Kcnj11 (potassium inwardly-rectifying channel, subfamily J, member 11) - Rat Genome Database

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Gene: Kcnj11 (potassium inwardly-rectifying channel, subfamily J, member 11) Rattus norvegicus
Analyze
Symbol: Kcnj11
Name: potassium inwardly-rectifying channel, subfamily J, member 11
RGD ID: 69247
Description: Enables several functions, including ankyrin binding activity; monoatomic cation transmembrane transporter activity; and transmembrane transporter binding activity. Involved in several processes, including cellular response to nicotine; potassium ion import across plasma membrane; and response to ischemia. Located in several cellular components, including axolemma; cell body fiber; and cytoplasmic vesicle. Part of inward rectifying potassium channel. Is active in glutamatergic synapse and presynaptic membrane. Biomarker of brain disease (multiple); glucose metabolism disease (multiple); hypertension; and sciatic neuropathy. Human ortholog(s) of this gene implicated in glucose metabolism disease (multiple). Orthologous to human KCNJ11 (potassium inwardly rectifying channel subfamily J member 11); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; altered insulin secretion pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ATP-sensitive inward rectifier potassium channel 11; BIR; inward rectifier K(+) channel Kir6.2; Kir6.2; potassium channel, inwardly rectifying subfamily J member 11; potassium channel, inwardly rectifying subfamily J, member 11; potassium inwardly rectifying channel, subfamily J, member 11; potassium inwardly-rectifying channel subfamily J member 11; potassium voltage-gated channel subfamily J member 11
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Kcnj11em5Mcwi ; Kcnj11em9Mcwi
Genetic Models: SS-Kcnj11em5Mcwi ; SS-Kcnj11em9Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,727,473 - 105,731,167 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1105,727,570 - 105,731,169 (-)EnsemblGRCr8
mRatBN7.2196,591,048 - 96,594,574 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl196,591,049 - 96,594,082 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1101,977,177 - 101,980,211 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01110,449,162 - 110,452,195 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,739,531 - 103,742,564 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01102,103,093 - 102,107,134 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1102,103,094 - 102,106,127 (-)Ensemblrn6Rnor6.0
Rnor_5.01103,186,859 - 103,190,535 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4196,614,960 - 96,617,993 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera190,842,071 - 90,845,104 (-)NCBICelera
RGSC_v3.1196,693,070 - 96,696,104 (-)NCBI
Cytogenetic Map1q22NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrophenol  (ISO)
2-deoxy-D-glucose  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP,ISO)
adenosine 5'-monophosphate  (ISO)
AICA ribonucleotide  (ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
ATP  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
calcium atom  (ISO)
calcium(0)  (ISO)
cantharidin  (ISO)
carvedilol  (ISO)
chlorpropamide  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cocaine  (ISO)
creatine  (ISO)
dantrolene  (ISO)
dexamethasone  (EXP)
diazoxide  (ISO)
diethylstilbestrol  (EXP)
dimethylarsinic acid  (EXP)
dioxygen  (EXP)
dobutamine  (ISO)
doxorubicin  (EXP)
ethylparaben  (ISO)
fenvalerate  (EXP)
flavonoids  (EXP)
folic acid  (ISO)
formaldehyde  (EXP)
genistein  (ISO)
gliclazide  (ISO)
glimepiride  (ISO)
glyburide  (ISO)
lovastatin  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mitiglinide  (ISO)
Moniliformin  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
oxidopamine  (EXP)
paracetamol  (ISO)
pentachlorophenol  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
phlorizin  (ISO)
picrotoxin  (EXP)
Pinacidil  (ISO)
pioglitazone  (ISO)
potassium atom  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
resveratrol  (ISO)
rotenone  (EXP,ISO)
rubidium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium disulfite  (EXP)
sulfur dioxide  (EXP)
sunitinib  (ISO)
Terfenadine  (EXP)
testosterone  (EXP)
titanium dioxide  (ISO)
tolbutamide  (ISO)
triclosan  (ISO)
triptonide  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway   (ISO)
altered insulin secretion pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
forkhead class A signaling pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway   (ISO)
insulin secretion pathway  (TAS)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway   (ISO)
type 2 diabetes mellitus pathway  (IEA,ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. A syndrome of congenital hyperinsulinism and rhabdomyolysis is caused by KCNJ11 mutation. Albaqumi M, etal., J Med Genet. 2014 Apr;51(4):271-4. doi: 10.1136/jmedgenet-2013-102085. Epub 2014 Jan 13.
