Rps6kb1 (ribosomal protein S6 kinase B1) - Rat Genome Database

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Gene: Rps6kb1 (ribosomal protein S6 kinase B1) Rattus norvegicus
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Symbol: Rps6kb1
Name: ribosomal protein S6 kinase B1
RGD ID: 620683
Description: Enables several functions, including ATP binding activity; PDZ domain binding activity; and protein phosphatase 2A binding activity. Involved in several processes, including long-term memory; positive regulation of skeletal muscle tissue growth; and skeletal muscle atrophy. Located in cell surface and perinuclear region of cytoplasm. Is active in postsynapse. Biomarker of several diseases, including autosomal dominant polycystic kidney disease; hyperinsulinism; muscular atrophy; obesity; and primary biliary cholangitis. Orthologous to human RPS6KB1 (ribosomal protein S6 kinase B1); PARTICIPATES IN mTOR signaling pathway; insulin signaling pathway; insulin-like growth factor signaling pathway; INTERACTS WITH 1-octadec-9-enoylglycero-3-phosphate; 17beta-estradiol; 17beta-hydroxy-5alpha-androstan-3-one.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 70 kDa ribosomal protein S6 kinase 1; p70 ribosomal S6 kinase alpha; p70 S6 kinase alpha; p70 S6K-alpha; p70 S6KA; p70(S6K)-alpha; p70-S6K 1; P70S6K; P70S6K1; ribosomal protein S6 kinase beta-1; ribosomal protein S6 kinase I; ribosomal protein S6 kinase, 70kDa, polypeptide 1; ribosomal protein S6 kinase, polypeptide 1; S6 kinase; S6K; S6K-beta-1; S6K1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Bp309
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81071,817,794 - 71,865,211 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1071,815,614 - 71,865,238 (-)EnsemblGRCr8
mRatBN7.21071,323,777 - 71,367,908 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1071,323,777 - 71,367,908 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1075,946,721 - 75,987,672 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01075,451,529 - 75,492,547 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01070,916,142 - 70,957,095 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01073,824,200 - 73,865,503 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1073,824,202 - 73,865,364 (-)Ensemblrn6Rnor6.0
Rnor_5.01076,234,192 - 76,278,394 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41076,657,024 - 76,698,088 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1070,248,523 - 70,289,589 (-)NCBICelera
RGSC_v3.11076,671,395 - 76,712,458 (-)NCBI
Cytogenetic Map10q26NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(-)-gambogic acid  (ISO)
(S)-nicotine  (ISO)
1,1'-azobis(N,N-dimethylformamide)  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-[4,4-bis(4-fluorophenyl)butyl]-4-[4-chloro-3-(trifluoromethyl)phenyl]-4-piperidinol  (ISO)
1-octadec-9-enoylglycero-3-phosphate  (EXP,ISO)
14,15-EET  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-deoxy-D-glucose  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-bromopyruvic acid  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methyladenine  (EXP,ISO)
3H-1,2-dithiole-3-thione  (EXP)
4'-epidoxorubicin  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-nonylphenol  (EXP)
4-tert-Octylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
9-cis-retinoic acid  (ISO)
acadesine  (ISO)
acetaldehyde  (ISO)
acetylsalicylic acid  (ISO)
aconitine  (EXP)
acrolein  (ISO)
actinomycin D  (ISO)
adenosine  (ISO)
AICA ribonucleotide  (EXP)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
Alisol B  (ISO)
all-trans-retinoic acid  (ISO)
alpha,alpha-trehalose  (ISO)
alpha-(methylamino)isobutyric acid  (ISO)
Alpinetin  (ISO)
alternariol  (ISO)
amino acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP,ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
ANTIMYCIN  (ISO)
apabetalone  (ISO)
apigenin  (ISO)
arachidonic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
atrazine  (ISO)
aucubin  (ISO)
avobenzone  (ISO)
azathioprine  (ISO)
bafilomycin A1  (EXP,ISO)
baicalein  (ISO)
BAPTA  (ISO)
Bardoxolone methyl  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzofurans  (ISO)
beta-D-glucosamine  (ISO)
beta-thujaplicin  (ISO)
bicalutamide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
BMS-754807  (ISO)
bortezomib  (ISO)
bromobenzene  (EXP)
bucladesine  (ISO)
butan-1-ol  (EXP,ISO)
butanal  (ISO)
Butylparaben  (ISO)
C.I. Natural Red 20  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calciol  (ISO)
calcium atom  (EXP,ISO)
calcium(0)  (EXP,ISO)
calyculin A  (EXP)
cannabidiol  (ISO)
cantharidin  (EXP)
