Kdr (kinase insert domain receptor) - Rat Genome Database

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Gene: Kdr (kinase insert domain receptor) Rattus norvegicus
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Symbol: Kdr
Name: kinase insert domain receptor
RGD ID: 2965
Description: Enables growth factor binding activity and vascular endothelial growth factor receptor activity. Involved in several processes, including positive regulation of endothelial cell proliferation; positive regulation of intracellular signal transduction; and positive regulation of long-term neuronal synaptic plasticity. Located in neuronal cell body. Used to study adhesions of uterus; brain ischemia; cystitis; and myocardial infarction. Biomarker of several diseases, including artery disease (multiple); impotence; ovarian hyperstimulation syndrome; prostate disease (multiple); and retinopathy of prematurity. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); breast angiosarcoma; gastrointestinal system cancer (multiple); macular degeneration (multiple); and pancreatic cancer (multiple). Orthologous to human KDR (kinase insert domain receptor); PARTICIPATES IN altered vascular endothelial growth factor signaling pathway involving proteins affecting its expression; altered vascular endothelial growth factor signaling pathway involving the main players; vascular endothelial growth factor signaling pathway; INTERACTS WITH (S)-naringenin; (S)-nicotine; 1,2,4-trimethylbenzene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: fetal liver kinase 1; FLK-1; FLK1 kinase insert domain receptor (a type III receptor tyrosine kinase) (VEGF receptor 2); FLK1 kinase insert domain receptor (VEGF receptor 2); kinase insert domain protein receptor; MGC93590; protein-tyrosine kinase receptor flk-1; vascular endothelial growth factor receptor 2; Vegfr-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81432,572,031 - 32,615,204 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1432,572,049 - 32,615,192 (+)EnsemblGRCr8
mRatBN7.21432,217,871 - 32,261,018 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1432,217,871 - 32,261,018 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1432,577,934 - 32,621,098 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01433,885,873 - 33,929,041 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01432,370,973 - 32,414,143 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01434,727,677 - 34,787,127 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1434,727,623 - 34,787,183 (+)Ensemblrn6Rnor6.0
Rnor_5.01434,557,361 - 34,618,112 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera1431,512,534 - 31,554,989 (+)NCBICelera
Cytogenetic Map14p11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
Acute Lung Injury  (IEP)
adenocarcinoma  (ISO)
adhesions of uterus  (IMP,ISO)
allergic contact dermatitis  (ISO)
amyotrophic lateral sclerosis  (ISO)
angiosarcoma  (ISO)
Animal Mammary Neoplasms  (ISO)
arteriosclerosis  (IEP,ISO)
arteriovenous malformations of the brain  (ISO)
asthma  (ISO)
atherosclerosis  (ISO)
brain glioma  (ISO)
Brain Hypoxia-Ischemia  (IMP)
Brain Injuries  (IEP,IMP)
brain ischemia  (IMP)
breast angiosarcoma  (ISO)
breast cancer  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
cerebral cavernous malformation  (ISO)
Cerebral Hemorrhage  (ISO)
Choroidal Neovascularization  (IDA,IMP,ISO)
chronic obstructive pulmonary disease  (ISO)
colitis  (IEP)
colon carcinoma  (ISO)
Colonic Neoplasms  (ISO)
colorectal adenocarcinoma  (ISO)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
contact dermatitis  (ISO)
corneal neovascularization  (ISO)
Coronary Disease  (ISO)
Crohn's disease  (ISO)
cystitis  (IDA)
decubitus ulcer  (ISO)
Diabetic Nephropathies  (ISO)
diffuse scleroderma  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
endometriosis  (IEP)
Esophageal Neoplasms  (ISO)
esophagus adenocarcinoma  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (IDA,ISO)
Eye Neoplasms  (ISO)
glioblastoma  (ISO)
Hand-Foot Syndrome  (ISO)
hemangiopericytoma  (ISO)
hepatoblastoma  (ISO)
hepatocellular carcinoma  (ISO)
herpes simplex virus keratitis  (ISO)
high grade glioma  (ISO)
High Myopia  (ISO)
Hirschsprung's disease  (ISO)
hydrophthalmos  (ISO)
hypertension  (IEP,ISO)
impotence  (IEP)
Infantile Capillary Hemangioma  (ISO)
inverted papilloma  (ISO)
