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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 628847
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mapk9
Name: mitogen-activated protein kinase 9
Acc ID: CHEBI:37537
Term: phorbol 13-acetate 12-myristate
Definition: A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.
Chemical ID: MESH:D013755
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mapk9increases phosphorylationISOMAPK9 (Homo sapiens)6480464CTDTetradecanoylphorbol Acetate results in increased phosphorylation of MAPK9 proteinPMID:16838270 PMID:19447859 PMID:20599481 PMID:21354279 PMID:22353212 PMID:22561169 PMID:30133131 PMID:30259628
Mapk9increases phosphorylationISOMapk9 (Mus musculus)6480464CTDTetradecanoylphorbol Acetate results in increased phosphorylation of MAPK9 proteinPMID:17693661 PMID:25496033 PMID:25818598
Mapk9multiple interactionsISOMAPK9 (Homo sapiens)6480464CTDCBR1 protein modified form inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK9 protein]; Luteolin analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK9 protein]; Manganese promotes the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK9 protein]; pterostilbene inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK9 protein]; rottlerin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK9 protein]PMID:19447859 PMID:20599481 PMID:22561169 PMID:25818598 PMID:30133131
Mapk9multiple interactionsISOMapk9 (Mus musculus)6480464CTDChenodeoxycholic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK9 protein]; GW 4064 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK9 protein]; myricetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK9 protein]PMID:17693661 PMID:25496033
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