capsaicin  (ISO)
carbachol  (ISO)
carbon disulfide  (EXP)
celastrol  (EXP)
chloroquine  (EXP,ISO)
cholesterol  (ISO)
chromium atom  (ISO)
chromium(6+)  (EXP,ISO)
chrysophanol  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
Corynoxine B  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
cucurbitacin E  (EXP,ISO)
curcumin  (ISO)
cycloheximide  (EXP)
cyfluthrin  (EXP,ISO)
cypermethrin  (ISO)
D-glucose  (EXP,ISO)
dactolisib  (ISO)
daunorubicin  (EXP,ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenziodolium  (ISO)
Dictamnine  (ISO)
dieckol  (ISO)
digitoxin  (ISO)
dihydrolipoic acid  (EXP)
Dihydrotanshinone I  (ISO)
dimercaprol  (ISO)
Dinitramine  (ISO)
dioscin  (ISO)
diosgenin  (ISO)
dioxygen  (ISO)
dodecanoic acid  (ISO)
dopamine  (ISO)
dorsomorphin  (EXP,ISO)
doxorubicin  (EXP,ISO)
EHT 1864  (ISO)
enzacamene  (ISO)
erlotinib hydrochloride  (ISO)
ethanol  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (EXP,ISO)
everolimus  (EXP,ISO)
fasudil  (ISO)
fingolimod hydrochloride  (ISO)
flavanones  (ISO)
flavokawain B  (ISO)
flavonoids  (EXP)
flufenoxuron  (ISO)
flutamide  (EXP)
formaldehyde  (ISO)
FR900359  (ISO)
frenolicin B  (ISO)
Fusaric acid  (ISO)
galangin  (ISO)
Gastrodin  (EXP,ISO)
gefitinib  (ISO)
genistein  (ISO)
Gingerenone A  (EXP,ISO)
gingerol  (ISO)
ginsenoside Re  (ISO)
glucose  (EXP,ISO)
glutathione  (EXP)
glycerol 2-phosphate  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
gossypol  (ISO)
hexadecanoic acid  (EXP,ISO)
HU-308  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
IC-87114  (ISO)
indometacin  (EXP)
irinotecan  (ISO)
isoprenaline  (EXP,ISO)
ivermectin  (ISO)
KN-93  (EXP)
L-ascorbic acid 2-phosphate  (ISO)
lead diacetate  (EXP)
lead nitrate  (EXP)
Licochalcone A  (ISO)
Licochalcone B  (ISO)
lithocholic acid  (ISO)
Lobetyolin  (ISO)
lonidamine  (ISO)
LY294002  (EXP,ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP,ISO)
medroxyprogesterone acetate  (ISO)
metformin  (ISO)
methamphetamine  (EXP)
methidathion  (ISO)
methotrexate  (EXP)
methoxyacetic acid  (EXP)
metoprolol  (EXP)
miconazole  (ISO)
microcystin-LR  (EXP,ISO)
MK-2206  (ISO)
ML-7  (EXP,ISO)
mono(2-ethylhexyl) phthalate  (ISO)
morin  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP,ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodimethylamine  (EXP)
naringin  (EXP)
neomycin  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
nicotinic acid  (EXP)
nitric oxide  (ISO)
Nodularin  (EXP)
Nonylphenol  (EXP)
ochratoxin A  (ISO)
okadaic acid  (EXP)
oligopeptide  (ISO)
omipalisib  (ISO)
orotic acid  (ISO)
ouabain  (EXP)
oxybenzone  (ISO)
ozone  (ISO)
p-tert-Amylphenol  (ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
paraquat  (ISO)
Parthenin  (ISO)
PD173074  (ISO)
perfluorooctanoic acid  (EXP)
phenethyl isothiocyanate  (ISO)
phenobarbital  (ISO)
phenylarsine oxide  (ISO)
phenylephrine  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phosphatidic acid  (ISO)
picropodophyllotoxin  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
platycodin D  (ISO)
prazosin  (EXP)
progesterone  (EXP)
propranolol  (ISO)
puerarin  (EXP,ISO)
pyrvinium  (ISO)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
rottlerin  (EXP)
roxarsone  (EXP)
rucaparib  (ISO)
Salidroside  (EXP)
sapanisertib  (ISO)
SB 203580  (ISO)
SB 415286  (ISO)
serpentine asbestos  (ISO)
sertraline  (EXP,ISO)
Shikonin  (ISO)
silicon dioxide  (EXP)
simvastatin  (ISO)
sirolimus  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP,ISO)
Sodium salicylate  (ISO)
sorafenib  (ISO)
stilbenoid  (ISO)
succimer  (ISO)
sulfates  (ISO)
sunitinib  (ISO)
superoxide  (ISO)
swainsonine  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
Tautomycin  (EXP)
Temsirolimus  (ISO)
teriflunomide  (ISO)
testosterone  (ISO)
tetrathiomolybdate(2-)  (ISO)
theobromine  (EXP)
thioacetamide  (ISO)
Thiorphan  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
torin 1  (ISO)
trametinib  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (EXP,ISO)
triclosan  (EXP)
trifluoperazine  (EXP,ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
ursolic acid  (ISO)
usnic acid  (ISO)
valproic acid  (ISO)
vanadium atom  (ISO)
vanadium(0)  (ISO)
warfarin  (ISO)
wortmannin  (EXP,ISO)
zearalenone  (ISO)
zotarolimus  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA)
behavioral fear response  (ISO)
cell migration  (IEP)
cellular response to dexamethasone stimulus  (ISO)
cellular response to growth factor stimulus  (ISO,ISS)
cellular response to hormone stimulus  (IEA,IEP)
cellular response to insulin stimulus  (IBA,ISO)
cellular response to nutrient  (ISO)
