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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620683
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rps6kb1
Name: ribosomal protein S6 kinase B1
Acc ID: CHEBI:41774
Term: tamoxifen
Definition: A stilbenoid that has formula 371.51460.
Chemical ID: MESH:D013629
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rps6kb1decreases phosphorylationISORPS6KB1 (Homo sapiens)6480464CTDTamoxifen results in decreased phosphorylation of RPS6KB1 proteinPMID:19931998
Rps6kb1increases activityISORPS6KB1 (Homo sapiens)6480464CTD[Tamoxifen results in increased activity of AKT1 protein] which results in increased activity of RPS6KB1 proteinPMID:20372086
Rps6kb1multiple interactionsISORPS6KB1 (Homo sapiens)6480464CTD[Tamoxifen results in decreased activity of MTOR protein] which results in decreased phosphorylation of RPS6KB1 proteinPMID:19931998
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