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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:N-(3-oxododecanoyl)homoserine lactone
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Accession:CHEBI:29639 term browser browse the term
Definition:A N-acyl homoserine lactone that is the monocarboxylic acid amide arising from formal condensation of homoserine lactone with 3-oxododecanoic acid.
Synonyms:exact_synonym: 3-oxo-N-(2-oxotetrahydrofuran-3-yl)dodecanamide
 related_synonym: 3-Oxo-N-(tetrahydro-2-oxo-3-furanyl)dodecanamide;   3-oxo-C12-AHL;   3-oxo-C12-HSL;   Formula=C16H27NO4;   InChI=1S/C16H27NO4/c1-2-3-4-5-6-7-8-9-13(18)12-15(19)17-14-10-11-21-16(14)20/h14H,2-12H2,1H3,(H,17,19);   InChIKey=PHSRRHGYXQCRPU-UHFFFAOYSA-N;   N-(3-ketododecanoyl)homoserine lactone;   PA Autoinducer;   Pseudomonas aeruginosa autoinducer;   SMILES=CCCCCCCCCC(=O)CC(=O)NC1CCOC1=O
 xref: CAS:152833-54-0;   KEGG:C11840;   LIPID_MAPS_instance:LMFA08030001
 xref_mesh: MESH:C109860
 xref: PMID:12837389;   PMID:14500500;   PMID:15060029;   PMID:15328111;   PMID:16984415;   PMID:17400249;   PMID:18178738;   PMID:18452426;   PMID:18465897;   PMID:21190852;   PMID:21305014;   PMID:7878006;   PMID:8830697;   Reaxys:10100143


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N-(3-oxododecanoyl)homoserine lactone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO N-(3-oxododecanoyl)homoserine lactone results in increased activity of CASP3 protein CTD PMID:25627690 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 increases activity ISO N-(3-oxododecanoyl)homoserine lactone results in increased activity of CASP7 protein CTD PMID:25627690 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G P2ry2 purinergic receptor P2Y2 multiple interactions
decreases expression		 ISO Ibuprofen inhibits the reaction [N-(3-oxododecanoyl)homoserine lactone results in decreased expression of P2RY2 mRNA] CTD PMID:10496880 NCBI chr 1:155,352,050...155,367,423
Ensembl chr 1:155,351,165...155,367,632 		JBrowse link
G P2ry4 pyrimidinergic receptor P2Y4 decreases expression ISO N-(3-oxododecanoyl)homoserine lactone results in decreased expression of P2RY4 mRNA CTD PMID:10496880 NCBI chr  X:65,681,680...65,717,404
Ensembl chr  X:65,683,232...65,721,748 		JBrowse link
G Pon2 paraoxonase 2 increases response to substance ISO PON2 protein results in increased susceptibility to N-(3-oxododecanoyl)homoserine lactone CTD PMID:25627690 NCBI chr 4:33,389,702...33,425,186
Ensembl chr 4:33,389,714...33,425,248 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19932
    role 19904
      biological role 19902
        molecular messenger 18693
          signalling molecule 10569
            autoinducer 5
              N-acyl homoserine lactone 5
                N-(3-oxododecanoyl)homoserine lactone 5
                  N-(3-oxododecanoyl)-D-homoserine lactone 0
                  N-(3-oxododecanoyl)-L-homoserine lactone 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19932
    subatomic particle 19930
      composite particle 19930
        hadron 19930
          baryon 19930
            nucleon 19930
              atomic nucleus 19930
                atom 19930
                  main group element atom 19876
                    p-block element atom 19876
                      carbon group element atom 19816
                        carbon atom 19812
                          organic molecular entity 19812
                            heteroorganic entity 19559
                              organochalcogen compound 19317
                                organooxygen compound 19231
                                  carbon oxoacid 18687
                                    carboxylic acid 18684
                                      carboacyl group 17725
                                        univalent carboacyl group 17725
                                          carbamoyl group 17579
                                            carboxamide 17579
                                              monocarboxylic acid amide 15749
                                                N-acyl homoserine lactone 5
                                                  N-(3-oxododecanoyl)homoserine lactone 5
                                                    N-(3-oxododecanoyl)-D-homoserine lactone 0
                                                    N-(3-oxododecanoyl)-L-homoserine lactone 0
paths to the root