RGD Reference Report - Renal cortical regulation of COX-1 and functionally related products in early renovascular hypertension (rat). - Rat Genome Database

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Renal cortical regulation of COX-1 and functionally related products in early renovascular hypertension (rat).

Authors: Theilig, F  Debiec, H  Nafz, B  Ronco, P  Nusing, R  Seyberth, HW  Pavenstadt, H  Bouby, N  Bachmann, S 
Citation: Theilig F, etal., Am J Physiol Renal Physiol. 2006 Nov;291(5):F987-94. Epub 2006 Jun 20.
RGD ID: 1642130
Pubmed: PMID:16788145   (View Abstract at PubMed)
DOI: DOI:10.1152/ajprenal.00099.2006   (Journal Full-text)

Renal volume regulation is modulated by the action of cyclooxygenases (COX) and the resulting generation of prostanoids. Epithelial expression of COX isoforms in the cortex directs COX-1 to the distal convolutions and cortical collecting duct, and COX-2 to the thick ascending limb. Partly colocalized are prostaglandin E synthase (PGES), the downstream enzyme for renal prostaglandin E(2) (PGE(2)) generation, and the EP receptors type 1 and 3. COX-1 and related components were studied in two kidney-one clip (2K1C) Goldblatt hypertensive rats with combined chronic ANG II or bradykinin B(2) receptor blockade using candesartan (cand) or the B(2) antagonist Hoechst 140 (Hoe). Rats (untreated sham, 2K1C, sham + cand, 2K1C + cand, sham + Hoe, 2K1C + Hoe) were treated to map expression of parameters controlling PGE(2) synthesis. In 2K1C, cortical COX isoforms did not change uniformly. COX-2 changed in parallel with NO synthase 1 (NOS1) expression with a raise in the clipped, but a decrease in the nonclipped side. By contrast, COX-1 and PGES were uniformly downregulated in both kidneys, along with reduced urinary PGE(2) levels, and showed no clear relations with the NO status. ANG II receptor blockade confirmed negative regulation of COX-2 by ANG II but blunted the decrease in COX-1 selectively in nonclipped kidneys. B(2) receptor blockade reduced COX-2 induction in 2K1C but had no clear effect on COX-1. We suggest that in 2K1C, COX-1 and PGES expression may fail to oppose the effects of renovascular hypertension through reduced prostaglandin signaling in late distal tubule and cortical collecting duct.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
renovascular hypertension  ISONos1 (Rattus norvegicus)1642130; 1642130 RGD 
renovascular hypertension  IEP 1642130 RGD 
renovascular hypertension  ISOPtger3 (Rattus norvegicus)1642130; 1642130protein:increased expression:kidney (rat)RGD 
renovascular hypertension  IEP 1642130protein:increased expression:kidney (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Nos1  (nitric oxide synthase 1)
Ptger3  (prostaglandin E receptor 3)

Genes (Mus musculus)
Nos1  (nitric oxide synthase 1, neuronal)
Ptger3  (prostaglandin E receptor 3 (subtype EP3))

Genes (Homo sapiens)
NOS1  (nitric oxide synthase 1)
PTGER3  (prostaglandin E receptor 3)


Additional Information