Kidney Neoplasms  (ISO)
Kuhnt-Junius degeneration  (ISO)
Lathyrism  (IEP)
limited scleroderma  (ISO)
liver cirrhosis  (ISO)
lung carcinoma  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lymphangioma  (ISO)
Lymphatic Metastasis  (ISO)
macular degeneration  (ISO)
macular retinal edema  (ISO)
melanoma  (ISO)
myocardial infarction  (IDA,ISO)
Myocardial Ischemia  (ISO)
Nasal Polyps  (ISO)
nasopharynx carcinoma  (ISO)
Neoplasm Metastasis  (ISO)
Neovascularization, Pathologic  (ISO)
Neuralgia  (IEP)
neurilemmoma  (ISO)
neurofibrosarcoma  (ISO)
osteochondrodysplasia  (ISO)
Otitis Media with Effusion  (IEP)
ovarian hyperstimulation syndrome  (IEP)
Ovarian Neoplasms  (ISO)
Oxygen-Induced Retinopathy  (IEP,IMP)
pancreatic cancer  (ISO)
pancreatic carcinoma  (ISO)
primary ovarian insufficiency  (ISO)
prostate adenocarcinoma  (IEP,ISO)
prostate cancer  (ISO)
prostatic hypertrophy  (IEP)
psoriasis  (ISO)
pterygium  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (IEP,ISO)
retinal telangiectasia  (ISO)
retinopathy of prematurity  (IEP,ISO)
salivary gland carcinoma  (ISO)
sarcoma  (ISO)
schizophrenia  (ISO)
Seasonal Allergic Rhinitis  (ISO)
Spinal Cord Injuries  (IEP)
squamous cell carcinoma  (ISO)
stomach cancer  (ISO)
stroke  (IMP)
systemic scleroderma  (ISO)
temporal lobe epilepsy  (ISO)
teratoma  (ISO)
tetralogy of Fallot  (ISO)
thyroid gland carcinoma  (ISO)
tongue squamous cell carcinoma  (ISO)
transitional cell carcinoma  (ISO)
Transplant Rejection  (ISO)
Tufted Angioma  (ISO)
type 2 diabetes mellitus  (ISO)
ulcerative colitis  (ISO)
uremia  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)
uveal melanoma  (ISO)
Venous Thrombosis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(S)-naringenin  (EXP)
(S)-nicotine  (EXP)
1,1-dichloroethene  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1,4-benzoquinone  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,3-Bis(3-hydroxybenzyl)butane-1,4-diol  (ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-tert-butylhydroquinone  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',5,5'-tetraiodothyroacetic acid  (ISO)
3,3'-diindolylmethane  (ISO)
3,5,6-trichloro-2-pyridinol  (ISO)
3,5,6-trichloropyridine-2-one  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-azacytidine  (EXP)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
amitrole  (EXP)
andrographolide  (ISO)
apigenin  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
aspartame  (ISO)
Auriculasin  (ISO)
baicalin  (EXP)
belinostat  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
benzylpenicillin  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
cadmium atom  (ISO)
calcidiol  (EXP)
calcitriol  (EXP)
calcium atom  (ISO)
calcium silicate  (ISO)
calcium(0)  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
clozapine  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
cordycepin  (ISO)
corticosterone  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
curcumin  (EXP,ISO)
Curcumol  (EXP,ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
cypermethrin  (ISO)
D-glucose  (ISO)
deguelin  (ISO)
demethoxycurcumin  (ISO)
desferrioxamine B  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (EXP)
dihydrogen  (EXP)
dioscin  (ISO)
dioxygen  (EXP,ISO)
diprotium  (EXP)
diquat  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
embelin  (ISO)
enalapril  (EXP)
Enterolactone  (ISO)
entinostat  (ISO)
ethanol  (ISO)
ethyl trans-caffeate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fructose  (EXP)
fumonisin B1  (ISO)
furosemide  (EXP)
Fusaproliferin  (EXP)
galaxolide  (ISO)
gefitinib  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
geraniol  (ISO)
glafenine  (EXP)
glucose  (ISO)
glycidol  (EXP)
glyphosate  (ISO)
haloperidol  (ISO)
harmaline  (ISO)
hexachlorobenzene  (ISO)
indoles  (EXP)
isoprenaline  (ISO)
kaempferol  (EXP)
L-ascorbic acid  (ISO)
L-ethionine  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
linderalactone  (ISO)
lipopolysaccharide  (EXP)
lithium chloride  (ISO)
losartan  (EXP)
medroxyprogesterone acetate  (ISO)
melatonin  (ISO)
melittin  (ISO)
methimazole  (EXP)
methoxychlor  (EXP)
methyl caffeate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
MK-2206  (EXP)
monocrotaline  (ISO)
monosodium L-glutamate  (EXP)
Morroniside  (EXP)
N-acetyl-L-cysteine  (ISO)
N-acetylsphingosine  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (EXP)
