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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2965
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kdr
Name: kinase insert domain receptor
Acc ID: CHEBI:3962
Term: curcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
Chemical ID: MESH:D003474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kdrmultiple interactionsEXP 6480464CTDCurcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of KDR mRNA]; Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of KDR protein]PMID:23845850
Kdraffects expressionISOKDR (Homo sapiens)6480464CTDCurcumin affects the expression of KDR mRNAPMID:17960570
Kdrmultiple interactionsISOKdr (Mus musculus)6480464CTDCurcumin inhibits the reaction [Dietary Fats results in increased expression of KDR mRNA]PMID:19297423
Kdrmultiple interactionsISOKDR (Homo sapiens)6480464CTD[bisdemethoxycurcumin co-treated with Curcumin co-treated with demethoxycurcumin] inhibits the reaction [VEGF protein results in increased phosphorylation of KDR protein]; Curcumin inhibits the reaction [VEGF protein results in increased phosphorylation of KDR protein]PMID:35752269
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