cellular response to type II interferon  (ISO)
G1/S transition of mitotic cell cycle  (ISO)
germ cell development  (ISO)
long-chain fatty acid import into cell  (ISO,ISS)
long-term memory  (IEP)
modulation of chemical synaptic transmission  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of extrinsic apoptotic signaling pathway  (ISO)
negative regulation of insulin receptor signaling pathway  (IEA,IMP,ISO)
negative regulation of TORC2 signaling  (ISO,ISS)
peptidyl-serine phosphorylation  (ISO,ISS)
positive regulation of mitotic cell cycle  (ISO)
positive regulation of skeletal muscle tissue growth  (IMP)
positive regulation of smooth muscle cell migration  (IMP)
positive regulation of smooth muscle cell proliferation  (IMP)
positive regulation of TORC1 signaling  (ISO)
positive regulation of translation  (ISO)
positive regulation of translational initiation  (ISO)
protein phosphorylation  (IDA,IMP,ISO)
regulation of D-glucose import across plasma membrane  (IMP)
regulation of kinase activity  (ISO)
regulation of translation  (IEA)
response to amino acid  (IEP)
response to electrical stimulus involved in regulation of muscle adaptation  (IEP)
response to ethanol  (IEP)
response to glucagon  (IEP)
response to glucocorticoid  (IEA,IEP)
response to glucose  (IEP)
response to insulin  (IEA,IEP,IMP)
response to ketone  (IEA)
response to L-leucine  (IEP)
response to lipopolysaccharide  (IEP)
response to mechanical stimulus  (IEP)
response to methamphetamine hydrochloride  (IEP)
response to nutrient  (IEP)
response to nutrient levels  (ISO)
response to other organism  (IEA)
response to peptide hormone  (IEP)
response to testosterone  (IEP)
response to toxic substance  (IEP)
response to tumor necrosis factor  (IMP)
response to xenobiotic stimulus  (IEP)
signal transduction  (IEA)
skeletal muscle atrophy  (IEP)
skeletal muscle contraction  (IEP)
TOR signaling  (ISO,ISS)
TORC1 signaling  (IBA,ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. mTOR pathway inhibition attenuates skeletal muscle growth induced by stretching. Aoki MS, etal., Cell Tissue Res. 2006 Apr;324(1):149-56. Epub 2006 Jan 12.
2. Localization of translational components at the ultramicroscopic level at postsynaptic sites of the rat brain. Asaki C, etal., Brain Res. 2003 May 16;972(1-2):168-76.
3. Selective activation of AMPK-PGC-1alpha or PKB-TSC2-mTOR signaling can explain specific adaptive responses to endurance or resistance training-like electrical muscle stimulation. Atherton PJ, etal., FASEB J. 2005 May;19(7):786-8. Epub 2005 Feb 16.
4. Molecular structure of a major insulin/mitogen-activated 70-kDa S6 protein kinase. Banerjee P, etal., Proc Natl Acad Sci U S A 1990 Nov;87(21):8550-4.
5. Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures. Bernard PB, etal., Neurobiol Dis. 2013 Nov;59:1-17. doi: 10.1016/j.nbd.2013.06.013. Epub 2013 Jul 2.
6. Long-term treatment of bile duct-ligated rats with rapamycin (sirolimus) significantly attenuates liver fibrosis: analysis of the underlying mechanisms. Biecker E, etal., J Pharmacol Exp Ther. 2005 Jun;313(3):952-61. Epub 2005 Mar 15.
7. Prolactin activates mammalian target-of-rapamycin through phosphatidylinositol 3-kinase and stimulates phosphorylation of p70S6K and 4E-binding protein-1 in lymphoma cells. Bishop JD, etal., J Endocrinol. 2006 Aug;190(2):307-12.
8. Ribosomal protein S6 phosphorylation and function during late gestation liver development in the rat. Boylan JM, etal., J Biol Chem. 2001 Nov 30;276(48):44457-63. Epub 2001 Sep 26.
9. Adrenaline potentiates insulin-stimulated PKB activation via cAMP and Epac: implications for cross talk between insulin and adrenaline. Brennesvik EO, etal., Cell Signal. 2005 Dec;17(12):1551-9.
10. Neurabin is a synaptic protein linking p70 S6 kinase and the neuronal cytoskeleton. Burnett PE, etal., Proc Natl Acad Sci U S A. 1998 Jul 7;95(14):8351-6.
11. Time-restricted role for dendritic activation of the mTOR-p70S6K pathway in the induction of late-phase long-term potentiation in the CA1. Cammalleri M, etal., Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14368-73. doi: 10.1073/pnas.2336098100. Epub 2003 Nov 17.
12. Thrombin induces expression of FGF-2 via activation of PI3K-Akt-Fra-1 signaling axis leading to DNA synthesis and motility in vascular smooth muscle cells. Cao H, etal., Am J Physiol Cell Physiol. 2006 Jan;290(1):C172-82. Epub 2005 Sep 7.
13. Spatial memory formation and memory-enhancing effect of glucose involves activation of the tuberous sclerosis complex-Mammalian target of rapamycin pathway. Dash PK, etal., J Neurosci. 2006 Aug 2;26(31):8048-56.
