KCNJ11 (potassium inwardly rectifying channel subfamily J member 11) - Rat Genome Database

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Pathways
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Gene: KCNJ11 (potassium inwardly rectifying channel subfamily J member 11) Pan paniscus
Analyze
Symbol: KCNJ11
Name: potassium inwardly rectifying channel subfamily J member 11
RGD ID: 11772177
Description: ENCODES a protein that exhibits ATP-activated inward rectifier potassium channel activity (ortholog); ATPase-coupled monoatomic cation transmembrane transporter activity (ortholog); heat shock protein binding (ortholog); INVOLVED IN action potential (ortholog); apoptotic process (ortholog); CAMKK-AMPK signaling cascade (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; altered insulin secretion pathway; ASSOCIATED WITH atopic dermatitis (ortholog); Congenital Hyperinsulinism (ortholog); Developmental Delay, Epilepsy, and Neonatal Diabetes (ortholog); FOUND IN acrosomal vesicle (ortholog); axolemma (ortholog); cell body fiber (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ATP-sensitive inward rectifier potassium channel 11; potassium inwardly-rectifying channel, subfamily J, member 11; potassium voltage-gated channel subfamily J member 11
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2919,706,414 - 19,723,055 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11119,679,358 - 19,683,468 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01117,440,522 - 17,444,075 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11117,125,885 - 17,129,579 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1117,127,557 - 17,128,729 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway   (ISO)
altered insulin secretion pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
forkhead class A signaling pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway   (ISO)
insulin secretion pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway   (ISO)
type 2 diabetes mellitus pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
KCNJ11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2919,706,414 - 19,723,055 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11119,679,358 - 19,683,468 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01117,440,522 - 17,444,075 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11117,125,885 - 17,129,579 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1117,127,557 - 17,128,729 (-)Ensemblpanpan1.1panPan2
KCNJ11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381117,385,248 - 17,389,346 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1117,365,172 - 17,389,331 (-)EnsemblGRCh38hg38GRCh38
GRCh371117,406,795 - 17,410,893 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361117,363,371 - 17,366,782 (-)NCBINCBI36Build 36hg18NCBI36
Build 341117,364,788 - 17,366,737NCBI
Celera1117,536,622 - 17,540,705 (-)NCBICelera
Cytogenetic Map11p15.1NCBI
HuRef1117,090,617 - 17,094,700 (-)NCBIHuRef
CHM1_11117,406,598 - 17,410,681 (-)NCBICHM1_1
T2T-CHM13v2.01117,482,848 - 17,486,946 (-)NCBIT2T-CHM13v2.0
Kcnj11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,746,545 - 45,750,215 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl745,743,377 - 45,750,188 (-)EnsemblGRCm39 Ensembl
GRCm38746,097,123 - 46,100,952 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl746,093,953 - 46,100,764 (-)EnsemblGRCm38mm10GRCm38
MGSCv37753,352,532 - 53,355,607 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36745,965,204 - 45,968,279 (-)NCBIMGSCv36mm8
Celera741,570,483 - 41,573,555 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.66NCBI
Kcnj11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,727,473 - 105,731,167 (-)NCBIGRCr8
mRatBN7.2196,591,048 - 96,594,574 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl196,591,049 - 96,594,082 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1101,977,177 - 101,980,211 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01110,449,162 - 110,452,195 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,739,531 - 103,742,564 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01102,103,093 - 102,107,134 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1102,103,094 - 102,106,127 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01103,186,859 - 103,190,535 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4196,614,960 - 96,617,993 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1196,693,070 - 96,696,104 (-)NCBI
Celera190,842,071 - 90,845,104 (-)NCBICelera
Cytogenetic Map1q22NCBI
Kcnj11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541432,210,545 - 32,211,717 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541432,209,426 - 32,212,424 (-)NCBIChiLan1.0ChiLan1.0