2. Endosomal KATP channels as a reservoir after myocardial ischemia: a role for SUR2 subunits. Bao L, etal., Am J Physiol Heart Circ Physiol. 2011 Jan;300(1):H262-70. doi: 10.1152/ajpheart.00857.2010. Epub 2010 Oct 22.
3. Identification of two novel frameshift mutations in the KCNJ11 gene in two Italian patients affected by Congenital Hyperinsulinism of Infancy. Biagiotti L, etal., Exp Mol Pathol. 2007 Aug;83(1):59-64. Epub 2007 Jan 17.
4. KATP channel conductance of descending vasa recta pericytes. Cao C, etal., Am J Physiol Renal Physiol. 2005 Dec;289(6):F1235-45. Epub 2005 Jul 26.
5. Molecular basis of ATP-sensitive K+ channels in rat vascular smooth muscles. Cao K, etal., Biochem Biophys Res Commun 2002 Aug 16;296(2):463-9.
6. Conserved functional consequences of disease-associated mutations in the slide helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel. Cooper PE, etal., J Biol Chem. 2017 Oct 20;292(42):17387-17398. doi: 10.1074/jbc.M117.804971. Epub 2017 Aug 23.
7. An in-frame deletion in Kir6.2 (KCNJ11) causing neonatal diabetes reveals a site of interaction between Kir6.2 and SUR1. Craig TJ, etal., J Clin Endocrinol Metab. 2009 Jul;94(7):2551-7. Epub 2009 Apr 7.
8. Subunit composition of ATP-sensitive potassium channels in mitochondria of rat hearts. Cuong DV, etal., Mitochondrion. 2005 Apr;5(2):121-33.
9. The glycolytic enzymes, glyceraldehyde-3-phosphate dehydrogenase, triose-phosphate isomerase, and pyruvate kinase are components of the K(ATP) channel macromolecular complex and regulate its function. Dhar-Chowdhury P, etal., J Biol Chem. 2005 Nov 18;280(46):38464-70. Epub 2005 Sep 16.
10. Congenital hyperinsulinism: clinical and molecular analysis of a large Italian cohort. Faletra F, etal., Gene. 2013 May 25;521(1):160-5. doi: 10.1016/j.gene.2013.03.021. Epub 2013 Mar 16.
11. Type 2 diabetes-associated missense polymorphisms KCNJ11 E23K and ABCC8 A1369S influence progression to diabetes and response to interventions in the Diabetes Prevention Program. Florez JC, etal., Diabetes. 2007 Feb;56(2):531-6.
12. Effects of a sucrose-enriched diet on the pattern of gene expression, contraction and Ca(2+) transport in Goto-Kakizaki type 2 diabetic rat heart. Gaber EM, etal., Exp Physiol. 2014 Jun;99(6):881-93. doi: 10.1113/expphysiol.2013.077594. Epub 2014 Mar 28.
13. Iptakalim, opener of K(ATP), reverses the enhanced expression of genes encoding K(ATP) subunits in spontaneously hypertensive rats. Gao M, etal., Life Sci. 2005 Oct 14;77(22):2743-51.
14. Regulation of ATP-sensitive K+ channels by caveolin-enriched microdomains in cardiac myocytes. Garg V, etal., Cardiovasc Res. 2009 Apr 1;82(1):51-8. doi: 10.1093/cvr/cvp039. Epub 2009 Jan 30.
15. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
16. Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes. Girard CA, etal., J Clin Invest. 2009 Jan;119(1):80-90. doi: 10.1172/JCI35772. Epub 2008 Dec 8.
17. KCNJ11 activating mutations are associated with developmental delay, epilepsy and neonatal diabetes syndrome and other neurological features. Gloyn AL, etal., Eur J Hum Genet. 2006 Jul;14(7):824-30. Epub 2006 May 3.
18. Mutations in the genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) in diabetes mellitus and hyperinsulinism. Gloyn AL, etal., Hum Mutat. 2006 Mar;27(3):220-31.
19. Permanent neonatal diabetes due to paternal germline mosaicism for an activating mutation of the KCNJ11 Gene encoding the Kir6.2 subunit of the beta-cell potassium adenosine triphosphate channel. Gloyn AL, etal., J Clin Endocrinol Metab. 2004 Aug;89(8):3932-5.
20. Activating mutations in the gene encoding the ATP-sensitive potassium-channel subunit Kir6.2 and permanent neonatal diabetes. Gloyn AL, etal., N Engl J Med. 2004 Apr 29;350(18):1838-49.
21. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
22. Reduced expression of the KATP channel subunit, Kir6.2, is associated with decreased expression of neuropeptide Y and agouti-related protein in the hypothalami of Zucker diabetic fatty rats. Gyte A, etal., J Neuroendocrinol. 2007 Dec;19(12):941-51.
23. Channel regulation of glucose sensing in the pancreatic beta-cell. Hiriart M and Aguilar-Bryan L, Am J Physiol Endocrinol Metab. 2008 Dec;295(6):E1298-306. Epub 2008 Oct 21.
24. Heterogeneity of ATP-sensitive K+ channels in cardiac myocytes: enrichment at the intercalated disk. Hong M, etal., J Biol Chem. 2012 Nov 30;287(49):41258-67. doi: 10.1074/jbc.M112.412122. Epub 2012 Oct 12.
25. Disruption of sarcolemmal ATP-sensitive potassium channel activity impairs the cardiac response to systolic overload. Hu X, etal., Circ Res. 2008 Oct 24;103(9):1009-17. doi: 10.1161/CIRCRESAHA.107.170795. Epub 2008 Sep 18.
26. Pregabalin attenuates excitotoxicity in diabetes. Huang CW, etal., PLoS One. 2013 Jun 13;8(6):e65154. doi: 10.1371/journal.pone.0065154. Print 2013.
27. A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channels. Inagaki N, etal., Neuron. 1996 May;16(5):1011-7.
28. Angiotensin II and tumour necrosis factor alpha as mediators of ATP-dependent potassium channel remodelling in post-infarction heart failure. Isidoro Tavares N, etal., Cardiovasc Res. 2009 Sep 1;83(4):726-36. doi: 10.1093/cvr/cvp162. Epub 2009 May 21.
29. The pattern of ATP-sensitive K+ channel subunits, Kir6.2 and SUR1 mRNA expressions in DG region is different from those in CA1-3 regions of chronic epilepsy induced by picrotoxin in rats. Jiang K, etal., Neuropathology. 2007 Dec;27(6):531-8.
30. Dual role of K ATP channel C-terminal motif in membrane targeting and metabolic regulation. Kline CF, etal., Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16669-74. doi: 10.1073/pnas.0907138106. Epub 2009 Sep 15.
31. Glucose deprivation regulates KATP channel trafficking via AMP-activated protein kinase in pancreatic beta-cells. Lim A, etal., Diabetes. 2009 Dec;58(12):2813-9. doi: 10.2337/db09-0600. Epub 2009 Aug 31.
32. Sulfonylurea receptors regulate the channel pore in ATP-sensitive potassium channels via an intersubunit salt bridge. Lodwick D, etal., Biochem J. 2014 Dec 15;464(3):343-54. doi: 10.1042/BJ20140273.