14. Chronic paraplegia-induced muscle atrophy downregulates the mTOR/S6K1 signaling pathway. Dreyer HC, etal., J Appl Physiol. 2007 Sep 20;.
15. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
16. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
17. Disparate regulation of signaling proteins after exercise and myocardial infarction. Gosselin H, etal., Med Sci Sports Exerc. 2006 Mar;38(3):455-62.
18. Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Hara K, etal., Cell. 2002 Jul 26;110(2):177-89.
19. Mechanism for activation of the growth factor-activated AGC kinases by turn motif phosphorylation. Hauge C, etal., EMBO J. 2007 May 2;26(9):2251-61. Epub 2007 Apr 19.
20. Clofibrate treatment promotes branched-chain amino acid catabolism and decreases the phosphorylation state of mTOR, eIF4E-BP1, and S6K1 in rat liver. Ishiguro H, etal., Life Sci. 2006 Jul 17;79(8):737-43. Epub 2006 Apr 17.
21. Thyroid hormone stimulates protein synthesis in the cardiomyocyte by activating the Akt-mTOR and p70S6K pathways. Kenessey A and Ojamaa K, J Biol Chem. 2006 Jul 28;281(30):20666-72. Epub 2006 May 22.
22. Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance. Khamzina L, etal., Endocrinology. 2005 Mar;146(3):1473-81. Epub 2004 Dec 16.
23. Glucagon represses signaling through the mammalian target of rapamycin in rat liver by activating AMP-activated protein kinase. Kimball SR, etal., J Biol Chem. 2004 Dec 24;279(52):54103-9. Epub 2004 Oct 19.
24. Regulation of p70S6k, GSK-3beta, and calcineurin in rat striated muscle during aging. Kinnard RS, etal., Biogerontology. 2005;6(3):173-84.
25. Cloning of the mitogen-activated S6 kinase from rat liver reveals an enzyme of the second messenger subfamily. Kozma SC, etal., Proc Natl Acad Sci U S A 1990 Oct;87(19):7365-9.
26. Identification and early activation of a Xenopus laevis p70s6k following progesterone-induced meiotic maturation. Lane HA, etal., EMBO J 1992 May;11(5):1743-9.
27. Endotoxin disrupts the leucine-signaling pathway involving phosphorylation of mTOR, 4E-BP1, and S6K1 in skeletal muscle. Lang CH and Frost RA, J Cell Physiol. 2005 Apr;203(1):144-55.
28. Alcohol intoxication impairs phosphorylation of S6K1 and S6 in skeletal muscle independently of ethanol metabolism. Lang CH, etal., Alcohol Clin Exp Res. 2004 Nov;28(11):1758-67.
29. Thermal injury impairs cardiac protein synthesis and is associated with alterations in translation initiation. Lang CH, etal., Am J Physiol Regul Integr Comp Physiol. 2004 Apr;286(4):R740-50. Epub 2003 Dec 24.
30. Antidepressants induce cellular insulin resistance by activation of IRS-1 kinases. Levkovitz Y, etal., Mol Cell Neurosci. 2007 Nov;36(3):305-12. Epub 2007 Jun 29.
31. PHLPP-mediated dephosphorylation of S6K1 inhibits protein translation and cell growth. Liu J, etal., Mol Cell Biol. 2011 Dec;31(24):4917-27. doi: 10.1128/MCB.05799-11. Epub 2011 Oct 10.
32. Amino acids regulate skeletal muscle PHAS-I and p70 S6-kinase phosphorylation independently of insulin. Long W, etal., Am J Physiol Endocrinol Metab. 2000 Aug;279(2):E301-6.
33. Molecular mechanisms of mTOR-mediated translational control. Ma XM and Blenis J, Nat Rev Mol Cell Biol. 2009 May;10(5):307-18. Epub 2009 Apr 2.
34. Rapamycin ameliorates experimental autoimmune myocarditis. Maeda K, etal., Int Heart J. 2005 May;46(3):513-30.
35. Role of insulin, adipocyte hormones, and nutrient-sensing pathways in regulating fuel metabolism and energy homeostasis: a nutritional perspective of diabetes, obesity, and cancer. Marshall S Sci STKE. 2006 Aug 1;2006(346):re7.
36. Oral administration of branched-chain amino acids activates the mTOR signal in cirrhotic rat liver. Matsumura T, etal., Hepatol Res. 2005 Sep;33(1):27-32.
37. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
38. Toxin-induced tail phosphorylation of hepatocellular S6 kinase: evidence for a dual involvement of the AMP-activated protein kinase in S6 kinase regulation. Moller MT, etal., Toxicol Sci. 2004 Dec;82(2):628-37. Epub 2004 Sep 1.
39. Involvement of mitogen-stimulated p70-S6 kinase in the development of sensitization to the methamphetamine-induced rewarding effect in rats. Narita M, etal., Neuroscience. 2005;132(3):553-60.
40. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
41. Inhibition of mammalian translation initiation by volatile anesthetics. Palmer LK, etal., Am J Physiol Endocrinol Metab. 2006 Jun;290(6):E1267-75. Epub 2006 Jan 24.
