Nos1 (nitric oxide synthase 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Nos1 (nitric oxide synthase 1) Rattus norvegicus
Analyze
Symbol: Nos1
Name: nitric oxide synthase 1
RGD ID: 3184
Description: Enables several functions, including ATPase binding activity; nucleotide binding activity; and transition metal ion binding activity. Involved in several processes, including behavioral response to cocaine; blood vessel diameter maintenance; and regulation of monoatomic cation transmembrane transport. Located in several cellular components, including azurophil granule; nuclear membrane; and sarcolemma. Part of protein-containing complex. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Used to study several diseases, including acute necrotizing pancreatitis; brain ischemia (multiple); end stage renal disease; impotence; and portal hypertension. Biomarker of several diseases, including brain disease (multiple); cardiomyopathy (multiple); hypertension (multiple); kidney failure (multiple); and retinal disease (multiple). Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; asthma; and cystic fibrosis. Orthologous to human NOS1 (nitric oxide synthase 1); PARTICIPATES IN AGAT deficiency pathway; arginine and proline metabolic pathway; guanidinoacetate methyltransferase deficiency pathway; INTERACTS WITH (+)-pilocarpine; (S)-colchicine; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: bNOS; constitutive NOS; N-NOS; NC-NOS; neuronal NOS; nitric oxidase synthase; nitric oxide synthase 1 (neuronal); nitric oxide synthase 1, neuronal; nitric oxide synthase, brain; nNOS; NOS type I; peptidyl-cysteine S-nitrosylase NOS1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Nos1m1Mcwi
Genetic Models: BN-Nos1m1Mcwi
Is Marker For: Strains:   SD
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81244,276,011 - 44,456,371 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1244,287,614 - 44,371,837 (-)EnsemblGRCr8
mRatBN7.21238,615,111 - 38,795,492 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1238,626,714 - 38,710,945 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1239,802,061 - 39,886,285 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01240,415,854 - 40,500,100 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01239,468,822 - 39,553,063 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01244,214,949 - 44,405,530 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1244,213,943 - 44,520,341 (-)Ensemblrn6Rnor6.0
Rnor_5.01246,049,288 - 46,209,569 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41239,812,500 - 39,869,484 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1240,283,655 - 40,368,674 (-)NCBICelera
RGSC_v3.11239,675,108 - 39,732,872 (-)NCBI
RH 3.4 Map12718.8RGD
RH 3.4 Map12717.0RGD
Cytogenetic Map12q16NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
achalasia  (ISS)
acute kidney failure  (IEP)
acute necrotizing pancreatitis  (IDA)
alcoholic cardiomyopathy  (IEP)
allergic asthma  (ISO)
Alzheimer's disease  (ISO)
amphetamine abuse  (ISO)
arteriosclerosis  (ISO)
asthma  (ISO)
autism spectrum disorder  (ISO)
brain ischemia  (IEP,IMP)
Bronchial Hyperreactivity  (ISO)
Carbon Monoxide Poisoning  (IMP)
Cardiomegaly  (IEP)
cardiomyopathy  (IEP)
cerebellar disease  (ISO)
chronic obstructive pulmonary disease  (ISO)
congestive heart failure  (IEP)
cystic fibrosis  (ISO)
Dehydration  (IEP)
depressive disorder  (IDA,ISO)
Diabetic Nephropathies  (IDA,IMP)
diabetic retinopathy  (IEP)
disease of mental health  (ISO)
Duchenne muscular dystrophy  (ISO)
End Stage Liver Disease  (ISO)
end stage renal disease  (IDA,IEP)
Experimental Diabetes Mellitus  (IDA)
Experimental Radiation Injuries  (ISO)
fetal alcohol spectrum disorder  (ISO)
Fetal Growth Retardation  (IEP)
Fetal Hypoxia  (IEP)
Fever  (ISO)
Heat Stroke  (IEP)
hepatic encephalopathy  (IEP,ISO)
Human Influenza  (ISO)
Hyperalgesia  (IEP,ISO)
hypertension  (IDA,IEP,IMP)
hypertrophic pyloric stenosis  (ISS)
Hypoxia  (ISO)
impotence  (IDA,IEP)
Infantile Hypertrophic Pyloric Stenosis 1  (ISO)
intestinal perforation  (ISO)
intracranial aneurysm  (ISO)
major depressive disorder  (IEP)
Memory Disorders  (IMP)
morphine dependence  (ISO)
motor neuron disease  (ISO)
nephrotic syndrome  (IEP)
Nerve Degeneration  (ISO)
nervous system disease  (ISO)
Nervous System Trauma  (ISO)
Neuralgia  (IDA)
Neurobehavioral Manifestations  (ISO)
obesity  (IEP)
Parkinson's disease  (ISO)
Parkinsonism  (IEP)
portal hypertension  (IDA)
Prehypertension  (IEP)
Prenatal Exposure Delayed Effects  (IEP)
renovascular hypertension  (IEP)
Reperfusion Injury  (IMP)
retinopathy of prematurity  (IEP)
Right Ventricular Hypertrophy  (IDA)
schizophrenia  (IMP,ISO)
Sepsis  (IMP)
Spinal Cord Injuries  (IEP,IMP)
status epilepticus  (ISO)
stroke  (IMP)
temporal lobe epilepsy  (IEP)
transient cerebral ischemia  (IDA,IEP)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (IEP)
urethral obstruction  (IEP)
Urination Disorders  (ISO)
Ventricular Remodeling  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(3,4-dihydroxyphenyl)acetic acid  (ISO)
(S)-amphetamine  (ISO)
(S)-colchicine  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrotoluene  (EXP)
2-(4-iodo-2,5-dimethoxyphenyl)-1-methylethylamine  (EXP)
2-palmitoylglycerol  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (EXP,ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-BROMO-7-NITROINDAZOLE  (ISO)
4-hydroxy-TEMPO  (EXP)
5,5-dimethyl-1-pyrroline N-oxide  (ISO)
6-propyl-2-thiouracil  (EXP)
7,8-diacetoxy-4-methylcoumarin  (ISO)
7-nitroindazole  (EXP,ISO)
8'-apo-beta,psi-caroten-8'-al  (ISO)
acetamide  (EXP)
acrylamide  (EXP,ISO)
ADP-D-ribose  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alloxan  (ISO)
alpha-Zearalanol  (EXP)
aluminium sulfate (anhydrous)  (EXP)
aminoguanidine  (EXP)
ammonium chloride  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (EXP,ISO)
beta-carotene  (ISO)
betulinic acid  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
Brodifacoum  (EXP)
buspirone  (EXP)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
calcium atom  (EXP)
calcium dichloride  (EXP)
calcium(0)  (EXP)
Candesartan cilexetil  (EXP)
cantharidin  (ISO)
capsaicin  (EXP,ISO)
carvacrol  (EXP)
CGP 52608  (ISO)
chaetocin  (EXP)
chlorpyrifos  (EXP,ISO)
cisplatin  (EXP)
cobalt dichloride  (EXP)
cocaine  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
curcumin  (EXP,ISO)
cyclophosphamide  (EXP)
cypermethrin  (ISO)
D-glucose  (ISO)
DDE  (EXP)
decabromodiphenyl ether  (ISO)
Decursin  (ISO)
dexamethasone  (EXP,ISO)
Diallyl sulfide  (EXP)
dibutyl phthalate  (EXP)
dibutylstannane  (EXP)
dichlorine  (EXP)
dichloroacetic acid  (ISO)
dicyclanil  (ISO)
dimemorfan  (EXP)
diminazene diaceturate  (EXP)
dioxygen  (EXP)
disodium selenite  (ISO)
dizocilpine maleate  (ISO)
dobutamine  (ISO)
dopamine  (ISO)
dorsomorphin  (ISO)
edaravone  (EXP)
endosulfan  (EXP)
enoxacin  (ISO)
entinostat  (ISO)
enzyme inhibitor  (EXP)
ethanol  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
ethylparaben  (ISO)
fenbufen  (ISO)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (EXP)
fulvestrant  (ISO)
gentamycin  (ISO)
glucose  (ISO)
GW 4064  (ISO)
hexachlorobenzene  (ISO)
hexacosan-1-ol  (EXP)
homovanillic acid  (ISO)
hydralazine  (EXP)
hydrogen peroxide  (EXP,ISO)
ibuprofen  (ISO)
icariin  (EXP)
ifosfamide  (EXP)
indometacin  (ISO)
isoprenaline  (EXP)
kainic acid  (EXP)
KT 5720  (EXP)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
lead(II) chloride  (EXP,ISO)
leflunomide  (EXP)
linsidomine  (EXP)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium chloride  (EXP)
lithium hydride  (EXP)
loperamide  (ISO)
losartan  (EXP)
lycopene  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (ISO)
manganese(II) sulfate  (EXP)
mastoparan  (EXP)
Mazindol  (ISO)
melatonin  (EXP)
melittin  (EXP)
mephedrone  (EXP)
mercury dichloride  (EXP)
metformin  (ISO)
methamphetamine  (ISO)
methoctramine tetrahydrochloride  (EXP)
methotrexate  (EXP)
methoxychlor  (EXP)
metoprolol  (EXP)
mevinphos  (EXP)
milrinone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morin  (EXP)
morphine  (EXP,ISO)
mosapride citrate dihydrate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-ethyl-N-nitrosourea  (EXP)
N-methyl-4-phenylpyridinium  (EXP)
N-methyl-D-aspartic acid  (ISO)
