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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3184
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nos1
Name: nitric oxide synthase 1
Acc ID: CHEBI:41072
Term: 3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
Definition: An indole that has formula C25H24N4O2.
Chemical ID: MESH:C070515
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos1multiple interactionsEXP 6480464CTDbisindolylmaleimide I inhibits the reaction [[EDN1 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]; bisindolylmaleimide I inhibits the reaction [[EDN3 protein binds to and results in increased activity of EDNRB protein] which results in increased activity of NOS1 protein]PMID:15245872
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