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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2965
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kdr
Name: kinase insert domain receptor
Acc ID: CHEBI:9288
Term: streptozocin
Definition: An N-nitrosourea that is an antibiotic produced by Streptomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.
Chemical ID: MESH:D013311
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kdrincreases expressionEXP 6480464CTDStreptozocin results in increased expression of KDR mRNA; Streptozocin results in increased expression of KDR proteinPMID:15643138 PMID:20821229
Kdrmultiple interactionsEXP 6480464CTDSimvastatin inhibits the reaction [Streptozocin results in increased expression of KDR mRNA]; Simvastatin inhibits the reaction [Streptozocin results in increased phosphorylation of and results in increased expression of KDR protein]; Streptozocin results in increased phosphorylation of and results in increased expression of KDR proteinPMID:20821229
Kdrmultiple interactionsISOKdr (Mus musculus)6480464CTD[Dietary Fats co-treated with Streptozocin] results in increased expression of KDR protein; Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of KDR protein]; sarpogrelate inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of KDR protein]PMID:27097221
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