nickel atom  (ISO)
nicotine  (EXP)
nicotinic acid  (ISO)
nitrofen  (EXP)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
omeprazole  (EXP,ISO)
orantinib  (ISO)
orlistat  (ISO)
oxaliplatin  (EXP)
oxybenzone  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
PD123319  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP)
phenylephrine  (EXP)
phenytoin  (ISO)
phosgene  (EXP,ISO)
pirfenidone  (ISO)
pirinixic acid  (EXP,ISO)
platycodin D  (ISO)
ponatinib  (ISO)
Ponicidin  (ISO)
potassium dichromate  (ISO)
progesterone  (EXP,ISO)
quercetin  (ISO)
quercitrin  (ISO)
quinacrine  (ISO)
quinazolines  (ISO)
resveratrol  (ISO)
Rhein  (EXP)
riddelliine  (EXP)
rosuvastatin calcium  (ISO)
rotenone  (EXP)
saccharin  (ISO)
sarpogrelate  (ISO)
SB 431542  (ISO)
semaxanib  (EXP)
silicon dioxide  (ISO)
simvastatin  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sorafenib  (ISO)
sphingosine 1-phosphate  (ISO)
streptozocin  (EXP,ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
superoxide  (ISO)
tanespimycin  (EXP,ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thioacetamide  (EXP)
thyroxine  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
topotecan  (EXP)
trichloroethene  (EXP,ISO)
triclosan  (ISO)
triptonide  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
undecane  (EXP)
urea  (ISO)
urethane  (ISO)
valproic acid  (ISO)
valsartan  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
WIN 55212-2  (ISO)
zinc atom  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IBA,IEA)
branching involved in blood vessel morphogenesis  (ISO)
branching morphogenesis of an epithelial tube  (ISO)
calcium ion homeostasis  (ISO)
cell differentiation  (IEA)
cell fate commitment  (ISO)
cell maturation  (ISO)
cell migration  (IBA,ISO)
cell surface receptor protein tyrosine kinase signaling pathway  (IBA,IEA)
cellular response to hydrogen sulfide  (IEA,ISO)
cellular response to vascular endothelial growth factor stimulus  (IEA,ISO,ISS)
embryonic hemopoiesis  (IEA,ISO,ISS)
endocardium development  (IEA,ISO)
endochondral bone growth  (IMP)
endothelial cell differentiation  (IBA,ISO)
endothelial tube morphogenesis  (IMP)
endothelium development  (IEA,ISO,ISS)
epithelial tube morphogenesis  (IEA)
gonad development  (IEA)
hemopoiesis  (ISO)
lung alveolus development  (ISO)
lung development  (ISO)
lymph vessel development  (ISO)
male gonad development  (IDA)
negative regulation of endothelial cell apoptotic process  (IEA,ISO,ISS)
negative regulation of gene expression  (IEA,ISO)
negative regulation of neuron apoptotic process  (IEA,IMP,ISO)
negative regulation of systemic arterial blood pressure  (IGI)
neuron projection morphogenesis  (IMP)
ovarian follicle development  (ISO)
peptidyl-tyrosine phosphorylation  (ISO,ISS)
positive regulation of angiogenesis  (IBA,IDA,IEA,ISO)
positive regulation of blood vessel endothelial cell migration  (IEA,ISO)
positive regulation of BMP signaling pathway  (IEA,ISO)
positive regulation of calcium-mediated signaling  (IMP)
positive regulation of cell migration  (IBA,IEA,IMP,ISO)
positive regulation of cell migration involved in sprouting angiogenesis  (IEA,ISO)
positive regulation of cell population proliferation  (IBA,IEA,IMP,ISO)
positive regulation of cytosolic calcium ion concentration  (IMP)
positive regulation of endothelial cell chemotaxis  (IEA,ISO)
positive regulation of endothelial cell migration  (IEA,ISO)
positive regulation of endothelial cell proliferation  (IEA,IMP,ISO,ISS)
positive regulation of epithelial cell proliferation  (IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of focal adhesion assembly  (IEA,ISO)
positive regulation of long-term neuronal synaptic plasticity  (IMP)
positive regulation of macroautophagy  (ISO)
positive regulation of MAPK cascade  (IEA,ISO,ISS)
positive regulation of mesenchymal cell proliferation  (ISO)
positive regulation of mitochondrial depolarization  (ISO)
positive regulation of mitochondrial fission  (ISO)
positive regulation of neurogenesis  (IEP)
positive regulation of nitric oxide-cGMP mediated signal transduction  (ISO,ISS)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA,IMP,ISO)
positive regulation of positive chemotaxis  (IEA,ISO)
positive regulation of protein phosphorylation  (ISO,ISS)
positive regulation of signal transduction  (IEA)
positive regulation of TOR signaling  (IMP)
