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GENE - TERM ANNOTATION REPORT

RGD ID: 69247
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kcnj11
Name: potassium inwardly-rectifying channel, subfamily J, member 11
Acc ID: DOID:9744
Term: type 1 diabetes mellitus
Definition: A diabetes mellitus that is characterized by destruction of pancreatic beta cells resulting in absent or extremely low insulin production. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Diabetes "DO" "DO", http://en.wikipedia.org/wiki/Diabetes_mellitus_type_1 "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnj11 ISOKCNJ11 (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanismPMID:18025464
Kcnj11 ISOKCNJ11 (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Diabetes mellitus type 1 | ClinVar Annotator: match by term: Neonatal insulin-dependent diabetes mellitusPMID:12524280 PMID:15115830 PMID:15448106 PMID:15448107 PMID:15531505 PMID:15580558 PMID:15583126 PMID:15718250 PMID:15838686 PMID:16123337 PMID:16205880 PMID:16416420 PMID:16609879 PMID:16670688 PMID:16731837 PMID:16885550 PMID:17065345 PMID:17327377 PMID:17446535 PMID:17475937 PMID:17490422 PMID:17491708 PMID:17635943 PMID:17901525 PMID:18414213 PMID:18662362 PMID:19065048 PMID:20220270 PMID:20301620 PMID:20466780 PMID:22768671 PMID:24622368 PMID:25308342 PMID:25741868 PMID:26467025 PMID:26839896 PMID:26958039 PMID:27681997 PMID:28480665 PMID:28492532 PMID:29361385 PMID:32792356 PMID:32893419 PMID:33816067 PMID:33987715
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