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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3184
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nos1
Name: nitric oxide synthase 1
Acc ID: CHEBI:31767
Term: lead diacetate
Definition: A lead coordination entity in which a central lead(2+) atom is coordinated to two acetate ions.
Chemical ID: MESH:C008261
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos1increases expressionEXP 6480464CTDlead acetate results in increased expression of NOS1 proteinPMID:11454931 PMID:21195594
Nos1multiple interactionsEXP 6480464CTDtempol inhibits the reaction [lead acetate results in increased expression of NOS1 protein]PMID:11454931
Nos1decreases expressionISONos1 (Mus musculus)6480464CTDlead acetate results in decreased expression of NOS1 proteinPMID:23501611 PMID:23855546
Nos1multiple interactionsISONos1 (Mus musculus)6480464CTD[lead acetate results in increased abundance of Lead] which results in decreased expression of NOS1 protein; puerarin inhibits the reaction [lead acetate results in decreased expression of NOS1 protein]; Quercetin inhibits the reaction [lead acetate results in decreased expression of NOS1 protein]PMID:23501611 PMID:23855546 PMID:26660114
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