42. Contraction-mediated mTOR, p70S6k, and ERK1/2 phosphorylation in aged skeletal muscle. Parkington JD, etal., J Appl Physiol. 2004 Jul;97(1):243-8. Epub 2004 Mar 19.
43. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
44. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
45. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
46. Role of mTOR signaling in intestinal cell migration. Rhoads JM, etal., Am J Physiol Gastrointest Liver Physiol. 2006 Sep;291(3):G510-7. Epub 2006 May 18.
47. Uniaxial stretch-induced regulation of mitogen-activated protein kinase, Akt and p70 S6 kinase in the ageing Fischer 344 x Brown Norway rat aorta. Rice KM, etal., Exp Physiol. 2007 Sep;92(5):963-70. Epub 2007 May 25.
48. Hyperinsulinemia: effect on cardiac mass/function, angiotensin II receptor expression, and insulin signaling pathways. Samuelsson AM, etal., Am J Physiol Heart Circ Physiol. 2006 Aug;291(2):H787-96. Epub 2006 Mar 24.
49. Oncopreventive effects of theanine and theobromine on dimethylhydrazine-induced colon cancer model. Shojaei-Zarghani S, etal., Biomed Pharmacother. 2021 Feb;134:111140. doi: 10.1016/j.biopha.2020.111140. Epub 2020 Dec 24.
50. Regulation of the phosphatidylinositol 3-kinase, Akt/protein kinase B, FRAP/mammalian target of rapamycin, and ribosomal S6 kinase 1 signaling pathways by thyroid-stimulating hormone (TSH) and stimulating type TSH receptor antibodies in the thyroid gland. Suh JM, etal., J Biol Chem. 2003 Jun 13;278(24):21960-71. Epub 2003 Mar 30.
51. Signals of oxidant-induced cardiomyocyte hypertrophy: key activation of p70 S6 kinase-1 and phosphoinositide 3-kinase. Tu VC, etal., J Pharmacol Exp Ther 2002 Mar;300(3):1101-10.
52. Regulation of insulin signalling by hyperinsulinaemia: role of IRS-1/2 serine phosphorylation and the mTOR/p70 S6K pathway. Ueno M, etal., Diabetologia. 2005 Mar;48(3):506-18. Epub 2005 Feb 4.
53. Inhibition of mTOR with sirolimus slows disease progression in Han:SPRD rats with autosomal dominant polycystic kidney disease (ADPKD). Wahl PR, etal., Nephrol Dial Transplant. 2006 Mar;21(3):598-604. Epub 2005 Oct 12.
54. Glucocorticoids differentially modulate insulin-mediated protein and glycogen synthetic signaling downstream of protein kinase B in rat myocardium. Wu Y, etal., Endocrinology. 2004 Mar;145(3):1161-6. Epub 2003 Nov 20.
55. Phosphorylation of p70s6 kinase is implicated in androgen-induced levator ani muscle anabolism in castrated rats. Xu T, etal., J Steroid Biochem Mol Biol. 2004 Dec;92(5):447-54. Epub 2004 Dec 21.
56. S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2. Zhang J, etal., J Biol Chem. 2008 Dec 19;283(51):35375-82. doi: 10.1074/jbc.M806480200. Epub 2008 Oct 24.
Additional References at PubMed
PMID:11493700   PMID:12140361   PMID:12477932   PMID:12663469   PMID:12971962   PMID:14660591   PMID:14673156   PMID:14993219   PMID:15010853   PMID:15249583   PMID:15589845   PMID:15677443  
PMID:15774499   PMID:16087221   PMID:16763566   PMID:16895915   PMID:17220300   PMID:17556672   PMID:17588536   PMID:17936702   PMID:18097751   PMID:18187610   PMID:18234235   PMID:18279656  
PMID:18347658   PMID:18423201   PMID:18618016   PMID:19041762   PMID:19085255   PMID:19622787   PMID:19801385   PMID:20029971   PMID:20368999   PMID:20399760   PMID:20664065   PMID:20678995  
PMID:20967511   PMID:21228503   PMID:21404070   PMID:21472380   PMID:21602475   PMID:21720156   PMID:22684415   PMID:22705322   PMID:22797923   PMID:22927400   PMID:23707523   PMID:23994018  
PMID:24067463   PMID:24349514   PMID:24801387   PMID:24990923   PMID:25040634   PMID:25200811   PMID:25304210   PMID:25358492   PMID:25568312   PMID:25903132   PMID:25918363   PMID:26706460  
PMID:28041982   PMID:28178239   PMID:28898133   PMID:29750193   PMID:33179842   PMID:34655015   PMID:34874016   PMID:36527650   PMID:38570425   PMID:39236462  


Genomics

Comparative Map Data
Rps6kb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81071,817,794 - 71,865,211 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1071,815,614 - 71,865,238 (-)EnsemblGRCr8
mRatBN7.21071,323,777 - 71,367,908 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1071,323,777 - 71,367,908 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1075,946,721 - 75,987,672 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01075,451,529 - 75,492,547 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01070,916,142 - 70,957,095 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01073,824,200 - 73,865,503 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1073,824,202 - 73,865,364 (-)Ensemblrn6Rnor6.0
Rnor_5.01076,234,192 - 76,278,394 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41076,657,024 - 76,698,088 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1070,248,523 - 70,289,589 (-)NCBICelera
RGSC_v3.11076,671,395 - 76,712,458 (-)NCBI
Cytogenetic Map10q26NCBI
RPS6KB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381759,893,121 - 59,950,574 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1759,893,046 - 59,950,574 (+)Ensemblhg38GRCh38
GRCh371757,970,482 - 58,027,935 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361755,325,225 - 55,382,569 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341755,325,224 - 55,382,566NCBI
Celera1754,433,949 - 54,491,301 (+)NCBICelera
Cytogenetic Map17q23.1NCBI
HuRef1753,342,941 - 53,400,248 (+)NCBIHuRef
CHM1_11758,034,428 - 58,091,804 (+)NCBICHM1_1
T2T-CHM13v2.01760,761,869 - 60,819,318 (+)NCBIT2T-CHM13v2.0
Rps6kb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391186,389,695 - 86,435,711 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1186,389,697 - 86,435,631 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381186,498,869 - 86,544,885 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1186,498,871 - 86,544,805 (-)Ensemblmm10GRCm38