naloxone  (ISO)
Neferine  (EXP)
nickel atom  (ISO)
nitric oxide  (EXP,ISO)
nitroglycerin  (EXP)
nitroprusside  (ISO)
O-acetyl-L-carnitine  (EXP)
ouabain  (EXP)
oxidopamine  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
palytoxin  (ISO)
paracetamol  (EXP)
paraquat  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
phenol  (EXP)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
puerarin  (ISO)
quercetin  (EXP,ISO)
quinolinic acid  (EXP)
ramipril  (EXP)
reactive nitrogen species  (EXP)
reactive oxygen species  (EXP)
reserpine  (EXP)
resveratrol  (EXP,ISO)
rofecoxib  (ISO)
S-methyl-L-thiocitrulline  (EXP,ISO)
SB 431542  (ISO)
selenic acid  (ISO)
selenomethionine  (ISO)
serpentine asbestos  (ISO)
sildenafil citrate  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sirtinol  (EXP)
sodium arsenite  (EXP,ISO)
sodium atom  (EXP)
sodium chloride  (EXP)
sodium sulfite  (ISO)
streptozocin  (EXP,ISO)
sulfur dioxide  (EXP)
sumatriptan  (EXP)
tacrine  (EXP)
tacrolimus hydrate  (EXP)
tamoxifen  (EXP)
testosterone  (ISO)
tetrachloromethane  (EXP)
tetramethylpyrazine  (EXP)
thioacetamide  (EXP)
thymoquinone  (EXP)
thyroxine  (EXP)
tributylstannane  (EXP)
triclosan  (ISO)
triphenylstannane  (EXP)
triptonide  (ISO)
Tropicamide  (EXP)
trovafloxacin  (ISO)
U-73122  (EXP)
udenafil  (EXP)
valproic acid  (EXP)
valsartan  (EXP)
vincristine  (ISO)
zileuton  (ISO)
zinc dichloride  (EXP)
zinc protoporphyrin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
behavioral response to cocaine  (IMP)
cell communication  (IEA)
cellular response to epinephrine stimulus  (IMP)
cellular response to growth factor stimulus  (IEA,ISO)
cellular response to mechanical stimulus  (IMP)
establishment of protein localization  (IDA)
female pregnancy  (IEP)
L-arginine catabolic process  (IBA,IDA)
multicellular organismal response to stress  (IEA,ISO)
negative regulation of apoptotic process  (IMP)
negative regulation of blood pressure  (IBA,IMP)
negative regulation of calcium ion transport  (ISO)
negative regulation of cell population proliferation  (IMP)
negative regulation of cytosolic calcium ion concentration  (IMP)
negative regulation of hepatic stellate cell contraction  (IDA)
negative regulation of hydrolase activity  (ISO)
negative regulation of insulin secretion  (IMP)
negative regulation of iron ion transmembrane transport  (IMP)
negative regulation of monoatomic ion transport  (IEA)
negative regulation of neuron apoptotic process  (IMP)
negative regulation of potassium ion transport  (ISO)
negative regulation of serotonin uptake  (IEA,ISO)
negative regulation of vasoconstriction  (IMP)
nitric oxide biosynthetic process  (IBA,IDA,IEA,ISO)
nitric oxide mediated signal transduction  (IBA)
nitric oxide metabolic process  (IEP)
nitric oxide-cGMP-mediated signaling  (IMP)
peptidyl-cysteine S-nitrosylation  (ISO)
positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway  (IMP)
positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway  (IEA,ISO)
positive regulation of cellular process  (IMP)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of G protein-coupled receptor signaling pathway  (IEA)
positive regulation of long-term synaptic potentiation  (IMP)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of sodium ion transmembrane transport  (IMP)
positive regulation of the force of heart contraction  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
regulation of blood circulation  (IEA)
regulation of neurogenesis  (IEA,ISO)
regulation of postsynaptic membrane potential  (IEA,ISO)
regulation of sodium ion transport  (IEA,ISO)
response to activity  (IEA,IEP)
response to decreased oxygen levels  (IEA)
response to estrogen  (IDA)
response to ethanol  (IEP)
response to heat  (IEA,ISO)
response to hormone  (IBA)
response to hypoxia  (IEA,IEP,ISO)
response to lead ion  (IEA,IEP)
response to lipopolysaccharide  (IBA,IEA,IEP)
response to mechanical stimulus  (IEA)
response to nicotine  (IEP)
response to nitric oxide  (IEP)
response to nutrient levels  (IEA,IEP)
response to peptide hormone  (IMP)
response to vitamin B3  (IEP)
response to vitamin E  (IEP)
signaling  (IEA)
striated muscle contraction  (ISO)
synaptic signaling by nitric oxide  (IEA,ISO)
system process  (IEA)
vasodilation  (IEA,IMP,ISO)
xenobiotic catabolic process  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Altered Contractile Response due to Increased beta3-Adrenoceptor Stimulation in Diabetic Cardiomyopathy: The Role of Nitric Oxide Synthase 1-derived Nitric Oxide. Amour J, etal., Anesthesiology. 2007 Sep;107(3):452-460.
2. Complementary inhibition of cerebral aneurysm formation by eNOS and nNOS. Aoki T, etal., Lab Invest. 2011 Apr;91(4):619-26. Epub 2011 Feb 14.
3. Renoprotective effect of pioglitazone by the prevention of glomerular hyperfiltration through the possible restoration of altered macula densa signaling in rats with type 2 diabetic nephropathy. Asakura J, etal., Nephron Exp Nephrol. 2012;122(3-4):83-94. doi: 10.1159/000348661. Epub 2013 Mar 29.
4. Neuronal nitric oxide synthase protects the pancreatic beta cell from glucolipotoxicity-induced endoplasmic reticulum stress and apoptosis. Bachar E, etal., Diabetologia. 2010 Oct;53(10):2177-87. Epub 2010 Jul 2.
5. Nitric oxide synthases and protein oxidation in the quadriceps femoris of patients with chronic obstructive pulmonary disease. Barreiro E, etal., Am J Respir Cell Mol Biol. 2003 Dec;29(6):771-8. Epub 2003 Jun 19.
6. Nitrergic dendrites in the superficial layers of the rat superior colliculus: retinal afferents and alternatively spliced isoforms in normal and deafferented animals. Batista CM, etal., J Neurosci Res 2003 Feb 1;71(3):455-61.
7. Reduced neuronal nitric oxide synthase (NOS1) antigen in sacral motor neurones in motor neurone disease. Baxter RG, etal., Acta Neuropathol. 2002 Oct;104(4):391-7. Epub 2002 Jun 26.
8. Role of myocardial neuronal nitric oxide synthase-derived nitric oxide in beta-adrenergic hyporesponsiveness after myocardial infarction-induced heart failure in rat. Bendall JK, etal., Circulation. 2004 Oct 19;110(16):2368-75. Epub 2004 Oct 4.
9. Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase. Bredt DS, etal., Nature. 1991 Jun 27;351(6329):714-8. doi: 10.1038/351714a0.
10. Nitric oxide synthase isoenzyme expression and activity in peripheral lung tissue of patients with chronic obstructive pulmonary disease. Brindicci C, etal., Am J Respir Crit Care Med. 2010 Jan 1;181(1):21-30. Epub 2009 Sep 24.
11. Synaptic localization of nitric oxide synthase and soluble guanylyl cyclase in the hippocampus. Burette A, etal., J Neurosci. 2002 Oct 15;22(20):8961-70.
12. Downregulation of nNOS and synthesis of PGs associated with endotoxin-induced delay in gastric emptying. Calatayud S, etal., Am J Physiol Gastrointest Liver Physiol 2002 Dec;283(6):G1360-7.
13. Nitrous oxide discretely up-regulates nNOS and p53 in neonatal rat brain. Cattano D, etal., Minerva Anestesiol. 2010 Jun;76(6):420-4. Epub 2010 Apr 12.
14. Inhibition of neuronal nitric oxide synthase causes attenuation of cerebrovascular dysfunction in experimental heatstroke. Cheng BC, etal., Neuropharmacology. 2007 Feb;52(2):297-305. Epub 2006 Sep 6.
15. Calmodulin activates electron transfer through neuronal nitric-oxide synthase reductase domain by releasing an NADPH-dependent conformational lock. Craig DH, etal., J Biol Chem 2002 Sep 13;277(37):33987-94.
16. The anti-cancer agent SU4312 unexpectedly protects against MPP(+) -induced neurotoxicity via selective and direct inhibition of neuronal NOS. Cui W, etal., Br J Pharmacol. 2013 Mar;168(5):1201-14. doi: 10.1111/bph.12004.
17. Elevated expression of CAPON and neuronal nitric oxide synthase in the sciatic nerve of rats following constriction injury. Cui Z, etal., Vet J. 2011 Mar;187(3):374-80. Epub 2010 Mar 3.
18. Renal redox response to normal pregnancy in the rat. Cunningham MW Jr, etal., Am J Physiol Regul Integr Comp Physiol. 2013 Mar 15;304(6):R443-9. doi: 10.1152/ajpregu.00496.2012. Epub 2013 Jan 2.
19. Coupling of neuronal nitric oxide synthase to NMDA receptors via postsynaptic density-95 depends on estrogen and contributes to the central control of adult female reproduction. d'Anglemont de Tassigny X, etal., J Neurosci. 2007 Jun 6;27(23):6103-14.