positive regulation of vasculogenesis  (IEA,ISO,ISS)
post-embryonic camera-type eye morphogenesis  (ISO)
protein autophosphorylation  (IDA,ISO)
regulation of bone development  (ISO)
regulation of cell shape  (IEA,ISO)
regulation of endothelial cell proliferation  (IEA)
regulation of hematopoietic progenitor cell differentiation  (ISO)
regulation of MAPK cascade  (IBA)
response to axon injury  (IEP)
response to hypoxia  (IMP)
response to oxygen levels  (IEP)
response to xenobiotic stimulus  (IMP)
semaphorin-plexin signaling pathway  (IEA,ISO)
surfactant homeostasis  (ISO)
vascular endothelial growth factor receptor signaling pathway  (IEA,IMP,ISO,ISS)
vascular endothelial growth factor receptor-2 signaling pathway  (IEA,ISO,ISS)
vascular endothelial growth factor signaling pathway  (IEA,ISO)
vascular wound healing  (IEA,ISO)
vasculogenesis  (ISO,ISS)
vasodilation  (IGI)

Cellular Component
anchoring junction  (IEA)
cell junction  (IEA,ISO,ISS)
cell periphery  (IEA,ISO)
cell surface  (IEA,ISO)
cytoplasm  (IEA,ISO)
cytoplasmic vesicle  (IEA)
cytosol  (IEA,ISO)
early endosome  (IEA,ISO)
endoplasmic reticulum  (IEA,ISO,ISS)
endosome  (IEA,ISO)
external side of plasma membrane  (IEA,ISO)
Golgi apparatus  (IEA,ISO)
membrane  (IEA)
membrane raft  (IEA,ISO)
neuronal cell body  (IDA)
nuclear membrane  (IEA,ISO)
nucleus  (IEA,ISO)
plasma membrane  (IBA,IEA,ISO,ISS)
receptor complex  (IBA)
sorting endosome  (IEA,ISO)

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Inhibition of angiogenesis by blocking activation of the vascular endothelial growth factor receptor 2 leads to decreased growth of neurogenic sarcomas. Angelov L, etal., Cancer Res. 1999 Nov 1;59(21):5536-41.
2. Prognostic importance of vascular endothelial growth factor and its receptors in the uterine sarcoma. Arita S, etal., Int J Gynecol Cancer. 2005 Mar-Apr;15(2):329-36.
3. Vascular endothelial growth factor receptor 2 expression in non-tumorous cirrhotic liver is higher when hepatoma is beyond Milan criteria. Aucejo F, etal., Liver Transpl. 2009 Feb;15(2):169-76. doi: 10.1002/lt.21678.
4. Post-infarct treatment with [Pyr(1)]apelin-13 improves myocardial function by increasing neovascularization and overexpression of angiogenic growth factors in rats. Azizi Y, etal., Eur J Pharmacol. 2015 Aug 15;761:101-8. doi: 10.1016/j.ejphar.2015.04.034. Epub 2015 May 1.
5. EGFR and VEGFR2 protein expressions in bone metastases of clear cell renal cancer. Badalian G, etal., Anticancer Res. 2007 Mar-Apr;27(2):889-94.
6. [Expression of kinase insert domain-containing receptor in prostate adenocarcinoma] Bai AS, etal., Zhonghua Nan Ke Xue. 2007 Apr;13(4):324-6.
7. Primary mammary angiosarcomas harbor frequent mutations in KDR and PIK3CA and show evidence of distinct pathogenesis. Beca F, etal., Mod Pathol. 2020 Aug;33(8):1518-1526. doi: 10.1038/s41379-020-0511-6. Epub 2020 Mar 2.
8. Pharmacological characterization of CP-547,632, a novel vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for cancer therapy. Beebe JS, etal., Cancer Res. 2003 Nov 1;63(21):7301-9.
9. Vascular endothelial growth factor and kinase domain region receptor are involved in both seminiferous cord formation and vascular development during testis morphogenesis in the rat. Bott RC, etal., Biol Reprod. 2006 Jul;75(1):56-67. Epub 2006 May 3.
10. Meta-analysis of contribution of genetic polymorphisms in drug-metabolizing enzymes or transporters to axitinib pharmacokinetics. Brennan M, etal., Eur J Clin Pharmacol. 2012 May;68(5):645-55. Epub 2011 Dec 15.
11. Expression of vascular endothelial growth factor and its receptors in the central nervous system in amyotrophic lateral sclerosis. Brockington A, etal., J Neuropathol Exp Neurol. 2006 Jan;65(1):26-36.
12. Overexpression of vascular permeability factor (VPF/VEGF) and its endothelial cell receptors in delayed hypersensitivity skin reactions. Brown LF, etal., J Immunol. 1995 Mar 15;154(6):2801-7.
13. Combined administration of G-CSF and GM-CSF stimulates monocyte-derived pro-angiogenic cells in patients with acute myocardial infarction. Bruno S, etal., Cytokine. 2006 Apr;34(1-2):56-65. Epub 2006 May 15.
14. The VEGFR2, COX-2 and MMP-2 polymorphisms are associated with clinical outcome of patients with inoperable non-small cell lung cancer. Butkiewicz D, etal., Int J Cancer. 2015 Nov 15;137(10):2332-42. doi: 10.1002/ijc.29605. Epub 2015 Jun 3.
