RGD Reference Report - Expression pattern of VEGFR-1, -2, -3 and D2-40 protein in the skin of patients with systemic sclerosis. - Rat Genome Database

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Expression pattern of VEGFR-1, -2, -3 and D2-40 protein in the skin of patients with systemic sclerosis.

Authors: Higashi-Kuwata, N  Makino, T  Inoue, Y  Ihn, H 
Citation: Higashi-Kuwata N, etal., Eur J Dermatol. 2011 Jul-Aug;21(4):490-4. doi: 10.1684/ejd.2011.1284.
RGD ID: 8552335
Pubmed: PMID:21865112   (View Abstract at PubMed)
DOI: DOI:10.1684/ejd.2011.1284   (Journal Full-text)

The earliest clinical symptoms of systemic sclerosis (SSc) relate to disturbances in the peripheral vascular system. However, detailed examination of the microcirculation including the lymphatics in the skin of patients with SSc has not been reported. The aim of our study was to examine the expression patterns of vascular endothelial growth factor receptor (VEGFR)-1, VEGFR-2, VEGFR-3 and the lymphatic endothelial cell marker D2-40 in the skin of SSc patients. Skin biopsy specimens from nine patients with SSc were analysed by immunohistochemistry using antibodies against VEGFR-1, VEGFR-2, VEGFR-3 and D2-40 protein. The lumen area of lymphatic vessels was measured. The data were statistically analysed using the Mann-Whitney U test, Wilcoxon signed-ranks or Spearman's rank correlation coefficient method. The intensity of VEGFR-2 and VEGFR-3 staining in the skin of patients with SSc was significantly higher than that in healthy controls. The lumen area of lymphatic vessels in the skin of patients with SSc was significantly larger than that in healthy controls. This study details the expression of VEGFR and D2-40 in the skin of patients with SSc, and highlights a possible role of microcirculatory dysfunction in the pathogenesis of systemic sclerosis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
systemic scleroderma  IEP 8552335; 8552335protein:increased expression:skin:RGD 
systemic scleroderma  ISOFLT4 (Homo sapiens)8552335; 8552335protein:increased expression:skin:RGD 
systemic scleroderma  ISOKDR (Homo sapiens)8552335; 8552335protein:increased expression:skin:RGD 

Objects Annotated

Genes (Rattus norvegicus)
Flt4  (Fms related receptor tyrosine kinase 4)
Kdr  (kinase insert domain receptor)

Genes (Mus musculus)
Flt4  (FMS-like tyrosine kinase 4)
Kdr  (kinase insert domain protein receptor)

Genes (Homo sapiens)
FLT4  (fms related receptor tyrosine kinase 4)
KDR  (kinase insert domain receptor)


Additional Information