20. Spinal cord transection significantly influences nNOS-IR in neuronal circuitry that underlies the tail-flick reflex activity. Davidova A, etal., Cell Mol Neurobiol. 2009 Sep;29(6-7):879-86. Epub 2009 Mar 17.
21. Locus for the inducible, but not a constitutive, nitric oxide synthase cosegregates with blood pressure in the Dahl salt-sensitive rat. Deng AY and Rapp JP, J Clin Invest 1995 May;95(5):2170-7
22. Cyclic stretch stimulates nitric oxide synthase-1-dependent peroxynitrite formation by neonatal rat pulmonary artery smooth muscle. Dick AS, etal., Free Radic Biol Med. 2013 Apr 22;61C:310-319. doi: 10.1016/j.freeradbiomed.2013.04.027.
23. [Effects of electroacupuncture on the expressions of neuroal nitric oxide synthase and astrocyte in dentate gyrus of rats with Parkinson's disease]. Ding YX, etal., Zhongguo Zhen Jiu. 2013 Jun;33(6):533-7.
24. Reduction of neuronal and inducible nitric oxide synthase gene expression in patients with cystic fibrosis. Dotsch J, etal., Eur Arch Otorhinolaryngol. 2002 Apr;259(4):222-6.
25. Plasma membrane calcium ATPase 4b inhibits nitric oxide generation through calcium-induced dynamic interaction with neuronal nitric oxide synthase. Duan W, etal., Protein Cell. 2013 Apr;4(4):286-98. doi: 10.1007/s13238-013-2116-z. Epub 2013 Apr 3.
26. Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON. Fang M, etal., Neuron 2000 Oct;28(1):183-93.
27. Human influenza viral infection in utero increases nNOS expression in hippocampi of neonatal mice. Fatemi SH, etal., Synapse. 1998 May;29(1):84-8.
28. Differential expression of nNOS mRNA and protein in the nucleus tractus solitarii of young and aged Wistar-Kyoto and spontaneously hypertensive rats. Ferrari MF and Fior-Chadi DR, J Hypertens. 2005 Sep;23(9):1683-90.
29. Hypothyroid phenotype is contributed by mitochondrial complex I inactivation due to translocated neuronal nitric-oxide synthase. Franco MC, etal., J Biol Chem. 2006 Feb 24;281(8):4779-86. Epub 2005 Dec 16.
30. Involvement of nNOS/NO/sGC/cGMP signaling pathway in cocaine sensitization and in the associated hippocampal alterations: does phosphodiesterase 5 inhibition help to drug vulnerability? Gabach LA, etal., Psychopharmacology (Berl). 2013 Sep;229(1):41-50. doi: 10.1007/s00213-013-3084-y. Epub 2013 Apr 12.
31. Association of a NOS1 promoter repeat with Alzheimer's disease. Galimberti D, etal., Neurobiol Aging. 2008 Sep;29(9):1359-65. doi: 10.1016/j.neurobiolaging.2007.03.003. Epub 2007 Apr 6.
32. Diabetes induces sex-dependent changes in neuronal nitric oxide synthase dimerization and function in the rat gastric antrum. Gangula PR, etal., Am J Physiol Gastrointest Liver Physiol. 2007 Mar;292(3):G725-33.
33. Y-27632 improves the erectile dysfunction with ageing in SD rats through adjusting the imbalance between nNo and the Rho-kinase pathways. Gao BH, etal., Andrologia. 2007 Aug;39(4):146-50.
34. Variants of NOS1, NOS2, and NOS3 genes in asthmatics. Gao PS, etal., Biochem Biophys Res Commun. 2000 Jan 27;267(3):761-3.
35. Nitric oxide synthase and nitric oxide alterations in chronically stressed rats: a model for nitric oxide in major depressive disorder. Gao SF, etal., Psychoneuroendocrinology. 2014 Sep;47:136-40. doi: 10.1016/j.psyneuen.2014.05.009. Epub 2014 May 22.
36. Sustained gonadotropin-releasing hormone stimulation mobilizes the cAMP/PKA pathway to induce nitric oxide synthase type 1 expression in rat pituitary cells in vitro and in vivo at proestrus. Garrel G, etal., Biol Reprod. 2010 Jun;82(6):1170-9. Epub 2010 Feb 24.
37. Overexpression of neutrophil neuronal nitric oxide synthase in Parkinson's disease. Gatto EM, etal., Nitric Oxide. 2000 Oct;4(5):534-9.
38. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
39. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
40. Caveolin-3 and nitric oxide synthase I in healthy and diseased skeletal muscle. Gossrau R, Acta Histochem. 1998 Feb;100(1):99-112. doi: 10.1016/S0065-1281(98)80009-3.
41. A neuronal NO synthase (NOS1) gene polymorphism is associated with asthma. Grasemann H, etal., Biochem Biophys Res Commun. 2000 Jun 7;272(2):391-4.
42. Nasal nitric oxide levels in cystic fibrosis patients are associated with a neuronal NO synthase (NOS1) gene polymorphism. Grasemann H, etal., Nitric Oxide. 2002 Mar;6(2):236-41.
43. Expression of nitric oxide synthase isoforms in hypothalamo-pituitary-adrenal axis during the development of spontaneous hypertension in rats. Hauser W, etal., Brain Res Mol Brain Res. 2005 Aug 18;138(2):198-204.
44. Role of bound zinc in dimer stabilization but not enzyme activity of neuronal nitric-oxide synthase. Hemmens B, etal., J Biol Chem. 2000 Nov 17;275(46):35786-91. doi: 10.1074/jbc.M005976200.
45. Noradrenergic depletion potentiates beta -amyloid-induced cortical inflammation: implications for Alzheimer's disease. Heneka MT, etal., J Neurosci 2002 Apr 1;22(7):2434-42.
46. Maternal Exposure to Bisphenol A Combined with High-Fat Diet-Induced Programmed Hypertension in Adult Male Rat Offspring: Effects of Resveratrol. Hsu CN, etal., Int J Mol Sci. 2019 Sep 6;20(18):4382. doi: 10.3390/ijms20184382.
47. Aminoguanidine attenuates hypertension, whereas 7-nitroindazole exacerbates kidney damage in spontaneously hypertensive rats: the role of nitric oxide. Huang CF, etal., Eur J Pharmacol. 2013 Jan 15;699(1-3):233-40. doi: 10.1016/j.ejphar.2012.11.034. Epub 2012 Nov 28.
48. Chronic intermittent hypoxia modulates nNOS mRNA and protein expression in the rat hypothalamus. Huang J, etal., Respir Physiol Neurobiol. 2007 Aug 15;158(1):30-8. Epub 2007 Mar 18.
49. Hydrogen supplemented air inhalation reduces changes of prooxidant enzyme and gap junction protein levels after transient global cerebral ischemia in the rat hippocampus. Hugyecz M, etal., Brain Res. 2011 Aug 2;1404:31-8. Epub 2011 Jun 12.
50. Dynamin activates NO production in rat renal inner medullary collecting ducts via protein-protein interaction with NOS1. Hyndman KA, etal., Am J Physiol Renal Physiol. 2011 Apr 13.
51. CAPON: a protein associated with neuronal nitric oxide synthase that regulates its interactions with PSD95. Jaffrey SR, etal., Neuron 1998 Jan;20(1):115-24.
52. Neuronal nitric-oxide synthase localization mediated by a ternary complex with synapsin and CAPON. Jaffrey SR, etal., Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3199-204. Epub 2002 Feb 26.
53. Role of neuronal nitric oxide in the inhibition of sympathetic vasoconstriction in resting and contracting skeletal muscle of healthy rats. Jendzjowsky NG and Delorey DS, J Appl Physiol. 2013 Jul;115(1):97-106. doi: 10.1152/japplphysiol.00250.2013. Epub 2013 May 2.
54. Combined therapeutic effect of udenafil and adipose-derived stem cell (ADSC)/brain-derived neurotrophic factor (BDNF)-membrane system in a rat model of cavernous nerve injury. Jeong HH, etal., Urology. 2013 May;81(5):1108.e7-14. doi: 10.1016/j.urology.2013.01.022. Epub 2013 Mar 22.
55. Effect of Mas-related gene (Mrg) receptors on hyperalgesia in rats with CFA-induced inflammation via direct and indirect mechanisms. Jiang J, etal., Br J Pharmacol. 2013 Aug 2. doi: 10.1111/bph.12326.
56. Early and sharp nitric oxide production and anoxic depolarization in the rat hippocampus during transient forebrain ischemia. Jiang MH and Hada J, Eur J Pharmacol. 2007 Jul 12;567(1-2):83-8. Epub 2007 Mar 24.
57. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
58. Hippocampal neuronal nitric oxide synthase (nNOS) is regulated by nicotine and stress in female but not in male rats. Keser A, etal., Brain Res. 2011 Jan 12;1368:134-42. Epub 2010 Nov 2.
59. Triamcinolone acetonide prevents enhancement of hypoxia-induced neuronal and inducible nitric oxide synthases in the retinas of rats with oxygen-induced retinopathy. Kim SJ, etal., Korean J Ophthalmol. 2012 Dec;26(6):455-61. doi: 10.3341/kjo.2012.26.6.455. Epub 2012 Nov 12.
