | benzo[a]pyrene | decreases expression | ISO | P2RY4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of P2RY4 mRNA | CTD | PMID:22316170 | benzo[a]pyrene | decreases methylation | ISO | P2RY4 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of P2RY4 exon | CTD | PMID:27901495 | benzo[a]pyrene | affects methylation | ISO | P2RY4 (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of P2RY4 promoter | CTD | PMID:27901495 | bisphenol A | affects expression | ISO | P2ry4 (Rattus norvegicus) | 6480464 | bisphenol A affects the expression of P2RY4 mRNA | CTD | PMID:25181051 | bisphenol A | increases expression | ISO | P2ry4 (Rattus norvegicus) | 6480464 | bisphenol A results in increased expression of P2RY4 mRNA | CTD | PMID:30816183 more ... | calcium atom | multiple interactions | ISO | P2RY4 (Homo sapiens) | 6480464 | [Adenosine Triphosphate binds to and results in increased activity of P2RY4 protein] which results in increased abundance of Calcium and Trichloroethylene inhibits the reaction [[Adenosine Triphosphate binds to and results in increased activity of P2RY4 protein] which results in increased abundance of Calcium] | CTD | PMID:12694404 | calcium(0) | multiple interactions | ISO | P2RY4 (Homo sapiens) | 6480464 | [Adenosine Triphosphate binds to and results in increased activity of P2RY4 protein] which results in increased abundance of Calcium and Trichloroethylene inhibits the reaction [[Adenosine Triphosphate binds to and results in increased activity of P2RY4 protein] which results in increased abundance of Calcium] | CTD | PMID:12694404 | CGP 52608 | multiple interactions | ISO | P2RY4 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to P2RY4 gene] | CTD | PMID:28238834 | dextran sulfate | multiple interactions | EXP | | 6480464 | [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of P2RY4 mRNA | CTD | PMID:29950665 | disodium selenite | decreases expression | ISO | P2RY4 (Homo sapiens) | 6480464 | Sodium Selenite results in decreased expression of P2RY4 mRNA | CTD | PMID:18175754 | epoxiconazole | decreases expression | EXP | | 6480464 | epoxiconazole results in decreased expression of P2RY4 mRNA | CTD | PMID:35436446 | ethanol | multiple interactions | EXP | | 6480464 | [Carbon Tetrachloride co-treated with Ethanol] results in decreased expression of P2RY4 mRNA | CTD | PMID:30517762 | fenvalerate | increases expression | ISO | P2ry4 (Rattus norvegicus) | 6480464 | fenvalerate results in increased expression of P2RY4 mRNA | CTD | PMID:30307764 | fonofos | increases methylation | ISO | P2RY4 (Homo sapiens) | 6480464 | Fonofos results in increased methylation of P2RY4 promoter | CTD | PMID:22847954 | gentamycin | increases expression | ISO | P2ry4 (Rattus norvegicus) | 6480464 | Gentamicins results in increased expression of P2RY4 mRNA | CTD | PMID:33387578 | GTP | multiple interactions | ISO | P2ry4 (Rattus norvegicus) | 6480464 | Guanosine Triphosphate binds to and results in increased activity of P2RY4 protein | CTD | PMID:15654852 | lithium atom | increases expression | ISO | P2ry4 (Rattus norvegicus) | 6480464 | Lithium results in increased expression of P2RY4 mRNA | CTD | PMID:19244398 | lithium hydride | increases expression | ISO | P2ry4 (Rattus norvegicus) | 6480464 | Lithium results in increased expression of P2RY4 mRNA | CTD | PMID:19244398 | maneb | multiple interactions | EXP | | 6480464 | [Maneb co-treated with Paraquat] results in decreased expression of P2RY4 mRNA and Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of P2RY4 mRNA] | CTD | PMID:23963992 | melatonin | multiple interactions | EXP | | 6480464 | Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of P2RY4 mRNA] | CTD | PMID:23963992 | N-(3-oxododecanoyl)homoserine lactone | decreases expression | ISO | P2RY4 (Homo sapiens) | 6480464 | N-(3-oxododecanoyl)homoserine lactone results in decreased expression of P2RY4 mRNA | CTD | PMID:10496880 | paracetamol | affects expression | EXP | | 6480464 | Acetaminophen affects the expression of P2RY4 mRNA | CTD | PMID:17562736 | paracetamol | increases expression | ISO | P2ry4 (Rattus norvegicus) | 6480464 | Acetaminophen results in increased expression of P2RY4 mRNA | CTD | PMID:33387578 | paraquat | multiple interactions | EXP | | 6480464 | [Maneb co-treated with Paraquat] results in decreased expression of P2RY4 mRNA and Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of P2RY4 mRNA] | CTD | PMID:23963992 | parathion | increases methylation | ISO | P2RY4 (Homo sapiens) | 6480464 | Parathion results in increased methylation of P2RY4 promoter | CTD | PMID:22847954 | perfluorooctane-1-sulfonic acid | multiple interactions | EXP | | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of P2RY4 mRNA | CTD | PMID:36331819 | pirinixic acid | decreases expression | EXP | | 6480464 | pirinixic acid results in decreased expression of P2RY4 mRNA | CTD | PMID:17950772 | pregnenolone 16alpha-carbonitrile | decreases expression | EXP | | 6480464 | Pregnenolone Carbonitrile results in decreased expression of P2RY4 mRNA | CTD | PMID:28903501 | tamoxifen | decreases expression | EXP | | 6480464 | Tamoxifen results in decreased expression of P2RY4 mRNA | CTD | PMID:25123088 | terbufos | increases methylation | ISO | P2RY4 (Homo sapiens) | 6480464 | terbufos results in increased methylation of P2RY4 promoter | CTD | PMID:22847954 | tetrachloromethane | affects expression | ISO | P2ry4 (Rattus norvegicus) | 6480464 | Carbon Tetrachloride affects the expression of P2RY4 mRNA | CTD | PMID:12734012 | tetrachloromethane | multiple interactions | EXP | | 6480464 | [Carbon Tetrachloride co-treated with Ethanol] results in decreased expression of P2RY4 mRNA | CTD | PMID:30517762 | tetrachloromethane | decreases expression | ISO | P2ry4 (Rattus norvegicus) | 6480464 | Carbon Tetrachloride results in decreased expression of P2RY4 mRNA | CTD | PMID:31150632 | thioacetamide | increases expression | ISO | P2ry4 (Rattus norvegicus) | 6480464 | Thioacetamide results in increased expression of P2RY4 mRNA | CTD | PMID:23411599 | titanium dioxide | increases expression | EXP | | 6480464 | titanium dioxide results in increased expression of P2RY4 mRNA | CTD | PMID:29264374 | titanium dioxide | multiple interactions | EXP | | 6480464 | [titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in increased expression of P2RY4 mRNA | CTD | PMID:29950665 | trichloroethene | multiple interactions | ISO | P2RY4 (Homo sapiens) | 6480464 | Trichloroethylene inhibits the reaction [[Adenosine Triphosphate binds to and results in increased activity of P2RY4 protein] which results in increased abundance of Calcium] | CTD | PMID:12694404 | trichloroethene | decreases activity | ISO | P2RY4 (Homo sapiens) | 6480464 | Trichloroethylene results in decreased activity of P2RY4 protein | CTD | PMID:12694404 | triptonide | increases expression | EXP | | 6480464 | triptonide results in increased expression of P2RY4 mRNA | CTD | PMID:33045310 | UTP | multiple interactions | ISO | P2ry4 (Rattus norvegicus) | 6480464 | Uridine Triphosphate binds to and results in increased activity of P2RY4 protein | CTD | PMID:15654852 | valproic acid | increases methylation | ISO | P2RY4 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of P2RY4 gene | CTD | PMID:29154799 | | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Gene Ontology Annotations Click to see Annotation Detail View
Biological Process
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Molecular Function
Phenotype Annotations Click to see Annotation Detail View
Mammalian Phenotype
Disease Annotations
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Gene-Chemical Interaction Annotations
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Biological Process
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Molecular Function
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Mammalian Phenotype
References
References - curated
| # | Reference Title | Reference Citation |
| 1. | Electronic Transfer of Homolog Data | MGD and Homologene mouse data transfer |
| 2. | MGDs mouse GO annotations | MGD data from the GO Consortium |
| 3. | Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. | Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73. |
| 4. | Mouse MP Annotation Import Pipeline | RGD automated import pipeline |
| 5. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
Additional References at PubMed
| PMID:10349636 | PMID:11042159 | PMID:11076861 | PMID:11217851 | PMID:11259526 | PMID:11290369 | PMID:12477932 | PMID:12644577 | PMID:12814360 | PMID:15670583 | PMID:15718265 | PMID:16141072 |
| PMID:16141073 | PMID:16602821 | PMID:16980298 | PMID:19250649 | PMID:19423692 | PMID:19889460 | PMID:19890001 | PMID:20630102 | PMID:21413988 | PMID:21873635 | PMID:22437266 | PMID:22865387 |
| PMID:23479225 | PMID:24001770 | PMID:25595790 | PMID:26972684 | PMID:27855539 | PMID:28322086 | PMID:36248854 | PMID:36532779 |
Genomics
Comparative Map Data
| P2ry4 (Mus musculus - house mouse) |
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| P2RY4 (Homo sapiens - human) |
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| P2ry4 (Rattus norvegicus - Norway rat) |
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| P2ry4 (Chinchilla lanigera - long-tailed chinchilla) |
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| P2RY4 (Pan paniscus - bonobo/pygmy chimpanzee) |
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| P2RY4 (Canis lupus familiaris - dog) |
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| P2ry4 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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| P2RY4 (Sus scrofa - pig) |
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| P2RY4 (Chlorocebus sabaeus - green monkey) |
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| P2ry4 (Heterocephalus glaber - naked mole-rat) |
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Variants
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Variants in P2ry4
151 total Variants 
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