Abcc9_v1 (ATP binding cassette subfamily C member 9, variant 1) - Rat Genome Database

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Gene: Abcc9_v1 (ATP binding cassette subfamily C member 9, variant 1) Rattus norvegicus
Analyze
Symbol: Abcc9_v1
Name: ATP binding cassette subfamily C member 9, variant 1
RGD ID: 728331
Description: ENCODES an splice that exhibits ATPase-coupled monoatomic cation transmembrane transporter activity; identical protein binding; monoatomic cation channel activity; INVOLVED IN inorganic cation transmembrane transport; monoatomic cation transmembrane transport; potassium ion import across plasma membrane; ASSOCIATED WITH dilated cardiomyopathy (ortholog); FOUND IN inward rectifying potassium channel; sarcolemma
Type: splice  of Abcc9  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.


References

References - curated
# Reference Title Reference Citation
1. ABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gating. Bienengraeber M, etal., Nat Genet 2004 Apr;36(4):382-7. Epub 2004 Mar 21.
2. Conserved functional consequences of disease-associated mutations in the slide helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel. Cooper PE, etal., J Biol Chem. 2017 Oct 20;292(42):17387-17398. doi: 10.1074/jbc.M117.804971. Epub 2017 Aug 23.
3. Differential mechanisms of Cantú syndrome-associated gain of function mutations in the ABCC9 (SUR2) subunit of the KATP channel. Cooper PE, etal., J Gen Physiol. 2015 Dec;146(6):527-40. doi: 10.1085/jgp.201511495.
4. Chronic mild hypoxia protects heart-derived H9c2 cells against acute hypoxia/reoxygenation by regulating expression of the SUR2A subunit of the ATP-sensitive K+ channel. Crawford RM, etal., J Biol Chem. 2003 Aug 15;278(33):31444-55. Epub 2003 Jun 5.
5. Tetrameric structure of SUR2B revealed by electron microscopy of oriented single particles. Fotinou C, etal., FEBS J. 2013 Feb;280(4):1051-63. doi: 10.1111/febs.12097. Epub 2013 Jan 27.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channels. Inagaki N, etal., Neuron. 1996 May;16(5):1011-7.
8. Sulfonylurea receptors regulate the channel pore in ATP-sensitive potassium channels via an intersubunit salt bridge. Lodwick D, etal., Biochem J. 2014 Dec 15;464(3):343-54. doi: 10.1042/BJ20140273.
9. Detection of K(ATP) channels subunits in human term placental explants and evaluation of their implication in human placental lactogen (hPL) and human chorionic gonadotropin (hCG) release. Lybaert P, etal., Placenta. 2013 Jun;34(6):467-73. doi: 10.1016/j.placenta.2013.03.006. Epub 2013 Apr 13.
10. Proximal C-terminal domain of sulphonylurea receptor 2A interacts with pore-forming Kir6 subunits in KATP channels. Rainbow RD, etal., Biochem J. 2004 Apr 1;379(Pt 1):173-81.
11. Differential response of K(ATP) channels containing SUR2A or SUR2B subunits to nucleotides and pinacidil. Reimann F, etal., Mol Pharmacol. 2000 Dec;58(6):1318-25.
12. GOA pipeline RGD automated data pipeline
13. ATP-sensitive potassium channels mediate dilatation of basilar artery in response to intracellular acidification in vivo. Santa N, etal., Stroke 2003 May;34(5):1276-80.
14. Distribution of Kir6.0 and SUR2 ATP-sensitive potassium channel subunits in isolated ventricular myocytes. Singh H, etal., J Mol Cell Cardiol. 2003 May;35(5):445-59.

Genomics


Expression


Sequence

Nucleotide Sequences
GenBank Nucleotide D83598 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63563-F1-model_v2 AlphaFold Q63563 1-1545 view protein structure


Additional Information

Database Acc Id Source(s)
UniProt Q63563


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-12-14 Abcc9_v1  ATP-binding cassette, sub-family C (CFTR/MRP), member 9, variant 1      Symbol and Name status set to approved 1299863 APPROVED