60. Effect of detrusor overactivity on the expression of aquaporins and nitric oxide synthase in rat urinary bladder following bladder outlet obstruction. Kim SO, etal., Can Urol Assoc J. 2013 May-Jun;7(5-6):E268-74. doi: 10.5489/cuaj.993.
61. Enhanced expression of neuronal nitric oxide synthase and phospholipase C-gamma1 in regenerating murine neuronal cells by pulsed electromagnetic field. Kim SS, etal., Exp Mol Med 2002 Mar 31;34(1):53-9.
62. Plasticity of basal ganglia neurocircuitries following perinatal asphyxia: effect of nicotinamide. Klawitter V, etal., Exp Brain Res. 2007 Jun;180(1):139-52. Epub 2007 Feb 20.
63. Nitric oxide in skeletal muscle. Kobzik L, etal., Nature. 1994 Dec 8;372(6506):546-8.
64. Role of neuronal nitric oxide synthase (NOS1) in the pathogenesis of renal hemodynamic changes in diabetes. Komers R, etal., Am J Physiol Renal Physiol. 2000 Sep;279(3):F573-83. doi: 10.1152/ajprenal.2000.279.3.F573.
65. Role of Asp1393 in catalysis, flavin reduction, NADP(H) binding, FAD thermodynamics, and regulation of the nNOS flavoprotein. Konas DW, etal., Biochemistry. 2006 Oct 17;45(41):12596-609.
66. Chronic ethanol exposure impairs neuronal nitric oxide synthase in the rat intestine. Krecsmarik M, etal., Alcohol Clin Exp Res. 2006 Jun;30(6):967-73.
67. Atheroprotective effects of neuronal nitric oxide synthase in apolipoprotein e knockout mice. Kuhlencordt PJ, etal., Arterioscler Thromb Vasc Biol. 2006 Jul;26(7):1539-44. Epub 2006 Apr 20.
68. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
69. A neuronal isoform of nitric oxide synthase expressed in pancreatic beta-cells controls insulin secretion. Lajoix AD, etal., Diabetes. 2001 Jun;50(6):1311-23.
70. Protein inhibitor of neuronal nitric oxide synthase (PIN) is a new regulator of glucose-induced insulin secretion. Lajoix AD, etal., Diabetes. 2006 Dec;55(12):3279-88.
71. Cellulose membrane supported peptide arrays for deciphering protein-protein interaction sites: the case of PIN, a protein with multiple natural partners. Lajoix AD, etal., Mol Divers. 2004;8(3):281-90.
72. Neuronal nitric oxide synthase (bNOS) messenger RNA and protein expression in developing rat brainstem nuclei. Leimert M and Blottner D, Neurosci Lett. 2003 May 15;342(1-2):57-60.
73. Targeted neuronal nitric oxide synthase transgene delivery into stellate neurons reverses impaired intracellular calcium transients in prehypertensive rats. Li D, etal., Hypertension. 2013 Jan;61(1):202-7. doi: 10.1161/HYPERTENSIONAHA.111.00105. Epub 2012 Nov 19.
74. The nNOS-p38MAPK pathway is mediated by NOS1AP during neuronal death. Li LL, etal., J Neurosci. 2013 May 8;33(19):8185-201. doi: 10.1523/JNEUROSCI.4578-12.2013.
75. Effect of hereditary obesity on renal expressions of NO synthase, caveolin-1, AKt, guanylate cyclase, and calmodulin. Li Z, etal., Kidney Int. 2005 Dec;68(6):2766-72.
76. [Antidepressant effect of microinjection of neuropeptide Y into the hippocampus is mediated by decreased expression of nitric oxide synthase]. Lian T and An SC, Sheng Li Xue Bao. 2010 Jun 25;62(3):237-46.
77. Evaluation of the Effect of Different Doses of Low Energy Shock Wave Therapy on the Erectile Function of Streptozotocin (STZ)-Induced Diabetic Rats. Liu J, etal., Int J Mol Sci. 2013 May 21;14(5):10661-73. doi: 10.3390/ijms140510661.
78. The dynamic detection of NO during stroke and reperfusion in vivo. Liu K, etal., Brain Inj. 2009 May;23(5):450-8.
79. Inhibition of neuronal nitric oxide synthase antagonizes morphine antinociceptive tolerance by decreasing activation of p38 MAPK in the spinal microglia. Liu W, etal., Neurosci Lett. 2006 Dec 27;410(3):174-7. Epub 2006 Nov 13.
80. Involvement of Nitric Oxide in Spatial Memory Deficits in Status Epilepticus Rats. Liu ZW, etal., Neurochem Res. 2007 Jun 5;.
81. 5'-flanking region polymorphism of the neuronal nitric oxide synthase gene with Parkinson's disease in Taiwan. Lo HS, etal., J Neurol Sci 2002 Feb 15;194(1):11-3.
82. 17{beta} estradiol regulates constitutive nitric oxide synthase expression differentially in the myocardium in response to pressure overload. Loyer X, etal., Endocrinology. 2007 Aug 2;.
83. Aberrant expression of NOS isoforms in Alzheimer's disease is structurally related to nitrotyrosine formation. Lüth HJ, etal., Brain Res. 2002 Oct 25;953(1-2):135-43.
84. Bladder outlet obstruction triggers neural plasticity in sensory pathways and contributes to impaired sensitivity in erectile dysfunction. Malykhina AP, etal., Am J Physiol Regul Integr Comp Physiol. 2013 May 15;304(10):R837-45. doi: 10.1152/ajpregu.00558.2012. Epub 2013 Mar 27.
85. Rate, affinity and calcium dependence of nitric oxide synthase isoform binding to the primary physiological regulator calmodulin. McMurry JL, etal., FEBS J. 2011 Dec;278(24):4943-54. doi: 10.1111/j.1742-4658.2011.08395.x. Epub 2011 Nov 11.
86. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
87. Specific role of neuronal nitric-oxide synthase when tethered to the plasma membrane calcium pump in regulating the beta-adrenergic signal in the myocardium. Mohamed TM, etal., J Biol Chem. 2009 May 1;284(18):12091-8. doi: 10.1074/jbc.M809112200. Epub 2009 Mar 10.
88. Expression of the skeletal muscle dystrophin-dystroglycan complex and syntrophin-nitric oxide synthase complex is severely affected in the type 2 diabetic Goto-Kakizaki rat. Mulvey C, etal., Eur J Cell Biol. 2005 Nov;84(11):867-83.
89. Chronic ethanol exposure differentially regulates NOS1 mRNA levels depending on rat brain area. Naassila M, etal., Neurosci Lett. 2003 Mar 6;338(3):221-4.
90. Changes in nitric oxide and expression of nitric oxide synthase in spinal cord after acute traumatic injury in rats. Nakahara S, etal., J Neurotrauma 2002 Nov;19(11):1467-74.
91. Nitric oxide synthase immunolocalization and expression in the rat hippocampus after sub-acute lead acetate exposure in rats. Nava-Ruiz C, etal., Exp Toxicol Pathol. 2010 May;62(3):311-6. Epub 2009 Jun 12.
92. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
93. Downregulation of nitric oxide synthase in nephrotic syndrome: role of proteinuria. Ni Z and Vaziri ND, Biochim Biophys Acta. 2003 Jul 14;1638(2):129-37.
94. Oxidative stress in the rats brain capillaries in sepsis--the influence of 7-nitroindazole. Ninkovic M, etal., Acta Physiol Hung. 2006 Dec;93(4):315-23.
95. Functionally important role for arginase 1 in the airway hyperresponsiveness of asthma. North ML, etal., Am J Physiol Lung Cell Mol Physiol. 2009 Jun;296(6):L911-20. Epub 2009 Mar 13.
96. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
97. Phosphorylation of neuronal nitric oxide synthase at Ser in the dentate gyrus of rat brain after transient forebrain ischemia. Osuka K, etal., Neurochem Int. 2013 Jun 24;63(4):269-274. doi: 10.1016/j.neuint.2013.06.011.
98. The effect of regular exercise on penile nitric oxide synthase expression in rats. Ozbek E, etal., Int J Androl. 2010 Aug 1;33(4):623-8. Epub 2009 Sep 26.
99. Information processing deficits and nitric oxide signalling in the phencyclidine model of schizophrenia. Palsson E, etal., Psychopharmacology (Berl). 2010 Dec;212(4):643-51. Epub 2010 Aug 28.
100. A conserved aspartate (Asp-1393) regulates NADPH reduction of neuronal nitric-oxide synthase: implications for catalysis. Panda K, etal., J Biol Chem 2004 Apr 30;279(18):18323-33. Epub 2004 Feb 13.
101. Neuronal nitric oxide inhibits intestinal smooth muscle growth. Pelletier AM, etal., Am J Physiol Gastrointest Liver Physiol. 2010 Jun;298(6):G896-907. Epub 2010 Mar 25.
102. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
103. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
104. Neuronal nitric oxide synthase: expression in rat parietal cells. Premaratne S, etal., Am J Physiol Gastrointest Liver Physiol 2001 Feb;280(2):G308-13.
105. [Effect of ligustrazine on cell proliferation in subventricular zone in rat brain with focal cerebral ischemia-reperfusion injury] Qi CF, etal., Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2007 Jun;32(3):396-400.
106. [Effects of shenshuai II recipe on the protein expressions of Ang II and nNOS in chronic renal failure rats' nephridial tissue]. Qin JY, etal., Zhongguo Zhong Xi Yi Jie He Za Zhi. 2012 Sep;32(9):1280-4.
