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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3184
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nos1
Name: nitric oxide synthase 1
Acc ID: CHEBI:6809
Term: methamphetamine
Definition: A member of the class of amphetamines in which the amino group of (S)-amphetamine carries a methyl substituent.
Chemical ID: MESH:D008694
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos1affects response to substanceISONos1 (Mus musculus)6480464CTDNOS1 protein affects the susceptibility to MethamphetaminePMID:11085313 PMID:11158245 PMID:12050851 PMID:15542708 PMID:20575850 PMID:9495865
Nos1increases expressionISONos1 (Mus musculus)6480464CTDMethamphetamine results in increased expression of NOS1 proteinPMID:10642852
Nos1multiple interactionsISONos1 (Mus musculus)6480464CTD[3-bromo-7-nitroindazole results in decreased activity of NOS1 protein] which affects the susceptibility to Methamphetamine; [7-nitroindazole results in decreased activity of NOS1 protein] which affects the susceptibility to Methamphetamine; [7-nitroindazole results in decreased activity of NOS1 protein] which results in decreased susceptibility to Methamphetamine; [S-methylthiocitrulline results in decreased activity of NOS1 protein] which affects the susceptibility to Methamphetamine; NOS1 protein affects the reaction [Methamphetamine inhibits the reaction [Mazindol binds to SLC6A3 protein]]; NOS1 protein affects the reaction [Methamphetamine results in decreased abundance of 3,4-Dihydroxyphenylacetic Acid]; NOS1 protein affects the reaction [Methamphetamine results in decreased abundance of Dopamine]; NOS1 protein affects the reaction [Methamphetamine results in decreased abundance of Homovanillic Acid]; NOS1 protein affects the reaction [Methamphetamine results in decreased expression of BCL2 protein]; NOS1 protein affects the reaction [Methamphetamine results in decreased expression of SLC6A3 protein]; NOS1 protein affects the reaction [Methamphetamine results in increased expression of TRP53 protein]PMID:11006970 PMID:11085313 PMID:11457507 PMID:17426488 PMID:20575850 PMID:8858965 PMID:9495865
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