Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628847
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk9
Name: mitogen-activated protein kinase 9
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk9increases phosphorylationEXP 6480464CTDLipopolysaccharides results in increased phosphorylation of MAPK9 proteinPMID:25557508
Mapk9multiple interactionsEXP 6480464CTDApigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]PMID:25557508
Mapk9increases expressionISOMapk9 (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of MAPK9 mRNA; Lipopolysaccharides results in increased expression of MAPK9 protein; Lipopolysaccharides results in increased expression of MAPK9 protein modified formPMID:15832817 PMID:35833596 PMID:37177863
Mapk9increases phosphorylationISOMAPK9 (Homo sapiens)6480464CTDLipopolysaccharides results in increased phosphorylation of MAPK9 proteinPMID:21911040 PMID:22004089 PMID:24967690 PMID:27129696
Mapk9increases phosphorylationISOMapk9 (Mus musculus)6480464CTDLipopolysaccharides results in increased phosphorylation of MAPK9 proteinPMID:14644621 PMID:16023107 PMID:20023007 PMID:20923188 PMID:21465277 PMID:22060784 PMID:22155741 PMID:25451575 PMID:25451593 PMID:25818598 PMID:27568862 PMID:28906110 PMID:29906494 PMID:32800949 PMID:35616142 PMID:35833596
Mapk9multiple interactionsISOMAPK9 (Homo sapiens)6480464CTD1,6-hexamethylene diisocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]; [Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of MAPK9 protein; acetovanillone inhibits the reaction [[Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of MAPK9 protein]; acetovanillone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]; Acetylcysteine inhibits the reaction [[Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of MAPK9 protein]; CBR1 protein modified form inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]; diphenyleneiodonium inhibits the reaction [[Lipopolysaccharides results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of MAPK9 protein]; DUSP1 mutant form inhibits the reaction [trichostatin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]]; Eucalyptol inhibits the reaction [Lipopolysaccharides results in decreased expression of and results in decreased phosphorylation of MAPK9 protein]; eupafolin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]; Fluorescein-5-isothiocyanate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]; Lipopolysaccharides results in decreased expression of and results in decreased phosphorylation of MAPK9 protein; MAPK9 gene mutant form inhibits the reaction [Lipopolysaccharides promotes the reaction [TGFB1 results in increased expression of PDGFB mRNA]]; phthalic anhydride inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]; trichostatin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]; trimellitic anhydride inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]PMID:21391979 PMID:21911040 PMID:22004089 PMID:23872422 PMID:24967690 PMID:25818598 PMID:27129696
Mapk9multiple interactionsISOMapk9 (Mus musculus)6480464CTD2'-hydroxyflavanone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Lipopolysaccharides promotes the reaction [Polystyrenes results in increased expression of MAPK9 mRNA]]; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Lipopolysaccharides promotes the reaction [Polystyrenes results in increased phosphorylation of MAPK9 protein]]; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Polystyrenes promotes the reaction [Lipopolysaccharides results in increased expression of MAPK9 mRNA]]; [Acetylcysteine results in decreased abundance of Reactive Oxygen Species] inhibits the reaction [Polystyrenes promotes the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]]; [IL10 protein co-treated with Dexamethasone] inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK9 protein]; [Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK9 protein; [TLR4 protein co-treated with TNFRSF1A protein] affects the reaction [IL10 protein inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK9 protein]]; chromium mesoporphyrin inhibits the reaction [MAPK9 protein inhibits the reaction [Lipopolysaccharides results in decreased expression of TNF protein]]; coagulin-L inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]; deoxynivalenol promotes the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK9 protein]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]; ethyl N-allyl-N-(2-methyl-3-(4-(4-amidinophenoxycarbonyl)phenyl)propenoyl)aminoacetate methanesulfonate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]; fucoxanthin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]; GSTP1 protein inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]; HMOX1 protein promotes the reaction [MAPK9 protein inhibits the reaction [Lipopolysaccharides results in decreased expression of TNF protein]]; IL10 protein inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK9 protein]; licochalcone B analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]; Lipopolysaccharides promotes the reaction [Polystyrenes results in increased expression of MAPK9 mRNA]; Lipopolysaccharides promotes the reaction [Polystyrenes results in increased phosphorylation of MAPK9 protein]; MAPK9 protein inhibits the reaction [Lipopolysaccharides results in decreased expression of TNF protein]; Plant Extracts inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]; Plant Oils inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]; Polystyrenes promotes the reaction [Lipopolysaccharides results in increased expression of MAPK9 mRNA]; Polystyrenes promotes the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]; prolinedithiocarbamate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]; Rotenone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]; soyasaponin Ab inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]; tanshinone analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein]; TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of MAPK9 protein]; TLR4 protein affects the reaction [TNFRSF1A protein affects the reaction [Lipopolysaccharides results in increased expression of MAPK9 protein]]; TNFRSF1A protein affects the reaction [Lipopolysaccharides results in increased expression of MAPK9 protein]; TNFRSF1A protein affects the reaction [TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of MAPK9 protein]]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK9 protein]PMID:14644621 PMID:16023107 PMID:19667931 PMID:20023007 PMID:21465277 PMID:22060784 PMID:23362215 PMID:23831309 PMID:25451593 PMID:27568862 PMID:28906110 PMID:29906494 PMID:32800949 PMID:35616142 PMID:35833596 PMID:37177863
Go Back to source page   Continue to Ontology report