107. Association of a functional NOS1 promoter repeat with Alzheimer's disease in the VITA cohort. Reif A, etal., J Alzheimers Dis. 2011;23(2):327-33. doi: 10.3233/JAD-2010-101491.
108. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
109. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
110. Nitric oxide synthase expression and effects of nitric oxide modulation on contractility of rat extraocular muscle. Richmonds CR and Kaminski HJ, FASEB J 2001 Aug;15(10):1764-70.
111. Binding of neuronal nitric-oxide synthase (nNOS) to carboxyl-terminal-binding protein (CtBP) changes the localization of CtBP from the nucleus to the cytosol: a novel function for targeting by the PDZ domain of nNOS. Riefler GM and Firestein BL, J Biol Chem. 2001 Dec 21;276(51):48262-8. Epub 2001 Oct 5.
112. Neuronal nitric oxide synthase within paraventricular nucleus: blood pressure and baroreflex in two-kidney, one-clip hypertensive rats. Rossi NF, etal., Exp Physiol. 2010 Aug;95(8):845-57. Epub 2010 May 21.
113. Nitric oxide affects the phosphorylation state of microtubule-associated protein 2 (MAP-2) and neurofilament: an immunocytochemical study in the brain of rats and neuronal nitric oxide synthase (nNOS)-knockouts. Rothe F, etal., Nitric Oxide 2002 Feb;6(1):9-17.
114. Nitric oxide synthase localization in the rat neutrophils: immunocytochemical, molecular, and biochemical studies. Saini R, etal., J Leukoc Biol. 2006 Mar;79(3):519-28. Epub 2005 Dec 30.
115. The plasmamembrane calmodulin-dependent calcium pump: a major regulator of nitric oxide synthase I. Schuh K, etal., J Cell Biol. 2001 Oct 15;155(2):201-5. Epub 2001 Oct 8.
116. 1-Methyl-4-phenylpyridinium-induced apoptosis in cerebellar granule neurons is mediated by transferrin receptor iron-dependent depletion of tetrahydrobiopterin and neuronal nitric-oxide synthase-derived superoxide. Shang T, etal., J Biol Chem. 2004 Apr 30;279(18):19099-112. doi: 10.1074/jbc.M400101200. Epub 2004 Jan 29.
117. Linkage and association of childhood asthma with the chromosome 12 genes. Shao C, etal., J Hum Genet. 2004;49(3):115-22. Epub 2004 Feb 7.
118. A combination of tumor necrosis factor-alpha and neuronal nitric oxide synthase antibodies applied topically over the traumatized spinal cord enhances neuroprotection and functional recovery in the rat. Sharma HS Ann N Y Acad Sci. 2010 Jun;1199:175-85.
119. Angiotensin II-mediated post-translational modification of nNOS in the PVN of rats with CHF: Role for PIN. Sharma NM, etal., Am J Physiol Heart Circ Physiol. 2013 Jul 5.
120. nNOS expression in reactive astrocytes correlates with increased cell death related DNA damage in the hippocampus and entorhinal cortex in Alzheimer's disease. Simic G, etal., Exp Neurol. 2000 Sep;165(1):12-26. doi: 10.1006/exnr.2000.7448.
121. Intrauterine growth restriction and shallower implantation site in rats with maternal hyperinsulinemia are associated with altered NOS expression. Skarzinski G, etal., Placenta. 2009 Oct;30(10):898-906. Epub 2009 Aug 25.
122. Renal nitric oxide production in rat pregnancy: role of constitutive nitric oxide synthases. Smith CA, etal., Am J Physiol Renal Physiol. 2010 Oct;299(4):F830-6. Epub 2010 Jul 14.
123. Heat-shock protein 90 augments neuronal nitric oxide synthase activity by enhancing Ca2+/calmodulin binding. Song Y, etal., Biochem J. 2001 Apr 15;355(Pt 2):357-60.
124. Arginase modulates myocardial contractility by a nitric oxide synthase 1-dependent mechanism. Steppan J, etal., Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4759-64. Epub 2006 Mar 13.
125. Spectral characterization of brain and macrophage nitric oxide synthases. Cytochrome P-450-like hemeproteins that contain a flavin semiquinone radical. Stuehr DJ and Ikeda-Saito M, J Biol Chem. 1992 Oct 15;267(29):20547-50.
126. Induction of NOS and nitrotyrosine expression in the rat striatum following experimental hepatic encephalopathy. Suarez I, etal., Metab Brain Dis. 2009 Sep;24(3):395-408.
127. The expression of nNOS, iNOS and nitrotyrosine is increased in the rat cerebral cortex in experimental hepatic encephalopathy. Suarez I, etal., Neuropathol Appl Neurobiol. 2006 Dec;32(6):594-604.
128. Renal neuronal nitric oxide synthase protein expression as a marker of renal injury. Szabo AJ, etal., Kidney Int. 2003 Nov;64(5):1765-71. doi: 10.1046/j.1523-1755.2003.00260.x.
129. Gene-based anchoring of the rat genetic linkage and cytogenetic maps: new regional localizations, orientation of the linkage groups, and insights into mammalian chromosome evolution. Szpirer C, etal., Mamm Genome 1998 Sep;9(9):721-34
130. Vitamin E reduces glomerulosclerosis, restores renal neuronal NOS, and suppresses oxidative stress in the 5/6 nephrectomized rat. Tain YL, etal., Am J Physiol Renal Physiol. 2007 May;292(5):F1404-10. Epub 2007 Jan 2.
131. Subcellular distribution of nitric oxide synthase isoforms in the rat duodenum. Talapka P, etal., World J Gastroenterol. 2011 Feb 28;17(8):1026-9.
132. Neuronal nitric oxide mediates cerebral vasodilatation during acute hypertension. Talman WT and Nitschke Dragon D, Brain Res. 2007 Mar 30;1139:126-32. Epub 2007 Jan 8.
133. Brain neuronal nitric oxide synthase neuron-mediated sympathoinhibition is enhanced in hypertensive Dahl rats. Tandai-Hiruma M, etal., J Hypertens. 2005 Apr;23(4):825-34.
134. A bridging interaction allows calmodulin to activate NO synthase through a bi-modal mechanism. Tejero J, etal., J Biol Chem. 2010 Aug 20;285(34):25941-9. doi: 10.1074/jbc.M110.126797. Epub 2010 Jun 7.
135. Nitric oxide synthase 1 as a potential modifier gene of decline in lung function in patients with cystic fibrosis. Texereau J, etal., Thorax. 2004 Feb;59(2):156-8.
136. Renal cortical regulation of COX-1 and functionally related products in early renovascular hypertension (rat). Theilig F, etal., Am J Physiol Renal Physiol. 2006 Nov;291(5):F987-94. Epub 2006 Jun 20.
137. Epithelial COX-2 expression is not regulated by nitric oxide in rodent renal cortex. Theilig F, etal., Hypertension 2002 Apr;39(4):848-53.
138. Neuronal nitric oxide synthase and N-methyl-D-aspartate neurons in experimental carbon monoxide poisoning. Thom SR, etal., Toxicol Appl Pharmacol. 2004 Feb 1;194(3):280-95. doi: 10.1016/j.taap.2003.09.017.
139. Syntrophin mutation associated with long QT syndrome through activation of the nNOS-SCN5A macromolecular complex. Ueda K, etal., Proc Natl Acad Sci U S A. 2008 Jul 8;105(27):9355-60. doi: 10.1073/pnas.0801294105. Epub 2008 Jun 30.
140. Activation of signaling molecules and matrix metalloproteinases in right ventricular myocardium of rats with pulmonary hypertension. Umar S, etal., Pathol Res Pract. 2007;203(12):863-72. Epub 2007 Oct 29.
141. 2-Aminopyridines with a shortened amino sidechain as potent, selective, and highly permeable human neuronal nitric oxide synthase inhibitors. Vasu D, etal., Bioorg Med Chem. 2022 Sep 1;69:116878. doi: 10.1016/j.bmc.2022.116878. Epub 2022 Jun 11.
142. Nitric oxide synthase in retina and optic nerve head of rat with increased intraocular pressure and effect of timolol. Vidal L, etal., Brain Res Bull. 2006 Oct 16;70(4-6):406-13. Epub 2006 Aug 7.
143. Nitricoxide synthase-induced oxidative stress in prolonged alcoholic myopathies of rats. Wang J, etal., Mol Cell Biochem. 2007 Jul 3;.
144. The effects of NOS1 gene on asthma and total IgE levels in Taiwanese children, and the interactions with environmental factors. Wang TN, etal., Pediatr Allergy Immunol. 2010 Nov;21(7):1064-71. doi: 10.1111/j.1399-3038.2009.00981.x.
145. Effects of nNOS antisense in the paraventricular nucleus on blood pressure and heart rate in rats with heart failure. Wang Y, etal., Am J Physiol Heart Circ Physiol. 2005 Jan;288(1):H205-13. Epub 2004 Aug 26.
146. Hypoxia induces a functionally significant and translationally efficient neuronal NO synthase mRNA variant. Ward ME, etal., J Clin Invest. 2005 Nov;115(11):3128-39.
147. Kainate-induced seizures alter protein composition and N-methyl-D-aspartate receptor function of rat forebrain postsynaptic densities. Wyneken U, etal., Neuroscience. 2001;102(1):65-74.
