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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3184
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nos1
Name: nitric oxide synthase 1
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos1decreases expressionEXP 6480464CTDStreptozocin results in decreased expression of NOS1 mRNA; Streptozocin results in decreased expression of NOS1 proteinPMID:18528636 PMID:26006044
Nos1multiple interactionsEXP 6480464CTD1-hexacosanol inhibits the reaction [Streptozocin results in decreased expression of NOS1 mRNA]; 1-hexacosanol inhibits the reaction [Streptozocin results in decreased expression of NOS1 protein]; [Sildenafil Citrate co-treated with resveratrol] inhibits the reaction [Streptozocin results in decreased expression of NOS1 protein]; resveratrol inhibits the reaction [Streptozocin results in decreased expression of NOS1 protein]PMID:18528636 PMID:26006044
Nos1increases expressionISONos1 (Mus musculus)6480464CTDStreptozocin results in increased expression of NOS1 mRNAPMID:34896238
Nos1multiple interactionsISONos1 (Mus musculus)6480464CTDAcrylamide inhibits the reaction [Streptozocin results in increased expression of NOS1 mRNA]PMID:34896238
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