33. Detection of K(ATP) channels subunits in human term placental explants and evaluation of their implication in human placental lactogen (hPL) and human chorionic gonadotropin (hCG) release. Lybaert P, etal., Placenta. 2013 Jun;34(6):467-73. doi: 10.1016/j.placenta.2013.03.006. Epub 2013 Apr 13.
34. Severe congenital hyperinsulinism caused by a mutation in the Kir6.2 subunit of the adenosine triphosphate-sensitive potassium channel impairing trafficking and function. Marthinet E, etal., J Clin Endocrinol Metab. 2005 Sep;90(9):5401-6. Epub 2005 Jul 5.
35. A role for ATP-sensitive potassium channels in male sexual behavior. McDevitt MA, etal., Horm Behav. 2009 Feb;55(2):366-74. Epub 2008 Sep 16.
36. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
37. Clinical and genetic evaluation of patients with KATP channel mutations from the German registry for congenital hyperinsulinism. Mohnike K, etal., Horm Res Paediatr. 2014;81(3):156-68. doi: 10.1159/000356905. Epub 2014 Jan 7.
38. Regulated expression of adenosine triphosphate-sensitive potassium channel subunits in pancreatic beta-cells. Moritz W, etal., Endocrinology 2001 Jan;142(1):129-38.
39. Immunolocalization of KATP channel subunits in mouse and rat cardiac myocytes and the coronary vasculature. Morrissey A, etal., BMC Physiol. 2005 Jan 12;5(1):1.
40. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
41. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
42. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
43. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
44. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
45. Proximal C-terminal domain of sulphonylurea receptor 2A interacts with pore-forming Kir6 subunits in KATP channels. Rainbow RD, etal., Biochem J. 2004 Apr 1;379(Pt 1):173-81.
46. GOA pipeline RGD automated data pipeline
47. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
48. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
49. Current status of the E23K Kir6.2 polymorphism: implications for type-2 diabetes. Riedel MJ, etal., Hum Genet. 2005 Feb;116(3):133-45. Epub 2004 Nov 23.
50. Metabolic gene expression changes in the hippocampus of obese epileptic male rats in the pilocarpine model of temporal lobe epilepsy. Ruiz N, etal., Brain Res. 2011 Dec 2;1426:86-95. Epub 2011 Oct 8.
51. Chronic nicotine induces hypoxia inducible factor-2alpha in perinatal rat adrenal chromaffin cells: role in transcriptional upregulation of KATP channel subunit Kir6.2. Salman S, etal., Am J Physiol Cell Physiol. 2012 May 15;302(10):C1531-8. doi: 10.1152/ajpcell.00052.2012. Epub 2012 Mar 7.
52. Nicorandil ameliorates ischaemia-reperfusion injury in the rat kidney. Shimizu S, etal., Br J Pharmacol. 2011 May;163(2):272-82. doi: 10.1111/j.1476-5381.2011.01231.x.
53. Distribution of Kir6.0 and SUR2 ATP-sensitive potassium channel subunits in isolated ventricular myocytes. Singh H, etal., J Mol Cell Cardiol. 2003 May;35(5):445-59.
54. Genetic analysis of Italian patients with congenital hyperinsulinism of infancy. Sogno Valin P, etal., Horm Res Paediatr. 2013;79(4):236-42. doi: 10.1159/000350827. Epub 2013 May 1.
55. Expression of functional Kir6.1 channels regulates glutamate release at CA3 synapses in generation of epileptic form of seizures. Soundarapandian MM, etal., J Neurochem. 2007 Dec;103(5):1982-8. doi: 10.1111/j.1471-4159.2007.04883.x. Epub 2007 Sep 18.
56. Association of 18 Confirmed Susceptibility Loci for Type 2 Diabetes with Indices of Insulin Release, Proinsulin Conversion, and Insulin Sensitivity in 5 327 Non-diabetic Finnish Men. Stancakova A, etal., Diabetes. 2009 Jun 5.
57. Role for SUR2A in coupling cardiac K(ATP) channels to caveolin-3. Sun W and Hu K, Cell Physiol Biochem. 2010;25(4-5):409-18. doi: 10.1159/000303045. Epub 2010 Mar 23.