KCNJ11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12139,953,461 - 39,957,615 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2139,955,551 - 39,956,723 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2139,454,228 - 39,457,833 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02141,059,361 - 41,062,966 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2141,060,903 - 41,062,075 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12140,072,057 - 40,075,662 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02140,279,502 - 40,283,108 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02140,618,209 - 40,621,814 (-)NCBIUU_Cfam_GSD_1.0
Kcnj11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494745,651,254 - 45,654,240 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365281,685,924 - 1,687,096 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365281,685,015 - 1,688,220 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNJ11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl241,757,356 - 41,765,555 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1241,756,637 - 41,760,340 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2244,815,173 - 44,817,370 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KCNJ11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1147,582,519 - 47,586,466 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl147,583,629 - 47,584,801 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038145,013,121 - 145,016,726 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnj11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247669,013,225 - 9,014,397 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247669,012,166 - 9,015,269 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000018151   ⟹   ENSPPAP00000003923
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1117,127,557 - 17,128,729 (-)Ensembl
RefSeq Acc Id: XM_003818211   ⟹   XP_003818259
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2919,706,414 - 19,722,459 (-)NCBI
NHGRI_mPanPan11119,679,358 - 19,682,898 (-)NCBI
Mhudiblu_PPA_v01117,440,522 - 17,443,497 (-)NCBI
PanPan1.11117,125,885 - 17,129,542 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034932228   ⟹   XP_034788119
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2919,706,414 - 19,722,931 (-)NCBI
NHGRI_mPanPan11119,679,358 - 19,683,375 (-)NCBI
Mhudiblu_PPA_v01117,440,522 - 17,443,969 (-)NCBI
RefSeq Acc Id: XM_034932229   ⟹   XP_034788120
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2919,706,414 - 19,723,055 (-)NCBI
NHGRI_mPanPan11119,679,358 - 19,683,468 (-)NCBI
Mhudiblu_PPA_v01117,440,522 - 17,444,075 (-)NCBI
RefSeq Acc Id: XM_057299113   ⟹   XP_057155096
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2919,706,414 - 19,722,782 (-)NCBI
NHGRI_mPanPan11119,679,358 - 19,683,222 (-)NCBI
Protein Sequences
Protein RefSeqs XP_003818259 (Get FASTA)   NCBI Sequence Viewer  
  XP_034788119 (Get FASTA)   NCBI Sequence Viewer  
  XP_034788120 (Get FASTA)   NCBI Sequence Viewer  
  XP_057155096 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000003923.1
Reference Protein Sequences
RefSeq Acc Id: XP_003818259   ⟸   XM_003818211
- Peptide Label: isoform X1
- UniProtKB: A0A2R8ZFZ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034788120   ⟸   XM_034932229
- Peptide Label: isoform X2
RefSeq Acc Id: XP_034788119   ⟸   XM_034932228
- Peptide Label: isoform X2
RefSeq Acc Id: ENSPPAP00000003923   ⟸   ENSPPAT00000018151
RefSeq Acc Id: XP_057155096   ⟸   XM_057299113
- Peptide Label: isoform X2
Protein Domains
Inward rectifier potassium channel C-terminal   Potassium channel inwardly rectifying transmembrane


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000016577 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000018151.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
  2.60.40.1400 UniProtKB/TrEMBL
InterPro Ig_E-set UniProtKB/TrEMBL
  IRK_C UniProtKB/TrEMBL
  K_chnl_inward-rec_Kir UniProtKB/TrEMBL
  K_chnl_inward-rec_Kir6.2 UniProtKB/TrEMBL
  K_chnl_inward-rec_Kir_cyto UniProtKB/TrEMBL
  Kir_TM UniProtKB/TrEMBL
KEGG Report pps:100980303 UniProtKB/TrEMBL
NCBI Gene KCNJ11 ENTREZGENE
PANTHER PTHR11767 UniProtKB/TrEMBL
  PTHR11767:SF44 UniProtKB/TrEMBL
Pfam IRK UniProtKB/TrEMBL
  IRK_C UniProtKB/TrEMBL
PIRSF GIRK_kir UniProtKB/TrEMBL
PRINTS KIR62CHANNEL UniProtKB/TrEMBL
  KIRCHANNEL UniProtKB/TrEMBL
Superfamily-SCOP SSF81296 UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt A0A2R8ZFZ9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-07-23 KCNJ11  potassium inwardly rectifying channel subfamily J member 11  KCNJ11  potassium voltage-gated channel subfamily J member 11  Symbol and/or name change 5135510 APPROVED