148. [Effect of electroacupuncture on expression of spinal neuronal nitric oxide synthase protein and mRNA in rats with neuropathic pain]. Yan LP, etal., Zhen Ci Yan Jiu. 2012 Oct;37(5):345-50.
149. Water deprivation increases the expression of neuronal nitric oxide synthase (nNOS) but not orexin-A in the lateral hypothalamic area of the rat. Yao ST, etal., J Comp Neurol. 2005 Sep 19;490(2):180-93. doi: 10.1002/cne.20662.
150. In vitro and in vivo induction and activation of nNOS by LPS in oligodendrocytes. Yao SY, etal., J Neuroimmunol. 2010 Dec 15;229(1-2):146-56. Epub 2010 Aug 19.
151. Effects of doxazosin on blood flow and mRNA expression of nitric oxide synthase in the spontaneously hypertensive rat genitourinary tract. Yono M, etal., Life Sci. 2007 Jun 27;81(3):218-22. Epub 2007 May 21.
152. Gene transfer of the neuronal NO synthase isoform to cirrhotic rat liver ameliorates portal hypertension. Yu Q, etal., J Clin Invest. 2000 Mar;105(6):741-8. doi: 10.1172/JCI7997.
153. Spatial and temporal correlation of nitric oxide synthase expression with CuZn-superoxide dismutase reduction in motor neurons following axotomy. Yu WH Ann N Y Acad Sci 2002 May;962:111-21.
154. Nan fang yi ke da xue xue bao = Journal of Southern Medical University Yuan AH, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2007 Apr;27(4):454-7.
155. nNOS Translocates into the Nucleus and Interacts with Sox2 to Protect Neurons Against Early Excitotoxicity via Promotion of Shh Transcription. Zhang D, etal., Mol Neurobiol. 2016 Nov;53(9):6444-6458. doi: 10.1007/s12035-015-9545-z. Epub 2015 Nov 25.
156. Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation. Zhang T, etal., Genome Res 2004 Jan;14(1):79-89. Epub 2003 Dec 12.
157. Perinatal food restriction impaired spatial learning and memory behavior and decreased the density of nitric oxide synthase neurons in the hippocampus of adult male rat offspring. Zhang Y, etal., Toxicol Lett. 2010 Mar 15;193(2):167-72. Epub 2010 Jan 14.
158. Effect of octreotide on enteric motor neurons in experimental acute necrotizing pancreatitis. Zhou H, etal., PLoS One. 2012;7(12):e52163. doi: 10.1371/journal.pone.0052163. Epub 2012 Dec 26.
Additional References at PubMed
PMID:1689048   PMID:7520037   PMID:7530005   PMID:7545544   PMID:8806605   PMID:9294118   PMID:9353265   PMID:9705156   PMID:9892689   PMID:10037495   PMID:10221915   PMID:10995443  
PMID:11122378   PMID:11158245   PMID:11161466   PMID:11237702   PMID:11473123   PMID:11884406   PMID:11890976   PMID:11903126   PMID:11910531   PMID:12074580   PMID:12079493   PMID:12091378  
PMID:12154090   PMID:12167608   PMID:12184796   PMID:12186546   PMID:12202479   PMID:12218415   PMID:12230824   PMID:12359874   PMID:12391089   PMID:12397095   PMID:12416720   PMID:12437343  
PMID:12472783   PMID:12495225   PMID:12533773   PMID:12577322   PMID:12638736   PMID:12663061   PMID:12675151   PMID:12699333   PMID:12834919   PMID:12847099   PMID:12923401   PMID:12933674  
PMID:14514730   PMID:14625460   PMID:14635718   PMID:14646371   PMID:14667459   PMID:14680835   PMID:14681230   PMID:14715665   PMID:14722119   PMID:14759504   PMID:14760703   PMID:14980808  
PMID:14981065   PMID:15004878   PMID:15013576   PMID:15082164   PMID:15086474   PMID:15105416   PMID:15148326   PMID:15182370   PMID:15213066   PMID:15245872   PMID:15251453   PMID:15457505  
PMID:15466472   PMID:15469880   PMID:15548660   PMID:15582712   PMID:15613739   PMID:15652699   PMID:15652701   PMID:15740979   PMID:15779894   PMID:15791049   PMID:15838302   PMID:15862534  
PMID:15935400   PMID:15950775   PMID:15972265   PMID:15990946   PMID:16003177   PMID:16014049   PMID:16023354   PMID:16150731   PMID:16174988   PMID:16191397   PMID:16224055   PMID:16239401  
PMID:16240168   PMID:16319502   PMID:16396662   PMID:16412669   PMID:16427017   PMID:16467505   PMID:16617132   PMID:16690617   PMID:16739165   PMID:16778061   PMID:16781079   PMID:16782703  
PMID:16864944   PMID:16865779   PMID:16879602   PMID:16925472   PMID:16965914   PMID:16973934   PMID:17001078   PMID:17009099   PMID:17056016   PMID:17098364   PMID:17113051   PMID:17161399  
PMID:17170237   PMID:17182010   PMID:17198704   PMID:17242280   PMID:17293453   PMID:17439487   PMID:17443799   PMID:17452640   PMID:17630350   PMID:17647138   PMID:17666041   PMID:17670980  
PMID:17822843   PMID:17850874   PMID:17873365   PMID:17892502   PMID:17892518   PMID:17901243   PMID:17904695   PMID:17951367   PMID:17977909   PMID:17997045   PMID:18020458   PMID:18048451  
PMID:18067590   PMID:18074109   PMID:18095156   PMID:18157660   PMID:18207612   PMID:18234741   PMID:18283102   PMID:18326806   PMID:18331476   PMID:18391107   PMID:18436211   PMID:18464528  
PMID:18467447   PMID:18512210   PMID:18586551   PMID:18592222   PMID:18625229   PMID:18661235   PMID:18706882   PMID:18834924   PMID:18852262   PMID:18976964   PMID:18980714   PMID:19038221  
PMID:19041855   PMID:19073653   PMID:19084437   PMID:19104001   PMID:19120105   PMID:19162106   PMID:19187438   PMID:19238548   PMID:19292454   PMID:19328480   PMID:19340531   PMID:19372221  
PMID:19412649   PMID:19523995   PMID:19615412   PMID:19646435   PMID:19691141   PMID:19769951   PMID:19800018   PMID:19846045   PMID:19889864   PMID:19923416   PMID:19924493   PMID:19931630  
PMID:19948738   PMID:20008826   PMID:20014403   PMID:20018145   PMID:20044475   PMID:20056918   PMID:20104578   PMID:20112741   PMID:20149028   PMID:20232214   PMID:20335319   PMID:20371700  
PMID:20397260   PMID:20492351   PMID:20667480   PMID:20684262   PMID:20707900   PMID:20718865   PMID:20731778   PMID:20736047   PMID:20862803   PMID:21125397   PMID:21155253   PMID:21158118  
PMID:21189546   PMID:21244098   PMID:21245950   PMID:21255634   PMID:21535296   PMID:21595896   PMID:21608012   PMID:21651902   PMID:21664432   PMID:21681338   PMID:21763759   PMID:21780165  
PMID:21813683   PMID:21831995   PMID:21840380   PMID:21847584   PMID:21960957   PMID:21968757   PMID:22128174   PMID:22198001   PMID:22316281   PMID:22370956   PMID:22391324   PMID:22445759  
PMID:22486744   PMID:22531298   PMID:22576624   PMID:22672990   PMID:22687613   PMID:22687614   PMID:22722929   PMID:22860427   PMID:22902770   PMID:22909987   PMID:22921486   PMID:22923618  
PMID:22992730   PMID:23012472   PMID:23022956   PMID:23059423   PMID:23109339   PMID:23155193   PMID:23216343   PMID:23285183   PMID:23324998   PMID:23406748   PMID:23406756   PMID:23419891  
PMID:23454199   PMID:23489187   PMID:23507581   PMID:23564306   PMID:23575992   PMID:23624088   PMID:23681475   PMID:23685166   PMID:23789902   PMID:23953569   PMID:24025168   PMID:24069609  
PMID:24186360   PMID:24329704   PMID:24477538   PMID:24495843   PMID:24499461   PMID:24512289   PMID:24562683   PMID:24680940   PMID:24707733   PMID:24731840   PMID:24740233   PMID:24908089  
PMID:24958506   PMID:24961237   PMID:25194041   PMID:25216050   PMID:25312245   PMID:25399920   PMID:25540233   PMID:25598224   PMID:25726374   PMID:25804308   PMID:25931508   PMID:25947172  
PMID:26035438   PMID:26084225   PMID:26115586   PMID:26352281   PMID:26400279   PMID:26438559   PMID:26491965   PMID:26585490   PMID:26797190   PMID:26945078   PMID:26995406   PMID:27116881  
PMID:27171264   PMID:27225184   PMID:27371683   PMID:27377302   PMID:27529477   PMID:27534879   PMID:27541371   PMID:27562066   PMID:27624386   PMID:27686338   PMID:27760279   PMID:27761804  
PMID:27903582   PMID:27960152   PMID:28087360   PMID:28089352   PMID:28126743   PMID:28232486   PMID:28430607   PMID:28720408   PMID:28921679   PMID:29016640   PMID:29074292   PMID:29182640  
PMID:29382335   PMID:29687838   PMID:29983399   PMID:30066461   PMID:30108200   PMID:30627906   PMID:30926606   PMID:31463706   PMID:31492421   PMID:31642335   PMID:31989159   PMID:32070010  
PMID:32573772   PMID:33181440   PMID:33296434   PMID:34203264   PMID:34536522   PMID:35055166   PMID:35563364   PMID:36964568   PMID:37442439   PMID:38100901   PMID:38747545  


Genomics

Comparative Map Data
Nos1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81244,276,011 - 44,456,371 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1244,287,614 - 44,371,837 (-)EnsemblGRCr8
mRatBN7.21238,615,111 - 38,795,492 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1238,626,714 - 38,710,945 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1239,802,061 - 39,886,285 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01240,415,854 - 40,500,100 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01239,468,822 - 39,553,063 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01244,214,949 - 44,405,530 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1244,213,943 - 44,520,341 (-)Ensemblrn6Rnor6.0
