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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2965
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kdr
Name: kinase insert domain receptor
Acc ID: CHEBI:91088
Term: orantinib
Definition: An oxindole that is 3-methyleneoxindole in which one of the hydrogens of the methylene group is substituted by a 2-(2-carboxyethyl)-3,5-dimethylpyrrol-3-yl group. It is an ATP-competitive inhibitor of the tyrosine kinase activity of fibroblast growth factor receptor 1.
Chemical ID: MESH:C412603
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kdrmultiple interactionsISOKDR (Homo sapiens)6480464CTDorantinib results in decreased phosphorylation of and results in decreased activity of KDR proteinPMID:16144927
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