MGSCv371186,312,511 - 86,358,309 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361186,330,178 - 86,360,969 (-)NCBIMGSCv36mm8
Celera1196,115,093 - 96,160,675 (-)NCBICelera
Cytogenetic Map11CNCBI
cM Map1151.82NCBI
Rps6kb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554513,181,085 - 3,225,610 (-)Ensembl
ChiLan1.0NW_0049554513,181,085 - 3,225,610 (-)NCBIChiLan1.0ChiLan1.0
RPS6KB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21976,055,147 - 76,111,993 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11780,866,830 - 80,922,483 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01753,958,807 - 54,014,752 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11758,798,930 - 58,856,480 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1758,799,069 - 58,853,653 (+)EnsemblpanPan2panpan1.1
RPS6KB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1934,387,084 - 34,590,603 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl934,387,091 - 34,425,292 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha933,618,891 - 33,820,779 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0935,197,993 - 35,401,137 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl935,198,048 - 35,253,131 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1933,981,681 - 34,184,055 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0934,266,735 - 34,469,058 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0934,353,112 - 34,555,827 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rps6kb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560233,582,174 - 33,634,004 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364903,441,055 - 3,492,917 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364903,441,046 - 3,492,917 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RPS6KB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1236,111,653 - 36,160,376 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11236,111,584 - 36,159,287 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21237,386,770 - 37,434,407 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RPS6KB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11633,498,098 - 33,556,553 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1633,497,392 - 33,556,453 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660774,283,812 - 4,342,844 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rps6kb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248711,667,291 - 1,702,783 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248711,667,292 - 1,705,550 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Rps6kb1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1984,229,507 - 84,272,843 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rps6kb1
409 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:147
Count of miRNA genes:119
Interacting mature miRNAs:128
Transcripts:ENSRNOT00000005226
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
631565Hcuc4Hepatic copper content QTL 44.15liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)106743947373950209Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
8657410Bp374Blood pressure QTL 374heart left ventricle size trait (VT:0002753)heart left ventricle end-diastolic diameter (CMO:0000982)1067476608107713808Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105216243375582749Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063719161107713808Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)105686844076129113Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1058073360103073360Rat
12903252Cm113Cardiac mass QTL 1130.047heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1064939013107713808Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
12903269Am15Aortic mass QTL 150.042aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
12903266Cm114Cardiac mass QTL 1140.02heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)1066817119107713808Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
2313103Bss80Bone structure and strength QTL 8020.0001tibia strength trait (VT:1000284)tibia midshaft endosteal cross-sectional area (CMO:0001716)1062556066107556066Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
12880372Am12Aortic mass QTL 120.003aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)1066817119107713808Rat
2313105Bss79Bone structure and strength QTL 791.80.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)1062556066107556066Rat
12880375Kidm66Kidney mass QTL 660.009kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
1357344Bp249Blood pressure QTL 2490.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)106724133498502431Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
12880370Cm105Cardiac mass QTL 1050.008heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
12880371Cm106Cardiac mass QTL 1060.007heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)1066817119107713808Rat
2306970Anxrr22Anxiety related response QTL 225.95fear/anxiety-related behavior trait (VT:1000241)number of periods of voluntary immobility (CMO:0001045)106184349698710773Rat
11565453Kidm58Kidney mass QTL 580.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1066817119107713808Rat
7387312Bw125Body weight QTL 12530.0047retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight (CMO:0000356)1065390777107713808Rat
2317029Aia19Adjuvant induced arthritis QTL 192.98joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)106747660873695498Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