Rnor_5.01246,049,288 - 46,209,569 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41239,812,500 - 39,869,484 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1240,283,655 - 40,368,674 (-)NCBICelera
RGSC_v3.11239,675,108 - 39,732,872 (-)NCBI
RH 3.4 Map12718.8RGD
RH 3.4 Map12717.0RGD
Cytogenetic Map12q16NCBI
NOS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812117,208,142 - 117,361,626 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12117,208,142 - 117,452,170 (-)Ensemblhg38GRCh38
GRCh3712117,645,947 - 117,799,431 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612116,135,362 - 116,283,965 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3412116,113,698 - 116,262,302NCBI
Celera12117,280,475 - 117,430,209 (-)NCBICelera
Cytogenetic Map12q24.22NCBI
HuRef12114,655,115 - 114,808,727 (-)NCBIHuRef
CHM1_112117,611,241 - 117,767,258 (-)NCBICHM1_1
T2T-CHM13v2.012117,189,186 - 117,342,679 (-)NCBIT2T-CHM13v2.0
Nos1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395118,004,904 - 118,096,905 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5117,919,097 - 118,096,905 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm385117,866,839 - 117,958,840 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5117,781,032 - 117,958,840 (+)Ensemblmm10GRCm38
MGSCv375118,317,128 - 118,403,822 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365118,128,149 - 118,214,843 (+)NCBIMGSCv36mm8
Celera5114,958,747 - 115,046,830 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map557.29NCBI
Nos1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545513,797,545 - 13,972,566 (+)Ensembl
ChiLan1.0NW_00495545513,797,557 - 13,978,402 (+)NCBIChiLan1.0ChiLan1.0
NOS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210125,268,855 - 125,423,277 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112125,265,237 - 125,419,664 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012114,784,232 - 114,938,385 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112118,163,655 - 118,314,005 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12118,163,655 - 118,314,005 (-)EnsemblpanPan2panpan1.1
NOS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12613,787,341 - 13,895,176 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2613,786,309 - 13,962,332 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2613,781,845 - 13,865,309 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02614,042,033 - 14,222,209 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2614,044,400 - 14,151,070 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12614,009,781 - 14,093,258 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02614,087,144 - 14,170,688 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02614,122,943 - 14,206,510 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Nos1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118154,176,906 - 154,267,437 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365585,233,459 - 5,301,414 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365585,162,471 - 5,302,488 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NOS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1435,113,184 - 35,295,944 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11435,112,898 - 35,299,297 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21437,401,967 - 37,515,427 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NOS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111112,642,374 - 112,673,882 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037132,411,769 - 132,561,385 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nos1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474716,003,969 - 16,113,165 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474715,940,614 - 16,118,051 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Nos1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11635,872,056 - 35,983,185 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Nos1
1044 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:185
Count of miRNA genes:69
Interacting mature miRNAs:74
Transcripts:ENSRNOT00000001493, ENSRNOT00000046205, ENSRNOT00000066810
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)122480502252308831Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
8693635Alc28Alcohol consumption QTL 282.70.439drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122871771850386405Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122598935552308831Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121847304152308831Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123776414551558799Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121526424852308831Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)123370043246784661Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121746497946784661Rat
1556747Calcic1Intracellular calcium level QTL 13.6platelet calcium amount (VT:0010500)platelet intracellular calcium level (CMO:0000922)123370043246784661Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)123370043251558799Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121618743852308831Rat
8693658Alc33Alcohol consumption QTL 332.10.68drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122871771849212240Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121613502952308831Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743851213550Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121847304152308831Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121613502952308831Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
631543Bp83Blood pressure QTL 835.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)124413955852308831Rat

Markers in Region
D12Mco2  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81244,375,428 - 44,375,670 (+)Marker Load Pipeline
mRatBN7.21238,714,540 - 38,714,782 (+)MAPPERmRatBN7.2
Rnor_6.01244,384,957 - 44,385,198NCBIRnor6.0
Rnor_5.01246,213,380 - 46,213,621UniSTSRnor5.0
RGSC_v3.41239,872,948 - 39,873,190RGDRGSC3.4
RGSC_v3.41239,872,949 - 39,873,190UniSTSRGSC3.4
Celera1240,372,169 - 40,372,410UniSTS
RGSC_v3.11239,736,336 - 39,736,578RGD
Cytogenetic Map12q16UniSTS
D12Rat112  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81244,275,326 - 44,275,445 (+)Marker Load Pipeline
mRatBN7.21238,614,425 - 38,614,544 (+)MAPPERmRatBN7.2
Rnor_6.01244,288,330 - 44,288,448NCBIRnor6.0
Rnor_5.01246,118,433 - 46,118,551UniSTSRnor5.0
RGSC_v3.41239,763,184 - 39,763,302UniSTSRGSC3.4
RGSC_v3.41239,763,183 - 39,763,302RGDRGSC3.4
Celera1240,272,878 - 40,272,996UniSTS
RGSC_v3.11239,626,572 - 39,626,690RGD
RH 3.4 Map12712.1RGD
RH 3.4 Map12712.1UniSTS
RH 2.0 Map12496.3RGD
SHRSP x BN Map1243.24RGD
Cytogenetic Map12q16UniSTS
RH94638  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21238,626,400 - 38,626,588 (+)MAPPERmRatBN7.2
Rnor_6.01244,215,433 - 44,215,620NCBIRnor6.0
Rnor_5.01246,048,975 - 46,049,162UniSTSRnor5.0
Celera1240,283,342 - 40,283,529UniSTS
Cytogenetic Map12q16UniSTS
RH142208  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21238,709,882 - 38,710,034 (+)MAPPERmRatBN7.2
Rnor_6.01244,380,328 - 44,380,479NCBIRnor6.0
Rnor_5.01246,208,507 - 46,208,658UniSTSRnor5.0
RGSC_v3.41239,868,422 - 39,868,573UniSTSRGSC3.4
Celera1240,367,612 - 40,367,763UniSTS
Cytogenetic Map12q16UniSTS
BE111456  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21238,572,383 - 38,572,587 (+)MAPPERmRatBN7.2
Rnor_6.01244,245,999 - 44,246,202NCBIRnor6.0
Rnor_5.01246,076,562 - 46,076,765UniSTSRnor5.0
RGSC_v3.41239,721,196 - 39,721,399UniSTSRGSC3.4
Celera1240,230,583 - 40,230,786UniSTS
RH 3.4 Map12722.4UniSTS
Cytogenetic Map12q16UniSTS
RH128260  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21238,571,133 - 38,571,347 (+)MAPPERmRatBN7.2
Rnor_6.01244,244,749 - 44,244,962NCBIRnor6.0
Rnor_5.01246,075,312 - 46,075,525UniSTSRnor5.0
RGSC_v3.41239,719,946 - 39,720,159UniSTSRGSC3.4
Celera1240,229,333 - 40,229,546UniSTS
RH 3.4 Map12707.9UniSTS
Cytogenetic Map12q16UniSTS
RH135131  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21238,571,931 - 38,572,117 (+)MAPPERmRatBN7.2
Rnor_6.01244,245,547 - 44,245,732NCBIRnor6.0
Rnor_5.01246,076,110 - 46,076,295UniSTSRnor5.0
RGSC_v3.41239,720,744 - 39,720,929UniSTSRGSC3.4
Celera1240,230,131 - 40,230,316UniSTS
RH 3.4 Map12707.9UniSTS
Cytogenetic Map12q16UniSTS
AU048529  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81244,224,499 - 44,224,725 (+)Marker Load Pipeline
mRatBN7.21238,563,599 - 38,563,825 (+)MAPPERmRatBN7.2
Rnor_6.01244,237,215 - 44,237,440NCBIRnor6.0
Rnor_5.01246,067,778 - 46,068,003UniSTSRnor5.0
RGSC_v3.41239,712,412 - 39,712,637UniSTSRGSC3.4
Celera1240,221,800 - 40,222,025UniSTS
Cytogenetic Map12q16UniSTS
GDB:437697  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21238,710,131 - 38,710,571 (+)MAPPERmRatBN7.2
