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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3184
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nos1
Name: nitric oxide synthase 1
Acc ID: CHEBI:58987
Term: sildenafil citrate
Definition: The citrate salt of sildenafil.
Chemical ID: MESH:D000068677
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos1increases expressionEXP 6480464CTDSildenafil Citrate results in increased expression of NOS1 mRNAPMID:17627722
Nos1multiple interactionsEXP 6480464CTD[Sildenafil Citrate co-treated with Resveratrol] inhibits the reaction [Streptozocin results in decreased expression of NOS1 protein]; [Sildenafil Citrate co-treated with zinc protoporphyrin] results in increased expression of NOS1 mRNA; Curcumin promotes the reaction [Sildenafil Citrate results in increased expression of NOS1 mRNA]PMID:17627722 PMID:26006044
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