2317039Aia6Adjuvant induced arthritis QTL 64.31joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)106747660873695498Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
2298481Eau9Experimental allergic uveoretinitis QTL 90.0169uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)106413959783061459Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
61396Bp9Blood pressure QTL 94.80.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1068920187107713808Rat
1358915Stresp7Stress response QTL 73.52blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)1065307813107713808Rat
70363Bp71Blood pressure QTL 710.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1061843496106843496Rat
61402Niddm3Non-insulin dependent diabetes mellitus QTL 34.58blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)106184363383061236Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
6893366Bw106Body weight QTL 1060.30.47body mass (VT:0001259)body weight (CMO:0000012)1070698731107713808Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
1354608Cm33Cardiac mass QTL 332.8heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)105530797293608131Rat
1558643Cm44Cardiac mass QTL 444.80.0000368heart mass (VT:0007028)heart wet weight (CMO:0000069)1061843496100198886Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
1581559Eae18Experimental allergic encephalomyelitis QTL 180.00002nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1066108888107555881Rat
6893336Cm75Cardiac mass QTL 750.10.87heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1061843496100198886Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
634354Rends3Renal damage susceptibility QTL 30.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)1061997479106997479Rat
2301405Cm69Cardiac mass QTL 690.031heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)1066817119107713808Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
D10Chm208  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21071,354,565 - 71,354,799 (+)MAPPERmRatBN7.2
Rnor_6.01073,852,062 - 73,852,295NCBIRnor6.0
Rnor_5.01076,247,284 - 76,247,517UniSTSRnor5.0
RGSC_v3.41076,684,790 - 76,685,023UniSTSRGSC3.4
Celera1070,276,286 - 70,276,525UniSTS
Cytogenetic Map10q26UniSTS
D10Chm209  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21071,336,502 - 71,336,709 (+)MAPPERmRatBN7.2
Rnor_6.01073,833,727 - 73,833,933NCBIRnor6.0
Rnor_5.01076,265,646 - 76,265,852UniSTSRnor5.0
RGSC_v3.41076,666,730 - 76,666,936UniSTSRGSC3.4
Celera1070,258,229 - 70,258,435UniSTS
Cytogenetic Map10q26UniSTS
RH142624  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21071,363,836 - 71,363,944 (+)MAPPERmRatBN7.2
Rnor_6.01073,861,335 - 73,861,442NCBIRnor6.0
Rnor_5.01076,238,137 - 76,238,244UniSTSRnor5.0
RGSC_v3.41076,694,060 - 76,694,167UniSTSRGSC3.4
Celera1070,285,561 - 70,285,668UniSTS
Cytogenetic Map10q26UniSTS
AU046947  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21071,336,512 - 71,336,755 (+)MAPPERmRatBN7.2
Rnor_6.01073,833,737 - 73,833,979NCBIRnor6.0
Rnor_5.01076,265,600 - 76,265,842UniSTSRnor5.0
RGSC_v3.41076,666,740 - 76,666,982UniSTSRGSC3.4
Celera1070,258,239 - 70,258,481UniSTS
Cytogenetic Map10q26UniSTS
RH127558  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21071,331,490 - 71,331,680 (+)MAPPERmRatBN7.2
Rnor_6.01073,828,894 - 73,829,083NCBIRnor6.0
Rnor_5.01076,270,496 - 76,270,685UniSTSRnor5.0
RGSC_v3.41076,661,718 - 76,661,907UniSTSRGSC3.4
Celera1070,253,217 - 70,253,406UniSTS
Cytogenetic Map10q26UniSTS
AU049777  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01076,236,937 - 76,237,232UniSTSRnor5.0
Cytogenetic Map10q26UniSTS
RH136097  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21071,327,337 - 71,327,503 (+)MAPPERmRatBN7.2
Rnor_6.01073,824,740 - 73,824,905NCBIRnor6.0
Rnor_5.01076,274,674 - 76,274,839UniSTSRnor5.0
RGSC_v3.41076,657,564 - 76,657,729UniSTSRGSC3.4
Celera1070,249,063 - 70,249,228UniSTS
Cytogenetic Map10q26UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
17 13 75 206 91 90 59 143 59 6 447 261 22 184 102 114 31 34 34

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006247111 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008768120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008768121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063269985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005489956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010055269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_010055270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC114846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC089789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M58340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000005226   ⟹   ENSRNOP00000005226
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1071,838,582 - 71,865,238 (-)Ensembl
mRatBN7.2 Ensembl1071,341,234 - 71,367,908 (-)Ensembl
Rnor_6.0 Ensembl1073,824,202 - 73,865,364 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118136   ⟹   ENSRNOP00000087269
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1071,824,151 - 71,865,238 (-)Ensembl
mRatBN7.2 Ensembl1071,323,777 - 71,367,904 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000118202   ⟹   ENSRNOP00000078345
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1071,815,614 - 71,865,211 (-)Ensembl
mRatBN7.2 Ensembl1071,323,777 - 71,367,904 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000122089   ⟹   ENSRNOP00000111651
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1071,824,151 - 71,865,211 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000157804   ⟹   ENSRNOP00000102550