Rnor_6.01244,380,577 - 44,381,016NCBIRnor6.0
Rnor_5.01246,208,756 - 46,209,195UniSTSRnor5.0
RGSC_v3.41239,868,671 - 39,869,110UniSTSRGSC3.4
Celera1240,367,861 - 40,368,300UniSTS
Cytogenetic Map12q16UniSTS
UniSTS:238074  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21238,592,125 - 38,592,591 (+)MAPPERmRatBN7.2
Rnor_6.01244,265,792 - 44,266,257NCBIRnor6.0
Rnor_5.01246,096,355 - 46,096,820UniSTSRnor5.0
RGSC_v3.41239,740,940 - 39,741,405UniSTSRGSC3.4
Celera1240,250,492 - 40,250,957UniSTS
Cytogenetic Map12q16UniSTS


Related Rat Strains
The following Strains have been annotated to Nos1
SD    


Genetic Models
This gene Nos1 is modified in the following models/strains:
BN-Nos1m1Mcwi    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 11 67 145 91 90 59 28 59 6 281 127 9 120 78 86 31 9 9

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001436392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_052799 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063271043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF008912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF008913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF128540 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ001143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ001146 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ001147 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ005845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U14522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U67309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000001493   ⟹   ENSRNOP00000001493
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1244,287,614 - 44,371,837 (-)Ensembl
mRatBN7.2 Ensembl1238,626,714 - 38,710,945 (-)Ensembl
Rnor_6.0 Ensembl1244,215,847 - 44,381,289 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000066810   ⟹   ENSRNOP00000062735
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1244,287,614 - 44,371,837 (-)Ensembl
mRatBN7.2 Ensembl1238,626,714 - 38,710,945 (-)Ensembl
Rnor_6.0 Ensembl1244,213,943 - 44,520,341 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107669   ⟹   ENSRNOP00000077880
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1238,627,934 - 38,710,945 (-)Ensembl
RefSeq Acc Id: NM_052799   ⟹   NP_434686
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81244,287,614 - 44,371,837 (-)NCBI
mRatBN7.21238,626,714 - 38,710,945 (-)NCBI
Rnor_6.01244,215,746 - 44,381,390 (-)NCBI
Rnor_5.01246,049,288 - 46,209,569 (-)NCBI
RGSC_v3.41239,812,500 - 39,869,484 (-)RGD
Celera1240,283,655 - 40,368,674 (-)RGD
Sequence:
RefSeq Acc Id: XM_039089059   ⟹   XP_038944987
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81244,276,011 - 44,396,000 (-)NCBI
mRatBN7.21238,615,111 - 38,735,132 (-)NCBI
RefSeq Acc Id: XM_039089060   ⟹   XP_038944988
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81244,276,011 - 44,456,371 (-)NCBI
mRatBN7.21238,615,111 - 38,795,492 (-)NCBI
RefSeq Acc Id: XM_063271041   ⟹   XP_063127111
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81244,276,011 - 44,395,998 (-)NCBI
RefSeq Acc Id: XM_063271042   ⟹   XP_063127112
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81244,282,462 - 44,395,997 (-)NCBI
RefSeq Acc Id: XM_063271043   ⟹   XP_063127113
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81244,282,462 - 44,395,995 (-)NCBI
RefSeq Acc Id: NP_434686   ⟸   NM_052799
- UniProtKB: D3ZEW7 (UniProtKB/TrEMBL),   A0A8I5YCJ4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001493   ⟸   ENSRNOT00000001493
Ensembl Acc Id: ENSRNOP00000062735   ⟸   ENSRNOT00000066810
RefSeq Acc Id: XP_038944988   ⟸   XM_039089060
- Peptide Label: isoform X1
- UniProtKB: A0A8I5YCJ4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038944987   ⟸   XM_039089059
- Peptide Label: isoform X1
- UniProtKB: A0A8I5YCJ4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000077880   ⟸   ENSRNOT00000107669
RefSeq Acc Id: XP_063127111   ⟸   XM_063271041
- Peptide Label: isoform X2
- UniProtKB: P70594 (UniProtKB/Swiss-Prot),   P29476 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063127112   ⟸   XM_063271042
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063127113   ⟸   XM_063271043
- Peptide Label: isoform X4
Protein Domains
FAD-binding FR-type   Flavodoxin-like   PDZ

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P29476-F1-model_v2 AlphaFold P29476 1-1429 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3184 AgrOrtholog
BioCyc Gene G2FUF-19072 BioCyc
BioCyc Pathway PWY-4983 [nitric oxide biosynthesis II (mammals)] BioCyc
BioCyc Pathway Image PWY-4983 BioCyc
Ensembl Genes ENSRNOG00000001130 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000001493 ENTREZGENE
  ENSRNOT00000066810 ENTREZGENE
Gene3D-CATH 2.30.42.10 UniProtKB/Swiss-Prot
  3.40.50.360 UniProtKB/Swiss-Prot
  3.40.50.80 UniProtKB/Swiss-Prot
  3.90.440.10 UniProtKB/Swiss-Prot
  NADPH-cytochrome p450 Reductase, Chain A, domain 3 UniProtKB/Swiss-Prot
  Nitric Oxide Synthase, Chain A, domain 1 UniProtKB/Swiss-Prot
  Nitric Oxide Synthase, Chain A, domain 3 UniProtKB/Swiss-Prot
  Translation factors UniProtKB/Swiss-Prot
InterPro CysJ-like_FAD-binding UniProtKB/Swiss-Prot
  FAD-bd_FR_type UniProtKB/Swiss-Prot
  Flavdoxin-like UniProtKB/Swiss-Prot
  Flavodoxin/NO_synth UniProtKB/Swiss-Prot
  Flavoprot_Pyr_Nucl_cyt_Rdtase UniProtKB/Swiss-Prot
  Flavoprotein-like_sf UniProtKB/Swiss-Prot
  FNR_nucleotide-bd UniProtKB/Swiss-Prot
  NADPH_Cyt_P450_Rdtase_alpha UniProtKB/Swiss-Prot
  NOS UniProtKB/Swiss-Prot
  NOS_dom_1 UniProtKB/Swiss-Prot
  NOS_dom_2 UniProtKB/Swiss-Prot
  NOS_dom_3 UniProtKB/Swiss-Prot
  NOS_euk UniProtKB/Swiss-Prot
  NOS_N UniProtKB/Swiss-Prot
  NOS_N_sf UniProtKB/Swiss-Prot
  OxRdtase_FAD/NAD-bd UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
  PDZ_sf UniProtKB/Swiss-Prot
  Riboflavin_synthase-like_b-brl UniProtKB/Swiss-Prot
KEGG Report rno:24598 UniProtKB/Swiss-Prot
NCBI Gene 24598 ENTREZGENE
PANTHER NITRIC OXIDE SYNTHASE UniProtKB/Swiss-Prot
  NITRIC OXIDE SYNTHASE OXYGENASE UniProtKB/Swiss-Prot
Pfam FAD_binding_1 UniProtKB/Swiss-Prot
  Flavodoxin_1 UniProtKB/Swiss-Prot
  NAD_binding_1 UniProtKB/Swiss-Prot
  NO_synthase UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
PhenoGen Nos1 PhenoGen
PIRSF NOS UniProtKB/Swiss-Prot
PRINTS FLAVODOXIN UniProtKB/Swiss-Prot
  FPNCR UniProtKB/Swiss-Prot
PROSITE FAD_FR UniProtKB/Swiss-Prot
  FLAVODOXIN_LIKE UniProtKB/Swiss-Prot
  NOS UniProtKB/Swiss-Prot
  PDZ UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001130 RatGTEx
SMART PDZ UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50156 UniProtKB/Swiss-Prot
  SSF52218 UniProtKB/Swiss-Prot
  SSF52343 UniProtKB/Swiss-Prot
  SSF56512 UniProtKB/Swiss-Prot
  SSF63380 UniProtKB/Swiss-Prot
UniProt A0A8I5YCJ4 ENTREZGENE
  D3ZEW7 ENTREZGENE, UniProtKB/TrEMBL
  F1LQL1 ENTREZGENE, UniProtKB/TrEMBL
  NOS1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  P70594 ENTREZGENE
  Q9QWT2_RAT UniProtKB/TrEMBL
UniProt Secondary P70594 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-10 Nos1  nitric oxide synthase 1  Nos1  nitric oxide synthase 1, neuronal  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Nos1  nitric oxide synthase 1, neuronal     nitric oxide synthase 1   Name updated 629478 APPROVED
2002-06-10 Nos1  nitric oxide synthase 1       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to mitochondrial membranes and postsynaptic densities 727494
gene_disease amyloid beta induced expression is observed in Alzheimers disease which could be a result of defective heme oxygenase 2 and carbon monoxide signaling 625673
gene_disease amyloid beta induced expression is observed in Alzheimers disease which could be a result of defective heme oxygenase 2 and carbon monoxide signaling 734540
gene_drugs mRNA level was higher in animals treated with N-(2-chloroethyl)-N-ethyl-2 bromobenzylamine (DSP4) 625673
gene_expression expressed in kidney 70545
gene_function produces nitric oxide from L-arginine and molecular oxygen 68897
gene_pathway necessary component of the signaling pathway along with light, glutamate and NMDA receptor, to reset the biological clock phase 734539
gene_pathway necessary component of the signaling pathway along with light, glutamate and NMDA receptor, to reset the biological clock phase 734540
gene_process mediator of erectile function and regulates skeletal muscle vasoconstriction, body fluid homeostasis, neuroendocrine physiology, and smooth muscle motility 68911
gene_regulation activity is inhibited by stearoylethanolamide (SEA) treatment of C6 glioma cells 625526
gene_regulation highest activity is measured at pH 6.7 in the hypothalamic suprachiasmatic nuclei 734539
gene_transcript can identify only one variable exon 1302827