58. Arylcyanoguanidines as activators of Kir6.2/SUR1K ATP channels and inhibitors of insulin release. Tagmose TM, etal., J Med Chem. 2004 Jun 3;47(12):3202-11.
59. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
60. Rat inwardly rectifying potassium channel Kir6.2: cloning electrophysiological characterization, and decreased expression in pancreatic islets of male Zucker diabetic fatty rats. Tokuyama Y, etal., Biochem Biophys Res Commun 1996 Mar 27;220(3):532-8.
61. The A3 adenosine receptor agonist CP-532,903 [N6-(2,5-dichlorobenzyl)-3'-aminoadenosine-5'-N-methylcarboxamide] protects against myocardial ischemia/reperfusion injury via the sarcolemmal ATP-sensitive potassium channel. Wan TC, etal., J Pharmacol Exp Ther. 2008 Jan;324(1):234-43. Epub 2007 Sep 28.
62. Studies of ATP-sensitive potassium channels on 6-hydroxydopamine and haloperidol rat models of Parkinson's disease: implications for treating Parkinson's disease? Wang S, etal., Neuropharmacology. 2005 Jun;48(7):984-92.
63. Effect of electronic stimulation at Neiguan (PC 6) acupoint on gene expression of adenosine triphosphate-sensitive potassium channel and protein kinases in rats with myocardial ischemia. Wang W, etal., J Tradit Chin Med. 2015 Oct;35(5):577-82.
64. Identification of two types of ATP-sensitive K+ channels in rat ventricular myocytes. Wu SN, etal., Life Sci. 2007 Jan 2;80(4):378-87. Epub 2006 Oct 17.
65. Role of Hsp90 in biogenesis of the beta-cell ATP-sensitive potassium channel complex. Yan FF, etal., Mol Biol Cell. 2010 Jun 15;21(12):1945-54. Epub 2010 Apr 28.
66. Alterations in the expression of ATP-sensitive potassium channel subunit mRNA after acute peripheral nerve and spinal cord injury. Yin XF, etal., Eur Neurol. 2007;57(1):4-10. Epub 2006 Nov 14.
67. Neuroprotective effects of 17beta-estradiol associate with KATP in rat brain. Zhang D, etal., Neuroreport. 2012 Nov 14;23(16):952-7. doi: 10.1097/WNR.0b013e3283598de6.
68. The E23K variation in the KCNJ11 gene is associated with type 2 diabetes in Chinese and East Asian population. Zhou D, etal., J Hum Genet. 2009 Jun 5.
69. Different localization of ATP sensitive K+ channel subunits in rat testis. Zhou M, etal., Anat Rec (Hoboken). 2011 Apr;294(4):729-37. doi: 10.1002/ar.21348. Epub 2011 Feb 15.
70. Localization of pore-forming subunit of the ATP-sensitive K(+)-channel, Kir6.2, in rat brain neurons and glial cells. Zhou M, etal., Brain Res Mol Brain Res 2002 May 30;101(1-2):23-32.
71. ATP-sensitive K+-channel subunits on the mitochondria and endoplasmic reticulum of rat cardiomyocytes. Zhou M, etal., J Histochem Cytochem. 2005 Dec;53(12):1491-500. Epub 2005 Jun 27.
72. Engineered Kir6.2 mutations that correct the trafficking defect of K(ATP) channels caused by specific SUR1 mutations. Zhou Q, etal., Channels (Austin). 2013 Jul-Aug;7(4):313-7. Epub 2013 May 21.
73. KATP channel subunits in rat dorsal root ganglia: alterations by painful axotomy. Zoga V, etal., Mol Pain. 2010 Jan 26;6:6. doi: 10.1186/1744-8069-6-6.
