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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:N-(3-oxododecanoyl)homoserine lactone
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Accession:CHEBI:29639 term browser browse the term
Definition:A N-acyl homoserine lactone that is the monocarboxylic acid amide arising from formal condensation of homoserine lactone with 3-oxododecanoic acid.
Synonyms:exact_synonym: 3-oxo-N-(2-oxotetrahydrofuran-3-yl)dodecanamide
 related_synonym: 3-Oxo-N-(tetrahydro-2-oxo-3-furanyl)dodecanamide;   3-oxo-C12-AHL;   3-oxo-C12-HSL;   Formula=C16H27NO4;   InChI=1S/C16H27NO4/c1-2-3-4-5-6-7-8-9-13(18)12-15(19)17-14-10-11-21-16(14)20/h14H,2-12H2,1H3,(H,17,19);   InChIKey=PHSRRHGYXQCRPU-UHFFFAOYSA-N;   N-(3-ketododecanoyl)homoserine lactone;   PA Autoinducer;   Pseudomonas aeruginosa autoinducer;   SMILES=CCCCCCCCCC(=O)CC(=O)NC1CCOC1=O
 xref: CAS:152833-54-0;   KEGG:C11840;   LIPID_MAPS_instance:LMFA08030001
 xref_mesh: MESH:C109860
 xref: PMID:12837389;   PMID:14500500;   PMID:15060029;   PMID:15328111;   PMID:16984415;   PMID:17400249;   PMID:18178738;   PMID:18452426;   PMID:18465897;   PMID:21190852;   PMID:21305014;   PMID:7878006;   PMID:8830697;   Reaxys:10100143


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N-(3-oxododecanoyl)homoserine lactone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO N-(3-oxododecanoyl)homoserine lactone results in increased activity of CASP3 protein CTD PMID:25627690 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp7 caspase 7 increases activity ISO N-(3-oxododecanoyl)homoserine lactone results in increased activity of CASP7 protein CTD PMID:25627690 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G P2ry2 purinergic receptor P2Y2 multiple interactions
decreases expression
ISO Ibuprofen inhibits the reaction [N-(3-oxododecanoyl)homoserine lactone results in decreased expression of P2RY2 mRNA] CTD PMID:10496880 NCBI chr 1:166,031,228...166,045,423
Ensembl chr 1:166,031,272...166,037,424
JBrowse link
G P2ry4 pyrimidinergic receptor P2Y4 decreases expression ISO N-(3-oxododecanoyl)homoserine lactone results in decreased expression of P2RY4 mRNA CTD PMID:10496880 NCBI chr  X:70,421,599...70,447,109
Ensembl chr  X:70,426,951...70,428,364
JBrowse link
G Pon2 paraoxonase 2 increases response to substance ISO PON2 protein results in increased susceptibility to N-(3-oxododecanoyl)homoserine lactone CTD PMID:25627690 NCBI chr 4:30,344,705...30,380,119
Ensembl chr 4:30,344,709...30,380,119
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19840
    role 19790
      biological role 19790
        molecular messenger 18288
          signalling molecule 8254
            autoinducer 5
              N-acyl homoserine lactone 5
                N-(3-oxododecanoyl)homoserine lactone 5
                  N-(3-oxododecanoyl)-D-homoserine lactone 0
                  N-(3-oxododecanoyl)-L-homoserine lactone 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19840
    subatomic particle 19838
      composite particle 19838
        hadron 19838
          baryon 19838
            nucleon 19838
              atomic nucleus 19838
                atom 19838
                  main group element atom 19730
                    p-block element atom 19730
                      carbon group element atom 19635
                        carbon atom 19624
                          organic molecular entity 19624
                            organic group 18537
                              organic divalent group 18528
                                organodiyl group 18528
                                  carbonyl group 18436
                                    carbonyl compound 18436
                                      carboxylic acid 18113
                                        carboacyl group 17377
                                          univalent carboacyl group 17377
                                            carbamoyl group 17163
                                              carboxamide 17163
                                                monocarboxylic acid amide 14583
                                                  N-acyl homoserine lactone 5
                                                    N-(3-oxododecanoyl)homoserine lactone 5
                                                      N-(3-oxododecanoyl)-D-homoserine lactone 0
                                                      N-(3-oxododecanoyl)-L-homoserine lactone 0
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