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1071,824,151 - 71,865,211 (-)Ensembl
RefSeq Acc Id: NM_031985   ⟹   NP_114191
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81071,824,149 - 71,865,211 (-)NCBI
mRatBN7.21071,326,798 - 71,367,865 (-)NCBI
Rnor_6.01073,824,200 - 73,865,364 (-)NCBI
Rnor_5.01076,234,192 - 76,278,394 (+)NCBI
RGSC_v3.41076,657,024 - 76,698,088 (-)RGD
Celera1070,248,523 - 70,289,589 (-)RGD
Sequence:
RefSeq Acc Id: XM_006247111   ⟹   XP_006247173
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81071,824,149 - 71,865,190 (-)NCBI
mRatBN7.21071,327,600 - 71,367,908 (-)NCBI
Rnor_6.01073,825,028 - 73,865,496 (-)NCBI
Rnor_5.01076,234,192 - 76,278,394 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063269979   ⟹   XP_063126049
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81071,825,095 - 71,865,190 (-)NCBI
RefSeq Acc Id: XM_063269980   ⟹   XP_063126050
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81071,825,095 - 71,865,190 (-)NCBI
RefSeq Acc Id: XM_063269981   ⟹   XP_063126051
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81071,825,095 - 71,864,553 (-)NCBI
RefSeq Acc Id: XM_063269982   ⟹   XP_063126052
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81071,817,794 - 71,865,190 (-)NCBI
RefSeq Acc Id: XM_063269983   ⟹   XP_063126053
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81071,825,095 - 71,839,460 (-)NCBI
RefSeq Acc Id: XM_063269984   ⟹   XP_063126054
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81071,838,673 - 71,865,190 (-)NCBI
RefSeq Acc Id: XM_063269985   ⟹   XP_063126055
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81071,837,668 - 71,865,190 (-)NCBI
RefSeq Acc Id: XR_005489956
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81071,833,241 - 71,865,190 (-)NCBI
mRatBN7.21071,335,889 - 71,367,908 (-)NCBI
RefSeq Acc Id: XR_010055269
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81071,835,303 - 71,865,190 (-)NCBI
RefSeq Acc Id: XR_010055270
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81071,835,304 - 71,865,190 (-)NCBI
RefSeq Acc Id: NP_114191   ⟸   NM_031985
- UniProtKB: P67999 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006247173   ⟸   XM_006247111
- Peptide Label: isoform X5
- UniProtKB: P67999 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005226   ⟸   ENSRNOT00000005226
Ensembl Acc Id: ENSRNOP00000078345   ⟸   ENSRNOT00000118202
Ensembl Acc Id: ENSRNOP00000087269   ⟸   ENSRNOT00000118136
RefSeq Acc Id: XP_063126052   ⟸   XM_063269982
- Peptide Label: isoform X4
- UniProtKB: P67999 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063126050   ⟸   XM_063269980
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063126049   ⟸   XM_063269979
- Peptide Label: isoform X1
- UniProtKB: P67999 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063126051   ⟸   XM_063269981
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063126053   ⟸   XM_063269983
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063126055   ⟸   XM_063269985
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063126054   ⟸   XM_063269984
- Peptide Label: isoform X7
Ensembl Acc Id: ENSRNOP00000102550   ⟸   ENSRNOT00000157804
Ensembl Acc Id: ENSRNOP00000111651   ⟸   ENSRNOT00000122089
Protein Domains
AGC-kinase C-terminal   Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P67999-F1-model_v2 AlphaFold P67999 1-525 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697564
Promoter ID:EPDNEW_R8088
Type:multiple initiation site
Name:Rps6kb1_1
Description:ribosomal protein S6 kinase B1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01073,865,407 - 73,865,467EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620683 AgrOrtholog
BioCyc Gene G2FUF-23803 BioCyc
Ensembl Genes ENSRNOG00000003919 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000118202 ENTREZGENE
  ENSRNOT00000118202.1 UniProtKB/Swiss-Prot
  ENSRNOT00000122089 ENTREZGENE
  ENSRNOT00000157804 ENTREZGENE
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7365967 IMAGE-MGC_LOAD
InterPro AGC-kinase_C UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Pkinase_C UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ribosomal_S6_kinase UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:83840 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108647 IMAGE-MGC_LOAD
NCBI Gene 83840 ENTREZGENE
PANTHER RIBOSOMAL PROTEIN S6 KINASE UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
  Pkinase_C UniProtKB/Swiss-Prot
PhenoGen Rps6kb1 PhenoGen
PIRSF Ribsml_S6_kin_1 UniProtKB/Swiss-Prot
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000003919 RatGTEx
SMART S_TK_X UniProtKB/Swiss-Prot
  S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt A0A8I6A855_RAT UniProtKB/TrEMBL
  A0A8L2Q2Q3_RAT UniProtKB/TrEMBL
  A0ABK0LM96_RAT UniProtKB/TrEMBL
  A6HHQ9_RAT UniProtKB/TrEMBL
  A6HHR0_RAT UniProtKB/TrEMBL
  KS6B1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P21425 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-11 Rps6kb1  ribosomal protein S6 kinase B1  Rps6kb1  ribosomal protein S6 kinase, polypeptide 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-04-27 Rps6kb1  ribosomal protein S6 kinase, polypeptide 1  Rps6kb1  ribosomal protein S6 kinase, 70kDa, polypeptide 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Rps6kb1  ribosomal protein S6 kinase, 70kDa, polypeptide 1  Rps6kb1  ribosomal protein S6 kinase, polypeptide 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Rps6kb1  ribosomal protein S6 kinase, polypeptide 1    S6 kinase  Name updated 1299863 APPROVED
2002-08-07 Rps6kb1  S6 kinase      Symbol and Name status set to provisional 70820 PROVISIONAL