Additional References at PubMed
PMID:8798681   PMID:8889548   PMID:8923010   PMID:12860923   PMID:14592811   PMID:15044189   PMID:15166124   PMID:15528203   PMID:15583126   PMID:15613469   PMID:15739238   PMID:15775962  
PMID:15784703   PMID:16085792   PMID:16537788   PMID:16731837   PMID:16956886   PMID:17311891   PMID:18006464   PMID:18073297   PMID:18250167   PMID:18776135   PMID:19141293   PMID:19151370  
PMID:19464385   PMID:19933268   PMID:20008464   PMID:20456845   PMID:20610380   PMID:21145327   PMID:21193530   PMID:21321069   PMID:21474909   PMID:21482559   PMID:21654216   PMID:22144717  
PMID:22257425   PMID:22480512   PMID:22636679   PMID:22802363   PMID:23219002   PMID:23418587   PMID:23700433   PMID:24014680   PMID:24429282   PMID:24480471   PMID:25073062   PMID:27430376  
PMID:28082085   PMID:28092267   PMID:30074836   PMID:30868916  


Genomics

Comparative Map Data
Kcnj11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,727,473 - 105,731,167 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1105,727,570 - 105,731,169 (-)EnsemblGRCr8
mRatBN7.2196,591,048 - 96,594,574 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl196,591,049 - 96,594,082 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1101,977,177 - 101,980,211 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01110,449,162 - 110,452,195 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,739,531 - 103,742,564 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01102,103,093 - 102,107,134 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1102,103,094 - 102,106,127 (-)Ensemblrn6Rnor6.0
Rnor_5.01103,186,859 - 103,190,535 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4196,614,960 - 96,617,993 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera190,842,071 - 90,845,104 (-)NCBICelera
RGSC_v3.1196,693,070 - 96,696,104 (-)NCBI
Cytogenetic Map1q22NCBI
KCNJ11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381117,385,248 - 17,389,346 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1117,365,172 - 17,389,353 (-)Ensemblhg38GRCh38
GRCh371117,406,795 - 17,410,893 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361117,363,371 - 17,366,782 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341117,364,788 - 17,366,737NCBI
Celera1117,536,622 - 17,540,705 (-)NCBICelera
Cytogenetic Map11p15.1NCBI
HuRef1117,090,617 - 17,094,700 (-)NCBIHuRef
CHM1_11117,406,598 - 17,410,681 (-)NCBICHM1_1
T2T-CHM13v2.01117,482,848 - 17,486,946 (-)NCBIT2T-CHM13v2.0
Kcnj11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,746,545 - 45,750,215 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl745,743,377 - 45,750,188 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38746,097,123 - 46,100,952 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl746,093,953 - 46,100,764 (-)Ensemblmm10GRCm38
MGSCv37753,352,532 - 53,355,607 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36745,965,204 - 45,968,279 (-)NCBIMGSCv36mm8
Celera741,570,483 - 41,573,555 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.66NCBI
Kcnj11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541432,210,545 - 32,211,717 (-)Ensembl
ChiLan1.0NW_00495541432,209,426 - 32,212,424 (-)NCBIChiLan1.0ChiLan1.0
KCNJ11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2919,706,414 - 19,723,055 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11119,679,358 - 19,683,468 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01117,440,522 - 17,444,075 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11117,125,885 - 17,129,579 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1117,127,557 - 17,128,729 (-)EnsemblpanPan2panpan1.1
KCNJ11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12139,953,461 - 39,957,615 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2139,955,551 - 39,956,723 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2139,454,228 - 39,457,833 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02141,059,361 - 41,062,966 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2141,060,903 - 41,062,075 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12140,072,057 - 40,075,662 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02140,279,502 - 40,283,108 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02140,618,209 - 40,621,814 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Kcnj11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494745,651,254 - 45,654,240 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365281,685,924 - 1,687,096 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365281,685,015 - 1,688,220 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNJ11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl241,757,356 - 41,765,555 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1241,756,637 - 41,760,340 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2244,815,173 - 44,817,370 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KCNJ11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1147,582,519 - 47,586,466 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl147,583,629 - 47,584,801 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666038145,013,121 - 145,016,726 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnj11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247669,013,225 - 9,014,397 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247669,012,166 - 9,015,269 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Kcnj11
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12153,408,959 - 153,412,626 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Kcnj11
65 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:125
Count of miRNA genes:100
Interacting mature miRNAs:108
Transcripts:ENSRNOT00000028685
Prediction methods:Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)192963855109494029Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1101228864146228864Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313083Bmd74Bone mineral density QTL 7440.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)191302413136302413Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1102359314153680016Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of, or within a discrete space in an open field apparatus (CMO:0001514)192683681137683681Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)192683681137683681Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)197582336142582336Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1101594089146594089Rat
61433Cia2Collagen induced arthritis QTL 25joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1100345976145345976Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)196717367160111531Rat

Markers in Region
PMC312732P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,592,815 - 96,593,315 (+)MAPPERmRatBN7.2
Rnor_6.01102,104,861 - 102,105,360NCBIRnor6.0
Rnor_5.01103,188,626 - 103,189,125UniSTSRnor5.0
RGSC_v3.4196,616,727 - 96,617,226UniSTSRGSC3.4
Celera190,843,838 - 90,844,337UniSTS
Cytogenetic Map1q22UniSTS
RH130776  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,591,617 - 96,591,832 (+)MAPPERmRatBN7.2
Rnor_6.01102,103,663 - 102,103,877NCBIRnor6.0
Rnor_5.01103,187,428 - 103,187,642UniSTSRnor5.0
RGSC_v3.4196,615,529 - 96,615,743UniSTSRGSC3.4
Celera190,842,640 - 90,842,854UniSTS
RH 3.4 Map1909.4UniSTS
Cytogenetic Map1q22UniSTS
BE113377  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2196,591,122 - 96,591,288 (+)MAPPERmRatBN7.2
Rnor_6.01102,103,168 - 102,103,333NCBIRnor6.0
Rnor_5.01103,186,933 - 103,187,098UniSTSRnor5.0
RGSC_v3.4196,615,034 - 96,615,199UniSTSRGSC3.4
Celera190,842,145 - 90,842,310UniSTS
RH 3.4 Map1908.9UniSTS
Cytogenetic Map1q22UniSTS


Genetic Models
This gene Kcnj11 is modified in the following models/strains:
SS-Kcnj11em5Mcwi     SS-Kcnj11em9Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
13 12 67 145 71 70 39 36 39 6 267 136 10 124 71 88 31 11 11

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589780 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092510 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB043638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC120807 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW527189 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF565039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D61687 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U44897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X97041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000028685   ⟹   ENSRNOP00000028685
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1105,727,570 - 105,731,169 (-)Ensembl
mRatBN7.2 Ensembl196,591,049 - 96,594,082 (-)Ensembl
Rnor_6.0 Ensembl1102,103,094 - 102,106,127 (-)Ensembl
