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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620683
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rps6kb1
Name: ribosomal protein S6 kinase B1
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rps6kb1multiple interactionsEXP 6480464CTD1-Butanol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]; [Rotenone results in increased abundance of Hydrogen Peroxide] inhibits the reaction [MTOR protein results in increased phosphorylation of RPS6KB1 protein]; CAT protein inhibits the reaction [[Rotenone results in increased abundance of Hydrogen Peroxide] inhibits the reaction [MTOR protein results in increased phosphorylation of RPS6KB1 protein]]; Hydrogen Peroxide results in increased phosphorylation of and results in increased activity of RPS6KB1 protein; RPS6KB1 protein inhibits the reaction [Rotenone results in increased abundance of Hydrogen Peroxide]PMID:15705590 PMID:25304210
Rps6kb1decreases phosphorylationISORPS6KB1 (Homo sapiens)6480464CTDHydrogen Peroxide results in decreased phosphorylation of RPS6KB1 proteinPMID:19451193
Rps6kb1increases expressionISORPS6KB1 (Homo sapiens)6480464CTDHydrogen Peroxide results in increased expression of RPS6KB1 proteinPMID:18603805
Rps6kb1increases phosphorylationISORPS6KB1 (Homo sapiens)6480464CTDHydrogen Peroxide results in increased phosphorylation of RPS6KB1 proteinPMID:36162953
Rps6kb1multiple interactionsISORPS6KB1 (Homo sapiens)6480464CTDepigallocatechin gallate promotes the reaction [Warfarin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of RPS6KB1 protein]]; Warfarin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of RPS6KB1 protein]PMID:36162953
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