15. VEGF links hippocampal activity with neurogenesis, learning and memory. Cao L, etal., Nat Genet. 2004 Aug;36(8):827-35. Epub 2004 Jul 18.
16. Evidence for reduced angiogenesis in bone marrow in SSc: immunohistochemistry and multiparametric computerized imaging analysis. Carrai V, etal., Rheumatology (Oxford). 2012 Jun;51(6):1042-8. doi: 10.1093/rheumatology/ker447. Epub 2012 Jan 23.
17. KDR activation in astrocytic neoplasms. Carroll RS, etal., Cancer. 1999 Oct 1;86(7):1335-41.
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47. Histological and transcriptional study of angiogenesis and lymphangiogenesis in uninvolved skin, acute pinpoint lesions and established psoriasis plaques: an approach of vascular development chronology in psoriasis. Henno A, etal., J Dermatol Sci. 2010 Mar;57(3):162-9. doi: 10.1016/j.jdermsci.2009.12.006. Epub 2010 Jan 7.
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158. Lipocortin V may function as a signaling protein for vascular endothelial growth factor receptor-2/Flk-1. Wen Y, etal., Biochem Biophys Res Commun. 1999 May 19;258(3):713-21.
159. Two functional forms of vascular endothelial growth factor receptor-2/Flk-1 mRNA are expressed in normal rat retina. Wen Y, etal., J Biol Chem 1998 Jan 23;273(4):2090-7.
160. Inhibition of platelet-derived growth factor promotes pericyte loss and angiogenesis in ischemic retinopathy. Wilkinson-Berka JL, etal., Am J Pathol. 2004 Apr;164(4):1263-73.
161. Induction of angiogenesis and modulation of vascular endothelial growth factor receptor-2 by simvastatin after traumatic brain injury. Wu H, etal., Neurosurgery. 2011 May;68(5):1363-71; discussion 1371.
162. Association between polymorphisms in cancer-related genes and early onset of esophageal adenocarcinoma. Wu IC, etal., Neoplasia. 2011 Apr;13(4):386-92. doi: 10.1593/neo.101722.
163. Expression and significance of vascular endothelial growth factor receptor 2 in bladder cancer. Xia G, etal., J Urol. 2006 Apr;175(4):1245-52.
164. A new selective vascular endothelial growth factor receptor 2 inhibitor ablates disease in a mouse model of psoriasis. Yan HX, etal., Mol Med Rep. 2013 Aug;8(2):434-8. doi: 10.3892/mmr.2013.1500. Epub 2013 May 31.
165. Increased VEGFR-2 gene copy is associated with chemoresistance and shorter survival in patients with non-small-cell lung carcinoma who receive adjuvant chemotherapy. Yang F, etal., Cancer Res. 2011 Aug 15;71(16):5512-21. doi: 10.1158/0008-5472.CAN-10-2614. Epub 2011 Jul 1.
166. Expression and significance of the vascular permeability factor in nasal polyps. Yang J, etal., Chin Med J (Engl). 2002 Aug;115(8):1251-2.
167. Hydrodynamics-based gene delivery of naked DNA encoding fetal liver kinase-1 gene effectively suppresses the growth of pre-existing tumors. Yazawa H, etal., Cancer Gene Ther. 2006 Nov;13(11):993-1001. doi: 10.1038/sj.cgt.7700970. Epub 2006 Jun 9.
168. Non-viral delivery of interleukin-2 and soluble Flk-1 inhibits metastatic and primary tumor growth in renal cell carcinoma. Yockman JW, etal., Gene Ther. 2007 Oct;14(19):1399-405. Epub 2007 Jul 26.
169. Increased expression of tissue vascular endothelial growth factor and foetal liver kinase-1 receptor in seasonal allergic rhinitis and relevance to asthma component. Yuksel H, etal., Clin Exp Allergy. 2007 Aug;37(8):1183-8.
170. Two isoforms of flk-1 transcripts in early diabetic rat retinas. Zhang X, etal., Curr Eye Res. 2012 Jan;37(1):73-9. Epub 2011 Nov 28.
171. Extracellular domain of kinase domain region mediated by adeno-associated virus inhibits growth and angiogenesis of bladder cancer in Balb-c mice. Zhang Z, etal., Chin Med J (Engl). 2002 Aug;115(8):1209-12.
172. The relationship of kinase insert domain receptor gene polymorphisms and clinical outcome in advanced hepatocellular carcinoma patients treated with sorafenib. Zheng YB, etal., Med Oncol. 2014 Oct;31(10):209. doi: 10.1007/s12032-014-0209-z. Epub 2014 Sep 3.
