AXITINIB PHARMACODYNAMICS PATHWAY (PW:0001125)

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Description

Axitinib is a selective inhibitor of vascular endothelial growth factor (VEGF) signaling pathway used in the treatment of renal cell carcinoma and several other tumors. The drug belongs to a class of tyrosine kinase receptor inhibitors (TKI) designed to compete with ATP for binding into the ATP binding pocket of the receptor, thus inhibiting its kinase activity and the signaling events downstream of it. Axitinib is selective for VEGF receptor1, 2 and 3; it can also act as a weaker inhibitor for

Pathway Diagram:

Ariadne Genomics Inc. renal cell carcinoma pathway Carcinoma, Renal Cell Flt4 ---| vascular endothelial growth factor signaling pathway Kdr ---| vascular endothelial growth factor signaling pathway Flt1 ---| vascular endothelial growth factor signaling pathway axitinib ---- Flt1 axitinib ---- Kdr axitinib ---- Flt4 Flt1 Kdr ATP ---| Flt1 ATP ---| Kdr ATP Flt4 ATP ---| Flt4 vascular endothelial growth factor signaling pathway ---| renal cell carcinoma pathway vascular endothelial growth factor signaling pathway ---| Carcinoma, Renal Cell vascular endothelial growth factor signaling pathway axitinib
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Genes in Pathway:

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axitinib pharmacodynamics pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Flt1 FMS-related tyrosine kinase 1 JBrowse link 12 9,033,993 9,205,886 RGD:6907361
G Flt4 fms-related tyrosine kinase 4 JBrowse link 10 35,078,782 35,120,296 RGD:6907361
G Kdr kinase insert domain receptor JBrowse link 14 34,727,677 34,787,127 RGD:6907361

Pathway Gene Annotations

Pathway Annotations Associated with Genes in the axitinib pharmacodynamics pathway
Phenotype Annotations Associated with Genes in the axitinib pharmacodynamics pathway

References Associated with the axitinib pharmacodynamics pathway:

Ontology Path Diagram:

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