RefSeq Acc Id: NM_031358   ⟹   NP_112648
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,727,473 - 105,730,506 (-)NCBI
mRatBN7.2196,591,049 - 96,594,082 (-)NCBI
Rnor_6.01102,103,094 - 102,106,127 (-)NCBI
Rnor_5.01103,186,859 - 103,190,535 (-)NCBI
RGSC_v3.4196,614,960 - 96,617,993 (-)RGD
Celera190,842,071 - 90,845,104 (-)RGD
Sequence:
RefSeq Acc Id: XM_008759421   ⟹   XP_008757643
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,727,473 - 105,731,167 (-)NCBI
mRatBN7.2196,591,048 - 96,594,574 (-)NCBI
Rnor_6.01102,103,093 - 102,107,134 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017589780   ⟹   XP_017445269
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,727,473 - 105,731,089 (-)NCBI
mRatBN7.2196,591,048 - 96,594,572 (-)NCBI
Rnor_6.01102,103,093 - 102,106,883 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017589782   ⟹   XP_017445271
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,727,473 - 105,730,927 (-)NCBI
mRatBN7.2196,591,049 - 96,594,503 (-)NCBI
Rnor_6.01102,103,093 - 102,106,539 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039092510   ⟹   XP_038948438
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,727,473 - 105,730,966 (-)NCBI
mRatBN7.2196,591,048 - 96,594,542 (-)NCBI
RefSeq Acc Id: XM_039092515   ⟹   XP_038948443
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,727,473 - 105,730,927 (-)NCBI
mRatBN7.2196,591,049 - 96,594,503 (-)NCBI
RefSeq Acc Id: XM_039092522   ⟹   XP_038948450
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,727,473 - 105,730,935 (-)NCBI
mRatBN7.2196,591,049 - 96,594,503 (-)NCBI
RefSeq Acc Id: NP_112648   ⟸   NM_031358
- UniProtKB: Q62906 (UniProtKB/Swiss-Prot),   Q9JM48 (UniProtKB/Swiss-Prot),   P70673 (UniProtKB/Swiss-Prot),   A6JBB1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008757643   ⟸   XM_008759421
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017445269   ⟸   XM_017589780
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017445271   ⟸   XM_017589782
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000028685   ⟸   ENSRNOT00000028685
RefSeq Acc Id: XP_038948438   ⟸   XM_039092510
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038948450   ⟸   XM_039092522
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038948443   ⟸   XM_039092515
- Peptide Label: isoform X3
Protein Domains
Inward rectifier potassium channel C-terminal   Potassium channel inwardly rectifying transmembrane

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70673-F1-model_v2 AlphaFold P70673 1-390 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69247 AgrOrtholog
BioCyc Gene G2FUF-59633 BioCyc
Ensembl Genes ENSRNOG00000021128 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000028685 ENTREZGENE
  ENSRNOT00000028685.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.287.70 UniProtKB/Swiss-Prot
  2.60.40.1400 UniProtKB/Swiss-Prot
InterPro Ig_E-set UniProtKB/Swiss-Prot
  IRK_C UniProtKB/Swiss-Prot
  K_chnl_inward-rec_Kir UniProtKB/Swiss-Prot
  K_chnl_inward-rec_Kir6.2 UniProtKB/Swiss-Prot
  K_chnl_inward-rec_Kir_cyto UniProtKB/Swiss-Prot
  Kir_TM UniProtKB/Swiss-Prot
KEGG Report rno:83535 UniProtKB/Swiss-Prot
NCBI Gene 83535 ENTREZGENE
PANTHER PTHR11767 UniProtKB/Swiss-Prot
  PTHR11767:SF44 UniProtKB/Swiss-Prot
Pfam IRK UniProtKB/Swiss-Prot
  IRK_C UniProtKB/Swiss-Prot
PharmGKB KCNJ11 RGD
PhenoGen Kcnj11 PhenoGen
PIRSF GIRK_kir UniProtKB/Swiss-Prot
PRINTS KIR62CHANNEL UniProtKB/Swiss-Prot
  KIRCHANNEL UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000021128 RatGTEx
Superfamily-SCOP SSF81296 UniProtKB/Swiss-Prot
  Voltage-gated potassium channels UniProtKB/Swiss-Prot
TIGR TC216683
UniProt A6JBB1 ENTREZGENE, UniProtKB/TrEMBL
  KCJ11_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q62906 ENTREZGENE
  Q9JM48 ENTREZGENE
UniProt Secondary Q62906 UniProtKB/Swiss-Prot
  Q9JM48 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Kcnj11  potassium inwardly rectifying channel, subfamily J, member 11      Symbol and Name status set to approved 1299863 APPROVED
2002-07-25 Kir6.2  potassium inwardly rectifying channel, subfamily J, member 11      gene retired, merged with Kcnj11 (RGD:69247) 61033 WITHDRAWN
2002-06-10 Kcnj11  potassium inwardly rectifying channel, subfamily J, member 11      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in vascular smooth muscle cells 724755