173. The VEGFR-2 protein and the VEGFR-2 rs1870377 A>T genetic polymorphism are prognostic factors for gastric cancer. Zhu X, etal., Cancer Biol Ther. 2019;20(4):497-504. doi: 10.1080/15384047.2018.1537575. Epub 2018 Oct 31.
174. Peritumoral Neuropilin-1 and VEGF receptor-2 expression increases time to recurrence in hepatocellular carcinoma patients undergoing curative hepatectomy. Zhuang PY, etal., Oncotarget. 2014 Nov 30;5(22):11121-32. doi: 10.18632/oncotarget.2553.
175. Orally administered DNA vaccine delivery by attenuated Salmonella typhimurium targeting fetal liver kinase 1 inhibits murine Lewis lung carcinoma growth and metastasis. Zuo SG, etal., Biol Pharm Bull. 2010;33(2):174-82. doi: 10.1248/bpb.33.174.
Additional References at PubMed
PMID:1323289   PMID:1417831   PMID:7596435   PMID:7681362   PMID:7929439   PMID:7999104   PMID:8356051   PMID:9398617   PMID:9804796   PMID:9837777   PMID:10022831   PMID:10037737  
PMID:10102632   PMID:10600473   PMID:10705382   PMID:10878616   PMID:11387210   PMID:11950700   PMID:11967019   PMID:12053176   PMID:12477932   PMID:12569129   PMID:12631117   PMID:12753865  
PMID:12820653   PMID:12897140   PMID:12923895   PMID:14766216   PMID:15215251   PMID:15548727   PMID:15601856   PMID:15644447   PMID:15734877   PMID:15919309   PMID:15962004   PMID:16010973  
PMID:16099728   PMID:16375885   PMID:16455951   PMID:16901919   PMID:16944045   PMID:17050862   PMID:17293873   PMID:17418870   PMID:17651752   PMID:17854994   PMID:17889862   PMID:18174522  
PMID:18321563   PMID:18421240   PMID:18462699   PMID:18482723   PMID:18586890   PMID:18772315   PMID:18835919   PMID:18977327   PMID:19033661   PMID:19357264   PMID:19426150   PMID:19513111  
PMID:19575935   PMID:19635461   PMID:19774558   PMID:20080685   PMID:20103598   PMID:20116868   PMID:20228271   PMID:20406889   PMID:20439428   PMID:20497492   PMID:20550877   PMID:20572782  
PMID:20599605   PMID:20637183   PMID:20660291   PMID:20697002   PMID:21418372   PMID:21435466   PMID:21613481   PMID:21885851   PMID:21928073   PMID:22245234   PMID:22265737   PMID:22499991  
PMID:22569153   PMID:22886301   PMID:22949406   PMID:23262137   PMID:23348691   PMID:23456363   PMID:23529610   PMID:23639442   PMID:23684887   PMID:23688497   PMID:23732519   PMID:23798385  
PMID:23826635   PMID:23831211   PMID:24022223   PMID:24063000   PMID:24205206   PMID:24398936   PMID:24623966   PMID:24630601   PMID:24863063   PMID:25195697   PMID:25730004   PMID:25754303  
PMID:25893857   PMID:26509169   PMID:26879375   PMID:27439004   PMID:27733124   PMID:28457321   PMID:28637396   PMID:28958753   PMID:29710417   PMID:30816491   PMID:30873824   PMID:31406128  
PMID:31583245   PMID:32189115   PMID:32481647   PMID:32918705   PMID:33008083   PMID:33671638   PMID:33904385   PMID:34169992  


Genomics

Comparative Map Data
Kdr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81432,572,031 - 32,615,204 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1432,572,049 - 32,615,192 (+)EnsemblGRCr8
mRatBN7.21432,217,871 - 32,261,018 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1432,217,871 - 32,261,018 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1432,577,934 - 32,621,098 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01433,885,873 - 33,929,041 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01432,370,973 - 32,414,143 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01434,727,677 - 34,787,127 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1434,727,623 - 34,787,183 (+)Ensemblrn6Rnor6.0
Rnor_5.01434,557,361 - 34,618,112 (+)NCBIRnor_5.0Rnor_5.0rn5
Celera1431,512,534 - 31,554,989 (+)NCBICelera
Cytogenetic Map14p11NCBI
KDR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38455,078,481 - 55,125,595 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl455,078,476 - 55,125,595 (-)Ensemblhg38GRCh38
GRCh37455,944,648 - 55,991,762 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36455,639,406 - 55,686,519 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34455,785,576 - 55,832,690NCBI
Celera453,446,341 - 53,493,673 (-)NCBICelera
Cytogenetic Map4q12NCBI
HuRef451,893,013 - 51,940,346 (-)NCBIHuRef
CHM1_1455,979,683 - 56,027,015 (-)NCBICHM1_1
T2T-CHM13v2.0458,566,962 - 58,614,067 (-)NCBIT2T-CHM13v2.0
Kdr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39576,093,487 - 76,139,880 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl576,093,487 - 76,139,118 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38575,932,827 - 75,979,072 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl575,932,827 - 75,978,458 (-)Ensemblmm10GRCm38
MGSCv37576,329,290 - 76,374,453 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36576,214,962 - 76,260,125 (-)NCBIMGSCv36mm8
Celera573,218,468 - 73,263,674 (-)NCBICelera
Cytogenetic Map5C3.3NCBI
cM Map540.23NCBI
Kdr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544715,810,815 - 15,853,583 (+)Ensembl
