RGD Reference Report - Differential effects of selective endothelin type a receptor antagonist on the gene expression of vascular endothelial growth factor and its receptors in streptozotocin-induced diabetic heart. - Rat Genome Database

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Differential effects of selective endothelin type a receptor antagonist on the gene expression of vascular endothelial growth factor and its receptors in streptozotocin-induced diabetic heart.

Authors: Jesmin, S  Zaedi, S  Yamaguchi, N  Maeda, S  Shimojo, N  Masuzawa, K  Yamaguchi, I  Goto, K  Miyauchi, T 
Citation: Jesmin S, etal., Exp Biol Med (Maywood). 2006 Jun;231(6):902-6.
RGD ID: 2313724
Pubmed: PMID:16741021   (View Abstract at PubMed)

Cardiovascular complications are an important feature of diabetes mellitus (DM). Abnormal and decreased coronary collateral development has been implicated in the pathogenesis of cardiac complications in DM. More recently, decreased expression of vascular endothelial growth factor (VEGF) and its receptors has been found in diabetic heart. To our knowledge, no study has focused on the therapeutic improvement associated with VEGF in diabetic heart. DM was induced by intraperitoneal injection of streptozotocin (65 mg/kg) in Sprague-Dawley rats, while control rats received only citrate buffer. After 1 week, the streptozotocin-treated rats were randomly divided into two groups: one group received the selective endothelin (ET) type A receptor antagonist TA-0201 at a dose of 1 mg/kg/day for 2 weeks by osmotic mini-pump, and the vehicle group received saline only. The plasma glucose level was 504 +/- 75 mg/dl in the diabetic rats and was unchanged by treatment with ET antagonist. The body weight was decreased in the diabetic rats compared with the control rats, but the left ventricular (LV)-body weight ratio was increased in the diabetic group and was unaffected by treatment with ET antagonist. mRNA expression of VEGF and its receptors (Flt-1 and Flk-1) in the LV tissues was assessed using real-time polymerase chain reaction. VEGF expression was significantly decreased in diabetic heart and was greatly improved by treatment with ET antagonist. The expression of VEGF receptors was down-regulated in early diabetic heart but was not recovered by treatment with ET antagonist. ET and its receptor A might have differential regulation on the gene expressions of VEGF and its receptors in early diabetic heart.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Experimental Diabetes Mellitus  ISOFlt1 (Rattus norvegicus)2313724; 2313724mRNA:decreased expression:heartRGD 
Experimental Diabetes Mellitus  IEP 2313724; 2313724; 2313724mRNA:decreased expression:heartRGD 
Experimental Diabetes Mellitus  ISOKdr (Rattus norvegicus)2313724; 2313724mRNA:decreased expression:heartRGD 
Experimental Diabetes Mellitus  ISOVegfa (Rattus norvegicus)2313724; 2313724mRNA:decreased expression:heartRGD 

Objects Annotated

Genes (Rattus norvegicus)
Flt1  (Fms related receptor tyrosine kinase 1)
Kdr  (kinase insert domain receptor)
Vegfa  (vascular endothelial growth factor A)

Genes (Mus musculus)
Flt1  (FMS-like tyrosine kinase 1)
Kdr  (kinase insert domain protein receptor)
Vegfa  (vascular endothelial growth factor A)

Genes (Homo sapiens)
FLT1  (fms related receptor tyrosine kinase 1)
KDR  (kinase insert domain receptor)
VEGFA  (vascular endothelial growth factor A)


Additional Information