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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620683
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rps6kb1
Name: ribosomal protein S6 kinase B1
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rps6kb1decreases expressionEXP 6480464CTDresveratrol results in decreased expression of RPS6KB1 protein modified formPMID:25394677
Rps6kb1decreases phosphorylationEXP 6480464CTDresveratrol results in decreased phosphorylation of RPS6KB1 proteinPMID:18562309 PMID:24304514
Rps6kb1multiple interactionsEXP 6480464CTD[Sirolimus co-treated with Resveratrol] results in decreased phosphorylation of RPS6KB1 protein; Resveratrol inhibits the reaction [AGT protein modified form results in increased expression of RPS6KB1 protein modified form]; Resveratrol inhibits the reaction [AGT protein modified form results in increased phosphorylation of RPS6KB1 protein]; Resveratrol inhibits the reaction [IGF1 protein results in increased expression of RPS6KB1 protein modified form]; Resveratrol inhibits the reaction [Phenylephrine results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]; Resveratrol inhibits the reaction [TSC2 protein results in decreased phosphorylation of RPS6KB1 protein]; Sirolimus inhibits the reaction [Resveratrol inhibits the reaction [TSC2 protein results in decreased phosphorylation of RPS6KB1 protein]]PMID:12237323 PMID:18562309 PMID:24304514 PMID:25394677
Rps6kb1decreases activityISORPS6KB1 (Homo sapiens)6480464CTDresveratrol results in decreased activity of RPS6KB1 proteinPMID:15297429 PMID:21544240 PMID:26189302
Rps6kb1decreases expressionISORPS6KB1 (Homo sapiens)6480464CTDresveratrol results in decreased expression of RPS6KB1 protein; resveratrol results in decreased expression of RPS6KB1 protein modified formPMID:17534123 PMID:21224254 PMID:23314035 PMID:25394677
Rps6kb1decreases expressionISORps6kb1 (Mus musculus)6480464CTDresveratrol results in decreased expression of RPS6KB1 protein modified formPMID:21224254
Rps6kb1decreases phosphorylationISORPS6KB1 (Homo sapiens)6480464CTDresveratrol results in decreased phosphorylation of RPS6KB1 proteinPMID:16979140 PMID:21168265 PMID:23248098 PMID:23292070 PMID:24331535
Rps6kb1decreases phosphorylationISORps6kb1 (Mus musculus)6480464CTDresveratrol results in decreased phosphorylation of RPS6KB1 proteinPMID:24304514 PMID:26223300
Rps6kb1increases phosphorylationISORPS6KB1 (Homo sapiens)6480464CTDresveratrol results in increased phosphorylation of RPS6KB1 proteinPMID:23680031
Rps6kb1multiple interactionsISORPS6KB1 (Homo sapiens)6480464CTD3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [Resveratrol results in decreased phosphorylation of RPS6KB1 protein]; [Resveratrol co-treated with Sirolimus] results in increased phosphorylation of RPS6KB1 protein; [Resveratrol results in decreased activity of MTOR protein] which results in decreased phosphorylation of RPS6KB1 protein; [Resveratrol results in decreased activity of RPS6KB1 protein] which results in decreased abundance of Superoxides; [Resveratrol results in decreased activity of RPS6KB1 protein] which results in decreased phosphorylation of RPS6 protein; [Resveratrol results in decreased activity of RPS6KB1 protein] which results in increased abundance of Nitric Oxide; [Resveratrol results in increased abundance of Calcium] which results in decreased expression of RPS6KB1 protein modified form; dorsomorphin inhibits the reaction [[Resveratrol results in increased abundance of Calcium] which results in decreased expression of RPS6KB1 protein modified form]; Resveratrol inhibits the reaction [IGF1 protein results in increased phosphorylation of RPS6KB1 protein]; Resveratrol inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of RPS6KB1 protein]; Resveratrol promotes the reaction [Erlotinib Hydrochloride results in decreased phosphorylation of RPS6KB1 protein]; SIRT1 mutant form inhibits the reaction [Resveratrol results in decreased phosphorylation of RPS6KB1 protein]; TSC2 mutant form inhibits the reaction [Resveratrol results in decreased phosphorylation of RPS6KB1 protein]PMID:15297429 PMID:17919812 PMID:21544240 PMID:22574221 PMID:23248098 PMID:23292070 PMID:23680031 PMID:24304514 PMID:25895606
Rps6kb1multiple interactionsISORps6kb1 (Mus musculus)6480464CTD[[resveratrol results in increased activity of SIRT1 protein] which results in decreased activity of MTOR protein] which results in decreased phosphorylation of RPS6KB1 protein; [Sirolimus co-treated with resveratrol] inhibits the reaction [TSC2 gene mutant form results in increased phosphorylation of RPS6KB1 protein]; resveratrol inhibits the reaction [AGT protein modified form results in increased expression of RPS6KB1 protein modified form]; resveratrol inhibits the reaction [TNF protein results in decreased phosphorylation of RPS6KB1 protein]; Sirolimus promotes the reaction [resveratrol results in decreased phosphorylation of RPS6KB1 protein]PMID:21321189 PMID:24304514 PMID:24534773 PMID:25394677
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