ChiLan1.0NW_00495544715,810,816 - 15,851,702 (+)NCBIChiLan1.0ChiLan1.0
KDR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2374,668,536 - 74,715,699 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1474,872,484 - 74,922,704 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0468,813,894 - 68,861,018 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1475,377,847 - 75,424,927 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl475,377,375 - 75,427,109 (+)EnsemblpanPan2panpan1.1
KDR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11347,442,861 - 47,484,574 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1347,442,764 - 47,485,042 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1347,400,610 - 47,442,293 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01348,053,730 - 48,095,387 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1348,053,595 - 48,095,437 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11347,729,487 - 47,771,112 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01347,258,117 - 47,299,735 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01348,206,381 - 48,248,022 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Kdr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528528,716,920 - 28,760,830 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648217,538,864 - 17,581,002 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648217,537,697 - 17,581,320 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KDR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl841,809,122 - 41,856,336 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1841,809,116 - 41,856,379 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2843,919,330 - 43,966,984 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KDR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1713,435,059 - 13,482,236 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl713,435,096 - 13,482,771 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606614,207,326 - 14,254,753 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kdr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476114,330,489 - 14,379,051 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462476114,330,224 - 14,380,680 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Kdr
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11132,697,838 - 32,740,235 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Kdr
225 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:764
Count of miRNA genes:299
Interacting mature miRNAs:387
Transcripts:ENSRNOT00000071405
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631528Scl11Serum cholesterol level QTL 114.9blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)141787564536079022Rat
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14140068101Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14140068101Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14939329839411170Rat
1300154Bp189Blood pressure QTL 1893.04arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)143123808072970315Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143067446985041098Rat
2324617Coatc2Coat color QTL 20.001coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)143112133339507682Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14862139853621398Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141891545442433608Rat
7387267Uae42Urinary albumin excretion QTL 420.61urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)142252151767521517Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141889519263895192Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141790672654251504Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141415516Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14862139853621398Rat

Markers in Region
RH128586  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21432,260,625 - 32,260,844 (+)MAPPERmRatBN7.2
Rnor_6.01434,786,739 - 34,786,957NCBIRnor6.0
Rnor_5.01434,617,724 - 34,617,942UniSTSRnor5.0
Celera1431,554,601 - 31,554,819UniSTS
RH 3.4 Map14431.29UniSTS
RH94641  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21432,260,812 - 32,260,983 (+)MAPPERmRatBN7.2
Rnor_6.01434,786,926 - 34,787,096NCBIRnor6.0
Rnor_5.01434,617,911 - 34,618,081UniSTSRnor5.0
Celera1431,554,788 - 31,554,958UniSTS
AU048544  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21432,234,079 - 32,234,343 (+)MAPPERmRatBN7.2
Rnor_6.01434,743,872 - 34,744,135NCBIRnor6.0
Rnor_5.01434,573,535 - 34,573,798UniSTSRnor5.0
Celera1431,528,517 - 31,528,780UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 90 59 6 354 190 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000071405   ⟹   ENSRNOP00000066886
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1432,572,049 - 32,615,192 (+)Ensembl
mRatBN7.2 Ensembl1432,217,871 - 32,261,018 (+)Ensembl
