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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620683
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rps6kb1
Name: ribosomal protein S6 kinase B1
Acc ID: CHEBI:68478
Term: everolimus
Definition: A macrocyclic lactone that is rapamycin in which the hydroxy group attached to the cyclohexyl moiety has been converted into the corresponding 2-hydroxyethyl ether. It is an immunosuppressant and antineoplastic agent.
Chemical ID: MESH:C107135
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rps6kb1multiple interactionsEXP 6480464CTDEverolimus inhibits the reaction [rhodioloside inhibits the reaction [[cobaltous chloride co-treated with NGF protein] results in decreased phosphorylation of RPS6KB1 protein]]PMID:24989011
Rps6kb1multiple interactionsISORPS6KB1 (Homo sapiens)6480464CTDEverolimus inhibits the reaction [Estradiol results in increased phosphorylation of RPS6KB1 protein]; Everolimus inhibits the reaction [TNF protein results in increased phosphorylation of RPS6KB1 protein]PMID:16033851 PMID:19567381
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