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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628847
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk9
Name: mitogen-activated protein kinase 9
Acc ID: CHEBI:30621
Term: diarsenic trioxide
Definition: An arsenic oxide in which arsenic and oxygen atoms are present in the ratio 2:3.
Chemical ID: MESH:C006632
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk9increases phosphorylationEXP 6480464CTDArsenic Trioxide results in increased phosphorylation of MAPK9 proteinPMID:21145380 PMID:27174766
Mapk9multiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK9 protein]PMID:21145380 PMID:27174766
Mapk9increases activityISOMAPK9 (Homo sapiens)6480464CTDArsenic Trioxide results in increased activity of MAPK9 proteinPMID:12296996
Mapk9increases expressionISOMAPK9 (Homo sapiens)6480464CTDArsenic Trioxide results in increased expression of MAPK9 proteinPMID:17374990
Mapk9increases phosphorylationISOMAPK9 (Homo sapiens)6480464CTDArsenic Trioxide results in increased phosphorylation of MAPK9 proteinPMID:18412143 PMID:24466103
Mapk9increases phosphorylationISOMapk9 (Mus musculus)6480464CTDArsenic Trioxide results in increased phosphorylation of MAPK9 proteinPMID:15688020
Mapk9increases response to substanceISOMAPK9 (Homo sapiens)6480464CTDMAPK9 results in increased susceptibility to Arsenic TrioxidePMID:20799280
Mapk9increases response to substanceISOMapk9 (Mus musculus)6480464CTDMAPK9 protein results in increased susceptibility to Arsenic Trioxide; MAPK9 results in increased susceptibility to Arsenic TrioxidePMID:16818652
Mapk9multiple interactionsISOMAPK9 (Homo sapiens)6480464CTD[Bortezomib co-treated with Arsenic Trioxide] affects the expression of MAPK9 protein; [IL24 protein co-treated with Arsenic Trioxide] results in increased phosphorylation of MAPK9 protein; Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK9 protein]; Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK9 protein; indole-5-carboxamide promotes the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK9 protein]; MAPK8 mutant form inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK9 protein]; MAPK9 mutant form inhibits the reaction [Arsenic Trioxide results in increased activity of CASP3 protein]; MAPK9 mutant form inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of BCL2 protein]; MAPK9 mutant form inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of MAPK9 protein]; SB 203580 promotes the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK9 protein]; SCIO-469 promotes the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK9 protein]PMID:15580305 PMID:16818652 PMID:18412143 PMID:18718063 PMID:20799280
Mapk9multiple interactionsISOMapk9 (Mus musculus)6480464CTD[Arsenic Trioxide results in increased abundance of arsenite] which results in increased phosphorylation of MAPK9 proteinPMID:36791901
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