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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620683
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rps6kb1
Name: ribosomal protein S6 kinase B1
Acc ID: CHEBI:29866
Term: arsenite(3-)
Definition: An arsenite ion resulting from the removal of all three protons from the hydroxy groups of arsenous acid.
Chemical ID: MESH:C015001
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rps6kb1increases phosphorylationEXP 6480464CTDarsenite results in increased phosphorylation of RPS6KB1 proteinPMID:17038550 PMID:20377179
Rps6kb1multiple interactionsEXP 6480464CTDQuercetin inhibits the reaction [arsenite results in increased phosphorylation of RPS6KB1 protein]PMID:20377179
Rps6kb1decreases phosphorylationISORps6kb1 (Mus musculus)6480464CTDarsenite results in decreased phosphorylation of RPS6KB1 proteinPMID:20589738
Rps6kb1increases phosphorylationISORPS6KB1 (Homo sapiens)6480464CTDarsenite results in increased phosphorylation of RPS6KB1 proteinPMID:22215663
Rps6kb1increases phosphorylationISORps6kb1 (Mus musculus)6480464CTDarsenite results in increased phosphorylation of RPS6KB1 proteinPMID:22215663 PMID:23396362
Rps6kb1multiple interactionsISORPS6KB1 (Homo sapiens)6480464CTD2-(methylamino)isobutyric acid inhibits the reaction [arsenite results in increased phosphorylation of RPS6KB1 protein]; [sodium arsenite results in increased abundance of arsenite] which results in increased phosphorylation of RPS6KB1 protein; Sirolimus inhibits the reaction [arsenite results in increased phosphorylation of RPS6KB1 protein]; SLC38A2 mutant form inhibits the reaction [arsenite results in increased phosphorylation of RPS6KB1 protein]PMID:22215663 PMID:31781319
Rps6kb1multiple interactionsISORps6kb1 (Mus musculus)6480464CTD1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]; Acetylcysteine inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]; arsenite results in increased phosphorylation of and results in increased activity of RPS6KB1 protein; CAT protein inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]; Egtazic Acid inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]; NFKB1 protein affects the reaction [arsenite results in increased phosphorylation of RPS6KB1 protein]; pyrazolanthrone inhibits the reaction [arsenite results in decreased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]; Sirolimus inhibits the reaction [arsenite results in increased phosphorylation of RPS6KB1 protein]; Wortmannin inhibits the reaction [arsenite affects the activity of RPS6KB1 protein]PMID:14516795 PMID:20589738 PMID:22215663 PMID:23396362
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