Rnor_6.0 Ensembl1434,727,623 - 34,787,183 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000085089   ⟹   ENSRNOP00000071349
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1432,222,596 - 32,261,018 (+)Ensembl
Rnor_6.0 Ensembl1434,727,915 - 34,785,518 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090183   ⟹   ENSRNOP00000069697
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1434,727,677 - 34,787,124 (+)Ensembl
RefSeq Acc Id: NM_013062   ⟹   NP_037194
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81432,572,063 - 32,615,204 (+)NCBI
mRatBN7.21432,217,871 - 32,261,018 (+)NCBI
Rnor_6.01434,727,677 - 34,787,127 (+)NCBI
Rnor_5.01434,557,361 - 34,618,112 (+)NCBI
Celera1431,512,534 - 31,554,989 (+)RGD
Sequence:
RefSeq Acc Id: XM_063272878   ⟹   XP_063128948
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81432,572,031 - 32,613,492 (+)NCBI
RefSeq Acc Id: NP_037194   ⟸   NM_013062
- Peptide Label: precursor
- UniProtKB: O08775 (UniProtKB/Swiss-Prot),   M0RBF2 (UniProtKB/TrEMBL),   A0A9K3Y7B7 (UniProtKB/TrEMBL),   Q5PQU0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069697   ⟸   ENSRNOT00000090183
Ensembl Acc Id: ENSRNOP00000071349   ⟸   ENSRNOT00000085089
Ensembl Acc Id: ENSRNOP00000066886   ⟸   ENSRNOT00000071405
RefSeq Acc Id: XP_063128948   ⟸   XM_063272878
- Peptide Label: isoform X1
- UniProtKB: O08775 (UniProtKB/Swiss-Prot)
Protein Domains
Ig-like   Ig-like C2-type   Protein kinase   VEGFR1-3 N-terminal Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O08775-F1-model_v2 AlphaFold O08775 1-1343 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699278
Promoter ID:EPDNEW_R9803
Type:single initiation site
Name:Kdr_1
Description:kinase insert domain receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9804  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01434,727,648 - 34,727,708EPDNEW
RGD ID:13699284
Promoter ID:EPDNEW_R9804
Type:single initiation site
Name:Kdr_2
Description:kinase insert domain receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9803  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01434,727,925 - 34,727,985EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2965 AgrOrtholog
BioCyc Gene G2FUF-15933 BioCyc
Ensembl Genes ENSRNOG00000046829 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000071405 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7124961 IMAGE-MGC_LOAD
InterPro Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_I-set UniProtKB/Swiss-Prot
  Ig_sub UniProtKB/Swiss-Prot
  Ig_sub2 UniProtKB/Swiss-Prot
  Immunoglobulin UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  RTK UniProtKB/Swiss-Prot
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Tyr_kinase_AS UniProtKB/Swiss-Prot
  Tyr_kinase_cat_dom UniProtKB/Swiss-Prot
  Tyr_kinase_rcpt_3_CS UniProtKB/Swiss-Prot
  VEGFR-2_TMD UniProtKB/Swiss-Prot
  VEGFR1-3_5th UniProtKB/Swiss-Prot
  VEGFR1-3_N_Ig-like UniProtKB/Swiss-Prot
  VEGFR2_rcpt UniProtKB/Swiss-Prot
KEGG Report rno:25589 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93590 IMAGE-MGC_LOAD
NCBI Gene 25589 ENTREZGENE
PANTHER TYROSINE-PROTEIN KINASE RECEPTOR UniProtKB/Swiss-Prot
  VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 UniProtKB/Swiss-Prot
Pfam I-set UniProtKB/Swiss-Prot
  Ig_3 UniProtKB/Swiss-Prot
  PF00047 UniProtKB/Swiss-Prot
  Pkinase_Tyr UniProtKB/Swiss-Prot
  VEGFR-1-like_5th UniProtKB/Swiss-Prot
  VEGFR-1-like_Ig-like UniProtKB/Swiss-Prot
  VEGFR-2_TMD UniProtKB/Swiss-Prot
  VEGFR1-3_N_Ig-like UniProtKB/Swiss-Prot
PharmGKB KDR RGD
PhenoGen Kdr PhenoGen
PIRSF TyrPK_CSF1-R UniProtKB/Swiss-Prot
PRINTS VEGFRECEPTOR UniProtKB/Swiss-Prot
  VEGFRECEPTR2 UniProtKB/Swiss-Prot
PROSITE IG_LIKE UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_TYR UniProtKB/Swiss-Prot
  RECEPTOR_TYR_KIN_III UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000046829 RatGTEx
SMART IGc2 UniProtKB/Swiss-Prot
  SM00409 UniProtKB/Swiss-Prot
  TyrKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
  SSF56112 UniProtKB/Swiss-Prot
TIGR TC230153
UniProt A0A9K3Y7B7 ENTREZGENE, UniProtKB/TrEMBL
  A6JCZ2_RAT UniProtKB/TrEMBL
  A6JCZ4_RAT UniProtKB/TrEMBL
  M0RBF2 ENTREZGENE
  O08775 ENTREZGENE
  Q5PQU0 ENTREZGENE, UniProtKB/TrEMBL
  VGFR2_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-12-15 Kdr  kinase insert domain receptor  Kdr  kinase insert domain protein receptor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Kdr  kinase insert domain protein receptor    FLK1 kinase insert domain receptor (VEGF receptor 2)  Name updated 625702 APPROVED
2002-06-10 Kdr  FLK1 kinase insert domain receptor (VEGF receptor 2)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in retina 729081
gene_process mediates initiation of vascular growth by angiogenic sprouting; plays a role in endothelial cell proliferation, differentiation, and microvascular permeability 625690
gene_process activation induces vascular permeability 729115