Gene:	Mapk9 ( Rattus norvegicus ) mitogen-activated protein kinase 9
Description:	an enzyme exhibiting JUN kinase activity, mitogen-activated protein kinase kinase kinase binding, caspase activator activity and other functions; involved in positive regulation of cell morphogenesis involved in differentiation, regulation of JNK cascade, positive regulation of apoptosis and other processes; found in cytoplasm, mitochondrion, nucleus; associated with Precancerous Conditions (liver), Arteriosclerosis (mouse ortholog); associated with abnormal apoptosis, prenatal lethality; part of c-Jun N-terminal kinases MAPK signaling pathway, mitogen activated protein kinase signaling pathway, Wnt signaling pathway and other pathways
Synonyms:	SAPK; stress activated protein kinase alpha II;  (details...)
ArrayIDs:	6325712; rc_AI231354_g_at; 5898774; 5840280; 6674645; rc_AI231354_at; 6175318; 1380024_at; 5627784; L27112_s_at; 5842935; 5661468; A_44_P217423; 6027032; GE20498; GE21714; 1368646_at; 6124790; 6526206; 5687084; A_43_P11915; A_44_P480222; 5749596; 6064147; 6610571; 6617292; 6232690; 5962627; 6252184; 6245850; 6391575; A_44_P451014; 5852933; 6429529;  (details...)
Gene Type:	protein-coding
Additional Data
Candidate gene for:	Eau7 - Experimental allergic uveoretinitis QTL 7
Homologs
Homo sapiens: MAPK9     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Mapk9     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Mapk9 Rat Celera Assembly 10 33534199 - 33565031     RGSC genome assembly v3.4 10 35353486 - 35384319     Cytogenetic 10 q22     genome assembly 3.1 10 35354534 - 35385368 Mus musculus Mapk9 Mouse genome assembly build 36.1 11 49660256 - 49699600     Cytogenetic 11 11 B1.2 Homo sapiens MAPK9 human genome assembly 5 179595389 - 179640216     Human genome assembly build 36.2 5 179595390 - 179640216     Cytogenetic 5 q35   View comparative maps:      NCBI MapViewer
Genome
View:
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Annotation
Molecular Function	Gene Ontology JUN kinase activity,  protein binding,  caspase activator activity ...  (details...)
Biological Process	Note Reference activation has a role in the initiation of PC12 cell death 729126 Gene Ontology positive regulation of cell morphogenesis involved in differentiation,  response to lipopolysaccharide,  positive regulation of nitric oxide biosynthetic process ...  (details...)
Cellular Component	Gene Ontology nucleus,  mitochondrion,  cytoplasm (details...)
Disease	Ontology Precancerous Conditions,  Arteriosclerosis (details...)
Phenotype	Ontology prenatal lethality,  abnormal apoptosis (details...)
Pathway	Ontology mitogen activated protein kinase signaling pathway,  c-Jun N-terminal kinases MAPK signaling pathway,  Wnt signaling pathway ...  (details...)
External Links
Databases	DATABASE ID SOURCE SMART: S_TKc IPI PROSITE: MAPK IPI PROSITE: PROTEIN_KINASE_ST IPI PROSITE: PROTEIN_KINASE_DOM IPI UNIPARC: UPI0000000174 IPI UNIPARC: UPI000002AE10 IPI UNIPARC: UPI000002AE0F IPI KEGG Report: rno:50658 ENTREZGENE HomoloGene Group ID: 55685 ENTREZGENE Germonline: 628847 Pfam: Pkinase IPI KEGG Pathway: 04310 ENTREZGENE KEGG Pathway: 04930 ENTREZGENE KEGG Pathway: 04620 ENTREZGENE KEGG Pathway: 05212 ENTREZGENE KEGG Pathway: 04010 ENTREZGENE KEGG Pathway: 04910 ENTREZGENE KEGG Pathway: 04912 ENTREZGENE KEGG Pathway: 04510 ENTREZGENE KEGG Pathway: 04664 ENTREZGENE KEGG Pathway: 04012 ENTREZGENE KEGG Pathway: 05210 ENTREZGENE KEGG Pathway: 04920 ENTREZGENE InterPro: JNK_MAPK. IPI InterPro: MAP_kinase_CS. IPI InterPro: Se/Thr_prot_kinase-like_dom. IPI InterPro: Ser/Thr_prot_kinase_dom. IPI InterPro: Ser/Thr_prot_kinase_AS. IPI InterPro: Kinase-like_dom. IPI InterPro: Prot_kinase_cat_dom. IPI Ensembl Protein: ENSRNOP00000039660 IPI Ensembl Protein: ENSRNOP00000004010 IPI Ensembl Protein: ENSRNOP00000003987 IPI IPI: IPI00231634 IPI IPI: IPI00191806 IPI IPI: IPI00948485 IPI Entrez Gene: Mapk9 ENTREZGENE IMAGE_CLONE: IMAGE:5598943 IMAGE-MGC_LOAD MGC_CLONE: MGC:72494 IMAGE-MGC_LOAD UniProt: Q6P727_RAT IPI UniProt: MK09_RAT IPI UniProt: MK09_RAT IPI Ensembl Genes: ENSRNOG00000002823 IPI Superfamily-SCOP: Kinase_like IPI PRINTS: JNKMAPKINASE. IPI
Sequences	Nucleotide: CH473948 Get FASTA Search GEO Profiles Nucleotide: BC061870 Get FASTA Search GEO Profiles Nucleotide: NM_017322 Get FASTA Search GEO Profiles Nucleotide: L27111 Get FASTA Search GEO Profiles Nucleotide: L27112 Get FASTA Search GEO Profiles (View all 5 Nucleotide Accessions) Protein: AAH61870 Get FASTA Protein: AAA42108 Get FASTA Protein: AAA42109 Get FASTA Protein: P49186 Get FASTA Protein: Q6P727 Get FASTA Protein: NP_059018 Get FASTA Protein: EDM04242 Get FASTA Protein: EDM04241 Get FASTA Protein: EDM04240 Get FASTA Protein: EDM04239 Get FASTA Protein: EDM04237 Get FASTA Protein: EDM04238 Get FASTA (View all 12 Protein Accessions)
Clusters	UniGene: 9910
References
Curated References	25 references in RGD related to Mapk9
Other References	31 other references at PubMed related to Mapk9
Database Information
RGD ID	628847
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 14-DEC-04: Mapk9 mitogen-activated protein kinase 9 stress activated protein kinase alpha II APPROVED Name updated 1299863 27-FEB-03: Mapk9 stress activated protein kinase alpha II PROVISIONAL Symbol and Name status set to provisional 70820